id	sid	tid	token	lemma	pos
qb98mc90s4h	1	1	cardiovascular	cardiovascular	ADJ
qb98mc90s4h	1	2	diseases	disease	NOUN
qb98mc90s4h	1	3	(	(	PUNCT
qb98mc90s4h	1	4	cvds	cvds	PROPN
qb98mc90s4h	1	5	)	)	PUNCT
qb98mc90s4h	1	6	such	such	ADJ
qb98mc90s4h	1	7	as	as	ADP
qb98mc90s4h	1	8	myocardial	myocardial	ADJ
qb98mc90s4h	1	9	infarction	infarction	NOUN
qb98mc90s4h	1	10	are	be	AUX
qb98mc90s4h	1	11	the	the	DET
qb98mc90s4h	1	12	primary	primary	ADJ
qb98mc90s4h	1	13	cause	cause	NOUN
qb98mc90s4h	1	14	of	of	ADP
qb98mc90s4h	1	15	death	death	NOUN
qb98mc90s4h	1	16	worldwide	worldwide	ADV
qb98mc90s4h	1	17	.	.	PUNCT
qb98mc90s4h	2	1	the	the	DET
qb98mc90s4h	2	2	current	current	ADJ
qb98mc90s4h	2	3	clinical	clinical	ADJ
qb98mc90s4h	2	4	approach	approach	NOUN
qb98mc90s4h	2	5	after	after	SCONJ
qb98mc90s4h	2	6	mi	mi	PROPN
qb98mc90s4h	2	7	is	be	AUX
qb98mc90s4h	2	8	reoxygenating	reoxygenate	VERB
qb98mc90s4h	2	9	the	the	DET
qb98mc90s4h	2	10	infarct	infarct	NOUN
qb98mc90s4h	2	11	heart	heart	NOUN
qb98mc90s4h	2	12	tissue	tissue	NOUN
qb98mc90s4h	2	13	,	,	PUNCT
qb98mc90s4h	2	14	however	however	ADV
qb98mc90s4h	2	15	,	,	PUNCT
qb98mc90s4h	2	16	this	this	PRON
qb98mc90s4h	2	17	may	may	AUX
qb98mc90s4h	2	18	lead	lead	VERB
qb98mc90s4h	2	19	to	to	ADP
qb98mc90s4h	2	20	further	further	ADJ
qb98mc90s4h	2	21	damage	damage	NOUN
qb98mc90s4h	2	22	due	due	ADP
qb98mc90s4h	2	23	to	to	ADP
qb98mc90s4h	2	24	the	the	DET
qb98mc90s4h	2	25	oxidative	oxidative	ADJ
qb98mc90s4h	2	26	stress	stress	NOUN
qb98mc90s4h	2	27	created	create	VERB
qb98mc90s4h	2	28	,	,	PUNCT
qb98mc90s4h	2	29	causing	cause	VERB
qb98mc90s4h	2	30	reperfusion	reperfusion	NOUN
qb98mc90s4h	2	31	injury	injury	NOUN
qb98mc90s4h	2	32	(	(	PUNCT
qb98mc90s4h	2	33	ri	ri	PROPN
qb98mc90s4h	2	34	)	)	PUNCT
qb98mc90s4h	2	35	.	.	PUNCT
qb98mc90s4h	3	1	occurrence	occurrence	NOUN
qb98mc90s4h	3	2	of	of	ADP
qb98mc90s4h	3	3	cvds	cvds	PROPN
qb98mc90s4h	3	4	and	and	CCONJ
qb98mc90s4h	3	5	the	the	DET
qb98mc90s4h	3	6	related	related	ADJ
qb98mc90s4h	3	7	mortality	mortality	NOUN
qb98mc90s4h	3	8	drastically	drastically	ADV
qb98mc90s4h	3	9	increases	increase	VERB
qb98mc90s4h	3	10	with	with	ADP
qb98mc90s4h	3	11	age	age	NOUN
qb98mc90s4h	3	12	;	;	PUNCT
qb98mc90s4h	3	13	over	over	ADP
qb98mc90s4h	3	14	69	69	NUM
qb98mc90s4h	3	15	%	%	NOUN
qb98mc90s4h	3	16	of	of	ADP
qb98mc90s4h	3	17	patients	patient	NOUN
