id sid tid token lemma pos sq87br88s6n 1 1 many many ADJ sq87br88s6n 1 2 virulence virulence NOUN sq87br88s6n 1 3 factors factor NOUN sq87br88s6n 1 4 secreted secrete VERB sq87br88s6n 1 5 from from ADP sq87br88s6n 1 6 pathogenic pathogenic ADJ sq87br88s6n 1 7 gram gram ADJ sq87br88s6n 1 8 - - PUNCT sq87br88s6n 1 9 negative negative ADJ sq87br88s6n 1 10 bacteria bacteria NOUN sq87br88s6n 1 11 are be AUX sq87br88s6n 1 12 autotransporter autotransporter NOUN sq87br88s6n 1 13 proteins protein NOUN sq87br88s6n 1 14 . . PUNCT sq87br88s6n 2 1 the the DET sq87br88s6n 2 2 final final ADJ sq87br88s6n 2 3 step step NOUN sq87br88s6n 2 4 of of ADP sq87br88s6n 2 5 autotransporter autotransporter NOUN sq87br88s6n 2 6 secretion secretion NOUN sq87br88s6n 2 7 is be AUX sq87br88s6n 2 8 passage passage NOUN sq87br88s6n 2 9 across across ADP sq87br88s6n 2 10 the the DET sq87br88s6n 2 11 outer outer ADJ sq87br88s6n 2 12 membrane membrane NOUN sq87br88s6n 2 13 ( ( PUNCT sq87br88s6n 2 14 om om PROPN sq87br88s6n 2 15 ) ) PUNCT sq87br88s6n 2 16 , , PUNCT sq87br88s6n 2 17 mediated mediate VERB sq87br88s6n 2 18 by by ADP sq87br88s6n 2 19 a a DET sq87br88s6n 2 20 cotranslated cotranslate VERB sq87br88s6n 2 21 c c PROPN sq87br88s6n 2 22 - - PUNCT sq87br88s6n 2 23 terminal terminal NOUN sq87br88s6n 2 24 porin porin NOUN sq87br88s6n 2 25 domain domain NOUN sq87br88s6n 2 26 . . PUNCT sq87br88s6n 3 1 the the DET sq87br88s6n 3 2 native native ADJ sq87br88s6n 3 3 structure structure NOUN sq87br88s6n 3 4 is be AUX sq87br88s6n 3 5 formed form VERB sq87br88s6n 3 6 only only ADV sq87br88s6n 3 7 after after ADP sq87br88s6n 3 8 this this DET sq87br88s6n 3 9 final final ADJ sq87br88s6n 3 10 secretion secretion NOUN sq87br88s6n 3 11 step step NOUN sq87br88s6n 3 12 , , PUNCT sq87br88s6n 3 13 which which PRON sq87br88s6n 3 14 requires require VERB sq87br88s6n 3 15 neither neither CCONJ sq87br88s6n 3 16 atp atp VERB sq87br88s6n 3 17 nor nor CCONJ sq87br88s6n 3 18 a a DET sq87br88s6n 3 19 proton proton NOUN sq87br88s6n 3 20 gradient gradient NOUN sq87br88s6n 3 21 . . PUNCT sq87br88s6n 4 1 sequence sequence NOUN sq87br88s6n 4 2 analysis analysis NOUN sq87br88s6n 4 3 reveals reveal VERB sq87br88s6n 4 4 that that SCONJ sq87br88s6n 4 5 , , PUNCT sq87br88s6n 4 6 despite despite SCONJ sq87br88s6n 4 7 size size NOUN sq87br88s6n 4 8 , , PUNCT sq87br88s6n 4 9 sequence sequence NOUN sq87br88s6n 4 10 , , PUNCT sq87br88s6n 4 11 and and CCONJ sq87br88s6n 4 12 functional functional ADJ sq87br88s6n 4 13 diversity diversity NOUN sq87br88s6n 4 14 among among ADP sq87br88s6n 4 15 autotransporter autotransporter NOUN sq87br88s6n 4 16 passenger passenger NOUN sq87br88s6n 4 17 domains domain NOUN sq87br88s6n 4 18 , , PUNCT sq87br88s6n 4 19 > > X sq87br88s6n 