id	sid	tid	token	lemma	pos
r207tm7310j	1	1	multiple	multiple	ADJ
r207tm7310j	1	2	myeloma	myeloma	NOUN
r207tm7310j	1	3	(	(	PUNCT
r207tm7310j	1	4	mm	mm	PROPN
r207tm7310j	1	5	)	)	PUNCT
r207tm7310j	1	6	is	be	AUX
r207tm7310j	1	7	a	a	DET
r207tm7310j	1	8	hematological	hematological	ADJ
r207tm7310j	1	9	malignancy	malignancy	NOUN
r207tm7310j	1	10	which	which	PRON
r207tm7310j	1	11	results	result	VERB
r207tm7310j	1	12	from	from	ADP
r207tm7310j	1	13	the	the	DET
r207tm7310j	1	14	uncontrolled	uncontrolled	ADJ
r207tm7310j	1	15	clonal	clonal	ADJ
r207tm7310j	1	16	expansion	expansion	NOUN
r207tm7310j	1	17	of	of	ADP
r207tm7310j	1	18	plasma	plasma	NOUN
r207tm7310j	1	19	cells	cell	NOUN
r207tm7310j	1	20	within	within	ADP
r207tm7310j	1	21	the	the	DET
r207tm7310j	1	22	body	body	NOUN
r207tm7310j	1	23	.	.	PUNCT
r207tm7310j	2	1	despite	despite	SCONJ
r207tm7310j	2	2	recent	recent	ADJ
r207tm7310j	2	3	medical	medical	ADJ
r207tm7310j	2	4	advances	advance	NOUN
r207tm7310j	2	5	,	,	PUNCT
r207tm7310j	2	6	this	this	DET
r207tm7310j	2	7	disease	disease	NOUN
r207tm7310j	2	8	remains	remain	VERB
r207tm7310j	2	9	largely	largely	ADV
r207tm7310j	2	10	incurable	incurable	ADJ
r207tm7310j	2	11	,	,	PUNCT
r207tm7310j	2	12	with	with	ADP
r207tm7310j	2	13	a	a	DET
r207tm7310j	2	14	median	median	ADJ
r207tm7310j	2	15	survival	survival	NOUN
r207tm7310j	2	16	of	of	ADP
r207tm7310j	2	17	~7	~7	NUM
r207tm7310j	2	18	years	year	NOUN
r207tm7310j	2	19	,	,	PUNCT
r207tm7310j	2	20	owing	owe	VERB
r207tm7310j	2	21	to	to	ADP
r207tm7310j	2	22	the	the	DET
r207tm7310j	2	23	development	development	NOUN
r207tm7310j	2	24	of	of	ADP
r207tm7310j	2	25	drug	drug	NOUN
r207tm7310j	2	26	resistance	resistance	NOUN
r207tm7310j	2	27	.	.	PUNCT
r207tm7310j	3	1	this	this	DET
r207tm7310j	3	2	dissertation	dissertation	NOUN
r207tm7310j	3	3	will	will	AUX
r207tm7310j	3	4	explore	explore	VERB
r207tm7310j	3	5	new	new	ADJ
r207tm7310j	3	6	advances	advance	NOUN
r207tm7310j	3	7	in	in	ADP
r207tm7310j	3	8	nanotechnology	nanotechnology	NOUN
r207tm7310j	3	9	that	that	PRON
r207tm7310j	3	10	will	will	AUX
r207tm7310j	3	11	combine	combine	VERB
r207tm7310j	3	12	the	the	DET
r207tm7310j	3	13	cytotoxic	cytotoxic	ADJ
r207tm7310j	3	14	effects	effect	NOUN
r207tm7310j	3	15	of	of	ADP
r207tm7310j	3	16	small	small	ADJ
r207tm7310j	3	17	molecule	molecule	NOUN
r207tm7310j	3	18	chemotherapeutics	chemotherapeutic	NOUN
r207tm7310j	3	19	with	with	ADP
r207tm7310j	3	20	the	the	DET
r207tm7310j	3	21	tumor	tumor	NOUN
r207tm7310j	3	22	targeting	targeting	NOUN
r207tm7310j	3	23	capabilities	capability	NOUN
r207tm7310j	3	24	of	of	ADP
r207tm7310j	3	25	nanoparticles	nanoparticle	NOUN
r207tm7310j	3	26	to	to	PART
r207tm7310j	3	27	create	create	VERB
r207tm7310j	3	28	novel	novel	ADJ
r207tm7310j	3	29	nanoparticle	nanoparticle	NOUN
