id sid tid token lemma pos tx31qf8842h 1 1 the the DET tx31qf8842h 1 2 interaction interaction NOUN tx31qf8842h 1 3 of of ADP tx31qf8842h 1 4 peripheral peripheral ADJ tx31qf8842h 1 5 proteins protein NOUN tx31qf8842h 1 6 with with ADP tx31qf8842h 1 7 cellular cellular ADJ tx31qf8842h 1 8 lipids lipid NOUN tx31qf8842h 1 9 is be AUX tx31qf8842h 1 10 essential essential ADJ tx31qf8842h 1 11 to to ADP tx31qf8842h 1 12 cellular cellular ADJ tx31qf8842h 1 13 function function NOUN tx31qf8842h 1 14 and and CCONJ tx31qf8842h 1 15 homeostasis homeostasis NOUN tx31qf8842h 1 16 . . PUNCT tx31qf8842h 2 1 several several ADJ tx31qf8842h 2 2 conserved conserved ADJ tx31qf8842h 2 3 protein protein NOUN tx31qf8842h 2 4 families family NOUN tx31qf8842h 2 5 dock dock VERB tx31qf8842h 2 6 at at ADP tx31qf8842h 2 7 cellular cellular ADJ tx31qf8842h 2 8 membranes membrane NOUN tx31qf8842h 2 9 in in ADP tx31qf8842h 2 10 order order NOUN tx31qf8842h 2 11 to to PART tx31qf8842h 2 12 target target VERB tx31qf8842h 2 13 catalytic catalytic ADJ tx31qf8842h 2 14 domains domain NOUN tx31qf8842h 2 15 to to ADP tx31qf8842h 2 16 membrane membrane NOUN tx31qf8842h 2 17 - - PUNCT tx31qf8842h 2 18 localized localize VERB tx31qf8842h 2 19 substrates substrate NOUN tx31qf8842h 2 20 , , PUNCT tx31qf8842h 2 21 to to PART tx31qf8842h 2 22 metabolize metabolize VERB tx31qf8842h 2 23 lipids lipid NOUN tx31qf8842h 2 24 , , PUNCT tx31qf8842h 2 25 and and CCONJ tx31qf8842h 2 26 to to ADP tx31qf8842h 2 27 spatially spatially ADV tx31qf8842h 2 28 re re VERB tx31qf8842h 2 29 - - VERB tx31qf8842h 2 30 organize organize VERB tx31qf8842h 2 31 or or CCONJ tx31qf8842h 2 32 deform deform NOUN tx31qf8842h 2 33 membranes membrane NOUN tx31qf8842h 2 34 . . PUNCT tx31qf8842h 3 1 this this DET tx31qf8842h 3 2 thesis thesis NOUN tx31qf8842h 3 3 is be AUX tx31qf8842h 3 4 an an DET tx31qf8842h 3 5 investigation investigation NOUN tx31qf8842h 3 6 of of ADP tx31qf8842h 3 7 the the DET tx31qf8842h 3 8 biophysical biophysical ADJ tx31qf8842h 3 9 and and CCONJ tx31qf8842h 3 10 biochemical biochemical ADJ tx31qf8842h 3 11 mechanisms mechanism NOUN tx31qf8842h 3 12 of of ADP tx31qf8842h 3 13 phosphoinositide phosphoinositide NOUN tx31qf8842h 3 14 - - PUNCT tx31qf8842h 3 15 binding bind VERB tx31qf8842h 3 16 proteins protein NOUN tx31qf8842h 3 17 at at ADP tx31qf8842h 3 18 cellular cellular ADJ tx31qf8842h 3 19 membranes membrane NOUN tx31qf8842h 3 20 . . PUNCT tx31qf8842h 4 1 beginning begin VERB tx31qf8842h 4 2 with with ADP tx31qf8842h 4 3 an an DET tx31qf8842h 4 4 investigation investigation NOUN tx31qf8842h 4 5 of of ADP tx31qf8842h 4 6 the the DET tx31qf8842h 4 7 pi(4)p pi(4)p NOUN tx31qf8842h 4 8 - - PUNCT tx31qf8842h 4 9 binding bind VERB tx31qf8842h 4 10 protein protein