id sid tid token lemma pos s4655d8949g 1 1 bone bone NOUN s4655d8949g 1 2 adapts adapt VERB s4655d8949g 1 3 to to ADP s4655d8949g 1 4 mechanical mechanical ADJ s4655d8949g 1 5 loading loading NOUN s4655d8949g 1 6 through through ADP s4655d8949g 1 7 the the DET s4655d8949g 1 8 coordination coordination NOUN s4655d8949g 1 9 of of ADP s4655d8949g 1 10 many many ADJ s4655d8949g 1 11 cell cell NOUN s4655d8949g 1 12 types type NOUN s4655d8949g 1 13 including include VERB s4655d8949g 1 14 osteocytes osteocyte NOUN s4655d8949g 1 15 , , PUNCT s4655d8949g 1 16 osteoblasts osteoblast NOUN s4655d8949g 1 17 , , PUNCT s4655d8949g 1 18 osteoclasts osteoclast NOUN s4655d8949g 1 19 , , PUNCT s4655d8949g 1 20 and and CCONJ s4655d8949g 1 21 stem stem NOUN s4655d8949g 1 22 cells cell NOUN s4655d8949g 1 23 . . PUNCT s4655d8949g 2 1 these these DET s4655d8949g 2 2 cells cell NOUN s4655d8949g 2 3 sense sense VERB s4655d8949g 2 4 mechanical mechanical ADJ s4655d8949g 2 5 loading loading NOUN s4655d8949g 2 6 and and CCONJ s4655d8949g 2 7 carry carry VERB s4655d8949g 2 8 out out ADP s4655d8949g 2 9 biochemical biochemical ADJ s4655d8949g 2 10 signaling signaling NOUN s4655d8949g 2 11 in in ADP s4655d8949g 2 12 a a DET s4655d8949g 2 13 process process NOUN s4655d8949g 2 14 known know VERB s4655d8949g 2 15 as as ADP s4655d8949g 2 16 mechanotransduction mechanotransduction NOUN s4655d8949g 2 17 . . PUNCT s4655d8949g 3 1 while while SCONJ s4655d8949g 3 2 it it PRON s4655d8949g 3 3 is be AUX s4655d8949g 3 4 understood understand VERB s4655d8949g 3 5 that that SCONJ s4655d8949g 3 6 mechanotransduction mechanotransduction NOUN s4655d8949g 3 7 drives drive VERB s4655d8949g 3 8 bone bone NOUN s4655d8949g 3 9 adaptation adaptation NOUN s4655d8949g 3 10 , , PUNCT s4655d8949g 3 11 the the DET s4655d8949g 3 12 mechanisms mechanism NOUN s4655d8949g 3 13 responsible responsible ADJ s4655d8949g 3 14 for for ADP s4655d8949g 3 15 mechanotransduction mechanotransduction NOUN s4655d8949g 3 16 are be AUX s4655d8949g 3 17 not not PART s4655d8949g 3 18 well well ADV s4655d8949g 3 19 understood understand VERB s4655d8949g 3 20 . . PUNCT s4655d8949g 4 1 the the DET s4655d8949g 4 2 goal goal NOUN s4655d8949g 4 3 of of ADP s4655d8949g 4 4 this this DET s4655d8949g 4 5 work work NOUN s4655d8949g 4 6 was be AUX s4655d8949g 4 7 to to PART s4655d8949g 4 8 gain gain VERB s4655d8949g 4 9 new new ADJ s4655d8949g 4 10 understandings understanding NOUN s4655d8949g 4 11 of of ADP s4655d8949g 4 12 mechanobiological mechanobiological ADJ s4655d8949g 4 13 signaling signaling NOUN s4655d8949g 4 14 in in ADP s4655d8949g 4 15 bone bone NOUN s4655d8949g 4 16 . . PUNCT s4655d8949g 5 1 in in ADP s4655d8949g 5 2 order order NOUN s4655d8949g 5 3 to to PART s4655d8949g 5 4 achieve achieve VERB s4655d8949g 5 5 this this PRON s4655d8949g 5 6 , , PUNCT