id sid tid token lemma pos sx61dj5618q 1 1 mycobacteria mycobacteria PROPN sx61dj5618q 1 2 tuberculosis tuberculosis NOUN sx61dj5618q 1 3 ( ( PUNCT sx61dj5618q 1 4 m.tb m.tb PROPN sx61dj5618q 1 5 ) ) PUNCT sx61dj5618q 1 6 , , PUNCT sx61dj5618q 1 7 the the DET sx61dj5618q 1 8 causative causative ADJ sx61dj5618q 1 9 agent agent NOUN sx61dj5618q 1 10 of of ADP sx61dj5618q 1 11 tb tb PROPN sx61dj5618q 1 12 , , PUNCT sx61dj5618q 1 13 although although SCONJ sx61dj5618q 1 14 largely largely ADV sx61dj5618q 1 15 a a DET sx61dj5618q 1 16 curable curable ADJ sx61dj5618q 1 17 disease disease NOUN sx61dj5618q 1 18 , , PUNCT sx61dj5618q 1 19 still still ADV sx61dj5618q 1 20 remains remain VERB sx61dj5618q 1 21 a a DET sx61dj5618q 1 22 major major ADJ sx61dj5618q 1 23 cause cause NOUN sx61dj5618q 1 24 of of ADP sx61dj5618q 1 25 morbidity morbidity NOUN sx61dj5618q 1 26 and and CCONJ sx61dj5618q 1 27 mortality mortality NOUN sx61dj5618q 1 28 worldwide worldwide ADV sx61dj5618q 1 29 , , PUNCT sx61dj5618q 1 30 resulting result VERB sx61dj5618q 1 31 in in ADP sx61dj5618q 1 32 approximately approximately ADV sx61dj5618q 1 33 1.5 1.5 NUM sx61dj5618q 1 34 million million NUM sx61dj5618q 1 35 deaths death NOUN sx61dj5618q 1 36 per per ADP sx61dj5618q 1 37 year year NOUN sx61dj5618q 1 38 . . PUNCT sx61dj5618q 2 1 a a DET sx61dj5618q 2 2 better well ADJ sx61dj5618q 2 3 understanding understanding NOUN sx61dj5618q 2 4 of of ADP sx61dj5618q 2 5 the the DET sx61dj5618q 2 6 host host NOUN sx61dj5618q 2 7 response response NOUN sx61dj5618q 2 8 to to ADP sx61dj5618q 2 9 m.tb m.tb PROPN sx61dj5618q 2 10 is be AUX sx61dj5618q 2 11 needed need VERB sx61dj5618q 2 12 to to PART sx61dj5618q 2 13 develop develop VERB sx61dj5618q 2 14 the the DET sx61dj5618q 2 15 next next ADJ sx61dj5618q 2 16 generation generation NOUN sx61dj5618q 2 17 of of ADP sx61dj5618q 2 18 therapeutics therapeutic NOUN sx61dj5618q 2 19 and and CCONJ sx61dj5618q 2 20 vaccines vaccine NOUN sx61dj5618q 2 21 . . PUNCT sx61dj5618q 3 1 the the DET sx61dj5618q 3 2 objective objective NOUN sx61dj5618q 3 3 of of ADP sx61dj5618q 3 4 this this DET sx61dj5618q 3 5 project project NOUN sx61dj5618q 3 6 centers center VERB sx61dj5618q 3 7 around around ADP sx61dj5618q 3 8 two two NUM sx61dj5618q 3 9 major major ADJ sx61dj5618q 3 10 aims aim NOUN sx61dj5618q 3 11 : : PUNCT sx61dj5618q 3 12 1 1 X sx61dj5618q 3 13 ) ) PUNCT sx61dj5618q 3 14 characterizing characterize VERB sx61dj5618q 3 15 the the DET sx61dj5618q 3 16 role role NOUN sx61dj5618q 3 17 of of ADP sx61dj5618q 3 18 arf6 arf6 PROPN sx61dj5618q 3 19 in in ADP sx61dj5618q 3 20 host host NOUN sx61dj5618q 3 21 signaling signal VERB sx61dj5618q 3 22 and and CCONJ sx61dj5618q 3 23 phagosome phagosome ADJ sx61dj5618q 3 24 - - PUNCT sx61dj5618q 3 25 lysosome lysosome NOUN sx61dj5618q 