4 20 97 97 NUM sq87br88s6n 4 21 % % NOUN sq87br88s6n 4 22 are be AUX sq87br88s6n 4 23 predicted predict VERB sq87br88s6n 4 24 to to PART sq87br88s6n 4 25 form form VERB sq87br88s6n 4 26 parallel parallel ADJ sq87br88s6n 4 27 ì_å_-helices ì_å_-helice NOUN sq87br88s6n 4 28 , , PUNCT sq87br88s6n 4 29 indicating indicate VERB sq87br88s6n 4 30 this this DET sq87br88s6n 4 31 structural structural ADJ sq87br88s6n 4 32 topology topology NOUN sq87br88s6n 4 33 may may AUX sq87br88s6n 4 34 be be AUX sq87br88s6n 4 35 important important ADJ sq87br88s6n 4 36 for for ADP sq87br88s6n 4 37 secretion secretion NOUN sq87br88s6n 4 38 . . PUNCT sq87br88s6n 5 1 we we PRON sq87br88s6n 5 2 report report VERB sq87br88s6n 5 3 the the DET sq87br88s6n 5 4 folding fold VERB sq87br88s6n 5 5 behavior behavior NOUN sq87br88s6n 5 6 of of ADP sq87br88s6n 5 7 pertactin pertactin NOUN sq87br88s6n 5 8 , , PUNCT sq87br88s6n 5 9 an an DET sq87br88s6n 5 10 autotransporter autotransporter NOUN sq87br88s6n 5 11 passenger passenger NOUN sq87br88s6n 5 12 domain domain NOUN sq87br88s6n 5 13 from from ADP sq87br88s6n 5 14 bordetella bordetella NOUN sq87br88s6n 5 15 pertussis pertussis NOUN sq87br88s6n 5 16 . . PUNCT sq87br88s6n 6 1 the the DET sq87br88s6n 6 2 pertactin pertactin ADJ sq87br88s6n 6 3 ì_å_-helix ì_å_-helix PROPN sq87br88s6n 6 4 folds fold VERB sq87br88s6n 6 5 reversibly reversibly ADV sq87br88s6n 6 6 in in ADP sq87br88s6n 6 7 isolation isolation NOUN sq87br88s6n 6 8 , , PUNCT sq87br88s6n 6 9 but but CCONJ sq87br88s6n 6 10 folding fold VERB sq87br88s6n 6 11 is be AUX sq87br88s6n 6 12 much much ADV sq87br88s6n 6 13 slower slow ADJ sq87br88s6n 6 14 than than SCONJ sq87br88s6n 6 15 expected expect VERB sq87br88s6n 6 16 based base VERB sq87br88s6n 6 17 on on ADP sq87br88s6n 6 18 size size NOUN sq87br88s6n 6 19 and and CCONJ sq87br88s6n 6 20 native native ADJ sq87br88s6n 6 21 - - PUNCT sq87br88s6n 6 22 state state NOUN sq87br88s6n 6 23 topology topology NOUN sq87br88s6n 6 24 . . PUNCT sq87br88s6n 7 1 surprisingly surprisingly ADV sq87br88s6n 7 2 , , PUNCT sq87br88s6n 7 3 pertactin pertactin NOUN sq87br88s6n 7 4 is be AUX sq87br88s6n 7 5 not not PART sq87br88s6n 7 6 prone prone ADJ sq87br88s6n 7 7 to to ADP sq87br88s6n 7 8 aggregation aggregation NOUN sq87br88s6n 7 9 during during ADP sq87br88s6n 7 10 folding fold VERB sq87br88s6n 7 11 , , PUNCT sq87br88s6n 7 12 even even ADV sq87br88s6n 7 13 though though SCONJ sq87br88s6n 7 14 folding fold VERB sq87br88s6n 7 15 is be AUX sq87br88s6n 7 16 extremely extremely ADV sq87br88s6n 7 17 slow slow ADJ sq87br88s6n 7 18 . . PUNCT sq87br88s6n 8 1 interestingly interestingly ADV sq87br88s6n 8 2 , , PUNCT sq87br88s6n 8 3 equilibrium equilibrium NOUN sq87br88s6n 8 4 denaturation denaturation