id	sid	tid	token	lemma	pos
s7526973296	1	1	i.	i.	PROPN
s7526973296	1	2	the	the	DET
s7526973296	1	3	effects	effect	NOUN
s7526973296	1	4	of	of	ADP
s7526973296	1	5	titanium	titanium	NOUN
s7526973296	1	6	dioxide	dioxide	NOUN
s7526973296	1	7	nanoparticles	nanoparticle	NOUN
s7526973296	1	8	on	on	ADP
s7526973296	1	9	cell	cell	NOUN
s7526973296	1	10	-	-	PUNCT
s7526973296	1	11	cell	cell	NOUN
s7526973296	1	12	contacts	contact	NOUN
s7526973296	1	13	during	during	ADP
s7526973296	1	14	xenopus	xenopus	PROPN
s7526973296	1	15	embryogenesis	embryogenesis	NOUN
s7526973296	1	16	titanium	titanium	NOUN
s7526973296	1	17	dioxide	dioxide	NOUN
s7526973296	1	18	nanoparticles	nanoparticle	NOUN
s7526973296	1	19	(	(	PUNCT
s7526973296	1	20	nps	nps	PROPN
s7526973296	1	21	)	)	PUNCT
s7526973296	1	22	,	,	PUNCT
s7526973296	1	23	previously	previously	ADV
s7526973296	1	24	considered	consider	VERB
s7526973296	1	25	inert	inert	ADV
s7526973296	1	26	,	,	PUNCT
s7526973296	1	27	are	be	AUX
s7526973296	1	28	semiconducting	semiconducte	VERB
s7526973296	1	29	nanomaterials	nanomaterial	NOUN
s7526973296	1	30	that	that	PRON
s7526973296	1	31	possess	possess	VERB
s7526973296	1	32	photocatalytic	photocatalytic	ADJ
s7526973296	1	33	activity	activity	NOUN
s7526973296	1	34	.	.	PUNCT
s7526973296	2	1	these	these	DET
s7526973296	2	2	nanoparticles	nanoparticle	NOUN
s7526973296	2	3	are	be	AUX
s7526973296	2	4	found	find	VERB
s7526973296	2	5	in	in	ADP
s7526973296	2	6	a	a	DET
s7526973296	2	7	variety	variety	NOUN
s7526973296	2	8	of	of	ADP
s7526973296	2	9	consumer	consumer	NOUN
s7526973296	2	10	products	product	NOUN
s7526973296	2	11	,	,	PUNCT
s7526973296	2	12	including	include	VERB
s7526973296	2	13	foods	food	NOUN
s7526973296	2	14	,	,	PUNCT
s7526973296	2	15	paper	paper	NOUN
s7526973296	2	16	,	,	PUNCT
s7526973296	2	17	paints	paint	NOUN
s7526973296	2	18	,	,	PUNCT
s7526973296	2	19	and	and	CCONJ
s7526973296	2	20	cosmetics	cosmetic	NOUN
s7526973296	2	21	.	.	PUNCT
s7526973296	3	1	however	however	ADV
s7526973296	3	2	,	,	PUNCT
s7526973296	3	3	few	few	ADJ
s7526973296	3	4	methods	method	NOUN
s7526973296	3	5	are	be	AUX
s7526973296	3	6	in	in	ADP
s7526973296	3	7	place	place	NOUN
s7526973296	3	8	to	to	PART
s7526973296	3	9	monitor	monitor	VERB
s7526973296	3	10	the	the	DET
s7526973296	3	11	safety	safety	NOUN
s7526973296	3	12	of	of	ADP
s7526973296	3	13	these	these	DET
s7526973296	3	14	products	product	NOUN
s7526973296	3	15	.	.	PUNCT
s7526973296	4	1	to	to	PART
s7526973296	4	2	study	study	VERB
s7526973296	4	3	the	the	DET
s7526973296	4	4	effects	effect	NOUN
s7526973296	4	5	of	of	ADP
s7526973296	4	6	tio2	tio2	NOUN
s7526973296	4	7	nps	nps	PROPN
s7526973296	4	8	on	on	ADP
s7526973296	4	9	embryonic	embryonic	ADJ
s7526973296	4	10	development	development	NOUN
s7526973296	4	11	,	,	PUNCT
s7526973296	4	12	precise	precise	ADJ
s7526973296	4	13	amounts	amount	NOUN