s4655d8949g 5 7 the the DET s4655d8949g 5 8 effects effect NOUN s4655d8949g 5 9 of of ADP s4655d8949g 5 10 low low ADJ s4655d8949g 5 11 magnitude magnitude NOUN s4655d8949g 5 12 mechanical mechanical ADJ s4655d8949g 5 13 stimulation stimulation NOUN s4655d8949g 5 14 , , PUNCT s4655d8949g 5 15 a a DET s4655d8949g 5 16 loading loading NOUN s4655d8949g 5 17 regime regime NOUN s4655d8949g 5 18 that that PRON s4655d8949g 5 19 stimulates stimulate VERB s4655d8949g 5 20 bone bone NOUN s4655d8949g 5 21 formation formation NOUN s4655d8949g 5 22 in in ADP s4655d8949g 5 23 the the DET s4655d8949g 5 24 absence absence NOUN s4655d8949g 5 25 of of ADP s4655d8949g 5 26 significant significant ADJ s4655d8949g 5 27 matrix matrix NOUN s4655d8949g 5 28 strain strain NOUN s4655d8949g 5 29 , , PUNCT s4655d8949g 5 30 on on ADP s4655d8949g 5 31 trabecular trabecular ADJ s4655d8949g 5 32 bone bone NOUN s4655d8949g 5 33 and and CCONJ s4655d8949g 5 34 bone bone NOUN s4655d8949g 5 35 marrow marrow NOUN s4655d8949g 5 36 were be AUX s4655d8949g 5 37 investigated.computational investigated.computational ADJ s4655d8949g 5 38 fluid fluid ADJ s4655d8949g 5 39 dynamics dynamic NOUN s4655d8949g 5 40 models model NOUN s4655d8949g 5 41 quantified quantify VERB s4655d8949g 5 42 the the DET s4655d8949g 5 43 marrow marrow NOUN s4655d8949g 5 44 shear shear NOUN s4655d8949g 5 45 stresses stress NOUN s4655d8949g 5 46 occurring occur VERB s4655d8949g 5 47 during during ADP s4655d8949g 5 48 lmms lmms PROPN s4655d8949g 5 49 and and CCONJ s4655d8949g 5 50 demonstrated demonstrate VERB s4655d8949g 5 51 that that SCONJ s4655d8949g 5 52 marrow marrow NOUN s4655d8949g 5 53 is be AUX s4655d8949g 5 54 subject subject ADJ s4655d8949g 5 55 to to ADP s4655d8949g 5 56 shear shear ADJ s4655d8949g 5 57 stresses stress NOUN s4655d8949g 5 58 above above ADP s4655d8949g 5 59 a a DET s4655d8949g 5 60 mechanostimulatory mechanostimulatory ADJ s4655d8949g 5 61 shear shear ADJ s4655d8949g 5 62 stress stress NOUN s4655d8949g 5 63 . . PUNCT s4655d8949g 6 1 in in ADP s4655d8949g 6 2 order order NOUN s4655d8949g 6 3 to to PART s4655d8949g 6 4 exploit exploit VERB s4655d8949g 6 5 this this DET s4655d8949g 6 6 stimulatory stimulatory ADJ s4655d8949g 6 7 regime regime NOUN s4655d8949g 6 8 , , PUNCT s4655d8949g 6 9 trabecular trabecular ADJ s4655d8949g 6 10 bone bone NOUN s4655d8949g 6 11 explant explant NOUN s4655d8949g 6 12 bioreactors bioreactor NOUN s4655d8949g 6 13 were be AUX s4655d8949g 6 14 designed design VERB s4655d8949g 6 15 and and CCONJ s4655d8949g 6 16 validated validate VERB s4655d8949g 6 17 . . PUNCT s4655d8949g 7 1 these these DET s4655d8949g 7 2 bioreactors bioreactor NOUN s4655d8949g 7 3 supported support VERB s4655d8949g 7 4 active active ADJ s4655d8949g 7 5 bone bone NOUN s4655d8949g 7 6 remodeling remodel VERB s4655d8949g 