id	sid	tid	token	lemma	pos
qz20sq89r9h	1	1	the	the	DET
qz20sq89r9h	1	2	epothilones	epothilone	NOUN
qz20sq89r9h	1	3	are	be	AUX
qz20sq89r9h	1	4	anticancer	anticancer	ADJ
qz20sq89r9h	1	5	agents	agent	NOUN
qz20sq89r9h	1	6	that	that	PRON
qz20sq89r9h	1	7	stabilize	stabilize	VERB
qz20sq89r9h	1	8	microtubules	microtubule	NOUN
qz20sq89r9h	1	9	by	by	ADP
qz20sq89r9h	1	10	binding	bind	VERB
qz20sq89r9h	1	11	within	within	ADP
qz20sq89r9h	1	12	the	the	DET
qz20sq89r9h	1	13	paclitaxel	paclitaxel	NOUN
qz20sq89r9h	1	14	binding	bind	VERB
qz20sq89r9h	1	15	site	site	NOUN
qz20sq89r9h	1	16	in	in	ADP
qz20sq89r9h	1	17	ì_å_-tubulin	ì_å_-tubulin	PROPN
qz20sq89r9h	1	18	;	;	PUNCT
qz20sq89r9h	1	19	their	their	PRON
qz20sq89r9h	1	20	mechanism	mechanism	NOUN
qz20sq89r9h	1	21	of	of	ADP
qz20sq89r9h	1	22	action	action	NOUN
qz20sq89r9h	1	23	is	be	AUX
qz20sq89r9h	1	24	analogous	analogous	ADJ
qz20sq89r9h	1	25	to	to	ADP
qz20sq89r9h	1	26	that	that	PRON
qz20sq89r9h	1	27	of	of	ADP
qz20sq89r9h	1	28	taxolìâå¨.	taxolìâå¨.	PROPN
qz20sq89r9h	1	29	the	the	DET
qz20sq89r9h	1	30	structure	structure	NOUN
qz20sq89r9h	1	31	-	-	PUNCT
qz20sq89r9h	1	32	activity	activity	NOUN
qz20sq89r9h	1	33	relationships	relationship	NOUN
qz20sq89r9h	1	34	(	(	PUNCT
qz20sq89r9h	1	35	sar	sar	X
qz20sq89r9h	1	36	)	)	PUNCT
qz20sq89r9h	1	37	of	of	ADP
qz20sq89r9h	1	38	epothilones	epothilone	NOUN
qz20sq89r9h	1	39	have	have	AUX
qz20sq89r9h	1	40	been	be	AUX
qz20sq89r9h	1	41	extensively	extensively	ADV
qz20sq89r9h	1	42	investigated	investigate	VERB
qz20sq89r9h	1	43	.	.	PUNCT
qz20sq89r9h	2	1	our	our	PRON
qz20sq89r9h	2	2	contributions	contribution	NOUN
qz20sq89r9h	2	3	to	to	ADP
qz20sq89r9h	2	4	these	these	DET
qz20sq89r9h	2	5	sar	sar	PROPN
qz20sq89r9h	2	6	studies	study	NOUN
qz20sq89r9h	2	7	have	have	AUX
qz20sq89r9h	2	8	emphasized	emphasize	VERB
qz20sq89r9h	2	9	the	the	DET
qz20sq89r9h	2	10	role	role	NOUN
qz20sq89r9h	2	11	conformation	conformation	NOUN
qz20sq89r9h	2	12	plays	play	VERB
qz20sq89r9h	2	13	in	in	ADP
qz20sq89r9h	2	14	biological	biological	ADJ
qz20sq89r9h	2	15	function	function	NOUN
qz20sq89r9h	2	16	.	.	PUNCT
qz20sq89r9h	3	1	conformational	conformational	ADJ
qz20sq89r9h	3	2	analysis	analysis	NOUN
qz20sq89r9h	3	3	predicts	predict	VERB
