id sid tid token lemma pos v118rb71f7d 1 1 the the DET v118rb71f7d 1 2 ability ability NOUN v118rb71f7d 1 3 of of ADP v118rb71f7d 1 4 cancer cancer NOUN v118rb71f7d 1 5 cells cell NOUN v118rb71f7d 1 6 to to PART v118rb71f7d 1 7 detach detach VERB v118rb71f7d 1 8 from from ADP v118rb71f7d 1 9 their their PRON v118rb71f7d 1 10 tumor tumor NOUN v118rb71f7d 1 11 of of ADP v118rb71f7d 1 12 origin origin NOUN v118rb71f7d 1 13 and and CCONJ v118rb71f7d 1 14 ? ? PUNCT v118rb71f7d 1 15 invade invade VERB v118rb71f7d 1 16 ? ? PUNCT v118rb71f7d 2 1 into into ADP v118rb71f7d 2 2 surrounding surround VERB v118rb71f7d 2 3 tissue tissue NOUN v118rb71f7d 2 4 marks mark VERB v118rb71f7d 2 5 a a DET v118rb71f7d 2 6 turning turning NOUN v118rb71f7d 2 7 point point NOUN v118rb71f7d 2 8 in in ADP v118rb71f7d 2 9 cancer cancer NOUN v118rb71f7d 2 10 progression progression NOUN v118rb71f7d 2 11 . . PUNCT v118rb71f7d 3 1 invadopodia invadopodia NOUN v118rb71f7d 3 2 and and CCONJ v118rb71f7d 3 3 microvesicles microvesicle NOUN v118rb71f7d 3 4 are be AUX v118rb71f7d 3 5 cytoskeleton cytoskeleton NOUN v118rb71f7d 3 6 - - PUNCT v118rb71f7d 3 7 rich rich ADJ v118rb71f7d 3 8 membrane membrane NOUN v118rb71f7d 3 9 structures structure NOUN v118rb71f7d 3 10 via via ADP v118rb71f7d 3 11 which which PRON v118rb71f7d 3 12 cells cell NOUN v118rb71f7d 3 13 can can AUX v118rb71f7d 3 14 proteolyze proteolyze VERB v118rb71f7d 3 15 the the DET v118rb71f7d 3 16 extracellular extracellular ADJ v118rb71f7d 3 17 environment environment NOUN v118rb71f7d 3 18 to to PART v118rb71f7d 3 19 facilitate facilitate VERB v118rb71f7d 3 20 invasion invasion NOUN v118rb71f7d 3 21 , , PUNCT v118rb71f7d 3 22 and and CCONJ v118rb71f7d 3 23 their their PRON v118rb71f7d 3 24 regulation regulation NOUN v118rb71f7d 3 25 is be AUX v118rb71f7d 3 26 a a DET v118rb71f7d 3 27 focus focus NOUN v118rb71f7d 3 28 of of ADP v118rb71f7d 3 29 this this DET v118rb71f7d 3 30 dissertation dissertation NOUN v118rb71f7d 3 31 . . PUNCT v118rb71f7d 4 1 robust robust ADJ v118rb71f7d 4 2 motility motility NOUN v118rb71f7d 4 3 is be AUX v118rb71f7d 4 4 also also ADV v118rb71f7d 4 5 integral integral ADJ v118rb71f7d 4 6 for for ADP v118rb71f7d 4 7 tumor tumor NOUN v118rb71f7d 4 8 cell cell NOUN v118rb71f7d 4 9 invasion invasion NOUN v118rb71f7d 4 10 , , PUNCT v118rb71f7d 4 11 and and CCONJ v118rb71f7d 4 12 we we PRON v118rb71f7d 4 13 describe describe VERB v118rb71f7d 4 14 how how SCONJ v118rb71f7d 4 15 signaling signal VERB v118rb71f7d 4 16 of of ADP v118rb71f7d 4 17 the the DET v118rb71f7d 4 18 small small ADJ v118rb71f7d 4 19 gtpase gtpase NOUN v118rb71f7d 4 20 arf6 arf6 PROPN v118rb71f7d 4 21 coordinates coordinate VERB v118rb71f7d 4 22 these these DET v118rb71f7d 