id	sid	tid	token	lemma	pos
v118rb7241t	1	1	proper	proper	ADJ
v118rb7241t	1	2	maintenance	maintenance	NOUN
v118rb7241t	1	3	of	of	ADP
v118rb7241t	1	4	the	the	DET
v118rb7241t	1	5	cell	cell	NOUN
v118rb7241t	1	6	cycle	cycle	NOUN
v118rb7241t	1	7	relies	rely	VERB
v118rb7241t	1	8	on	on	ADP
v118rb7241t	1	9	regulation	regulation	NOUN
v118rb7241t	1	10	via	via	ADP
v118rb7241t	1	11	pathways	pathway	NOUN
v118rb7241t	1	12	of	of	ADP
v118rb7241t	1	13	signaling	signal	VERB
v118rb7241t	1	14	proteins	protein	NOUN
v118rb7241t	1	15	.	.	PUNCT
v118rb7241t	2	1	the	the	DET
v118rb7241t	2	2	function	function	NOUN
v118rb7241t	2	3	of	of	ADP
v118rb7241t	2	4	these	these	DET
v118rb7241t	2	5	cell	cell	NOUN
v118rb7241t	2	6	signaling	signal	VERB
v118rb7241t	2	7	proteins	protein	NOUN
v118rb7241t	2	8	is	be	AUX
v118rb7241t	2	9	often	often	ADV
v118rb7241t	2	10	modulated	modulate	VERB
v118rb7241t	2	11	by	by	ADP
v118rb7241t	2	12	post	post	ADJ
v118rb7241t	2	13	-	-	ADJ
v118rb7241t	2	14	translational	translational	ADJ
v118rb7241t	2	15	modifications	modification	NOUN
v118rb7241t	2	16	(	(	PUNCT
v118rb7241t	2	17	ptms	ptms	NOUN
v118rb7241t	2	18	)	)	PUNCT
v118rb7241t	2	19	,	,	PUNCT
v118rb7241t	2	20	which	which	PRON
v118rb7241t	2	21	install	install	VERB
v118rb7241t	2	22	new	new	ADJ
v118rb7241t	2	23	functional	functional	ADJ
v118rb7241t	2	24	groups	group	NOUN
v118rb7241t	2	25	on	on	ADP
v118rb7241t	2	26	target	target	NOUN
v118rb7241t	2	27	amino	amino	NOUN
v118rb7241t	2	28	acid	acid	NOUN
v118rb7241t	2	29	residues	residue	NOUN
v118rb7241t	2	30	.	.	PUNCT
v118rb7241t	3	1	these	these	DET
v118rb7241t	3	2	modifications	modification	NOUN
v118rb7241t	3	3	can	can	AUX
v118rb7241t	3	4	affect	affect	VERB
v118rb7241t	3	5	the	the	DET
v118rb7241t	3	6	ensemble	ensemble	NOUN
v118rb7241t	3	7	of	of	ADP
v118rb7241t	3	8	conformations	conformation	NOUN
v118rb7241t	3	9	a	a	DET
v118rb7241t	3	10	protein	protein	NOUN
v118rb7241t	3	11	samples	sample	NOUN
v118rb7241t	3	12	,	,	PUNCT
v118rb7241t	3	13	and	and	CCONJ
v118rb7241t	3	14	thereby	thereby	ADV
v118rb7241t	3	15	its	its	PRON
v118rb7241t	3	16	function	function	NOUN
v118rb7241t	3	17	.	.	PUNCT
v118rb7241t	4	1	an	an	DET
v118rb7241t	4	2	abundant	abundant	ADJ
v118rb7241t	4	3	ptm	ptm	NOUN
v118rb7241t	4	4	in	in	ADP
v118rb7241t	4	5	eukaryotes	eukaryote	NOUN
v118rb7241t	4	6	is	be	AUX
v118rb7241t	4	7	the	the	DET
v118rb7241t	4	8	reversible	reversible	ADJ
v118rb7241t	4	9	phosphorylation	phosphorylation	NOUN
v118rb7241t	4	10	of	of	ADP
v118rb7241t	4	11	serine	serine	NOUN
v118rb7241t	4	12	,	,	PUNCT
v118rb7241t	4	13	threonine	threonine	NOUN
v118rb7241t	4	14	,	,	PUNCT
v118rb7241t	4	15	or	or	CCONJ
v118rb7241t	4	16	tyrosine	tyrosine	NOUN
v118rb7241t	4	17	residues	residue	NOUN
