id sid tid token lemma pos vq27zk54d78 1 1 normal normal ADJ vq27zk54d78 1 2 epithelial epithelial ADJ vq27zk54d78 1 3 cells cell NOUN vq27zk54d78 1 4 require require VERB vq27zk54d78 1 5 attachment attachment NOUN vq27zk54d78 1 6 to to ADP vq27zk54d78 1 7 the the DET vq27zk54d78 1 8 extracellular extracellular ADJ vq27zk54d78 1 9 matrix matrix NOUN vq27zk54d78 1 10 ( ( PUNCT vq27zk54d78 1 11 ecm ecm NOUN vq27zk54d78 1 12 ) ) PUNCT vq27zk54d78 1 13 in in ADP vq27zk54d78 1 14 order order NOUN vq27zk54d78 1 15 to to PART vq27zk54d78 1 16 proliferate proliferate VERB vq27zk54d78 1 17 and and CCONJ vq27zk54d78 1 18 survive survive VERB vq27zk54d78 1 19 . . PUNCT vq27zk54d78 2 1 binding bind VERB vq27zk54d78 2 2 to to ADP vq27zk54d78 2 3 the the DET vq27zk54d78 2 4 ecm ecm NOUN vq27zk54d78 2 5 facilitates facilitate VERB vq27zk54d78 2 6 the the DET vq27zk54d78 2 7 activation activation NOUN vq27zk54d78 2 8 of of ADP vq27zk54d78 2 9 pathways pathway NOUN vq27zk54d78 2 10 responsible responsible ADJ vq27zk54d78 2 11 for for ADP vq27zk54d78 2 12 atp atp PROPN vq27zk54d78 2 13 production production NOUN vq27zk54d78 2 14 and and CCONJ vq27zk54d78 2 15 cell cell NOUN vq27zk54d78 2 16 survival survival NOUN vq27zk54d78 2 17 . . PUNCT vq27zk54d78 3 1 when when SCONJ vq27zk54d78 3 2 detached detach VERB vq27zk54d78 3 3 from from ADP vq27zk54d78 3 4 the the DET vq27zk54d78 3 5 ecm ecm NOUN vq27zk54d78 3 6 , , PUNCT vq27zk54d78 3 7 normal normal ADJ vq27zk54d78 3 8 cells cell NOUN vq27zk54d78 3 9 will will AUX vq27zk54d78 3 10 upregulate upregulate VERB vq27zk54d78 3 11 apoptotic apoptotic ADJ vq27zk54d78 3 12 pathways pathway NOUN vq27zk54d78 3 13 and and CCONJ vq27zk54d78 3 14 will will AUX vq27zk54d78 3 15 be be AUX vq27zk54d78 3 16 systematically systematically ADV vq27zk54d78 3 17 removed remove VERB vq27zk54d78 3 18 . . PUNCT vq27zk54d78 4 1 this this DET vq27zk54d78 4 2 detachment detachment NOUN vq27zk54d78 4 3 - - PUNCT vq27zk54d78 4 4 induced induce VERB vq27zk54d78 4 5 apoptosis apoptosis NOUN vq27zk54d78 4 6 is be AUX vq27zk54d78 4 7 known know VERB vq27zk54d78 4 8 as as ADP vq27zk54d78 4 9 anoikis anoiki NOUN vq27zk54d78 4 10 . . PUNCT vq27zk54d78 5 1 ecm ecm PROPN vq27zk54d78 5 2 detachment detachment PROPN vq27zk54d78 5 3 in in ADP vq27zk54d78 5 4 normal normal ADJ vq27zk54d78 5 5 epithelial epithelial ADJ vq27zk54d78 5 6 cells cell NOUN vq27zk54d78 5 7 disrupts disrupt VERB vq27zk54d78 5 8 cellular cellular ADJ vq27zk54d78 5 9 signaling signaling NOUN vq27zk54d78 5 10 derived derive VERB vq27zk54d78 5 11 from from ADP vq27zk54d78 5 12 integrin integrin PROPN vq27zk54d78 5 13 - - PUNCT vq27zk54d78 5 14 mediated mediate VERB vq27zk54d78 5 15 basal basal ADJ vq27zk54d78 5 16 attachment attachment NOUN vq27zk54d78 5 17 as