NOUN tx31qf8842h 4 11 fapp1 fapp1 NOUN tx31qf8842h 4 12 and and CCONJ tx31qf8842h 4 13 its its PRON tx31qf8842h 4 14 role role NOUN tx31qf8842h 4 15 in in ADP tx31qf8842h 4 16 golgi golgi PROPN tx31qf8842h 4 17 vesicle vesicle NOUN tx31qf8842h 4 18 formation formation NOUN tx31qf8842h 4 19 and and CCONJ tx31qf8842h 4 20 trafficking trafficking NOUN tx31qf8842h 4 21 , , PUNCT tx31qf8842h 4 22 it it PRON tx31qf8842h 4 23 then then ADV tx31qf8842h 4 24 progresses progress VERB tx31qf8842h 4 25 to to ADP tx31qf8842h 4 26 an an DET tx31qf8842h 4 27 investigation investigation NOUN tx31qf8842h 4 28 of of ADP tx31qf8842h 4 29 a a DET tx31qf8842h 4 30 family family NOUN tx31qf8842h 4 31 of of ADP tx31qf8842h 4 32 lipid lipid NOUN tx31qf8842h 4 33 - - PUNCT tx31qf8842h 4 34 binding bind VERB tx31qf8842h 4 35 c2 c2 PROPN tx31qf8842h 4 36 domains domain NOUN tx31qf8842h 4 37 present present ADJ tx31qf8842h 4 38 in in ADP tx31qf8842h 4 39 mammalian mammalian ADJ tx31qf8842h 4 40 ubiquitin ubiquitin NOUN tx31qf8842h 4 41 ligases ligase NOUN tx31qf8842h 4 42 , , PUNCT tx31qf8842h 4 43 and and CCONJ tx31qf8842h 4 44 of of ADP tx31qf8842h 4 45 the the DET tx31qf8842h 4 46 ebola ebola PROPN tx31qf8842h 4 47 virus virus PROPN tx31qf8842h 4 48 lipid lipid NOUN tx31qf8842h 4 49 - - PUNCT tx31qf8842h 4 50 binding bind VERB tx31qf8842h 4 51 protein protein NOUN tx31qf8842h 4 52 vp40 vp40 PROPN tx31qf8842h 4 53 . . PUNCT tx31qf8842h 5 1 the the DET tx31qf8842h 5 2 c2 c2 PROPN tx31qf8842h 5 3 domains domain NOUN tx31qf8842h 5 4 , , PUNCT tx31qf8842h 5 5 present present ADJ tx31qf8842h 5 6 in in ADP tx31qf8842h 5 7 the the DET tx31qf8842h 5 8 nedd4 nedd4 ADJ tx31qf8842h 5 9 family family NOUN tx31qf8842h 5 10 of of ADP tx31qf8842h 5 11 ubiquitin ubiquitin NOUN tx31qf8842h 5 12 ligases ligase NOUN tx31qf8842h 5 13 , , PUNCT tx31qf8842h 5 14 are be AUX tx31qf8842h 5 15 shown show VERB tx31qf8842h 5 16 to to PART tx31qf8842h 5 17 have have VERB tx31qf8842h 5 18 novel novel ADJ tx31qf8842h 5 19 properties property NOUN tx31qf8842h 5 20 as as ADP tx31qf8842h 5 21 both both PRON tx31qf8842h 5 22 phosphoinositide phosphoinositide NOUN tx31qf8842h 5 23 - - PUNCT tx31qf8842h 5 24 binding bind VERB tx31qf8842h 5 25 and and CCONJ tx31qf8842h 5 26 charge charge VERB tx31qf8842h 5 27 sensing sense VERB tx31qf8842h 5 28 domains domain NOUN tx31qf8842h 5 29 . . PUNCT tx31qf8842h 6 1 as as SCONJ tx31qf8842h 6 2 these these DET tx31qf8842h 6 3 nedd4 nedd4 ADJ tx31qf8842h 6 4 ubiquitin ubiquitin NOUN tx31qf8842h 6 5 ligases ligase NOUN tx31qf8842h 6 6 have have AUX tx31qf8842h 6 7 been be AUX tx31qf8842h 6 8 shown show VERB tx31qf8842h 6 9 to to PART tx31qf8842h 6 10 regulate regulate VERB tx31qf8842h 6 11 important important ADJ tx31qf8842h 6 12 cellular