3 26 fusion fusion NOUN sx61dj5618q 3 27 in in ADP sx61dj5618q 3 28 macrophages macrophage NOUN sx61dj5618q 3 29 upon upon SCONJ sx61dj5618q 3 30 m.tb m.tb NOUN sx61dj5618q 3 31 infection infection NOUN sx61dj5618q 3 32 and and CCONJ sx61dj5618q 3 33 2 2 X sx61dj5618q 3 34 ) ) PUNCT sx61dj5618q 3 35 characterizing characterize VERB sx61dj5618q 3 36 both both CCONJ sx61dj5618q 3 37 composition composition NOUN sx61dj5618q 3 38 and and CCONJ sx61dj5618q 3 39 function function NOUN sx61dj5618q 3 40 of of ADP sx61dj5618q 3 41 microvesicles microvesicle NOUN sx61dj5618q 3 42 after after ADP sx61dj5618q 3 43 infection infection NOUN sx61dj5618q 3 44 . . PUNCT sx61dj5618q 4 1 previous previous ADJ sx61dj5618q 4 2 studies study NOUN sx61dj5618q 4 3 have have AUX sx61dj5618q 4 4 shown show VERB sx61dj5618q 4 5 that that SCONJ sx61dj5618q 4 6 m.tb m.tb PROPN sx61dj5618q 4 7 interferes interfere VERB sx61dj5618q 4 8 with with ADP sx61dj5618q 4 9 trafficking trafficking NOUN sx61dj5618q 4 10 by by ADP sx61dj5618q 4 11 preventing prevent VERB sx61dj5618q 4 12 phagosome phagosome ADJ sx61dj5618q 4 13 - - PUNCT sx61dj5618q 4 14 lysosome lysosome NOUN sx61dj5618q 4 15 fusion fusion NOUN sx61dj5618q 4 16 . . PUNCT sx61dj5618q 5 1 arf6 arf6 PROPN sx61dj5618q 5 2 , , PUNCT sx61dj5618q 5 3 a a DET sx61dj5618q 5 4 small small ADJ sx61dj5618q 5 5 gdp gdp NOUN sx61dj5618q 5 6 binding bind VERB sx61dj5618q 5 7 protein protein NOUN sx61dj5618q 5 8 , , PUNCT sx61dj5618q 5 9 is be AUX sx61dj5618q 5 10 involved involve VERB sx61dj5618q 5 11 in in ADP sx61dj5618q 5 12 regulating regulate VERB sx61dj5618q 5 13 various various ADJ sx61dj5618q 5 14 host host NOUN sx61dj5618q 5 15 - - PUNCT sx61dj5618q 5 16 signaling signal VERB sx61dj5618q 5 17 pathways pathway NOUN sx61dj5618q 5 18 as as ADV sx61dj5618q 5 19 well well ADV sx61dj5618q 5 20 as as ADP sx61dj5618q 5 21 functioning function VERB sx61dj5618q 5 22 in in ADP sx61dj5618q 5 23 promoting promote VERB sx61dj5618q 5 24 actin actin NOUN sx61dj5618q 5 25 cytoskeleton cytoskeleton NOUN sx61dj5618q 5 26 rearrangements rearrangement NOUN sx61dj5618q 5 27 and and CCONJ sx61dj5618q 5 28 membrane membrane NOUN sx61dj5618q 5 29 trafficking trafficking NOUN sx61dj5618q 5 30 . . PUNCT sx61dj5618q 6 1 therefore therefore ADV sx61dj5618q 6 2 , , PUNCT sx61dj5618q 6 3 this this DET sx61dj5618q 6 4 project project NOUN sx61dj5618q 6 5 focuses focus VERB sx61dj5618q 6 6 on on ADP sx61dj5618q 6 7 the the DET sx61dj5618q 6 8 biological biological ADJ sx61dj5618q 6 9 processes process NOUN sx61dj5618q 6 10 , , PUNCT sx61dj5618q 6 11 such such ADJ sx61dj5618q 6 12 as as ADP sx61dj5618q 6 13 secretion secretion NOUN sx61dj5618q 6 14 , , PUNCT sx61dj5618q 6 15 phagocytosis phagocytosis NOUN sx61dj5618q 6 16 , , PUNCT sx61dj5618q 6 17 and and CCONJ sx61dj5618q 6 18 cytokinesis cytokinesis NOUN sx61dj5618q 6 19 , , PUNCT sx61dj5618q 6 20 previously previously ADV sx61dj5618q 6 21 shown show VERB sx61dj5618q 6 22 in in ADP sx61dj5618q 6 23 the the DET sx61dj5618q 6 24 literature literature NOUN sx61dj5618q 6 25 , , PUNCT sx61dj5618q 6 26 to to PART sx61dj5618q 6 27 be be AUX sx61dj5618q 6 28 regulated regulate VERB sx61dj5618q 6 29 by by ADP sx61dj5618q 6 30 arf6 arf6 PROPN sx61dj5618q 6 31 and and CCONJ sx61dj5618q 6 32 also also ADV sx61dj5618q 6 33 necessary necessary ADJ sx61dj5618q 6 34 for for ADP sx61dj5618q 6 35 a a DET sx61dj5618q 6 36 successful successful ADJ sx61dj5618q 6 37 m.tb m.tb PROPN sx61dj5618q 6 38 infection infection NOUN sx61dj5618q 6 39 . . PUNCT sx61dj5618q 7 1 in in ADP sx61dj5618q 7 2 our our PRON sx61dj5618q 7 3 present present ADJ sx61dj5618q 7 4 studies study NOUN sx61dj5618q 7 5 we we PRON sx61dj5618q 7 6 have have AUX sx61dj5618q 7 7 determined determine VERB sx61dj5618q 7 8 that that SCONJ sx61dj5618q 7 9 arf6 arf6 PROPN sx61dj5618q 7 10 is be AUX sx61dj5618q 7 11 activated activate VERB sx61dj5618q 7 12 in in ADP sx61dj5618q 7 13 macrophages macrophage NOUN sx61dj5618q 7 14 following follow VERB sx61dj5618q 7 15 an an DET sx61dj5618q 7 16 infection infection NOUN sx61dj5618q 7 17 with with ADP sx61dj5618q 7 18 complement complement NOUN sx61dj5618q 7 19 opsonized opsonize VERB sx61dj5618q 7 20 m.tb m.tb PROPN sx61dj5618q 7 21 and and CCONJ sx61dj5618q 7 22 that that SCONJ sx61dj5618q 7 23 there there PRON sx61dj5618q 7 24 is be VERB sx61dj5618q 7 25 an an DET sx61dj5618q 7 26 accumulation accumulation NOUN sx61dj5618q 7 27 of of ADP sx61dj5618q 7 28 arf6 arf6 PROPN sx61dj5618q 7 29 with with ADP sx61dj5618q 7 30 the the DET sx61dj5618q 7 31 mycobacteria mycobacteria NOUN sx61dj5618q 7 32 containing contain VERB sx61dj5618q 7 33 phagosomes phagosome NOUN sx61dj5618q 7 34 . . PUNCT sx61dj5618q 8 1 interestingly interestingly ADV sx61dj5618q 8 2 , , PUNCT sx61dj5618q 8 3 we we PRON sx61dj5618q 8 4 showed show VERB sx61dj5618q 8 5 a a DET sx61dj5618q 8 6 diminished diminished ADJ sx61dj5618q 8 7 activation activation NOUN sx61dj5618q 8 8 of of ADP sx61dj5618q 8 9 erk erk PROPN sx61dj5618q 8 10 in in ADP sx61dj5618q 8 11 m.tb m.tb PROPN sx61dj5618q 8 12 infected infect VERB sx61dj5618q 8 13 macrophages macrophage NOUN sx61dj5618q 8 14 when when SCONJ sx61dj5618q 8 15 cells cell NOUN sx61dj5618q 8 16 expressed express VERB sx61dj5618q 8 17 an an DET sx61dj5618q 8 18 arf6 arf6 PROPN sx61dj5618q 8 19 mutant mutant NOUN sx61dj5618q 8 20 defective defective ADJ sx61dj5618q 8 21 in in ADP sx61dj5618q 8 22 gtp gtp NOUN sx61dj5618q 8 23 hydrolysis hydrolysis NOUN sx61dj5618q 8 24 ( ( PUNCT sx61dj5618q 8 25 q67l q67l ADV sx61dj5618q 8 26 ) ) PUNCT sx61dj5618q 8 27 . . PUNCT sx61dj5618q 