id	sid	tid	token	lemma	pos
qb98mc9038p	1	1	isolated	isolate	VERB
qb98mc9038p	1	2	in	in	ADP
qb98mc9038p	1	3	1997	1997	NUM
qb98mc9038p	1	4	from	from	ADP
qb98mc9038p	1	5	the	the	DET
qb98mc9038p	1	6	bacteria	bacteria	NOUN
qb98mc9038p	1	7	,	,	PUNCT
qb98mc9038p	1	8	nocardiopsis	nocardiopsis	NOUN
qb98mc9038p	1	9	sp	sp	NOUN
qb98mc9038p	1	10	.	.	PROPN
qb98mc9038p	1	11	,	,	PUNCT
qb98mc9038p	1	12	apoptolidin	apoptolidin	ADJ
qb98mc9038p	1	13	was	be	AUX
qb98mc9038p	1	14	discovered	discover	VERB
qb98mc9038p	1	15	to	to	PART
qb98mc9038p	1	16	be	be	AUX
qb98mc9038p	1	17	remarkably	remarkably	ADV
qb98mc9038p	1	18	selective	selective	ADJ
qb98mc9038p	1	19	in	in	ADP
qb98mc9038p	1	20	killing	kill	VERB
qb98mc9038p	1	21	cells	cell	NOUN
qb98mc9038p	1	22	transformed	transform	VERB
qb98mc9038p	1	23	by	by	ADP
qb98mc9038p	1	24	the	the	DET
qb98mc9038p	1	25	adenovirus	adenovirus	NOUN
qb98mc9038p	1	26	e1a	e1a	DET
qb98mc9038p	1	27	oncogene	oncogene	NOUN
qb98mc9038p	1	28	while	while	SCONJ
qb98mc9038p	1	29	leaving	leave	VERB
qb98mc9038p	1	30	normal	normal	ADJ
qb98mc9038p	1	31	cells	cell	NOUN
qb98mc9038p	1	32	unharmed	unharmed	ADJ
qb98mc9038p	1	33	.	.	PUNCT
qb98mc9038p	2	1	apoptolidin	apoptolidin	VERB
qb98mc9038p	2	2	's	's	PART
qb98mc9038p	2	3	particularly	particularly	ADV
qb98mc9038p	2	4	interesting	interesting	ADJ
qb98mc9038p	2	5	mode	mode	NOUN
qb98mc9038p	2	6	of	of	ADP
qb98mc9038p	2	7	action	action	NOUN
qb98mc9038p	2	8	has	have	AUX
qb98mc9038p	2	9	been	be	AUX
qb98mc9038p	2	10	proposed	propose	VERB
qb98mc9038p	2	11	to	to	PART
qb98mc9038p	2	12	involve	involve	VERB
qb98mc9038p	2	13	inhibition	inhibition	NOUN
qb98mc9038p	2	14	of	of	ADP
qb98mc9038p	2	15	the	the	DET
qb98mc9038p	2	16	f1f0	f1f0	ADV
qb98mc9038p	2	17	-	-	PUNCT
qb98mc9038p	2	18	atp	atp	VERB
qb98mc9038p	2	19	synthase	synthase	NOUN
qb98mc9038p	2	20	found	find	VERB
qb98mc9038p	2	21	in	in	ADP
qb98mc9038p	2	22	the	the	DET
qb98mc9038p	2	23	inner	inner	ADJ
qb98mc9038p	2	24	-	-	PUNCT
qb98mc9038p	2	25	membrane	membrane	NOUN
qb98mc9038p	2	26	of	of	ADP
qb98mc9038p	2	27	the	the	DET
qb98mc9038p	2	28	mitochondria	mitochondria	PROPN
qb98mc9038p	2	29	.	.	PUNCT
qb98mc9038p	3	1	polyketide	polyketide	PROPN
qb98mc9038p	3	2	derived	derive	VERB
qb98mc9038p	3	3	,	,	PUNCT
qb98mc9038p	3	4	apoptolidin	apoptolidin	VERB
qb98mc9038p	3	5	,	,	PUNCT
qb98mc9038p	3	6	consists	consist	VERB
