id	sid	tid	token	lemma	pos
r207tm7328m	1	1	niemann	niemann	PROPN
r207tm7328m	1	2	-	-	PUNCT
r207tm7328m	1	3	pick	pick	NOUN
r207tm7328m	1	4	type	type	NOUN
r207tm7328m	1	5	c	c	NOUN
r207tm7328m	1	6	is	be	AUX
r207tm7328m	1	7	a	a	DET
r207tm7328m	1	8	rare	rare	ADJ
r207tm7328m	1	9	and	and	CCONJ
r207tm7328m	1	10	fatal	fatal	ADJ
r207tm7328m	1	11	disease	disease	NOUN
r207tm7328m	1	12	that	that	PRON
r207tm7328m	1	13	results	result	VERB
r207tm7328m	1	14	in	in	ADP
r207tm7328m	1	15	the	the	DET
r207tm7328m	1	16	accumulation	accumulation	NOUN
r207tm7328m	1	17	of	of	ADP
r207tm7328m	1	18	cholesterol	cholesterol	NOUN
r207tm7328m	1	19	within	within	ADP
r207tm7328m	1	20	lysosomes	lysosome	NOUN
r207tm7328m	1	21	.	.	PUNCT
r207tm7328m	2	1	a	a	DET
r207tm7328m	2	2	monogenic	monogenic	ADJ
r207tm7328m	2	3	disorder	disorder	NOUN
r207tm7328m	2	4	that	that	PRON
r207tm7328m	2	5	shows	show	VERB
r207tm7328m	2	6	recessive	recessive	ADJ
r207tm7328m	2	7	inheritance	inheritance	NOUN
r207tm7328m	2	8	,	,	PUNCT
r207tm7328m	2	9	there	there	PRON
r207tm7328m	2	10	is	be	VERB
r207tm7328m	2	11	currently	currently	ADV
r207tm7328m	2	12	no	no	DET
r207tm7328m	2	13	fda	fda	PROPN
r207tm7328m	2	14	approved	approve	VERB
r207tm7328m	2	15	treatment	treatment	NOUN
r207tm7328m	2	16	for	for	ADP
r207tm7328m	2	17	this	this	DET
r207tm7328m	2	18	terrible	terrible	ADJ
r207tm7328m	2	19	disease	disease	NOUN
r207tm7328m	2	20	.	.	PUNCT
r207tm7328m	3	1	research	research	NOUN
r207tm7328m	3	2	efforts	effort	NOUN
r207tm7328m	3	3	have	have	AUX
r207tm7328m	3	4	implicated	implicate	VERB
r207tm7328m	3	5	the	the	DET
r207tm7328m	3	6	role	role	NOUN
r207tm7328m	3	7	of	of	ADP
r207tm7328m	3	8	the	the	DET
r207tm7328m	3	9	npc1	npc1	ADJ
r207tm7328m	3	10	and	and	CCONJ
r207tm7328m	3	11	npc2	npc2	ADJ
r207tm7328m	3	12	proteins	protein	NOUN
r207tm7328m	3	13	in	in	ADP
r207tm7328m	3	14	cholesterol	cholesterol	NOUN
r207tm7328m	3	15	trafficking	trafficking	NOUN
r207tm7328m	3	16	within	within	ADP
r207tm7328m	3	17	lysosomes	lysosome	NOUN
r207tm7328m	3	18	.	.	PUNCT
r207tm7328m	4	1	histone	histone	NOUN
r207tm7328m	4	2	deacetylase	deacetylase	NOUN
r207tm7328m	4	3	inhibitors	inhibitor	NOUN
r207tm7328m	4	4	,	,	PUNCT
r207tm7328m	4	5	such	such	ADJ
r207tm7328m	4	6	as	as	ADP
r207tm7328m	4	7	trichostatin	trichostatin	PROPN
r207tm7328m	4	8	a	a	PRON
r207tm7328m	4	9	and	and	CCONJ
r207tm7328m	4	10	vorinostat	vorinostat	NOUN
r207tm7328m	4	11	,	,	PUNCT
r207tm7328m	4	12	have	have	AUX
r207tm7328m	4	13	recently	recently	ADV
r207tm7328m	4	14	been	be	AUX
r207tm7328m	4	15	shown	show	VERB
r207tm7328m	4	16	to	to	PART
r207tm7328m	4	17	restore	restore	VERB
r207tm7328m	4	18	cholesterol	cholesterol	NOUN
r207tm7328m	4	19	homeostasis	homeostasis	NOUN
r207tm7328m	4	20	in	in	ADP
r207tm7328m	4	21	niemann	niemann	PROPN