7 7 with with ADP s4655d8949g 7 8 a a DET s4655d8949g 7 9 heterogeneous heterogeneous ADJ s4655d8949g 7 10 cell cell NOUN s4655d8949g 7 11 population population NOUN s4655d8949g 7 12 that that PRON s4655d8949g 7 13 experienced experience VERB s4655d8949g 7 14 mechanical mechanical ADJ s4655d8949g 7 15 stimuli stimulus NOUN s4655d8949g 7 16 that that PRON s4655d8949g 7 17 affected affect VERB s4655d8949g 7 18 bone bone NOUN s4655d8949g 7 19 formation formation NOUN s4655d8949g 7 20 . . PUNCT s4655d8949g 8 1 before before SCONJ s4655d8949g 8 2 mechanobiology mechanobiology PROPN s4655d8949g 8 3 of of ADP s4655d8949g 8 4 bone bone NOUN s4655d8949g 8 5 marrow marrow NOUN s4655d8949g 8 6 could could AUX s4655d8949g 8 7 be be AUX s4655d8949g 8 8 studied study VERB s4655d8949g 8 9 , , PUNCT s4655d8949g 8 10 osteocyte osteocyte ADJ s4655d8949g 8 11 signaling signal VERB s4655d8949g 8 12 during during ADP s4655d8949g 8 13 lmms lmms PROPN s4655d8949g 8 14 was be AUX s4655d8949g 8 15 determined determine VERB s4655d8949g 8 16 . . PUNCT s4655d8949g 9 1 their their PRON s4655d8949g 9 2 role role NOUN s4655d8949g 9 3 in in ADP s4655d8949g 9 4 mechanosensing mechanosensing NOUN s4655d8949g 9 5 of of ADP s4655d8949g 9 6 lmms lmms PROPN s4655d8949g 9 7 was be AUX s4655d8949g 9 8 investigated investigate VERB s4655d8949g 9 9 by by ADP s4655d8949g 9 10 quantifying quantify VERB s4655d8949g 9 11 the the DET s4655d8949g 9 12 percentage percentage NOUN s4655d8949g 9 13 of of ADP s4655d8949g 9 14 osteocytes osteocyte NOUN s4655d8949g 9 15 expressing express VERB s4655d8949g 9 16 sclerostin sclerostin PROPN s4655d8949g 9 17 , , PUNCT s4655d8949g 9 18 a a DET s4655d8949g 9 19 potent potent ADJ s4655d8949g 9 20 wnt wnt PROPN s4655d8949g 9 21 inhibitor inhibitor NOUN s4655d8949g 9 22 , , PUNCT s4655d8949g 9 23 with with ADP s4655d8949g 9 24 and and CCONJ s4655d8949g 9 25 without without ADP s4655d8949g 9 26 mechanical mechanical ADJ s4655d8949g 9 27 stimulation stimulation NOUN s4655d8949g 9 28 using use VERB s4655d8949g 9 29 bioreactor bioreactor NOUN s4655d8949g 9 30 culture culture NOUN s4655d8949g 9 31 . . PUNCT s4655d8949g 10 1 the the DET s4655d8949g 10 2 percentage percentage NOUN s4655d8949g 10 3 of of ADP s4655d8949g 10 4 sclerostin sclerostin ADJ s4655d8949g 10 5 positive positive ADJ s4655d8949g 10 6 osteocytes osteocyte NOUN s4655d8949g 10 7 did do AUX s4655d8949g 10 8 not not PART s4655d8949g 10 9 change change VERB s4655d8949g 10 10 in in ADP s4655d8949g 10 11 response response NOUN s4655d8949g 10 12 to to ADP s4655d8949g 10 13 culture culture NOUN s4655d8949g 10 14 or or CCONJ s4655d8949g 10 15 lmms lmms PROPN s4655d8949g 10 16 . . PUNCT s4655d8949g 11 1 this this DET s4655d8949g 11 2 result result NOUN s4655d8949g 11 3 suggests suggest VERB s4655d8949g 11 4 that that SCONJ s4655d8949g 