id	sid	tid	token	lemma	pos
sj139022736	1	1	3'-azido-3'-deoxythymidine	3'-azido-3'-deoxythymidine	X
sj139022736	1	2	(	(	PUNCT
sj139022736	1	3	azt	azt	PROPN
sj139022736	1	4	)	)	PUNCT
sj139022736	1	5	has	have	AUX
sj139022736	1	6	been	be	AUX
sj139022736	1	7	a	a	DET
sj139022736	1	8	staple	staple	NOUN
sj139022736	1	9	of	of	ADP
sj139022736	1	10	aids	aids	PROPN
sj139022736	1	11	therapy	therapy	NOUN
sj139022736	1	12	for	for	ADP
sj139022736	1	13	over	over	ADP
sj139022736	1	14	two	two	NUM
sj139022736	1	15	decades	decade	NOUN
sj139022736	1	16	.	.	PUNCT
sj139022736	2	1	long	long	ADJ
sj139022736	2	2	-	-	PUNCT
sj139022736	2	3	term	term	NOUN
sj139022736	2	4	use	use	NOUN
sj139022736	2	5	of	of	ADP
sj139022736	2	6	high	high	ADJ
sj139022736	2	7	dosage	dosage	NOUN
sj139022736	2	8	azt	azt	NOUN
sj139022736	2	9	,	,	PUNCT
sj139022736	2	10	as	as	SCONJ
sj139022736	2	11	seen	see	VERB
sj139022736	2	12	in	in	ADP
sj139022736	2	13	the	the	DET
sj139022736	2	14	late	late	ADJ
sj139022736	2	15	1980	1980	NUM
sj139022736	2	16	's	's	PART
sj139022736	2	17	and	and	CCONJ
sj139022736	2	18	early	early	ADJ
sj139022736	2	19	1990	1990	NUM
sj139022736	2	20	's	's	PART
sj139022736	2	21	,	,	PUNCT
sj139022736	2	22	was	be	AUX
sj139022736	2	23	associated	associate	VERB
sj139022736	2	24	with	with	ADP
sj139022736	2	25	tissue	tissue	NOUN
sj139022736	2	26	toxicities	toxicity	NOUN
sj139022736	2	27	,	,	PUNCT
sj139022736	2	28	including	include	VERB
sj139022736	2	29	hepatotoxicity	hepatotoxicity	NOUN
sj139022736	2	30	and	and	CCONJ
sj139022736	2	31	cardiomyopathy	cardiomyopathy	PROPN
sj139022736	2	32	.	.	PUNCT
sj139022736	3	1	low	low	ADJ
sj139022736	3	2	dosage	dosage	NOUN
sj139022736	3	3	azt	azt	PROPN
sj139022736	3	4	therapy	therapy	PROPN
sj139022736	3	5	used	use	VERB
sj139022736	3	6	in	in	ADP
sj139022736	3	7	modern	modern	ADJ
sj139022736	3	8	regimens	regimen	NOUN
sj139022736	3	9	is	be	AUX
sj139022736	3	10	associated	associate	VERB
sj139022736	3	11	with	with	ADP
sj139022736	3	12	lipodystrophy	lipodystrophy	PROPN
sj139022736	3	13	.	.	PUNCT
sj139022736	4	1	mitochondria	mitochondria	PROPN
sj139022736	4	2	in	in	ADP
sj139022736	4	3	the	the	DET
sj139022736	4	4	affected	affected	ADJ
sj139022736	4	5	tissues	tissue	NOUN
sj139022736	4	6	are	be	AUX
sj139022736	4	7	dysfunctional	dysfunctional	ADJ
sj139022736	4	8	and	and	CCONJ
sj139022736	4	9	have	have	AUX
sj139022736	4	10	depleted	deplete	VERB
sj139022736	4	11	mitochondrial	mitochondrial	ADJ
sj139022736	4	12	dna	dna	PROPN
sj139022736	4	13	.	.	PUNCT
sj139022736	5	1	the	the	DET
sj139022736	5	2	toxicity	toxicity	NOUN
sj139022736	5	3	of	of	ADP
sj139022736	5	4	azt	azt	PROPN
sj139022736	5	5	is	be	AUX
sj139022736	5	6	hypothesized	hypothesize	VERB
sj139022736	5	7	to	to	PART
sj139022736	5	8	be	be	AUX
sj139022736	5	9	due	due	ADJ
sj139022736	5	10	to	to	PART
sj139022736	5	11	azt-5'-triphosphate	azt-5'-triphosphate	VERB
sj139022736	5	12	(	(	PUNCT
sj139022736	5	13	azt	azt	PROPN
sj139022736	5	14	-	-	PUNCT
sj139022736	5	15	tp	tp	PROPN
sj139022736	5	16	)	)	PUNCT
sj139022736	5	17	inhibition	inhibition	NOUN
sj139022736	5	18	of	of	ADP
sj139022736	5	19	the	the	DET
