id sid tid token lemma pos vx021c20z3n 1 1 the the DET vx021c20z3n 1 2 hematopoietic hematopoietic ADJ vx021c20z3n 1 3 niche niche NOUN vx021c20z3n 1 4 is be AUX vx021c20z3n 1 5 crucial crucial ADJ vx021c20z3n 1 6 for for ADP vx021c20z3n 1 7 maintenance maintenance NOUN vx021c20z3n 1 8 of of ADP vx021c20z3n 1 9 homeostasis homeostasis NOUN vx021c20z3n 1 10 and and CCONJ vx021c20z3n 1 11 the the DET vx021c20z3n 1 12 blood blood NOUN vx021c20z3n 1 13 stem stem NOUN vx021c20z3n 1 14 cell cell NOUN vx021c20z3n 1 15 population population NOUN vx021c20z3n 1 16 . . PUNCT vx021c20z3n 2 1 while while SCONJ vx021c20z3n 2 2 mirnas mirna NOUN vx021c20z3n 2 3 have have AUX vx021c20z3n 2 4 been be AUX vx021c20z3n 2 5 shown show VERB vx021c20z3n 2 6 to to PART vx021c20z3n 2 7 be be AUX vx021c20z3n 2 8 vital vital ADJ vx021c20z3n 2 9 for for ADP vx021c20z3n 2 10 normal normal ADJ vx021c20z3n 2 11 blood blood NOUN vx021c20z3n 2 12 development development NOUN vx021c20z3n 2 13 and and CCONJ vx021c20z3n 2 14 play play VERB vx021c20z3n 2 15 a a DET vx021c20z3n 2 16 role role NOUN vx021c20z3n 2 17 in in ADP vx021c20z3n 2 18 cancers cancer NOUN vx021c20z3n 2 19 of of ADP vx021c20z3n 2 20 the the DET vx021c20z3n 2 21 blood blood NOUN vx021c20z3n 2 22 , , PUNCT vx021c20z3n 2 23 relatively relatively ADV vx021c20z3n 2 24 little little ADJ vx021c20z3n 2 25 is be AUX vx021c20z3n 2 26 known know VERB vx021c20z3n 2 27 about about ADP vx021c20z3n 2 28 mirnas mirna NOUN vx021c20z3n 2 29 in in ADP vx021c20z3n 2 30 the the DET vx021c20z3n 2 31 blood blood NOUN vx021c20z3n 2 32 stem stem NOUN vx021c20z3n 2 33 cell cell NOUN vx021c20z3n 2 34 niche niche NOUN vx021c20z3n 2 35 in in ADP vx021c20z3n 2 36 regards regard NOUN vx021c20z3n 2 37 to to ADP vx021c20z3n 2 38 what what PRON vx021c20z3n 2 39 mirnas mirna NOUN vx021c20z3n 2 40 are be AUX vx021c20z3n 2 41 important important ADJ vx021c20z3n 2 42 , , PUNCT vx021c20z3n 2 43 what what PRON vx021c20z3n 2 44 their their PRON vx021c20z3n 2 45 targets target NOUN vx021c20z3n 2 46 are be AUX vx021c20z3n 2 47 and and CCONJ vx021c20z3n 2 48 what what PRON vx021c20z3n 2 49 pathways pathway NOUN vx021c20z3n 2 50 they they PRON vx021c20z3n 2 51 operate operate VERB vx021c20z3n 2 52 in in ADP vx021c20z3n 2 53 . . PUNCT vx021c20z3n 3 1 the the DET vx021c20z3n 3 2 work work NOUN vx021c20z3n 3 3 of of ADP vx021c20z3n 3 4 this this DET vx021c20z3n 3 5 dissertation dissertation NOUN vx021c20z3n 3 6 advantageously advantageously ADV vx021c20z3n 3 7 employs employ VERB vx021c20z3n 3 8 drosophila drosophila NOUN vx021c20z3n 3 9 as as ADP