11 5 sclerostin sclerostin PROPN s4655d8949g 11 6 signaling signaling NOUN s4655d8949g 11 7 is be AUX s4655d8949g 11 8 dependent dependent ADJ s4655d8949g 11 9 on on ADP s4655d8949g 11 10 matrix matrix NOUN s4655d8949g 11 11 strain strain NOUN s4655d8949g 11 12 and and CCONJ s4655d8949g 11 13 osteocytes osteocyte NOUN s4655d8949g 11 14 may may AUX s4655d8949g 11 15 not not PART s4655d8949g 11 16 be be AUX s4655d8949g 11 17 responsible responsible ADJ s4655d8949g 11 18 for for ADP s4655d8949g 11 19 mechanotransduction mechanotransduction NOUN s4655d8949g 11 20 during during ADP s4655d8949g 11 21 lmms lmms PROPN s4655d8949g 11 22 . . PUNCT s4655d8949g 12 1 to to PART s4655d8949g 12 2 investigate investigate VERB s4655d8949g 12 3 marrow marrow NOUN s4655d8949g 12 4 mechanobiology mechanobiology NOUN s4655d8949g 12 5 , , PUNCT s4655d8949g 12 6 the the DET s4655d8949g 12 7 presence presence NOUN s4655d8949g 12 8 of of ADP s4655d8949g 12 9 primary primary ADJ s4655d8949g 12 10 cilia cilia PROPN s4655d8949g 12 11 , , PUNCT s4655d8949g 12 12 a a DET s4655d8949g 12 13 potent potent ADJ s4655d8949g 12 14 mechanosensor mechanosensor NOUN s4655d8949g 12 15 , , PUNCT s4655d8949g 12 16 in in ADP s4655d8949g 12 17 the the DET s4655d8949g 12 18 trabecular trabecular ADJ s4655d8949g 12 19 bone bone NOUN s4655d8949g 12 20 compartment compartment NOUN s4655d8949g 12 21 was be AUX s4655d8949g 12 22 quantified quantify VERB s4655d8949g 12 23 before before ADP s4655d8949g 12 24 and and CCONJ s4655d8949g 12 25 after after ADP s4655d8949g 12 26 lmms lmms PROPN s4655d8949g 12 27 . . PUNCT s4655d8949g 13 1 they they PRON s4655d8949g 13 2 were be AUX s4655d8949g 13 3 present present ADJ s4655d8949g 13 4 on on ADP s4655d8949g 13 5 a a DET s4655d8949g 13 6 small small ADJ s4655d8949g 13 7 fraction fraction NOUN s4655d8949g 13 8 of of ADP s4655d8949g 13 9 bone bone NOUN s4655d8949g 13 10 marrow marrow NOUN s4655d8949g 13 11 cells cell NOUN s4655d8949g 13 12 and and CCONJ s4655d8949g 13 13 osteocytes osteocyte NOUN s4655d8949g 13 14 , , PUNCT s4655d8949g 13 15 and and CCONJ s4655d8949g 13 16 were be AUX s4655d8949g 13 17 relatively relatively ADV s4655d8949g 13 18 short short ADJ s4655d8949g 13 19 within within ADP s4655d8949g 13 20 the the DET s4655d8949g 13 21 trabecular trabecular ADJ s4655d8949g 13 22 bone bone NOUN s4655d8949g 13 23 and and CCONJ s4655d8949g 13 24 marrow marrow NOUN s4655d8949g 13 25 compartment compartment NOUN s4655d8949g 13 26 , , PUNCT s4655d8949g 13 27 indicating indicate VERB s4655d8949g 13 28 that that SCONJ s4655d8949g 13 29 they they PRON s4655d8949g 13 30 may may AUX s4655d8949g 13 31 function function VERB s4655d8949g 13 32 as as ADP s4655d8949g 13 33 mechanosensors mechanosensor NOUN s4655d8949g 13 34 in in ADP s4655d8949g 13 35 concert concert NOUN s4655d8949g 13 36 