id	sid	tid	token	lemma	pos
sb397656k5b	1	1	endochondral	endochondral	ADJ
sb397656k5b	1	2	ossification	ossification	NOUN
sb397656k5b	1	3	is	be	AUX
sb397656k5b	1	4	an	an	DET
sb397656k5b	1	5	indirect	indirect	ADJ
sb397656k5b	1	6	path	path	NOUN
sb397656k5b	1	7	of	of	ADP
sb397656k5b	1	8	bone	bone	NOUN
sb397656k5b	1	9	formation	formation	NOUN
sb397656k5b	1	10	involving	involve	VERB
sb397656k5b	1	11	the	the	DET
sb397656k5b	1	12	condensation	condensation	NOUN
sb397656k5b	1	13	of	of	ADP
sb397656k5b	1	14	progenitor	progenitor	NOUN
sb397656k5b	1	15	cells	cell	NOUN
sb397656k5b	1	16	into	into	ADP
sb397656k5b	1	17	a	a	DET
sb397656k5b	1	18	cartilaginous	cartilaginous	ADJ
sb397656k5b	1	19	anlage	anlage	NOUN
sb397656k5b	1	20	that	that	PRON
sb397656k5b	1	21	grows	grow	VERB
sb397656k5b	1	22	in	in	ADP
sb397656k5b	1	23	size	size	NOUN
sb397656k5b	1	24	,	,	PUNCT
sb397656k5b	1	25	matures	mature	NOUN
sb397656k5b	1	26	,	,	PUNCT
sb397656k5b	1	27	and	and	CCONJ
sb397656k5b	1	28	releases	release	VERB
sb397656k5b	1	29	growth	growth	NOUN
sb397656k5b	1	30	factors	factor	NOUN
sb397656k5b	1	31	to	to	PART
sb397656k5b	1	32	promote	promote	VERB
sb397656k5b	1	33	blood	blood	NOUN
sb397656k5b	1	34	vessel	vessel	NOUN
sb397656k5b	1	35	invasion	invasion	NOUN
sb397656k5b	1	36	and	and	CCONJ
sb397656k5b	1	37	cartilage	cartilage	NOUN
sb397656k5b	1	38	remodeling	remodeling	NOUN
sb397656k5b	1	39	,	,	PUNCT
sb397656k5b	1	40	resulting	result	VERB
sb397656k5b	1	41	in	in	ADP
sb397656k5b	1	42	a	a	DET
sb397656k5b	1	43	robust	robust	ADJ
sb397656k5b	1	44	,	,	PUNCT
sb397656k5b	1	45	vascularized	vascularized	ADJ
sb397656k5b	1	46	bone	bone	NOUN
sb397656k5b	1	47	organ	organ	NOUN
sb397656k5b	1	48	.	.	PUNCT
sb397656k5b	2	1	this	this	PRON
sb397656k5b	2	2	is	be	AUX
sb397656k5b	2	3	the	the	DET
sb397656k5b	2	4	dominant	dominant	ADJ
sb397656k5b	2	5	pathway	pathway	NOUN
sb397656k5b	2	6	of	of	ADP
sb397656k5b	2	7	bone	bone	NOUN
sb397656k5b	2	8	formation	formation	NOUN
sb397656k5b	2	9	in	in	ADP
sb397656k5b	2	10	both	both	PRON
sb397656k5b	2	11	long	long	ADJ
sb397656k5b	2	12	bone	bone	NOUN
sb397656k5b	2	13	development	development	NOUN
sb397656k5b	2	14	and	and	CCONJ
sb397656k5b	2	15	fracture	fracture	NOUN
sb397656k5b	2	16	healing	healing	NOUN
sb397656k5b	2	17	and	and	CCONJ
sb397656k5b	2	18	has	have	AUX
sb397656k5b	2	19	emerged	emerge	VERB
sb397656k5b	2	20	as	as	ADP
sb397656k5b	2	21	an	an	DET
sb397656k5b	2	22	attractive	attractive	ADJ