v118rb7241t	4	18	.	.	PUNCT
v118rb7241t	5	1	such	such	ADJ
v118rb7241t	5	2	phosphorylation	phosphorylation	NOUN
v118rb7241t	5	3	can	can	AUX
v118rb7241t	5	4	have	have	VERB
v118rb7241t	5	5	diverse	diverse	ADJ
v118rb7241t	5	6	effects	effect	NOUN
v118rb7241t	5	7	that	that	PRON
v118rb7241t	5	8	include	include	VERB
v118rb7241t	5	9	alteration	alteration	NOUN
v118rb7241t	5	10	of	of	ADP
v118rb7241t	5	11	enzymatic	enzymatic	ADJ
v118rb7241t	5	12	activity	activity	NOUN
v118rb7241t	5	13	,	,	PUNCT
v118rb7241t	5	14	substrate	substrate	NOUN
v118rb7241t	5	15	binding	bind	VERB
v118rb7241t	5	16	affinity	affinity	NOUN
v118rb7241t	5	17	,	,	PUNCT
v118rb7241t	5	18	and/or	and/or	CCONJ
v118rb7241t	5	19	oligomerization	oligomerization	NOUN
v118rb7241t	5	20	states.while	states.while	NOUN
v118rb7241t	5	21	phosphorylation	phosphorylation	NOUN
v118rb7241t	5	22	sites	site	NOUN
v118rb7241t	5	23	and	and	CCONJ
v118rb7241t	5	24	their	their	PRON
v118rb7241t	5	25	biological	biological	ADJ
v118rb7241t	5	26	effects	effect	NOUN
v118rb7241t	5	27	have	have	AUX
v118rb7241t	5	28	been	be	AUX
v118rb7241t	5	29	documented	document	VERB
v118rb7241t	5	30	for	for	ADP
v118rb7241t	5	31	numerous	numerous	ADJ
v118rb7241t	5	32	proteins	protein	NOUN
v118rb7241t	5	33	,	,	PUNCT
v118rb7241t	5	34	their	their	PRON
v118rb7241t	5	35	atomic	atomic	ADJ
v118rb7241t	5	36	mechanisms	mechanism	NOUN
v118rb7241t	5	37	are	be	AUX
v118rb7241t	5	38	not	not	PART
v118rb7241t	5	39	well	well	ADV
v118rb7241t	5	40	understood	understand	VERB
v118rb7241t	5	41	.	.	PUNCT
v118rb7241t	6	1	it	it	PRON
v118rb7241t	6	2	is	be	AUX
v118rb7241t	6	3	known	know	VERB
v118rb7241t	6	4	that	that	SCONJ
v118rb7241t	6	5	the	the	DET
v118rb7241t	6	6	addition	addition	NOUN
v118rb7241t	6	7	of	of	ADP
v118rb7241t	6	8	the	the	DET
v118rb7241t	6	9	phosphate	phosphate	NOUN
v118rb7241t	6	10	moiety	moiety	NOUN
v118rb7241t	6	11	both	both	PRON
v118rb7241t	6	12	increases	increase	VERB
v118rb7241t	6	13	side	side	NOUN
v118rb7241t	6	14	chain	chain	NOUN
v118rb7241t	6	15	steric	steric	ADJ
v118rb7241t	6	16	bulk	bulk	NOUN
v118rb7241t	6	17	and	and	CCONJ
v118rb7241t	6	18	adds	add	VERB
v118rb7241t	6	19	negative	negative	ADJ
v118rb7241t	6	20	charge	charge	NOUN
v118rb7241t	6	21	.	.	PUNCT
v118rb7241t	7	1	however	however	ADV
v118rb7241t	7	2	,	,	PUNCT
v118rb7241t	7	3	there	there	PRON
v118rb7241t	7	4	is	be	VERB
v118rb7241t	7	5	also	also	ADV
v118rb7241t	7	6	growing	grow	VERB
v118rb7241t	7	7	evidence	evidence	NOUN
v118rb7241t	7	8	that	that	SCONJ
v118rb7241t	7	9	the	the	DET
v118rb7241t	7	10	orientations	orientation	NOUN
v118rb7241t	7	11	and	and	CCONJ
v118rb7241t	7	12	motions	motion	NOUN
v118rb7241t	7	13	of	of	ADP
v118rb7241t	7	14	side	side	NOUN
v118rb7241t	7	15	chains	chain	NOUN
v118rb7241t	7	16	promote	promote	VERB
v118rb7241t	7	17	allosteric	allosteric	NOUN
v118rb7241t	7	18	changes	change	NOUN
v118rb7241t	7	19	stimulated	stimulate	VERB
v118rb7241t	7	20	by	by	ADP
v118rb7241t	7	21	phosphorylation	phosphorylation	NOUN
v118rb7241t	7	22	.	.	PUNCT
v118rb7241t	8	1	therefore	therefore	ADV
v118rb7241t	8	2	,	,	PUNCT
v118rb7241t	8	3	it	it	PRON
v118rb7241t	8	4	is	be	AUX
v118rb7241t	8	5	important	important	ADJ
v118rb7241t	8	6	to	to	PART
v118rb7241t	8	7	study	study	VERB
v118rb7241t	8	8	how	how	SCONJ
v118rb7241t	8	9	ptms	ptms	PROPN
v118rb7241t	8	10	affect	affect	VERB
v118rb7241t	8	11	functional	functional	ADJ
v118rb7241t	8	12	dynamics	dynamic	NOUN
v118rb7241t	8	13	.	.	PUNCT
v118rb7241t	9	1	in	in	ADP
v118rb7241t	9	2	many	many	ADJ
v118rb7241t	9	3	cases	case	NOUN
v118rb7241t	9	4	,	,	PUNCT
v118rb7241t	9	5	phosphorylation	phosphorylation	NOUN
v118rb7241t	9	6	sites	site	NOUN
v118rb7241t	9	7	are	be	AUX
v118rb7241t	9	8	also	also	ADV
v118rb7241t	9	9	surrounded	surround	VERB
v118rb7241t	9	10	by	by	ADP
v118rb7241t	9	11	charged	charge	VERB
v118rb7241t	9	12	and	and	CCONJ
v118rb7241t	9	13	polar	polar	ADJ
v118rb7241t	9	14	amino	amino	ADJ
v118rb7241t	9	15	acids	acid	NOUN
v118rb7241t	9	16	,	,	PUNCT
v118rb7241t	9	17	whose	whose	DET
v118rb7241t	9	18	side	side	NOUN
v118rb7241t	9	19	chains	chain	NOUN
v118rb7241t	9	20	would	would	AUX
v118rb7241t	9	21	be	be	AUX
v118rb7241t	9	22	expected	expect	VERB
v118rb7241t	9	23	to	to	PART
v118rb7241t	9	24	be	be	AUX
v118rb7241t	9	25	sensitive	sensitive	ADJ
v118rb7241t	9	26	to	to	ADP
v118rb7241t	9	27	the	the	DET
v118rb7241t	9	28	change	change	NOUN
v118rb7241t	9	29	in	in	ADP
v118rb7241t	9	30	local	local	ADJ
v118rb7241t	9	31	environment.using	environment.use	VERB
v118rb7241t	9	32	solution	solution	NOUN
v118rb7241t	9	33	nmr	nmr	NOUN
v118rb7241t	9	34	techniques	technique	NOUN
v118rb7241t	9	35	on	on	ADP
v118rb7241t	9	36	our	our	PRON
v118rb7241t	9	37	model	model	NOUN
v118rb7241t	9	38	protein	protein	NOUN
v118rb7241t	9	39	human	human	ADJ
v118rb7241t	9	40	pin1	pin1	NOUN
v118rb7241t	9	41	,	,	PUNCT
v118rb7241t	9	42	this	this	DET
v118rb7241t	9	43	thesis	thesis	NOUN
v118rb7241t	9	44	describes	describe	VERB
v118rb7241t	9	45	new	new	ADJ
v118rb7241t	9	46	evidence	evidence	NOUN
v118rb7241t	9	47	of	of	ADP
v118rb7241t	9	48	pre	pre	ADJ
v118rb7241t	9	49	-	-	ADJ
v118rb7241t	9	50	existing	existing	ADJ
v118rb7241t	9	51	networks	network	NOUN
v118rb7241t	9	52	of	of	ADP
v118rb7241t	9	53	electrostatic	electrostatic	ADJ
v118rb7241t	9	54	interactions	interaction	NOUN
v118rb7241t	9	55	that	that	PRON
v118rb7241t	9	56	are	be	AUX
v118rb7241t	9	57	perturbed	perturb	VERB
v118rb7241t	9	58	by	by	ADP