qb98mc9038p	3	7	of	of	ADP
qb98mc9038p	3	8	a	a	DET
qb98mc9038p	3	9	20	20	NUM
qb98mc9038p	3	10	-	-	PUNCT
qb98mc9038p	3	11	membered	membered	ADJ
qb98mc9038p	3	12	macrolide	macrolide	NOUN
qb98mc9038p	3	13	,	,	PUNCT
qb98mc9038p	3	14	highly	highly	ADV
qb98mc9038p	3	15	-	-	PUNCT
qb98mc9038p	3	16	substituted	substitute	VERB
qb98mc9038p	3	17	pyran	pyran	NOUN
qb98mc9038p	3	18	,	,	PUNCT
qb98mc9038p	3	19	and	and	CCONJ
qb98mc9038p	3	20	carbohydrate	carbohydrate	NOUN
qb98mc9038p	3	21	appendages	appendage	NOUN
qb98mc9038p	3	22	.	.	PUNCT
qb98mc9038p	4	1	because	because	SCONJ
qb98mc9038p	4	2	of	of	ADP
qb98mc9038p	4	3	this	this	DET
qb98mc9038p	4	4	structural	structural	ADJ
qb98mc9038p	4	5	complexity	complexity	NOUN
qb98mc9038p	4	6	and	and	CCONJ
qb98mc9038p	4	7	cytotoxicity	cytotoxicity	NOUN
qb98mc9038p	4	8	,	,	PUNCT
qb98mc9038p	4	9	apoptolidin	apoptolidin	ADJ
qb98mc9038p	4	10	has	have	AUX
qb98mc9038p	4	11	garner	garner	VERB
qb98mc9038p	4	12	considerable	considerable	ADJ
qb98mc9038p	4	13	interest	interest	NOUN
qb98mc9038p	4	14	in	in	ADP
qb98mc9038p	4	15	the	the	DET
qb98mc9038p	4	16	scientific	scientific	ADJ
qb98mc9038p	4	17	community	community	NOUN
qb98mc9038p	4	18	resulting	result	VERB
qb98mc9038p	4	19	in	in	ADP
qb98mc9038p	4	20	several	several	ADJ
qb98mc9038p	4	21	total	total	ADJ
qb98mc9038p	4	22	syntheses	synthesis	NOUN
qb98mc9038p	4	23	,	,	PUNCT
qb98mc9038p	4	24	sar	sar	PROPN
qb98mc9038p	4	25	work	work	NOUN
qb98mc9038p	4	26	,	,	PUNCT
qb98mc9038p	4	27	and	and	CCONJ
qb98mc9038p	4	28	further	further	ADJ
qb98mc9038p	4	29	isolations	isolation	NOUN
qb98mc9038p	4	30	of	of	ADP
qb98mc9038p	4	31	compounds	compound	NOUN
qb98mc9038p	4	32	in	in	ADP
qb98mc9038p	4	33	the	the	DET
qb98mc9038p	4	34	apoptolidin	apoptolidin	VERB
qb98mc9038p	4	35	family	family	NOUN
qb98mc9038p	4	36	.	.	PUNCT
qb98mc9038p	5	1	while	while	SCONJ
qb98mc9038p	5	2	working	work	VERB
qb98mc9038p	5	3	towards	towards	ADP
qb98mc9038p	5	4	the	the	DET
qb98mc9038p	5	5	total	total	ADJ
qb98mc9038p	5	6	synthesis	synthesis	NOUN
qb98mc9038p	5	7	of	of	ADP
qb98mc9038p	5	8	apoptolidinone	apoptolidinone	NOUN
qb98mc9038p	5	9	(	(	PUNCT
qb98mc9038p	5	10	apoptolidin	apoptolidin	VERB
qb98mc9038p	5	11	's	's	PART
qb98mc9038p	5	12	aglycone	aglycone	NOUN
qb98mc9038p	5	13	core	core	NOUN
qb98mc9038p	5	14	)	)	PUNCT
qb98mc9038p	5	15	,	,	PUNCT
