id	sid	tid	token	lemma	pos
t148ff38s9h	1	1	there	there	PRON
t148ff38s9h	1	2	are	be	VERB
t148ff38s9h	1	3	six	six	NUM
t148ff38s9h	1	4	essential	essential	ADJ
t148ff38s9h	1	5	hallmarks	hallmark	NOUN
t148ff38s9h	1	6	of	of	ADP
t148ff38s9h	1	7	cancer	cancer	NOUN
t148ff38s9h	1	8	that	that	PRON
t148ff38s9h	1	9	are	be	AUX
t148ff38s9h	1	10	targeted	target	VERB
t148ff38s9h	1	11	by	by	ADP
t148ff38s9h	1	12	current	current	ADJ
t148ff38s9h	1	13	therapies	therapy	NOUN
t148ff38s9h	1	14	to	to	PART
t148ff38s9h	1	15	overcome	overcome	VERB
t148ff38s9h	1	16	the	the	DET
t148ff38s9h	1	17	progression	progression	NOUN
t148ff38s9h	1	18	and	and	CCONJ
t148ff38s9h	1	19	metastasis	metastasis	NOUN
t148ff38s9h	1	20	of	of	ADP
t148ff38s9h	1	21	cancer	cancer	NOUN
t148ff38s9h	1	22	cells	cell	NOUN
t148ff38s9h	1	23	.	.	PUNCT
t148ff38s9h	2	1	many	many	ADJ
t148ff38s9h	2	2	current	current	ADJ
t148ff38s9h	2	3	treatments	treatment	NOUN
t148ff38s9h	2	4	lack	lack	VERB
t148ff38s9h	2	5	continued	continue	VERB
t148ff38s9h	2	6	efficacy	efficacy	NOUN
t148ff38s9h	2	7	due	due	ADP
t148ff38s9h	2	8	to	to	ADP
t148ff38s9h	2	9	problematic	problematic	ADJ
t148ff38s9h	2	10	side	side	NOUN
t148ff38s9h	2	11	effects	effect	NOUN
t148ff38s9h	2	12	including	include	VERB
t148ff38s9h	2	13	off	off	ADP
t148ff38s9h	2	14	-	-	PUNCT
t148ff38s9h	2	15	target	target	NOUN
t148ff38s9h	2	16	toxicity	toxicity	NOUN
t148ff38s9h	2	17	and	and	CCONJ
t148ff38s9h	2	18	the	the	DET
t148ff38s9h	2	19	development	development	NOUN
t148ff38s9h	2	20	of	of	ADP
t148ff38s9h	2	21	resistance	resistance	NOUN
t148ff38s9h	2	22	mechanisms	mechanism	NOUN
t148ff38s9h	2	23	.	.	PUNCT
t148ff38s9h	3	1	one	one	NUM
t148ff38s9h	3	2	such	such	ADJ
t148ff38s9h	3	3	strategy	strategy	NOUN
t148ff38s9h	3	4	to	to	PART
t148ff38s9h	3	5	overcome	overcome	VERB
t148ff38s9h	3	6	these	these	DET
t148ff38s9h	3	7	limitations	limitation	NOUN
t148ff38s9h	3	8	that	that	PRON
t148ff38s9h	3	9	has	have	AUX
t148ff38s9h	3	10	been	be	AUX
t148ff38s9h	3	11	implemented	implement	VERB
t148ff38s9h	3	12	involves	involve	VERB
t148ff38s9h	3	13	targeting	target	VERB
t148ff38s9h	3	14	multiple	multiple	ADJ
t148ff38s9h	3	15	sites	site	NOUN
t148ff38s9h	3	16	within	within	ADP
t148ff38s9h	3	17	cancer	cancer	NOUN
t148ff38s9h	3	18	cells	cell	NOUN
t148ff38s9h	3	19	.	.	PUNCT
t148ff38s9h	4	1	this	this	DET
t148ff38s9h	4	2	thesis	thesis	NOUN
t148ff38s9h	4	3	discusses	discuss	VERB
t148ff38s9h	4	4	projects	project	NOUN
t148ff38s9h	4	5	that	that	PRON
t148ff38s9h	4	6	contribute	contribute	VERB
t148ff38s9h	4	7	to	to	ADP
t148ff38s9h	4	8	the	the	DET
t148ff38s9h	4	9	development	development	NOUN
t148ff38s9h	4	10	of	of	ADP
t148ff38s9h	4	11	more	more	ADV
t148ff38s9h	4	12	beneficial	beneficial	ADJ
t148ff38s9h	4	13	cancer	cancer	NOUN