as ADV vq27zk54d78 5 18 well well ADV vq27zk54d78 5 19 as as ADP vq27zk54d78 5 20 cadherin cadherin NOUN vq27zk54d78 5 21 assisted assist VERB vq27zk54d78 5 22 signaling signal VERB vq27zk54d78 5 23 from from ADP vq27zk54d78 5 24 lateral lateral ADJ vq27zk54d78 5 25 cell cell NOUN vq27zk54d78 5 26 contacts contact NOUN vq27zk54d78 5 27 . . PUNCT vq27zk54d78 6 1 it it PRON vq27zk54d78 6 2 has have AUX vq27zk54d78 6 3 been be AUX vq27zk54d78 6 4 well well ADV vq27zk54d78 6 5 established establish VERB vq27zk54d78 6 6 by by ADP vq27zk54d78 6 7 countless countless ADJ vq27zk54d78 6 8 studies study NOUN vq27zk54d78 6 9 that that SCONJ vq27zk54d78 6 10 the the DET vq27zk54d78 6 11 overexpression overexpression NOUN vq27zk54d78 6 12 of of ADP vq27zk54d78 6 13 oncogenes oncogene NOUN vq27zk54d78 6 14 can can AUX vq27zk54d78 6 15 facilitate facilitate VERB vq27zk54d78 6 16 the the DET vq27zk54d78 6 17 ability ability NOUN vq27zk54d78 6 18 of of ADP vq27zk54d78 6 19 ecm ecm NOUN vq27zk54d78 6 20 - - PUNCT vq27zk54d78 6 21 detached detach VERB vq27zk54d78 6 22 cells cell NOUN vq27zk54d78 6 23 to to PART vq27zk54d78 6 24 avoid avoid VERB vq27zk54d78 6 25 anoikis anoiki NOUN vq27zk54d78 6 26 . . PUNCT vq27zk54d78 7 1 erbb2 erbb2 PROPN vq27zk54d78 7 2 and and CCONJ vq27zk54d78 7 3 ras ras PROPN vq27zk54d78 7 4 are be AUX vq27zk54d78 7 5 two two NUM vq27zk54d78 7 6 oncogenes oncogene NOUN vq27zk54d78 7 7 that that PRON vq27zk54d78 7 8 have have AUX vq27zk54d78 7 9 been be AUX vq27zk54d78 7 10 implicated implicate VERB vq27zk54d78 7 11 in in ADP vq27zk54d78 7 12 the the DET vq27zk54d78 7 13 ability ability NOUN vq27zk54d78 7 14 of of ADP vq27zk54d78 7 15 cancer cancer NOUN vq27zk54d78 7 16 cells cell NOUN vq27zk54d78 7 17 to to PART vq27zk54d78 7 18 avoid avoid VERB vq27zk54d78 7 19 anoikis anoiki NOUN vq27zk54d78 7 20 . . PUNCT vq27zk54d78 8 1 erbb2 erbb2 PROPN vq27zk54d78 8 2 is be AUX vq27zk54d78 8 3 an an DET vq27zk54d78 8 4 orphan orphan NOUN vq27zk54d78 8 5 member member NOUN vq27zk54d78 8 6 of of ADP vq27zk54d78 8 7 the the DET vq27zk54d78 8 8 egfr egfr PROPN vq27zk54d78 8 9 family family NOUN vq27zk54d78 8 10 of of ADP vq27zk54d78 8 11 tyrosine tyrosine NOUN vq27zk54d78 8 12 kinases kinase NOUN vq27zk54d78 8 13 and and CCONJ vq27zk54d78 8 14 is be AUX vq27zk54d78 8 15 a a DET vq27zk54d78 8 16 potent potent ADJ vq27zk54d78 8 17 oncogene oncogene NOUN vq27zk54d78 8 18 found find VERB vq27zk54d78 8 19 in in ADP vq27zk54d78 8 20 30 30 NUM vq27zk54d78 8 21 % % NOUN vq27zk54d78 8 22 of of ADP vq27zk54d78 8 23 all all DET vq27zk54d78 8 24 breast breast NOUN vq27zk54d78 8 25 cancer cancer NOUN vq27zk54d78 8 26 tissue tissue NOUN vq27zk54d78 8 27 . . PUNCT vq27zk54d78 9 1 previous previous ADJ vq27zk54d78 9 2 studies study NOUN vq27zk54d78 