vx021c20z3n 3 10 a a DET vx021c20z3n 3 11 model model NOUN vx021c20z3n 3 12 to to PART vx021c20z3n 3 13 better well ADV vx021c20z3n 3 14 understand understand VERB vx021c20z3n 3 15 the the DET vx021c20z3n 3 16 role role NOUN vx021c20z3n 3 17 mirnas mirna NOUN vx021c20z3n 3 18 play play VERB vx021c20z3n 3 19 in in ADP vx021c20z3n 3 20 the the DET vx021c20z3n 3 21 intricate intricate ADJ vx021c20z3n 3 22 relationship relationship NOUN vx021c20z3n 3 23 between between ADP vx021c20z3n 3 24 hematopoietic hematopoietic ADJ vx021c20z3n 3 25 progenitors progenitor NOUN vx021c20z3n 3 26 and and CCONJ vx021c20z3n 3 27 their their PRON vx021c20z3n 3 28 supportive supportive ADJ vx021c20z3n 3 29 niche niche NOUN vx021c20z3n 3 30 , , PUNCT vx021c20z3n 3 31 and and CCONJ vx021c20z3n 3 32 how how SCONJ vx021c20z3n 3 33 aberrant aberrant ADJ vx021c20z3n 3 34 signaling signal VERB vx021c20z3n 3 35 causes cause VERB vx021c20z3n 3 36 this this DET vx021c20z3n 3 37 system system NOUN vx021c20z3n 3 38 to to PART vx021c20z3n 3 39 result result VERB vx021c20z3n 3 40 in in ADP vx021c20z3n 3 41 hematopoietic hematopoietic ADJ vx021c20z3n 3 42 malignancy malignancy NOUN vx021c20z3n 3 43 . . PUNCT vx021c20z3n 4 1 i i PRON vx021c20z3n 4 2 demonstrate demonstrate VERB vx021c20z3n 4 3 that that SCONJ vx021c20z3n 4 4 bantam bantam NOUN vx021c20z3n 4 5 mirna mirna PROPN vx021c20z3n 4 6 is be AUX vx021c20z3n 4 7 an an DET vx021c20z3n 4 8 essential essential ADJ vx021c20z3n 4 9 positive positive ADJ vx021c20z3n 4 10 regulator regulator NOUN vx021c20z3n 4 11 of of ADP vx021c20z3n 4 12 growth growth NOUN vx021c20z3n 4 13 endogenously endogenously ADV vx021c20z3n 4 14 active active ADJ vx021c20z3n 4 15 in in ADP vx021c20z3n 4 16 the the DET vx021c20z3n 4 17 blood blood NOUN vx021c20z3n 4 18 stem stem NOUN vx021c20z3n 4 19 cell cell NOUN vx021c20z3n 4 20 - - PUNCT vx021c20z3n 4 21 like like ADJ vx021c20z3n 4 22 niche niche NOUN vx021c20z3n 4 23 , , PUNCT vx021c20z3n 4 24 whose whose DET vx021c20z3n 4 25 loss loss NOUN vx021c20z3n 4 26 leads lead VERB vx021c20z3n 4 27 to to ADP vx021c20z3n 4 28 severe severe ADJ vx021c20z3n 4 29 niche niche NOUN vx021c20z3n 4 30 reduction reduction NOUN vx021c20z3n 4 31 . . PUNCT vx021c20z3n 5 1 bantam bantam NOUN vx021c20z3n 5 2 facilitates facilitate VERB vx021c20z3n 5 3 growth growth NOUN vx021c20z3n 5 4 through through ADP vx021c20z3n 5 5 targeting target VERB vx021c20z3n 5 6 of of ADP vx021c20z3n 5 7 a a DET vx021c20z3n 5 8 negative negative ADJ vx021c20z3n 5 9 regulator regulator NOUN vx021c20z3n 5 10 of of ADP vx021c20z3n 5 11 