t148ff38s9h	4	14	therapeutics	therapeutic	NOUN
t148ff38s9h	4	15	using	use	VERB
t148ff38s9h	4	16	this	this	DET
t148ff38s9h	4	17	approach.apicularen	approach.apicularen	PROPN
t148ff38s9h	4	18	a	a	PRON
t148ff38s9h	4	19	is	be	AUX
t148ff38s9h	4	20	a	a	DET
t148ff38s9h	4	21	polyketide	polyketide	NOUN
t148ff38s9h	4	22	natural	natural	ADJ
t148ff38s9h	4	23	product	product	NOUN
t148ff38s9h	4	24	that	that	PRON
t148ff38s9h	4	25	has	have	AUX
t148ff38s9h	4	26	been	be	AUX
t148ff38s9h	4	27	shown	show	VERB
t148ff38s9h	4	28	to	to	PART
t148ff38s9h	4	29	act	act	VERB
t148ff38s9h	4	30	as	as	ADP
t148ff38s9h	4	31	an	an	DET
t148ff38s9h	4	32	inhibitor	inhibitor	NOUN
t148ff38s9h	4	33	of	of	ADP
t148ff38s9h	4	34	the	the	DET
t148ff38s9h	4	35	v	v	ADJ
t148ff38s9h	4	36	-	-	PUNCT
t148ff38s9h	4	37	atpase	atpase	ADJ
t148ff38s9h	4	38	enzyme	enzyme	NOUN
t148ff38s9h	4	39	.	.	PUNCT
t148ff38s9h	5	1	this	this	DET
t148ff38s9h	5	2	enzyme	enzyme	NOUN
t148ff38s9h	5	3	plays	play	VERB
t148ff38s9h	5	4	a	a	DET
t148ff38s9h	5	5	critical	critical	ADJ
t148ff38s9h	5	6	role	role	NOUN
t148ff38s9h	5	7	in	in	ADP
t148ff38s9h	5	8	maintaining	maintain	VERB
t148ff38s9h	5	9	the	the	DET
t148ff38s9h	5	10	homeostasis	homeostasis	NOUN
t148ff38s9h	5	11	of	of	ADP
t148ff38s9h	5	12	the	the	DET
t148ff38s9h	5	13	ph	ph	NOUN
t148ff38s9h	5	14	within	within	ADP
t148ff38s9h	5	15	a	a	DET
t148ff38s9h	5	16	cell	cell	NOUN
t148ff38s9h	5	17	.	.	PUNCT
t148ff38s9h	6	1	up	up	ADP
t148ff38s9h	6	2	-	-	PUNCT
t148ff38s9h	6	3	regulation	regulation	NOUN
t148ff38s9h	6	4	of	of	ADP
t148ff38s9h	6	5	this	this	DET
t148ff38s9h	6	6	enzyme	enzyme	NOUN
t148ff38s9h	6	7	has	have	AUX
t148ff38s9h	6	8	been	be	AUX
t148ff38s9h	6	9	observed	observe	VERB
t148ff38s9h	6	10	in	in	ADP
t148ff38s9h	6	11	cancer	cancer	NOUN
t148ff38s9h	6	12	cells	cell	NOUN
t148ff38s9h	6	13	.	.	PUNCT
t148ff38s9h	7	1	we	we	PRON
t148ff38s9h	7	2	have	have	AUX
t148ff38s9h	7	3	developed	develop	VERB
t148ff38s9h	7	4	a	a	DET
t148ff38s9h	7	5	formal	formal	ADJ
t148ff38s9h	7	6	synthesis	synthesis	NOUN
t148ff38s9h	7	7	of	of	ADP
t148ff38s9h	7	8	apicularen	apicularen	PROPN
t148ff38s9h	7	9	a	a	PRON
t148ff38s9h	7	10	,	,	PUNCT
t148ff38s9h	7	11	incorporating	incorporate	VERB
t148ff38s9h	7	12	our	our	PRON
t148ff38s9h	7	13	ether	ether	NOUN
t148ff38s9h	7	14	transfer	transfer	NOUN
t148ff38s9h	7	15	methodology	methodology	NOUN
t148ff38s9h	7	16	and	and	CCONJ
t148ff38s9h	7	17	diels	diel	NOUN
t148ff38s9h	7	18	-	-	PUNCT
t148ff38s9h	7	19	alder	alder	ADJ
t148ff38s9h	7	20	chemistry	chemistry	NOUN
t148ff38s9h	7	21	to	to	PART
t148ff38s9h	7	22	produce	produce	VERB
t148ff38s9h	7	23	the	the	DET
t148ff38s9h	7	24	macrolactone	macrolactone	NOUN
t148ff38s9h	7	25	of	of	ADP
t148ff38s9h	7	26	the	the	DET
t148ff38s9h	7	27	natural	natural	ADJ
t148ff38s9h	7	28	product	product	NOUN