r207tm7328m	4	22	-	-	PUNCT
r207tm7328m	4	23	pick	pick	NOUN
r207tm7328m	4	24	type	type	NOUN
r207tm7328m	4	25	c	c	NOUN
r207tm7328m	4	26	mutant	mutant	ADJ
r207tm7328m	4	27	cell	cell	NOUN
r207tm7328m	4	28	lines	line	NOUN
r207tm7328m	4	29	.	.	PUNCT
r207tm7328m	5	1	this	this	PRON
r207tm7328m	5	2	has	have	AUX
r207tm7328m	5	3	been	be	AUX
r207tm7328m	5	4	attributed	attribute	VERB
r207tm7328m	5	5	to	to	ADP
r207tm7328m	5	6	their	their	PRON
r207tm7328m	5	7	ability	ability	NOUN
r207tm7328m	5	8	to	to	PART
r207tm7328m	5	9	upregulate	upregulate	VERB
r207tm7328m	5	10	the	the	DET
r207tm7328m	5	11	expression	expression	NOUN
r207tm7328m	5	12	of	of	ADP
r207tm7328m	5	13	the	the	DET
r207tm7328m	5	14	npc1	npc1	PROPN
r207tm7328m	5	15	protein.in	protein.in	X
r207tm7328m	5	16	1997	1997	NUM
r207tm7328m	5	17	,	,	PUNCT
r207tm7328m	5	18	type	type	NOUN
r207tm7328m	5	19	i	i	PRON
r207tm7328m	5	20	polyketide	polyketide	NOUN
r207tm7328m	5	21	natural	natural	ADJ
r207tm7328m	5	22	product	product	NOUN
r207tm7328m	5	23	gex1a	gex1a	PROPN
r207tm7328m	5	24	was	be	AUX
r207tm7328m	5	25	shown	show	VERB
r207tm7328m	5	26	to	to	PART
r207tm7328m	5	27	regulate	regulate	VERB
r207tm7328m	5	28	cholesterol	cholesterol	NOUN
r207tm7328m	5	29	in	in	ADP
r207tm7328m	5	30	a	a	DET
r207tm7328m	5	31	manner	manner	NOUN
r207tm7328m	5	32	comparable	comparable	ADJ
r207tm7328m	5	33	to	to	ADP
r207tm7328m	5	34	that	that	PRON
r207tm7328m	5	35	of	of	ADP
r207tm7328m	5	36	trichostatin	trichostatin	PROPN
r207tm7328m	5	37	a.	a.	PROPN
r207tm7328m	5	38	unlike	unlike	ADP
r207tm7328m	5	39	trichostatin	trichostatin	PROPN
r207tm7328m	5	40	a	a	PRON
r207tm7328m	5	41	,	,	PUNCT
r207tm7328m	5	42	gex1a	gex1a	PROPN
r207tm7328m	5	43	does	do	AUX
r207tm7328m	5	44	not	not	PART
r207tm7328m	5	45	impact	impact	VERB
r207tm7328m	5	46	histone	histone	NOUN
r207tm7328m	5	47	acetylation	acetylation	NOUN
r207tm7328m	5	48	.	.	PUNCT
r207tm7328m	6	1	rather	rather	ADV
r207tm7328m	6	2	,	,	PUNCT
r207tm7328m	6	3	gex1a	gex1a	PROPN
r207tm7328m	6	4	modulates	modulate	NOUN
r207tm7328m	6	5	alternative	alternative	ADJ
r207tm7328m	6	6	pre	pre	ADJ
r207tm7328m	6	7	-	-	ADJ
r207tm7328m	6	8	mrna	mrna	ADJ
r207tm7328m	6	9	splicing	splicing	NOUN
r207tm7328m	6	10	by	by	ADP
r207tm7328m	6	11	targeting	target	VERB
r207tm7328m	6	12	the	the	DET
r207tm7328m	6	13	sf3b	sf3b	NOUN
r207tm7328m	6	14	subunit	subunit	NOUN
r207tm7328m	6	15	of	of	ADP
r207tm7328m	6	16	the	the	DET
r207tm7328m	6	17	spliceosome	spliceosome	PROPN
r207tm7328m	6	18	.	.	PUNCT
r207tm7328m	7	1	our	our	PRON
r207tm7328m	7	2	laboratory	laboratory	NOUN
r207tm7328m	7	3	determined	determine	VERB
r207tm7328m	7	4	that	that	SCONJ
r207tm7328m	7	5	the	the	DET
r207tm7328m	7	6	novel	novel	ADJ
r207tm7328m	7	7	cholesterol	cholesterol	NOUN
r207tm7328m	7	8	activity	activity	NOUN
