id sid tid token lemma pos vt150g37m7v 1 1 the the DET vt150g37m7v 1 2 polyketide polyketide PROPN vt150g37m7v 1 3 apoptolidin apoptolidin PROPN vt150g37m7v 1 4 is be AUX vt150g37m7v 1 5 an an DET vt150g37m7v 1 6 example example NOUN vt150g37m7v 1 7 from from ADP vt150g37m7v 1 8 a a DET vt150g37m7v 1 9 class class NOUN vt150g37m7v 1 10 a a DET vt150g37m7v 1 11 class class NOUN vt150g37m7v 1 12 of of ADP vt150g37m7v 1 13 20 20 NUM vt150g37m7v 1 14 - - PUNCT vt150g37m7v 1 15 membered membere VERB vt150g37m7v 1 16 macrolides macrolide NOUN vt150g37m7v 1 17 with with ADP vt150g37m7v 1 18 potent potent ADJ vt150g37m7v 1 19 and and CCONJ vt150g37m7v 1 20 selective selective ADJ vt150g37m7v 1 21 apoptosis apoptosis NOUN vt150g37m7v 1 22 - - PUNCT vt150g37m7v 1 23 inducing induce VERB vt150g37m7v 1 24 activity activity NOUN vt150g37m7v 1 25 and and CCONJ vt150g37m7v 1 26 are be AUX vt150g37m7v 1 27 believed believe VERB vt150g37m7v 1 28 to to PART vt150g37m7v 1 29 be be AUX vt150g37m7v 1 30 f f X vt150g37m7v 1 31 - - PUNCT vt150g37m7v 1 32 atpase atpase ADJ vt150g37m7v 1 33 inhibitors inhibitor NOUN vt150g37m7v 1 34 . . PUNCT vt150g37m7v 2 1 apoptolidin apoptolidin VERB vt150g37m7v 2 2 purportedly purportedly ADV vt150g37m7v 2 3 targets target VERB vt150g37m7v 2 4 mitochondrial mitochondrial ADJ vt150g37m7v 2 5 f0f1 f0f1 SPACE vt150g37m7v 2 6 - - PUNCT vt150g37m7v 2 7 atpase atpase PROPN vt150g37m7v 2 8 ( ( PUNCT vt150g37m7v 2 9 f f PROPN vt150g37m7v 2 10 - - PUNCT vt150g37m7v 2 11 atpase atpase PROPN vt150g37m7v 2 12 ) ) PUNCT vt150g37m7v 2 13 and and CCONJ vt150g37m7v 2 14 induces induce VERB vt150g37m7v 2 15 apoptosis apoptosis NOUN vt150g37m7v 2 16 selectively selectively ADV vt150g37m7v 2 17 in in ADP vt150g37m7v 2 18 cells cell NOUN vt150g37m7v 2 19 transformed transform VERB vt150g37m7v 2 20 with with ADP vt150g37m7v 2 21 the the DET vt150g37m7v 2 22 adenovirus adenovirus NOUN vt150g37m7v 2 23 oncogene oncogene NOUN vt150g37m7v 2 24 , , PUNCT vt150g37m7v 2 25 leaving leave VERB vt150g37m7v 2 26 normal normal ADJ vt150g37m7v 2 27 cells cell NOUN vt150g37m7v 2 28 unaffected unaffected ADJ vt150g37m7v 2 29 . . PUNCT vt150g37m7v 3 1 apoptolidin apoptolidin ADJ vt150g37m7v 3 2 retains retain VERB vt150g37m7v 3 3 activity activity NOUN vt150g37m7v 3 4 in in ADP vt150g37m7v 3 5 concentrations concentration NOUN vt150g37m7v 3 6 as as ADV vt150g37m7v 3 7 low low ADJ vt150g37m7v 3 8 as as ADP vt150g37m7v 3 9 10 10 NUM vt150g37m7v 3 10 nm nm NOUN vt150g37m7v 3 11 ; ; PUNCT vt150g37m7v 3 12 normal normal ADJ vt150g37m7v 3 13 cells cell NOUN vt150g37m7v 3 14 remain remain VERB vt150g37m7v 3 15 unaffected unaffected ADJ vt150g37m7v 3 16 at at ADP vt150g37m7v 3 17 concentrations concentration NOUN vt150g37m7v 3 18 as as ADV vt150g37m7v 3 19 high high ADJ vt150g37m7v 3 20 as as ADP vt150g37m7v 3 21 80åµm 80åµm ADJ vt150g37m7v 3 22 . . PUNCT vt150g37m7v 4 1 unfortunately unfortunately ADV vt150g37m7v 4 2 , , PUNCT vt150g37m7v 