t148ff38s9h	7	29	.	.	PUNCT
t148ff38s9h	8	1	this	this	DET
t148ff38s9h	8	2	synthetic	synthetic	ADJ
t148ff38s9h	8	3	route	route	NOUN
t148ff38s9h	8	4	can	can	AUX
t148ff38s9h	8	5	be	be	AUX
t148ff38s9h	8	6	applied	apply	VERB
t148ff38s9h	8	7	to	to	ADP
t148ff38s9h	8	8	the	the	DET
t148ff38s9h	8	9	synthesis	synthesis	NOUN
t148ff38s9h	8	10	of	of	ADP
t148ff38s9h	8	11	a	a	DET
t148ff38s9h	8	12	chimera	chimera	NOUN
t148ff38s9h	8	13	that	that	PRON
t148ff38s9h	8	14	consists	consist	VERB
t148ff38s9h	8	15	of	of	ADP
t148ff38s9h	8	16	the	the	DET
t148ff38s9h	8	17	apicularen	apicularen	NOUN
t148ff38s9h	8	18	a	a	DET
t148ff38s9h	8	19	macrolactone	macrolactone	NOUN
t148ff38s9h	8	20	and	and	CCONJ
t148ff38s9h	8	21	the	the	DET
t148ff38s9h	8	22	side	side	NOUN
t148ff38s9h	8	23	chain	chain	NOUN
t148ff38s9h	8	24	of	of	ADP
t148ff38s9h	8	25	cruentaren	cruentaren	PROPN
t148ff38s9h	8	26	a	a	PROPN
t148ff38s9h	8	27	,	,	PUNCT
t148ff38s9h	8	28	an	an	DET
t148ff38s9h	8	29	f	f	X
t148ff38s9h	8	30	-	-	PUNCT
t148ff38s9h	8	31	atpase	atpase	ADJ
t148ff38s9h	8	32	inhibitor	inhibitor	NOUN
t148ff38s9h	8	33	.	.	PUNCT
t148ff38s9h	9	1	the	the	DET
t148ff38s9h	9	2	addition	addition	NOUN
t148ff38s9h	9	3	of	of	ADP
t148ff38s9h	9	4	the	the	DET
t148ff38s9h	9	5	cruentaren	cruentaren	PROPN
t148ff38s9h	9	6	a	a	DET
t148ff38s9h	9	7	side	side	NOUN
t148ff38s9h	9	8	chain	chain	NOUN
t148ff38s9h	9	9	to	to	PART
t148ff38s9h	9	10	create	create	VERB
t148ff38s9h	9	11	a	a	DET
t148ff38s9h	9	12	chimeric	chimeric	ADJ
t148ff38s9h	9	13	analogue	analogue	NOUN
t148ff38s9h	9	14	was	be	AUX
t148ff38s9h	9	15	envisioned	envision	VERB
t148ff38s9h	9	16	to	to	PART
t148ff38s9h	9	17	shift	shift	VERB
t148ff38s9h	9	18	the	the	DET
t148ff38s9h	9	19	selectivity	selectivity	NOUN
t148ff38s9h	9	20	of	of	ADP
t148ff38s9h	9	21	apicularen	apicularen	NOUN
t148ff38s9h	9	22	a	a	PRON
t148ff38s9h	9	23	to	to	ADP
t148ff38s9h	9	24	a	a	DET
t148ff38s9h	9	25	dual	dual	ADJ
t148ff38s9h	9	26	-	-	PUNCT
t148ff38s9h	9	27	target	target	NOUN
t148ff38s9h	9	28	drug	drug	NOUN
t148ff38s9h	9	29	,	,	PUNCT
t148ff38s9h	9	30	both	both	PRON
t148ff38s9h	9	31	a	a	DET
t148ff38s9h	9	32	vand	vand	PROPN
t148ff38s9h	9	33	an	an	DET
t148ff38s9h	9	34	f	f	X
t148ff38s9h	9	35	-	-	PUNCT
t148ff38s9h	9	36	atpase	atpase	ADJ
t148ff38s9h	9	37	inhibitor	inhibitor	NOUN
t148ff38s9h	9	38	.	.	PUNCT
t148ff38s9h	10	1	the	the	DET
t148ff38s9h	10	2	ability	ability	NOUN
t148ff38s9h	10	3	of	of	ADP
t148ff38s9h	10	4	a	a	DET
t148ff38s9h	10	5	drug	drug	NOUN
t148ff38s9h	10	6	to	to	PART
t148ff38s9h	10	7	influence	influence	VERB
t148ff38s9h	10	8	different	different	ADJ
t148ff38s9h	10	9	components	component	NOUN
t148ff38s9h	10	10	of	of	ADP
t148ff38s9h	10	11	a	a	DET
t148ff38s9h	10	12	cell	cell	NOUN
t148ff38s9h	10	13	limits	limit	VERB