qb98mc90s4h	3	18	who	who	PRON
qb98mc90s4h	3	19	die	die	VERB
qb98mc90s4h	3	20	of	of	ADP
qb98mc90s4h	3	21	such	such	ADJ
qb98mc90s4h	3	22	diseases	disease	NOUN
qb98mc90s4h	3	23	are	be	AUX
qb98mc90s4h	3	24	age	age	NOUN
qb98mc90s4h	3	25	65	65	NUM
qb98mc90s4h	3	26	or	or	CCONJ
qb98mc90s4h	3	27	older	old	ADJ
qb98mc90s4h	3	28	.	.	PUNCT
qb98mc90s4h	4	1	therefore	therefore	ADV
qb98mc90s4h	4	2	,	,	PUNCT
qb98mc90s4h	4	3	having	have	VERB
qb98mc90s4h	4	4	a	a	DET
qb98mc90s4h	4	5	thorough	thorough	ADJ
qb98mc90s4h	4	6	understanding	understanding	NOUN
qb98mc90s4h	4	7	of	of	ADP
qb98mc90s4h	4	8	the	the	DET
qb98mc90s4h	4	9	pathophysiology	pathophysiology	NOUN
qb98mc90s4h	4	10	of	of	ADP
qb98mc90s4h	4	11	cvds	cvds	PROPN
qb98mc90s4h	4	12	in	in	ADP
qb98mc90s4h	4	13	the	the	DET
qb98mc90s4h	4	14	elderly	elderly	ADJ
qb98mc90s4h	4	15	population	population	NOUN
qb98mc90s4h	4	16	is	be	AUX
qb98mc90s4h	4	17	crucial	crucial	ADJ
qb98mc90s4h	4	18	.	.	PUNCT
qb98mc90s4h	5	1	most	most	ADJ
qb98mc90s4h	5	2	studies	study	NOUN
qb98mc90s4h	5	3	,	,	PUNCT
qb98mc90s4h	5	4	however	however	ADV
qb98mc90s4h	5	5	,	,	PUNCT
qb98mc90s4h	5	6	use	use	VERB
qb98mc90s4h	5	7	animal	animal	NOUN
qb98mc90s4h	5	8	models	model	NOUN
qb98mc90s4h	5	9	such	such	ADJ
qb98mc90s4h	5	10	as	as	ADP
qb98mc90s4h	5	11	mice	mouse	NOUN
qb98mc90s4h	5	12	or	or	CCONJ
qb98mc90s4h	5	13	rats	rat	NOUN
qb98mc90s4h	5	14	that	that	PRON
qb98mc90s4h	5	15	are	be	AUX
qb98mc90s4h	5	16	8	8	NUM
qb98mc90s4h	5	17	-	-	SYM
qb98mc90s4h	5	18	12	12	NUM
qb98mc90s4h	5	19	weeks	week	NOUN
qb98mc90s4h	5	20	old	old	ADJ
qb98mc90s4h	5	21	.	.	PUNCT
qb98mc90s4h	6	1	thus	thus	ADV
qb98mc90s4h	6	2	,	,	PUNCT
qb98mc90s4h	6	3	the	the	DET
qb98mc90s4h	6	4	drastic	drastic	ADJ
qb98mc90s4h	6	5	differences	difference	NOUN
qb98mc90s4h	6	6	brought	bring	VERB
qb98mc90s4h	6	7	by	by	ADP
qb98mc90s4h	6	8	age	age	NOUN
qb98mc90s4h	6	9	and	and	CCONJ
qb98mc90s4h	6	10	interspecies	interspecie	NOUN
qb98mc90s4h	6	11	differences	difference	NOUN
qb98mc90s4h	6	12	lead	lead	VERB
qb98mc90s4h	6	13	to	to	ADP
qb98mc90s4h	6	14	poor	poor	ADJ
qb98mc90s4h	6	15	success	success	NOUN
qb98mc90s4h	6	16	in	in	ADP
qb98mc90s4h	6	17	translating	translate	VERB
qb98mc90s4h	6	18	treatments	treatment	NOUN
qb98mc90s4h	6	19	to	to	ADP
qb98mc90s4h	6	20	the	the	DET
qb98mc90s4h	6	21	clinical	clinical	ADJ
qb98mc90s4h	6	22	settings	setting	NOUN