4 3 wender wender NOUN vt150g37m7v 4 4 and and CCONJ vt150g37m7v 4 5 sulikowski sulikowski PROPN vt150g37m7v 4 6 independently independently ADV vt150g37m7v 4 7 demonstrated demonstrate VERB vt150g37m7v 4 8 the the DET vt150g37m7v 4 9 ring ring NOUN vt150g37m7v 4 10 expansion expansion NOUN vt150g37m7v 4 11 - - PUNCT vt150g37m7v 4 12 isomerization isomerization NOUN vt150g37m7v 4 13 of of ADP vt150g37m7v 4 14 apoptolidin apoptolidin VERB vt150g37m7v 4 15 a a PRON vt150g37m7v 4 16 via via ADP vt150g37m7v 4 17 an an DET vt150g37m7v 4 18 acyl acyl NOUN vt150g37m7v 4 19 migration migration NOUN vt150g37m7v 4 20 of of ADP vt150g37m7v 4 21 the the DET vt150g37m7v 4 22 c20 c20 PROPN vt150g37m7v 4 23 - - PUNCT vt150g37m7v 4 24 hydroxyl hydroxyl PROPN vt150g37m7v 4 25 group group PROPN vt150g37m7v 4 26 to to PART vt150g37m7v 4 27 form form VERB vt150g37m7v 4 28 a a DET vt150g37m7v 4 29 less less ADV vt150g37m7v 4 30 active active ADJ vt150g37m7v 4 31 congener congener NOUN vt150g37m7v 4 32 , , PUNCT vt150g37m7v 4 33 isoapoptolidin isoapoptolidin PROPN vt150g37m7v 4 34 . . PUNCT vt150g37m7v 5 1 isoapoptolidin isoapoptolidin PROPN vt150g37m7v 5 2 was be AUX vt150g37m7v 5 3 found find VERB vt150g37m7v 5 4 to to PART vt150g37m7v 5 5 be be AUX vt150g37m7v 5 6 considerably considerably ADV vt150g37m7v 5 7 less less ADV vt150g37m7v 5 8 active active ADJ vt150g37m7v 5 9 than than ADP vt150g37m7v 5 10 apoptolidin apoptolidin VERB vt150g37m7v 5 11 and and CCONJ vt150g37m7v 5 12 the the DET vt150g37m7v 5 13 lack lack NOUN vt150g37m7v 5 14 of of ADP vt150g37m7v 5 15 a a DET vt150g37m7v 5 16 c20 c20 PROPN vt150g37m7v 5 17 - - PUNCT vt150g37m7v 5 18 hydroxyl hydroxyl PROPN vt150g37m7v 5 19 group group PROPN vt150g37m7v 5 20 could could AUX vt150g37m7v 5 21 explain explain VERB vt150g37m7v 5 22 the the DET vt150g37m7v 5 23 increased increase VERB vt150g37m7v 5 24 biological biological ADJ vt150g37m7v 5 25 activity activity NOUN vt150g37m7v 5 26 of of ADP vt150g37m7v 5 27 apoptolidin apoptolidin VERB vt150g37m7v 5 28 c c PROPN vt150g37m7v 5 29 in in ADP vt150g37m7v 5 30 cell cell NOUN vt150g37m7v 5 31 - - PUNCT vt150g37m7v 5 32 based base VERB vt150g37m7v 5 33 assays assay NOUN vt150g37m7v 5 34 . . PUNCT vt150g37m7v 6 1 we we PRON vt150g37m7v 6 2 have have AUX vt150g37m7v 6 3 targeted target VERB vt150g37m7v 6 4 the the DET vt150g37m7v 6 5 total total ADJ vt150g37m7v 6 6 synthesis synthesis NOUN vt150g37m7v 6 7 of of ADP vt150g37m7v 6 8 20 20 NUM vt150g37m7v 6 9 - - PUNCT vt150g37m7v 6 10 deoxyapoptolidin deoxyapoptolidin NOUN vt150g37m7v 6 11 because because SCONJ vt150g37m7v 6 12 of of ADP vt150g37m7v 6 13 the the DET vt150g37m7v 6 14 potential potential NOUN vt150g37m7v 6 15 of of ADP vt150g37m7v 6 16 increased increase VERB vt150g37m7v 6 17 chemical chemical ADJ vt150g37m7v 6 18 stability stability NOUN vt150g37m7v 6 19 . . PUNCT vt150g37m7v 7 1 in in ADP vt150g37m7v 7 2 addition addition NOUN vt150g37m7v 7 3 to to ADP