r207tm7310j	3	30	formulations	formulation	NOUN
r207tm7310j	3	31	that	that	PRON
r207tm7310j	3	32	exhibit	exhibit	VERB
r207tm7310j	3	33	enhanced	enhance	VERB
r207tm7310j	3	34	therapeutic	therapeutic	ADJ
r207tm7310j	3	35	indices	index	NOUN
r207tm7310j	3	36	in	in	ADP
r207tm7310j	3	37	the	the	DET
r207tm7310j	3	38	treatment	treatment	NOUN
r207tm7310j	3	39	of	of	ADP
r207tm7310j	3	40	mm	mm	PROPN
r207tm7310j	3	41	.	.	PUNCT
r207tm7310j	4	1	first	first	ADV
r207tm7310j	4	2	,	,	PUNCT
r207tm7310j	4	3	doxorubicin	doxorubicin	PROPN
r207tm7310j	4	4	was	be	AUX
r207tm7310j	4	5	surfaced	surface	VERB
r207tm7310j	4	6	conjugated	conjugate	VERB
r207tm7310j	4	7	onto	onto	ADP
r207tm7310j	4	8	micellar	micellar	ADJ
r207tm7310j	4	9	nanoparticles	nanoparticle	NOUN
r207tm7310j	4	10	via	via	ADP
r207tm7310j	4	11	an	an	DET
r207tm7310j	4	12	acid	acid	PROPN
r207tm7310j	4	13	labile	labile	ADJ
r207tm7310j	4	14	hydrazone	hydrazone	NOUN
r207tm7310j	4	15	bond	bond	NOUN
r207tm7310j	4	16	to	to	PART
r207tm7310j	4	17	increase	increase	VERB
r207tm7310j	4	18	the	the	DET
r207tm7310j	4	19	drug	drug	NOUN
r207tm7310j	4	20	accumulation	accumulation	NOUN
r207tm7310j	4	21	at	at	ADP
r207tm7310j	4	22	the	the	DET
r207tm7310j	4	23	tumor	tumor	NOUN
r207tm7310j	4	24	.	.	PUNCT
r207tm7310j	5	1	the	the	DET
r207tm7310j	5	2	cell	cell	NOUN
r207tm7310j	5	3	surface	surface	NOUN
r207tm7310j	5	4	receptor	receptor	NOUN
r207tm7310j	5	5	very	very	ADV
r207tm7310j	5	6	late	late	ADV
r207tm7310j	5	7	antigen-4	antigen-4	PROPN
r207tm7310j	5	8	(	(	PUNCT
r207tm7310j	5	9	vla-4	vla-4	NOUN
r207tm7310j	5	10	;	;	PUNCT
r207tm7310j	5	11	&	&	CCONJ
r207tm7310j	5	12	#	#	SYM
r207tm7310j	5	13	945;4β1	945;4β1	NUM
r207tm7310j	5	14	)	)	PUNCT
r207tm7310j	5	15	is	be	AUX
r207tm7310j	5	16	expressed	express	VERB
r207tm7310j	5	17	on	on	ADP
r207tm7310j	5	18	cancers	cancer	NOUN
r207tm7310j	5	19	of	of	ADP
r207tm7310j	5	20	hematopoietic	hematopoietic	ADJ
r207tm7310j	5	21	origin	origin	NOUN
r207tm7310j	5	22	and	and	CCONJ
r207tm7310j	5	23	plays	play	VERB
r207tm7310j	5	24	a	a	DET
r207tm7310j	5	25	vital	vital	ADJ
r207tm7310j	5	26	role	role	NOUN
r207tm7310j	5	27	in	in	ADP
r207tm7310j	5	28	the	the	DET
r207tm7310j	5	29	cell	cell	NOUN
r207tm7310j	5	30	adhesion	adhesion	NOUN
r207tm7310j	5	31	mediated	mediate	VERB
r207tm7310j	5	32	drug	drug	NOUN
r207tm7310j	5	33	resistance	resistance	NOUN
r207tm7310j	5	34	(	(	PUNCT
r207tm7310j	5	35	cam	cam	PROPN
r207tm7310j	5	36	-	-	PUNCT
r207tm7310j	5	37	dr	dr	PROPN
r207tm7310j	5	38	)	)	PUNCT
r207tm7310j	5	39	in	in	ADP
r207tm7310j	5	40	mm	mm	PROPN
r207tm7310j	5	41	.	.	PUNCT
r207tm7310j	6	1	therefore	therefore	ADV
r207tm7310j	6	2	,	,	PUNCT
r207tm7310j	6	3	vla-4	vla-4	ADP
r207tm7310j	6	4	antagonist	antagonist	NOUN
r207tm7310j	6	5	peptides	peptide	NOUN
r207tm7310j	6	6	were	be	AUX
r207tm7310j	6	7	conjugated	conjugate	VERB