r207tm7328m	7	9	of	of	ADP
r207tm7328m	7	10	gex1a	gex1a	PROPN
r207tm7328m	7	11	merited	merit	VERB
r207tm7328m	7	12	further	further	ADJ
r207tm7328m	7	13	investigation	investigation	NOUN
r207tm7328m	7	14	within	within	ADP
r207tm7328m	7	15	the	the	DET
r207tm7328m	7	16	context	context	NOUN
r207tm7328m	7	17	of	of	ADP
r207tm7328m	7	18	niemann	niemann	PROPN
r207tm7328m	7	19	-	-	PUNCT
r207tm7328m	7	20	pick	pick	NOUN
r207tm7328m	7	21	type	type	NOUN
r207tm7328m	7	22	c.through	c.through	NOUN
r207tm7328m	7	23	isolation	isolation	NOUN
r207tm7328m	7	24	of	of	ADP
r207tm7328m	7	25	natural	natural	ADJ
r207tm7328m	7	26	gex1a	gex1a	PROPN
r207tm7328m	7	27	from	from	ADP
r207tm7328m	7	28	its	its	PRON
r207tm7328m	7	29	producing	produce	VERB
r207tm7328m	7	30	organism	organism	NOUN
r207tm7328m	7	31	,	,	PUNCT
r207tm7328m	7	32	our	our	PRON
r207tm7328m	7	33	laboratory	laboratory	NOUN
r207tm7328m	7	34	has	have	AUX
r207tm7328m	7	35	demonstrated	demonstrate	VERB
r207tm7328m	7	36	that	that	SCONJ
r207tm7328m	7	37	gex1a	gex1a	PROPN
r207tm7328m	7	38	represents	represent	VERB
r207tm7328m	7	39	a	a	DET
r207tm7328m	7	40	novel	novel	ADJ
r207tm7328m	7	41	therapeutic	therapeutic	ADJ
r207tm7328m	7	42	candidate	candidate	NOUN
r207tm7328m	7	43	for	for	ADP
r207tm7328m	7	44	niemann	niemann	PROPN
r207tm7328m	7	45	-	-	PUNCT
r207tm7328m	7	46	pick	pick	NOUN
r207tm7328m	7	47	type	type	NOUN
r207tm7328m	7	48	c.	c.	PROPN
r207tm7328m	7	49	specifically	specifically	ADV
r207tm7328m	7	50	,	,	PUNCT
r207tm7328m	7	51	gex1a	gex1a	PROPN
r207tm7328m	7	52	restores	restore	VERB
r207tm7328m	7	53	cholesterol	cholesterol	NOUN
r207tm7328m	7	54	homeostasis	homeostasis	NOUN
r207tm7328m	7	55	in	in	ADP
r207tm7328m	7	56	npc1	npc1	PROPN
r207tm7328m	7	57	mutant	mutant	ADJ
r207tm7328m	7	58	cell	cell	NOUN
r207tm7328m	7	59	lines	line	NOUN
r207tm7328m	7	60	and	and	CCONJ
r207tm7328m	7	61	cells	cell	NOUN
r207tm7328m	7	62	induced	induce	VERB
r207tm7328m	7	63	with	with	ADP
r207tm7328m	7	64	the	the	DET
r207tm7328m	7	65	disease	disease	NOUN
r207tm7328m	7	66	associated	associate	VERB
r207tm7328m	7	67	phenotype	phenotype	NOUN
r207tm7328m	7	68	.	.	PUNCT
r207tm7328m	8	1	to	to	PART
r207tm7328m	8	2	expand	expand	VERB
r207tm7328m	8	3	on	on	ADP
r207tm7328m	8	4	these	these	DET
r207tm7328m	8	5	initial	initial	ADJ
r207tm7328m	8	6	studies	study	NOUN
r207tm7328m	8	7	,	,	PUNCT
r207tm7328m	8	8	our	our	PRON
r207tm7328m	8	9	laboratory	laboratory	NOUN
r207tm7328m	8	10	targeted	target	VERB
r207tm7328m	8	11	novel	novel	NOUN
r207tm7328m	8	12	structural	structural	ADJ
r207tm7328m	8	13	analogues	analogue	NOUN
r207tm7328m	8	14	of	of	ADP
r207tm7328m	8	15	gex1a	gex1a	PROPN
r207tm7328m	8	16	through	through	ADP
r207tm7328m	8	17	a	a	DET
r207tm7328m	8	18	synthetic	synthetic	ADJ
r207tm7328m	8	19	and	and	CCONJ
