id sid tid token lemma pos t148ff39q2r 1 1 bacterial bacterial ADJ t148ff39q2r 1 2 infections infection NOUN t148ff39q2r 1 3 caused cause VERB t148ff39q2r 1 4 by by ADP t148ff39q2r 1 5 multidrug multidrug NOUN t148ff39q2r 1 6 resistant resistant ADJ t148ff39q2r 1 7 ( ( PUNCT t148ff39q2r 1 8 mdr mdr NOUN t148ff39q2r 1 9 ) ) PUNCT t148ff39q2r 1 10 organisms organism NOUN t148ff39q2r 1 11 are be AUX t148ff39q2r 1 12 one one NUM t148ff39q2r 1 13 of of ADP t148ff39q2r 1 14 the the DET t148ff39q2r 1 15 greatest great ADJ t148ff39q2r 1 16 global global ADJ t148ff39q2r 1 17 health health NOUN t148ff39q2r 1 18 threats threat NOUN t148ff39q2r 1 19 . . PUNCT t148ff39q2r 2 1 however however ADV t148ff39q2r 2 2 , , PUNCT t148ff39q2r 2 3 insufficient insufficient ADJ t148ff39q2r 2 4 resources resource NOUN t148ff39q2r 2 5 are be AUX t148ff39q2r 2 6 allocated allocate VERB t148ff39q2r 2 7 to to ADP t148ff39q2r 2 8 the the DET t148ff39q2r 2 9 development development NOUN t148ff39q2r 2 10 of of ADP t148ff39q2r 2 11 novel novel ADJ t148ff39q2r 2 12 strategies strategy NOUN t148ff39q2r 2 13 to to PART t148ff39q2r 2 14 combat combat VERB t148ff39q2r 2 15 this this DET t148ff39q2r 2 16 growing grow VERB t148ff39q2r 2 17 issue issue NOUN t148ff39q2r 2 18 by by ADP t148ff39q2r 2 19 pharmaceutical pharmaceutical ADJ t148ff39q2r 2 20 companies company NOUN t148ff39q2r 2 21 and and CCONJ t148ff39q2r 2 22 governments government NOUN t148ff39q2r 2 23 worldwide worldwide ADV t148ff39q2r 2 24 . . PUNCT t148ff39q2r 3 1 as as ADP t148ff39q2r 3 2 a a DET t148ff39q2r 3 3 result result NOUN t148ff39q2r 3 4 , , PUNCT t148ff39q2r 3 5 antibiotic antibiotic ADJ t148ff39q2r 3 6 resistance resistance NOUN t148ff39q2r 3 7 threatens threaten VERB t148ff39q2r 3 8 to to PART t148ff39q2r 3 9 outpace outpace VERB t148ff39q2r 3 10 antimicrobial antimicrobial ADJ t148ff39q2r 3 11 development development NOUN t148ff39q2r 3 12 potentially potentially ADV t148ff39q2r 3 13 reverting revert VERB t148ff39q2r 3 14 society society NOUN t148ff39q2r 3 15 to to ADP t148ff39q2r 3 16 a a DET t148ff39q2r 3 17 post post ADJ t148ff39q2r 3 18 - - ADJ t148ff39q2r 3 19 antibiotic antibiotic ADJ t148ff39q2r 3 20 era era NOUN t148ff39q2r 3 21 . . PUNCT t148ff39q2r 4 1 as as ADP t148ff39q2r 4 2 a a DET t148ff39q2r 4 3 result result NOUN t148ff39q2r 4 4 , , PUNCT t148ff39q2r 4 5 new new ADJ t148ff39q2r 4 6 approaches approach NOUN t148ff39q2r 4 7 to to PART t148ff39q2r 4 8 identify identify VERB t148ff39q2r 4 9 effective effective ADJ t148ff39q2r 4 10 therapeutics therapeutic NOUN t148ff39q2r 4 11 are be AUX t148ff39q2r 4 12 essential essential ADJ t148ff39q2r 4 13 . . PUNCT