qb98mc9038p	5	16	several	several	ADJ
qb98mc9038p	5	17	research	research	NOUN
qb98mc9038p	5	18	groups	group	NOUN
qb98mc9038p	5	19	discovered	discover	VERB
qb98mc9038p	5	20	at	at	ADP
qb98mc9038p	5	21	physiological	physiological	ADJ
qb98mc9038p	5	22	ph	ph	NOUN
qb98mc9038p	5	23	and	and	CCONJ
qb98mc9038p	5	24	temperature	temperature	NOUN
qb98mc9038p	5	25	,	,	PUNCT
qb98mc9038p	5	26	apoptolidin	apoptolidin	ADJ
qb98mc9038p	5	27	isomerizes	isomerize	NOUN
qb98mc9038p	5	28	to	to	ADP
qb98mc9038p	5	29	the	the	DET
qb98mc9038p	5	30	21	21	NUM
qb98mc9038p	5	31	-	-	PUNCT
qb98mc9038p	5	32	membered	membered	ADJ
qb98mc9038p	5	33	macrolide	macrolide	NOUN
qb98mc9038p	5	34	,	,	PUNCT
qb98mc9038p	5	35	isoapoptolidin	isoapoptolidin	PROPN
qb98mc9038p	5	36	.	.	PUNCT
qb98mc9038p	6	1	isoapoptolidin	isoapoptolidin	PROPN
qb98mc9038p	6	2	was	be	AUX
qb98mc9038p	6	3	found	find	VERB
qb98mc9038p	6	4	to	to	PART
qb98mc9038p	6	5	be	be	AUX
qb98mc9038p	6	6	considerably	considerably	ADV
qb98mc9038p	6	7	less	less	ADV
qb98mc9038p	6	8	active	active	ADJ
qb98mc9038p	6	9	than	than	ADP
qb98mc9038p	6	10	apoptolidin	apoptolidin	VERB
qb98mc9038p	6	11	calling	call	VERB
qb98mc9038p	6	12	into	into	ADP
qb98mc9038p	6	13	question	question	NOUN
qb98mc9038p	6	14	previous	previous	ADJ
qb98mc9038p	6	15	assay	assay	NOUN
qb98mc9038p	6	16	data	datum	NOUN
qb98mc9038p	6	17	.	.	PUNCT
qb98mc9038p	7	1	attempts	attempt	NOUN
qb98mc9038p	7	2	were	be	AUX
qb98mc9038p	7	3	made	make	VERB
qb98mc9038p	7	4	to	to	PART
qb98mc9038p	7	5	block	block	VERB
qb98mc9038p	7	6	this	this	DET
qb98mc9038p	7	7	acyl	acyl	NOUN
qb98mc9038p	7	8	-	-	PUNCT
qb98mc9038p	7	9	migration	migration	NOUN
qb98mc9038p	7	10	,	,	PUNCT
qb98mc9038p	7	11	but	but	CCONJ
qb98mc9038p	7	12	led	lead	VERB
qb98mc9038p	7	13	to	to	ADP
qb98mc9038p	7	14	a	a	DET
qb98mc9038p	7	15	loss	loss	NOUN
qb98mc9038p	7	16	in	in	ADP
qb98mc9038p	7	17	activity	activity	NOUN
qb98mc9038p	7	18	.	.	PUNCT
qb98mc9038p	8	1	our	our	PRON
qb98mc9038p	8	2	efforts	effort	NOUN
qb98mc9038p	8	3	have	have	AUX
qb98mc9038p	8	4	been	be	AUX
qb98mc9038p	8	5	focused	focus	VERB
qb98mc9038p	8	6	on	on	ADP
qb98mc9038p	8	7	synthesizing	synthesize	VERB
qb98mc9038p	8	8	the	the	DET
qb98mc9038p	8	9	20	20	NUM
qb98mc9038p	8	10	-	-	PUNCT
qb98mc9038p	8	11	deoxy	deoxy	ADJ
qb98mc9038p	8	12	analogue	analogue	NOUN
qb98mc9038p	8	13	of	of	ADP
qb98mc9038p	8	14	apoptolidinone	apoptolidinone	NOUN