s7526973296	4	14	of	of	ADP
s7526973296	4	15	tio2	tio2	NOUN
s7526973296	4	16	nps	nps	PROPN
s7526973296	4	17	were	be	AUX
s7526973296	4	18	microinjected	microinjecte	VERB
s7526973296	4	19	into	into	ADP
s7526973296	4	20	xenopus	xenopus	PROPN
s7526973296	4	21	laevis	laevis	PROPN
s7526973296	4	22	embryos	embryos	PROPN
s7526973296	4	23	shortly	shortly	ADV
s7526973296	4	24	after	after	ADP
s7526973296	4	25	fertilization	fertilization	NOUN
s7526973296	4	26	to	to	PART
s7526973296	4	27	test	test	VERB
s7526973296	4	28	for	for	ADP
s7526973296	4	29	toxicity	toxicity	NOUN
s7526973296	4	30	.	.	PUNCT
s7526973296	5	1	these	these	DET
s7526973296	5	2	studies	study	NOUN
s7526973296	5	3	have	have	AUX
s7526973296	5	4	shown	show	VERB
s7526973296	5	5	that	that	SCONJ
s7526973296	5	6	tio2	tio2	PRON
s7526973296	5	7	nps	nps	PROPN
s7526973296	5	8	are	be	AUX
s7526973296	5	9	teratogenic	teratogenic	ADJ
s7526973296	5	10	and	and	CCONJ
s7526973296	5	11	compromise	compromise	NOUN
s7526973296	5	12	cell	cell	NOUN
s7526973296	5	13	-	-	PUNCT
s7526973296	5	14	cell	cell	NOUN
s7526973296	5	15	contacts	contact	NOUN
s7526973296	5	16	during	during	ADP
s7526973296	5	17	embryogenesis	embryogenesis	PROPN
s7526973296	5	18	.	.	PUNCT
s7526973296	6	1	a	a	DET
s7526973296	6	2	microarray	microarray	PROPN
s7526973296	6	3	analysis	analysis	NOUN
s7526973296	6	4	of	of	ADP
s7526973296	6	5	embryos	embryo	NOUN
s7526973296	6	6	injected	inject	VERB
s7526973296	6	7	with	with	ADP
s7526973296	6	8	tio2	tio2	NOUN
s7526973296	6	9	nps	nps	PROPN
s7526973296	6	10	indicated	indicate	VERB
s7526973296	6	11	a	a	DET
s7526973296	6	12	disruption	disruption	NOUN
s7526973296	6	13	of	of	ADP
s7526973296	6	14	genes	gene	NOUN
s7526973296	6	15	implicated	implicate	VERB
s7526973296	6	16	in	in	ADP
s7526973296	6	17	tight	tight	ADJ
s7526973296	6	18	junctions	junction	NOUN
s7526973296	6	19	(	(	PUNCT
s7526973296	6	20	occludin	occludin	ADJ
s7526973296	6	21	,	,	PUNCT
s7526973296	6	22	claudins	claudin	VERB
s7526973296	6	23	4	4	NUM
s7526973296	6	24	and	and	CCONJ
s7526973296	6	25	7	7	NUM
s7526973296	6	26	,	,	PUNCT
s7526973296	6	27	cadherin	cadherin	NOUN
s7526973296	6	28	26	26	NUM
s7526973296	6	29	)	)	PUNCT
s7526973296	6	30	,	,	PUNCT
s7526973296	6	31	cell	cell	NOUN
s7526973296	6	32	movement	movement	NOUN
s7526973296	6	33	(	(	PUNCT
s7526973296	6	34	calcipressin	calcipressin	PROPN
s7526973296	6	35	1	1	PROPN
s7526973296	6	36	,	,	PUNCT
s7526973296	6	37	rhoa	rhoa	PROPN
s7526973296	6	38	,	,	PUNCT
s7526973296	6	39	gαi	gαi	PROPN
s7526973296	6	40	)	)	PUNCT
s7526973296	6	41	,	,	PUNCT
s7526973296	6	42	and	and	CCONJ
s7526973296	6	43	cell	cell	NOUN
s7526973296	6	44	adhesion	adhesion	NOUN
s7526973296	6	45	(	(	PUNCT
s7526973296	6	46	ephrin	ephrin	ADJ
s7526973296	6	47	a1	a1	PROPN
s7526973296	6	48	,	,	PUNCT
s7526973296	6	49	rhoa	rhoa	PROPN