t148ff39q2r 5 1 one one NUM t148ff39q2r 5 2 such such ADJ t148ff39q2r 5 3 approach approach NOUN t148ff39q2r 5 4 , , PUNCT t148ff39q2r 5 5 is be AUX t148ff39q2r 5 6 the the DET t148ff39q2r 5 7 identification identification NOUN t148ff39q2r 5 8 of of ADP t148ff39q2r 5 9 antibiotic antibiotic ADJ t148ff39q2r 5 10 adjuvants adjuvant NOUN t148ff39q2r 5 11 that that PRON t148ff39q2r 5 12 re re VERB t148ff39q2r 5 13 - - VERB t148ff39q2r 5 14 sensitize sensitize VERB t148ff39q2r 5 15 resistant resistant ADJ t148ff39q2r 5 16 bacteria bacteria NOUN t148ff39q2r 5 17 to to ADP t148ff39q2r 5 18 an an DET t148ff39q2r 5 19 antibiotic antibiotic ADJ t148ff39q2r 5 20 , , PUNCT t148ff39q2r 5 21 broaden broaden VERB t148ff39q2r 5 22 the the DET t148ff39q2r 5 23 spectrum spectrum NOUN t148ff39q2r 5 24 of of ADP t148ff39q2r 5 25 an an DET t148ff39q2r 5 26 antibiotic antibiotic NOUN t148ff39q2r 5 27 , , PUNCT t148ff39q2r 5 28 or or CCONJ t148ff39q2r 5 29 decrease decrease VERB t148ff39q2r 5 30 the the DET t148ff39q2r 5 31 needed need VERB t148ff39q2r 5 32 antibiotic antibiotic ADJ t148ff39q2r 5 33 dose dose NOUN t148ff39q2r 5 34 , , PUNCT t148ff39q2r 5 35 while while SCONJ t148ff39q2r 5 36 possessing possess VERB t148ff39q2r 5 37 limited limited ADJ t148ff39q2r 5 38 or or CCONJ t148ff39q2r 5 39 no no DET t148ff39q2r 5 40 antimicrobial antimicrobial ADJ t148ff39q2r 5 41 activity activity NOUN t148ff39q2r 5 42 itself itself PRON t148ff39q2r 5 43 . . PUNCT t148ff39q2r 6 1 this this DET t148ff39q2r 6 2 dissertation dissertation NOUN t148ff39q2r 6 3 focuses focus VERB t148ff39q2r 6 4 on on ADP t148ff39q2r 6 5 the the DET t148ff39q2r 6 6 development development NOUN t148ff39q2r 6 7 of of ADP t148ff39q2r 6 8 these these DET t148ff39q2r 6 9 small small ADJ t148ff39q2r 6 10 molecule molecule NOUN t148ff39q2r 6 11 adjuvants.firstly adjuvants.firstly ADV t148ff39q2r 6 12 , , PUNCT t148ff39q2r 6 13 this this DET t148ff39q2r 6 14 work work NOUN t148ff39q2r 6 15 describes describe VERB t148ff39q2r 6 16 the the DET t148ff39q2r 6 17 biofilm biofilm NOUN t148ff39q2r 6 18 inhibitory inhibitory ADJ t148ff39q2r 6 19 activity activity NOUN t148ff39q2r 6 20 of of ADP t148ff39q2r 6 21 a a DET t148ff39q2r 6 22 novel novel ADJ t148ff39q2r 6 23 6 6 NUM t148ff39q2r 6 24 - - PUNCT t148ff39q2r 6 25 substituted substitute VERB t148ff39q2r 6 26 2 2 NUM t148ff39q2r 6 27 - - PUNCT t148ff39q2r 6 28 aminoquinazoline aminoquinazoline PROPN t148ff39q2r 6 29 library library NOUN t148ff39q2r 6 30 against against ADP t148ff39q2r 6 31 mycobacterium mycobacterium PROPN t148ff39q2r 6 32 smegmatis smegmatis PROPN t148ff39q2r 6 33 , , PUNCT t148ff39q2r 6 34 which