t148ff38s9h	10	14	the	the	DET
t148ff38s9h	10	15	cancer	cancer	NOUN
t148ff38s9h	10	16	cell	cell	NOUN
t148ff38s9h	10	17	's	's	PART
t148ff38s9h	10	18	propensity	propensity	NOUN
t148ff38s9h	10	19	to	to	PART
t148ff38s9h	10	20	develop	develop	VERB
t148ff38s9h	10	21	resistance	resistance	NOUN
t148ff38s9h	10	22	to	to	ADP
t148ff38s9h	10	23	the	the	DET
t148ff38s9h	10	24	compound	compound	NOUN
t148ff38s9h	10	25	.	.	PUNCT
t148ff38s9h	11	1	therefore	therefore	ADV
t148ff38s9h	11	2	,	,	PUNCT
t148ff38s9h	11	3	this	this	DET
t148ff38s9h	11	4	chimeric	chimeric	ADJ
t148ff38s9h	11	5	analogue	analogue	NOUN
t148ff38s9h	11	6	could	could	AUX
t148ff38s9h	11	7	lead	lead	VERB
t148ff38s9h	11	8	to	to	ADP
t148ff38s9h	11	9	more	more	ADV
t148ff38s9h	11	10	effective	effective	ADJ
t148ff38s9h	11	11	treatment	treatment	NOUN
t148ff38s9h	11	12	than	than	ADP
t148ff38s9h	11	13	the	the	DET
t148ff38s9h	11	14	parent	parent	NOUN
t148ff38s9h	11	15	compound	compound	NOUN
t148ff38s9h	11	16	.	.	PUNCT
t148ff38s9h	12	1	natural	natural	ADJ
t148ff38s9h	12	2	products	product	NOUN
t148ff38s9h	12	3	such	such	ADJ
t148ff38s9h	12	4	as	as	ADP
t148ff38s9h	12	5	paclitaxel	paclitaxel	PROPN
t148ff38s9h	12	6	(	(	PUNCT
t148ff38s9h	12	7	taxol	taxol	PROPN
t148ff38s9h	12	8	®	®	PROPN
t148ff38s9h	12	9	)	)	PUNCT
t148ff38s9h	12	10	and	and	CCONJ
t148ff38s9h	12	11	the	the	DET
t148ff38s9h	12	12	epothilone	epothilone	PROPN
t148ff38s9h	12	13	analogue	analogue	PROPN
t148ff38s9h	12	14	ixempra	ixempra	PROPN
t148ff38s9h	12	15	®	®	PROPN
t148ff38s9h	12	16	are	be	AUX
t148ff38s9h	12	17	microtubule	microtubule	NOUN
t148ff38s9h	12	18	stabilizing	stabilize	VERB
t148ff38s9h	12	19	agents	agent	NOUN
t148ff38s9h	12	20	that	that	PRON
t148ff38s9h	12	21	are	be	AUX
t148ff38s9h	12	22	used	use	VERB
t148ff38s9h	12	23	for	for	ADP
t148ff38s9h	12	24	the	the	DET
t148ff38s9h	12	25	treatment	treatment	NOUN
t148ff38s9h	12	26	of	of	ADP
t148ff38s9h	12	27	various	various	ADJ
t148ff38s9h	12	28	cancers	cancer	NOUN
t148ff38s9h	12	29	.	.	PUNCT
t148ff38s9h	13	1	we	we	PRON
t148ff38s9h	13	2	have	have	AUX
t148ff38s9h	13	3	been	be	AUX
t148ff38s9h	13	4	interested	interested	ADJ
t148ff38s9h	13	5	in	in	ADP
t148ff38s9h	13	6	the	the	DET
t148ff38s9h	13	7	conformational	conformational	ADJ
t148ff38s9h	13	8	profile	profile	NOUN
t148ff38s9h	13	9	of	of	ADP
t148ff38s9h	13	10	the	the	DET
t148ff38s9h	13	11	epothilones	epothilone	NOUN
t148ff38s9h	13	12	in	in	ADP
t148ff38s9h	13	13	relation	relation	NOUN
t148ff38s9h	13	14	to	to	ADP
t148ff38s9h	13	15	their	their	PRON
t148ff38s9h	13	16	activity	activity	NOUN
t148ff38s9h	13	17	.	.	PUNCT
t148ff38s9h	14	1	our	our	PRON
t148ff38s9h	14	2	group	group	NOUN
t148ff38s9h	14	3	has	have	AUX
t148ff38s9h	14	4	previously	previously	ADV
t148ff38s9h	14	5	published	publish	VERB