sj139022736	5	20	mitochondrial	mitochondrial	ADJ
sj139022736	5	21	dna	dna	PROPN
sj139022736	5	22	polymerase	polymerase	NOUN
sj139022736	5	23	&	&	CCONJ
sj139022736	5	24	gamma	gamma	NOUN
sj139022736	5	25	;	;	PUNCT
sj139022736	5	26	,	,	PUNCT
sj139022736	5	27	leading	lead	VERB
sj139022736	5	28	to	to	ADP
sj139022736	5	29	mitochondrial	mitochondrial	ADJ
sj139022736	5	30	dna	dna	NOUN
sj139022736	5	31	depletion	depletion	NOUN
sj139022736	5	32	.	.	PUNCT
sj139022736	6	1	in	in	ADP
sj139022736	6	2	this	this	DET
sj139022736	6	3	work	work	NOUN
sj139022736	6	4	with	with	ADP
sj139022736	6	5	isolated	isolated	ADJ
sj139022736	6	6	rat	rat	NOUN
sj139022736	6	7	liver	liver	NOUN
sj139022736	6	8	mitochondria	mitochondria	NOUN
sj139022736	6	9	and	and	CCONJ
sj139022736	6	10	previous	previous	ADJ
sj139022736	6	11	work	work	NOUN
sj139022736	6	12	with	with	ADP
sj139022736	6	13	isolated	isolated	ADJ
sj139022736	6	14	rat	rat	NOUN
sj139022736	6	15	heart	heart	NOUN
sj139022736	6	16	mitochondria	mitochondria	PROPN
sj139022736	6	17	,	,	PUNCT
sj139022736	6	18	azt	azt	PROPN
sj139022736	6	19	was	be	AUX
sj139022736	6	20	phosphorylated	phosphorylate	VERB
sj139022736	6	21	to	to	ADP
sj139022736	6	22	azt-5'-monophosphate	azt-5'-monophosphate	ADJ
sj139022736	6	23	(	(	PUNCT
sj139022736	6	24	azt	azt	PROPN
sj139022736	6	25	-	-	PUNCT
sj139022736	6	26	mp	mp	PROPN
sj139022736	6	27	)	)	PUNCT
sj139022736	6	28	,	,	PUNCT
sj139022736	6	29	but	but	CCONJ
sj139022736	6	30	no	no	DET
sj139022736	6	31	azt	azt	NOUN
sj139022736	6	32	-	-	PUNCT
sj139022736	6	33	tp	tp	PROPN
sj139022736	6	34	was	be	AUX
sj139022736	6	35	detectable	detectable	ADJ
sj139022736	6	36	over	over	ADP
sj139022736	6	37	two	two	NUM
sj139022736	6	38	hours	hour	NOUN
sj139022736	6	39	of	of	ADP
sj139022736	6	40	incubation	incubation	NOUN
sj139022736	6	41	.	.	PUNCT
sj139022736	7	1	however	however	ADV
sj139022736	7	2	,	,	PUNCT
sj139022736	7	3	in	in	ADP
sj139022736	7	4	these	these	DET
sj139022736	7	5	mitochondria	mitochondria	NOUN
sj139022736	7	6	,	,	PUNCT
sj139022736	7	7	azt	azt	PROPN
sj139022736	7	8	was	be	AUX
sj139022736	7	9	shown	show	VERB
sj139022736	7	10	to	to	PART
sj139022736	7	11	be	be	AUX
sj139022736	7	12	a	a	DET
sj139022736	7	13	potent	potent	ADJ
sj139022736	7	14	competitive	competitive	ADJ
sj139022736	7	15	inhibitor	inhibitor	NOUN
sj139022736	7	16	of	of	ADP
sj139022736	7	17	thymidine	thymidine	NOUN
sj139022736	7	18	phosphorylation	phosphorylation	NOUN
sj139022736	7	19	.	.	PUNCT
sj139022736	8	1	from	from	ADP
sj139022736	8	2	this	this	DET
sj139022736	8	3	work	work	NOUN
sj139022736	8	4	,	,	PUNCT
sj139022736	8	5	an	an	DET
sj139022736	8	6	alternative	alternative	ADJ
sj139022736	8	7	mechanism	mechanism	NOUN
sj139022736	8	8	for	for	ADP
sj139022736	8	9	azt	azt	PROPN
sj139022736	8	10	toxicity	toxicity	NOUN
sj139022736	8	11	was	be	AUX
sj139022736	8	12	proposed	propose	VERB
sj139022736	8	13	,	,	PUNCT
sj139022736	8	14	wherein	wherein	SCONJ
sj139022736	8	15	azt	azt	PROPN
sj139022736	8	16	's	's	PART
sj139022736	8	17	inhibition	inhibition	NOUN
sj139022736	8	18	of	of	ADP
sj139022736	8	19	thymidine	thymidine	NOUN
sj139022736	8	20	phosphorylation	phosphorylation	NOUN