which PRON t148ff39q2r 6 35 is be AUX t148ff39q2r 6 36 a a DET t148ff39q2r 6 37 model model NOUN t148ff39q2r 6 38 organism organism NOUN t148ff39q2r 6 39 for for ADP t148ff39q2r 6 40 mycobacterium mycobacterium NOUN t148ff39q2r 6 41 tuberculosis tuberculosis NOUN t148ff39q2r 6 42 . . PUNCT t148ff39q2r 7 1 two two NUM t148ff39q2r 7 2 lead lead NOUN t148ff39q2r 7 3 compounds compound NOUN t148ff39q2r 7 4 were be AUX t148ff39q2r 7 5 identified identify VERB t148ff39q2r 7 6 from from ADP t148ff39q2r 7 7 a a DET t148ff39q2r 7 8 structure structure NOUN t148ff39q2r 7 9 - - PUNCT t148ff39q2r 7 10 activity activity NOUN t148ff39q2r 7 11 relationship relationship NOUN t148ff39q2r 7 12 ( ( PUNCT t148ff39q2r 7 13 sar sar PROPN t148ff39q2r 7 14 ) ) PUNCT t148ff39q2r 7 15 study study NOUN t148ff39q2r 7 16 as as ADP t148ff39q2r 7 17 low low ADJ t148ff39q2r 7 18 micromolar micromolar ADJ t148ff39q2r 7 19 inhibitors inhibitor NOUN t148ff39q2r 7 20 of of ADP t148ff39q2r 7 21 m. m. NOUN t148ff39q2r 7 22 smegmatis smegmatis PROPN t148ff39q2r 7 23 biofilms.further biofilms.further PROPN t148ff39q2r 7 24 , , PUNCT t148ff39q2r 7 25 these these DET t148ff39q2r 7 26 compounds compound NOUN t148ff39q2r 7 27 were be AUX t148ff39q2r 7 28 both both PRON t148ff39q2r 7 29 found find VERB t148ff39q2r 7 30 to to PART t148ff39q2r 7 31 be be AUX t148ff39q2r 7 32 nontoxic nontoxic ADJ t148ff39q2r 7 33 alone alone ADV t148ff39q2r 7 34 , , PUNCT t148ff39q2r 7 35 suggesting suggest VERB t148ff39q2r 7 36 this this DET t148ff39q2r 7 37 scaffold scaffold NOUN t148ff39q2r 7 38 may may AUX t148ff39q2r 7 39 be be AUX t148ff39q2r 7 40 effective effective ADJ t148ff39q2r 7 41 to to PART t148ff39q2r 7 42 model model VERB t148ff39q2r 7 43 new new ADJ t148ff39q2r 7 44 adjuvants adjuvant NOUN t148ff39q2r 7 45 . . PUNCT t148ff39q2r 8 1 this this DET t148ff39q2r 8 2 work work NOUN t148ff39q2r 8 3 also also ADV t148ff39q2r 8 4 discusses discuss VERB t148ff39q2r 8 5 a a DET t148ff39q2r 8 6 sar sar PROPN t148ff39q2r 8 7 study study NOUN t148ff39q2r 8 8 conducted conduct VERB t148ff39q2r 8 9 against against ADP t148ff39q2r 8 10 m. m. NOUN t148ff39q2r 8 11 smegmatis smegmatis PROPN t148ff39q2r 8 12 using use VERB t148ff39q2r 8 13 the the DET t148ff39q2r 8 14 natural natural ADJ t148ff39q2r 8 15 product product NOUN t148ff39q2r 8 16 meridianin meridianin PROPN t148ff39q2r 8 17 d d NOUN t148ff39q2r 8 18 as as ADP t148ff39q2r 8 19 the the DET t148ff39q2r 8 20 lead lead ADJ t148ff39q2r 8 21 compound compound NOUN t148ff39q2r 8 22 . . PUNCT t148ff39q2r 9 1 several several ADJ t148ff39q2r 9 2 derivatives derivative NOUN t148ff39q2r 9 3 improved improve VERB