t148ff38s9h	14	6	the	the	DET
t148ff38s9h	14	7	major	major	ADJ
t148ff38s9h	14	8	conformational	conformational	ADJ
t148ff38s9h	14	9	profiles	profile	NOUN
t148ff38s9h	14	10	of	of	ADP
t148ff38s9h	14	11	this	this	DET
t148ff38s9h	14	12	class	class	NOUN
t148ff38s9h	14	13	of	of	ADP
t148ff38s9h	14	14	natural	natural	ADJ
t148ff38s9h	14	15	products	product	NOUN
t148ff38s9h	14	16	.	.	PUNCT
t148ff38s9h	15	1	in	in	ADP
t148ff38s9h	15	2	the	the	DET
t148ff38s9h	15	3	second	second	ADJ
t148ff38s9h	15	4	part	part	NOUN
t148ff38s9h	15	5	of	of	ADP
t148ff38s9h	15	6	this	this	DET
t148ff38s9h	15	7	thesis	thesis	NOUN
t148ff38s9h	15	8	we	we	PRON
t148ff38s9h	15	9	have	have	AUX
t148ff38s9h	15	10	synthesized	synthesize	VERB
t148ff38s9h	15	11	two	two	NUM
t148ff38s9h	15	12	novel	novel	ADJ
t148ff38s9h	15	13	epothilone	epothilone	NOUN
t148ff38s9h	15	14	analogues	analogue	NOUN
t148ff38s9h	15	15	that	that	PRON
t148ff38s9h	15	16	are	be	AUX
t148ff38s9h	15	17	designed	design	VERB
t148ff38s9h	15	18	to	to	PART
t148ff38s9h	15	19	assess	assess	VERB
t148ff38s9h	15	20	the	the	DET
t148ff38s9h	15	21	importance	importance	NOUN
t148ff38s9h	15	22	of	of	ADP
t148ff38s9h	15	23	the	the	DET
t148ff38s9h	15	24	c7oh	c7oh	NUM
t148ff38s9h	15	25	moiety	moiety	NOUN
t148ff38s9h	15	26	in	in	ADP
t148ff38s9h	15	27	the	the	DET
t148ff38s9h	15	28	molecule	molecule	NOUN
t148ff38s9h	15	29	's	's	PART
t148ff38s9h	15	30	activity	activity	NOUN
t148ff38s9h	15	31	profile	profile	NOUN
t148ff38s9h	15	32	.	.	PUNCT
t148ff38s9h	16	1	our	our	PRON
t148ff38s9h	16	2	conformational	conformational	ADJ
t148ff38s9h	16	3	profiles	profile	NOUN
t148ff38s9h	16	4	suggest	suggest	VERB
t148ff38s9h	16	5	that	that	SCONJ
t148ff38s9h	16	6	removal	removal	NOUN
t148ff38s9h	16	7	of	of	ADP
t148ff38s9h	16	8	this	this	DET
t148ff38s9h	16	9	functionality	functionality	NOUN
t148ff38s9h	16	10	will	will	AUX
t148ff38s9h	16	11	minimize	minimize	VERB
t148ff38s9h	16	12	the	the	DET
t148ff38s9h	16	13	inactive	inactive	ADJ
t148ff38s9h	16	14	conformation	conformation	NOUN
t148ff38s9h	16	15	,	,	PUNCT
t148ff38s9h	16	16	resulting	result	VERB
t148ff38s9h	16	17	in	in	ADP
t148ff38s9h	16	18	a	a	DET
t148ff38s9h	16	19	more	more	ADV
t148ff38s9h	16	20	active	active	ADJ
t148ff38s9h	16	21	compound	compound	NOUN
t148ff38s9h	16	22	.	.	PUNCT
t148ff38s9h	17	1	the	the	DET
t148ff38s9h	17	2	synthesis	synthesis	NOUN
t148ff38s9h	17	3	of	of	ADP
t148ff38s9h	17	4	the	the	DET
t148ff38s9h	17	5	analogues	analogue	NOUN
t148ff38s9h	17	6	without	without	ADP
t148ff38s9h	17	7	the	the	DET
t148ff38s9h	17	8	c7oh	c7oh	NOUN
t148ff38s9h	17	9	is	be	AUX
t148ff38s9h	17	10	carried	carry	VERB
t148ff38s9h	17	11	out	out	ADP
t148ff38s9h	17	12	and	and	CCONJ
t148ff38s9h	17	13	their	their	PRON
t148ff38s9h	17	14	activity	activity	NOUN
t148ff38s9h	17	15	in	in	ADP