vt150g37m7v 7 4 the the DET vt150g37m7v 7 5 increased increase VERB vt150g37m7v 7 6 stability stability NOUN vt150g37m7v 7 7 , , PUNCT vt150g37m7v 7 8 20 20 NUM vt150g37m7v 7 9 - - PUNCT vt150g37m7v 7 10 deoxyapoptolidinone deoxyapoptolidinone PROPN vt150g37m7v 7 11 may may AUX vt150g37m7v 7 12 be be AUX vt150g37m7v 7 13 a a DET vt150g37m7v 7 14 unique unique ADJ vt150g37m7v 7 15 chemical chemical NOUN vt150g37m7v 7 16 entity entity NOUN vt150g37m7v 7 17 . . PUNCT vt150g37m7v 8 1 noticeably noticeably ADV vt150g37m7v 8 2 absent absent ADJ vt150g37m7v 8 3 from from ADP vt150g37m7v 8 4 the the DET vt150g37m7v 8 5 family family NOUN vt150g37m7v 8 6 of of ADP vt150g37m7v 8 7 natural natural ADJ vt150g37m7v 8 8 apoptolidin apoptolidin ADJ vt150g37m7v 8 9 congeners congener NOUN vt150g37m7v 8 10 is be AUX vt150g37m7v 8 11 c20 c20 NOUN vt150g37m7v 8 12 - - PUNCT vt150g37m7v 8 13 deoxyapoptolidin deoxyapoptolidin PROPN vt150g37m7v 8 14 . . PUNCT vt150g37m7v 9 1 the the DET vt150g37m7v 9 2 lack lack NOUN vt150g37m7v 9 3 of of ADP vt150g37m7v 9 4 c20 c20 NOUN vt150g37m7v 9 5 oxygenation oxygenation NOUN vt150g37m7v 9 6 also also ADV vt150g37m7v 9 7 represents represent VERB vt150g37m7v 9 8 a a DET vt150g37m7v 9 9 unique unique ADJ vt150g37m7v 9 10 structure structure NOUN vt150g37m7v 9 11 that that PRON vt150g37m7v 9 12 may may AUX vt150g37m7v 9 13 not not PART vt150g37m7v 9 14 be be AUX vt150g37m7v 9 15 accessible accessible ADJ vt150g37m7v 9 16 by by ADP vt150g37m7v 9 17 nocardiopsis nocardiopsis NOUN vt150g37m7v 9 18 sp sp NOUN vt150g37m7v 9 19 . . PROPN vt150g37m7v 9 20 , , PUNCT vt150g37m7v 9 21 the the DET vt150g37m7v 9 22 naturally naturally ADV vt150g37m7v 9 23 producing produce VERB vt150g37m7v 9 24 organism organism NOUN vt150g37m7v 9 25 . . PUNCT vt150g37m7v 10 1 herein herein ADV vt150g37m7v 10 2 , , PUNCT vt150g37m7v 10 3 we we PRON vt150g37m7v 10 4 present present VERB vt150g37m7v 10 5 an an DET vt150g37m7v 10 6 asymmetric asymmetric ADJ vt150g37m7v 10 7 route route NOUN vt150g37m7v 10 8 to to ADP vt150g37m7v 10 9 the the DET vt150g37m7v 10 10 aglycone aglycone NOUN vt150g37m7v 10 11 of of ADP vt150g37m7v 10 12 20 20 NUM vt150g37m7v 10 13 - - PUNCT vt150g37m7v 10 14 deoxyapoptolidinone deoxyapoptolidinone NOUN vt150g37m7v 10 15 . . PUNCT vt150g37m7v 11 1 the the DET vt150g37m7v 11 2 algycone algycone PROPN vt150g37m7v 11 3 was be AUX vt150g37m7v 11 4 chosen choose VERB vt150g37m7v 11 5 as as ADP vt150g37m7v 11 6 an an DET vt150g37m7v 11 7 initial initial ADJ vt150g37m7v 11 8 target target NOUN vt150g37m7v 11 9 to to PART vt150g37m7v 11 10 further far ADV vt150g37m7v 11 11 explore explore VERB vt150g37m7v 11 12 the the DET vt150g37m7v 11 13 biological biological ADJ vt150g37m7v 11 14 significance significance NOUN vt150g37m7v 11 15 of of ADP vt150g37m7v 11 16 post post ADJ vt150g37m7v 11 17 - - ADJ vt150g37m7v 11 18 pks pks ADJ vt150g37m7v 11 19 modifications modification NOUN vt150g37m7v 11 20 . . PUNCT