id	sid	tid	token	lemma	pos
qr46qz2370c	1	1	the	the	DET
qr46qz2370c	1	2	apcmin/+	apcmin/+	PROPN
qr46qz2370c	1	3	mouse	mouse	NOUN
qr46qz2370c	1	4	,	,	PUNCT
qr46qz2370c	1	5	a	a	DET
qr46qz2370c	1	6	genetic	genetic	ADJ
qr46qz2370c	1	7	model	model	NOUN
qr46qz2370c	1	8	of	of	ADP
qr46qz2370c	1	9	human	human	ADJ
qr46qz2370c	1	10	familial	familial	ADJ
qr46qz2370c	1	11	adenomatous	adenomatous	ADJ
qr46qz2370c	1	12	polyposis	polyposis	NOUN
qr46qz2370c	1	13	(	(	PUNCT
qr46qz2370c	1	14	fap	fap	NOUN
qr46qz2370c	1	15	)	)	PUNCT
qr46qz2370c	1	16	,	,	PUNCT
qr46qz2370c	1	17	was	be	AUX
qr46qz2370c	1	18	used	use	VERB
qr46qz2370c	1	19	in	in	ADP
qr46qz2370c	1	20	this	this	DET
qr46qz2370c	1	21	study	study	NOUN
qr46qz2370c	1	22	to	to	PART
qr46qz2370c	1	23	determine	determine	VERB
qr46qz2370c	1	24	effects	effect	NOUN
qr46qz2370c	1	25	of	of	ADP
qr46qz2370c	1	26	chemical	chemical	NOUN
qr46qz2370c	1	27	treatments	treatment	NOUN
qr46qz2370c	1	28	and	and	CCONJ
qr46qz2370c	1	29	genetic	genetic	ADJ
qr46qz2370c	1	30	alterations	alteration	NOUN
qr46qz2370c	1	31	on	on	ADP
qr46qz2370c	1	32	colon	colon	NOUN
qr46qz2370c	1	33	cancer	cancer	NOUN
qr46qz2370c	1	34	.	.	PUNCT
qr46qz2370c	2	1	non	non	ADJ
qr46qz2370c	2	2	-	-	ADJ
qr46qz2370c	2	3	steroidal	steroidal	ADJ
qr46qz2370c	2	4	anti	anti	ADJ
qr46qz2370c	2	5	-	-	ADJ
qr46qz2370c	2	6	inflammatory	inflammatory	ADJ
qr46qz2370c	2	7	drugs	drug	NOUN
qr46qz2370c	2	8	(	(	PUNCT
qr46qz2370c	2	9	nsaids	nsaids	PROPN
qr46qz2370c	2	10	)	)	PUNCT
qr46qz2370c	2	11	have	have	AUX
qr46qz2370c	2	12	shown	show	VERB
qr46qz2370c	2	13	potential	potential	NOUN
qr46qz2370c	2	14	as	as	ADP
qr46qz2370c	2	15	chemo	chemo	NOUN
qr46qz2370c	2	16	-	-	PUNCT
qr46qz2370c	2	17	preventive	preventive	ADJ
qr46qz2370c	2	18	agents	agent	NOUN
qr46qz2370c	2	19	against	against	ADP
qr46qz2370c	2	20	cancer	cancer	NOUN
qr46qz2370c	2	21	formation	formation	NOUN
qr46qz2370c	2	22	,	,	PUNCT
qr46qz2370c	2	23	especially	especially	ADV
qr46qz2370c	2	24	colorectal	colorectal	ADJ
qr46qz2370c	2	25	cancers	cancer	NOUN
qr46qz2370c	2	26	.	.	PUNCT
qr46qz2370c	3	1	however	however	ADV
qr46qz2370c	3	2	,	,	PUNCT
qr46qz2370c	3	3	the	the	DET
qr46qz2370c	3	4	mechanisms	mechanism	NOUN
qr46qz2370c	3	5	by	by	ADP
qr46qz2370c	3	6	which	which	PRON
qr46qz2370c	3	7	these	these	DET
qr46qz2370c	3	8	drugs	drug	NOUN
qr46qz2370c	3	9	act	act	VERB
qr46qz2370c	3	10	are	be	AUX
qr46qz2370c	3	11	not	not	PART
qr46qz2370c	3	12	fully	fully	ADV
qr46qz2370c	3	13	understood	understand	VERB
qr46qz2370c	3	14	.	.	PUNCT
qr46qz2370c	4	1	in	in	ADP
qr46qz2370c	4	2	this	this	DET
qr46qz2370c	4	3	study	study	NOUN
qr46qz2370c	4	4	,	,	PUNCT
