id sid tid token lemma pos tq57np22b09 1 1 pseudomonas pseudomonas PROPN tq57np22b09 1 2 aeruginosa aeruginosa PROPN tq57np22b09 1 3 is be AUX tq57np22b09 1 4 an an DET tq57np22b09 1 5 aggressive aggressive ADJ tq57np22b09 1 6 human human ADJ tq57np22b09 1 7 bacterial bacterial ADJ tq57np22b09 1 8 pathogen pathogen PROPN tq57np22b09 1 9 . . PUNCT tq57np22b09 2 1 a a DET tq57np22b09 2 2 mainstay mainstay NOUN tq57np22b09 2 3 of of ADP tq57np22b09 2 4 chemotherapy chemotherapy NOUN tq57np22b09 2 5 of of ADP tq57np22b09 2 6 p. p. PROPN tq57np22b09 2 7 aeruginosa aeruginosa PROPN tq57np22b09 2 8 infection infection NOUN tq57np22b09 2 9 of of ADP tq57np22b09 2 10 the the DET tq57np22b09 2 11 skin skin NOUN tq57np22b09 2 12 ( ( PUNCT tq57np22b09 2 13 following follow VERB tq57np22b09 2 14 burns burn NOUN tq57np22b09 2 15 ) ) PUNCT tq57np22b09 2 16 and and CCONJ tq57np22b09 2 17 the the DET tq57np22b09 2 18 lungs lung NOUN tq57np22b09 2 19 ( ( PUNCT tq57np22b09 2 20 in in ADP tq57np22b09 2 21 cystic cystic ADJ tq57np22b09 2 22 fibrosis fibrosis NOUN tq57np22b09 2 23 ) ) PUNCT tq57np22b09 2 24 is be AUX tq57np22b09 2 25 the the DET tq57np22b09 2 26 penicillin penicillin NOUN tq57np22b09 2 27 - - PUNCT tq57np22b09 2 28 class class NOUN tq57np22b09 2 29 of of ADP tq57np22b09 2 30 antibiotics antibiotic NOUN tq57np22b09 2 31 . . PUNCT tq57np22b09 3 1 my my PRON tq57np22b09 3 2 research research NOUN tq57np22b09 3 3 addresses address VERB tq57np22b09 3 4 the the DET tq57np22b09 3 5 nexus nexus NOUN tq57np22b09 3 6 between between ADP tq57np22b09 3 7 the the DET tq57np22b09 3 8 detection detection NOUN tq57np22b09 3 9 of of ADP tq57np22b09 3 10 these these DET tq57np22b09 3 11 antibiotics antibiotic NOUN tq57np22b09 3 12 and and CCONJ tq57np22b09 3 13 the the DET tq57np22b09 3 14 initiation initiation NOUN tq57np22b09 3 15 of of ADP tq57np22b09 3 16 resistance resistance NOUN tq57np22b09 3 17 mechanisms mechanism NOUN tq57np22b09 3 18 by by ADP tq57np22b09 3 19 this this DET tq57np22b09 3 20 bacterium bacterium NOUN tq57np22b09 3 21 . . PUNCT tq57np22b09 4 1 the the DET tq57np22b09 4 2 penicillin penicillin PROPN tq57np22b09 4 3 antibiotics antibiotic NOUN tq57np22b09 4 4 use use VERB tq57np22b09 4 5 their their PRON tq57np22b09 4 6 β β NUM tq57np22b09 4 7 - - PUNCT tq57np22b09 4 8 lactam lactam NOUN tq57np22b09 4 9 functional functional ADJ tq57np22b09 4 10 group group NOUN tq57np22b09 4 11 to to PART tq57np22b09 4 12 damage damage VERB tq57np22b09 4 13 the the DET tq57np22b09 4 14 cell cell NOUN tq57np22b09 4 15 wall wall NOUN tq57np22b09 4 16 of of ADP tq57np22b09 4 17 the the DET tq57np22b09 4 18 bacterium bacterium NOUN tq57np22b09 4 19 . . PUNCT tq57np22b09 5 1 the the DET tq57np22b09 5 2 p. p. PROPN tq57np22b09 5 3 aeruginosa aeruginosa PROPN tq57np22b09 5 4 bacterium bacterium NOUN tq57np22b09 5 5 detects detect VERB tq57np22b09 5 6 this this DET tq57np22b09 5 7 damage damage NOUN tq57np22b09 5 8 by by ADP tq57np22b09 5 9 monitoring monitor VERB tq57np22b09 5 10 cell cell NOUN tq57np22b09 5 11 - - PUNCT tq57np22b09 5 12 wall wall NOUN tq57np22b09 5 13 metabolite metabolite PROPN tq57np22b09 5 14 flux flux PROPN tq57np22b09 5 15 through through ADP tq57np22b09 5 16 a a DET tq57np22b09 5 17 superfamily superfamily NOUN tq57np22b09 5 18 of of ADP tq57np22b09 5 19 