4 23 activities activity NOUN v118rb71f7d 4 24 . . PUNCT v118rb71f7d 5 1 this this DET v118rb71f7d 5 2 dissertation dissertation NOUN v118rb71f7d 5 3 describes describe VERB v118rb71f7d 5 4 how how SCONJ v118rb71f7d 5 5 alterations alteration NOUN v118rb71f7d 5 6 in in ADP v118rb71f7d 5 7 extracellular extracellular ADJ v118rb71f7d 5 8 matrix matrix NOUN v118rb71f7d 5 9 compliance compliance NOUN v118rb71f7d 5 10 guide guide VERB v118rb71f7d 5 11 the the DET v118rb71f7d 5 12 formation formation NOUN v118rb71f7d 5 13 of of ADP v118rb71f7d 5 14 microvesicles microvesicle NOUN v118rb71f7d 5 15 and and CCONJ v118rb71f7d 5 16 invadopodia invadopodia NOUN v118rb71f7d 5 17 to to PART v118rb71f7d 5 18 facilitate facilitate VERB v118rb71f7d 5 19 matrix matrix NOUN v118rb71f7d 5 20 proteolysis proteolysis NOUN v118rb71f7d 5 21 . . PUNCT v118rb71f7d 6 1 the the DET v118rb71f7d 6 2 data datum NOUN v118rb71f7d 6 3 presented present VERB v118rb71f7d 6 4 here here ADV v118rb71f7d 6 5 indicates indicate VERB v118rb71f7d 6 6 that that SCONJ v118rb71f7d 6 7 formation formation NOUN v118rb71f7d 6 8 of of ADP v118rb71f7d 6 9 these these DET v118rb71f7d 6 10 structures structure NOUN v118rb71f7d 6 11 is be AUX v118rb71f7d 6 12 mutually mutually ADV v118rb71f7d 6 13 exclusive exclusive ADJ v118rb71f7d 6 14 , , PUNCT v118rb71f7d 6 15 regulated regulate VERB v118rb71f7d 6 16 by by ADP v118rb71f7d 6 17 antagonistic antagonistic ADJ v118rb71f7d 6 18 signaling signaling NOUN v118rb71f7d 6 19 between between ADP v118rb71f7d 6 20 the the DET v118rb71f7d 6 21 small small ADJ v118rb71f7d 6 22 gtpases gtpase NOUN v118rb71f7d 6 23 rac1 rac1 PROPN v118rb71f7d 6 24 and and CCONJ v118rb71f7d 6 25 rhoa rhoa PROPN v118rb71f7d 6 26 . . PUNCT v118rb71f7d 7 1 in in ADP v118rb71f7d 7 2 addition addition NOUN v118rb71f7d 7 3 , , PUNCT v118rb71f7d 7 4 we we PRON v118rb71f7d 7 5 have have AUX v118rb71f7d 7 6 described describe VERB v118rb71f7d 7 7 how how SCONJ v118rb71f7d 7 8 rho rho NOUN v118rb71f7d 7 9 signaling signaling NOUN v118rb71f7d 7 10 regulates regulate VERB v118rb71f7d 7 11 myosin myosin NOUN v118rb71f7d 7 12 light light ADJ v118rb71f7d 7 13 chain chain NOUN v118rb71f7d 7 14 phosphatase phosphatase NOUN v118rb71f7d 7 15 during during ADP v118rb71f7d 7 16 myosin myosin PROPN v118rb71f7d 7 17 contractility contractility NOUN v118rb71f7d 7 18 , , PUNCT v118rb71f7d 7 19 required require VERB v118rb71f7d 7 20 for for ADP v118rb71f7d 7 21 release release NOUN v118rb71f7d 7 22 of of ADP v118rb71f7d 7 23 microvesicles microvesicle NOUN v118rb71f7d 7 24 from from ADP v118rb71f7d 7 25 the the DET v118rb71f7d 7 26 tumor tumor NOUN v118rb71f7d 7 27 cell cell NOUN v118rb71f7d 7 28 surface surface NOUN v118rb71f7d 7 29 . . PUNCT