t148ff39q2r 9 4 upon upon SCONJ t148ff39q2r 9 5 the the DET t148ff39q2r 9 6 biofilm biofilm NOUN t148ff39q2r 9 7 inhibitory inhibitory ADJ t148ff39q2r 9 8 and and CCONJ t148ff39q2r 9 9 dispersal dispersal ADJ t148ff39q2r 9 10 properties property NOUN t148ff39q2r 9 11 of of ADP t148ff39q2r 9 12 meridianin meridianin PROPN t148ff39q2r 9 13 d. d. PROPN t148ff39q2r 9 14 notably notably PROPN t148ff39q2r 9 15 , , PUNCT t148ff39q2r 9 16 replacement replacement NOUN t148ff39q2r 9 17 of of ADP t148ff39q2r 9 18 the the DET t148ff39q2r 9 19 2 2 NUM t148ff39q2r 9 20 - - PUNCT t148ff39q2r 9 21 aminopyrimidine aminopyrimidine NOUN t148ff39q2r 9 22 moiety moiety NOUN t148ff39q2r 9 23 attached attach VERB t148ff39q2r 9 24 to to ADP t148ff39q2r 9 25 the the DET t148ff39q2r 9 26 indole indole NOUN t148ff39q2r 9 27 with with ADP t148ff39q2r 9 28 a a DET t148ff39q2r 9 29 2 2 NUM t148ff39q2r 9 30 - - PUNCT t148ff39q2r 9 31 aminoimidazole aminoimidazole NOUN t148ff39q2r 9 32 improved improve VERB t148ff39q2r 9 33 antibiofilm antibiofilm NOUN t148ff39q2r 9 34 activity activity NOUN t148ff39q2r 9 35 . . PUNCT t148ff39q2r 10 1 also also ADV t148ff39q2r 10 2 , , PUNCT t148ff39q2r 10 3 halogen halogen NOUN t148ff39q2r 10 4 substitution substitution NOUN t148ff39q2r 10 5 and and CCONJ t148ff39q2r 10 6 position position NOUN t148ff39q2r 10 7 on on ADP t148ff39q2r 10 8 the the DET t148ff39q2r 10 9 indole indole NOUN t148ff39q2r 10 10 impacted impact VERB t148ff39q2r 10 11 activity activity NOUN t148ff39q2r 10 12 . . PUNCT t148ff39q2r 11 1 however however ADV t148ff39q2r 11 2 , , PUNCT t148ff39q2r 11 3 the the DET t148ff39q2r 11 4 sar sar PROPN t148ff39q2r 11 5 revealed reveal VERB t148ff39q2r 11 6 that that SCONJ t148ff39q2r 11 7 meridianin meridianin PROPN t148ff39q2r 11 8 d d NOUN t148ff39q2r 11 9 analogues analogue NOUN t148ff39q2r 11 10 lack lack VERB t148ff39q2r 11 11 β β PROPN t148ff39q2r 11 12 - - PUNCT t148ff39q2r 11 13 lactam lactam NOUN t148ff39q2r 11 14 potentiation potentiation NOUN t148ff39q2r 11 15 activity.next activity.next NOUN t148ff39q2r 11 16 , , PUNCT t148ff39q2r 11 17 this this DET t148ff39q2r 11 18 work work NOUN t148ff39q2r 11 19 expands expand VERB t148ff39q2r 11 20 on on ADP t148ff39q2r 11 21 the the DET t148ff39q2r 11 22 concept concept NOUN t148ff39q2r 11 23 of of ADP t148ff39q2r 11 24 using use VERB t148ff39q2r 11 25 natural natural ADJ t148ff39q2r 11 26 products product NOUN t148ff39q2r 11 27 , , PUNCT t148ff39q2r 11 28 such such ADJ t148ff39q2r 11 29 as as ADP t148ff39q2r 11 30 meridianin meridianin PROPN t148ff39q2r 11 31 d d PROPN t148ff39q2r 11 32 , , PUNCT t148ff39q2r 11 33 as as ADP t148ff39q2r 11 34 