id sid tid token lemma pos tx31qf88477 1 1 breast breast NOUN tx31qf88477 1 2 cancer cancer NOUN tx31qf88477 1 3 is be AUX tx31qf88477 1 4 the the DET tx31qf88477 1 5 most most ADV tx31qf88477 1 6 frequently frequently ADV tx31qf88477 1 7 diagnosed diagnose VERB tx31qf88477 1 8 cancer cancer NOUN tx31qf88477 1 9 in in ADP tx31qf88477 1 10 women woman NOUN tx31qf88477 1 11 and and CCONJ tx31qf88477 1 12 is be AUX tx31qf88477 1 13 responsible responsible ADJ tx31qf88477 1 14 for for ADP tx31qf88477 1 15 the the DET tx31qf88477 1 16 largest large ADJ tx31qf88477 1 17 number number NOUN tx31qf88477 1 18 of of ADP tx31qf88477 1 19 cancer cancer NOUN tx31qf88477 1 20 related relate VERB tx31qf88477 1 21 deaths death NOUN tx31qf88477 1 22 in in ADP tx31qf88477 1 23 women woman NOUN tx31qf88477 1 24 across across ADP tx31qf88477 1 25 the the DET tx31qf88477 1 26 globe globe NOUN tx31qf88477 1 27 . . PUNCT tx31qf88477 2 1 basic basic ADJ tx31qf88477 2 2 research research NOUN tx31qf88477 2 3 into into ADP tx31qf88477 2 4 the the DET tx31qf88477 2 5 roles role NOUN tx31qf88477 2 6 of of ADP tx31qf88477 2 7 cancer cancer NOUN tx31qf88477 2 8 - - PUNCT tx31qf88477 2 9 related relate VERB tx31qf88477 2 10 genes gene NOUN tx31qf88477 2 11 in in ADP tx31qf88477 2 12 normal normal ADJ tx31qf88477 2 13 development development NOUN tx31qf88477 2 14 is be AUX tx31qf88477 2 15 crucial crucial ADJ tx31qf88477 2 16 to to ADP tx31qf88477 2 17 understanding understand VERB tx31qf88477 2 18 their their PRON tx31qf88477 2 19 roles role NOUN tx31qf88477 2 20 in in ADP tx31qf88477 2 21 cancer cancer NOUN tx31qf88477 2 22 and and CCONJ tx31qf88477 2 23 will will AUX tx31qf88477 2 24 aid aid VERB tx31qf88477 2 25 in in ADP tx31qf88477 2 26 developing develop VERB tx31qf88477 2 27 new new ADJ tx31qf88477 2 28 targeted target VERB tx31qf88477 2 29 therapies therapy NOUN tx31qf88477 2 30 . . PUNCT tx31qf88477 3 1 altered altered ADJ tx31qf88477 3 2 expression expression NOUN tx31qf88477 3 3 of of ADP tx31qf88477 3 4 the the DET tx31qf88477 3 5 rho rho NOUN tx31qf88477 3 6 gtpases gtpase NOUN tx31qf88477 3 7 and and CCONJ tx31qf88477 3 8 their their PRON tx31qf88477 3 9 regulators regulator NOUN tx31qf88477 3 10 is be AUX tx31qf88477 3 11 associated associate VERB tx31qf88477 3 12 with with ADP tx31qf88477 3 13 breast breast NOUN tx31qf88477 3 14 cancer cancer NOUN tx31qf88477 3 15 . . PUNCT tx31qf88477 4 1 the the DET tx31qf88477 4 2 focus focus NOUN tx31qf88477 4 3 of of ADP tx31qf88477 4 4 my my PRON tx31qf88477 4 5 project project NOUN tx31qf88477 4 6 was be AUX tx31qf88477 4 7 to to PART tx31qf88477 4 8 investigate investigate VERB tx31qf88477 4 9 the the DET tx31qf88477 4 10 role role NOUN tx31qf88477 4 11 of of ADP