qr46qz2370c	4	5	apcmin/+	apcmin/+	ADJ
qr46qz2370c	4	6	mice	mouse	NOUN
qr46qz2370c	4	7	were	be	AUX
qr46qz2370c	4	8	treated	treat	VERB
qr46qz2370c	4	9	with	with	ADP
qr46qz2370c	4	10	sulindac	sulindac	PROPN
qr46qz2370c	4	11	,	,	PUNCT
qr46qz2370c	4	12	a	a	DET
qr46qz2370c	4	13	nsaid	nsaid	NOUN
qr46qz2370c	4	14	that	that	SCONJ
qr46qz2370c	4	15	functions	function	NOUN
qr46qz2370c	4	16	as	as	ADP
qr46qz2370c	4	17	a	a	DET
qr46qz2370c	4	18	cyclooxygenase	cyclooxygenase	NOUN
qr46qz2370c	4	19	(	(	PUNCT
qr46qz2370c	4	20	cox	cox	PROPN
qr46qz2370c	4	21	)	)	PUNCT
qr46qz2370c	4	22	inhibitor	inhibitor	NOUN
qr46qz2370c	4	23	.	.	PUNCT
qr46qz2370c	5	1	these	these	DET
qr46qz2370c	5	2	mice	mouse	NOUN
qr46qz2370c	5	3	demonstrated	demonstrate	VERB
qr46qz2370c	5	4	a	a	DET
qr46qz2370c	5	5	tumor	tumor	NOUN
qr46qz2370c	5	6	reduction	reduction	NOUN
qr46qz2370c	5	7	of	of	ADP
qr46qz2370c	5	8	over	over	ADP
qr46qz2370c	5	9	80	80	NUM
qr46qz2370c	5	10	%	%	NOUN
qr46qz2370c	5	11	,	,	PUNCT
qr46qz2370c	5	12	consistent	consistent	ADJ
qr46qz2370c	5	13	with	with	ADP
qr46qz2370c	5	14	previous	previous	ADJ
qr46qz2370c	5	15	reports	report	NOUN
qr46qz2370c	5	16	.	.	PUNCT
qr46qz2370c	6	1	gene	gene	NOUN
qr46qz2370c	6	2	microarray	microarray	PROPN
qr46qz2370c	6	3	analyses	analysis	NOUN
qr46qz2370c	6	4	of	of	ADP
qr46qz2370c	6	5	rna	rna	NOUN
qr46qz2370c	6	6	from	from	ADP
qr46qz2370c	6	7	adenoma	adenoma	ADV
qr46qz2370c	6	8	-	-	PUNCT
qr46qz2370c	6	9	derived	derive	VERB
qr46qz2370c	6	10	dysplastic	dysplastic	ADJ
qr46qz2370c	6	11	epithelial	epithelial	ADJ
qr46qz2370c	6	12	cells	cell	NOUN
qr46qz2370c	6	13	revealed	reveal	VERB
qr46qz2370c	6	14	that	that	SCONJ
qr46qz2370c	6	15	collagen	collagen	NOUN
qr46qz2370c	6	16	genes	gene	NOUN
qr46qz2370c	6	17	,	,	PUNCT
qr46qz2370c	6	18	viz	viz	PROPN
qr46qz2370c	6	19	.	.	PROPN
qr46qz2370c	6	20	,	,	PUNCT
qr46qz2370c	6	21	col1a2	col1a2	PROPN
qr46qz2370c	6	22	,	,	PUNCT
qr46qz2370c	6	23	col5a2	col5a2	PROPN
qr46qz2370c	6	24	,	,	PUNCT
qr46qz2370c	6	25	col6a2	col6a2	PROPN
qr46qz2370c	6	26	,	,	PUNCT
qr46qz2370c	6	27	and	and	CCONJ
qr46qz2370c	6	28	col6a3	col6a3	PROPN
qr46qz2370c	6	29	,	,	PUNCT
qr46qz2370c	6	30	were	be	AUX
qr46qz2370c	6	31	upregulated	upregulate	VERB
qr46qz2370c	6	32	,	,	PUNCT
qr46qz2370c	6	33	and	and	CCONJ
qr46qz2370c	6	34	matrilysin	matrilysin	PROPN
qr46qz2370c	6	35	/	/	SYM
qr46qz2370c	6	36	metalloproteinase	metalloproteinase	PROPN
qr46qz2370c	6	37	7	7	NUM
qr46qz2370c	6	38	(	(	PUNCT
qr46qz2370c	6	39	mmp7	mmp7	PROPN
qr46qz2370c	6	40	)	)	PUNCT
qr46qz2370c	6	41	was	be	AUX
qr46qz2370c	6	42	downregulated	downregulate	VERB
qr46qz2370c	6	43	,	,	PUNCT