9 3 in in ADP vq27zk54d78 9 4 our our PRON vq27zk54d78 9 5 laboratory laboratory NOUN vq27zk54d78 9 6 have have AUX vq27zk54d78 9 7 found find VERB vq27zk54d78 9 8 a a DET vq27zk54d78 9 9 direct direct ADJ vq27zk54d78 9 10 correlation correlation NOUN vq27zk54d78 9 11 between between ADP vq27zk54d78 9 12 upregulation upregulation NOUN vq27zk54d78 9 13 of of ADP vq27zk54d78 9 14 survival survival NOUN vq27zk54d78 9 15 pathways pathway NOUN vq27zk54d78 9 16 in in ADP vq27zk54d78 9 17 ecm ecm NOUN vq27zk54d78 9 18 detached detach VERB vq27zk54d78 9 19 cells cell NOUN vq27zk54d78 9 20 and and CCONJ vq27zk54d78 9 21 expression expression NOUN vq27zk54d78 9 22 of of ADP vq27zk54d78 9 23 erbb2 erbb2 PROPN vq27zk54d78 9 24 . . PUNCT vq27zk54d78 9 25 mutated mutate VERB vq27zk54d78 9 26 ras ras PROPN vq27zk54d78 9 27 is be AUX vq27zk54d78 9 28 found find VERB vq27zk54d78 9 29 in in ADP vq27zk54d78 9 30 up up ADP vq27zk54d78 9 31 to to PART vq27zk54d78 9 32 30 30 NUM vq27zk54d78 9 33 % % NOUN vq27zk54d78 9 34 of of ADP vq27zk54d78 9 35 all all DET vq27zk54d78 9 36 human human ADJ vq27zk54d78 9 37 cancers cancer NOUN vq27zk54d78 9 38 and and CCONJ vq27zk54d78 9 39 is be AUX vq27zk54d78 9 40 commonly commonly ADV vq27zk54d78 9 41 found find VERB vq27zk54d78 9 42 overexpressed overexpresse VERB vq27zk54d78 9 43 in in ADP vq27zk54d78 9 44 a a DET vq27zk54d78 9 45 multitude multitude NOUN vq27zk54d78 9 46 of of ADP vq27zk54d78 9 47 cancers cancer NOUN vq27zk54d78 9 48 such such ADJ vq27zk54d78 9 49 as as ADP vq27zk54d78 9 50 pancreatic pancreatic ADJ vq27zk54d78 9 51 and and CCONJ vq27zk54d78 9 52 colon colon NOUN vq27zk54d78 9 53 cancers cancer NOUN vq27zk54d78 9 54 . . PUNCT vq27zk54d78 10 1 although although SCONJ vq27zk54d78 10 2 it it PRON vq27zk54d78 10 3 is be AUX vq27zk54d78 10 4 rare rare ADJ vq27zk54d78 10 5 in in ADP vq27zk54d78 10 6 breast breast NOUN vq27zk54d78 10 7 cancers cancer NOUN vq27zk54d78 10 8 and and CCONJ vq27zk54d78 10 9 found find VERB vq27zk54d78 10 10 mutated mutate VERB vq27zk54d78 10 11 in in ADP vq27zk54d78 10 12 only only ADV vq27zk54d78 10 13 5 5 NUM vq27zk54d78 10 14 % % NOUN vq27zk54d78 10 15 of of ADP vq27zk54d78 10 16 breast breast NOUN vq27zk54d78 10 17 cancer cancer NOUN vq27zk54d78 10 18 diagnoses diagnosis NOUN vq27zk54d78 10 19 , , PUNCT vq27zk54d78 10 20 ras ras NOUN vq27zk54d78 10 21 signaling signaling NOUN vq27zk54d78 10 22 can can AUX vq27zk54d78 10 23 be be AUX vq27zk54d78 10 24 driven drive VERB vq27zk54d78 10 25 considerably considerably ADV vq27zk54d78 10 26 by by ADP vq27zk54d78 10 27 multiple multiple ADJ vq27zk54d78 10 28 growth growth NOUN vq27zk54d78 10 29 factors factor NOUN vq27zk54d78 10 30 , , PUNCT vq27zk54d78 10 31 such such ADJ vq27zk54d78 10 32 as as ADP vq27zk54d78 