antibiotic antibiotic ADJ t148ff39q2r 11 35 adjuvants adjuvant NOUN t148ff39q2r 11 36 . . PUNCT t148ff39q2r 12 1 to to PART t148ff39q2r 12 2 explore explore VERB t148ff39q2r 12 3 this this DET t148ff39q2r 12 4 concept concept NOUN t148ff39q2r 12 5 , , PUNCT t148ff39q2r 12 6 the the DET t148ff39q2r 12 7 national national PROPN t148ff39q2r 12 8 cancer cancer PROPN t148ff39q2r 12 9 institute institute PROPN t148ff39q2r 12 10 ( ( PUNCT t148ff39q2r 12 11 nci nci PROPN t148ff39q2r 12 12 ) ) PUNCT t148ff39q2r 12 13 natural natural ADJ t148ff39q2r 12 14 product product NOUN t148ff39q2r 12 15 library library NOUN t148ff39q2r 12 16 set set NOUN t148ff39q2r 12 17 iv iv PROPN t148ff39q2r 12 18 was be AUX t148ff39q2r 12 19 screened screen VERB t148ff39q2r 12 20 for for ADP t148ff39q2r 12 21 adjuvant adjuvant ADJ t148ff39q2r 12 22 activity activity NOUN t148ff39q2r 12 23 using use VERB t148ff39q2r 12 24 four four NUM t148ff39q2r 12 25 classes class NOUN t148ff39q2r 12 26 of of ADP t148ff39q2r 12 27 antibiotics antibiotic NOUN t148ff39q2r 12 28 ( ( PUNCT t148ff39q2r 12 29 β β NOUN t148ff39q2r 12 30 - - PUNCT t148ff39q2r 12 31 lactams lactams NOUN t148ff39q2r 12 32 , , PUNCT t148ff39q2r 12 33 aminoglycosides aminoglycoside NOUN t148ff39q2r 12 34 , , PUNCT t148ff39q2r 12 35 macrolides macrolide NOUN t148ff39q2r 12 36 , , PUNCT t148ff39q2r 12 37 and and CCONJ t148ff39q2r 12 38 polymyxins polymyxin NOUN t148ff39q2r 12 39 ) ) PUNCT t148ff39q2r 12 40 against against ADP t148ff39q2r 12 41 three three NUM t148ff39q2r 12 42 bacterial bacterial ADJ t148ff39q2r 12 43 pathogens pathogen NOUN t148ff39q2r 12 44 ( ( PUNCT t148ff39q2r 12 45 methicillin methicillin NOUN t148ff39q2r 12 46 - - PUNCT t148ff39q2r 12 47 resistant resistant ADJ t148ff39q2r 12 48 staphylococcus staphylococcus PROPN t148ff39q2r 12 49 aureus aureus PROPN t148ff39q2r 12 50 ( ( PUNCT t148ff39q2r 12 51 mrsa mrsa PROPN t148ff39q2r 12 52 ) ) PUNCT t148ff39q2r 12 53 , , PUNCT t148ff39q2r 12 54 acinetobacter acinetobacter ADJ t148ff39q2r 12 55 baumannii baumannii NOUN t148ff39q2r 12 56 , , PUNCT t148ff39q2r 12 57 and and CCONJ t148ff39q2r 12 58 klebsiella klebsiella PROPN t148ff39q2r 12 59 pneumoniae pneumoniae NOUN t148ff39q2r 12 60 ) ) PUNCT t148ff39q2r 12 61 . . PUNCT t148ff39q2r 13 1 several several ADJ t148ff39q2r 13 2 natural natural ADJ t148ff39q2r 13 3 product product NOUN t148ff39q2r 13 4 adjuvants adjuvant NOUN t148ff39q2r 13 5 were be AUX t148ff39q2r 13 6 identified identify VERB t148ff39q2r 13 7 in in ADP t148ff39q2r 13 8 combination combination NOUN t148ff39q2r 13 9 with with ADP t148ff39q2r 13 10 colistin colistin PROPN t148ff39q2r 13 11 against against