tx31qf88477 4 12 the the DET tx31qf88477 4 13 rho rho PROPN tx31qf88477 4 14 gtpase gtpase NOUN tx31qf88477 4 15 cdc42 cdc42 NOUN tx31qf88477 4 16 during during ADP tx31qf88477 4 17 normal normal ADJ tx31qf88477 4 18 mammary mammary ADJ tx31qf88477 4 19 gland gland NOUN tx31qf88477 4 20 ( ( PUNCT tx31qf88477 4 21 mg mg NOUN tx31qf88477 4 22 ) ) PUNCT tx31qf88477 4 23 development development NOUN tx31qf88477 4 24 to to PART tx31qf88477 4 25 define define VERB tx31qf88477 4 26 the the DET tx31qf88477 4 27 key key ADJ tx31qf88477 4 28 cellular cellular ADJ tx31qf88477 4 29 processes process NOUN tx31qf88477 4 30 regulated regulate VERB tx31qf88477 4 31 by by ADP tx31qf88477 4 32 cdc42 cdc42 SPACE tx31qf88477 4 33 , , PUNCT tx31qf88477 4 34 as as SCONJ tx31qf88477 4 35 deregulation deregulation NOUN tx31qf88477 4 36 of of ADP tx31qf88477 4 37 these these DET tx31qf88477 4 38 processes process NOUN tx31qf88477 4 39 may may AUX tx31qf88477 4 40 occur occur VERB tx31qf88477 4 41 when when SCONJ tx31qf88477 4 42 the the DET tx31qf88477 4 43 expression expression NOUN tx31qf88477 4 44 and and CCONJ tx31qf88477 4 45 activity activity NOUN tx31qf88477 4 46 of of ADP tx31qf88477 4 47 cdc42 cdc42 NOUN tx31qf88477 4 48 is be AUX tx31qf88477 4 49 elevated elevate VERB tx31qf88477 4 50 during during ADP tx31qf88477 4 51 the the DET tx31qf88477 4 52 development development NOUN tx31qf88477 4 53 and and CCONJ tx31qf88477 4 54 progression progression NOUN tx31qf88477 4 55 of of ADP tx31qf88477 4 56 breast breast NOUN tx31qf88477 4 57 cancer cancer NOUN tx31qf88477 4 58 . . PUNCT tx31qf88477 5 1 using use VERB tx31qf88477 5 2 novel novel ADJ tx31qf88477 5 3 conditional conditional ADJ tx31qf88477 5 4 knockout knockout NOUN tx31qf88477 5 5 ( ( PUNCT tx31qf88477 5 6 ko ko PROPN tx31qf88477 5 7 ) ) PUNCT tx31qf88477 5 8 and and CCONJ tx31qf88477 5 9 overexpression overexpression NOUN tx31qf88477 5 10 ( ( PUNCT tx31qf88477 5 11 oe oe PROPN tx31qf88477 5 12 ) ) PUNCT tx31qf88477 5 13 mouse mouse PROPN tx31qf88477 5 14 mg mg PROPN tx31qf88477 5 15 models model NOUN tx31qf88477 5 16 , , PUNCT tx31qf88477 5 17 my my PRON tx31qf88477 5 18 studies study NOUN tx31qf88477 5 19 revealed reveal VERB tx31qf88477 5 20 for for ADP tx31qf88477 5 21 the the DET tx31qf88477 5 22 first first ADJ tx31qf88477 5 23 time time NOUN tx31qf88477 5 24 critical critical ADJ tx31qf88477 5 25 roles role NOUN tx31qf88477 5 26 for for ADP tx31qf88477 5 27 cdc42 cdc42 NOUN tx31qf88477 5 28 in in ADP tx31qf88477 5 29 mammary mammary ADJ tx31qf88477 5 30 epithelial epithelial ADJ tx31qf88477 5 31 proliferation proliferation NOUN tx31qf88477 5 32 , , PUNCT tx31qf88477 5 33 migration migration NOUN tx31qf88477 5 34 , , PUNCT tx31qf88477 5 35 