10 33 erbb2 erbb2 PROPN vq27zk54d78 10 34 . . PUNCT vq27zk54d78 11 1 this this PRON vq27zk54d78 11 2 makes make VERB vq27zk54d78 11 3 ras ras NOUN vq27zk54d78 11 4 - - PUNCT vq27zk54d78 11 5 driven drive VERB vq27zk54d78 11 6 signaling signal VERB vq27zk54d78 11 7 an an DET vq27zk54d78 11 8 important important ADJ vq27zk54d78 11 9 factor factor NOUN vq27zk54d78 11 10 in in ADP vq27zk54d78 11 11 disease disease NOUN vq27zk54d78 11 12 progression progression NOUN vq27zk54d78 11 13 . . PUNCT vq27zk54d78 12 1 previous previous ADJ vq27zk54d78 12 2 literature literature NOUN vq27zk54d78 12 3 has have AUX vq27zk54d78 12 4 shown show VERB vq27zk54d78 12 5 that that SCONJ vq27zk54d78 12 6 erbb2 erbb2 PROPN vq27zk54d78 12 7 and and CCONJ vq27zk54d78 12 8 ras ras PROPN vq27zk54d78 12 9 regulate regulate VERB vq27zk54d78 12 10 cytochrome cytochrome NOUN vq27zk54d78 12 11 c c NOUN vq27zk54d78 12 12 release release NOUN vq27zk54d78 12 13 from from ADP vq27zk54d78 12 14 the the DET vq27zk54d78 12 15 mitochondria mitochondria NOUN vq27zk54d78 12 16 by by ADP vq27zk54d78 12 17 regulating regulate VERB vq27zk54d78 12 18 the the DET vq27zk54d78 12 19 action action NOUN vq27zk54d78 12 20 of of ADP vq27zk54d78 12 21 bcl-2 bcl-2 PART vq27zk54d78 12 22 proteins protein NOUN vq27zk54d78 12 23 via via ADP vq27zk54d78 12 24 the the DET vq27zk54d78 12 25 stimulation stimulation NOUN vq27zk54d78 12 26 of of ADP vq27zk54d78 12 27 multiple multiple ADJ vq27zk54d78 12 28 survival survival NOUN vq27zk54d78 12 29 kinase kinase NOUN vq27zk54d78 12 30 pathways pathway NOUN vq27zk54d78 12 31 . . PUNCT vq27zk54d78 13 1 my my PRON vq27zk54d78 13 2 studies study NOUN vq27zk54d78 13 3 have have AUX vq27zk54d78 13 4 found find VERB vq27zk54d78 13 5 that that SCONJ vq27zk54d78 13 6 the the DET vq27zk54d78 13 7 overexpression overexpression NOUN vq27zk54d78 13 8 of of ADP vq27zk54d78 13 9 erbb2 erbb2 PROPN vq27zk54d78 13 10 in in ADP vq27zk54d78 13 11 non non ADJ vq27zk54d78 13 12 - - ADJ vq27zk54d78 13 13 malignant malignant ADJ vq27zk54d78 13 14 mammary mammary ADJ vq27zk54d78 13 15 epithelial epithelial ADJ vq27zk54d78 13 16 cells cell NOUN vq27zk54d78 13 17 ( ( PUNCT vq27zk54d78 13 18 mcf-10a mcf-10a NOUN vq27zk54d78 13 19 ) ) PUNCT vq27zk54d78 13 20 results result NOUN vq27zk54d78 13 21 in in ADP vq27zk54d78 13 22 substantial substantial ADJ vq27zk54d78 13 23 aggregation aggregation NOUN vq27zk54d78 13 24 of of ADP vq27zk54d78 13 25 detached detached ADJ vq27zk54d78 13 26 cells cell NOUN vq27zk54d78 13 27 and and CCONJ vq27zk54d78 13 28 the the DET vq27zk54d78 13 29 inhibition inhibition NOUN vq27zk54d78 13 30 of of ADP vq27zk54d78 13 31 caspase caspase NOUN vq27zk54d78 13 32 activation activation NOUN vq27zk54d78 13 33 . . PUNCT vq27zk54d78 14 1 these