id sid tid token lemma pos r781wd40p83 1 1 although although SCONJ r781wd40p83 1 2 a a DET r781wd40p83 1 3 comparatively comparatively ADV r781wd40p83 1 4 recent recent ADJ r781wd40p83 1 5 discovery discovery NOUN r781wd40p83 1 6 , , PUNCT r781wd40p83 1 7 induced induce VERB r781wd40p83 1 8 pluripotent pluripotent ADJ r781wd40p83 1 9 stem stem NOUN r781wd40p83 1 10 cells cell NOUN r781wd40p83 1 11 ( ( PUNCT r781wd40p83 1 12 ipscs ipscs NOUN r781wd40p83 1 13 ) ) PUNCT r781wd40p83 1 14 have have AUX r781wd40p83 1 15 enabled enable VERB r781wd40p83 1 16 astonishing astonishing ADJ r781wd40p83 1 17 advancements advancement NOUN r781wd40p83 1 18 in in ADP r781wd40p83 1 19 numerous numerous ADJ r781wd40p83 1 20 fields field NOUN r781wd40p83 1 21 of of ADP r781wd40p83 1 22 study study NOUN r781wd40p83 1 23 – – PUNCT r781wd40p83 1 24 particularly particularly ADV r781wd40p83 1 25 in in ADP r781wd40p83 1 26 the the DET r781wd40p83 1 27 areas area NOUN r781wd40p83 1 28 of of ADP r781wd40p83 1 29 regenerative regenerative ADJ r781wd40p83 1 30 medicine medicine NOUN r781wd40p83 1 31 and and CCONJ r781wd40p83 1 32 personalized personalized ADJ r781wd40p83 1 33 disease disease NOUN r781wd40p83 1 34 therapeutics therapeutic NOUN r781wd40p83 1 35 . . PUNCT r781wd40p83 2 1 by by ADP r781wd40p83 2 2 returning return VERB r781wd40p83 2 3 fully fully ADV r781wd40p83 2 4 - - PUNCT r781wd40p83 2 5 differentiated differentiate VERB r781wd40p83 2 6 adult adult NOUN r781wd40p83 2 7 cells cell NOUN r781wd40p83 2 8 to to ADP r781wd40p83 2 9 a a DET r781wd40p83 2 10 pluripotent pluripotent ADJ r781wd40p83 2 11 state state NOUN r781wd40p83 2 12 , , PUNCT r781wd40p83 2 13 ipscs ipsc NOUN r781wd40p83 2 14 capture capture VERB r781wd40p83 2 15 the the DET r781wd40p83 2 16 unique unique ADJ r781wd40p83 2 17 genetic genetic ADJ r781wd40p83 2 18 context context NOUN r781wd40p83 2 19 of of ADP r781wd40p83 2 20 their their PRON r781wd40p83 2 21 parental parental ADJ r781wd40p83 2 22 cell cell NOUN r781wd40p83 2 23 source source NOUN r781wd40p83 2 24 , , PUNCT r781wd40p83 2 25 and and CCONJ r781wd40p83 2 26 have have AUX r781wd40p83 2 27 allowed allow VERB r781wd40p83 2 28 researchers researcher NOUN r781wd40p83 2 29 to to PART r781wd40p83 2 30 model model VERB r781wd40p83 2 31 diseases disease NOUN r781wd40p83 2 32 affecting affect VERB r781wd40p83 2 33 hard hard ADJ r781wd40p83 2 34 - - PUNCT r781wd40p83 2 35 to to ADP r781wd40p83 2 36 - - PUNCT r781wd40p83 2 37 study study NOUN r781wd40p83 2 38 tissues tissue NOUN r781wd40p83 2 39 , , PUNCT r781wd40p83 2 40 to to PART r781wd40p83 2 41 study study VERB r781wd40p83 2 42 the the DET r781wd40p83 2 43 complex complex ADJ r781wd40p83 2 44 three three NUM r781wd40p83 2 45 - - PUNCT r781wd40p83 2 46 dimensional dimensional ADJ r781wd40p83 2 47 arrangement arrangement