qb98mc90s4h	6	23	,	,	PUNCT
qb98mc90s4h	6	24	showing	show	VERB
qb98mc90s4h	6	25	the	the	DET
qb98mc90s4h	6	26	immense	immense	ADJ
qb98mc90s4h	6	27	need	need	NOUN
qb98mc90s4h	6	28	for	for	ADP
qb98mc90s4h	6	29	a	a	DET
qb98mc90s4h	6	30	more	more	ADV
qb98mc90s4h	6	31	pathologically	pathologically	ADV
qb98mc90s4h	6	32	relevant	relevant	ADJ
qb98mc90s4h	6	33	tissue	tissue	NOUN
qb98mc90s4h	6	34	/	/	SYM
qb98mc90s4h	6	35	disease	disease	NOUN
qb98mc90s4h	6	36	model	model	NOUN
qb98mc90s4h	6	37	.	.	PUNCT
qb98mc90s4h	7	1	using	use	VERB
qb98mc90s4h	7	2	tissue	tissue	NOUN
qb98mc90s4h	7	3	engineering	engineering	NOUN
qb98mc90s4h	7	4	,	,	PUNCT
qb98mc90s4h	7	5	highly	highly	ADV
qb98mc90s4h	7	6	controlled	control	VERB
qb98mc90s4h	7	7	yet	yet	CCONJ
qb98mc90s4h	7	8	complex	complex	ADJ
qb98mc90s4h	7	9	tissue	tissue	NOUN
qb98mc90s4h	7	10	level	level	NOUN
qb98mc90s4h	7	11	3	3	NUM
qb98mc90s4h	7	12	-	-	PUNCT
qb98mc90s4h	7	13	dimensional	dimensional	ADJ
qb98mc90s4h	7	14	systems	system	NOUN
qb98mc90s4h	7	15	can	can	AUX
qb98mc90s4h	7	16	be	be	AUX
qb98mc90s4h	7	17	developed	develop	VERB
qb98mc90s4h	7	18	.	.	PUNCT
qb98mc90s4h	8	1	such	such	ADJ
qb98mc90s4h	8	2	systems	system	NOUN
qb98mc90s4h	8	3	can	can	AUX
qb98mc90s4h	8	4	be	be	AUX
qb98mc90s4h	8	5	incorporated	incorporate	VERB
qb98mc90s4h	8	6	with	with	ADP
qb98mc90s4h	8	7	human	human	ADJ
qb98mc90s4h	8	8	induced	induce	VERB
qb98mc90s4h	8	9	pluripotent	pluripotent	ADJ
qb98mc90s4h	8	10	stem	stem	NOUN
qb98mc90s4h	8	11	cell	cell	NOUN
qb98mc90s4h	8	12	(	(	PUNCT
qb98mc90s4h	8	13	hipsc)-derived	hipsc)-derive	VERB
qb98mc90s4h	8	14	cells	cell	NOUN
qb98mc90s4h	8	15	to	to	PART
qb98mc90s4h	8	16	fabricate	fabricate	VERB
qb98mc90s4h	8	17	fully	fully	ADV
qb98mc90s4h	8	18	human	human	ADJ
qb98mc90s4h	8	19	-	-	PUNCT
qb98mc90s4h	8	20	origin	origin	NOUN
qb98mc90s4h	8	21	,	,	PUNCT
qb98mc90s4h	8	22	personalized	personalize	VERB
qb98mc90s4h	8	23	platforms.the	platforms.the	DET
qb98mc90s4h	8	24	main	main	ADJ
qb98mc90s4h	8	25	goal	goal	NOUN
qb98mc90s4h	8	26	of	of	ADP
qb98mc90s4h	8	27	this	this	DET
qb98mc90s4h	8	28	dissertation	dissertation	NOUN
qb98mc90s4h	8	29	was	be	AUX
qb98mc90s4h	8	30	to	to	PART
qb98mc90s4h	8	31	develop	develop	VERB
qb98mc90s4h	8	32	physiologically	physiologically	ADV
qb98mc90s4h	8	33	relevant	relevant	ADJ
qb98mc90s4h	8	34	,	,	PUNCT
qb98mc90s4h	8	35	aged	aged	ADJ