NOUN sq87br88s6n 8 5 results result NOUN sq87br88s6n 8 6 in in ADP sq87br88s6n 8 7 the the DET sq87br88s6n 8 8 formation formation NOUN sq87br88s6n 8 9 of of ADP sq87br88s6n 8 10 a a DET sq87br88s6n 8 11 partially partially ADV sq87br88s6n 8 12 folded fold VERB sq87br88s6n 8 13 structure structure NOUN sq87br88s6n 8 14 , , PUNCT sq87br88s6n 8 15 a a DET sq87br88s6n 8 16 stable stable ADJ sq87br88s6n 8 17 core core NOUN sq87br88s6n 8 18 comprising comprise VERB sq87br88s6n 8 19 the the DET sq87br88s6n 8 20 c c NOUN sq87br88s6n 8 21 - - PUNCT sq87br88s6n 8 22 terminal terminal NOUN sq87br88s6n 8 23 half half NOUN sq87br88s6n 8 24 of of ADP sq87br88s6n 8 25 the the DET sq87br88s6n 8 26 protein protein NOUN sq87br88s6n 8 27 . . PUNCT sq87br88s6n 9 1 examination examination NOUN sq87br88s6n 9 2 of of ADP sq87br88s6n 9 3 the the DET sq87br88s6n 9 4 pertactin pertactin PROPN sq87br88s6n 9 5 crystal crystal PROPN sq87br88s6n 9 6 structure structure NOUN sq87br88s6n 9 7 does do AUX sq87br88s6n 9 8 not not PART sq87br88s6n 9 9 reveal reveal VERB sq87br88s6n 9 10 any any DET sq87br88s6n 9 11 obvious obvious ADJ sq87br88s6n 9 12 reason reason NOUN sq87br88s6n 9 13 for for ADP sq87br88s6n 9 14 the the DET sq87br88s6n 9 15 enhanced enhanced ADJ sq87br88s6n 9 16 stability stability NOUN sq87br88s6n 9 17 of of ADP sq87br88s6n 9 18 the the DET sq87br88s6n 9 19 c c NOUN sq87br88s6n 9 20 - - PUNCT sq87br88s6n 9 21 terminus terminus NOUN sq87br88s6n 9 22 . . PUNCT sq87br88s6n 10 1 crystallographic crystallographic ADJ sq87br88s6n 10 2 data datum NOUN sq87br88s6n 10 3 of of ADP sq87br88s6n 10 4 the the DET sq87br88s6n 10 5 partially partially ADV sq87br88s6n 10 6 folded fold VERB sq87br88s6n 10 7 state state NOUN sq87br88s6n 10 8 implies imply VERB sq87br88s6n 10 9 a a DET sq87br88s6n 10 10 native native ADJ sq87br88s6n 10 11 like like ADP sq87br88s6n 10 12 structure structure NOUN sq87br88s6n 10 13 for for ADP sq87br88s6n 10 14 the the DET sq87br88s6n 10 15 c c NOUN sq87br88s6n 10 16 - - PUNCT sq87br88s6n 10 17 terminus terminus NOUN sq87br88s6n 10 18 . . PUNCT sq87br88s6n 11 1 interestingly interestingly ADV sq87br88s6n 11 2 , , PUNCT sq87br88s6n 11 3 the the DET sq87br88s6n 11 4 c c NOUN sq87br88s6n 11 5 - - PUNCT sq87br88s6n 11 6 terminus terminus NOUN sq87br88s6n 11 7 forms form VERB sq87br88s6n 11 8 a a DET sq87br88s6n 11 9 dimer dimer NOUN sq87br88s6n 11 10 with with ADP sq87br88s6n 11 11 a a DET sq87br88s6n 11 12 non non ADJ sq87br88s6n 11 13 - - ADJ sq87br88s6n 11 14 native native ADJ sq87br88s6n 11 15 interface interface NOUN sq87br88s6n 11 16 . . PUNCT sq87br88s6n 12 1 this this DET sq87br88s6n 12 2 interface interface NOUN sq87br88s6n 12 3 has have VERB sq87br88s6n 12 4 a a DET sq87br88s6n 12 5 relatively