NOUN r781wd40p83 2 48 of of ADP r781wd40p83 2 49 cell cell NOUN r781wd40p83 2 50 types type NOUN r781wd40p83 2 51 in in ADP r781wd40p83 2 52 organ organ NOUN r781wd40p83 2 53 development development NOUN r781wd40p83 2 54 , , PUNCT r781wd40p83 2 55 and and CCONJ r781wd40p83 2 56 to to PART r781wd40p83 2 57 develop develop VERB r781wd40p83 2 58 stem stem NOUN r781wd40p83 2 59 cell cell NOUN r781wd40p83 2 60 - - PUNCT r781wd40p83 2 61 based base VERB r781wd40p83 2 62 therapies therapy NOUN r781wd40p83 2 63 for for ADP r781wd40p83 2 64 conditions condition NOUN r781wd40p83 2 65 ranging range VERB r781wd40p83 2 66 from from ADP r781wd40p83 2 67 retinal retinal ADJ r781wd40p83 2 68 degeneration degeneration NOUN r781wd40p83 2 69 to to ADP r781wd40p83 2 70 diabetes.stem diabetes.stem ADJ r781wd40p83 2 71 cell cell NOUN r781wd40p83 2 72 - - PUNCT r781wd40p83 2 73 based base VERB r781wd40p83 2 74 therapies therapy NOUN r781wd40p83 2 75 have have VERB r781wd40p83 2 76 a a DET r781wd40p83 2 77 long long ADJ r781wd40p83 2 78 history history NOUN r781wd40p83 2 79 in in ADP r781wd40p83 2 80 diseases disease NOUN r781wd40p83 2 81 of of ADP r781wd40p83 2 82 the the DET r781wd40p83 2 83 hematopoietic hematopoietic ADJ r781wd40p83 2 84 system system NOUN r781wd40p83 2 85 , , PUNCT r781wd40p83 2 86 where where SCONJ r781wd40p83 2 87 hematopoietic hematopoietic ADJ r781wd40p83 2 88 stem stem NOUN r781wd40p83 2 89 cell cell NOUN r781wd40p83 2 90 transplants transplant NOUN r781wd40p83 2 91 – – PUNCT r781wd40p83 2 92 most most ADV r781wd40p83 2 93 familiarly familiarly ADJ r781wd40p83 2 94 in in ADP r781wd40p83 2 95 the the DET r781wd40p83 2 96 form form NOUN r781wd40p83 2 97 of of ADP r781wd40p83 2 98 bone bone NOUN r781wd40p83 2 99 marrow marrow NOUN r781wd40p83 2 100 transplants transplant NOUN r781wd40p83 2 101 from from ADP r781wd40p83 2 102 healthy healthy ADJ r781wd40p83 2 103 donors donor NOUN r781wd40p83 2 104 – – PUNCT r781wd40p83 2 105 have have AUX r781wd40p83 2 106 been be AUX r781wd40p83 2 107 the the DET r781wd40p83 2 108 standard standard NOUN r781wd40p83 2 109 of of ADP r781wd40p83 2 110 care care NOUN r781wd40p83 2 111 for for ADP r781wd40p83 2 112 over over ADP r781wd40p83 2 113 forty forty NUM r781wd40p83 2 114 years year NOUN r781wd40p83 2 115 , , PUNCT r781wd40p83 2 116 often often ADV r781wd40p83 2 117 due due ADJ r781wd40p83 2 118 to to ADP r781wd40p83 2 119 a a DET r781wd40p83 2 120 lack lack NOUN r781wd40p83 2 121 of of ADP r781wd40p83 2 122 more more ADJ r781wd40p83 2 123 targeted target VERB r781wd40p83 2 124 therapeutic therapeutic ADJ r781wd40p83 2 125 options option NOUN r781wd40p83 2 126 because because SCONJ r781wd40p83 2 127 of of ADP r781wd40p83 2 128 an an DET r781wd40p83 2 129 incomplete incomplete ADJ r781wd40p83 2 130 understanding understanding