qb98mc90s4h	8	36	human	human	ADJ
qb98mc90s4h	8	37	-	-	PUNCT
qb98mc90s4h	8	38	origin	origin	NOUN
qb98mc90s4h	8	39	myocardial	myocardial	ADJ
qb98mc90s4h	8	40	tissue	tissue	NOUN
qb98mc90s4h	8	41	models	model	NOUN
qb98mc90s4h	8	42	to	to	PART
qb98mc90s4h	8	43	study	study	VERB
qb98mc90s4h	8	44	the	the	DET
qb98mc90s4h	8	45	pathology	pathology	NOUN
qb98mc90s4h	8	46	of	of	ADP
qb98mc90s4h	8	47	ri	ri	PROPN
qb98mc90s4h	8	48	.	.	PUNCT
qb98mc90s4h	9	1	towards	towards	ADP
qb98mc90s4h	9	2	that	that	DET
qb98mc90s4h	9	3	goal	goal	NOUN
qb98mc90s4h	9	4	,	,	PUNCT
qb98mc90s4h	9	5	we	we	PRON
qb98mc90s4h	9	6	first	first	ADV
qb98mc90s4h	9	7	determined	determine	VERB
qb98mc90s4h	9	8	the	the	DET
qb98mc90s4h	9	9	characteristics	characteristic	NOUN
qb98mc90s4h	9	10	of	of	ADP
qb98mc90s4h	9	11	aging	age	VERB
qb98mc90s4h	9	12	on	on	ADP
qb98mc90s4h	9	13	the	the	DET
qb98mc90s4h	9	14	tissue	tissue	NOUN
qb98mc90s4h	9	15	level	level	NOUN
qb98mc90s4h	9	16	and	and	CCONJ
qb98mc90s4h	9	17	observed	observe	VERB
qb98mc90s4h	9	18	that	that	SCONJ
qb98mc90s4h	9	19	aging	aging	NOUN
qb98mc90s4h	9	20	is	be	AUX
qb98mc90s4h	9	21	not	not	PART
qb98mc90s4h	9	22	just	just	ADV
qb98mc90s4h	9	23	the	the	DET
qb98mc90s4h	9	24	sum	sum	NOUN
qb98mc90s4h	9	25	of	of	ADP
qb98mc90s4h	9	26	cellular	cellular	ADJ
qb98mc90s4h	9	27	failures	failure	NOUN
qb98mc90s4h	9	28	,	,	PUNCT
qb98mc90s4h	9	29	but	but	CCONJ
qb98mc90s4h	9	30	it	it	PRON
qb98mc90s4h	9	31	is	be	AUX
qb98mc90s4h	9	32	an	an	DET
qb98mc90s4h	9	33	emergent	emergent	ADJ
qb98mc90s4h	9	34	event	event	NOUN
qb98mc90s4h	9	35	that	that	PRON
qb98mc90s4h	9	36	manifests	manifest	VERB
qb98mc90s4h	9	37	due	due	ADP
qb98mc90s4h	9	38	to	to	ADP
qb98mc90s4h	9	39	the	the	DET
qb98mc90s4h	9	40	interdependency	interdependency	NOUN
qb98mc90s4h	9	41	of	of	ADP
qb98mc90s4h	9	42	the	the	DET
qb98mc90s4h	9	43	cells	cell	NOUN
qb98mc90s4h	9	44	within	within	ADP
qb98mc90s4h	9	45	the	the	DET
qb98mc90s4h	9	46	tissue	tissue	NOUN
qb98mc90s4h	9	47	.	.	PUNCT
qb98mc90s4h	10	1	we	we	PRON
qb98mc90s4h	10	2	then	then	ADV
qb98mc90s4h	10	3	designed	design	VERB
qb98mc90s4h	10	4	and	and	CCONJ
qb98mc90s4h	10	5	fabricated	fabricate	VERB
qb98mc90s4h	10	6	myocardial	myocardial	ADJ
qb98mc90s4h	10	7	model	model	NOUN
qb98mc90s4h	10	8	tissues	tissue	NOUN
qb98mc90s4h	10	9	using	use	VERB
qb98mc90s4h	10	10	hipsc	hipsc	NOUN
qb98mc90s4h	10	11	-	-	PUNCT