these DET vq27zk54d78 14 2 data datum NOUN vq27zk54d78 14 3 suggest suggest VERB vq27zk54d78 14 4 that that SCONJ vq27zk54d78 14 5 erbb2 erbb2 PROPN vq27zk54d78 14 6 plays play VERB vq27zk54d78 14 7 a a DET vq27zk54d78 14 8 role role NOUN vq27zk54d78 14 9 in in ADP vq27zk54d78 14 10 protecting protect VERB vq27zk54d78 14 11 detached detached ADJ vq27zk54d78 14 12 cells cell NOUN vq27zk54d78 14 13 from from ADP vq27zk54d78 14 14 anoikis anoiki NOUN vq27zk54d78 14 15 and and CCONJ vq27zk54d78 14 16 this this DET vq27zk54d78 14 17 activity activity NOUN vq27zk54d78 14 18 may may AUX vq27zk54d78 14 19 be be AUX vq27zk54d78 14 20 linked link VERB vq27zk54d78 14 21 to to ADP vq27zk54d78 14 22 cell cell NOUN vq27zk54d78 14 23 - - PUNCT vq27zk54d78 14 24 cell cell NOUN vq27zk54d78 14 25 adhesion adhesion NOUN vq27zk54d78 14 26 in in ADP vq27zk54d78 14 27 suspension suspension NOUN vq27zk54d78 14 28 . . PUNCT vq27zk54d78 15 1 we we PRON vq27zk54d78 15 2 found find VERB vq27zk54d78 15 3 that that SCONJ vq27zk54d78 15 4 the the DET vq27zk54d78 15 5 disruption disruption NOUN vq27zk54d78 15 6 of of ADP vq27zk54d78 15 7 cell cell NOUN vq27zk54d78 15 8 - - PUNCT vq27zk54d78 15 9 cell cell NOUN vq27zk54d78 15 10 contacts contact NOUN vq27zk54d78 15 11 in in ADP vq27zk54d78 15 12 erbb2 erbb2 PROPN vq27zk54d78 15 13 - - PUNCT vq27zk54d78 15 14 overexpressing overexpresse VERB vq27zk54d78 15 15 mcf-10a mcf-10a ADJ vq27zk54d78 15 16 cells cell NOUN vq27zk54d78 15 17 ( ( PUNCT vq27zk54d78 15 18 using use VERB vq27zk54d78 15 19 methylcellulose methylcellulose DET vq27zk54d78 15 20 or or CCONJ vq27zk54d78 15 21 by by ADP vq27zk54d78 15 22 antagonizing antagonize VERB vq27zk54d78 15 23 the the DET vq27zk54d78 15 24 formation formation NOUN vq27zk54d78 15 25 of of ADP vq27zk54d78 15 26 adherens adherens NOUN vq27zk54d78 15 27 junctions junction NOUN vq27zk54d78 15 28 ) ) PUNCT vq27zk54d78 15 29 induces induce VERB vq27zk54d78 15 30 caspase caspase NOUN vq27zk54d78 15 31 activation.furthermore activation.furthermore ADV vq27zk54d78 15 32 , , PUNCT vq27zk54d78 15 33 in in ADP vq27zk54d78 15 34 cells cell NOUN vq27zk54d78 15 35 that that PRON vq27zk54d78 15 36 form form VERB vq27zk54d78 15 37 large large ADJ vq27zk54d78 15 38 aggregates aggregate NOUN vq27zk54d78 15 39 , , PUNCT vq27zk54d78 15 40 erbb2 erbb2 PROPN vq27zk54d78 15 41 can can AUX vq27zk54d78 15 42 interact interact VERB vq27zk54d78 15 43 with with ADP vq27zk54d78 15 44 e e NOUN vq27zk54d78 15 45 - - NOUN vq27zk54d78 15 46 cadherin cadherin NOUN vq27zk54d78 15 47 and and CCONJ vq27zk54d78 15 48 egfr egfr PROPN vq27zk54d78 15 49 in in ADP vq27zk54d78 15 50 a a DET vq27zk54d78 15 51 fashion fashion NOUN vq27zk54d78 15 52 that that PRON vq27zk54d78 15 53 prevents prevent VERB vq27zk54d78 