cell cell NOUN tq57np22b09 5 20 - - PUNCT tq57np22b09 5 21 wall wall NOUN tq57np22b09 5 22 maintaining maintain VERB tq57np22b09 5 23 enzymes enzyme NOUN tq57np22b09 5 24 , , PUNCT tq57np22b09 5 25 known know VERB tq57np22b09 5 26 collectively collectively ADV tq57np22b09 5 27 as as ADP tq57np22b09 5 28 the the DET tq57np22b09 5 29 lts lts PROPN tq57np22b09 5 30 . . PUNCT tq57np22b09 6 1 perturbation perturbation NOUN tq57np22b09 6 2 in in ADP tq57np22b09 6 3 this this DET tq57np22b09 6 4 metabolite metabolite PROPN tq57np22b09 6 5 flux flux NOUN tq57np22b09 6 6 initiates initiate VERB tq57np22b09 6 7 a a DET tq57np22b09 6 8 transmembrane transmembrane ADJ tq57np22b09 6 9 signaling signal VERB tq57np22b09 6 10 pathway pathway NOUN tq57np22b09 6 11 that that PRON tq57np22b09 6 12 culminates culminate VERB tq57np22b09 6 13 in in ADP tq57np22b09 6 14 the the DET tq57np22b09 6 15 activation activation NOUN tq57np22b09 6 16 of of ADP tq57np22b09 6 17 the the DET tq57np22b09 6 18 ampr ampr ADJ tq57np22b09 6 19 transcription transcription NOUN tq57np22b09 6 20 factor factor NOUN tq57np22b09 6 21 . . PUNCT tq57np22b09 7 1 activation activation NOUN tq57np22b09 7 2 of of ADP tq57np22b09 7 3 ampr ampr NOUN tq57np22b09 7 4 elicits elicit VERB tq57np22b09 7 5 induction induction NOUN tq57np22b09 7 6 of of ADP tq57np22b09 7 7 the the DET tq57np22b09 7 8 ampc ampc NOUN tq57np22b09 7 9 β β PROPN tq57np22b09 7 10 - - PUNCT tq57np22b09 7 11 lactamase lactamase PROPN tq57np22b09 7 12 , , PUNCT tq57np22b09 7 13 an an DET tq57np22b09 7 14 enzyme enzyme NOUN tq57np22b09 7 15 that that PRON tq57np22b09 7 16 destroys destroy VERB tq57np22b09 7 17 the the DET tq57np22b09 7 18 β β NOUN tq57np22b09 7 19 - - PUNCT tq57np22b09 7 20 lactam lactam NOUN tq57np22b09 7 21 antibiotic antibiotic NOUN tq57np22b09 7 22 . . PUNCT tq57np22b09 8 1 my my PRON tq57np22b09 8 2 research research NOUN tq57np22b09 8 3 characterized characterize VERB tq57np22b09 8 4 the the DET tq57np22b09 8 5 lt lt PROPN tq57np22b09 8 6 enzymes enzyme NOUN tq57np22b09 8 7 of of ADP tq57np22b09 8 8 p. p. PROPN tq57np22b09 8 9 aeruginosa aeruginosa PROPN tq57np22b09 8 10 , , PUNCT tq57np22b09 8 11 identified identify VERB tq57np22b09 8 12 the the DET tq57np22b09 8 13 molecular molecular ADJ tq57np22b09 8 14 structure structure NOUN tq57np22b09 8 15 of of ADP tq57np22b09 8 16 the the DET tq57np22b09 8 17 cell cell NOUN tq57np22b09 8 18 - - PUNCT tq57np22b09 8 19 wall wall NOUN tq57np22b09 8 20 fragments fragment NOUN tq57np22b09 8 21 used use VERB tq57np22b09 8 22 by by ADP tq57np22b09 8 23 these these DET tq57np22b09 8 24 lt lt PROPN tq57np22b09 8 25 enzymes enzyme NOUN tq57np22b09 8 26 to to PART tq57np22b09 8 27 detect detect VERB tq57np22b09 8 28 the the DET tq57np22b09 8 29 presence presence NOUN tq57np22b09 8 30 of of ADP tq57np22b09 8 31 these these DET tq57np22b09 8 32 antibiotics antibiotic NOUN tq57np22b09 8 33 , , PUNCT tq57np22b09 8 34 and and CCONJ tq57np22b09 8 35 characterized characterize VERB tq57np22b09 8 36 the the DET tq57np22b09 8 37 transcription transcription NOUN tq57np22b09 8 38 factor factor NOUN tq57np22b09 8 39 activation activation NOUN tq57np22b09 8 40 mechanism mechanism NOUN tq57np22b09 8 41 for for ADP tq57np22b09 8 42 the the DET tq57np22b09 8 43 expression expression NOUN tq57np22b09 