t148ff38s9h	17	16	cancer	cancer	NOUN
t148ff38s9h	17	17	cells	cell	NOUN
t148ff38s9h	17	18	was	be	AUX
t148ff38s9h	17	19	determined	determine	VERB
t148ff38s9h	17	20	.	.	PUNCT
t148ff38s9h	18	1	the	the	DET
t148ff38s9h	18	2	results	result	NOUN
t148ff38s9h	18	3	showed	show	VERB
t148ff38s9h	18	4	that	that	SCONJ
t148ff38s9h	18	5	while	while	SCONJ
t148ff38s9h	18	6	conformation	conformation	NOUN
t148ff38s9h	18	7	is	be	AUX
t148ff38s9h	18	8	important	important	ADJ
t148ff38s9h	18	9	for	for	SCONJ
t148ff38s9h	18	10	the	the	DET
t148ff38s9h	18	11	design	design	NOUN
t148ff38s9h	18	12	of	of	ADP
t148ff38s9h	18	13	analogues	analogue	NOUN
t148ff38s9h	18	14	,	,	PUNCT
t148ff38s9h	18	15	key	key	ADJ
t148ff38s9h	18	16	intermolecular	intermolecular	ADJ
t148ff38s9h	18	17	bonding	bonding	NOUN
t148ff38s9h	18	18	within	within	ADP
t148ff38s9h	18	19	the	the	DET
t148ff38s9h	18	20	target	target	NOUN
t148ff38s9h	18	21	site	site	NOUN
t148ff38s9h	18	22	can	can	AUX
t148ff38s9h	18	23	override	override	VERB
t148ff38s9h	18	24	these	these	PRON
t148ff38s9h	18	25	preferences.the	preferences.the	DET
t148ff38s9h	18	26	last	last	ADJ
t148ff38s9h	18	27	project	project	NOUN
t148ff38s9h	18	28	investigates	investigate	VERB
t148ff38s9h	18	29	the	the	DET
t148ff38s9h	18	30	use	use	NOUN
t148ff38s9h	18	31	of	of	ADP
t148ff38s9h	18	32	the	the	DET
t148ff38s9h	18	33	epothilones	epothilone	NOUN
t148ff38s9h	18	34	in	in	ADP
t148ff38s9h	18	35	a	a	DET
t148ff38s9h	18	36	combination	combination	NOUN
t148ff38s9h	18	37	treatment	treatment	NOUN
t148ff38s9h	18	38	.	.	PUNCT
t148ff38s9h	19	1	subtle	subtle	ADJ
t148ff38s9h	19	2	differences	difference	NOUN
t148ff38s9h	19	3	in	in	ADP
t148ff38s9h	19	4	the	the	DET
t148ff38s9h	19	5	role	role	NOUN
t148ff38s9h	19	6	of	of	ADP
t148ff38s9h	19	7	microtubules	microtubule	NOUN
t148ff38s9h	19	8	during	during	ADP
t148ff38s9h	19	9	the	the	DET
t148ff38s9h	19	10	cell	cell	NOUN
t148ff38s9h	19	11	cycle	cycle	NOUN
t148ff38s9h	19	12	can	can	AUX
t148ff38s9h	19	13	provide	provide	VERB
t148ff38s9h	19	14	an	an	DET
t148ff38s9h	19	15	opportunity	opportunity	NOUN
t148ff38s9h	19	16	to	to	PART
t148ff38s9h	19	17	increase	increase	VERB
t148ff38s9h	19	18	the	the	DET
t148ff38s9h	19	19	susceptibility	susceptibility	NOUN
t148ff38s9h	19	20	of	of	ADP
t148ff38s9h	19	21	specific	specific	ADJ
t148ff38s9h	19	22	protein	protein	NOUN
t148ff38s9h	19	23	targets	target	NOUN
t148ff38s9h	19	24	.	.	PUNCT
t148ff38s9h	20	1	we	we	PRON
t148ff38s9h	20	2	have	have	AUX
t148ff38s9h	20	3	shown	show	VERB
t148ff38s9h	20	4	using	using	AUX
t148ff38s9h	20	5	fixed	fix	VERB
t148ff38s9h	20	6	and	and	CCONJ
t148ff38s9h	20	7	live	live	ADJ
t148ff38s9h	20	8	cell	cell	NOUN
t148ff38s9h	20	9	imaging	image	VERB
t148ff38s9h	20	10	that	that	SCONJ
t148ff38s9h	20	11	the	the	DET