15 54 the the DET vq27zk54d78 15 55 internalization internalization NOUN vq27zk54d78 15 56 of of ADP vq27zk54d78 15 57 egfr egfr PROPN vq27zk54d78 15 58 and and CCONJ vq27zk54d78 15 59 ultimately ultimately ADV vq27zk54d78 15 60 its its PRON vq27zk54d78 15 61 lysosome lysosome NOUN vq27zk54d78 15 62 mediated mediate VERB vq27zk54d78 15 63 degradation degradation NOUN vq27zk54d78 15 64 . . PUNCT vq27zk54d78 16 1 the the DET vq27zk54d78 16 2 disruption disruption NOUN vq27zk54d78 16 3 of of ADP vq27zk54d78 16 4 aggregation aggregation NOUN vq27zk54d78 16 5 causes cause VERB vq27zk54d78 16 6 the the DET vq27zk54d78 16 7 erbb2 erbb2 PROPN vq27zk54d78 16 8 / / SYM vq27zk54d78 16 9 egfr egfr PROPN vq27zk54d78 16 10 / / SYM vq27zk54d78 16 11 e e NOUN vq27zk54d78 16 12 - - ADJ vq27zk54d78 16 13 cadherin cadherin ADJ vq27zk54d78 16 14 complex complex NOUN vq27zk54d78 16 15 to to PART vq27zk54d78 16 16 fail fail VERB vq27zk54d78 16 17 and and CCONJ vq27zk54d78 16 18 subsequently subsequently ADV vq27zk54d78 16 19 results result VERB vq27zk54d78 16 20 in in ADP vq27zk54d78 16 21 egfr egfr PROPN vq27zk54d78 16 22 degradation degradation NOUN vq27zk54d78 16 23 in in ADP vq27zk54d78 16 24 the the DET vq27zk54d78 16 25 lysosome lysosome NOUN vq27zk54d78 16 26 . . PUNCT vq27zk54d78 17 1 this this DET vq27zk54d78 17 2 degradation degradation NOUN vq27zk54d78 17 3 of of ADP vq27zk54d78 17 4 egfr egfr PROPN vq27zk54d78 17 5 diminishes diminish VERB vq27zk54d78 17 6 signaling signal VERB vq27zk54d78 17 7 through through ADP vq27zk54d78 17 8 the the DET vq27zk54d78 17 9 mapk mapk PROPN vq27zk54d78 17 10 pathway pathway PROPN vq27zk54d78 17 11 , , PUNCT vq27zk54d78 17 12 preventing prevent VERB vq27zk54d78 17 13 the the DET vq27zk54d78 17 14 induction induction NOUN vq27zk54d78 17 15 of of ADP vq27zk54d78 17 16 anoikis.in anoikis.in NUM vq27zk54d78 17 17 summary summary NOUN vq27zk54d78 17 18 , , PUNCT vq27zk54d78 17 19 these these DET vq27zk54d78 17 20 data datum NOUN vq27zk54d78 17 21 suggest suggest VERB vq27zk54d78 17 22 that that SCONJ vq27zk54d78 17 23 oncogenic oncogenic NOUN vq27zk54d78 17 24 signaling signal VERB vq27zk54d78 17 25 through through ADP vq27zk54d78 17 26 erbb2 erbb2 PROPN vq27zk54d78 17 27 promotes promote VERB vq27zk54d78 17 28 the the DET vq27zk54d78 17 29 formation formation NOUN vq27zk54d78 17 30 of of ADP vq27zk54d78 17 31 cellular cellular ADJ vq27zk54d78 17 32 aggregates aggregate NOUN vq27zk54d78 17 33 that that PRON vq27zk54d78 17 34 function function VERB vq27zk54d78 17 35 to to PART vq27zk54d78 17 36 prevent prevent VERB vq27zk54d78 17 37 egfr egfr PROPN vq27zk54d78 17 38 from from ADP vq27zk54d78 17 39 degradation degradation NOUN vq27zk54d78 17 40 and and CCONJ vq27zk54d78 17 41 subsequently subsequently