with with ADP s4655d8949g 13 37 other other ADJ s4655d8949g 13 38 mechanosensors mechanosensor NOUN s4655d8949g 13 39 or or CCONJ s4655d8949g 13 40 that that SCONJ s4655d8949g 13 41 only only ADV s4655d8949g 13 42 a a DET s4655d8949g 13 43 small small ADJ s4655d8949g 13 44 number number NOUN s4655d8949g 13 45 of of ADP s4655d8949g 13 46 cells cell NOUN s4655d8949g 13 47 are be AUX s4655d8949g 13 48 responsible responsible ADJ s4655d8949g 13 49 for for ADP s4655d8949g 13 50 mechanosensing mechanosense VERB s4655d8949g 13 51 in in ADP s4655d8949g 13 52 the the DET s4655d8949g 13 53 trabecular trabecular ADJ s4655d8949g 13 54 bone bone NOUN s4655d8949g 13 55 and and CCONJ s4655d8949g 13 56 marrow marrow NOUN s4655d8949g 13 57 compartment compartment NOUN s4655d8949g 13 58 . . PUNCT s4655d8949g 14 1 cilia cilia NUM s4655d8949g 14 2 expression expression NOUN s4655d8949g 14 3 in in ADP s4655d8949g 14 4 the the DET s4655d8949g 14 5 marrow marrow NOUN s4655d8949g 14 6 was be AUX s4655d8949g 14 7 higher high ADJ s4655d8949g 14 8 in in ADP s4655d8949g 14 9 static static ADJ s4655d8949g 14 10 cultured cultured ADJ s4655d8949g 14 11 explants explant NOUN s4655d8949g 14 12 , , PUNCT s4655d8949g 14 13 but but CCONJ s4655d8949g 14 14 decreased decrease VERB s4655d8949g 14 15 in in ADP s4655d8949g 14 16 response response NOUN s4655d8949g 14 17 to to ADP s4655d8949g 14 18 mechanical mechanical ADJ s4655d8949g 14 19 stimulation stimulation NOUN s4655d8949g 14 20 . . PUNCT s4655d8949g 15 1 this this PRON s4655d8949g 15 2 indicates indicate VERB s4655d8949g 15 3 that that SCONJ s4655d8949g 15 4 cilia cilia NOUN s4655d8949g 15 5 may may AUX s4655d8949g 15 6 have have VERB s4655d8949g 15 7 a a DET s4655d8949g 15 8 chemosensing chemosense VERB s4655d8949g 15 9 and and CCONJ s4655d8949g 15 10 mechanosensing mechanosensing NOUN s4655d8949g 15 11 role role NOUN s4655d8949g 15 12 in in ADP s4655d8949g 15 13 the the DET s4655d8949g 15 14 marrow marrow NOUN s4655d8949g 15 15 or or CCONJ s4655d8949g 15 16 are be AUX s4655d8949g 15 17 affected affect VERB s4655d8949g 15 18 by by ADP s4655d8949g 15 19 mechanosensing mechanosense VERB s4655d8949g 15 20 pathways pathway NOUN s4655d8949g 15 21 . . PUNCT s4655d8949g 16 1 in in ADP s4655d8949g 16 2 summary summary NOUN s4655d8949g 16 3 , , PUNCT s4655d8949g 16 4 the the DET s4655d8949g 16 5 mechanical mechanical ADJ s4655d8949g 16 6 environment environment NOUN s4655d8949g 16 7 in in ADP s4655d8949g 16 8 trabecular trabecular ADJ s4655d8949g 16 9 bone bone NOUN s4655d8949g 16 10 during during ADP s4655d8949g 16 11 lmms lmms PROPN s4655d8949g 16 12 was be AUX s4655d8949g 16 13 quantified quantify VERB s4655d8949g 16 14 . . PUNCT s4655d8949g 17 1 with with ADP s4655d8949g 17 2 the the DET s4655d8949g 17 3 results result NOUN s4655d8949g 17 4 from from ADP s4655d8949g 