s7526973296	6	50	,	,	PUNCT
s7526973296	6	51	gαi	gαi	PROPN
s7526973296	6	52	)	)	PUNCT
s7526973296	6	53	.	.	PUNCT
s7526973296	7	1	western	western	ADJ
s7526973296	7	2	blot	blot	NOUN
s7526973296	7	3	analysis	analysis	NOUN
s7526973296	7	4	confirmed	confirm	VERB
s7526973296	7	5	decreased	decreased	ADJ
s7526973296	7	6	levels	level	NOUN
s7526973296	7	7	of	of	ADP
s7526973296	7	8	occludin	occludin	ADJ
s7526973296	7	9	in	in	ADP
s7526973296	7	10	embryos	embryo	NOUN
s7526973296	7	11	microinjected	microinjecte	VERB
s7526973296	7	12	with	with	ADP
s7526973296	7	13	tio2	tio2	PROPN
s7526973296	7	14	nps	nps	PROPN
s7526973296	7	15	.	.	PUNCT
s7526973296	8	1	confocal	confocal	ADJ
s7526973296	8	2	analysis	analysis	NOUN
s7526973296	8	3	of	of	ADP
s7526973296	8	4	these	these	DET
s7526973296	8	5	embryos	embryo	NOUN
s7526973296	8	6	also	also	ADV
s7526973296	8	7	confirmed	confirm	VERB
s7526973296	8	8	decreased	decreased	ADJ
s7526973296	8	9	levels	level	NOUN
s7526973296	8	10	of	of	ADP
s7526973296	8	11	occludin	occludin	ADJ
s7526973296	8	12	protein	protein	NOUN
s7526973296	8	13	and	and	CCONJ
s7526973296	8	14	increased	increase	VERB
s7526973296	8	15	levels	level	NOUN
s7526973296	8	16	of	of	ADP
s7526973296	8	17	ephrin	ephrin	NOUN
s7526973296	8	18	-	-	PUNCT
s7526973296	8	19	a1	a1	PROPN
s7526973296	8	20	in	in	ADP
s7526973296	8	21	the	the	DET
s7526973296	8	22	involuting	involute	VERB
s7526973296	8	23	ectoderm	ectoderm	NOUN
s7526973296	8	24	.	.	PUNCT
s7526973296	9	1	preliminary	preliminary	ADJ
s7526973296	9	2	studies	study	NOUN
s7526973296	9	3	suggest	suggest	VERB
s7526973296	9	4	that	that	SCONJ
s7526973296	9	5	actin	actin	NOUN
s7526973296	9	6	polymerization	polymerization	NOUN
s7526973296	9	7	is	be	AUX
s7526973296	9	8	increased	increase	VERB
s7526973296	9	9	in	in	ADP
s7526973296	9	10	embryos	embryo	NOUN
s7526973296	9	11	microinjected	microinjecte	VERB
s7526973296	9	12	with	with	ADP
s7526973296	9	13	tio2	tio2	PROPN
s7526973296	9	14	nps	nps	PROPN
s7526973296	9	15	.	.	PUNCT
s7526973296	10	1	in	in	ADP
s7526973296	10	2	line	line	NOUN
s7526973296	10	3	with	with	ADP
s7526973296	10	4	this	this	PRON
s7526973296	10	5	,	,	PUNCT
s7526973296	10	6	expression	expression	NOUN
s7526973296	10	7	of	of	ADP
s7526973296	10	8	rhoa	rhoa	NOUN
s7526973296	10	9	is	be	AUX
s7526973296	10	10	increased	increase	VERB
s7526973296	10	11	in	in	ADP
s7526973296	10	12	the	the	DET
s7526973296	10	13	microarray	microarray	PROPN
s7526973296	10	14	data	data	PROPN
s7526973296	10	15	,	,	PUNCT
s7526973296	10	16	and	and	CCONJ
s7526973296	10	17	activated	activate	VERB
s7526973296	10	18	rhoa	rhoa	NOUN
s7526973296	10	19	promotes	promote	VERB
s7526973296	10	20	actin	actin	NOUN
s7526973296	10	21	polymerization	polymerization	NOUN
s7526973296	10	22	and	and	CCONJ
s7526973296	10	23	contraction	contraction	NOUN
s7526973296	10	24	.	.	PUNCT