qr46qz2370c	6	44	in	in	ADP
qr46qz2370c	6	45	sulindac	sulindac	PROPN
qr46qz2370c	6	46	-	-	PUNCT
qr46qz2370c	6	47	treated	treat	VERB
qr46qz2370c	6	48	mice	mouse	NOUN
qr46qz2370c	6	49	.	.	PUNCT
qr46qz2370c	7	1	validation	validation	NOUN
qr46qz2370c	7	2	of	of	ADP
qr46qz2370c	7	3	the	the	DET
qr46qz2370c	7	4	gene	gene	NOUN
qr46qz2370c	7	5	expression	expression	NOUN
qr46qz2370c	7	6	profile	profile	NOUN
qr46qz2370c	7	7	of	of	ADP
qr46qz2370c	7	8	the	the	DET
qr46qz2370c	7	9	col6a2	col6a2	NOUN
qr46qz2370c	7	10	subunit	subunit	NOUN
qr46qz2370c	7	11	of	of	ADP
qr46qz2370c	7	12	collagen	collagen	PROPN
qr46qz2370c	7	13	vi	vi	PROPN
qr46qz2370c	7	14	and	and	CCONJ
qr46qz2370c	7	15	of	of	ADP
qr46qz2370c	7	16	mmp7	mmp7	PROPN
qr46qz2370c	7	17	was	be	AUX
qr46qz2370c	7	18	confirmed	confirm	VERB
qr46qz2370c	7	19	by	by	ADP
qr46qz2370c	7	20	rt	rt	NOUN
qr46qz2370c	7	21	-	-	PUNCT
qr46qz2370c	7	22	pcr	pcr	NOUN
qr46qz2370c	7	23	.	.	PUNCT
qr46qz2370c	8	1	confocal	confocal	ADJ
qr46qz2370c	8	2	microscopy	microscopy	NOUN
qr46qz2370c	8	3	and	and	CCONJ
qr46qz2370c	8	4	immunofluorescence	immunofluorescence	NOUN
qr46qz2370c	8	5	measurements	measurement	NOUN
qr46qz2370c	8	6	showed	show	VERB
qr46qz2370c	8	7	that	that	SCONJ
qr46qz2370c	8	8	collagen	collagen	PROPN
qr46qz2370c	8	9	vi	vi	PROPN
qr46qz2370c	8	10	was	be	AUX
qr46qz2370c	8	11	present	present	ADJ
qr46qz2370c	8	12	in	in	ADP
qr46qz2370c	8	13	low	low	ADJ
qr46qz2370c	8	14	amounts	amount	NOUN
qr46qz2370c	8	15	within	within	ADP
qr46qz2370c	8	16	the	the	DET
qr46qz2370c	8	17	tumors	tumor	NOUN
qr46qz2370c	8	18	of	of	ADP
qr46qz2370c	8	19	nontreated	nontreated	ADJ
qr46qz2370c	8	20	mice	mouse	NOUN
qr46qz2370c	8	21	,	,	PUNCT
qr46qz2370c	8	22	but	but	CCONJ
qr46qz2370c	8	23	was	be	AUX
qr46qz2370c	8	24	enhanced	enhance	VERB
qr46qz2370c	8	25	within	within	ADP
qr46qz2370c	8	26	the	the	DET
qr46qz2370c	8	27	tumors	tumor	NOUN
qr46qz2370c	8	28	of	of	ADP
qr46qz2370c	8	29	sulindac	sulindac	PROPN
qr46qz2370c	8	30	-	-	PUNCT
qr46qz2370c	8	31	treated	treat	VERB
qr46qz2370c	8	32	mice	mouse	NOUN
qr46qz2370c	8	33	.	.	PUNCT
qr46qz2370c	9	1	collagens	collagen	NOUN
qr46qz2370c	9	2	i	i	PRON
qr46qz2370c	9	3	and	and	CCONJ
qr46qz2370c	9	4	v	v	NOUN
qr46qz2370c	9	5	demonstrated	demonstrate	VERB
qr46qz2370c	9	6	similar	similar	ADJ
qr46qz2370c	9	7	patterns	pattern	NOUN
qr46qz2370c	9	8	,	,	PUNCT
qr46qz2370c	9	9	but	but	CCONJ
qr46qz2370c	9	10	were	be	AUX
qr46qz2370c	9	11	not	not	PART
qr46qz2370c	9	12	as	as	ADV
qr46qz2370c	9	13	prominent	prominent	ADJ
qr46qz2370c	9	14	as	as	ADP
qr46qz2370c	9	15	collagen	collagen	PROPN
qr46qz2370c	9	16	vi	vi	PROPN