ADV vq27zk54d78 17 42 to to PART vq27zk54d78 17 43 block block VERB vq27zk54d78 17 44 the the DET vq27zk54d78 17 45 induction induction NOUN vq27zk54d78 17 46 of of ADP vq27zk54d78 17 47 anoikis anoiki NOUN vq27zk54d78 17 48 . . PUNCT vq27zk54d78 18 1 my my PRON vq27zk54d78 18 2 studies study NOUN vq27zk54d78 18 3 have have AUX vq27zk54d78 18 4 also also ADV vq27zk54d78 18 5 uncovered uncover VERB vq27zk54d78 18 6 that that SCONJ vq27zk54d78 18 7 the the DET vq27zk54d78 18 8 overexpression overexpression NOUN vq27zk54d78 18 9 of of ADP vq27zk54d78 18 10 oncogenic oncogenic ADJ vq27zk54d78 18 11 ras ras NOUN vq27zk54d78 18 12 results result NOUN vq27zk54d78 18 13 in in ADP vq27zk54d78 18 14 decreased decrease VERB vq27zk54d78 18 15 sensitivity sensitivity NOUN vq27zk54d78 18 16 to to ADP vq27zk54d78 18 17 exogenous exogenous ADJ vq27zk54d78 18 18 cytochrome cytochrome NOUN vq27zk54d78 18 19 c c PROPN vq27zk54d78 18 20 in in ADP vq27zk54d78 18 21 ecm ecm NOUN vq27zk54d78 18 22 - - NOUN vq27zk54d78 18 23 detachment detachment NOUN vq27zk54d78 18 24 compared compare VERB vq27zk54d78 18 25 to to ADP vq27zk54d78 18 26 controls control NOUN vq27zk54d78 18 27 . . PUNCT vq27zk54d78 19 1 this this DET vq27zk54d78 19 2 decreased decrease VERB vq27zk54d78 19 3 sensitivity sensitivity NOUN vq27zk54d78 19 4 was be AUX vq27zk54d78 19 5 observed observe VERB vq27zk54d78 19 6 despite despite SCONJ vq27zk54d78 19 7 the the DET vq27zk54d78 19 8 fact fact NOUN vq27zk54d78 19 9 that that SCONJ vq27zk54d78 19 10 there there PRON vq27zk54d78 19 11 is be VERB vq27zk54d78 19 12 an an DET vq27zk54d78 19 13 upregulation upregulation NOUN vq27zk54d78 19 14 of of ADP vq27zk54d78 19 15 apoptosomal apoptosomal ADJ vq27zk54d78 19 16 proteins protein NOUN vq27zk54d78 19 17 in in ADP vq27zk54d78 19 18 ras ras NOUN vq27zk54d78 19 19 cells cell NOUN vq27zk54d78 19 20 in in ADP vq27zk54d78 19 21 a a DET vq27zk54d78 19 22 mapk mapk PROPN vq27zk54d78 19 23 dependent dependent ADJ vq27zk54d78 19 24 manner manner NOUN vq27zk54d78 19 25 . . PUNCT vq27zk54d78 20 1 this this PRON vq27zk54d78 20 2 suggests suggest VERB vq27zk54d78 20 3 that that SCONJ vq27zk54d78 20 4 ras ras PROPN vq27zk54d78 20 5 - - ADJ vq27zk54d78 20 6 hyperactivated hyperactivate VERB vq27zk54d78 20 7 cells cell NOUN vq27zk54d78 20 8 are be AUX vq27zk54d78 20 9 uniquely uniquely ADV vq27zk54d78 20 10 resistant resistant ADJ vq27zk54d78 20 11 to to PART vq27zk54d78 20 12 cytochrome cytochrome VERB vq27zk54d78 20 13 c c NOUN vq27zk54d78 20 14 mediated mediate VERB vq27zk54d78 20 15 cell cell NOUN vq27zk54d78 20 16 death death NOUN vq27zk54d78 20 17 in in ADP vq27zk54d78 20 18 ecm ecm NOUN vq27zk54d78 20 19 - - NOUN vq27zk54d78 20 20 detachment detachment NOUN vq27zk54d78 20 21 compared compare