qz20sq89r9h	3	4	two	two	NUM
qz20sq89r9h	3	5	major	major	ADJ
qz20sq89r9h	3	6	conformations	conformation	NOUN
qz20sq89r9h	3	7	for	for	ADP
qz20sq89r9h	3	8	the	the	DET
qz20sq89r9h	3	9	epothilone	epothilone	PROPN
qz20sq89r9h	3	10	epoxide	epoxide	PROPN
qz20sq89r9h	3	11	/	/	SYM
qz20sq89r9h	3	12	olefinic	olefinic	ADJ
qz20sq89r9h	3	13	region	region	NOUN
qz20sq89r9h	3	14	.	.	PUNCT
qz20sq89r9h	4	1	some	some	DET
qz20sq89r9h	4	2	groups	group	NOUN
qz20sq89r9h	4	3	have	have	AUX
qz20sq89r9h	4	4	suggested	suggest	VERB
qz20sq89r9h	4	5	that	that	SCONJ
qz20sq89r9h	4	6	the	the	DET
qz20sq89r9h	4	7	bioactive	bioactive	ADJ
qz20sq89r9h	4	8	conformation	conformation	NOUN
qz20sq89r9h	4	9	of	of	ADP
qz20sq89r9h	4	10	this	this	DET
qz20sq89r9h	4	11	region	region	NOUN
qz20sq89r9h	4	12	most	most	ADV
qz20sq89r9h	4	13	closely	closely	ADV
qz20sq89r9h	4	14	resembles	resemble	VERB
qz20sq89r9h	4	15	conformer	conformer	NOUN
qz20sq89r9h	4	16	2	2	NUM
qz20sq89r9h	4	17	.	.	X
qz20sq89r9h	4	18	computational	computational	ADJ
qz20sq89r9h	4	19	methods	method	NOUN
qz20sq89r9h	4	20	and	and	CCONJ
qz20sq89r9h	4	21	high	high	ADJ
qz20sq89r9h	4	22	-	-	PUNCT
qz20sq89r9h	4	23	field	field	NOUN
qz20sq89r9h	4	24	nmr	nmr	NOUN
qz20sq89r9h	4	25	experiments	experiment	NOUN
qz20sq89r9h	4	26	on	on	ADP
qz20sq89r9h	4	27	the	the	DET
qz20sq89r9h	4	28	epothilone	epothilone	NOUN
qz20sq89r9h	4	29	pharmacophore	pharmacophore	NOUN
qz20sq89r9h	4	30	have	have	AUX
qz20sq89r9h	4	31	enabled	enable	VERB
qz20sq89r9h	4	32	us	we	PRON
qz20sq89r9h	4	33	to	to	PART
qz20sq89r9h	4	34	distinguish	distinguish	VERB
qz20sq89r9h	4	35	epoxide	epoxide	NOUN
qz20sq89r9h	4	36	/	/	SYM
qz20sq89r9h	4	37	olefinic	olefinic	ADJ
qz20sq89r9h	4	38	conformer	conformer	NOUN
qz20sq89r9h	4	39	i	i	PRON
qz20sq89r9h	4	40	and	and	CCONJ
qz20sq89r9h	4	41	epoxide	epoxide	NOUN
qz20sq89r9h	4	42	/	/	SYM
qz20sq89r9h	4	43	olefinic	olefinic	ADJ
qz20sq89r9h	4	44	conformer	conformer	PROPN
qz20sq89r9h	4	45	ii	ii	PROPN
qz20sq89r9h	4	46	and	and	CCONJ
qz20sq89r9h	4	47	,	,	PUNCT
qz20sq89r9h	4	48	subsequently	subsequently	ADV
qz20sq89r9h	4	49	,	,	PUNCT
qz20sq89r9h	4	50	to	to	PART
qz20sq89r9h	4	51	determine	determine	VERB
qz20sq89r9h	4	52	which	which	PRON
qz20sq89r9h	4	53	most	most	ADV