sj139022736	8	21	leads	lead	VERB
sj139022736	8	22	to	to	ADP
sj139022736	8	23	a	a	DET
sj139022736	8	24	depletion	depletion	NOUN
sj139022736	8	25	of	of	ADP
sj139022736	8	26	the	the	DET
sj139022736	8	27	ttp	ttp	NOUN
sj139022736	8	28	pool	pool	NOUN
sj139022736	8	29	,	,	PUNCT
sj139022736	8	30	which	which	PRON
sj139022736	8	31	causes	cause	VERB
sj139022736	8	32	mitochondrial	mitochondrial	ADJ
sj139022736	8	33	dna	dna	NOUN
sj139022736	8	34	depletion	depletion	NOUN
sj139022736	8	35	.	.	PUNCT
sj139022736	9	1	the	the	DET
sj139022736	9	2	3t3	3t3	NUM
sj139022736	9	3	-	-	PUNCT
sj139022736	9	4	f442a	f442a	PROPN
sj139022736	9	5	cell	cell	NOUN
sj139022736	9	6	culture	culture	NOUN
sj139022736	9	7	model	model	NOUN
sj139022736	9	8	was	be	AUX
sj139022736	9	9	used	use	VERB
sj139022736	9	10	to	to	PART
sj139022736	9	11	further	far	ADV
sj139022736	9	12	investigate	investigate	VERB
sj139022736	9	13	this	this	DET
sj139022736	9	14	mechanism	mechanism	NOUN
sj139022736	9	15	of	of	ADP
sj139022736	9	16	toxicity	toxicity	NOUN
sj139022736	9	17	.	.	PUNCT
sj139022736	10	1	these	these	DET
sj139022736	10	2	cells	cell	NOUN
sj139022736	10	3	are	be	AUX
sj139022736	10	4	mouse	mouse	NOUN
sj139022736	10	5	pre	pre	NOUN
sj139022736	10	6	-	-	NOUN
sj139022736	10	7	adipocytes	adipocyte	NOUN
sj139022736	10	8	that	that	PRON
sj139022736	10	9	can	can	AUX
sj139022736	10	10	be	be	AUX
sj139022736	10	11	differentiated	differentiate	VERB
sj139022736	10	12	into	into	ADP
sj139022736	10	13	adipocytes	adipocyte	NOUN
sj139022736	10	14	,	,	PUNCT
sj139022736	10	15	making	make	VERB
sj139022736	10	16	these	these	DET
sj139022736	10	17	cells	cell	NOUN
sj139022736	10	18	a	a	DET
sj139022736	10	19	good	good	ADJ
sj139022736	10	20	model	model	NOUN
sj139022736	10	21	for	for	ADP
sj139022736	10	22	lipodystrophy	lipodystrophy	NOUN
sj139022736	10	23	.	.	PUNCT
sj139022736	11	1	the	the	DET
sj139022736	11	2	3t3	3t3	NUM
sj139022736	11	3	-	-	PUNCT
sj139022736	11	4	f442a	f442a	NOUN
sj139022736	11	5	cells	cell	NOUN
sj139022736	11	6	were	be	AUX
sj139022736	11	7	grown	grow	VERB
sj139022736	11	8	and	and	CCONJ
sj139022736	11	9	differentiated	differentiate	VERB
sj139022736	11	10	in	in	ADP
sj139022736	11	11	the	the	DET
sj139022736	11	12	presence	presence	NOUN
sj139022736	11	13	of	of	ADP
sj139022736	11	14	1	1	NUM
sj139022736	11	15	and	and	CCONJ
sj139022736	11	16	10	10	NUM
sj139022736	11	17	ì_å_m	ì_å_m	PROPN
sj139022736	11	18	azt	azt	NOUN
sj139022736	11	19	for	for	ADP
sj139022736	11	20	12	12	NUM
sj139022736	11	21	days	day	NOUN
sj139022736	11	22	.	.	PUNCT
sj139022736	12	1	samples	sample	NOUN
sj139022736	12	2	were	be	AUX
sj139022736	12	3	analyzed	analyze	VERB
sj139022736	12	4	to	to	PART
sj139022736	12	5	determine	determine	VERB
sj139022736	12	6	mitochondrial	mitochondrial	ADJ
sj139022736	12	7	dna	dna	NOUN
sj139022736	12	8	content	content	NOUN
sj139022736	12	9	and	and	CCONJ
sj139022736	12	10	deoxynuceloside	deoxynuceloside	ADJ
sj139022736	12	11	-	-	PUNCT
sj139022736	12	12	triphosphate	triphosphate	NOUN
sj139022736	12	13	(	(	PUNCT
sj139022736	12	14	dntp	dntp	ADJ
sj139022736	12	15	)	)	PUNCT
sj139022736	12	16	levels	level	NOUN
