id sid tid token lemma pos qz20sq89r85 1 1 plasmodium plasmodium NOUN qz20sq89r85 1 2 falciparum falciparum NOUN qz20sq89r85 1 3 malaria malaria NOUN qz20sq89r85 1 4 is be AUX qz20sq89r85 1 5 responsible responsible ADJ qz20sq89r85 1 6 for for ADP qz20sq89r85 1 7 severe severe ADJ qz20sq89r85 1 8 morbidity morbidity NOUN qz20sq89r85 1 9 and and CCONJ qz20sq89r85 1 10 mortality mortality NOUN qz20sq89r85 1 11 throughout throughout ADP qz20sq89r85 1 12 the the DET qz20sq89r85 1 13 world world NOUN qz20sq89r85 1 14 . . PUNCT qz20sq89r85 2 1 anti anti ADJ qz20sq89r85 2 2 - - NOUN qz20sq89r85 2 3 malarials malarial NOUN qz20sq89r85 2 4 used use VERB qz20sq89r85 2 5 to to PART qz20sq89r85 2 6 treat treat VERB qz20sq89r85 2 7 malaria malaria NOUN qz20sq89r85 2 8 , , PUNCT qz20sq89r85 2 9 such such ADJ qz20sq89r85 2 10 as as ADP qz20sq89r85 2 11 chloroquine chloroquine NOUN qz20sq89r85 2 12 ( ( PUNCT qz20sq89r85 2 13 cq cq PROPN qz20sq89r85 2 14 ) ) PUNCT qz20sq89r85 2 15 , , PUNCT qz20sq89r85 2 16 exhibit exhibit VERB qz20sq89r85 2 17 increased increase VERB qz20sq89r85 2 18 failure failure NOUN qz20sq89r85 2 19 and and CCONJ qz20sq89r85 2 20 have have VERB qz20sq89r85 2 21 an an DET qz20sq89r85 2 22 effect effect NOUN qz20sq89r85 2 23 on on ADP qz20sq89r85 2 24 the the DET qz20sq89r85 2 25 parasite parasite NOUN qz20sq89r85 2 26 genome genome NOUN qz20sq89r85 2 27 potentially potentially ADV qz20sq89r85 2 28 resulting result VERB qz20sq89r85 2 29 in in ADP qz20sq89r85 2 30 differences difference NOUN qz20sq89r85 2 31 in in ADP qz20sq89r85 2 32 parasite parasite NOUN qz20sq89r85 2 33 growth growth NOUN qz20sq89r85 2 34 . . PUNCT qz20sq89r85 3 1 differences difference NOUN qz20sq89r85 3 2 in in ADP qz20sq89r85 3 3 erythrocytic erythrocytic ADJ qz20sq89r85 3 4 growth growth NOUN qz20sq89r85 3 5 rates rate NOUN qz20sq89r85 3 6 between between ADP qz20sq89r85 3 7 parasite parasite NOUN qz20sq89r85 3 8 clones clone NOUN qz20sq89r85 3 9 affect affect VERB qz20sq89r85 3 10 parasite parasite NOUN qz20sq89r85 3 11 virulence virulence NOUN qz20sq89r85 3 12 ( ( PUNCT qz20sq89r85 3 13 chotivanich chotivanich PROPN qz20sq89r85 3 14 et et PROPN qz20sq89r85 3 15 al al PROPN qz20sq89r85 3 16 . . PROPN qz20sq89r85 3 17 , , PUNCT qz20sq89r85 3 18 2000 2000 NUM qz20sq89r85 3 19 ; ; PUNCT qz20sq89r85 3 20 dondorp dondorp PROPN qz20sq89r85 3 21 et et PROPN qz20sq89r85 3 22 al al PROPN qz20sq89r85 3 23 . . PROPN qz20sq89r85 3 24 , , PUNCT qz20sq89r85 3 25 2005 2005 NUM qz20sq89r85 3 26 ) ) PUNCT qz20sq89r85 3 27 . . PUNCT qz20sq89r85 4 1 parasite parasite NOUN qz20sq89r85 4 2 growth growth NOUN qz20sq89r85 4 3 is be AUX qz20sq89r85 4 4 complex complex ADJ qz20sq89r85 4 5 , , PUNCT qz20sq89r85 4 6 composed compose VERB qz20sq89r85 