qz20sq89r9h	4	54	accurately	accurately	ADV
qz20sq89r9h	4	55	describes	describe	VERB
qz20sq89r9h	4	56	the	the	DET
qz20sq89r9h	4	57	bioactive	bioactive	ADJ
qz20sq89r9h	4	58	conformation	conformation	NOUN
qz20sq89r9h	4	59	for	for	ADP
qz20sq89r9h	4	60	this	this	DET
qz20sq89r9h	4	61	region	region	NOUN
qz20sq89r9h	4	62	.	.	PUNCT
qz20sq89r9h	5	1	we	we	PRON
qz20sq89r9h	5	2	have	have	AUX
qz20sq89r9h	5	3	confirmed	confirm	VERB
qz20sq89r9h	5	4	through	through	ADP
qz20sq89r9h	5	5	computer	computer	NOUN
qz20sq89r9h	5	6	modeling	modeling	NOUN
qz20sq89r9h	5	7	techniques	technique	NOUN
qz20sq89r9h	5	8	that	that	PRON
qz20sq89r9h	5	9	(	(	PUNCT
qz20sq89r9h	5	10	14s)and	14s)and	PROPN
qz20sq89r9h	5	11	(	(	PUNCT
qz20sq89r9h	5	12	14r)-methyl	14r)-methyl	NUM
qz20sq89r9h	5	13	epothilone	epothilone	NOUN
qz20sq89r9h	5	14	d	d	PROPN
qz20sq89r9h	5	15	preferentially	preferentially	ADV
qz20sq89r9h	5	16	exist	exist	VERB
qz20sq89r9h	5	17	as	as	ADP
qz20sq89r9h	5	18	epoxide	epoxide	NOUN
qz20sq89r9h	5	19	/	/	SYM
qz20sq89r9h	5	20	olefinic	olefinic	ADJ
qz20sq89r9h	5	21	conformer	conformer	NOUN
qz20sq89r9h	5	22	i	i	PRON
qz20sq89r9h	5	23	and	and	CCONJ
qz20sq89r9h	5	24	epoxide	epoxide	NOUN
qz20sq89r9h	5	25	/	/	SYM
qz20sq89r9h	5	26	olefinic	olefinic	ADJ
qz20sq89r9h	5	27	conformer	conformer	PROPN
qz20sq89r9h	5	28	ii	ii	PROPN
qz20sq89r9h	5	29	,	,	PUNCT
qz20sq89r9h	5	30	correspondingly	correspondingly	ADV
qz20sq89r9h	5	31	.	.	PUNCT
qz20sq89r9h	6	1	moreover	moreover	ADV
qz20sq89r9h	6	2	,	,	PUNCT
qz20sq89r9h	6	3	the	the	DET
qz20sq89r9h	6	4	c14	c14	NOUN
qz20sq89r9h	6	5	-	-	PUNCT
qz20sq89r9h	6	6	methyl	methyl	NOUN
qz20sq89r9h	6	7	substituent	substituent	NOUN
qz20sq89r9h	6	8	destabilizes	destabilize	VERB
qz20sq89r9h	6	9	the	the	DET
qz20sq89r9h	6	10	surrogate	surrogate	ADJ
qz20sq89r9h	6	11	conformer	conformer	NOUN
qz20sq89r9h	6	12	.	.	PUNCT
qz20sq89r9h	7	1	(	(	PUNCT
qz20sq89r9h	7	2	14s)-methyl	14s)-methyl	NUM
qz20sq89r9h	7	3	epothilone	epothilone	NOUN
qz20sq89r9h	7	4	d	d	NOUN
qz20sq89r9h	7	5	exhibits	exhibit	VERB
qz20sq89r9h	7	6	biological	biological	ADJ
qz20sq89r9h	7	7	activity	activity	NOUN
qz20sq89r9h	7	8	against	against	ADP
qz20sq89r9h	7	9	several	several	ADJ
qz20sq89r9h	7	10	human	human	ADJ
qz20sq89r9h	7	11	cancer	cancer	NOUN