sj139022736	12	17	.	.	PUNCT
sj139022736	13	1	both	both	PRON
sj139022736	13	2	1	1	NUM
sj139022736	13	3	and	and	CCONJ
sj139022736	13	4	10	10	NUM
sj139022736	13	5	ì_å_m	ì_å_m	PROPN
sj139022736	13	6	azt	azt	NOUN
sj139022736	13	7	were	be	AUX
sj139022736	13	8	toxic	toxic	ADJ
sj139022736	13	9	to	to	ADP
sj139022736	13	10	mitochondria	mitochondria	VERB
sj139022736	13	11	but	but	CCONJ
sj139022736	13	12	caused	cause	VERB
sj139022736	13	13	a	a	DET
sj139022736	13	14	significant	significant	ADJ
sj139022736	13	15	increase	increase	NOUN
sj139022736	13	16	in	in	ADP
sj139022736	13	17	mitochondrial	mitochondrial	ADJ
sj139022736	13	18	dna	dna	NOUN
sj139022736	13	19	content	content	NOUN
sj139022736	13	20	relative	relative	ADJ
sj139022736	13	21	to	to	ADP
sj139022736	13	22	untreated	untreated	ADJ
sj139022736	13	23	cells	cell	NOUN
sj139022736	13	24	.	.	PUNCT
sj139022736	14	1	this	this	PRON
sj139022736	14	2	is	be	AUX
sj139022736	14	3	the	the	DET
sj139022736	14	4	opposite	opposite	NOUN
sj139022736	14	5	of	of	ADP
sj139022736	14	6	the	the	DET
sj139022736	14	7	expected	expect	VERB
sj139022736	14	8	effect	effect	NOUN
sj139022736	14	9	and	and	CCONJ
sj139022736	14	10	may	may	AUX
sj139022736	14	11	reflect	reflect	VERB
sj139022736	14	12	a	a	DET
sj139022736	14	13	compensatory	compensatory	ADJ
sj139022736	14	14	mechanism	mechanism	NOUN
sj139022736	14	15	to	to	PART
sj139022736	14	16	overcome	overcome	VERB
sj139022736	14	17	toxicity	toxicity	NOUN
sj139022736	14	18	.	.	PUNCT
sj139022736	15	1	also	also	ADV
sj139022736	15	2	,	,	PUNCT
sj139022736	15	3	azt	azt	PROPN
sj139022736	15	4	did	do	AUX
sj139022736	15	5	not	not	PART
sj139022736	15	6	cause	cause	VERB
sj139022736	15	7	any	any	DET
sj139022736	15	8	trend	trend	NOUN
sj139022736	15	9	of	of	ADP
sj139022736	15	10	variation	variation	NOUN
sj139022736	15	11	from	from	ADP
sj139022736	15	12	the	the	DET
sj139022736	15	13	untreated	untreated	ADJ
sj139022736	15	14	cells	cell	NOUN
sj139022736	15	15	in	in	ADP
sj139022736	15	16	the	the	DET
sj139022736	15	17	dntp	dntp	ADJ
sj139022736	15	18	pools	pool	NOUN
sj139022736	15	19	during	during	ADP
sj139022736	15	20	the	the	DET
sj139022736	15	21	12	12	NUM
sj139022736	15	22	days	day	NOUN
sj139022736	15	23	of	of	ADP
sj139022736	15	24	treatment	treatment	NOUN
sj139022736	15	25	.	.	PUNCT
sj139022736	16	1	these	these	DET
sj139022736	16	2	results	result	NOUN
sj139022736	16	3	do	do	AUX
sj139022736	16	4	not	not	PART
sj139022736	16	5	provide	provide	VERB
sj139022736	16	6	any	any	DET
sj139022736	16	7	further	further	ADJ
sj139022736	16	8	evidence	evidence	NOUN
sj139022736	16	9	to	to	PART
sj139022736	16	10	advance	advance	VERB
sj139022736	16	11	the	the	DET
sj139022736	16	12	proposed	propose	VERB
sj139022736	16	13	mechanism	mechanism	NOUN
sj139022736	16	14	of	of	ADP
sj139022736	16	15	azt	azt	PROPN
sj139022736	16	16	toxicity	toxicity	NOUN
sj139022736	16	17	due	due	ADP
sj139022736	16	18	to	to	ADP
sj139022736	16	19	azt	azt	PROPN
sj139022736	16	20	inhibition	inhibition	NOUN
sj139022736	16	21	of	of	ADP
sj139022736	16	22	thymidine	thymidine	NOUN
sj139022736	16	23	phosphorylation	phosphorylation	NOUN
sj139022736	16	24	.	.	PUNCT