4 7 of of ADP qz20sq89r85 4 8 discrete discrete ADJ qz20sq89r85 4 9 biological biological ADJ qz20sq89r85 4 10 steps step NOUN qz20sq89r85 4 11 contributing contribute VERB qz20sq89r85 4 12 to to ADP qz20sq89r85 4 13 differences difference NOUN qz20sq89r85 4 14 in in ADP qz20sq89r85 4 15 overall overall ADJ qz20sq89r85 4 16 ' ' PUNCT qz20sq89r85 4 17 growth growth NOUN qz20sq89r85 4 18 . . PUNCT qz20sq89r85 4 19 ' ' PUNCT qz20sq89r85 5 1 to to PART qz20sq89r85 5 2 identify identify VERB qz20sq89r85 5 3 genes gene NOUN qz20sq89r85 5 4 and and CCONJ qz20sq89r85 5 5 mechanisms mechanism NOUN qz20sq89r85 5 6 regulating regulate VERB qz20sq89r85 5 7 differential differential ADJ qz20sq89r85 5 8 growth growth NOUN qz20sq89r85 5 9 , , PUNCT qz20sq89r85 5 10 a a DET qz20sq89r85 5 11 series series NOUN qz20sq89r85 5 12 of of ADP qz20sq89r85 5 13 phenotypes phenotype NOUN qz20sq89r85 5 14 ranging range VERB qz20sq89r85 5 15 from from ADP qz20sq89r85 5 16 bulk bulk ADJ qz20sq89r85 5 17 growth growth NOUN qz20sq89r85 5 18 ( ( PUNCT qz20sq89r85 5 19 e.g. e.g. X qz20sq89r85 5 20 blood blood NOUN qz20sq89r85 5 21 smears smear VERB qz20sq89r85 5 22 and and CCONJ qz20sq89r85 5 23 hx hx NOUN qz20sq89r85 5 24 - - PUNCT qz20sq89r85 5 25 incorporation incorporation NOUN qz20sq89r85 5 26 ) ) PUNCT qz20sq89r85 5 27 to to ADP qz20sq89r85 5 28 its its PRON qz20sq89r85 5 29 nested nest VERB qz20sq89r85 5 30 steps step NOUN qz20sq89r85 5 31 ( ( PUNCT qz20sq89r85 5 32 merozoite merozoite ADJ qz20sq89r85 5 33 production production NOUN qz20sq89r85 5 34 , , PUNCT qz20sq89r85 5 35 invasion invasion NOUN qz20sq89r85 5 36 efficiency efficiency NOUN qz20sq89r85 5 37 , , PUNCT qz20sq89r85 5 38 and and CCONJ qz20sq89r85 5 39 cycle cycle NOUN qz20sq89r85 5 40 time time NOUN qz20sq89r85 5 41 ) ) PUNCT qz20sq89r85 5 42 were be AUX qz20sq89r85 5 43 measured measure VERB qz20sq89r85 5 44 in in ADP qz20sq89r85 5 45 progeny progeny NOUN qz20sq89r85 5 46 of of ADP qz20sq89r85 5 47 a a DET qz20sq89r85 5 48 cross cross NOUN qz20sq89r85 5 49 between between ADP qz20sq89r85 5 50 a a DET qz20sq89r85 5 51 cq cq X qz20sq89r85 5 52 resistant resistant ADJ qz20sq89r85 5 53 and and CCONJ qz20sq89r85 5 54 cq cq ADP qz20sq89r85 5 55 sensitive sensitive ADJ qz20sq89r85 5 56 parasite parasite NOUN qz20sq89r85 5 57 , , PUNCT qz20sq89r85 5 58 dd2 dd2 NUM qz20sq89r85 5 59 and and CCONJ qz20sq89r85 5 60 hb3 hb3 NUM qz20sq89r85 5 61 respectively respectively ADV qz20sq89r85 5 62 , , PUNCT qz20sq89r85 5 63 and and CCONJ qz20sq89r85 5 64 used use VERB qz20sq89r85 5 65 in in ADP qz20sq89r85 5 66 quantitative quantitative ADJ qz20sq89r85 5 67 trait trait NOUN qz20sq89r85 5 68 loci locus NOUN qz20sq89r85 5 69 ( ( PUNCT qz20sq89r85 5 70 qtl qtl PROPN qz20sq89r85 