qz20sq89r9h	7	12	cell	cell	NOUN
qz20sq89r9h	7	13	lines	line	NOUN
qz20sq89r9h	7	14	analogous	analogous	ADJ
qz20sq89r9h	7	15	to	to	ADP
qz20sq89r9h	7	16	the	the	DET
qz20sq89r9h	7	17	naturally	naturally	ADV
qz20sq89r9h	7	18	occurring	occurring	ADJ
qz20sq89r9h	7	19	epothilones	epothilone	NOUN
qz20sq89r9h	7	20	;	;	PUNCT
qz20sq89r9h	7	21	however	however	ADV
qz20sq89r9h	7	22	,	,	PUNCT
qz20sq89r9h	7	23	(	(	PUNCT
qz20sq89r9h	7	24	14r)-methyl	14r)-methyl	NUM
qz20sq89r9h	7	25	epothilone	epothilone	NOUN
qz20sq89r9h	7	26	d	d	NOUN
qz20sq89r9h	7	27	retains	retain	VERB
qz20sq89r9h	7	28	no	no	DET
qz20sq89r9h	7	29	significant	significant	ADJ
qz20sq89r9h	7	30	cytotoxicity	cytotoxicity	NOUN
qz20sq89r9h	7	31	.	.	PUNCT
qz20sq89r9h	8	1	herein	herein	ADV
qz20sq89r9h	8	2	,	,	PUNCT
qz20sq89r9h	8	3	we	we	PRON
qz20sq89r9h	8	4	have	have	AUX
qz20sq89r9h	8	5	employed	employ	VERB
qz20sq89r9h	8	6	a	a	DET
qz20sq89r9h	8	7	concise	concise	ADJ
qz20sq89r9h	8	8	,	,	PUNCT
qz20sq89r9h	8	9	efficient	efficient	ADJ
qz20sq89r9h	8	10	second	second	ADJ
qz20sq89r9h	8	11	generation	generation	NOUN
qz20sq89r9h	8	12	synthesis	synthesis	NOUN
qz20sq89r9h	8	13	of	of	ADP
qz20sq89r9h	8	14	our	our	PRON
qz20sq89r9h	8	15	designed	design	VERB
qz20sq89r9h	8	16	,	,	PUNCT
qz20sq89r9h	8	17	c14	c14	NOUN
qz20sq89r9h	8	18	-	-	PUNCT
qz20sq89r9h	8	19	methylated	methylate	VERB
qz20sq89r9h	8	20	epothilone	epothilone	NOUN
qz20sq89r9h	8	21	d	d	NOUN
qz20sq89r9h	8	22	analogues	analogue	NOUN
qz20sq89r9h	8	23	that	that	PRON
qz20sq89r9h	8	24	shortens	shorten	VERB
qz20sq89r9h	8	25	our	our	PRON
qz20sq89r9h	8	26	synthetic	synthetic	ADJ
qz20sq89r9h	8	27	route	route	NOUN
qz20sq89r9h	8	28	by	by	ADP
qz20sq89r9h	8	29	two	two	NUM
qz20sq89r9h	8	30	steps	step	NOUN
qz20sq89r9h	8	31	and	and	CCONJ
qz20sq89r9h	8	32	circumvents	circumvent	VERB
qz20sq89r9h	8	33	some	some	PRON
qz20sq89r9h	8	34	of	of	ADP
qz20sq89r9h	8	35	the	the	DET
qz20sq89r9h	8	36	difficulties	difficulty	NOUN
qz20sq89r9h	8	37	associated	associate	VERB
qz20sq89r9h	8	38	with	with	ADP
qz20sq89r9h	8	39	our	our	PRON
qz20sq89r9h	8	40	first	first	ADJ
qz20sq89r9h	8	41	generation	generation	NOUN
qz20sq89r9h	8	42	synthetic	synthetic	ADJ
qz20sq89r9h	8	43	route	route	NOUN
qz20sq89r9h	8	44	.	.	PUNCT