s7526973296	11	1	disruption	disruption	NOUN
s7526973296	11	2	in	in	ADP
s7526973296	11	3	signaling	signal	VERB
s7526973296	11	4	pathways	pathway	NOUN
s7526973296	11	5	involving	involve	VERB
s7526973296	11	6	these	these	DET
s7526973296	11	7	proteins	protein	NOUN
s7526973296	11	8	could	could	AUX
s7526973296	11	9	account	account	VERB
s7526973296	11	10	for	for	ADP
s7526973296	11	11	the	the	DET
s7526973296	11	12	phenotypes	phenotype	NOUN
s7526973296	11	13	observed	observe	VERB
s7526973296	11	14	in	in	ADP
s7526973296	11	15	the	the	DET
s7526973296	11	16	tio2	tio2	NOUN
s7526973296	11	17	nps	nps	PROPN
s7526973296	11	18	injected	inject	VERB
s7526973296	11	19	embryos	embryo	NOUN
s7526973296	11	20	.	.	PUNCT
s7526973296	12	1	this	this	DET
s7526973296	12	2	research	research	NOUN
s7526973296	12	3	highlights	highlight	VERB
s7526973296	12	4	the	the	DET
s7526973296	12	5	need	need	NOUN
s7526973296	12	6	for	for	ADP
s7526973296	12	7	an	an	DET
s7526973296	12	8	increased	increase	VERB
s7526973296	12	9	understanding	understanding	NOUN
s7526973296	12	10	of	of	ADP
s7526973296	12	11	the	the	DET
s7526973296	12	12	bioactivity	bioactivity	NOUN
s7526973296	12	13	of	of	ADP
s7526973296	12	14	tio2	tio2	PROPN
s7526973296	12	15	nps	nps	PROPN
s7526973296	12	16	.	.	PUNCT
s7526973296	13	1	ii	ii	PROPN
s7526973296	13	2	.	.	PROPN
s7526973296	13	3	targeted	target	VERB
s7526973296	13	4	depletion	depletion	NOUN
s7526973296	13	5	of	of	ADP
s7526973296	13	6	sumoylation	sumoylation	NOUN
s7526973296	13	7	in	in	ADP
s7526973296	13	8	cardiomyocytes	cardiomyocyte	NOUN
s7526973296	13	9	of	of	ADP
s7526973296	13	10	xenopus	xenopus	PROPN
s7526973296	13	11	embryoschds	embryoschds	PROPN
s7526973296	13	12	are	be	AUX
s7526973296	13	13	the	the	DET
s7526973296	13	14	most	most	ADV
s7526973296	13	15	common	common	ADJ
s7526973296	13	16	form	form	NOUN
s7526973296	13	17	of	of	ADP
s7526973296	13	18	human	human	ADJ
s7526973296	13	19	birth	birth	NOUN
s7526973296	13	20	defect	defect	NOUN
s7526973296	13	21	with	with	ADP
s7526973296	13	22	36,000	36,000	NUM
s7526973296	13	23	american	american	ADJ
s7526973296	13	24	births	birth	NOUN
s7526973296	13	25	and	and	CCONJ
s7526973296	13	26	~1	~1	NUM
s7526973296	13	27	%	%	NOUN
s7526973296	13	28	of	of	ADP
s7526973296	13	29	worldwide	worldwide	ADJ
s7526973296	13	30	births	birth	NOUN
s7526973296	13	31	affected	affect	VERB
s7526973296	13	32	each	each	DET
s7526973296	13	33	year	year	NOUN
s7526973296	13	34	.	.	PUNCT
s7526973296	14	1	chds	chds	PROPN
s7526973296	14	2	also	also	ADV
s7526973296	14	3	account	account	VERB
s7526973296	14	4	for	for	ADP
s7526973296	14	5	more	more	ADJ
s7526973296	14	6	infant	infant	NOUN
s7526973296	14	7	deaths	death	NOUN
s7526973296	14	8	during	during	ADP
s7526973296	14	9	the	the	DET
s7526973296	14	10	first	first	ADJ
s7526973296	14	11	year	year	NOUN
s7526973296	14	12	of	of	ADP