VERB vq27zk54d78 20 22 to to ADP vq27zk54d78 20 23 controls control NOUN vq27zk54d78 20 24 . . PUNCT vq27zk54d78 21 1 additionally additionally ADV vq27zk54d78 21 2 , , PUNCT vq27zk54d78 21 3 my my PRON vq27zk54d78 21 4 studies study NOUN vq27zk54d78 21 5 have have AUX vq27zk54d78 21 6 observed observe VERB vq27zk54d78 21 7 that that SCONJ vq27zk54d78 21 8 the the DET vq27zk54d78 21 9 resistance resistance NOUN vq27zk54d78 21 10 to to PART vq27zk54d78 21 11 cytochrome cytochrome NOUN vq27zk54d78 21 12 c c PROPN vq27zk54d78 21 13 in in ADP vq27zk54d78 21 14 ecm ecm PROPN vq27zk54d78 21 15 - - PUNCT vq27zk54d78 21 16 detached detach VERB vq27zk54d78 21 17 ras ras NOUN vq27zk54d78 21 18 cells cell NOUN vq27zk54d78 21 19 is be AUX vq27zk54d78 21 20 not not PART vq27zk54d78 21 21 conferred confer VERB vq27zk54d78 21 22 to to ADP vq27zk54d78 21 23 ecm ecm VERB vq27zk54d78 21 24 - - PUNCT vq27zk54d78 21 25 attached attach VERB vq27zk54d78 21 26 cells cell NOUN vq27zk54d78 21 27 . . PUNCT vq27zk54d78 22 1 upon upon SCONJ vq27zk54d78 22 2 investigation investigation NOUN vq27zk54d78 22 3 of of ADP vq27zk54d78 22 4 apoptosomal apoptosomal ADJ vq27zk54d78 22 5 proteins protein NOUN vq27zk54d78 22 6 , , PUNCT vq27zk54d78 22 7 it it PRON vq27zk54d78 22 8 was be AUX vq27zk54d78 22 9 found find VERB vq27zk54d78 22 10 that that SCONJ vq27zk54d78 22 11 ras ras PROPN vq27zk54d78 22 12 - - ADJ vq27zk54d78 22 13 hyperactivated hyperactivate VERB vq27zk54d78 22 14 cells cell NOUN vq27zk54d78 22 15 in in ADP vq27zk54d78 22 16 ecm ecm NOUN vq27zk54d78 22 17 - - PUNCT vq27zk54d78 22 18 attachment attachment NOUN vq27zk54d78 22 19 exhibit exhibit VERB vq27zk54d78 22 20 an an DET vq27zk54d78 22 21 induction induction NOUN vq27zk54d78 22 22 in in ADP vq27zk54d78 22 23 apoptosomal apoptosomal ADJ vq27zk54d78 22 24 proteins protein NOUN vq27zk54d78 22 25 compared compare VERB vq27zk54d78 22 26 to to ADP vq27zk54d78 22 27 control control NOUN vq27zk54d78 22 28 cells cell NOUN vq27zk54d78 22 29 . . PUNCT vq27zk54d78 23 1 these these DET vq27zk54d78 23 2 data datum NOUN vq27zk54d78 23 3 suggest suggest VERB vq27zk54d78 23 4 that that SCONJ vq27zk54d78 23 5 ras ras PROPN vq27zk54d78 23 6 - - ADJ vq27zk54d78 23 7 hyperactivated hyperactivate VERB vq27zk54d78 23 8 cells cell NOUN vq27zk54d78 23 9 may may AUX vq27zk54d78 23 10 be be AUX vq27zk54d78 23 11 uniquely uniquely ADV vq27zk54d78 23 12 susceptible susceptible ADJ vq27zk54d78 23 13 to to ADP vq27zk54d78 23 14 cytochrome cytochrome NOUN vq27zk54d78 23 15 c c NOUN vq27zk54d78 23 16 mimetic mimetic ADJ vq27zk54d78 23 17 therapies therapy NOUN vq27zk54d78 23 18 in in ADP vq27zk54d78 23 19 ecm ecm NOUN vq27zk54d78 23 20 - - PUNCT vq27zk54d78 23 21 attachment attachment NOUN vq27zk54d78 23 22 . . PUNCT