sb397656k5b	2	23	tissue	tissue	NOUN
sb397656k5b	2	24	engineering	engineering	NOUN
sb397656k5b	2	25	template	template	NOUN
sb397656k5b	2	26	to	to	PART
sb397656k5b	2	27	address	address	VERB
sb397656k5b	2	28	the	the	DET
sb397656k5b	2	29	lack	lack	NOUN
sb397656k5b	2	30	of	of	ADP
sb397656k5b	2	31	angiogenesis	angiogenesis	NOUN
sb397656k5b	2	32	and	and	CCONJ
sb397656k5b	2	33	poor	poor	ADJ
sb397656k5b	2	34	engraftment	engraftment	NOUN
sb397656k5b	2	35	seen	see	VERB
sb397656k5b	2	36	in	in	ADP
sb397656k5b	2	37	current	current	ADJ
sb397656k5b	2	38	intramembranous	intramembranous	ADJ
sb397656k5b	2	39	engineering	engineering	NOUN
sb397656k5b	2	40	approaches	approach	NOUN
sb397656k5b	2	41	.	.	PUNCT
sb397656k5b	3	1	though	though	SCONJ
sb397656k5b	3	2	it	it	PRON
sb397656k5b	3	3	is	be	AUX
sb397656k5b	3	4	known	know	VERB
sb397656k5b	3	5	that	that	SCONJ
sb397656k5b	3	6	mechanical	mechanical	ADJ
sb397656k5b	3	7	cues	cue	NOUN
sb397656k5b	3	8	are	be	AUX
sb397656k5b	3	9	essential	essential	ADJ
sb397656k5b	3	10	to	to	ADP
sb397656k5b	3	11	the	the	DET
sb397656k5b	3	12	progression	progression	NOUN
sb397656k5b	3	13	of	of	ADP
sb397656k5b	3	14	endochondral	endochondral	ADJ
sb397656k5b	3	15	ossification	ossification	NOUN
sb397656k5b	3	16	in	in	ADP
sb397656k5b	3	17	both	both	DET
sb397656k5b	3	18	processes	process	NOUN
sb397656k5b	3	19	,	,	PUNCT
sb397656k5b	3	20	the	the	DET
sb397656k5b	3	21	role	role	NOUN
sb397656k5b	3	22	of	of	ADP
sb397656k5b	3	23	mechanical	mechanical	ADJ
sb397656k5b	3	24	loading	loading	NOUN
sb397656k5b	3	25	in	in	ADP
sb397656k5b	3	26	endochondral	endochondral	ADJ
sb397656k5b	3	27	bone	bone	NOUN
sb397656k5b	3	28	defect	defect	NOUN
sb397656k5b	3	29	regeneration	regeneration	NOUN
sb397656k5b	3	30	has	have	AUX
sb397656k5b	3	31	not	not	PART
sb397656k5b	3	32	been	be	AUX
sb397656k5b	3	33	investigated	investigate	VERB
sb397656k5b	3	34	.	.	PUNCT
sb397656k5b	4	1	in	in	ADP
sb397656k5b	4	2	vivo	vivo	PROPN
sb397656k5b	4	3	,	,	PUNCT
sb397656k5b	4	4	we	we	PRON
sb397656k5b	4	5	applied	apply	VERB
sb397656k5b	4	6	mechanical	mechanical	ADJ
sb397656k5b	4	7	loading	loading	NOUN
sb397656k5b	4	8	to	to	ADP
sb397656k5b	4	9	chondrogenically	chondrogenically	ADV
sb397656k5b	4	10	-	-	PUNCT
sb397656k5b	4	11	primed	prime	VERB
sb397656k5b	4	12	hmscs	hmsc	NOUN
sb397656k5b	4	13	within	within	ADP
sb397656k5b	4	14	a	a	DET
sb397656k5b	4	15	critically	critically	ADV
sb397656k5b	4	16	-	-	PUNCT