5 71 ) ) PUNCT qz20sq89r85 5 72 mapping mapping NOUN qz20sq89r85 5 73 . . PUNCT qz20sq89r85 6 1 progeny progeny NOUN qz20sq89r85 6 2 exhibit exhibit VERB qz20sq89r85 6 3 quantitative quantitative ADJ qz20sq89r85 6 4 distributions distribution NOUN qz20sq89r85 6 5 of of ADP qz20sq89r85 6 6 growth growth NOUN qz20sq89r85 6 7 in in ADP qz20sq89r85 6 8 all all DET qz20sq89r85 6 9 five five NUM qz20sq89r85 6 10 growth growth NOUN qz20sq89r85 6 11 assays assay NOUN qz20sq89r85 6 12 . . PUNCT qz20sq89r85 7 1 significant significant ADJ qz20sq89r85 7 2 qtls qtls NOUN qz20sq89r85 7 3 from from ADP qz20sq89r85 7 4 the the DET qz20sq89r85 7 5 two two NUM qz20sq89r85 7 6 bulk bulk ADJ qz20sq89r85 7 7 growth growth NOUN qz20sq89r85 7 8 assays assay NOUN qz20sq89r85 7 9 and and CCONJ qz20sq89r85 7 10 cycle cycle NOUN qz20sq89r85 7 11 time time NOUN qz20sq89r85 7 12 produce produce VERB qz20sq89r85 7 13 a a DET qz20sq89r85 7 14 preliminary preliminary ADJ qz20sq89r85 7 15 list list NOUN qz20sq89r85 7 16 of of ADP qz20sq89r85 7 17 167 167 NUM qz20sq89r85 7 18 candidate candidate NOUN qz20sq89r85 7 19 genes gene NOUN qz20sq89r85 7 20 . . PUNCT qz20sq89r85 8 1 an an DET qz20sq89r85 8 2 unbiased unbiased ADJ qz20sq89r85 8 3 method method NOUN qz20sq89r85 8 4 using use VERB qz20sq89r85 8 5 whole whole ADJ qz20sq89r85 8 6 genome genome NOUN qz20sq89r85 8 7 datasets dataset NOUN qz20sq89r85 8 8 and and CCONJ qz20sq89r85 8 9 bioinformatics bioinformatic NOUN qz20sq89r85 8 10 was be AUX qz20sq89r85 8 11 developed develop VERB qz20sq89r85 8 12 to to PART qz20sq89r85 8 13 prioritize prioritize VERB qz20sq89r85 8 14 the the DET qz20sq89r85 8 15 list list NOUN qz20sq89r85 8 16 . . PUNCT qz20sq89r85 9 1 putative putative ADJ qz20sq89r85 9 2 functions function NOUN qz20sq89r85 9 3 were be AUX qz20sq89r85 9 4 assigned assign VERB qz20sq89r85 9 5 using use VERB qz20sq89r85 9 6 protein protein NOUN qz20sq89r85 9 7 network network NOUN qz20sq89r85 9 8 datasets dataset NOUN qz20sq89r85 9 9 , , PUNCT qz20sq89r85 9 10 gene gene NOUN qz20sq89r85 9 11 expression expression NOUN qz20sq89r85 9 12 correlations correlation NOUN qz20sq89r85 9 13 , , PUNCT qz20sq89r85 9 14 and and CCONJ qz20sq89r85 9 15 gene gene NOUN qz20sq89r85 9 16 ontology ontology NOUN qz20sq89r85 9 17 enrichment enrichment NOUN qz20sq89r85 9 18 resulting result VERB qz20sq89r85 9 19 in in ADP qz20sq89r85 9 20 a a DET qz20sq89r85 9 21 final final ADJ qz20sq89r85 9 22 list list NOUN qz20sq89r85 9 23 of of ADP qz20sq89r85 9 24 22 22 NUM qz20sq89r85 9 25 candidates candidate NOUN qz20sq89r85 9 26 . . PUNCT qz20sq89r85 10 1 a a DET qz20sq89r85 10 2 relationship relationship NOUN qz20sq89r85 10 3 between between ADP qz20sq89r85 10 4 parasite parasite NOUN qz20sq89r85 10 