adhesion adhesion NOUN tx31qf88477 5 36 , , PUNCT tx31qf88477 5 37 stromal stromal ADJ tx31qf88477 5 38 interactions interaction NOUN tx31qf88477 5 39 , , PUNCT tx31qf88477 5 40 and and CCONJ tx31qf88477 5 41 morphogenesis morphogenesis NOUN tx31qf88477 5 42 and and CCONJ tx31qf88477 5 43 support support VERB tx31qf88477 5 44 a a DET tx31qf88477 5 45 working work VERB tx31qf88477 5 46 hypothesis hypothesis NOUN tx31qf88477 5 47 for for ADP tx31qf88477 5 48 how how SCONJ tx31qf88477 5 49 cdc42 cdc42 NOUN tx31qf88477 5 50 is be AUX tx31qf88477 5 51 functioning function VERB tx31qf88477 5 52 during during ADP tx31qf88477 5 53 mg mg PROPN tx31qf88477 5 54 development development NOUN tx31qf88477 5 55 . . PUNCT tx31qf88477 6 1 in in ADP tx31qf88477 6 2 the the DET tx31qf88477 6 3 context context NOUN tx31qf88477 6 4 of of ADP tx31qf88477 6 5 normal normal ADJ tx31qf88477 6 6 levels level NOUN tx31qf88477 6 7 of of ADP tx31qf88477 6 8 cdc42 cdc42 ADJ tx31qf88477 6 9 expression expression NOUN tx31qf88477 6 10 , , PUNCT tx31qf88477 6 11 cdc42 cdc42 NOUN tx31qf88477 6 12 participates participate NOUN tx31qf88477 6 13 in in ADP tx31qf88477 6 14 the the DET tx31qf88477 6 15 par par NOUN tx31qf88477 6 16 / / SYM tx31qf88477 6 17 pkc pkc NOUN tx31qf88477 6 18 zeta zeta NOUN tx31qf88477 6 19 polarity polarity NOUN tx31qf88477 6 20 complex complex NOUN tx31qf88477 6 21 to to PART tx31qf88477 6 22 form form VERB tx31qf88477 6 23 tight tight ADJ tx31qf88477 6 24 junctions junction NOUN tx31qf88477 6 25 , , PUNCT tx31qf88477 6 26 establish establish VERB tx31qf88477 6 27 epithelial epithelial ADJ tx31qf88477 6 28 polarity polarity NOUN tx31qf88477 6 29 , , PUNCT tx31qf88477 6 30 and and CCONJ tx31qf88477 6 31 promote promote VERB tx31qf88477 6 32 normal normal ADJ tx31qf88477 6 33 proliferation proliferation NOUN tx31qf88477 6 34 and and CCONJ tx31qf88477 6 35 morphogenesis morphogenesis NOUN tx31qf88477 6 36 of of ADP tx31qf88477 6 37 the the DET tx31qf88477 6 38 mammary mammary ADJ tx31qf88477 6 39 ductal ductal NOUN tx31qf88477 6 40 tree tree NOUN tx31qf88477 6 41 . . PUNCT tx31qf88477 7 1 in in ADP tx31qf88477 7 2 the the DET tx31qf88477 7 3 absence absence NOUN tx31qf88477 7 4 of of ADP tx31qf88477 7 5 cdc42 cdc42 SPACE tx31qf88477 7 6 , , PUNCT tx31qf88477 7 7 the the DET tx31qf88477 7 8 complete complete ADJ tx31qf88477 7 9 polarity polarity NOUN tx31qf88477 7 10 complex complex NOUN tx31qf88477 7 11 can can AUX tx31qf88477 7 12 not not PART tx31qf88477 7 13 form form VERB tx31qf88477 7 14 , , PUNCT tx31qf88477 7 15 thus thus ADV tx31qf88477 7 16 tight tight ADJ tx31qf88477 7 17 junctions junction NOUN tx31qf88477 7 18 and and CCONJ tx31qf88477 7 19 polarity polarity NOUN tx31qf88477 7 20 can can AUX