9 1 however however ADV sx61dj5618q 9 2 , , PUNCT sx61dj5618q 9 3 this this DET sx61dj5618q 9 4 diminished diminished ADJ sx61dj5618q 9 5 activation activation NOUN sx61dj5618q 9 6 of of ADP sx61dj5618q 9 7 erk erk PROPN sx61dj5618q 9 8 did do AUX sx61dj5618q 9 9 not not PART sx61dj5618q 9 10 result result VERB sx61dj5618q 9 11 in in ADP sx61dj5618q 9 12 measurable measurable ADJ sx61dj5618q 9 13 differences difference NOUN sx61dj5618q 9 14 in in ADP sx61dj5618q 9 15 nf nf NOUN sx61dj5618q 9 16 - - PUNCT sx61dj5618q 9 17 ƙb ƙb INTJ sx61dj5618q 9 18 nuclear nuclear ADJ sx61dj5618q 9 19 localization localization NOUN sx61dj5618q 9 20 or or CCONJ sx61dj5618q 9 21 production production NOUN sx61dj5618q 9 22 of of ADP sx61dj5618q 9 23 various various ADJ sx61dj5618q 9 24 cytokines cytokine NOUN sx61dj5618q 9 25 including include VERB sx61dj5618q 9 26 tnf tnf PROPN sx61dj5618q 9 27 - - PROPN sx61dj5618q 9 28 α α PROPN sx61dj5618q 9 29 . . PUNCT sx61dj5618q 10 1 our our PRON sx61dj5618q 10 2 data datum NOUN sx61dj5618q 10 3 suggest suggest VERB sx61dj5618q 10 4 that that SCONJ sx61dj5618q 10 5 arf6 arf6 PROPN sx61dj5618q 10 6 is be AUX sx61dj5618q 10 7 not not PART sx61dj5618q 10 8 playing play VERB sx61dj5618q 10 9 a a DET sx61dj5618q 10 10 significant significant ADJ sx61dj5618q 10 11 role role NOUN sx61dj5618q 10 12 in in ADP sx61dj5618q 10 13 driving drive VERB sx61dj5618q 10 14 the the DET sx61dj5618q 10 15 pro pro ADJ sx61dj5618q 10 16 - - ADJ sx61dj5618q 10 17 inflammatory inflammatory ADJ sx61dj5618q 10 18 responses response NOUN sx61dj5618q 10 19 induced induce VERB sx61dj5618q 10 20 in in ADP sx61dj5618q 10 21 macrophages macrophage NOUN sx61dj5618q 10 22 upon upon SCONJ sx61dj5618q 10 23 an an DET sx61dj5618q 10 24 m.tb m.tb PROPN sx61dj5618q 10 25 infection infection NOUN sx61dj5618q 10 26 . . PUNCT sx61dj5618q 11 1 previous previous ADJ sx61dj5618q 11 2 work work NOUN sx61dj5618q 11 3 in in ADP sx61dj5618q 11 4 the the DET sx61dj5618q 11 5 laboratory laboratory NOUN sx61dj5618q 11 6 has have AUX sx61dj5618q 11 7 shown show VERB sx61dj5618q 11 8 that that SCONJ sx61dj5618q 11 9 there there PRON sx61dj5618q 11 10 are be VERB sx61dj5618q 11 11 mycobacterial mycobacterial ADJ sx61dj5618q 11 12 specific specific ADJ sx61dj5618q 11 13 proteins protein NOUN sx61dj5618q 11 14 present present ADJ sx61dj5618q 11 15 in in ADP sx61dj5618q 11 16 exosomes exosome NOUN sx61dj5618q 11 17 released release VERB sx61dj5618q 11 18 from from ADP sx61dj5618q 11 19 m.tb m.tb PROPN sx61dj5618q 11 20 - - PUNCT sx61dj5618q 11 21 infected infect VERB sx61dj5618q 11 22 cells cell NOUN sx61dj5618q 11 23 and and CCONJ sx61dj5618q 11 24 that that SCONJ sx61dj5618q 11 25 these these DET sx61dj5618q 11 26 exosomes exosome NOUN sx61dj5618q 11 27 have have VERB sx61dj5618q 11 28 a a