sb397656k5b	4	17	sized	sized	ADJ
sb397656k5b	4	18	rat	rat	NOUN
sb397656k5b	4	19	femoral	femoral	ADJ
sb397656k5b	4	20	defect	defect	NOUN
sb397656k5b	4	21	either	either	CCONJ
sb397656k5b	4	22	immediately	immediately	ADV
sb397656k5b	4	23	after	after	ADP
sb397656k5b	4	24	implantation	implantation	NOUN
sb397656k5b	4	25	,	,	PUNCT
sb397656k5b	4	26	or	or	CCONJ
sb397656k5b	4	27	delayed	delay	VERB
sb397656k5b	4	28	until	until	ADP
sb397656k5b	4	29	4	4	NUM
sb397656k5b	4	30	weeks	week	NOUN
sb397656k5b	4	31	into	into	ADP
sb397656k5b	4	32	chondrogenesis	chondrogenesis	NOUN
sb397656k5b	4	33	,	,	PUNCT
sb397656k5b	4	34	compared	compare	VERB
sb397656k5b	4	35	to	to	ADP
sb397656k5b	4	36	unloaded	unloaded	ADJ
sb397656k5b	4	37	controls	control	NOUN
sb397656k5b	4	38	.	.	PUNCT
sb397656k5b	5	1	delaying	delay	VERB
sb397656k5b	5	2	loading	loading	NOUN
sb397656k5b	5	3	significantly	significantly	ADV
sb397656k5b	5	4	improved	improve	VERB
sb397656k5b	5	5	bone	bone	NOUN
sb397656k5b	5	6	regeneration	regeneration	NOUN
sb397656k5b	5	7	through	through	ADP
sb397656k5b	5	8	increased	increase	VERB
sb397656k5b	5	9	bone	bone	NOUN
sb397656k5b	5	10	volume	volume	NOUN
sb397656k5b	5	11	,	,	PUNCT
sb397656k5b	5	12	bridging	bridge	VERB
sb397656k5b	5	13	across	across	ADP
sb397656k5b	5	14	the	the	DET
sb397656k5b	5	15	defect	defect	NOUN
sb397656k5b	5	16	,	,	PUNCT
sb397656k5b	5	17	and	and	CCONJ
sb397656k5b	5	18	recovery	recovery	NOUN
sb397656k5b	5	19	of	of	ADP
sb397656k5b	5	20	mechanical	mechanical	ADJ
sb397656k5b	5	21	properties	property	NOUN
sb397656k5b	5	22	compared	compare	VERB
sb397656k5b	5	23	to	to	ADP
sb397656k5b	5	24	unloaded	unloaded	ADJ
sb397656k5b	5	25	controls	control	NOUN
sb397656k5b	5	26	,	,	PUNCT
sb397656k5b	5	27	and	and	CCONJ
sb397656k5b	5	28	this	this	PRON
sb397656k5b	5	29	was	be	AUX
sb397656k5b	5	30	further	far	ADV
sb397656k5b	5	31	potentiated	potentiate	VERB
sb397656k5b	5	32	by	by	ADP
sb397656k5b	5	33	supplementation	supplementation	NOUN
sb397656k5b	5	34	of	of	ADP
sb397656k5b	5	35	additional	additional	ADJ
sb397656k5b	5	36	growth	growth	NOUN
sb397656k5b	5	37	factors	factor	NOUN
sb397656k5b	5	38	.	.	PUNCT
sb397656k5b	6	1	conversely	conversely	ADV
sb397656k5b	6	2	,	,	PUNCT
sb397656k5b	6	3	early	early	ADV
sb397656k5b	6	4	loading	load	VERB
sb397656k5b	6	5	increased	increase	VERB
sb397656k5b	6	6	bone	bone	NOUN
sb397656k5b	6	7	volume	volume	NOUN
sb397656k5b	6	8	but	but	CCONJ
sb397656k5b	6	9	did	do	AUX