qr46qz2370c	9	17	.	.	PROPN
qr46qz2370c	9	18	mmp7	mmp7	PROPN
qr46qz2370c	9	19	was	be	AUX
qr46qz2370c	9	20	found	find	VERB
qr46qz2370c	9	21	in	in	ADP
qr46qz2370c	9	22	'	'	PUNCT
qr46qz2370c	9	23	hot	hot	ADJ
qr46qz2370c	9	24	spot	spot	NOUN
qr46qz2370c	9	25	'	'	PART
qr46qz2370c	9	26	areas	area	NOUN
qr46qz2370c	9	27	within	within	ADP
qr46qz2370c	9	28	the	the	DET
qr46qz2370c	9	29	tumors	tumor	NOUN
qr46qz2370c	9	30	of	of	ADP
qr46qz2370c	9	31	apcmin/+	apcmin/+	NOUN
qr46qz2370c	9	32	mice	mouse	NOUN
qr46qz2370c	9	33	treated	treat	VERB
qr46qz2370c	9	34	with	with	ADP
qr46qz2370c	9	35	the	the	DET
qr46qz2370c	9	36	vehicle	vehicle	NOUN
qr46qz2370c	9	37	,	,	PUNCT
qr46qz2370c	9	38	but	but	CCONJ
qr46qz2370c	9	39	was	be	AUX
qr46qz2370c	9	40	greatly	greatly	ADV
qr46qz2370c	9	41	diminished	diminish	VERB
qr46qz2370c	9	42	in	in	ADP
qr46qz2370c	9	43	those	those	PRON
qr46qz2370c	9	44	treated	treat	VERB
qr46qz2370c	9	45	with	with	ADP
qr46qz2370c	9	46	sulindac	sulindac	PROPN
qr46qz2370c	9	47	.	.	PUNCT
qr46qz2370c	10	1	studies	study	NOUN
qr46qz2370c	10	2	with	with	ADP
qr46qz2370c	10	3	apcmin/+/mmp7-/double	apcmin/+/mmp7-/double	ADJ
qr46qz2370c	10	4	-	-	PUNCT
qr46qz2370c	10	5	deficient	deficient	ADJ
qr46qz2370c	10	6	mice	mouse	NOUN
qr46qz2370c	10	7	demonstrated	demonstrate	VERB
qr46qz2370c	10	8	a	a	DET
qr46qz2370c	10	9	reciprocal	reciprocal	ADJ
qr46qz2370c	10	10	relationship	relationship	NOUN
qr46qz2370c	10	11	of	of	ADP
qr46qz2370c	10	12	mmp7	mmp7	PROPN
qr46qz2370c	10	13	expression	expression	NOUN
qr46qz2370c	10	14	and	and	CCONJ
qr46qz2370c	10	15	the	the	DET
qr46qz2370c	10	16	levels	level	NOUN
qr46qz2370c	10	17	of	of	ADP
qr46qz2370c	10	18	these	these	DET
qr46qz2370c	10	19	three	three	NUM
qr46qz2370c	10	20	collagens	collagen	NOUN
qr46qz2370c	10	21	in	in	ADP
qr46qz2370c	10	22	vivo	vivo	PROPN
qr46qz2370c	10	23	.	.	PUNCT
qr46qz2370c	11	1	gene	gene	NOUN
qr46qz2370c	11	2	expression	expression	NOUN
qr46qz2370c	11	3	analysis	analysis	NOUN
qr46qz2370c	11	4	of	of	ADP
qr46qz2370c	11	5	the	the	DET
qr46qz2370c	11	6	human	human	ADJ
qr46qz2370c	11	7	colon	colon	NOUN
qr46qz2370c	11	8	cancer	cancer	NOUN
qr46qz2370c	11	9	cell	cell	NOUN
qr46qz2370c	11	10	line	line	NOUN
qr46qz2370c	11	11	,	,	PUNCT
qr46qz2370c	11	12	ht-29	ht-29	X
qr46qz2370c	11	13	,	,	PUNCT
qr46qz2370c	11	14	demonstrated	demonstrate	VERB
qr46qz2370c	11	15	that	that	SCONJ
qr46qz2370c	11	16	mmp7	mmp7	PROPN
qr46qz2370c	11	17	and	and	CCONJ
qr46qz2370c	11	18	hmgb1	hmgb1	PROPN
qr46qz2370c	11	19	were	be	AUX
qr46qz2370c	11	20	downregulated	downregulate	VERB
qr46qz2370c	11	21	after	after	ADP
qr46qz2370c	11	22	sulindac	sulindac	PROPN