s7526973296	14	13	life	life	NOUN
s7526973296	14	14	than	than	ADP
s7526973296	14	15	any	any	DET
s7526973296	14	16	other	other	ADJ
s7526973296	14	17	birth	birth	NOUN
s7526973296	14	18	defect	defect	NOUN
s7526973296	14	19	.	.	PUNCT
s7526973296	15	1	however	however	ADV
s7526973296	15	2	,	,	PUNCT
s7526973296	15	3	genetic	genetic	ADJ
s7526973296	15	4	inheritance	inheritance	NOUN
s7526973296	15	5	can	can	AUX
s7526973296	15	6	only	only	ADV
s7526973296	15	7	explain	explain	VERB
s7526973296	15	8	a	a	DET
s7526973296	15	9	small	small	ADJ
s7526973296	15	10	percentage	percentage	NOUN
s7526973296	15	11	of	of	ADP
s7526973296	15	12	chds	chds	PROPN
s7526973296	15	13	,	,	PUNCT
s7526973296	15	14	leaving	leave	VERB
s7526973296	15	15	the	the	DET
s7526973296	15	16	cause	cause	NOUN
s7526973296	15	17	for	for	ADP
s7526973296	15	18	the	the	DET
s7526973296	15	19	majority	majority	NOUN
s7526973296	15	20	of	of	ADP
s7526973296	15	21	abnormalities	abnormality	NOUN
s7526973296	15	22	unknown	unknown	ADJ
s7526973296	15	23	.	.	PUNCT
s7526973296	16	1	several	several	ADJ
s7526973296	16	2	transcription	transcription	NOUN
s7526973296	16	3	factors	factor	NOUN
s7526973296	16	4	that	that	PRON
s7526973296	16	5	are	be	AUX
s7526973296	16	6	critical	critical	ADJ
s7526973296	16	7	for	for	ADP
s7526973296	16	8	normal	normal	ADJ
s7526973296	16	9	heart	heart	NOUN
s7526973296	16	10	development	development	NOUN
s7526973296	16	11	are	be	AUX
s7526973296	16	12	modified	modify	VERB
s7526973296	16	13	by	by	ADP
s7526973296	16	14	sumoylation	sumoylation	NOUN
s7526973296	16	15	.	.	PUNCT
s7526973296	17	1	additionally	additionally	ADV
s7526973296	17	2	,	,	PUNCT
s7526973296	17	3	there	there	PRON
s7526973296	17	4	are	be	VERB
s7526973296	17	5	many	many	ADJ
s7526973296	17	6	examples	example	NOUN
s7526973296	17	7	where	where	SCONJ
s7526973296	17	8	sumoylation	sumoylation	NOUN
s7526973296	17	9	is	be	AUX
s7526973296	17	10	critical	critical	ADJ
s7526973296	17	11	for	for	ADP
s7526973296	17	12	normal	normal	ADJ
s7526973296	17	13	cardiovascular	cardiovascular	ADJ
s7526973296	17	14	development	development	NOUN
s7526973296	17	15	and	and	CCONJ
s7526973296	17	16	function	function	NOUN
s7526973296	17	17	.	.	PUNCT
s7526973296	18	1	sumoylation	sumoylation	NOUN
s7526973296	18	2	,	,	PUNCT
s7526973296	18	3	a	a	DET
s7526973296	18	4	post	post	ADJ
s7526973296	18	5	-	-	ADJ
s7526973296	18	6	translational	translational	ADJ
s7526973296	18	7	modification	modification	NOUN
s7526973296	18	8	that	that	PRON
s7526973296	18	9	occurs	occur	VERB
s7526973296	18	10	via	via	ADP
s7526973296	18	11	an	an	DET
s7526973296	18	12	enzymatic	enzymatic	ADJ
s7526973296	18	13	cascade	cascade	NOUN
s7526973296	18	14	,	,	PUNCT
s7526973296	18	15	affects	affect	VERB
s7526973296	18	16	a	a	DET
s7526973296	18	17	variety	variety	NOUN
s7526973296	18	18	of	of	ADP