17 5 the the DET s4655d8949g 17 6 computational computational ADJ s4655d8949g 17 7 models model NOUN s4655d8949g 17 8 , , PUNCT s4655d8949g 17 9 trabecular trabecular ADJ s4655d8949g 17 10 bone bone NOUN s4655d8949g 17 11 explant explant NOUN s4655d8949g 17 12 biroeactor biroeactor NOUN s4655d8949g 17 13 culture culture NOUN s4655d8949g 17 14 with with ADP s4655d8949g 17 15 lmms lmms PROPN s4655d8949g 17 16 offers offer VERB s4655d8949g 17 17 the the DET s4655d8949g 17 18 ability ability NOUN s4655d8949g 17 19 to to PART s4655d8949g 17 20 study study VERB s4655d8949g 17 21 the the DET s4655d8949g 17 22 effects effect NOUN s4655d8949g 17 23 of of ADP s4655d8949g 17 24 an an DET s4655d8949g 17 25 alternative alternative ADJ s4655d8949g 17 26 mechanobiological mechanobiological ADJ s4655d8949g 17 27 signal signal NOUN s4655d8949g 17 28 on on ADP s4655d8949g 17 29 cellular cellular ADJ s4655d8949g 17 30 sensing sensing NOUN s4655d8949g 17 31 and and CCONJ s4655d8949g 17 32 biological biological ADJ s4655d8949g 17 33 function function NOUN s4655d8949g 17 34 . . PUNCT s4655d8949g 18 1 there there PRON s4655d8949g 18 2 is be VERB s4655d8949g 18 3 little little ADJ s4655d8949g 18 4 known know VERB s4655d8949g 18 5 about about ADP s4655d8949g 18 6 the the DET s4655d8949g 18 7 contribution contribution NOUN s4655d8949g 18 8 of of ADP s4655d8949g 18 9 bone bone NOUN s4655d8949g 18 10 marrow marrow NOUN s4655d8949g 18 11 cells cell NOUN s4655d8949g 18 12 to to ADP s4655d8949g 18 13 mechanotransduction mechanotransduction NOUN s4655d8949g 18 14 and and CCONJ s4655d8949g 18 15 the the DET s4655d8949g 18 16 subsequent subsequent ADJ s4655d8949g 18 17 signaling signaling NOUN s4655d8949g 18 18 that that PRON s4655d8949g 18 19 takes take VERB s4655d8949g 18 20 place place NOUN s4655d8949g 18 21 . . PUNCT s4655d8949g 19 1 this this DET s4655d8949g 19 2 explant explant NOUN s4655d8949g 19 3 bioreactor bioreactor NOUN s4655d8949g 19 4 culture culture NOUN s4655d8949g 19 5 system system NOUN s4655d8949g 19 6 and and CCONJ s4655d8949g 19 7 lmms lmms PROPN s4655d8949g 19 8 provides provide VERB s4655d8949g 19 9 a a DET s4655d8949g 19 10 tool tool NOUN s4655d8949g 19 11 to to PART s4655d8949g 19 12 study study VERB s4655d8949g 19 13 the the DET s4655d8949g 19 14 role role NOUN s4655d8949g 19 15 of of ADP s4655d8949g 19 16 marrow marrow NOUN s4655d8949g 19 17 cells cell NOUN s4655d8949g 19 18 in in ADP s4655d8949g 19 19 mechanotransduction mechanotransduction NOUN s4655d8949g 19 20 in in ADP s4655d8949g 19 21 order order NOUN s4655d8949g 19 22 to to PART s4655d8949g 19 23 make make VERB s4655d8949g 19 24 new new ADJ s4655d8949g 19 25 advances advance NOUN s4655d8949g 19 26 in in ADP s4655d8949g 19 27 bone bone NOUN s4655d8949g 19 28 mechanobiology mechanobiology NOUN s4655d8949g 19 29 . . PUNCT