qr46qz2370c	11	23	treatment	treatment	NOUN
qr46qz2370c	11	24	,	,	PUNCT
qr46qz2370c	11	25	resembling	resemble	VERB
qr46qz2370c	11	26	similar	similar	ADJ
qr46qz2370c	11	27	gene	gene	NOUN
qr46qz2370c	11	28	alterations	alteration	NOUN
qr46qz2370c	11	29	observed	observe	VERB
qr46qz2370c	11	30	in	in	ADP
qr46qz2370c	11	31	mice	mouse	NOUN
qr46qz2370c	11	32	.	.	PUNCT
qr46qz2370c	12	1	enzymatic	enzymatic	ADJ
qr46qz2370c	12	2	assays	assay	NOUN
qr46qz2370c	12	3	demonstrated	demonstrate	VERB
qr46qz2370c	12	4	that	that	SCONJ
qr46qz2370c	12	5	sulindac	sulindac	NOUN
qr46qz2370c	12	6	treatment	treatment	NOUN
qr46qz2370c	12	7	altered	alter	VERB
qr46qz2370c	12	8	gelatinase	gelatinase	NOUN
qr46qz2370c	12	9	activity	activity	NOUN
qr46qz2370c	12	10	.	.	PUNCT
qr46qz2370c	13	1	activity	activity	NOUN
qr46qz2370c	13	2	-	-	PUNCT
qr46qz2370c	13	3	based	base	VERB
qr46qz2370c	13	4	protein	protein	NOUN
qr46qz2370c	13	5	profiling	profiling	NOUN
qr46qz2370c	13	6	(	(	PUNCT
qr46qz2370c	13	7	abpp	abpp	PROPN
qr46qz2370c	13	8	)	)	PUNCT
qr46qz2370c	13	9	targeted	target	VERB
qr46qz2370c	13	10	to	to	ADP
qr46qz2370c	13	11	serine	serine	NOUN
qr46qz2370c	13	12	hydrolases	hydrolase	NOUN
qr46qz2370c	13	13	and	and	CCONJ
qr46qz2370c	13	14	metallohydrolases	metallohydrolase	NOUN
qr46qz2370c	13	15	revealed	reveal	VERB
qr46qz2370c	13	16	a	a	DET
qr46qz2370c	13	17	sulindac	sulindac	NOUN
qr46qz2370c	13	18	effect	effect	NOUN
qr46qz2370c	13	19	on	on	ADP
qr46qz2370c	13	20	many	many	ADJ
qr46qz2370c	13	21	members	member	NOUN
qr46qz2370c	13	22	of	of	ADP
qr46qz2370c	13	23	these	these	DET
qr46qz2370c	13	24	proteases	protease	NOUN
qr46qz2370c	13	25	.	.	PUNCT
qr46qz2370c	14	1	fas	fas	PROPN
qr46qz2370c	14	2	,	,	PUNCT
qr46qz2370c	14	3	a	a	DET
qr46qz2370c	14	4	member	member	NOUN
qr46qz2370c	14	5	of	of	ADP
qr46qz2370c	14	6	the	the	DET
qr46qz2370c	14	7	tumor	tumor	NOUN
qr46qz2370c	14	8	necrosis	necrosis	NOUN
qr46qz2370c	14	9	family	family	NOUN
qr46qz2370c	14	10	,	,	PUNCT
qr46qz2370c	14	11	is	be	AUX
qr46qz2370c	14	12	responsible	responsible	ADJ
qr46qz2370c	14	13	for	for	ADP
qr46qz2370c	14	14	initiating	initiate	VERB
qr46qz2370c	14	15	the	the	DET
qr46qz2370c	14	16	apoptotic	apoptotic	ADJ
qr46qz2370c	14	17	pathway	pathway	NOUN
qr46qz2370c	14	18	when	when	SCONJ
qr46qz2370c	14	19	bound	bind	VERB
qr46qz2370c	14	20	to	to	ADP
qr46qz2370c	14	21	its	its	PRON
qr46qz2370c	14	22	ligand	ligand	NOUN
qr46qz2370c	14	23	,	,	PUNCT
qr46qz2370c	14	24	fas	fas	PROPN
qr46qz2370c	14	25	-	-	PUNCT
qr46qz2370c	14	26	l.	l.	PROPN
qr46qz2370c	14	27	defects	defect	NOUN
qr46qz2370c	14	28	in	in	ADP
qr46qz2370c	14	29	the	the	DET