5 growth growth NOUN qz20sq89r85 10 6 and and CCONJ qz20sq89r85 10 7 drug drug NOUN qz20sq89r85 10 8 sensitivity sensitivity NOUN qz20sq89r85 10 9 is be AUX qz20sq89r85 10 10 observed observe VERB qz20sq89r85 10 11 in in ADP qz20sq89r85 10 12 cqr cqr NOUN qz20sq89r85 10 13 parasites parasite NOUN qz20sq89r85 10 14 but but CCONJ qz20sq89r85 10 15 not not PART qz20sq89r85 10 16 cqs cqs ADJ qz20sq89r85 10 17 parasites parasite NOUN qz20sq89r85 10 18 ; ; PUNCT qz20sq89r85 10 19 suggessting suggessting NOUN qz20sq89r85 10 20 cq cq PROPN qz20sq89r85 10 21 selection selection NOUN qz20sq89r85 10 22 has have AUX qz20sq89r85 10 23 altered alter VERB qz20sq89r85 10 24 the the DET qz20sq89r85 10 25 parasite parasite NOUN qz20sq89r85 10 26 genome genome NOUN qz20sq89r85 10 27 and and CCONJ qz20sq89r85 10 28 parasite parasite NOUN qz20sq89r85 10 29 fitness fitness NOUN qz20sq89r85 10 30 as as SCONJ qz20sq89r85 10 31 measured measure VERB qz20sq89r85 10 32 by by ADP qz20sq89r85 10 33 growth growth NOUN qz20sq89r85 10 34 . . PUNCT qz20sq89r85 11 1 progeny progeny NOUN qz20sq89r85 11 2 inheriting inheriting NOUN qz20sq89r85 11 3 'd would AUX qz20sq89r85 11 4 ' ' PUNCT qz20sq89r85 11 5 alleles allele NOUN qz20sq89r85 11 6 at at ADP qz20sq89r85 11 7 three three NUM qz20sq89r85 11 8 random random ADJ qz20sq89r85 11 9 markers marker NOUN qz20sq89r85 11 10 are be AUX qz20sq89r85 11 11 absent absent ADJ qz20sq89r85 11 12 less less ADV qz20sq89r85 11 13 often often ADV qz20sq89r85 11 14 compared compare VERB qz20sq89r85 11 15 to to ADP qz20sq89r85 11 16 progeny progeny NOUN qz20sq89r85 11 17 inheriting inherit VERB qz20sq89r85 11 18 mixed mixed ADJ qz20sq89r85 11 19 alleles allele NOUN qz20sq89r85 11 20 . . PUNCT qz20sq89r85 12 1 this this PRON qz20sq89r85 12 2 suggests suggest VERB qz20sq89r85 12 3 the the DET qz20sq89r85 12 4 dd2 dd2 PROPN qz20sq89r85 12 5 genome genome NOUN qz20sq89r85 12 6 is be AUX qz20sq89r85 12 7 fitter fitter ADJ qz20sq89r85 12 8 . . PUNCT qz20sq89r85 13 1 when when SCONJ qz20sq89r85 13 2 progeny progeny PROPN qz20sq89r85 13 3 inherit inherit VERB qz20sq89r85 13 4 a a DET qz20sq89r85 13 5 resistant resistant ADJ qz20sq89r85 13 6 pfcrt pfcrt NOUN qz20sq89r85 13 7 allele allele NOUN qz20sq89r85 13 8 , , PUNCT qz20sq89r85 13 9 there there PRON qz20sq89r85 13 10 is be VERB qz20sq89r85 13 11 an an DET qz20sq89r85 13 12 increase increase NOUN qz20sq89r85 13 13 in in ADP qz20sq89r85 13 14 the the DET qz20sq89r85 13 15 percent percent NOUN qz20sq89r85 13 16 of of ADP qz20sq89r85 13 17 absent absent ADJ qz20sq89r85 13 18 progeny progeny NOUN qz20sq89r85 13 19 with with ADP qz20sq89r85 13 20 'd 'd PROPN qz20sq89r85 13 21 ' ' PUNCT qz20sq89r85 13 22 alleles allele NOUN qz20sq89r85 13 23 at at ADP qz20sq89r85 