r207tm7310j	6	8	onto	onto	ADP
r207tm7310j	6	9	the	the	DET
r207tm7310j	6	10	nanoparticles	nanoparticle	NOUN
r207tm7310j	6	11	via	via	ADP
r207tm7310j	6	12	a	a	DET
r207tm7310j	6	13	multifaceted	multifaceted	ADJ
r207tm7310j	6	14	procedure	procedure	NOUN
r207tm7310j	6	15	to	to	PART
r207tm7310j	6	16	actively	actively	ADV
r207tm7310j	6	17	target	target	VERB
r207tm7310j	6	18	mm	mm	NOUN
r207tm7310j	6	19	cells	cell	NOUN
r207tm7310j	6	20	and	and	CCONJ
r207tm7310j	6	21	simultaneously	simultaneously	ADV
r207tm7310j	6	22	inhibit	inhibit	VERB
r207tm7310j	6	23	cam	cam	NOUN
r207tm7310j	6	24	-	-	PUNCT
r207tm7310j	6	25	dr	dr	PROPN
r207tm7310j	6	26	.	.	PUNCT
r207tm7310j	7	1	the	the	DET
r207tm7310j	7	2	micellar	micellar	ADJ
r207tm7310j	7	3	doxorubicin	doxorubicin	NOUN
r207tm7310j	7	4	nanoparticles	nanoparticle	NOUN
r207tm7310j	7	5	were	be	AUX
r207tm7310j	7	6	able	able	ADJ
r207tm7310j	7	7	to	to	PART
r207tm7310j	7	8	overcome	overcome	VERB
r207tm7310j	7	9	cam	cam	NOUN
r207tm7310j	7	10	-	-	PUNCT
r207tm7310j	7	11	dr	dr	PROPN
r207tm7310j	7	12	and	and	CCONJ
r207tm7310j	7	13	demonstrated	demonstrate	VERB
r207tm7310j	7	14	improved	improved	ADJ
r207tm7310j	7	15	therapeutic	therapeutic	ADJ
r207tm7310j	7	16	index	index	NOUN
r207tm7310j	7	17	relative	relative	ADJ
r207tm7310j	7	18	to	to	ADP
r207tm7310j	7	19	free	free	ADJ
r207tm7310j	7	20	doxorubicin	doxorubicin	NOUN
r207tm7310j	7	21	.	.	PUNCT
r207tm7310j	8	1	in	in	ADP
r207tm7310j	8	2	addition	addition	NOUN
r207tm7310j	8	3	to	to	ADP
r207tm7310j	8	4	doxorubicin	doxorubicin	NOUN
r207tm7310j	8	5	,	,	PUNCT
r207tm7310j	8	6	other	other	ADJ
r207tm7310j	8	7	classes	class	NOUN
r207tm7310j	8	8	of	of	ADP
r207tm7310j	8	9	therapeutic	therapeutic	ADJ
r207tm7310j	8	10	agents	agent	NOUN
r207tm7310j	8	11	,	,	PUNCT
r207tm7310j	8	12	such	such	ADJ
r207tm7310j	8	13	as	as	ADP
r207tm7310j	8	14	proteasome	proteasome	NOUN
r207tm7310j	8	15	inhibitors	inhibitor	NOUN
r207tm7310j	8	16	,	,	PUNCT
r207tm7310j	8	17	can	can	AUX
r207tm7310j	8	18	be	be	AUX
r207tm7310j	8	19	incorporated	incorporate	VERB
r207tm7310j	8	20	in	in	ADP
r207tm7310j	8	21	nanoparticles	nanoparticle	NOUN
r207tm7310j	8	22	for	for	ADP
r207tm7310j	8	23	improved	improved	ADJ
r207tm7310j	8	24	therapeutic	therapeutic	ADJ
r207tm7310j	8	25	outcomes	outcome	NOUN
r207tm7310j	8	26	.	.	PUNCT
r207tm7310j	9	1	utilizing	utilize	VERB
r207tm7310j	9	2	boronic	boronic	ADJ
r207tm7310j	9	3	acid	acid	NOUN
r207tm7310j	9	4	chemistry	chemistry	NOUN
r207tm7310j	9	5	,	,	PUNCT
r207tm7310j	9	6	bortezomib	bortezomib	NOUN
r207tm7310j	9	7	prodrugs	prodrug	NOUN
r207tm7310j	9	8	were	be	AUX
r207tm7310j	9	9	synthesized	synthesize	VERB
r207tm7310j	9	10	using	use	VERB
r207tm7310j	9	11	a	a	DET
r207tm7310j	9	12	reversible	reversible	ADJ
r207tm7310j	9	13	boronic	boronic	ADJ