NOUN r781wd40p83 2 131 of of ADP r781wd40p83 2 132 the the DET r781wd40p83 2 133 complex complex ADJ r781wd40p83 2 134 interactions interaction NOUN r781wd40p83 2 135 between between ADP r781wd40p83 2 136 genetic genetic ADJ r781wd40p83 2 137 aberrations aberration NOUN r781wd40p83 2 138 and and CCONJ r781wd40p83 2 139 the the DET r781wd40p83 2 140 development development NOUN r781wd40p83 2 141 and and CCONJ r781wd40p83 2 142 progression progression NOUN r781wd40p83 2 143 of of ADP r781wd40p83 2 144 disease disease NOUN r781wd40p83 2 145 . . PUNCT r781wd40p83 3 1 ipscs ipsc NOUN r781wd40p83 3 2 seemed seem VERB r781wd40p83 3 3 to to PART r781wd40p83 3 4 promise promise VERB r781wd40p83 3 5 an an DET r781wd40p83 3 6 exciting exciting ADJ r781wd40p83 3 7 alternative alternative ADJ r781wd40p83 3 8 option option NOUN r781wd40p83 3 9 for for ADP r781wd40p83 3 10 patients patient NOUN r781wd40p83 3 11 , , PUNCT r781wd40p83 3 12 circumventing circumvent VERB r781wd40p83 3 13 the the DET r781wd40p83 3 14 current current ADJ r781wd40p83 3 15 limitations limitation NOUN r781wd40p83 3 16 of of ADP r781wd40p83 3 17 donor donor NOUN r781wd40p83 3 18 availability availability NOUN r781wd40p83 3 19 and and CCONJ r781wd40p83 3 20 potentially potentially ADV r781wd40p83 3 21 lethal lethal ADJ r781wd40p83 3 22 immunological immunological ADJ r781wd40p83 3 23 side side NOUN r781wd40p83 3 24 effects effect NOUN r781wd40p83 3 25 , , PUNCT r781wd40p83 3 26 but but CCONJ r781wd40p83 3 27 thus thus ADV r781wd40p83 3 28 far far ADV r781wd40p83 3 29 the the DET r781wd40p83 3 30 production production NOUN r781wd40p83 3 31 of of ADP r781wd40p83 3 32 transplantable transplantable ADJ r781wd40p83 3 33 hscs hsc NOUN r781wd40p83 3 34 in in ADP r781wd40p83 3 35 vitro vitro X r781wd40p83 3 36 from from ADP r781wd40p83 3 37 any any DET r781wd40p83 3 38 human human ADJ r781wd40p83 3 39 pluripotent pluripotent ADJ r781wd40p83 3 40 stem stem NOUN r781wd40p83 3 41 cell cell NOUN r781wd40p83 3 42 source source NOUN r781wd40p83 3 43 has have AUX r781wd40p83 3 44 proven prove VERB r781wd40p83 3 45 elusive.this elusive.this NOUN r781wd40p83 3 46 dissertation dissertation NOUN r781wd40p83 3 47 represents represent VERB r781wd40p83 3 48 a a DET r781wd40p83 3 49 collection collection NOUN r781wd40p83 3 50 of of ADP r781wd40p83 3 51 studies study NOUN r781wd40p83 3 52 utilizing utilize VERB r781wd40p83 3 53 the the DET r781wd40p83 3 54 unique unique ADJ r781wd40p83 3 55 advantages advantage NOUN r781wd40p83 3 56 of of ADP r781wd40p83 3 57 ipscs ipsc NOUN r781wd40p83 3 58 to to PART r781wd40p83 3 59 produce produce VERB r781wd40p83 3 60 novel novel ADJ r781wd40p83 3 61 insights insight NOUN r781wd40p83 3 62 into into ADP r781wd40p83 3 63 both both CCONJ r781wd40p83 3 64 normal normal ADJ r781wd40p83 3 65 and and CCONJ r781wd40p83 3 66 disease disease NOUN r781wd40p83 3 67 - - PUNCT r781wd40p83 3 68 state state NOUN r781wd40p83 3 69 hematopoietic hematopoietic ADJ r781wd40p83 3 70 development development NOUN r781wd40p83 3 71 , , PUNCT r781wd40p83 3 72 as as ADV r781wd40p83 3 73 well well ADV r781wd40p83 3 74 as as ADP r781wd40p83 3 75 to to PART r781wd40p83 3 76 provide provide VERB r781wd40p83 3 77 resources resource NOUN r781wd40p83 3 78 for for ADP r781wd40p83 3 79 future future ADJ r781wd40p83 3 80 research research NOUN r781wd40p83 3 81 . . PUNCT r781wd40p83 4 1 in in ADP r781wd40p83 4 2 short short ADJ r781wd40p83 4 3 , , PUNCT r781wd40p83 4 4 these these DET r781wd40p83 4 5 studies study NOUN r781wd40p83 4 6 have have AUX r781wd40p83 4 7 identified identify VERB r781wd40p83 4 8 novel novel ADJ r781wd40p83 4 9 mirna mirna NOUN r781wd40p83 4 10 - - PUNCT r781wd40p83 4 11 modulated modulate VERB r781wd40p83 4 12 regulatory regulatory ADJ r781wd40p83 4 13 pathways pathway NOUN r781wd40p83 4 14 enriched enrich VERB r781wd40p83 4 15 in in ADP r781wd40p83 4 16 genes gene NOUN r781wd40p83 4 17 differentially differentially ADV r781wd40p83 4 18 - - PUNCT r781wd40p83 4 19 expressed express VERB r781wd40p83 4 20 between between ADP r781wd40p83 4 21 functional functional ADJ r781wd40p83 4 22 human human ADJ r781wd40p83 4 23 hscs hsc NOUN r781wd40p83 4 24 and and CCONJ r781wd40p83 4 25 their their PRON r781wd40p83 4 26 genetically genetically ADV r781wd40p83 4 27 - - PUNCT r781wd40p83 4 28 matched match VERB r781wd40p83 4 29 ipsc ipsc PROPN r781wd40p83 4 30 - - PUNCT r781wd40p83 4 31 derived derive VERB r781wd40p83 4 32 counterparts counterpart NOUN r781wd40p83 4 33 , , PUNCT r781wd40p83 4 34 providing provide VERB r781wd40p83 4 35 previously previously ADV r781wd40p83 4 36 unreported unreported ADJ r781wd40p83 4 37 insights insight NOUN r781wd40p83 4 38 into into ADP r781wd40p83 4 39 recapitulating recapitulate VERB r781wd40p83 4 40 normal normal ADJ r781wd40p83 4 41 hematopoietic hematopoietic ADJ r781wd40p83 4 42 development development NOUN r781wd40p83 4 43 in in ADP r781wd40p83 4 44 vitro vitro X r781wd40p83 4 45 . . PUNCT r781wd40p83 5 1 in in ADP r781wd40p83 5 2 parallel parallel NOUN r781wd40p83 5 3 , , PUNCT r781wd40p83 5 4 these these DET r781wd40p83 5 5 studies study NOUN r781wd40p83 5 6 have have AUX r781wd40p83 5 7 also also ADV r781wd40p83 5 8 demonstrated demonstrate VERB r781wd40p83 5 9 both both CCONJ r781wd40p83 5 10 the the DET r781wd40p83 5 11 therapeutic therapeutic ADJ r781wd40p83 5 12 potential potential NOUN r781wd40p83 5 13 of of ADP r781wd40p83 5 14 ipscs ipsc NOUN r781wd40p83 5 15 for for ADP r781wd40p83 5 16 patients patient NOUN r781wd40p83 5 17 with with ADP r781wd40p83 5 18 genetically genetically ADV r781wd40p83 5 19 - - PUNCT r781wd40p83 5 20 driven drive