t148ff38s9h	20	12	combination	combination	NOUN
t148ff38s9h	20	13	of	of	ADP
t148ff38s9h	20	14	epothilone	epothilone	NOUN
t148ff38s9h	20	15	and	and	CCONJ
t148ff38s9h	20	16	the	the	DET
t148ff38s9h	20	17	aurora	aurora	PROPN
t148ff38s9h	20	18	kinase	kinase	PROPN
t148ff38s9h	20	19	inhibitor	inhibitor	PROPN
t148ff38s9h	20	20	zm447439	zm447439	PROPN
t148ff38s9h	20	21	leads	lead	VERB
t148ff38s9h	20	22	to	to	ADP
t148ff38s9h	20	23	a	a	DET
t148ff38s9h	20	24	highly	highly	ADV
t148ff38s9h	20	25	penetrant	penetrant	ADJ
t148ff38s9h	20	26	mitotic	mitotic	ADJ
t148ff38s9h	20	27	defect	defect	NOUN
t148ff38s9h	20	28	that	that	PRON
t148ff38s9h	20	29	was	be	AUX
t148ff38s9h	20	30	distinct	distinct	ADJ
t148ff38s9h	20	31	from	from	ADP
t148ff38s9h	20	32	the	the	DET
t148ff38s9h	20	33	observed	observed	ADJ
t148ff38s9h	20	34	phenotype	phenotype	NOUN
t148ff38s9h	20	35	in	in	ADP
t148ff38s9h	20	36	individual	individual	ADJ
t148ff38s9h	20	37	treatment	treatment	NOUN
t148ff38s9h	20	38	.	.	PUNCT
t148ff38s9h	21	1	this	this	DET
t148ff38s9h	21	2	novel	novel	ADJ
t148ff38s9h	21	3	mechanism	mechanism	NOUN
t148ff38s9h	21	4	of	of	ADP
t148ff38s9h	21	5	cell	cell	NOUN
t148ff38s9h	21	6	death	death	NOUN
t148ff38s9h	21	7	is	be	AUX
t148ff38s9h	21	8	further	far	ADV
t148ff38s9h	21	9	investigated	investigate	VERB
t148ff38s9h	21	10	by	by	ADP
t148ff38s9h	21	11	the	the	DET
t148ff38s9h	21	12	synthesis	synthesis	NOUN
t148ff38s9h	21	13	of	of	ADP
t148ff38s9h	21	14	an	an	DET
t148ff38s9h	21	15	epothilone	epothilone	NOUN
t148ff38s9h	21	16	–	–	PUNCT
t148ff38s9h	21	17	aurora	aurora	PROPN
t148ff38s9h	21	18	kinase	kinase	PROPN
t148ff38s9h	21	19	inhibitor	inhibitor	NOUN
t148ff38s9h	21	20	conjugate	conjugate	NOUN
t148ff38s9h	21	21	.	.	PUNCT
t148ff38s9h	22	1	covalently	covalently	ADV
t148ff38s9h	22	2	combining	combine	VERB
t148ff38s9h	22	3	these	these	DET
t148ff38s9h	22	4	drugs	drug	NOUN
t148ff38s9h	22	5	has	have	VERB
t148ff38s9h	22	6	two	two	NUM
t148ff38s9h	22	7	main	main	ADJ
t148ff38s9h	22	8	advantages	advantage	NOUN
t148ff38s9h	22	9	:	:	PUNCT
t148ff38s9h	22	10	ensuring	ensure	VERB
t148ff38s9h	22	11	each	each	DET
t148ff38s9h	22	12	cell	cell	NOUN
t148ff38s9h	22	13	is	be	AUX
t148ff38s9h	22	14	delivered	deliver	VERB
t148ff38s9h	22	15	both	both	DET
t148ff38s9h	22	16	compounds	compound	NOUN
t148ff38s9h	22	17	for	for	ADP
t148ff38s9h	22	18	the	the	DET
t148ff38s9h	22	19	novel	novel	ADJ
t148ff38s9h	22	20	effect	effect	NOUN
t148ff38s9h	22	21	,	,	PUNCT
t148ff38s9h	22	22	and	and	CCONJ
t148ff38s9h	22	23	driving	drive	VERB
t148ff38s9h	22	24	the	the	DET
t148ff38s9h	22	25	aurora	aurora	NOUN
t148ff38s9h	22	26	kinase	kinase	NOUN
t148ff38s9h	22	27	inhibitor	inhibitor	NOUN
t148ff38s9h	22	28	into	into	ADP
t148ff38s9h	22	29	the	the	DET
t148ff38s9h	22	30	cell	cell	NOUN