r207tm7328m	8	20	semi	semi	ADJ
r207tm7328m	8	21	-	-	ADJ
r207tm7328m	8	22	synthetic	synthetic	ADJ
r207tm7328m	8	23	approach	approach	NOUN
r207tm7328m	8	24	,	,	PUNCT
r207tm7328m	8	25	in	in	ADP
r207tm7328m	8	26	an	an	DET
r207tm7328m	8	27	effort	effort	NOUN
r207tm7328m	8	28	to	to	PART
r207tm7328m	8	29	discern	discern	VERB
r207tm7328m	8	30	the	the	DET
r207tm7328m	8	31	pharmacophore	pharmacophore	NOUN
r207tm7328m	8	32	responsible	responsible	ADJ
r207tm7328m	8	33	for	for	ADP
r207tm7328m	8	34	this	this	DET
r207tm7328m	8	35	unique	unique	ADJ
r207tm7328m	8	36	cholesterol	cholesterol	NOUN
r207tm7328m	8	37	regulatory	regulatory	ADJ
r207tm7328m	8	38	ability.a	ability.a	PROPN
r207tm7328m	8	39	synthetic	synthetic	ADJ
r207tm7328m	8	40	strategy	strategy	NOUN
r207tm7328m	8	41	was	be	AUX
r207tm7328m	8	42	devised	devise	VERB
r207tm7328m	8	43	that	that	PRON
r207tm7328m	8	44	produced	produce	VERB
r207tm7328m	8	45	two	two	NUM
r207tm7328m	8	46	novel	novel	ADJ
r207tm7328m	8	47	analogues	analogue	NOUN
r207tm7328m	8	48	,	,	PUNCT
r207tm7328m	8	49	as	as	ADV
r207tm7328m	8	50	well	well	ADV
r207tm7328m	8	51	as	as	ADP
r207tm7328m	8	52	an	an	DET
r207tm7328m	8	53	additional	additional	ADJ
r207tm7328m	8	54	compound	compound	NOUN
r207tm7328m	8	55	that	that	PRON
r207tm7328m	8	56	had	have	AUX
r207tm7328m	8	57	previously	previously	ADV
r207tm7328m	8	58	been	be	AUX
r207tm7328m	8	59	disclosed	disclose	VERB
r207tm7328m	8	60	in	in	ADP
r207tm7328m	8	61	the	the	DET
r207tm7328m	8	62	literature	literature	NOUN
r207tm7328m	8	63	.	.	PUNCT
r207tm7328m	9	1	semi	semi	ADJ
r207tm7328m	9	2	-	-	NOUN
r207tm7328m	9	3	synthesis	synthesis	NOUN
r207tm7328m	9	4	of	of	ADP
r207tm7328m	9	5	the	the	DET
r207tm7328m	9	6	natural	natural	ADJ
r207tm7328m	9	7	product	product	NOUN
r207tm7328m	9	8	also	also	ADV
r207tm7328m	9	9	generated	generate	VERB
r207tm7328m	9	10	a	a	DET
r207tm7328m	9	11	number	number	NOUN
r207tm7328m	9	12	of	of	ADP
r207tm7328m	9	13	analogues	analogue	NOUN
r207tm7328m	9	14	,	,	PUNCT
r207tm7328m	9	15	with	with	ADP
r207tm7328m	9	16	a	a	DET
r207tm7328m	9	17	particular	particular	ADJ
r207tm7328m	9	18	focus	focus	NOUN
r207tm7328m	9	19	on	on	ADP
r207tm7328m	9	20	the	the	DET
r207tm7328m	9	21	manipulation	manipulation	NOUN
r207tm7328m	9	22	of	of	ADP
r207tm7328m	9	23	the	the	DET
r207tm7328m	9	24	c18	c18	PROPN
r207tm7328m	9	25	hydroxyl	hydroxyl	PROPN
r207tm7328m	9	26	moiety	moiety	PROPN
r207tm7328m	9	27	of	of	ADP
r207tm7328m	9	28	gex1a	gex1a	PROPN
r207tm7328m	9	29	.	.	PUNCT
r207tm7328m	10	1	the	the	DET
r207tm7328m	10	2	efficacy	efficacy	NOUN
r207tm7328m	10	3	of	of	ADP
r207tm7328m	10	4	these	these	DET
r207tm7328m	10	5	compounds	compound	NOUN
r207tm7328m	10	6	with	with	ADP
r207tm7328m	10	7	respect	respect	NOUN
r207tm7328m	10	8	to	to	ADP
r207tm7328m	10	9	restoring	restore	VERB