s7526973296	18	19	biological	biological	ADJ
s7526973296	18	20	processes	process	NOUN
s7526973296	18	21	.	.	PUNCT
s7526973296	19	1	transcription	transcription	NOUN
s7526973296	19	2	factors	factor	NOUN
s7526973296	19	3	are	be	AUX
s7526973296	19	4	a	a	DET
s7526973296	19	5	frequent	frequent	ADJ
s7526973296	19	6	target	target	NOUN
s7526973296	19	7	of	of	ADP
s7526973296	19	8	sumoylation	sumoylation	NOUN
s7526973296	19	9	,	,	PUNCT
s7526973296	19	10	and	and	CCONJ
s7526973296	19	11	this	this	DET
s7526973296	19	12	reversible	reversible	ADJ
s7526973296	19	13	modification	modification	NOUN
s7526973296	19	14	plays	play	VERB
s7526973296	19	15	a	a	DET
s7526973296	19	16	significant	significant	ADJ
s7526973296	19	17	role	role	NOUN
s7526973296	19	18	in	in	ADP
s7526973296	19	19	regulation	regulation	NOUN
s7526973296	19	20	of	of	ADP
s7526973296	19	21	gene	gene	NOUN
s7526973296	19	22	expression	expression	NOUN
s7526973296	19	23	.	.	PUNCT
s7526973296	20	1	expression	expression	NOUN
s7526973296	20	2	of	of	ADP
s7526973296	20	3	gam1	gam1	PROPN
s7526973296	20	4	,	,	PUNCT
s7526973296	20	5	an	an	DET
s7526973296	20	6	adenoviral	adenoviral	ADJ
s7526973296	20	7	protein	protein	NOUN
s7526973296	20	8	that	that	PRON
s7526973296	20	9	degrades	degrade	VERB
s7526973296	20	10	the	the	DET
s7526973296	20	11	sumo	sumo	ADJ
s7526973296	20	12	e1	e1	PROPN
s7526973296	20	13	-	-	PUNCT
s7526973296	20	14	activating	activate	VERB
s7526973296	20	15	enzyme	enzyme	NOUN
s7526973296	20	16	,	,	PUNCT
s7526973296	20	17	was	be	AUX
s7526973296	20	18	placed	place	VERB
s7526973296	20	19	under	under	ADP
s7526973296	20	20	the	the	DET
s7526973296	20	21	control	control	NOUN
s7526973296	20	22	of	of	ADP
s7526973296	20	23	three	three	NUM
s7526973296	20	24	cardiac	cardiac	ADJ
s7526973296	20	25	specific	specific	ADJ
s7526973296	20	26	promoters	promoter	NOUN
s7526973296	20	27	(	(	PUNCT
s7526973296	20	28	nkx2.5	nkx2.5	PROPN
s7526973296	20	29	,	,	PUNCT
s7526973296	20	30	mlc2	mlc2	NOUN
s7526973296	20	31	,	,	PUNCT
s7526973296	20	32	and	and	CCONJ
s7526973296	20	33	anf	anf	INTJ
s7526973296	20	34	)	)	PUNCT
s7526973296	20	35	,	,	PUNCT
s7526973296	20	36	in	in	ADP
s7526973296	20	37	order	order	NOUN
s7526973296	20	38	to	to	PART
s7526973296	20	39	reduce	reduce	VERB
s7526973296	20	40	sumoylation	sumoylation	NOUN
s7526973296	20	41	in	in	ADP
s7526973296	20	42	cardiac	cardiac	ADJ
s7526973296	20	43	progenitor	progenitor	NOUN
s7526973296	20	44	cells	cell	NOUN
s7526973296	20	45	at	at	ADP
s7526973296	20	46	distinct	distinct	ADJ
s7526973296	20	47	embryonic	embryonic	ADJ
s7526973296	20	48	stages	stage	NOUN
s7526973296	20	49	.	.	PUNCT
s7526973296	21	1	results	result	NOUN
s7526973296	21	2	indicate	indicate	VERB
s7526973296	21	3	that	that	DET
s7526973296	21	4	reduction	reduction	NOUN
s7526973296	21	5	of	of	ADP
s7526973296	21	6	sumoylation	sumoylation	NOUN