cell cell NOUN vx021c20z3n 5 12 proliferation proliferation NOUN vx021c20z3n 5 13 , , PUNCT vx021c20z3n 5 14 which which PRON vx021c20z3n 5 15 i i PRON vx021c20z3n 5 16 have have AUX vx021c20z3n 5 17 determined determine VERB vx021c20z3n 5 18 to to PART vx021c20z3n 5 19 be be AUX vx021c20z3n 5 20 suppressor suppressor NOUN vx021c20z3n 5 21 of of ADP vx021c20z3n 5 22 cytokine cytokine NOUN vx021c20z3n 5 23 signaling signal VERB vx021c20z3n 5 24 at at ADP vx021c20z3n 5 25 36e 36e NUM vx021c20z3n 5 26 ( ( PUNCT vx021c20z3n 5 27 socs36e socs36e PROPN vx021c20z3n 5 28 ) ) PUNCT vx021c20z3n 5 29 . . PUNCT vx021c20z3n 6 1 additionally additionally ADV vx021c20z3n 6 2 i i PRON vx021c20z3n 6 3 show show VERB vx021c20z3n 6 4 that that SCONJ vx021c20z3n 6 5 the the DET vx021c20z3n 6 6 evolutionarily evolutionarily ADV vx021c20z3n 6 7 conserved conserved ADJ vx021c20z3n 6 8 epidermal epidermal ADJ vx021c20z3n 6 9 growth growth NOUN vx021c20z3n 6 10 factor factor NOUN vx021c20z3n 6 11 receptor receptor NOUN vx021c20z3n 6 12 ( ( PUNCT vx021c20z3n 6 13 egfr egfr PROPN vx021c20z3n 6 14 ) ) PUNCT vx021c20z3n 6 15 , , PUNCT vx021c20z3n 6 16 whose whose DET vx021c20z3n 6 17 aberrant aberrant ADJ vx021c20z3n 6 18 activation activation NOUN vx021c20z3n 6 19 has have AUX vx021c20z3n 6 20 been be AUX vx021c20z3n 6 21 previously previously ADV vx021c20z3n 6 22 correlated correlate VERB vx021c20z3n 6 23 with with ADP vx021c20z3n 6 24 human human ADJ vx021c20z3n 6 25 cancers cancer NOUN vx021c20z3n 6 26 , , PUNCT vx021c20z3n 6 27 is be AUX vx021c20z3n 6 28 vital vital ADJ vx021c20z3n 6 29 for for ADP vx021c20z3n 6 30 niche niche NOUN vx021c20z3n 6 31 maintenance maintenance NOUN vx021c20z3n 6 32 . . PUNCT vx021c20z3n 7 1 under under ADP vx021c20z3n 7 2 conditions condition NOUN vx021c20z3n 7 3 of of ADP vx021c20z3n 7 4 elevated elevated ADJ vx021c20z3n 7 5 egfr egfr PROPN vx021c20z3n 7 6 , , PUNCT vx021c20z3n 7 7 socs36e socs36e PROPN vx021c20z3n 7 8 , , PUNCT vx021c20z3n 7 9 similar similar ADJ vx021c20z3n 7 10 to to ADP vx021c20z3n 7 11 its its PRON vx021c20z3n 7 12 human human ADJ vx021c20z3n 7 13 homolog homolog NOUN vx021c20z3n 7 14 socs5 socs5 PROPN vx021c20z3n 7 15 , , PUNCT vx021c20z3n 7 16 acts act VERB vx021c20z3n 7 17 as as ADP vx021c20z3n 7 18 a a DET vx021c20z3n 7 19 tumor tumor NOUN vx021c20z3n 7 20 suppressor suppressor NOUN vx021c20z3n 7 21 , , PUNCT vx021c20z3n 7 22 consequently consequently ADV vx021c20z3n 7 23 leading lead VERB vx021c20z3n 7 24 to to ADP vx021c20z3n 7 25 suppression suppression NOUN vx021c20z3n 7 26 of of ADP vx021c20z3n 7 27 