qr46qz2370c	14	30	fas	fas	PROPN
qr46qz2370c	14	31	-	-	PUNCT
qr46qz2370c	14	32	mediated	mediate	VERB
qr46qz2370c	14	33	apoptotic	apoptotic	ADJ
qr46qz2370c	14	34	pathway	pathway	NOUN
qr46qz2370c	14	35	have	have	AUX
qr46qz2370c	14	36	been	be	AUX
qr46qz2370c	14	37	reported	report	VERB
qr46qz2370c	14	38	in	in	ADP
qr46qz2370c	14	39	colorectal	colorectal	ADJ
qr46qz2370c	14	40	cancer	cancer	NOUN
qr46qz2370c	14	41	.	.	PUNCT
qr46qz2370c	15	1	in	in	ADP
qr46qz2370c	15	2	the	the	DET
qr46qz2370c	15	3	present	present	ADJ
qr46qz2370c	15	4	study	study	NOUN
qr46qz2370c	15	5	,	,	PUNCT
qr46qz2370c	15	6	a	a	DET
qr46qz2370c	15	7	variant	variant	NOUN
qr46qz2370c	15	8	of	of	ADP
qr46qz2370c	15	9	the	the	DET
qr46qz2370c	15	10	apcmin/+	apcmin/+	PROPN
qr46qz2370c	15	11	mouse	mouse	NOUN
qr46qz2370c	15	12	was	be	AUX
qr46qz2370c	15	13	generated	generate	VERB
qr46qz2370c	15	14	with	with	ADP
qr46qz2370c	15	15	an	an	DET
qr46qz2370c	15	16	additional	additional	ADJ
qr46qz2370c	15	17	deficiency	deficiency	NOUN
qr46qz2370c	15	18	of	of	ADP
qr46qz2370c	15	19	fas	fas	PROPN
qr46qz2370c	15	20	(	(	PUNCT
qr46qz2370c	15	21	apcmin/+/faslpr	apcmin/+/faslpr	PROPN
qr46qz2370c	15	22	)	)	PUNCT
qr46qz2370c	15	23	by	by	ADP
qr46qz2370c	15	24	multiple	multiple	ADJ
qr46qz2370c	15	25	cross	cros	NOUN
qr46qz2370c	15	26	-	-	NOUN
qr46qz2370c	15	27	breedings	breeding	NOUN
qr46qz2370c	15	28	of	of	ADP
qr46qz2370c	15	29	apcmin/+	apcmin/+	ADJ
qr46qz2370c	15	30	mice	mouse	NOUN
qr46qz2370c	15	31	with	with	ADP
qr46qz2370c	15	32	fas	fas	PROPN
qr46qz2370c	15	33	deficient	deficient	ADJ
qr46qz2370c	15	34	(	(	PUNCT
qr46qz2370c	15	35	faslpr	faslpr	PROPN
qr46qz2370c	15	36	)	)	PUNCT
qr46qz2370c	15	37	mice	mouse	NOUN
qr46qz2370c	15	38	.	.	PUNCT
qr46qz2370c	16	1	one	one	NUM
qr46qz2370c	16	2	of	of	ADP
qr46qz2370c	16	3	the	the	DET
qr46qz2370c	16	4	main	main	ADJ
qr46qz2370c	16	5	limitations	limitation	NOUN
qr46qz2370c	16	6	of	of	ADP
qr46qz2370c	16	7	the	the	DET
qr46qz2370c	16	8	apcmin/+	apcmin/+	PROPN
qr46qz2370c	16	9	mouse	mouse	NOUN
qr46qz2370c	16	10	model	model	NOUN
qr46qz2370c	16	11	is	be	AUX
qr46qz2370c	16	12	that	that	SCONJ
qr46qz2370c	16	13	it	it	PRON
qr46qz2370c	16	14	only	only	ADV
qr46qz2370c	16	15	develops	develop	VERB
qr46qz2370c	16	16	benign	benign	ADJ
qr46qz2370c	16	17	polyps	polyp	NOUN
qr46qz2370c	16	18	.	.	PUNCT
qr46qz2370c	17	1	however	however	ADV
qr46qz2370c	17	2	,	,	PUNCT
qr46qz2370c	17	3	apcmin/+/faslpr	apcmin/+/faslpr	ADJ
qr46qz2370c	17	4	mice	mouse	NOUN
qr46qz2370c	17	5	presented	present	VERB
qr46qz2370c	17	6	with	with	ADP
qr46qz2370c	17	7	dramatic	dramatic	ADJ