s7526973296	21	7	activity	activity	NOUN
s7526973296	21	8	causes	cause	VERB
s7526973296	21	9	a	a	DET
s7526973296	21	10	variety	variety	NOUN
s7526973296	21	11	of	of	ADP
s7526973296	21	12	cardiac	cardiac	ADJ
s7526973296	21	13	malformations	malformation	NOUN
s7526973296	21	14	,	,	PUNCT
s7526973296	21	15	including	include	VERB
s7526973296	21	16	ventricular	ventricular	ADJ
s7526973296	21	17	noncompaction	noncompaction	NOUN
s7526973296	21	18	cardiomyopathy	cardiomyopathy	PROPN
s7526973296	21	19	,	,	PUNCT
s7526973296	21	20	cardiac	cardiac	ADJ
s7526973296	21	21	edema	edema	NOUN
s7526973296	21	22	,	,	PUNCT
s7526973296	21	23	reversal	reversal	NOUN
s7526973296	21	24	of	of	ADP
s7526973296	21	25	cardiac	cardiac	ADJ
s7526973296	21	26	laterality	laterality	NOUN
s7526973296	21	27	,	,	PUNCT
s7526973296	21	28	failure	failure	NOUN
s7526973296	21	29	of	of	ADP
s7526973296	21	30	looping	looping	NOUN
s7526973296	21	31	morphogenesis	morphogenesis	NOUN
s7526973296	21	32	,	,	PUNCT
s7526973296	21	33	failure	failure	NOUN
s7526973296	21	34	of	of	ADP
s7526973296	21	35	fusion	fusion	NOUN
s7526973296	21	36	of	of	ADP
s7526973296	21	37	cardiac	cardiac	ADJ
s7526973296	21	38	heart	heart	NOUN
s7526973296	21	39	fields	field	NOUN
s7526973296	21	40	,	,	PUNCT
s7526973296	21	41	and	and	CCONJ
s7526973296	21	42	decreased	decrease	VERB
s7526973296	21	43	cardiomyocyte	cardiomyocyte	ADJ
s7526973296	21	44	proliferation	proliferation	NOUN
s7526973296	21	45	.	.	PUNCT
s7526973296	22	1	the	the	DET
s7526973296	22	2	occurrence	occurrence	NOUN
s7526973296	22	3	of	of	ADP
s7526973296	22	4	these	these	DET
s7526973296	22	5	phenotypes	phenotype	NOUN
s7526973296	22	6	varied	varied	ADJ
s7526973296	22	7	according	accord	VERB
s7526973296	22	8	to	to	ADP
s7526973296	22	9	the	the	DET
s7526973296	22	10	cardiac	cardiac	ADJ
s7526973296	22	11	promoter	promoter	NOUN
s7526973296	22	12	controlling	control	VERB
s7526973296	22	13	expression	expression	NOUN
s7526973296	22	14	of	of	ADP
s7526973296	22	15	the	the	DET
s7526973296	22	16	transgene	transgene	NOUN
s7526973296	22	17	.	.	PUNCT
s7526973296	23	1	embryos	embryo	NOUN
s7526973296	23	2	expressing	express	VERB
s7526973296	23	3	gam1	gam1	NOUN
s7526973296	23	4	under	under	ADP
s7526973296	23	5	control	control	NOUN
s7526973296	23	6	of	of	ADP
s7526973296	23	7	the	the	DET
s7526973296	23	8	nkx2.5b	nkx2.5b	PROPN
s7526973296	23	9	promoter	promoter	NOUN
s7526973296	23	10	exhibited	exhibit	VERB
s7526973296	23	11	a	a	DET
s7526973296	23	12	high	high	ADJ
s7526973296	23	13	occurrence	occurrence	NOUN
s7526973296	23	14	of	of	ADP
s7526973296	23	15	outflow	outflow	NOUN
s7526973296	23	16	tract	tract	NOUN
s7526973296	23	17	and	and	CCONJ
s7526973296	23	18	atrial	atrial	ADJ
s7526973296	23	19	defects	defect	NOUN
s7526973296	23	20	.	.	PUNCT
s7526973296	24	1	on	on	ADP
s7526973296	24	2	the	the	DET