cellular ADJ tx31qf8842h 6 13 processes process NOUN tx31qf8842h 6 14 such such ADJ tx31qf8842h 6 15 as as ADP tx31qf8842h 6 16 membrane membrane NOUN tx31qf8842h 6 17 receptor receptor NOUN tx31qf8842h 6 18 endocytosis endocytosis NOUN tx31qf8842h 6 19 , , PUNCT tx31qf8842h 6 20 growth growth NOUN tx31qf8842h 6 21 factor factor NOUN tx31qf8842h 6 22 signaling signal VERB tx31qf8842h 6 23 , , PUNCT tx31qf8842h 6 24 epithelial epithelial ADJ tx31qf8842h 6 25 to to ADP tx31qf8842h 6 26 mesenchymal mesenchymal ADJ tx31qf8842h 6 27 transition transition NOUN tx31qf8842h 6 28 in in ADP tx31qf8842h 6 29 cancer cancer NOUN tx31qf8842h 6 30 cells cell NOUN tx31qf8842h 6 31 , , PUNCT tx31qf8842h 6 32 and and CCONJ tx31qf8842h 6 33 viral viral ADJ tx31qf8842h 6 34 egress egress NOUN tx31qf8842h 6 35 , , PUNCT tx31qf8842h 6 36 this this DET tx31qf8842h 6 37 work work NOUN tx31qf8842h 6 38 provides provide VERB tx31qf8842h 6 39 a a DET tx31qf8842h 6 40 platform platform NOUN tx31qf8842h 6 41 on on ADP tx31qf8842h 6 42 which which PRON tx31qf8842h 6 43 to to PART tx31qf8842h 6 44 understand understand VERB tx31qf8842h 6 45 how how SCONJ tx31qf8842h 6 46 these these DET tx31qf8842h 6 47 proteins protein NOUN tx31qf8842h 6 48 regulate regulate VERB tx31qf8842h 6 49 cellular cellular ADJ tx31qf8842h 6 50 substrates substrate NOUN tx31qf8842h 6 51 via via ADP tx31qf8842h 6 52 their their PRON tx31qf8842h 6 53 localization localization NOUN tx31qf8842h 6 54 to to ADP tx31qf8842h 6 55 membranes membrane NOUN tx31qf8842h 6 56 . . PUNCT tx31qf8842h 7 1 the the DET tx31qf8842h 7 2 study study NOUN tx31qf8842h 7 3 of of ADP tx31qf8842h 7 4 ebola ebola PROPN tx31qf8842h 7 5 vp40 vp40 PROPN tx31qf8842h 7 6 provides provide VERB tx31qf8842h 7 7 greater great ADJ tx31qf8842h 7 8 detail detail NOUN tx31qf8842h 7 9 on on ADP tx31qf8842h 7 10 the the DET tx31qf8842h 7 11 anionic anionic PROPN tx31qf8842h 7 12 lipid lipid NOUN tx31qf8842h 7 13 - - PUNCT tx31qf8842h 7 14 targeting target VERB tx31qf8842h 7 15 mechanism mechanism NOUN tx31qf8842h 7 16 of of ADP tx31qf8842h 7 17 the the DET tx31qf8842h 7 18 ebola ebola PROPN tx31qf8842h 7 19 virus virus NOUN tx31qf8842h 7 20 protein protein NOUN tx31qf8842h 7 21 via via ADP tx31qf8842h 7 22 phospholipids phospholipid NOUN tx31qf8842h 7 23 , , PUNCT tx31qf8842h 7 24 revealing reveal VERB tx31qf8842h 7 25 it it PRON tx31qf8842h 7 26 to to PART tx31qf8842h 7 27 have have VERB tx31qf8842h 7 28 specific specific ADJ tx31qf8842h 7 29 affinity affinity NOUN tx31qf8842h 7 30 for for ADP tx31qf8842h 7 31 phosphoinosities phosphoinositie NOUN tx31qf8842h 7 32 at at ADP tx31qf8842h 7 33 the the DET tx31qf8842h 7 34 plasma plasma NOUN tx31qf8842h 7 35 membrane membrane NOUN tx31qf8842h 7 36 in in ADP