qz20sq89r9h	9	1	subsequently	subsequently	ADV
qz20sq89r9h	9	2	,	,	PUNCT
qz20sq89r9h	9	3	we	we	PRON
qz20sq89r9h	9	4	investigated	investigate	VERB
qz20sq89r9h	9	5	their	their	PRON
qz20sq89r9h	9	6	binding	binding	ADJ
qz20sq89r9h	9	7	interactions	interaction	NOUN
qz20sq89r9h	9	8	with	with	ADP
qz20sq89r9h	9	9	tubulin	tubulin	NOUN
qz20sq89r9h	9	10	,	,	PUNCT
qz20sq89r9h	9	11	including	include	VERB
qz20sq89r9h	9	12	elucidating	elucidate	VERB
qz20sq89r9h	9	13	their	their	PRON
qz20sq89r9h	9	14	thermodynamic	thermodynamic	ADJ
qz20sq89r9h	9	15	binding	bind	VERB
qz20sq89r9h	9	16	parameters	parameter	NOUN
qz20sq89r9h	9	17	.	.	PUNCT
qz20sq89r9h	10	1	these	these	DET
qz20sq89r9h	10	2	studies	study	NOUN
qz20sq89r9h	10	3	demonstrated	demonstrate	VERB
qz20sq89r9h	10	4	that	that	SCONJ
qz20sq89r9h	10	5	(	(	PUNCT
qz20sq89r9h	10	6	14s)-methyl	14s)-methyl	NUM
qz20sq89r9h	10	7	epothilone	epothilone	NOUN
qz20sq89r9h	10	8	d	d	PROPN
qz20sq89r9h	10	9	incites	incites	PROPN
qz20sq89r9h	10	10	microtubule	microtubule	PROPN
qz20sq89r9h	10	11	polymerization	polymerization	NOUN
qz20sq89r9h	10	12	and	and	CCONJ
qz20sq89r9h	10	13	binds	bind	VERB
qz20sq89r9h	10	14	to	to	ADP
qz20sq89r9h	10	15	the	the	DET
qz20sq89r9h	10	16	paclitaxel	paclitaxel	NOUN
qz20sq89r9h	10	17	binding	bind	VERB
qz20sq89r9h	10	18	site	site	NOUN
qz20sq89r9h	10	19	(	(	PUNCT
qz20sq89r9h	10	20	kapp	kapp	PROPN
qz20sq89r9h	10	21	=	=	PROPN
qz20sq89r9h	10	22	1.2	1.2	NUM
qz20sq89r9h	10	23	x	x	SYM
qz20sq89r9h	10	24	107	107	NUM
qz20sq89r9h	10	25	m-1	m-1	NUM
qz20sq89r9h	10	26	at	at	ADP
qz20sq89r9h	10	27	37oc	37oc	PROPN
qz20sq89r9h	10	28	)	)	PUNCT
qz20sq89r9h	10	29	.	.	PUNCT
qz20sq89r9h	11	1	in	in	ADP
qz20sq89r9h	11	2	contrast	contrast	NOUN
qz20sq89r9h	11	3	,	,	PUNCT
qz20sq89r9h	11	4	(	(	PUNCT
qz20sq89r9h	11	5	14r)-methyl	14r)-methyl	NUM
qz20sq89r9h	11	6	epothilone	epothilone	NOUN
qz20sq89r9h	11	7	d	d	NOUN
qz20sq89r9h	11	8	does	do	AUX
qz20sq89r9h	11	9	not	not	PART
qz20sq89r9h	11	10	incite	incite	VERB
qz20sq89r9h	11	11	microtubule	microtubule	NOUN
qz20sq89r9h	11	12	polymerization	polymerization	NOUN
qz20sq89r9h	11	13	and	and	CCONJ
qz20sq89r9h	11	14	does	do	AUX
qz20sq89r9h	11	15	not	not	PART
qz20sq89r9h	11	16	show	show	VERB
qz20sq89r9h	11	17	any	any	DET