s7526973296	24	3	other	other	ADJ
s7526973296	24	4	hand	hand	NOUN
s7526973296	24	5	,	,	PUNCT
s7526973296	24	6	embryos	embryo	NOUN
s7526973296	24	7	expressing	express	VERB
s7526973296	24	8	gam1	gam1	NOUN
s7526973296	24	9	under	under	ADP
s7526973296	24	10	control	control	NOUN
s7526973296	24	11	of	of	ADP
s7526973296	24	12	the	the	DET
s7526973296	24	13	anf	anf	PROPN
s7526973296	24	14	promoter	promoter	NOUN
s7526973296	24	15	exhibited	exhibit	VERB
s7526973296	24	16	a	a	DET
s7526973296	24	17	high	high	ADJ
s7526973296	24	18	occurrence	occurrence	NOUN
s7526973296	24	19	of	of	ADP
s7526973296	24	20	atrial	atrial	ADJ
s7526973296	24	21	septal	septal	ADJ
s7526973296	24	22	defects	defect	NOUN
s7526973296	24	23	.	.	PUNCT
s7526973296	25	1	surprisingly	surprisingly	ADV
s7526973296	25	2	,	,	PUNCT
s7526973296	25	3	embryos	embryo	NOUN
s7526973296	25	4	expressing	express	VERB
s7526973296	25	5	gam1	gam1	NOUN
s7526973296	25	6	under	under	ADP
s7526973296	25	7	control	control	NOUN
s7526973296	25	8	of	of	ADP
s7526973296	25	9	the	the	DET
s7526973296	25	10	mlc2	mlc2	ADJ
s7526973296	25	11	promoter	promoter	NOUN
s7526973296	25	12	were	be	AUX
s7526973296	25	13	least	least	ADV
s7526973296	25	14	affected	affect	VERB
s7526973296	25	15	by	by	ADP
s7526973296	25	16	loss	loss	NOUN
s7526973296	25	17	of	of	ADP
s7526973296	25	18	sumoylation	sumoylation	NOUN
s7526973296	25	19	,	,	PUNCT
s7526973296	25	20	with	with	ADP
s7526973296	25	21	most	most	ADJ
s7526973296	25	22	defects	defect	NOUN
s7526973296	25	23	being	be	AUX
s7526973296	25	24	moderate	moderate	ADJ
s7526973296	25	25	in	in	ADP
s7526973296	25	26	nature	nature	NOUN
s7526973296	25	27	and	and	CCONJ
s7526973296	25	28	involving	involve	VERB
s7526973296	25	29	the	the	DET
s7526973296	25	30	atrial	atrial	ADJ
s7526973296	25	31	septal	septal	ADJ
s7526973296	25	32	wall	wall	NOUN
s7526973296	25	33	.	.	PUNCT
s7526973296	26	1	these	these	DET
s7526973296	26	2	studies	study	NOUN
s7526973296	26	3	shed	shed	VERB
s7526973296	26	4	light	light	NOUN
s7526973296	26	5	on	on	ADP
s7526973296	26	6	the	the	DET
s7526973296	26	7	molecular	molecular	ADJ
s7526973296	26	8	mechanisms	mechanism	NOUN
s7526973296	26	9	underlying	underlie	VERB
s7526973296	26	10	congenital	congenital	ADJ
s7526973296	26	11	heart	heart	NOUN
s7526973296	26	12	defects	defect	NOUN
s7526973296	26	13	in	in	ADP
s7526973296	26	14	humans	human	NOUN
s7526973296	26	15	and	and	CCONJ
s7526973296	26	16	provide	provide	VERB
s7526973296	26	17	potential	potential	ADJ
s7526973296	26	18	therapeutic	therapeutic	ADJ
s7526973296	26	19	targets	target	NOUN
s7526973296	26	20	to	to	PART
s7526973296	26	21	prevent	prevent	VERB
s7526973296	26	22	the	the	DET
s7526973296	26	23	occurrence	occurrence	NOUN
s7526973296	26	24	of	of	ADP
s7526973296	26	25	these	these	DET
s7526973296	26	26	malformations	malformation	NOUN
s7526973296	26	27	.	.	PUNCT