relatively ADV sq87br88s6n 12 6 low low ADJ sq87br88s6n 12 7 kd kd NOUN sq87br88s6n 12 8 ~ ~ PROPN sq87br88s6n 12 9 0.3 0.3 NUM sq87br88s6n 12 10 ìâåµm ìâåµm NOUN sq87br88s6n 12 11 . . PUNCT sq87br88s6n 13 1 in in ADP sq87br88s6n 13 2 vivo vivo PROPN sq87br88s6n 13 3 , , PUNCT sq87br88s6n 13 4 slow slow ADJ sq87br88s6n 13 5 folding folding NOUN sq87br88s6n 13 6 would would AUX sq87br88s6n 13 7 prevent prevent VERB sq87br88s6n 13 8 premature premature ADJ sq87br88s6n 13 9 folding folding NOUN sq87br88s6n 13 10 of of ADP sq87br88s6n 13 11 the the DET sq87br88s6n 13 12 passenger passenger NOUN sq87br88s6n 13 13 domain domain NOUN sq87br88s6n 13 14 in in ADP sq87br88s6n 13 15 the the DET sq87br88s6n 13 16 periplasm periplasm NOUN sq87br88s6n 13 17 , , PUNCT sq87br88s6n 13 18 before before ADP sq87br88s6n 13 19 om om PROPN sq87br88s6n 13 20 secretion secretion NOUN sq87br88s6n 13 21 . . PUNCT sq87br88s6n 14 1 moreover moreover ADV sq87br88s6n 14 2 , , PUNCT sq87br88s6n 14 3 the the DET sq87br88s6n 14 4 extra extra ADJ sq87br88s6n 14 5 stability stability NOUN sq87br88s6n 14 6 of of ADP sq87br88s6n 14 7 the the DET sq87br88s6n 14 8 c c NOUN sq87br88s6n 14 9 - - PUNCT sq87br88s6n 14 10 terminal terminal ADJ sq87br88s6n 14 11 rungs rung NOUN sq87br88s6n 14 12 of of ADP sq87br88s6n 14 13 the the DET sq87br88s6n 14 14 ì_å_-helix ì_å_-helix PROPN sq87br88s6n 14 15 might might AUX sq87br88s6n 14 16 serve serve VERB sq87br88s6n 14 17 as as ADP sq87br88s6n 14 18 a a DET sq87br88s6n 14 19 template template NOUN sq87br88s6n 14 20 for for ADP sq87br88s6n 14 21 the the DET sq87br88s6n 14 22 formation formation NOUN sq87br88s6n 14 23 of of ADP sq87br88s6n 14 24 native native ADJ sq87br88s6n 14 25 protein protein NOUN sq87br88s6n 14 26 during during ADP sq87br88s6n 14 27 om om NOUN sq87br88s6n 14 28 secretion secretion NOUN sq87br88s6n 14 29 ; ; PUNCT sq87br88s6n 14 30 hence hence ADV sq87br88s6n 14 31 , , PUNCT sq87br88s6n 14 32 vectorial vectorial ADJ sq87br88s6n 14 33 folding folding NOUN sq87br88s6n 14 34 of of ADP sq87br88s6n 14 35 the the DET sq87br88s6n 14 36 ì_å_-helix ì_å_-helix PROPN sq87br88s6n 14 37 could could AUX sq87br88s6n 14 38 contribute contribute VERB sq87br88s6n 14 39 to to ADP sq87br88s6n 14 40 the the DET sq87br88s6n 14 41 energy energy NOUN sq87br88s6n 14 42 - - PUNCT sq87br88s6n 14 43 independent independent ADJ sq87br88s6n 14 44 translocation translocation NOUN sq87br88s6n 14 45 mechanism mechanism NOUN sq87br88s6n 14 46 . . PUNCT sq87br88s6n 15 1 we we PRON sq87br88s6n 15 2 show show VERB sq87br88s6n 15 3 here here ADV sq87br88s6n 15 4 that that SCONJ sq87br88s6n 15 5 the the DET sq87br88s6n 15 6 c c NOUN sq87br88s6n 15 7 - - PUNCT sq87br88s6n 15 8 terminus terminus NOUN sq87br88s6n 