qb98mc90s4h	10	12	derived	derive	VERB
qb98mc90s4h	10	13	endothelial	endothelial	ADJ
qb98mc90s4h	10	14	cells	cell	NOUN
qb98mc90s4h	10	15	(	(	PUNCT
qb98mc90s4h	10	16	ecs	ecs	PROPN
qb98mc90s4h	10	17	)	)	PUNCT
qb98mc90s4h	10	18	and	and	CCONJ
qb98mc90s4h	10	19	cardiomyocytes	cardiomyocyte	NOUN
qb98mc90s4h	10	20	(	(	PUNCT
qb98mc90s4h	10	21	cms	cms	NOUN
qb98mc90s4h	10	22	)	)	PUNCT
qb98mc90s4h	10	23	from	from	ADP
qb98mc90s4h	10	24	rats	rat	NOUN
qb98mc90s4h	10	25	to	to	PART
qb98mc90s4h	10	26	study	study	VERB
qb98mc90s4h	10	27	pathophysiology	pathophysiology	NOUN
qb98mc90s4h	10	28	and	and	CCONJ
qb98mc90s4h	10	29	potential	potential	ADJ
qb98mc90s4h	10	30	ameliorations	amelioration	NOUN
qb98mc90s4h	10	31	of	of	ADP
qb98mc90s4h	10	32	ri	ri	PROPN
qb98mc90s4h	10	33	.	.	PUNCT
qb98mc90s4h	11	1	we	we	PRON
qb98mc90s4h	11	2	showed	show	VERB
qb98mc90s4h	11	3	that	that	SCONJ
qb98mc90s4h	11	4	ec	ec	PROPN
qb98mc90s4h	11	5	-	-	PUNCT
qb98mc90s4h	11	6	cm	cm	PROPN
qb98mc90s4h	11	7	interactions	interaction	NOUN
qb98mc90s4h	11	8	and	and	CCONJ
qb98mc90s4h	11	9	hypoxia	hypoxia	NOUN
qb98mc90s4h	11	10	inducible	inducible	ADJ
qb98mc90s4h	11	11	factor	factor	NOUN
qb98mc90s4h	11	12	1	1	NUM
qb98mc90s4h	11	13	expression	expression	NOUN
qb98mc90s4h	11	14	in	in	ADP
qb98mc90s4h	11	15	ecs	ecs	NOUN
qb98mc90s4h	11	16	is	be	AUX
qb98mc90s4h	11	17	crucial	crucial	ADJ
qb98mc90s4h	11	18	for	for	ADP
qb98mc90s4h	11	19	myocardial	myocardial	ADJ
qb98mc90s4h	11	20	survival	survival	NOUN
qb98mc90s4h	11	21	under	under	ADP
qb98mc90s4h	11	22	ri	ri	PROPN
qb98mc90s4h	11	23	.	.	PROPN
qb98mc90s4h	12	1	using	use	VERB
qb98mc90s4h	12	2	whole	whole	ADJ
qb98mc90s4h	12	3	genome	genome	NOUN
qb98mc90s4h	12	4	transcriptome	transcriptome	NOUN
qb98mc90s4h	12	5	analysis	analysis	NOUN
qb98mc90s4h	12	6	,	,	PUNCT
qb98mc90s4h	12	7	we	we	PRON
qb98mc90s4h	12	8	showed	show	VERB
qb98mc90s4h	12	9	that	that	SCONJ
qb98mc90s4h	12	10	this	this	DET
qb98mc90s4h	12	11	protective	protective	ADJ
qb98mc90s4h	12	12	effect	effect	NOUN
qb98mc90s4h	12	13	is	be	AUX
qb98mc90s4h	12	14	governed	govern	VERB
qb98mc90s4h	12	15	by	by	ADP
qb98mc90s4h	12	16	ec	ec	PROPN
qb98mc90s4h	12	17	-	-	PUNCT
qb98mc90s4h	12	18	driven	drive	VERB
qb98mc90s4h	12	19	stabilization	stabilization	NOUN
qb98mc90s4h	12	20	of	of	ADP
qb98mc90s4h	12	21	mitochondrial	mitochondrial	ADJ
qb98mc90s4h	12	22	complexes	complex	NOUN