v118rb71f7d 8 1 critical critical ADJ v118rb71f7d 8 2 to to ADP v118rb71f7d 8 3 arf6 arf6 PROPN v118rb71f7d 8 4 - - PUNCT v118rb71f7d 8 5 mediated mediate VERB v118rb71f7d 8 6 regulation regulation NOUN v118rb71f7d 8 7 of of ADP v118rb71f7d 8 8 tumor tumor NOUN v118rb71f7d 8 9 cell cell NOUN v118rb71f7d 8 10 invasion invasion NOUN v118rb71f7d 8 11 are be AUX v118rb71f7d 8 12 the the DET v118rb71f7d 8 13 activities activity NOUN v118rb71f7d 8 14 of of ADP v118rb71f7d 8 15 the the DET v118rb71f7d 8 16 gtpase gtpase NOUN v118rb71f7d 8 17 activating activate VERB v118rb71f7d 8 18 proteins protein NOUN v118rb71f7d 8 19 ( ( PUNCT v118rb71f7d 8 20 gaps gap NOUN v118rb71f7d 8 21 ) ) PUNCT v118rb71f7d 8 22 and and CCONJ v118rb71f7d 8 23 exchange exchange NOUN v118rb71f7d 8 24 factors factor NOUN v118rb71f7d 8 25 ( ( PUNCT v118rb71f7d 8 26 gefs gef NOUN v118rb71f7d 8 27 ) ) PUNCT v118rb71f7d 8 28 that that PRON v118rb71f7d 8 29 control control VERB v118rb71f7d 8 30 its its PRON v118rb71f7d 8 31 nucleotide nucleotide NOUN v118rb71f7d 8 32 status status NOUN v118rb71f7d 8 33 . . PUNCT v118rb71f7d 9 1 activation activation NOUN v118rb71f7d 9 2 of of ADP v118rb71f7d 9 3 arf6 arf6 PROPN v118rb71f7d 9 4 downstream downstream ADJ v118rb71f7d 9 5 of of ADP v118rb71f7d 9 6 wnt5a wnt5a PROPN v118rb71f7d 9 7 stimulates stimulate VERB v118rb71f7d 9 8 invasive invasive ADJ v118rb71f7d 9 9 ability ability NOUN v118rb71f7d 9 10 via via ADP v118rb71f7d 9 11 the the DET v118rb71f7d 9 12 wnt/β-catenin wnt/β-catenin PROPN v118rb71f7d 9 13 canonical canonical ADJ v118rb71f7d 9 14 pathway pathway NOUN v118rb71f7d 9 15 , , PUNCT v118rb71f7d 9 16 and and CCONJ v118rb71f7d 9 17 is be AUX v118rb71f7d 9 18 opposed oppose VERB v118rb71f7d 9 19 by by ADP v118rb71f7d 9 20 signaling signal VERB v118rb71f7d 9 21 through through ADP v118rb71f7d 9 22 slit2 slit2 PROPN v118rb71f7d 9 23 - - PUNCT v118rb71f7d 9 24 robo1 robo1 PROPN v118rb71f7d 9 25 , , PUNCT v118rb71f7d 9 26 which which PRON v118rb71f7d 9 27 stimulates stimulate VERB v118rb71f7d 9 28 arf6 arf6 PROPN v118rb71f7d 9 29 gaps gap NOUN v118rb71f7d 9 30 . . PUNCT v118rb71f7d 10 1 during during ADP v118rb71f7d 10 2 epithelial epithelial ADJ v118rb71f7d 10 3 cell cell NOUN v118rb71f7d 10 4 migration migration NOUN v118rb71f7d 10 5 , , PUNCT v118rb71f7d 10 6 the the DET v118rb71f7d 10 7 actin actin NOUN v118rb71f7d 10 8 - - PUNCT v118rb71f7d 10 9 binding bind VERB v118rb71f7d 10 10 protein protein NOUN v118rb71f7d 10 11 cd2ap cd2ap NOUN v118rb71f7d 10 12 is be AUX v118rb71f7d 10 13 capable capable ADJ v118rb71f7d 10 14 of of ADP v118rb71f7d 10 15 downregulating downregulate VERB v118rb71f7d 10 16 arf6 arf6 PROPN v118rb71f7d 10 17 activity activity NOUN v118rb71f7d 10 