t148ff38s9h	22	31	by	by	ADP
t148ff38s9h	22	32	utilizing	utilize	VERB
t148ff38s9h	22	33	the	the	DET
t148ff38s9h	22	34	known	know	VERB
t148ff38s9h	22	35	effect	effect	NOUN
t148ff38s9h	22	36	of	of	ADP
t148ff38s9h	22	37	high	high	ADJ
t148ff38s9h	22	38	accumulation	accumulation	NOUN
t148ff38s9h	22	39	of	of	ADP
t148ff38s9h	22	40	epothilones	epothilone	NOUN
t148ff38s9h	22	41	within	within	ADP
t148ff38s9h	22	42	the	the	DET
t148ff38s9h	22	43	cells	cell	NOUN
t148ff38s9h	22	44	.	.	PUNCT
t148ff38s9h	23	1	our	our	PRON
t148ff38s9h	23	2	synthesized	synthesized	ADJ
t148ff38s9h	23	3	conjugate	conjugate	NOUN
t148ff38s9h	23	4	was	be	AUX
t148ff38s9h	23	5	shown	show	VERB
t148ff38s9h	23	6	to	to	PART
t148ff38s9h	23	7	exhibit	exhibit	VERB
t148ff38s9h	23	8	nanomolar	nanomolar	ADJ
t148ff38s9h	23	9	activity	activity	NOUN
t148ff38s9h	23	10	.	.	PUNCT
t148ff38s9h	24	1	together	together	ADV
t148ff38s9h	24	2	the	the	DET
t148ff38s9h	24	3	projects	project	NOUN
t148ff38s9h	24	4	described	describe	VERB
t148ff38s9h	24	5	in	in	ADP
t148ff38s9h	24	6	this	this	DET
t148ff38s9h	24	7	thesis	thesis	NOUN
t148ff38s9h	24	8	demonstrate	demonstrate	VERB
t148ff38s9h	24	9	that	that	SCONJ
t148ff38s9h	24	10	both	both	CCONJ
t148ff38s9h	24	11	enzymatic	enzymatic	ADJ
t148ff38s9h	24	12	and	and	CCONJ
t148ff38s9h	24	13	structural	structural	ADJ
t148ff38s9h	24	14	components	component	NOUN
t148ff38s9h	24	15	of	of	ADP
t148ff38s9h	24	16	the	the	DET
t148ff38s9h	24	17	cell	cell	NOUN
t148ff38s9h	24	18	can	can	AUX
t148ff38s9h	24	19	serve	serve	VERB
t148ff38s9h	24	20	as	as	ADP
t148ff38s9h	24	21	useful	useful	ADJ
t148ff38s9h	24	22	targets	target	NOUN
t148ff38s9h	24	23	for	for	ADP
t148ff38s9h	24	24	the	the	DET
t148ff38s9h	24	25	development	development	NOUN
t148ff38s9h	24	26	of	of	ADP
t148ff38s9h	24	27	cancer	cancer	NOUN
t148ff38s9h	24	28	therapeutics	therapeutic	NOUN
t148ff38s9h	24	29	.	.	PUNCT
t148ff38s9h	25	1	furthermore	furthermore	ADV
t148ff38s9h	25	2	,	,	PUNCT
t148ff38s9h	25	3	the	the	DET
t148ff38s9h	25	4	combination	combination	NOUN
t148ff38s9h	25	5	of	of	ADP
t148ff38s9h	25	6	known	know	VERB
t148ff38s9h	25	7	molecules	molecule	NOUN
t148ff38s9h	25	8	in	in	ADP
t148ff38s9h	25	9	different	different	ADJ
t148ff38s9h	25	10	ways	way	NOUN
t148ff38s9h	25	11	can	can	AUX
t148ff38s9h	25	12	lead	lead	VERB
t148ff38s9h	25	13	to	to	ADP
t148ff38s9h	25	14	novel	novel	ADJ
t148ff38s9h	25	15	therapeutics	therapeutic	NOUN
t148ff38s9h	25	16	with	with	ADP
t148ff38s9h	25	17	the	the	DET
t148ff38s9h	25	18	potential	potential	NOUN
t148ff38s9h	25	19	to	to	PART
t148ff38s9h	25	20	be	be	AUX
t148ff38s9h	25	21	more	more	ADV
t148ff38s9h	25	22	effective	effective	ADJ
t148ff38s9h	25	23	cancer	cancer	NOUN
t148ff38s9h	25	24	treatments	treatment	NOUN
t148ff38s9h	25	25	.	.	PUNCT