r207tm7310j	9	14	ester	ester	NOUN
r207tm7310j	9	15	bond	bond	NOUN
r207tm7310j	9	16	and	and	CCONJ
r207tm7310j	9	17	then	then	ADV
r207tm7310j	9	18	incorporated	incorporate	VERB
r207tm7310j	9	19	into	into	ADP
r207tm7310j	9	20	liposomes	liposome	NOUN
r207tm7310j	9	21	.	.	PUNCT
r207tm7310j	10	1	the	the	DET
r207tm7310j	10	2	different	different	ADJ
r207tm7310j	10	3	boronic	boronic	ADJ
r207tm7310j	10	4	ester	ester	NOUN
r207tm7310j	10	5	bonds	bond	NOUN
r207tm7310j	10	6	that	that	PRON
r207tm7310j	10	7	could	could	AUX
r207tm7310j	10	8	be	be	AUX
r207tm7310j	10	9	potentially	potentially	ADV
r207tm7310j	10	10	used	use	VERB
r207tm7310j	10	11	in	in	ADP
r207tm7310j	10	12	the	the	DET
r207tm7310j	10	13	synthesis	synthesis	NOUN
r207tm7310j	10	14	of	of	ADP
r207tm7310j	10	15	bortezomib	bortezomib	NOUN
r207tm7310j	10	16	prodrugs	prodrug	NOUN
r207tm7310j	10	17	were	be	AUX
r207tm7310j	10	18	screened	screen	VERB
r207tm7310j	10	19	based	base	VERB
r207tm7310j	10	20	on	on	ADP
r207tm7310j	10	21	stability	stability	NOUN
r207tm7310j	10	22	using	use	VERB
r207tm7310j	10	23	isobutylboronic	isobutylboronic	ADJ
r207tm7310j	10	24	acid	acid	NOUN
r207tm7310j	10	25	.	.	PUNCT
r207tm7310j	11	1	the	the	DET
r207tm7310j	11	2	liposomal	liposomal	ADJ
r207tm7310j	11	3	bortezomib	bortezomib	NOUN
r207tm7310j	11	4	nanoparticles	nanoparticle	NOUN
r207tm7310j	11	5	demonstrated	demonstrate	VERB
r207tm7310j	11	6	significant	significant	ADJ
r207tm7310j	11	7	proteasome	proteasome	NOUN
r207tm7310j	11	8	inhibition	inhibition	NOUN
r207tm7310j	11	9	and	and	CCONJ
r207tm7310j	11	10	cytotoxicity	cytotoxicity	NOUN
r207tm7310j	11	11	in	in	ADP
r207tm7310j	11	12	mm	mm	NOUN
r207tm7310j	11	13	cells	cell	NOUN
r207tm7310j	11	14	in	in	ADP
r207tm7310j	11	15	vitro	vitro	X
r207tm7310j	11	16	,	,	PUNCT
r207tm7310j	11	17	and	and	CCONJ
r207tm7310j	11	18	dramatically	dramatically	ADV
r207tm7310j	11	19	reduced	reduce	VERB
r207tm7310j	11	20	the	the	DET
r207tm7310j	11	21	non	non	ADJ
r207tm7310j	11	22	-	-	ADJ
r207tm7310j	11	23	specific	specific	ADJ
r207tm7310j	11	24	toxicities	toxicity	NOUN
r207tm7310j	11	25	associated	associate	VERB
r207tm7310j	11	26	with	with	ADP
r207tm7310j	11	27	free	free	ADJ
r207tm7310j	11	28	bortezomib	bortezomib	NOUN
r207tm7310j	11	29	while	while	SCONJ
r207tm7310j	11	30	maintaining	maintain	VERB
r207tm7310j	11	31	significant	significant	ADJ
r207tm7310j	11	32	tumor	tumor	NOUN
r207tm7310j	11	33	growth	growth	NOUN
r207tm7310j	11	34	inhibition	inhibition	NOUN
r207tm7310j	11	35	in	in	ADP
r207tm7310j	11	36	vivo	vivo	PROPN
r207tm7310j	11	37	.	.	PUNCT
r207tm7310j	11	38	carfilzomib	carfilzomib	PROPN
r207tm7310j	11	39	,	,	PUNCT
r207tm7310j	11	40	another	another	DET
r207tm7310j	11	41	proteasome	proteasome	NOUN
r207tm7310j	11	42	inhibitor	inhibitor	NOUN
r207tm7310j	11	43	,	,	PUNCT