tx31qf8842h 7 37 live live ADJ tx31qf8842h 7 38 cells cell NOUN tx31qf8842h 7 39 . . PUNCT tx31qf8842h 8 1 in in ADP tx31qf8842h 8 2 addition addition NOUN tx31qf8842h 8 3 , , PUNCT tx31qf8842h 8 4 a a DET tx31qf8842h 8 5 novel novel NOUN tx31qf8842h 8 6 elisa elisa NOUN tx31qf8842h 8 7 - - PUNCT tx31qf8842h 8 8 based base VERB tx31qf8842h 8 9 assay assay PROPN tx31qf8842h 8 10 to to PART tx31qf8842h 8 11 assess assess VERB tx31qf8842h 8 12 virus virus NOUN tx31qf8842h 8 13 - - PUNCT tx31qf8842h 8 14 like like ADJ tx31qf8842h 8 15 particle particle NOUN tx31qf8842h 8 16 egress egress NOUN tx31qf8842h 8 17 from from ADP tx31qf8842h 8 18 vp40 vp40 PROPN tx31qf8842h 8 19 - - PUNCT tx31qf8842h 8 20 transfected transfecte VERB tx31qf8842h 8 21 cells cell NOUN tx31qf8842h 8 22 is be AUX tx31qf8842h 8 23 detailed detail VERB tx31qf8842h 8 24 . . PUNCT tx31qf8842h 9 1 this this DET tx31qf8842h 9 2 data data NOUN tx31qf8842h 9 3 provides provide VERB tx31qf8842h 9 4 a a DET tx31qf8842h 9 5 better well ADJ tx31qf8842h 9 6 understanding understanding NOUN tx31qf8842h 9 7 of of ADP tx31qf8842h 9 8 how how SCONJ tx31qf8842h 9 9 the the DET tx31qf8842h 9 10 ebola ebola PROPN tx31qf8842h 9 11 matrix matrix NOUN tx31qf8842h 9 12 protein protein NOUN tx31qf8842h 9 13 targets target VERB tx31qf8842h 9 14 membranes membrane NOUN tx31qf8842h 9 15 in in ADP tx31qf8842h 9 16 virus virus NOUN tx31qf8842h 9 17 replication replication NOUN tx31qf8842h 9 18 . . PUNCT tx31qf8842h 10 1 overall overall ADV tx31qf8842h 10 2 , , PUNCT tx31qf8842h 10 3 this this DET tx31qf8842h 10 4 work work NOUN tx31qf8842h 10 5 provides provide VERB tx31qf8842h 10 6 the the DET tx31qf8842h 10 7 lipid lipid NOUN tx31qf8842h 10 8 research research NOUN tx31qf8842h 10 9 community community NOUN tx31qf8842h 10 10 with with ADP tx31qf8842h 10 11 a a DET tx31qf8842h 10 12 greater great ADJ tx31qf8842h 10 13 understanding understanding NOUN tx31qf8842h 10 14 of of ADP tx31qf8842h 10 15 specific specific ADJ tx31qf8842h 10 16 protein protein NOUN tx31qf8842h 10 17 - - PUNCT tx31qf8842h 10 18 lipid lipid NOUN tx31qf8842h 10 19 interactions interaction NOUN tx31qf8842h 10 20 and and CCONJ tx31qf8842h 10 21 also also ADV tx31qf8842h 10 22 with with ADP tx31qf8842h 10 23 new new ADJ tx31qf8842h 10 24 insights insight NOUN tx31qf8842h 10 25 on on ADP tx31qf8842h 10 26 the the DET tx31qf8842h 10 27 diversity diversity NOUN tx31qf8842h 10 28 of of ADP tx31qf8842h 10 29 lipid lipid NOUN tx31qf8842h 10 30 - - PUNCT tx31qf8842h 10 31 binding bind VERB tx31qf8842h 10 32 mechanisms mechanism NOUN tx31qf8842h 10 33 in in ADP tx31qf8842h 10 34 the the DET tx31qf8842h 10 35 c2 c2 PROPN tx31qf8842h 10 36 domain domain NOUN tx31qf8842h 10 37 family family NOUN tx31qf8842h 10 38 . . PUNCT