VERB r781wd40p83 5 21 hematological hematological ADJ r781wd40p83 5 22 malignancies malignancy NOUN r781wd40p83 5 23 by by ADP r781wd40p83 5 24 producing produce VERB r781wd40p83 5 25 karyotypically karyotypically PROPN r781wd40p83 5 26 normal normal ADJ r781wd40p83 5 27 ipsc ipsc ADJ r781wd40p83 5 28 lines line NOUN r781wd40p83 5 29 with with ADP r781wd40p83 5 30 restored restore VERB r781wd40p83 5 31 differentiation differentiation NOUN r781wd40p83 5 32 potential potential NOUN r781wd40p83 5 33 from from ADP r781wd40p83 5 34 a a DET r781wd40p83 5 35 patient patient ADJ r781wd40p83 5 36 sample sample NOUN r781wd40p83 5 37 of of ADP r781wd40p83 5 38 acute acute ADJ r781wd40p83 5 39 myeloid myeloid PROPN r781wd40p83 5 40 leukemia leukemia NOUN r781wd40p83 5 41 ( ( PUNCT r781wd40p83 5 42 aml aml PROPN r781wd40p83 5 43 ) ) PUNCT r781wd40p83 5 44 , , PUNCT r781wd40p83 5 45 and and CCONJ r781wd40p83 5 46 the the DET r781wd40p83 5 47 utility utility NOUN r781wd40p83 5 48 of of ADP r781wd40p83 5 49 ipscs ipscs NOUN r781wd40p83 5 50 as as ADP r781wd40p83 5 51 a a DET r781wd40p83 5 52 disease disease NOUN r781wd40p83 5 53 modeling model VERB r781wd40p83 5 54 resource resource NOUN r781wd40p83 5 55 by by ADP r781wd40p83 5 56 producing produce VERB r781wd40p83 5 57 the the DET r781wd40p83 5 58 first first ADJ r781wd40p83 5 59 report report NOUN r781wd40p83 5 60 of of ADP r781wd40p83 5 61 a a DET r781wd40p83 5 62 stable stable ADJ r781wd40p83 5 63 ipsc ipsc ADJ r781wd40p83 5 64 line line NOUN r781wd40p83 5 65 from from ADP r781wd40p83 5 66 the the DET r781wd40p83 5 67 leukemic leukemic ADJ r781wd40p83 5 68 hl-60 hl-60 X r781wd40p83 5 69 cell cell NOUN r781wd40p83 5 70 line line NOUN r781wd40p83 5 71 . . PUNCT r781wd40p83 6 1 these these DET r781wd40p83 6 2 findings finding NOUN r781wd40p83 6 3 lay lie VERB r781wd40p83 6 4 the the DET r781wd40p83 6 5 foundations foundation NOUN r781wd40p83 6 6 for for ADP r781wd40p83 6 7 future future ADJ r781wd40p83 6 8 studies study NOUN r781wd40p83 6 9 to to PART r781wd40p83 6 10 significantly significantly ADV r781wd40p83 6 11 advance advance VERB r781wd40p83 6 12 our our PRON r781wd40p83 6 13 understanding understanding NOUN r781wd40p83 6 14 of of ADP r781wd40p83 6 15 hematopoietic hematopoietic ADJ r781wd40p83 6 16 development development NOUN r781wd40p83 6 17 and and CCONJ r781wd40p83 6 18 , , PUNCT r781wd40p83 6 19 in in ADP r781wd40p83 6 20 turn turn NOUN r781wd40p83 6 21 , , PUNCT r781wd40p83 6 22 aid aid NOUN r781wd40p83 6 23 in in ADP r781wd40p83 6 24 the the DET r781wd40p83 6 25 production production NOUN r781wd40p83 6 26 of of ADP r781wd40p83 6 27 novel novel ADJ r781wd40p83 6 28 therapeutic therapeutic ADJ r781wd40p83 6 29 options option NOUN r781wd40p83 6 30 for for ADP r781wd40p83 6 31 patients patient NOUN r781wd40p83 6 32 . . PUNCT