the the DET vx021c20z3n 7 28 expanded expand VERB vx021c20z3n 7 29 niche niche NOUN vx021c20z3n 7 30 phenotype phenotype NOUN vx021c20z3n 7 31 . . PUNCT vx021c20z3n 8 1 importantly importantly ADV vx021c20z3n 8 2 , , PUNCT vx021c20z3n 8 3 bantam bantam NOUN vx021c20z3n 8 4 is be AUX vx021c20z3n 8 5 able able ADJ vx021c20z3n 8 6 to to PART vx021c20z3n 8 7 relieve relieve VERB vx021c20z3n 8 8 this this DET vx021c20z3n 8 9 inhibition inhibition NOUN vx021c20z3n 8 10 to to PART vx021c20z3n 8 11 enable enable VERB vx021c20z3n 8 12 massive massive ADJ vx021c20z3n 8 13 niche niche NOUN vx021c20z3n 8 14 overgrowth overgrowth NOUN vx021c20z3n 8 15 . . PUNCT vx021c20z3n 9 1 taken take VERB vx021c20z3n 9 2 together together ADV vx021c20z3n 9 3 , , PUNCT vx021c20z3n 9 4 this this PRON vx021c20z3n 9 5 signifies signify VERB vx021c20z3n 9 6 novel novel ADJ vx021c20z3n 9 7 roles role NOUN vx021c20z3n 9 8 for for ADP vx021c20z3n 9 9 bantam bantam NOUN vx021c20z3n 9 10 , , PUNCT vx021c20z3n 9 11 socs36e socs36e PROPN vx021c20z3n 9 12 , , PUNCT vx021c20z3n 9 13 and and CCONJ vx021c20z3n 9 14 egfr egfr PROPN vx021c20z3n 9 15 in in ADP vx021c20z3n 9 16 the the DET vx021c20z3n 9 17 psc psc PROPN vx021c20z3n 9 18 and and CCONJ vx021c20z3n 9 19 provide provide VERB vx021c20z3n 9 20 a a DET vx021c20z3n 9 21 mechanism mechanism NOUN vx021c20z3n 9 22 and and CCONJ vx021c20z3n 9 23 pathway pathway NOUN vx021c20z3n 9 24 in in ADP vx021c20z3n 9 25 which which PRON vx021c20z3n 9 26 bantam bantam NOUN vx021c20z3n 9 27 operates operate VERB vx021c20z3n 9 28 during during ADP vx021c20z3n 9 29 blood blood NOUN vx021c20z3n 9 30 development development NOUN vx021c20z3n 9 31 . . PUNCT vx021c20z3n 10 1 these these DET vx021c20z3n 10 2 findings finding NOUN vx021c20z3n 10 3 support support VERB vx021c20z3n 10 4 the the DET vx021c20z3n 10 5 study study NOUN vx021c20z3n 10 6 of of ADP vx021c20z3n 10 7 mirnas mirnas PROPN vx021c20z3n 10 8 as as ADP vx021c20z3n 10 9 a a DET vx021c20z3n 10 10 promising promising ADJ vx021c20z3n 10 11 approach approach NOUN vx021c20z3n 10 12 for for ADP vx021c20z3n 10 13 further further ADJ vx021c20z3n 10 14 discovery discovery NOUN vx021c20z3n 10 15 of of ADP vx021c20z3n 10 16 genes gene NOUN vx021c20z3n 10 17 related relate VERB vx021c20z3n 10 18 to to ADP vx021c20z3n 10 19 tumor tumor NOUN vx021c20z3n 10 20 suppression suppression NOUN vx021c20z3n 10 21 or or CCONJ vx021c20z3n 10 22 oncogenesis oncogenesis NOUN vx021c20z3n 10 23 during during ADP vx021c20z3n 10 24 blood blood NOUN vx021c20z3n 10 25 development development NOUN vx021c20z3n 