15 9 is be AUX sq87br88s6n 15 10 the the DET sq87br88s6n 15 11 first first ADJ sq87br88s6n 15 12 part part NOUN sq87br88s6n 15 13 of of ADP sq87br88s6n 15 14 the the DET sq87br88s6n 15 15 pertactin pertactin ADJ sq87br88s6n 15 16 passenger passenger NOUN sq87br88s6n 15 17 domain domain NOUN sq87br88s6n 15 18 reaching reach VERB sq87br88s6n 15 19 the the DET sq87br88s6n 15 20 om om NOUN sq87br88s6n 15 21 , , PUNCT sq87br88s6n 15 22 and and CCONJ sq87br88s6n 15 23 that that SCONJ sq87br88s6n 15 24 the the DET sq87br88s6n 15 25 c c NOUN sq87br88s6n 15 26 - - PUNCT sq87br88s6n 15 27 terminus terminus NOUN sq87br88s6n 15 28 can can AUX sq87br88s6n 15 29 adopt adopt VERB sq87br88s6n 15 30 a a DET sq87br88s6n 15 31 stable stable ADJ sq87br88s6n 15 32 structure structure NOUN sq87br88s6n 15 33 outside outside ADP sq87br88s6n 15 34 the the DET sq87br88s6n 15 35 cell cell NOUN sq87br88s6n 15 36 , , PUNCT sq87br88s6n 15 37 prior prior ADV sq87br88s6n 15 38 to to ADP sq87br88s6n 15 39 the the DET sq87br88s6n 15 40 completion completion NOUN sq87br88s6n 15 41 of of ADP sq87br88s6n 15 42 om om PROPN sq87br88s6n 15 43 secretion secretion NOUN sq87br88s6n 15 44 . . PUNCT sq87br88s6n 16 1 coupled couple VERB sq87br88s6n 16 2 with with ADP sq87br88s6n 16 3 the the DET sq87br88s6n 16 4 sequence sequence NOUN sq87br88s6n 16 5 analysis analysis NOUN sq87br88s6n 16 6 , , PUNCT sq87br88s6n 16 7 these these DET sq87br88s6n 16 8 results result NOUN sq87br88s6n 16 9 suggest suggest VERB sq87br88s6n 16 10 a a DET sq87br88s6n 16 11 general general ADJ sq87br88s6n 16 12 mechanism mechanism NOUN sq87br88s6n 16 13 for for ADP sq87br88s6n 16 14 autotransporter autotransporter NOUN sq87br88s6n 16 15 secretion secretion NOUN sq87br88s6n 16 16 . . PUNCT sq87br88s6n 17 1 the the DET sq87br88s6n 17 2 combination combination NOUN sq87br88s6n 17 3 of of ADP sq87br88s6n 17 4 this this DET sq87br88s6n 17 5 data datum NOUN sq87br88s6n 17 6 , , PUNCT sq87br88s6n 17 7 including include VERB sq87br88s6n 17 8 the the DET sq87br88s6n 17 9 lack lack NOUN sq87br88s6n 17 10 of of ADP sq87br88s6n 17 11 pertactin pertactin ADJ sq87br88s6n 17 12 aggregation aggregation NOUN sq87br88s6n 17 13 , , PUNCT sq87br88s6n 17 14 could could AUX sq87br88s6n 17 15 lead lead VERB sq87br88s6n 17 16 to to ADP sq87br88s6n 17 17 new new ADJ sq87br88s6n 17 18 insights insight NOUN sq87br88s6n 17 19 into into ADP sq87br88s6n 17 20 the the DET sq87br88s6n 17 21 formation formation NOUN sq87br88s6n 17 22 and and CCONJ sq87br88s6n 17 23 prevention prevention NOUN sq87br88s6n 17 24 of of ADP sq87br88s6n 17 25 protein protein NOUN sq87br88s6n 17 26 aggregation aggregation NOUN sq87br88s6n 17 27 in in ADP sq87br88s6n 17 28 vivo vivo PROPN sq87br88s6n 17 29 . . PUNCT