r207tm7328m	10	10	cholesterol	cholesterol	NOUN
r207tm7328m	10	11	homeostasis	homeostasis	NOUN
r207tm7328m	10	12	in	in	ADP
r207tm7328m	10	13	niemann	niemann	PROPN
r207tm7328m	10	14	-	-	PUNCT
r207tm7328m	10	15	pick	pick	NOUN
r207tm7328m	10	16	type	type	NOUN
r207tm7328m	10	17	c	c	NOUN
r207tm7328m	10	18	mutant	mutant	ADJ
r207tm7328m	10	19	cell	cell	NOUN
r207tm7328m	10	20	lines	line	NOUN
r207tm7328m	10	21	was	be	AUX
r207tm7328m	10	22	examined	examine	VERB
r207tm7328m	10	23	,	,	PUNCT
r207tm7328m	10	24	and	and	CCONJ
r207tm7328m	10	25	the	the	DET
r207tm7328m	10	26	data	datum	NOUN
r207tm7328m	10	27	has	have	AUX
r207tm7328m	10	28	provided	provide	VERB
r207tm7328m	10	29	valuable	valuable	ADJ
r207tm7328m	10	30	insights	insight	NOUN
r207tm7328m	10	31	regarding	regard	VERB
r207tm7328m	10	32	the	the	DET
r207tm7328m	10	33	structure	structure	NOUN
r207tm7328m	10	34	and	and	CCONJ
r207tm7328m	10	35	activity	activity	NOUN
r207tm7328m	10	36	of	of	ADP
r207tm7328m	10	37	gex1a.ultimately	gex1a.ultimately	ADV
r207tm7328m	10	38	,	,	PUNCT
r207tm7328m	10	39	the	the	DET
r207tm7328m	10	40	results	result	NOUN
r207tm7328m	10	41	of	of	ADP
r207tm7328m	10	42	these	these	DET
r207tm7328m	10	43	studies	study	NOUN
r207tm7328m	10	44	have	have	AUX
r207tm7328m	10	45	demonstrated	demonstrate	VERB
r207tm7328m	10	46	that	that	SCONJ
r207tm7328m	10	47	gex1a	gex1a	PROPN
r207tm7328m	10	48	represents	represent	VERB
r207tm7328m	10	49	a	a	DET
r207tm7328m	10	50	therapeutic	therapeutic	ADJ
r207tm7328m	10	51	candidate	candidate	NOUN
r207tm7328m	10	52	for	for	ADP
r207tm7328m	10	53	the	the	DET
r207tm7328m	10	54	treatment	treatment	NOUN
r207tm7328m	10	55	of	of	ADP
r207tm7328m	10	56	niemann	niemann	PROPN
r207tm7328m	10	57	-	-	PUNCT
r207tm7328m	10	58	pick	pick	NOUN
r207tm7328m	10	59	type	type	NOUN
r207tm7328m	10	60	c	c	NOUN
r207tm7328m	10	61	disease	disease	NOUN
r207tm7328m	10	62	.	.	PUNCT
r207tm7328m	11	1	this	this	PRON
r207tm7328m	11	2	advocates	advocate	VERB
r207tm7328m	11	3	that	that	SCONJ
r207tm7328m	11	4	other	other	ADJ
r207tm7328m	11	5	natural	natural	ADJ
r207tm7328m	11	6	products	product	NOUN
r207tm7328m	11	7	that	that	PRON
r207tm7328m	11	8	modulate	modulate	VERB
r207tm7328m	11	9	alternative	alternative	ADJ
r207tm7328m	11	10	splicing	splicing	NOUN
r207tm7328m	11	11	warrant	warrant	NOUN
r207tm7328m	11	12	further	further	ADJ
r207tm7328m	11	13	investigation	investigation	NOUN
r207tm7328m	11	14	as	as	ADP
r207tm7328m	11	15	targets	target	NOUN
r207tm7328m	11	16	for	for	ADP
r207tm7328m	11	17	the	the	DET
r207tm7328m	11	18	treatment	treatment	NOUN
r207tm7328m	11	19	of	of	ADP
r207tm7328m	11	20	niemann	niemann	PROPN
r207tm7328m	11	21	-	-	PUNCT
r207tm7328m	11	22	pick	pick	NOUN
r207tm7328m	11	23	type	type	NOUN
r207tm7328m	11	24	c.	c.	PROPN