r207tm7310j	11	44	was	be	AUX
r207tm7310j	11	45	embedded	embed	VERB
r207tm7310j	11	46	into	into	ADP
r207tm7310j	11	47	the	the	DET
r207tm7310j	11	48	lipid	lipid	ADJ
r207tm7310j	11	49	bilayer	bilayer	NOUN
r207tm7310j	11	50	of	of	ADP
r207tm7310j	11	51	liposomes	liposome	NOUN
r207tm7310j	11	52	to	to	PART
r207tm7310j	11	53	improve	improve	VERB
r207tm7310j	11	54	its	its	PRON
r207tm7310j	11	55	therapeutic	therapeutic	ADJ
r207tm7310j	11	56	efficacy	efficacy	NOUN
r207tm7310j	11	57	.	.	PUNCT
r207tm7310j	12	1	vla-4	vla-4	ADP
r207tm7310j	12	2	antagonist	antagonist	NOUN
r207tm7310j	12	3	peptides	peptide	NOUN
r207tm7310j	12	4	were	be	AUX
r207tm7310j	12	5	also	also	ADV
r207tm7310j	12	6	incorporated	incorporate	VERB
r207tm7310j	12	7	to	to	PART
r207tm7310j	12	8	facilitate	facilitate	VERB
r207tm7310j	12	9	mm	mm	PROPN
r207tm7310j	12	10	cell	cell	NOUN
r207tm7310j	12	11	targeting	targeting	NOUN
r207tm7310j	12	12	and	and	CCONJ
r207tm7310j	12	13	uptake	uptake	NOUN
r207tm7310j	12	14	.	.	PUNCT
r207tm7310j	13	1	the	the	DET
r207tm7310j	13	2	liposomal	liposomal	ADJ
r207tm7310j	13	3	carfilzomib	carfilzomib	PROPN
r207tm7310j	13	4	nanoparticles	nanoparticle	NOUN
r207tm7310j	13	5	demonstrated	demonstrate	VERB
r207tm7310j	13	6	improved	improve	VERB
r207tm7310j	13	7	therapeutic	therapeutic	ADJ
r207tm7310j	13	8	index	index	NOUN
r207tm7310j	13	9	and	and	CCONJ
r207tm7310j	13	10	synergy	synergy	NOUN
r207tm7310j	13	11	with	with	ADP
r207tm7310j	13	12	doxorubicin	doxorubicin	PROPN
r207tm7310j	13	13	compared	compare	VERB
r207tm7310j	13	14	to	to	ADP
r207tm7310j	13	15	free	free	ADJ
r207tm7310j	13	16	carfilzomib	carfilzomib	NOUN
r207tm7310j	13	17	.	.	PUNCT
r207tm7310j	14	1	these	these	DET
r207tm7310j	14	2	nanoparticle	nanoparticle	NOUN
r207tm7310j	14	3	formulations	formulation	NOUN
r207tm7310j	14	4	can	can	AUX
r207tm7310j	14	5	significantly	significantly	ADV
r207tm7310j	14	6	improve	improve	VERB
r207tm7310j	14	7	the	the	DET
r207tm7310j	14	8	efficacy	efficacy	NOUN
r207tm7310j	14	9	of	of	ADP
r207tm7310j	14	10	the	the	DET
r207tm7310j	14	11	respective	respective	ADJ
r207tm7310j	14	12	therapeutic	therapeutic	ADJ
r207tm7310j	14	13	agents	agent	NOUN
r207tm7310j	14	14	and	and	CCONJ
r207tm7310j	14	15	have	have	VERB
r207tm7310j	14	16	an	an	DET
r207tm7310j	14	17	immense	immense	ADJ
r207tm7310j	14	18	potential	potential	NOUN
r207tm7310j	14	19	to	to	PART
r207tm7310j	14	20	positively	positively	ADV
r207tm7310j	14	21	impact	impact	VERB
r207tm7310j	14	22	the	the	DET
r207tm7310j	14	23	treatment	treatment	NOUN
r207tm7310j	14	24	of	of	ADP
r207tm7310j	14	25	mm	mm	PROPN
r207tm7310j	14	26	providing	provide	VERB
r207tm7310j	14	27	for	for	ADP
r207tm7310j	14	28	improved	improved	ADJ
r207tm7310j	14	29	patient	patient	ADJ
r207tm7310j	14	30	outcomes	outcome	NOUN
r207tm7310j	14	31	.	.	PUNCT