10 26 and and CCONJ vx021c20z3n 10 27 a a DET vx021c20z3n 10 28 means mean NOUN vx021c20z3n 10 29 through through ADP vx021c20z3n 10 30 which which PRON vx021c20z3n 10 31 to to PART vx021c20z3n 10 32 gain gain VERB vx021c20z3n 10 33 valuable valuable ADJ vx021c20z3n 10 34 insights insight NOUN vx021c20z3n 10 35 into into ADP vx021c20z3n 10 36 the the DET vx021c20z3n 10 37 factors factor NOUN vx021c20z3n 10 38 that that PRON vx021c20z3n 10 39 cooperate cooperate VERB vx021c20z3n 10 40 to to PART vx021c20z3n 10 41 maintain maintain VERB vx021c20z3n 10 42 proper proper ADJ vx021c20z3n 10 43 hematopoietic hematopoietic ADJ vx021c20z3n 10 44 homeostasis homeostasis NOUN vx021c20z3n 10 45 . . PUNCT vx021c20z3n 11 1 lastly lastly ADV vx021c20z3n 11 2 , , PUNCT vx021c20z3n 11 3 during during ADP vx021c20z3n 11 4 the the DET vx021c20z3n 11 5 study study NOUN vx021c20z3n 11 6 of of ADP vx021c20z3n 11 7 blood blood NOUN vx021c20z3n 11 8 cell cell NOUN vx021c20z3n 11 9 lineages lineage NOUN vx021c20z3n 11 10 in in ADP vx021c20z3n 11 11 drosophila drosophila NOUN vx021c20z3n 11 12 , , PUNCT vx021c20z3n 11 13 i i PRON vx021c20z3n 11 14 created create VERB vx021c20z3n 11 15 a a DET vx021c20z3n 11 16 novel novel ADJ vx021c20z3n 11 17 tool tool NOUN vx021c20z3n 11 18 for for ADP vx021c20z3n 11 19 developmental developmental ADJ vx021c20z3n 11 20 biologists biologist NOUN vx021c20z3n 11 21 . . PUNCT vx021c20z3n 12 1 m2(h37a)-mediated m2(h37a)-mediated ADJ vx021c20z3n 12 2 ablation ablation NOUN vx021c20z3n 12 3 can can AUX vx021c20z3n 12 4 be be AUX vx021c20z3n 12 5 used use VERB vx021c20z3n 12 6 for for ADP vx021c20z3n 12 7 determining determine VERB vx021c20z3n 12 8 the the DET vx021c20z3n 12 9 interdependent interdependent ADJ vx021c20z3n 12 10 relationships relationship NOUN vx021c20z3n 12 11 between between ADP vx021c20z3n 12 12 cell cell NOUN vx021c20z3n 12 13 populations population NOUN vx021c20z3n 12 14 during during ADP vx021c20z3n 12 15 development development NOUN vx021c20z3n 12 16 that that PRON vx021c20z3n 12 17 can can AUX vx021c20z3n 12 18 be be AUX vx021c20z3n 12 19 applied apply VERB vx021c20z3n 12 20 to to ADP vx021c20z3n 12 21 not not PART vx021c20z3n 12 22 just just ADV vx021c20z3n 12 23 the the DET vx021c20z3n 12 24 blood blood NOUN vx021c20z3n 12 25 system system NOUN vx021c20z3n 12 26 but but CCONJ vx021c20z3n 12 27 any any DET vx021c20z3n 12 28 cell cell NOUN vx021c20z3n 12 29 linage linage NOUN vx021c20z3n 12 30 within within ADP vx021c20z3n 12 31 the the DET vx021c20z3n 12 32 organism organism NOUN vx021c20z3n 12 33 . . PUNCT