v118rb7241t	9	59	phosphorylation	phosphorylation	NOUN
v118rb7241t	9	60	and	and	CCONJ
v118rb7241t	9	61	mediate	mediate	VERB
v118rb7241t	9	62	long	long	ADJ
v118rb7241t	9	63	-	-	PUNCT
v118rb7241t	9	64	range	range	NOUN
v118rb7241t	9	65	allosteric	allosteric	NOUN
v118rb7241t	9	66	changes	change	NOUN
v118rb7241t	9	67	.	.	PUNCT
v118rb7241t	10	1	this	this	DET
v118rb7241t	10	2	same	same	ADJ
v118rb7241t	10	3	principle	principle	NOUN
v118rb7241t	10	4	appears	appear	VERB
v118rb7241t	10	5	to	to	PART
v118rb7241t	10	6	be	be	AUX
v118rb7241t	10	7	used	use	VERB
v118rb7241t	10	8	in	in	ADP
v118rb7241t	10	9	pin1	pin1	NOUN
v118rb7241t	10	10	to	to	PART
v118rb7241t	10	11	effect	effect	VERB
v118rb7241t	10	12	distinct	distinct	ADJ
v118rb7241t	10	13	functional	functional	ADJ
v118rb7241t	10	14	consequences	consequence	NOUN
v118rb7241t	10	15	.	.	PUNCT
v118rb7241t	11	1	comprehending	comprehend	VERB
v118rb7241t	11	2	how	how	SCONJ
v118rb7241t	11	3	these	these	DET
v118rb7241t	11	4	phosphorylation	phosphorylation	NOUN
v118rb7241t	11	5	events	event	NOUN
v118rb7241t	11	6	affect	affect	VERB
v118rb7241t	11	7	pin1	pin1	NOUN
v118rb7241t	11	8	function	function	NOUN
v118rb7241t	11	9	will	will	AUX
v118rb7241t	11	10	hopefully	hopefully	ADV
v118rb7241t	11	11	lead	lead	VERB
v118rb7241t	11	12	to	to	ADP
v118rb7241t	11	13	the	the	DET
v118rb7241t	11	14	ability	ability	NOUN
v118rb7241t	11	15	to	to	PART
v118rb7241t	11	16	better	well	ADV
v118rb7241t	11	17	predict	predict	VERB
v118rb7241t	11	18	the	the	DET
v118rb7241t	11	19	outcomes	outcome	NOUN
v118rb7241t	11	20	of	of	ADP
v118rb7241t	11	21	these	these	DET
v118rb7241t	11	22	ptms	ptms	NOUN
v118rb7241t	11	23	in	in	ADP
v118rb7241t	11	24	other	other	ADJ
v118rb7241t	11	25	cell	cell	NOUN
v118rb7241t	11	26	-	-	PUNCT
v118rb7241t	11	27	signaling	signal	VERB
v118rb7241t	11	28	proteins	protein	NOUN
v118rb7241t	11	29	.	.	PUNCT
v118rb7241t	12	1	enhanced	enhance	VERB
v118rb7241t	12	2	understanding	understanding	NOUN
v118rb7241t	12	3	of	of	ADP
v118rb7241t	12	4	the	the	DET
v118rb7241t	12	5	atomic	atomic	ADJ
v118rb7241t	12	6	-	-	PUNCT
v118rb7241t	12	7	level	level	NOUN
v118rb7241t	12	8	response	response	NOUN
v118rb7241t	12	9	mechanisms	mechanism	NOUN
v118rb7241t	12	10	to	to	ADP
v118rb7241t	12	11	post	post	ADJ
v118rb7241t	12	12	-	-	ADJ
v118rb7241t	12	13	translational	translational	ADJ
v118rb7241t	12	14	phosphorylation	phosphorylation	NOUN
v118rb7241t	12	15	may	may	AUX
v118rb7241t	12	16	lead	lead	VERB
v118rb7241t	12	17	to	to	ADP
v118rb7241t	12	18	principles	principle	NOUN
v118rb7241t	12	19	important	important	ADJ
v118rb7241t	12	20	in	in	ADP
v118rb7241t	12	21	emulative	emulative	ADJ
v118rb7241t	12	22	drug	drug	NOUN
v118rb7241t	12	23	design	design	NOUN
v118rb7241t	12	24	.	.	PUNCT