DET sx61dj5618q 11 29 multi multi ADJ sx61dj5618q 11 30 - - ADJ sx61dj5618q 11 31 functional functional ADJ sx61dj5618q 11 32 immunological immunological ADJ sx61dj5618q 11 33 role role NOUN sx61dj5618q 11 34 . . PUNCT sx61dj5618q 12 1 further far ADV sx61dj5618q 12 2 , , PUNCT sx61dj5618q 12 3 it it PRON sx61dj5618q 12 4 has have AUX sx61dj5618q 12 5 been be AUX sx61dj5618q 12 6 shown show VERB sx61dj5618q 12 7 across across ADP sx61dj5618q 12 8 several several ADJ sx61dj5618q 12 9 infection infection NOUN sx61dj5618q 12 10 models model NOUN sx61dj5618q 12 11 ( ( PUNCT sx61dj5618q 12 12 i.e. i.e. X sx61dj5618q 12 13 tissue tissue NOUN sx61dj5618q 12 14 culture culture NOUN sx61dj5618q 12 15 infections infection NOUN sx61dj5618q 12 16 , , PUNCT sx61dj5618q 12 17 mouse mouse NOUN sx61dj5618q 12 18 infections infection NOUN sx61dj5618q 12 19 , , PUNCT sx61dj5618q 12 20 and and CCONJ sx61dj5618q 12 21 human human PROPN sx61dj5618q 12 22 m.tb m.tb PROPN sx61dj5618q 12 23 patient patient NOUN sx61dj5618q 12 24 ) ) PUNCT sx61dj5618q 12 25 that that SCONJ sx61dj5618q 12 26 several several ADJ sx61dj5618q 12 27 of of ADP sx61dj5618q 12 28 these these DET sx61dj5618q 12 29 proteins protein NOUN sx61dj5618q 12 30 are be AUX sx61dj5618q 12 31 conserved conserve VERB sx61dj5618q 12 32 , , PUNCT sx61dj5618q 12 33 suggesting suggest VERB sx61dj5618q 12 34 they they PRON sx61dj5618q 12 35 could could AUX sx61dj5618q 12 36 serve serve VERB sx61dj5618q 12 37 as as ADP sx61dj5618q 12 38 biomarkers biomarker NOUN sx61dj5618q 12 39 for for ADP sx61dj5618q 12 40 disease disease NOUN sx61dj5618q 12 41 . . PUNCT sx61dj5618q 13 1 exosomes exosome NOUN sx61dj5618q 13 2 have have AUX sx61dj5618q 13 3 been be AUX sx61dj5618q 13 4 well well ADV sx61dj5618q 13 5 characterized characterize VERB sx61dj5618q 13 6 in in ADP sx61dj5618q 13 7 the the DET sx61dj5618q 13 8 context context NOUN sx61dj5618q 13 9 of of ADP sx61dj5618q 13 10 mycobacterial mycobacterial ADJ sx61dj5618q 13 11 infection infection NOUN sx61dj5618q 13 12 ; ; PUNCT sx61dj5618q 13 13 however however ADV sx61dj5618q 13 14 , , PUNCT sx61dj5618q 13 15 macrophages macrophage NOUN sx61dj5618q 13 16 also also ADV sx61dj5618q 13 17 release release VERB sx61dj5618q 13 18 microvesicles microvesicle NOUN sx61dj5618q 13 19 , , PUNCT sx61dj5618q 13 20 which which PRON sx61dj5618q 13 21 are be AUX sx61dj5618q 13 22 derived derive VERB sx61dj5618q 13 23 from from ADP sx61dj5618q 13 24 the the DET sx61dj5618q 13 25 budding budding NOUN sx61dj5618q 13 26 of of ADP sx61dj5618q 13 27 the the DET sx61dj5618q 13 28 plasma plasma NOUN sx61dj5618q 13 29 membrane membrane NOUN sx61dj5618q 13 30 , , PUNCT sx61dj5618q 13 31 and and CCONJ sx61dj5618q 13 32 these these DET sx61dj5618q 13 33 vesicles vesicle NOUN sx61dj5618q 13 34 have have AUX