qb98mc90s4h	12	23	,	,	PUNCT
qb98mc90s4h	12	24	suppression	suppression	NOUN
qb98mc90s4h	12	25	of	of	ADP
qb98mc90s4h	12	26	oxidative	oxidative	ADJ
qb98mc90s4h	12	27	phosphorylation	phosphorylation	NOUN
qb98mc90s4h	12	28	,	,	PUNCT
qb98mc90s4h	12	29	and	and	CCONJ
qb98mc90s4h	12	30	activation	activation	NOUN
qb98mc90s4h	12	31	of	of	ADP
qb98mc90s4h	12	32	rap1	rap1	PROPN
qb98mc90s4h	12	33	signaling	signal	VERB
qb98mc90s4h	12	34	pathway	pathway	NOUN
qb98mc90s4h	12	35	.	.	PUNCT
qb98mc90s4h	13	1	finally	finally	ADV
qb98mc90s4h	13	2	,	,	PUNCT
qb98mc90s4h	13	3	we	we	PRON
qb98mc90s4h	13	4	developed	develop	VERB
qb98mc90s4h	13	5	the	the	DET
qb98mc90s4h	13	6	first	first	ADJ
qb98mc90s4h	13	7	in	in	ADP
qb98mc90s4h	13	8	vitro	vitro	X
qb98mc90s4h	13	9	aged	age	VERB
qb98mc90s4h	13	10	engineered	engineer	VERB
qb98mc90s4h	13	11	myocardium	myocardium	NOUN
qb98mc90s4h	13	12	which	which	PRON
qb98mc90s4h	13	13	shows	show	VERB
qb98mc90s4h	13	14	molecular	molecular	ADJ
qb98mc90s4h	13	15	and	and	CCONJ
qb98mc90s4h	13	16	functional	functional	ADJ
qb98mc90s4h	13	17	characteristics	characteristic	NOUN
qb98mc90s4h	13	18	resembling	resemble	VERB
qb98mc90s4h	13	19	aged	aged	ADJ
qb98mc90s4h	13	20	mammalian	mammalian	ADJ
qb98mc90s4h	13	21	heart	heart	NOUN
qb98mc90s4h	13	22	.	.	PUNCT
qb98mc90s4h	14	1	this	this	DET
qb98mc90s4h	14	2	novel	novel	NOUN
qb98mc90s4h	14	3	platform	platform	NOUN
qb98mc90s4h	14	4	showing	show	VERB
qb98mc90s4h	14	5	age	age	NOUN
qb98mc90s4h	14	6	-	-	PUNCT
qb98mc90s4h	14	7	appropriate	appropriate	ADJ
qb98mc90s4h	14	8	physiology	physiology	NOUN
qb98mc90s4h	14	9	and	and	CCONJ
qb98mc90s4h	14	10	pathology	pathology	NOUN
qb98mc90s4h	14	11	is	be	AUX
qb98mc90s4h	14	12	promising	promise	VERB
qb98mc90s4h	14	13	for	for	ADP
qb98mc90s4h	14	14	investigating	investigate	VERB
qb98mc90s4h	14	15	cvds	cvds	PROPN
qb98mc90s4h	14	16	or	or	CCONJ
qb98mc90s4h	14	17	other	other	ADJ
qb98mc90s4h	14	18	age	age	NOUN
qb98mc90s4h	14	19	-	-	PUNCT
qb98mc90s4h	14	20	related	relate	VERB
qb98mc90s4h	14	21	diseases	disease	NOUN
qb98mc90s4h	14	22	in	in	ADP
qb98mc90s4h	14	23	a	a	DET
qb98mc90s4h	14	24	time	time	NOUN
qb98mc90s4h	14	25	and	and	CCONJ
qb98mc90s4h	14	26	cost	cost	NOUN
qb98mc90s4h	14	27	-	-	PUNCT
qb98mc90s4h	14	28	effective	effective	ADJ
qb98mc90s4h	14	29	manner	manner	NOUN
qb98mc90s4h	14	30	.	.	PUNCT