tx31qf88477 7 21 not not PART tx31qf88477 7 22 be be AUX tx31qf88477 7 23 established establish VERB tx31qf88477 7 24 . . PUNCT tx31qf88477 8 1 without without ADP tx31qf88477 8 2 these these DET tx31qf88477 8 3 important important ADJ tx31qf88477 8 4 initial initial ADJ tx31qf88477 8 5 steps step NOUN tx31qf88477 8 6 the the DET tx31qf88477 8 7 mammary mammary ADJ tx31qf88477 8 8 epithelial epithelial ADJ tx31qf88477 8 9 cells cell NOUN tx31qf88477 8 10 ( ( PUNCT tx31qf88477 8 11 mecs mecs PROPN tx31qf88477 8 12 ) ) PUNCT tx31qf88477 8 13 can can AUX tx31qf88477 8 14 not not PART tx31qf88477 8 15 properly properly ADV tx31qf88477 8 16 organize organize VERB tx31qf88477 8 17 and and CCONJ tx31qf88477 8 18 ultimately ultimately ADV tx31qf88477 8 19 their their PRON tx31qf88477 8 20 ability ability NOUN tx31qf88477 8 21 to to PART tx31qf88477 8 22 survive survive VERB tx31qf88477 8 23 and/or and/or CCONJ tx31qf88477 8 24 contribute contribute VERB tx31qf88477 8 25 to to ADP tx31qf88477 8 26 mg mg NOUN tx31qf88477 8 27 morphogenesis morphogenesis NOUN tx31qf88477 8 28 is be AUX tx31qf88477 8 29 compromised compromise VERB tx31qf88477 8 30 , , PUNCT tx31qf88477 8 31 resulting result VERB tx31qf88477 8 32 in in ADP tx31qf88477 8 33 small small ADJ tx31qf88477 8 34 dysmorphic dysmorphic ADJ tx31qf88477 8 35 mammary mammary NOUN tx31qf88477 8 36 acini acini NOUN tx31qf88477 8 37 in in ADP tx31qf88477 8 38 vitro vitro X tx31qf88477 8 39 . . PUNCT tx31qf88477 9 1 in in ADP tx31qf88477 9 2 vivo vivo PROPN tx31qf88477 9 3 , , PUNCT tx31qf88477 9 4 the the DET tx31qf88477 9 5 ko ko PROPN tx31qf88477 9 6 mecs mecs PROPN tx31qf88477 9 7 are be AUX tx31qf88477 9 8 rapidly rapidly ADV tx31qf88477 9 9 outcompeted outcompete VERB tx31qf88477 9 10 by by ADP tx31qf88477 9 11 wildtype wildtype PROPN tx31qf88477 9 12 ( ( PUNCT tx31qf88477 9 13 wt wt PROPN tx31qf88477 9 14 ) ) PUNCT tx31qf88477 9 15 mecs mecs PROPN tx31qf88477 9 16 . . PUNCT tx31qf88477 10 1 conversely conversely ADV tx31qf88477 10 2 , , PUNCT tx31qf88477 10 3 when when SCONJ tx31qf88477 10 4 cdc42 cdc42 NOUN tx31qf88477 10 5 is be AUX tx31qf88477 10 6 overexpressed overexpresse VERB tx31qf88477 10 7 , , PUNCT tx31qf88477 10 8 the the DET tx31qf88477 10 9 polarity polarity NOUN tx31qf88477 10 10 complex complex NOUN tx31qf88477 10 11 can can AUX tx31qf88477 10 12 form form VERB tx31qf88477 10 13 but but CCONJ tx31qf88477 10 14 the the DET tx31qf88477 10 15 signaling signal VERB tx31qf88477 10 16 downstream downstream NOUN tx31qf88477 10 17 of of ADP tx31qf88477 10 18 this this DET tx31qf88477 10 19 complex complex NOUN tx31qf88477 10 20 may may AUX tx31qf88477 10 21 become become VERB tx31qf88477 10 22 unbalanced unbalanced ADJ tx31qf88477 10 23 . . PUNCT tx31qf88477 11 1 the the DET tx31qf88477 11 2 tight tight ADJ tx31qf88477 11 3 , , PUNCT tx31qf88477 11 4 spatial spatial ADJ tx31qf88477 11 5 and and CCONJ tx31qf88477 11 6 temporal temporal ADJ tx31qf88477 11 7 control control NOUN tx31qf88477 11 8 that that PRON tx31qf88477 11 9 is be AUX tx31qf88477 11 10 important important ADJ tx31qf88477 11 11 for for ADP tx31qf88477 11 12 normal normal ADJ tx31qf88477 11 13 development development NOUN tx31qf88477 11 14 may may AUX tx31qf88477 11 15 be be AUX tx31qf88477 11 16 tipped tip VERB tx31qf88477 11 17 , , PUNCT tx31qf88477 11 18 causing cause VERB tx31qf88477 11 19 increased increase VERB tx31qf88477 11 20 contractility contractility NOUN tx31qf88477 11 21 and and CCONJ tx31qf88477 11 22 aberrant aberrant ADJ tx31qf88477 11 23 migration migration NOUN tx31qf88477 11 24 , , PUNCT tx31qf88477 11 25 resulting result VERB tx31qf88477 11 26 in in ADP tx31qf88477 11 27 a a DET tx31qf88477 11 28 dysmorphic dysmorphic ADJ tx31qf88477 11 29 hyperbranched hyperbranche VERB tx31qf88477 11 30 mg mg PROPN tx31qf88477 11 31 . . PUNCT tx31qf88477 12 1 evidence evidence NOUN tx31qf88477 12 2 from from ADP tx31qf88477 12 3 our our PRON tx31qf88477 12 4 cdc42 cdc42 ADJ tx31qf88477 12 5 ko ko NOUN tx31qf88477 12 6 and and CCONJ tx31qf88477 12 7 cdc42 cdc42 PROPN tx31qf88477 12 8 oe oe PROPN tx31qf88477 12 9 mouse mouse PROPN tx31qf88477 12 10 mg mg PROPN tx31qf88477 12 11 development development NOUN tx31qf88477 12 12 models model NOUN tx31qf88477 12 13 , , PUNCT tx31qf88477 12 14 together together ADV tx31qf88477 12 15 with with ADP tx31qf88477 12 16 published published ADJ tx31qf88477 12 17 studies study NOUN tx31qf88477 12 18 , , PUNCT tx31qf88477 12 19 suggest suggest VERB tx31qf88477 12 20 that that SCONJ tx31qf88477 12 21 cdc42 cdc42 NOUN tx31qf88477 12 22 plays play VERB tx31qf88477 12 23 an an DET tx31qf88477 12 24 important important ADJ tx31qf88477 12 25 role role NOUN tx31qf88477 12 26 in in ADP tx31qf88477 12 27 breast breast NOUN tx31qf88477 12 28 cancer cancer NOUN tx31qf88477 12 29 . . PUNCT tx31qf88477 13 1 our our PRON tx31qf88477 13 2 work work NOUN tx31qf88477 13 3 provides provide VERB tx31qf88477 13 4 strong strong ADJ tx31qf88477 13 5 motivation motivation NOUN tx31qf88477 13 6 for for ADP tx31qf88477 13 7 future future ADJ tx31qf88477 13 8 studies study NOUN tx31qf88477 13 9 investigating investigate VERB tx31qf88477 13 10 the the DET tx31qf88477 13 11 role role NOUN tx31qf88477 13 12 of of ADP tx31qf88477 13 13 cdc42 cdc42 NOUN tx31qf88477 13 14 in in ADP tx31qf88477 13 15 mouse mouse NOUN tx31qf88477 13 16 mammary mammary ADJ tx31qf88477 13 17 tumor tumor NOUN tx31qf88477 13 18 models model NOUN tx31qf88477 13 19 . . PUNCT