sb397656k5b	6	10	not	not	PART
sb397656k5b	6	11	enhance	enhance	VERB
sb397656k5b	6	12	bridging	bridging	NOUN
sb397656k5b	6	13	or	or	CCONJ
sb397656k5b	6	14	mechanical	mechanical	ADJ
sb397656k5b	6	15	properties	property	NOUN
sb397656k5b	6	16	.	.	PUNCT
sb397656k5b	7	1	there	there	PRON
sb397656k5b	7	2	was	be	VERB
sb397656k5b	7	3	significantly	significantly	ADV
sb397656k5b	7	4	decreased	decrease	VERB
sb397656k5b	7	5	vascular	vascular	ADJ
sb397656k5b	7	6	invasion	invasion	NOUN
sb397656k5b	7	7	and	and	CCONJ
sb397656k5b	7	8	persistent	persistent	ADJ
sb397656k5b	7	9	unmineralized	unmineralized	ADJ
sb397656k5b	7	10	gaps	gap	NOUN
sb397656k5b	7	11	of	of	ADP
sb397656k5b	7	12	cartilage	cartilage	NOUN
sb397656k5b	7	13	,	,	PUNCT
sb397656k5b	7	14	resulting	result	VERB
sb397656k5b	7	15	in	in	ADP
sb397656k5b	7	16	lack	lack	NOUN
sb397656k5b	7	17	of	of	ADP
sb397656k5b	7	18	functional	functional	ADJ
sb397656k5b	7	19	repair	repair	NOUN
sb397656k5b	7	20	.	.	PUNCT
sb397656k5b	8	1	this	this	PRON
sb397656k5b	8	2	suggests	suggest	VERB
sb397656k5b	8	3	that	that	SCONJ
sb397656k5b	8	4	the	the	DET
sb397656k5b	8	5	timing	timing	NOUN
sb397656k5b	8	6	of	of	ADP
sb397656k5b	8	7	in	in	ADP
sb397656k5b	8	8	vivo	vivo	ADJ
sb397656k5b	8	9	mechanical	mechanical	ADJ
sb397656k5b	8	10	loading	loading	NOUN
sb397656k5b	8	11	during	during	ADP
sb397656k5b	8	12	progenitor	progenitor	NOUN
sb397656k5b	8	13	cell	cell	NOUN
sb397656k5b	8	14	maturation	maturation	NOUN
sb397656k5b	8	15	is	be	AUX
sb397656k5b	8	16	an	an	DET
sb397656k5b	8	17	important	important	ADJ
sb397656k5b	8	18	factor	factor	NOUN
sb397656k5b	8	19	in	in	ADP
sb397656k5b	8	20	directing	direct	VERB
sb397656k5b	8	21	tissue	tissue	NOUN
sb397656k5b	8	22	formation	formation	NOUN
sb397656k5b	8	23	.	.	PUNCT
sb397656k5b	9	1	to	to	ADP
sb397656k5b	9	2	this	this	DET
sb397656k5b	9	3	end	end	NOUN
sb397656k5b	9	4	,	,	PUNCT
sb397656k5b	9	5	we	we	PRON
sb397656k5b	9	6	investigated	investigate	VERB
sb397656k5b	9	7	,	,	PUNCT
sb397656k5b	9	8	in	in	ADP
sb397656k5b	9	9	vitro	vitro	X
sb397656k5b	9	10	,	,	PUNCT
sb397656k5b	9	11	the	the	DET
sb397656k5b	9	12	role	role	NOUN
sb397656k5b	9	13	of	of	ADP
sb397656k5b	9	14	endochondral	endochondral	ADJ
sb397656k5b	9	15	priming	prime	VERB
sb397656k5b	9	16	length	length	NOUN
sb397656k5b	9	17	prior	prior	ADV
sb397656k5b	9	18	to	to	ADP
sb397656k5b	9	19	dynamic	dynamic	ADJ
sb397656k5b	9	20	compression	compression	NOUN
sb397656k5b	9	21	in	in	ADP