qz20sq89r9h	11	18	appreciable	appreciable	ADJ
qz20sq89r9h	11	19	affinity	affinity	NOUN
qz20sq89r9h	11	20	for	for	ADP
qz20sq89r9h	11	21	the	the	DET
qz20sq89r9h	11	22	paclitaxel	paclitaxel	NOUN
qz20sq89r9h	11	23	binding	bind	VERB
qz20sq89r9h	11	24	site	site	NOUN
qz20sq89r9h	11	25	.	.	PUNCT
qz20sq89r9h	12	1	these	these	DET
qz20sq89r9h	12	2	data	datum	NOUN
qz20sq89r9h	12	3	provide	provide	VERB
qz20sq89r9h	12	4	additional	additional	ADJ
qz20sq89r9h	12	5	evidence	evidence	NOUN
qz20sq89r9h	12	6	towards	towards	ADP
qz20sq89r9h	12	7	the	the	DET
qz20sq89r9h	12	8	bioactive	bioactive	ADJ
qz20sq89r9h	12	9	conformation	conformation	NOUN
qz20sq89r9h	12	10	of	of	ADP
qz20sq89r9h	12	11	the	the	DET
qz20sq89r9h	12	12	epoxide	epoxide	NOUN
qz20sq89r9h	12	13	/	/	SYM
qz20sq89r9h	12	14	olefinic	olefinic	ADJ
qz20sq89r9h	12	15	region	region	NOUN
qz20sq89r9h	12	16	of	of	ADP
qz20sq89r9h	12	17	the	the	DET
qz20sq89r9h	12	18	epothilone	epothilone	NOUN
qz20sq89r9h	12	19	class	class	NOUN
qz20sq89r9h	12	20	of	of	ADP
qz20sq89r9h	12	21	natural	natural	ADJ
qz20sq89r9h	12	22	products	product	NOUN
qz20sq89r9h	12	23	and	and	CCONJ
qz20sq89r9h	12	24	suggests	suggest	VERB
qz20sq89r9h	12	25	that	that	SCONJ
qz20sq89r9h	12	26	the	the	DET
qz20sq89r9h	12	27	bioactive	bioactive	ADJ
qz20sq89r9h	12	28	conformation	conformation	NOUN
qz20sq89r9h	12	29	of	of	ADP
qz20sq89r9h	12	30	the	the	DET
qz20sq89r9h	12	31	epoxide	epoxide	NOUN
qz20sq89r9h	12	32	/	/	SYM
qz20sq89r9h	12	33	olefinic	olefinic	ADJ
qz20sq89r9h	12	34	region	region	NOUN
qz20sq89r9h	12	35	is	be	AUX
qz20sq89r9h	12	36	,	,	PUNCT
qz20sq89r9h	12	37	indeed	indeed	ADV
qz20sq89r9h	12	38	,	,	PUNCT
qz20sq89r9h	12	39	epoxide	epoxide	NOUN
qz20sq89r9h	12	40	/	/	SYM
qz20sq89r9h	12	41	olefinic	olefinic	ADJ
qz20sq89r9h	12	42	conformer	conformer	NOUN
qz20sq89r9h	12	43	i	i	PRON
qz20sq89r9h	12	44	and	and	CCONJ
qz20sq89r9h	12	45	is	be	AUX
qz20sq89r9h	12	46	most	most	ADV
qz20sq89r9h	12	47	similar	similar	ADJ
qz20sq89r9h	12	48	to	to	ADP
qz20sq89r9h	12	49	that	that	PRON
qz20sq89r9h	12	50	adopted	adopt	VERB
qz20sq89r9h	12	51	by	by	ADP
qz20sq89r9h	12	52	(	(	PUNCT
qz20sq89r9h	12	53	14s)-methyl	14s)-methyl	NUM
qz20sq89r9h	12	54	epothilone	epothilone	NOUN
qz20sq89r9h	12	55	d.	d.	PROPN