qr46qz2370c	17	8	increases	increase	NOUN
qr46qz2370c	17	9	in	in	ADP
qr46qz2370c	17	10	tumor	tumor	NOUN
qr46qz2370c	17	11	burden	burden	NOUN
qr46qz2370c	17	12	relative	relative	ADJ
qr46qz2370c	17	13	to	to	ADP
qr46qz2370c	17	14	apcmin/+	apcmin/+	NOUN
qr46qz2370c	17	15	mice	mouse	NOUN
qr46qz2370c	17	16	,	,	PUNCT
qr46qz2370c	17	17	with	with	ADP
qr46qz2370c	17	18	invasive	invasive	ADJ
qr46qz2370c	17	19	lesions	lesion	NOUN
qr46qz2370c	17	20	at	at	ADP
qr46qz2370c	17	21	advanced	advanced	ADJ
qr46qz2370c	17	22	ages	age	NOUN
qr46qz2370c	17	23	.	.	PUNCT
qr46qz2370c	18	1	proliferation	proliferation	NOUN
qr46qz2370c	18	2	and	and	CCONJ
qr46qz2370c	18	3	apoptosis	apoptosis	NOUN
qr46qz2370c	18	4	markers	marker	NOUN
qr46qz2370c	18	5	revealed	reveal	VERB
qr46qz2370c	18	6	an	an	DET
qr46qz2370c	18	7	increase	increase	NOUN
qr46qz2370c	18	8	in	in	ADP
qr46qz2370c	18	9	cellular	cellular	ADJ
qr46qz2370c	18	10	proliferation	proliferation	NOUN
qr46qz2370c	18	11	,	,	PUNCT
qr46qz2370c	18	12	but	but	CCONJ
qr46qz2370c	18	13	negligible	negligible	ADJ
qr46qz2370c	18	14	changes	change	NOUN
qr46qz2370c	18	15	in	in	ADP
qr46qz2370c	18	16	apoptosis	apoptosis	NOUN
qr46qz2370c	18	17	,	,	PUNCT
qr46qz2370c	18	18	while	while	SCONJ
qr46qz2370c	18	19	p53	p53	NOUN
qr46qz2370c	18	20	was	be	AUX
qr46qz2370c	18	21	enhanced	enhance	VERB
qr46qz2370c	18	22	at	at	ADP
qr46qz2370c	18	23	early	early	ADJ
qr46qz2370c	18	24	ages	age	NOUN
qr46qz2370c	18	25	.	.	PUNCT
qr46qz2370c	19	1	fas	fas	PROPN
qr46qz2370c	19	2	-	-	PROPN
qr46qz2370c	19	3	l	l	NOUN
qr46qz2370c	19	4	was	be	AUX
qr46qz2370c	19	5	lower	low	ADJ
qr46qz2370c	19	6	in	in	ADP
qr46qz2370c	19	7	apcmin/+/faslpr	apcmin/+/faslpr	ADJ
qr46qz2370c	19	8	mice	mouse	NOUN
qr46qz2370c	19	9	relative	relative	ADJ
qr46qz2370c	19	10	to	to	ADP
qr46qz2370c	19	11	apcmin/+	apcmin/+	NOUN
qr46qz2370c	19	12	cohorts	cohort	NOUN
qr46qz2370c	19	13	.	.	PUNCT
qr46qz2370c	20	1	the	the	DET
qr46qz2370c	20	2	results	result	NOUN
qr46qz2370c	20	3	of	of	ADP
qr46qz2370c	20	4	this	this	DET
qr46qz2370c	20	5	study	study	NOUN
qr46qz2370c	20	6	demonstrated	demonstrate	VERB
qr46qz2370c	20	7	that	that	SCONJ
qr46qz2370c	20	8	sulindac	sulindac	NOUN
qr46qz2370c	20	9	is	be	AUX
qr46qz2370c	20	10	effective	effective	ADJ
qr46qz2370c	20	11	in	in	ADP
qr46qz2370c	20	12	increasing	increase	VERB
qr46qz2370c	20	13	the	the	DET
qr46qz2370c	20	14	expression	expression	NOUN
qr46qz2370c	20	15	of	of	ADP
qr46qz2370c	20	16	different	different	ADJ
qr46qz2370c	20	17	collagens	collagen	NOUN
qr46qz2370c	20	18	and	and	CCONJ
qr46qz2370c	20	19	decreasing	decrease	VERB
qr46qz2370c	20	20	the	the	DET
qr46qz2370c	20	21	expression	expression	NOUN