ADP t148ff39q2r 13 12 colistin colistin PROPN t148ff39q2r 13 13 - - PUNCT t148ff39q2r 13 14 resistant resistant ADJ t148ff39q2r 13 15 strains strain NOUN t148ff39q2r 13 16 of of ADP t148ff39q2r 13 17 a. a. ADJ t148ff39q2r 13 18 baumannii baumannii NOUN t148ff39q2r 13 19 and and CCONJ t148ff39q2r 13 20 k. k. NOUN t148ff39q2r 13 21 pneumoniae pneumoniae PROPN t148ff39q2r 13 22 . . PUNCT t148ff39q2r 14 1 clorobiocin clorobiocin PROPN t148ff39q2r 14 2 , , PUNCT t148ff39q2r 14 3 novobiocin novobiocin PROPN t148ff39q2r 14 4 , , PUNCT t148ff39q2r 14 5 and and CCONJ t148ff39q2r 14 6 prodigiosin prodigiosin PROPN t148ff39q2r 14 7 were be AUX t148ff39q2r 14 8 determined determine VERB t148ff39q2r 14 9 to to PART t148ff39q2r 14 10 be be AUX t148ff39q2r 14 11 the the DET t148ff39q2r 14 12 most most ADV t148ff39q2r 14 13 effective effective ADJ t148ff39q2r 14 14 adjuvants.lastly adjuvants.lastly ADV t148ff39q2r 14 15 , , PUNCT t148ff39q2r 14 16 this this DET t148ff39q2r 14 17 work work NOUN t148ff39q2r 14 18 discusses discuss VERB t148ff39q2r 14 19 the the DET t148ff39q2r 14 20 antibiofilm antibiofilm NOUN t148ff39q2r 14 21 properties property NOUN t148ff39q2r 14 22 of of ADP t148ff39q2r 14 23 ar-12 ar-12 PRON t148ff39q2r 14 24 against against ADP t148ff39q2r 14 25 m. m. NOUN t148ff39q2r 14 26 smegmatis smegmatis PROPN t148ff39q2r 14 27 and and CCONJ t148ff39q2r 14 28 m. m. NOUN t148ff39q2r 14 29 tuberculosis tuberculosis NOUN t148ff39q2r 14 30 which which PRON t148ff39q2r 14 31 has have AUX t148ff39q2r 14 32 been be AUX t148ff39q2r 14 33 found find VERB t148ff39q2r 14 34 to to PART t148ff39q2r 14 35 selectively selectively ADV t148ff39q2r 14 36 kill kill VERB t148ff39q2r 14 37 these these DET t148ff39q2r 14 38 pathogens pathogen NOUN t148ff39q2r 14 39 only only ADV t148ff39q2r 14 40 when when SCONJ t148ff39q2r 14 41 in in ADP t148ff39q2r 14 42 the the DET t148ff39q2r 14 43 biofilm biofilm NOUN t148ff39q2r 14 44 state state NOUN t148ff39q2r 14 45 . . PUNCT t148ff39q2r 15 1 it it PRON t148ff39q2r 15 2 also also ADV t148ff39q2r 15 3 briefly briefly ADV t148ff39q2r 15 4 discusses discuss VERB t148ff39q2r 15 5 the the DET t148ff39q2r 15 6 synthesis synthesis NOUN t148ff39q2r 15 7 and and CCONJ t148ff39q2r 15 8 results result NOUN t148ff39q2r 15 9 of of ADP t148ff39q2r 15 10 a a DET t148ff39q2r 15 11 preliminary preliminary ADJ t148ff39q2r 15 12 sar sar PROPN t148ff39q2r 15 13 study study NOUN t148ff39q2r 15 14 using use VERB t148ff39q2r 15 15 ar-12 ar-12 PRON t148ff39q2r 15 16 as as ADP t148ff39q2r 15 17 the the DET t148ff39q2r 15 18 lead lead ADJ t148ff39q2r 15 19 compound compound NOUN t148ff39q2r 15 20 . . PUNCT