sb397656k5b	9	22	a	a	DET
sb397656k5b	9	23	custom	custom	ADV
sb397656k5b	9	24	-	-	PUNCT
sb397656k5b	9	25	made	make	VERB
sb397656k5b	9	26	bioreactor	bioreactor	NOUN
sb397656k5b	9	27	.	.	PUNCT
sb397656k5b	10	1	mechanical	mechanical	ADJ
sb397656k5b	10	2	load	load	NOUN
sb397656k5b	10	3	initiated	initiate	VERB
sb397656k5b	10	4	chondrogenic	chondrogenic	NOUN
sb397656k5b	10	5	gene	gene	NOUN
sb397656k5b	10	6	expression	expression	NOUN
sb397656k5b	10	7	at	at	ADP
sb397656k5b	10	8	all	all	DET
sb397656k5b	10	9	stages	stage	NOUN
sb397656k5b	10	10	,	,	PUNCT
sb397656k5b	10	11	but	but	CCONJ
sb397656k5b	10	12	only	only	ADV
sb397656k5b	10	13	enhanced	enhance	VERB
sb397656k5b	10	14	endochondral	endochondral	ADJ
sb397656k5b	10	15	progression	progression	NOUN
sb397656k5b	10	16	when	when	SCONJ
sb397656k5b	10	17	applied	apply	VERB
sb397656k5b	10	18	after	after	ADP
sb397656k5b	10	19	6	6	NUM
sb397656k5b	10	20	weeks	week	NOUN
sb397656k5b	10	21	of	of	ADP
sb397656k5b	10	22	priming	prime	VERB
sb397656k5b	10	23	.	.	PUNCT
sb397656k5b	11	1	loading	load	VERB
sb397656k5b	11	2	at	at	ADP
sb397656k5b	11	3	earlier	early	ADJ
sb397656k5b	11	4	stages	stage	NOUN
sb397656k5b	11	5	of	of	ADP
sb397656k5b	11	6	priming	prime	VERB
sb397656k5b	11	7	had	have	VERB
sb397656k5b	11	8	an	an	DET
sb397656k5b	11	9	inhibitory	inhibitory	ADJ
sb397656k5b	11	10	effect	effect	NOUN
sb397656k5b	11	11	on	on	ADP
sb397656k5b	11	12	chondrocyte	chondrocyte	NOUN
sb397656k5b	11	13	maturation	maturation	NOUN
sb397656k5b	11	14	,	,	PUNCT
sb397656k5b	11	15	consistent	consistent	ADJ
sb397656k5b	11	16	with	with	ADP
sb397656k5b	11	17	in	in	ADP
sb397656k5b	11	18	vivo	vivo	ADJ
sb397656k5b	11	19	findings	finding	NOUN
sb397656k5b	11	20	.	.	PUNCT
sb397656k5b	12	1	together	together	ADV
sb397656k5b	12	2	these	these	DET
sb397656k5b	12	3	results	result	NOUN
sb397656k5b	12	4	suggest	suggest	VERB
sb397656k5b	12	5	that	that	SCONJ
sb397656k5b	12	6	mechanical	mechanical	ADJ
sb397656k5b	12	7	loading	loading	NOUN
sb397656k5b	12	8	is	be	AUX
sb397656k5b	12	9	necessary	necessary	ADJ
sb397656k5b	12	10	to	to	PART
sb397656k5b	12	11	induce	induce	VERB
sb397656k5b	12	12	successful	successful	ADJ
sb397656k5b	12	13	endochondral	endochondral	ADJ
sb397656k5b	12	14	progression	progression	NOUN
sb397656k5b	12	15	for	for	ADP
sb397656k5b	12	16	bone	bone	NOUN
sb397656k5b	12	17	tissue	tissue	NOUN
sb397656k5b	12	18	engineering	engineering	NOUN
sb397656k5b	12	19	.	.	PUNCT