13 24 three three NUM qz20sq89r85 13 25 markers marker NOUN qz20sq89r85 13 26 . . PUNCT qz20sq89r85 14 1 therefore therefore ADV qz20sq89r85 14 2 cq cq INTJ qz20sq89r85 14 3 resistant resistant ADJ qz20sq89r85 14 4 progeny progeny NOUN qz20sq89r85 14 5 suffer suffer VERB qz20sq89r85 14 6 from from ADP qz20sq89r85 14 7 a a DET qz20sq89r85 14 8 fitness fitness NOUN qz20sq89r85 14 9 cost cost NOUN qz20sq89r85 14 10 . . PUNCT qz20sq89r85 15 1 specific specific ADJ qz20sq89r85 15 2 alleles allele NOUN qz20sq89r85 15 3 implicated implicate VERB qz20sq89r85 15 4 in in ADP qz20sq89r85 15 5 the the DET qz20sq89r85 15 6 ' ' PUNCT qz20sq89r85 15 7 cqr cqr PROPN qz20sq89r85 15 8 background background NOUN qz20sq89r85 15 9 ' ' PUNCT qz20sq89r85 15 10 were be AUX qz20sq89r85 15 11 used use VERB qz20sq89r85 15 12 to to PART qz20sq89r85 15 13 ask ask VERB qz20sq89r85 15 14 about about ADP qz20sq89r85 15 15 parasite parasite NOUN qz20sq89r85 15 16 fitness fitness NOUN qz20sq89r85 15 17 and and CCONJ qz20sq89r85 15 18 lethality lethality NOUN qz20sq89r85 15 19 support support VERB qz20sq89r85 15 20 the the DET qz20sq89r85 15 21 idea idea NOUN qz20sq89r85 15 22 that that SCONJ qz20sq89r85 15 23 cq cq PROPN qz20sq89r85 15 24 selection selection NOUN qz20sq89r85 15 25 alters alter VERB qz20sq89r85 15 26 the the DET qz20sq89r85 15 27 parasite parasite NOUN qz20sq89r85 15 28 genome genome NOUN qz20sq89r85 15 29 by by ADP qz20sq89r85 15 30 causing cause VERB qz20sq89r85 15 31 compensatory compensatory ADJ qz20sq89r85 15 32 mutations mutation NOUN qz20sq89r85 15 33 in in ADP qz20sq89r85 15 34 response response NOUN qz20sq89r85 15 35 to to ADP qz20sq89r85 15 36 a a DET qz20sq89r85 15 37 cost cost NOUN qz20sq89r85 15 38 to to ADP qz20sq89r85 15 39 resistance resistance NOUN qz20sq89r85 15 40 . . PUNCT qz20sq89r85 16 1 these these DET qz20sq89r85 16 2 compensatory compensatory ADJ qz20sq89r85 16 3 mutations mutation NOUN qz20sq89r85 16 4 affect affect VERB qz20sq89r85 16 5 other other ADJ qz20sq89r85 16 6 parasite parasite NOUN qz20sq89r85 16 7 phenotypes phenotype NOUN qz20sq89r85 16 8 such such ADJ qz20sq89r85 16 9 as as ADP qz20sq89r85 16 10 growth growth NOUN qz20sq89r85 16 11 . . PUNCT qz20sq89r85 17 1 this this DET qz20sq89r85 17 2 hypothesis hypothesis NOUN qz20sq89r85 17 3 is be AUX qz20sq89r85 17 4 further far ADV qz20sq89r85 17 5 supported support VERB qz20sq89r85 17 6 by by ADP qz20sq89r85 17 7 observed observed ADJ qz20sq89r85 17 8 growth growth NOUN qz20sq89r85 17 9 differences difference NOUN qz20sq89r85 17 10 in in ADP qz20sq89r85 17 11 cq cq ADV qz20sq89r85 17 12 - - PUNCT qz20sq89r85 17 13 selected select VERB qz20sq89r85 17 14 mutant mutant ADJ qz20sq89r85 17 15 lines line NOUN qz20sq89r85 17 16 . . PUNCT