qr46qz2370c	20	22	of	of	ADP
qr46qz2370c	20	23	mmp7	mmp7	PROPN
qr46qz2370c	20	24	and	and	CCONJ
qr46qz2370c	20	25	hmgb1	hmgb1	PROPN
qr46qz2370c	20	26	.	.	PUNCT
qr46qz2370c	21	1	these	these	DET
qr46qz2370c	21	2	effects	effect	NOUN
qr46qz2370c	21	3	are	be	AUX
qr46qz2370c	21	4	also	also	ADV
qr46qz2370c	21	5	seen	see	VERB
qr46qz2370c	21	6	in	in	ADP
qr46qz2370c	21	7	the	the	DET
qr46qz2370c	21	8	human	human	ADJ
qr46qz2370c	21	9	colon	colon	NOUN
qr46qz2370c	21	10	cancer	cancer	NOUN
qr46qz2370c	21	11	cell	cell	NOUN
qr46qz2370c	21	12	line	line	NOUN
qr46qz2370c	21	13	ht-29	ht-29	PART
qr46qz2370c	21	14	and	and	CCONJ
qr46qz2370c	21	15	may	may	AUX
qr46qz2370c	21	16	contribute	contribute	VERB
qr46qz2370c	21	17	to	to	ADP
qr46qz2370c	21	18	altered	alter	VERB
qr46qz2370c	21	19	tumor	tumor	NOUN
qr46qz2370c	21	20	burden	burden	NOUN
qr46qz2370c	21	21	in	in	ADP
qr46qz2370c	21	22	cancer	cancer	NOUN
qr46qz2370c	21	23	patients	patient	NOUN
qr46qz2370c	21	24	undergoing	undergo	VERB
qr46qz2370c	21	25	nsaids	nsaid	NOUN
qr46qz2370c	21	26	treatments	treatment	NOUN
qr46qz2370c	21	27	.	.	PUNCT
qr46qz2370c	22	1	it	it	PRON
qr46qz2370c	22	2	was	be	AUX
qr46qz2370c	22	3	also	also	ADV
qr46qz2370c	22	4	demonstrated	demonstrate	VERB
qr46qz2370c	22	5	that	that	SCONJ
qr46qz2370c	22	6	imposition	imposition	NOUN
qr46qz2370c	22	7	of	of	ADP
qr46qz2370c	22	8	a	a	DET
qr46qz2370c	22	9	fas	fas	NOUN
qr46qz2370c	22	10	deletion	deletion	NOUN
qr46qz2370c	22	11	in	in	ADP
qr46qz2370c	22	12	an	an	DET
qr46qz2370c	22	13	apcmin/+	apcmin/+	NOUN
qr46qz2370c	22	14	background	background	NOUN
qr46qz2370c	22	15	resulted	result	VERB
qr46qz2370c	22	16	in	in	ADP
qr46qz2370c	22	17	a	a	DET
qr46qz2370c	22	18	more	more	ADV
qr46qz2370c	22	19	aggressive	aggressive	ADJ
qr46qz2370c	22	20	phenotype	phenotype	NOUN
qr46qz2370c	22	21	of	of	ADP
qr46qz2370c	22	22	the	the	DET
qr46qz2370c	22	23	apcmin/+	apcmin/+	PROPN
qr46qz2370c	22	24	mouse	mouse	NOUN
qr46qz2370c	22	25	model	model	NOUN
qr46qz2370c	22	26	characterized	characterize	VERB
qr46qz2370c	22	27	by	by	ADP
qr46qz2370c	22	28	more	more	ADJ
qr46qz2370c	22	29	rapid	rapid	ADJ
qr46qz2370c	22	30	development	development	NOUN
qr46qz2370c	22	31	of	of	ADP
qr46qz2370c	22	32	invasive	invasive	ADJ
qr46qz2370c	22	33	intestinal	intestinal	ADJ
qr46qz2370c	22	34	tumors	tumor	NOUN
qr46qz2370c	22	35	and	and	CCONJ
qr46qz2370c	22	36	a	a	DET
qr46qz2370c	22	37	decrease	decrease	NOUN
qr46qz2370c	22	38	in	in	ADP
qr46qz2370c	22	39	fas	fas	PROPN
qr46qz2370c	22	40	-	-	PUNCT
qr46qz2370c	22	41	l	l	PROPN
qr46qz2370c	22	42	levels	level	NOUN
qr46qz2370c	22	43	.	.	PUNCT