sx61dj5618q 13 35 not not PART sx61dj5618q 13 36 been be AUX sx61dj5618q 13 37 characterized characterize VERB sx61dj5618q 13 38 in in ADP sx61dj5618q 13 39 this this DET sx61dj5618q 13 40 manner manner NOUN sx61dj5618q 13 41 . . PUNCT sx61dj5618q 14 1 our our PRON sx61dj5618q 14 2 findings finding NOUN sx61dj5618q 14 3 suggest suggest VERB sx61dj5618q 14 4 that that SCONJ sx61dj5618q 14 5 exosomes exosome NOUN sx61dj5618q 14 6 released release VERB sx61dj5618q 14 7 from from ADP sx61dj5618q 14 8 m.tb m.tb PROPN sx61dj5618q 14 9 infected infect VERB sx61dj5618q 14 10 macrophages macrophage NOUN sx61dj5618q 14 11 are be AUX sx61dj5618q 14 12 more more ADV sx61dj5618q 14 13 enriched enriched ADJ sx61dj5618q 14 14 in in ADP sx61dj5618q 14 15 mycobacterial mycobacterial ADJ sx61dj5618q 14 16 proteins protein NOUN sx61dj5618q 14 17 than than SCONJ sx61dj5618q 14 18 observed observe VERB sx61dj5618q 14 19 with with ADP sx61dj5618q 14 20 microvesicles microvesicle NOUN sx61dj5618q 14 21 released release VERB sx61dj5618q 14 22 from from ADP sx61dj5618q 14 23 the the DET sx61dj5618q 14 24 infected infected ADJ sx61dj5618q 14 25 cells cell NOUN sx61dj5618q 14 26 . . PUNCT sx61dj5618q 15 1 these these DET sx61dj5618q 15 2 studies study NOUN sx61dj5618q 15 3 also also ADV sx61dj5618q 15 4 suggest suggest VERB sx61dj5618q 15 5 that that SCONJ sx61dj5618q 15 6 this this DET sx61dj5618q 15 7 exosome exosome NOUN sx61dj5618q 15 8 population population NOUN sx61dj5618q 15 9 produces produce VERB sx61dj5618q 15 10 a a DET sx61dj5618q 15 11 more more ADV sx61dj5618q 15 12 robust robust ADJ sx61dj5618q 15 13 stimulation stimulation NOUN sx61dj5618q 15 14 of of ADP sx61dj5618q 15 15 macrophages macrophage NOUN sx61dj5618q 15 16 and and CCONJ sx61dj5618q 15 17 pre pre ADJ sx61dj5618q 15 18 - - ADJ sx61dj5618q 15 19 sensitized sensitize VERB sx61dj5618q 15 20 t t NOUN sx61dj5618q 15 21 - - PUNCT sx61dj5618q 15 22 cells cell NOUN sx61dj5618q 15 23 compared compare VERB sx61dj5618q 15 24 to to ADP sx61dj5618q 15 25 microvesicles microvesicle NOUN sx61dj5618q 15 26 . . PUNCT sx61dj5618q 16 1 altogether altogether ADV sx61dj5618q 16 2 , , PUNCT sx61dj5618q 16 3 our our PRON sx61dj5618q 16 4 data datum NOUN sx61dj5618q 16 5 support support VERB sx61dj5618q 16 6 a a DET sx61dj5618q 16 7 more more ADV sx61dj5618q 16 8 functional functional ADJ sx61dj5618q 16 9 role role NOUN sx61dj5618q 16 10 for for ADP sx61dj5618q 16 11 exosomes exosome NOUN sx61dj5618q 16 12 then then ADV sx61dj5618q 16 13 microvesicles microvesicle VERB sx61dj5618q 16 14 in in ADP sx61dj5618q 16 15 the the DET sx61dj5618q 16 16 pathobiology pathobiology NOUN sx61dj5618q 16 17 of of ADP sx61dj5618q 16 18 an an DET sx61dj5618q 16 19 m.tb m.tb PROPN sx61dj5618q 16 20 infection infection NOUN sx61dj5618q 16 21 . . PUNCT