8 44 of of ADP tq57np22b09 8 45 the the DET tq57np22b09 8 46 resistance resistance NOUN tq57np22b09 8 47 mechanism mechanism NOUN tq57np22b09 8 48 . . PUNCT tq57np22b09 9 1 i i PRON tq57np22b09 9 2 developed develop VERB tq57np22b09 9 3 a a DET tq57np22b09 9 4 fluorescent fluorescent NOUN tq57np22b09 9 5 reporter reporter NOUN tq57np22b09 9 6 assay assay VERB tq57np22b09 9 7 to to PART tq57np22b09 9 8 probe probe VERB tq57np22b09 9 9 the the DET tq57np22b09 9 10 decisive decisive ADJ tq57np22b09 9 11 impact impact NOUN tq57np22b09 9 12 of of ADP tq57np22b09 9 13 the the DET tq57np22b09 9 14 relationship relationship NOUN tq57np22b09 9 15 between between ADP tq57np22b09 9 16 the the DET tq57np22b09 9 17 loss loss NOUN tq57np22b09 9 18 of of ADP tq57np22b09 9 19 lt lt PROPN tq57np22b09 9 20 function function NOUN tq57np22b09 9 21 and and CCONJ tq57np22b09 9 22 the the DET tq57np22b09 9 23 efficacy efficacy NOUN tq57np22b09 9 24 of of ADP tq57np22b09 9 25 the the DET tq57np22b09 9 26 resistance resistance NOUN tq57np22b09 9 27 mechanism mechanism NOUN tq57np22b09 9 28 . . PUNCT tq57np22b09 10 1 i i PRON tq57np22b09 10 2 evaluated evaluate VERB tq57np22b09 10 3 a a DET tq57np22b09 10 4 naturally naturally ADV tq57np22b09 10 5 occurring occur VERB tq57np22b09 10 6 inhibitor inhibitor NOUN tq57np22b09 10 7 of of ADP tq57np22b09 10 8 the the DET tq57np22b09 10 9 lts lts NOUN tq57np22b09 10 10 and and CCONJ tq57np22b09 10 11 demonstrated demonstrate VERB tq57np22b09 10 12 that that SCONJ tq57np22b09 10 13 it it PRON tq57np22b09 10 14 synergizes synergize VERB tq57np22b09 10 15 with with ADP tq57np22b09 10 16 clinical clinical ADJ tq57np22b09 10 17 front front ADJ tq57np22b09 10 18 - - PUNCT tq57np22b09 10 19 line line NOUN tq57np22b09 10 20 antibiotics antibiotic NOUN tq57np22b09 10 21 against against ADP tq57np22b09 10 22 p. p. PROPN tq57np22b09 10 23 aeruginosa aeruginosa PROPN tq57np22b09 10 24 to to PART tq57np22b09 10 25 affect affect VERB tq57np22b09 10 26 the the DET tq57np22b09 10 27 rapid rapid ADJ tq57np22b09 10 28 cell cell NOUN tq57np22b09 10 29 lysis lysis NOUN tq57np22b09 10 30 of of ADP tq57np22b09 10 31 this this DET tq57np22b09 10 32 bacterium bacterium NOUN tq57np22b09 10 33 . . PUNCT tq57np22b09 11 1 this this DET tq57np22b09 11 2 observation observation NOUN tq57np22b09 11 3 affirms affirm VERB tq57np22b09 11 4 the the DET tq57np22b09 11 5 lts lts NOUN tq57np22b09 11 6 as as ADP tq57np22b09 11 7 an an DET tq57np22b09 11 8 antibiotic antibiotic ADJ tq57np22b09 11 9 target target NOUN tq57np22b09 11 10 . . PUNCT tq57np22b09 12 1 these these DET tq57np22b09 12 2 findings finding NOUN tq57np22b09 12 3 substantially substantially ADV tq57np22b09 12 4 advance advance VERB tq57np22b09 12 5 our our PRON tq57np22b09 12 6 understanding understanding NOUN tq57np22b09 12 7 of of ADP tq57np22b09 12 8 the the DET tq57np22b09 12 9 resistance resistance NOUN tq57np22b09 12 10 mechanisms mechanism NOUN tq57np22b09 12 11 used use VERB tq57np22b09 12 12 by by ADP tq57np22b09 12 13 bacteria bacteria NOUN tq57np22b09 12 14 to to PART tq57np22b09 12 15 counter counter VERB tq57np22b09 12 16 the the DET tq57np22b09 12 17 β β PROPN tq57np22b09 12 18 - - PUNCT tq57np22b09 12 19 lactam lactam NOUN tq57np22b09 12 20 antibiotics antibiotic NOUN tq57np22b09 12 21 . . PUNCT