18 by by ADP v118rb71f7d 10 19 recruiting recruit VERB v118rb71f7d 10 20 and and CCONJ v118rb71f7d 10 21 stabilizing stabilize VERB v118rb71f7d 10 22 the the DET v118rb71f7d 10 23 gaps gap NOUN v118rb71f7d 10 24 arfgap3 arfgap3 ADV v118rb71f7d 11 1 and and CCONJ v118rb71f7d 11 2 asap asap PROPN v118rb71f7d 11 3 at at ADP v118rb71f7d 11 4 the the DET v118rb71f7d 11 5 cell cell NOUN v118rb71f7d 11 6 surface surface NOUN v118rb71f7d 11 7 . . PUNCT v118rb71f7d 12 1 to to PART v118rb71f7d 12 2 further far ADV v118rb71f7d 12 3 delineate delineate VERB v118rb71f7d 12 4 the the DET v118rb71f7d 12 5 contribution contribution NOUN v118rb71f7d 12 6 of of ADP v118rb71f7d 12 7 arf6 arf6 PROPN v118rb71f7d 12 8 to to ADP v118rb71f7d 12 9 cell cell NOUN v118rb71f7d 12 10 invasion invasion NOUN v118rb71f7d 12 11 , , PUNCT v118rb71f7d 12 12 we we PRON v118rb71f7d 12 13 developed develop VERB v118rb71f7d 12 14 new new ADJ v118rb71f7d 12 15 reagents reagent NOUN v118rb71f7d 12 16 that that PRON v118rb71f7d 12 17 target target VERB v118rb71f7d 12 18 its its PRON v118rb71f7d 12 19 downregulation downregulation NOUN v118rb71f7d 12 20 , , PUNCT v118rb71f7d 12 21 including include VERB v118rb71f7d 12 22 a a DET v118rb71f7d 12 23 lentiviral lentiviral ADJ v118rb71f7d 12 24 vector vector NOUN v118rb71f7d 12 25 for for ADP v118rb71f7d 12 26 arf6 arf6 PROPN v118rb71f7d 12 27 silencing silencing NOUN v118rb71f7d 12 28 . . PUNCT v118rb71f7d 13 1 this this DET v118rb71f7d 13 2 vector vector NOUN v118rb71f7d 13 3 has have AUX v118rb71f7d 13 4 demonstrated demonstrate VERB v118rb71f7d 13 5 very very ADV v118rb71f7d 13 6 effective effective ADJ v118rb71f7d 13 7 knockdown knockdown NOUN v118rb71f7d 13 8 of of ADP v118rb71f7d 13 9 arf6 arf6 PROPN v118rb71f7d 13 10 levels level NOUN v118rb71f7d 13 11 , , PUNCT v118rb71f7d 13 12 however however ADV v118rb71f7d 13 13 , , PUNCT v118rb71f7d 13 14 additional additional ADJ v118rb71f7d 13 15 work work NOUN v118rb71f7d 13 16 will will AUX v118rb71f7d 13 17 be be AUX v118rb71f7d 13 18 necessary necessary ADJ v118rb71f7d 13 19 to to PART v118rb71f7d 13 20 address address VERB v118rb71f7d 13 21 off off ADP v118rb71f7d 13 22 - - PUNCT v118rb71f7d 13 23 target target NOUN v118rb71f7d 13 24 effects effect NOUN v118rb71f7d 13 25 of of ADP v118rb71f7d 13 26 the the DET v118rb71f7d 13 27 virus virus NOUN v118rb71f7d 13 28 before before SCONJ v118rb71f7d 13 29 it it PRON v118rb71f7d 13 30 can can AUX v118rb71f7d 13 31 be be AUX v118rb71f7d 13 32 utilized utilize VERB v118rb71f7d 13 33 for for ADP v118rb71f7d 13 34 studies study NOUN v118rb71f7d 13 35 of of ADP v118rb71f7d 13 36 tumor tumor NOUN v118rb71f7d 13 37 cell cell NOUN v118rb71f7d 13 38 invasion invasion NOUN v118rb71f7d 13 39 . . PUNCT v118rb71f7d 14 1 we we PRON v118rb71f7d 14 2 also also ADV v118rb71f7d 14 3 tested test VERB v118rb71f7d 14 4 the the DET v118rb71f7d 14 5 hypothesis hypothesis NOUN v118rb71f7d 14 6 that that SCONJ v118rb71f7d 14 7 src src NOUN v118rb71f7d 14 8 - - PUNCT v118rb71f7d 14 9 mediated mediate VERB v118rb71f7d 14 10 phosphorylation phosphorylation NOUN v118rb71f7d 14 11 of of ADP v118rb71f7d 14 12 the the DET v118rb71f7d 14 13 arf6 arf6 PROPN v118rb71f7d 14 14 gap gap NOUN v118rb71f7d 14 15 acap2 acap2 PROPN v118rb71f7d 14 16 will will AUX v118rb71f7d 14 17 result result VERB v118rb71f7d 14 18 in in ADP v118rb71f7d 14 19 increased increase VERB v118rb71f7d 14 20 arf6 arf6 PROPN v118rb71f7d 14 21 - - PUNCT v118rb71f7d 14 22 gtp gtp PROPN v118rb71f7d 14 23 levels level NOUN v118rb71f7d 14 24 during during ADP v118rb71f7d 14 25 tumor tumor NOUN v118rb71f7d 14 26 cell cell NOUN v118rb71f7d 14 27 invasion invasion NOUN v118rb71f7d 14 28 , , PUNCT v118rb71f7d 14 29 and and CCONJ v118rb71f7d 14 30 have have AUX v118rb71f7d 14 31 created create VERB v118rb71f7d 14 32 plasmids plasmid NOUN v118rb71f7d 14 33 for for ADP v118rb71f7d 14 34 the the DET v118rb71f7d 14 35 expression expression NOUN v118rb71f7d 14 36 of of ADP v118rb71f7d 14 37 acap2 acap2 PROPN v118rb71f7d 14 38 phosphorylation phosphorylation NOUN v118rb71f7d 14 39 mutants mutant NOUN v118rb71f7d 14 40 for for ADP v118rb71f7d 14 41 these these DET v118rb71f7d 14 42 studies study NOUN v118rb71f7d 14 43 . . PUNCT v118rb71f7d 15 1 finally finally ADV v118rb71f7d 15 2 , , PUNCT v118rb71f7d 15 3 we we PRON v118rb71f7d 15 4 describe describe VERB v118rb71f7d 15 5 the the DET v118rb71f7d 15 6 use use NOUN v118rb71f7d 15 7 of of ADP v118rb71f7d 15 8 a a DET v118rb71f7d 15 9 tumor tumor NOUN v118rb71f7d 15 10 cell cell NOUN v118rb71f7d 15 11 spheroid spheroid NOUN v118rb71f7d 15 12 assay assay VERB v118rb71f7d 15 13 for for ADP v118rb71f7d 15 14 assessing assess VERB v118rb71f7d 15 15 invasive invasive ADJ v118rb71f7d 15 16 behavior behavior NOUN v118rb71f7d 15 17 , , PUNCT v118rb71f7d 15 18 which which PRON v118rb71f7d 15 19 sheds shed VERB v118rb71f7d 15 20 light light NOUN v118rb71f7d 15 21 on on ADP v118rb71f7d 15 22 the the DET v118rb71f7d 15 23 negative negative ADJ v118rb71f7d 15 24 impact impact NOUN v118rb71f7d 15 25 that that PRON v118rb71f7d 15 26 constitutive constitutive ADJ v118rb71f7d 15 27 arf6 arf6 PROPN v118rb71f7d 15 28 activation activation NOUN v118rb71f7d 15 29 has have VERB v118rb71f7d 15 30 on on ADP v118rb71f7d 15 31 the the DET v118rb71f7d 15 32 development development NOUN v118rb71f7d 15 33 of of ADP v118rb71f7d 15 34 metastatic metastatic ADJ v118rb71f7d 15 35 lesions lesion NOUN v118rb71f7d 15 36 . . PUNCT