qb98mc9038p	8	15	eliminating	eliminate	VERB
qb98mc9038p	8	16	the	the	DET
qb98mc9038p	8	17	acyl	acyl	NOUN
qb98mc9038p	8	18	-	-	PUNCT
qb98mc9038p	8	19	migration	migration	NOUN
qb98mc9038p	8	20	without	without	ADP
qb98mc9038p	8	21	adversely	adversely	ADV
qb98mc9038p	8	22	affecting	affect	VERB
qb98mc9038p	8	23	the	the	DET
qb98mc9038p	8	24	structural	structural	ADJ
qb98mc9038p	8	25	conformation	conformation	NOUN
qb98mc9038p	8	26	of	of	ADP
qb98mc9038p	8	27	20	20	NUM
qb98mc9038p	8	28	-	-	PUNCT
qb98mc9038p	8	29	deoxyapoptolidinone	deoxyapoptolidinone	NOUN
qb98mc9038p	8	30	.	.	PUNCT
qb98mc9038p	9	1	because	because	SCONJ
qb98mc9038p	9	2	of	of	ADP
qb98mc9038p	9	3	its	its	PRON
qb98mc9038p	9	4	complexity	complexity	NOUN
qb98mc9038p	9	5	,	,	PUNCT
qb98mc9038p	9	6	20	20	NUM
qb98mc9038p	9	7	-	-	PUNCT
qb98mc9038p	9	8	deoxyapoptolidinone	deoxyapoptolidinone	PROPN
qb98mc9038p	9	9	was	be	AUX
qb98mc9038p	9	10	partitioned	partition	VERB
qb98mc9038p	9	11	into	into	ADP
qb98mc9038p	9	12	three	three	NUM
qb98mc9038p	9	13	smaller	small	ADJ
qb98mc9038p	9	14	fragments	fragment	NOUN
qb98mc9038p	9	15	.	.	PUNCT
qb98mc9038p	10	1	fragment	fragment	PROPN
qb98mc9038p	10	2	a	a	PRON
qb98mc9038p	10	3	was	be	AUX
qb98mc9038p	10	4	rapidly	rapidly	ADV
qb98mc9038p	10	5	synthesized	synthesize	VERB
qb98mc9038p	10	6	through	through	ADP
qb98mc9038p	10	7	repetitive	repetitive	ADJ
qb98mc9038p	10	8	thionyl	thionyl	ADJ
qb98mc9038p	10	9	chloride	chloride	NOUN
qb98mc9038p	10	10	rearrangements	rearrangement	NOUN
qb98mc9038p	10	11	demonstrating	demonstrate	VERB
qb98mc9038p	10	12	its	its	PRON
qb98mc9038p	10	13	utility	utility	NOUN
qb98mc9038p	10	14	as	as	ADP
qb98mc9038p	10	15	an	an	DET
qb98mc9038p	10	16	alternative	alternative	NOUN
qb98mc9038p	10	17	to	to	ADP
qb98mc9038p	10	18	the	the	DET
qb98mc9038p	10	19	classic	classic	ADJ
qb98mc9038p	10	20	wittig	wittig	NOUN
qb98mc9038p	10	21	and	and	CCONJ
qb98mc9038p	10	22	horner	horner	PROPN
qb98mc9038p	10	23	-	-	PUNCT
qb98mc9038p	10	24	wadsworth	wadsworth	NOUN
qb98mc9038p	10	25	-	-	PUNCT
qb98mc9038p	10	26	emmons	emmon	NOUN
qb98mc9038p	10	27	protocol	protocol	NOUN
qb98mc9038p	10	28	widely	widely	ADV
qb98mc9038p	10	29	used	use	VERB
qb98mc9038p	10	30	.	.	PUNCT
qb98mc9038p	11	1	fragment	fragment	PROPN
qb98mc9038p	11	2	b	b	PROPN
qb98mc9038p	11	3	in	in	ADP
qb98mc9038p	11	4	its	its	PRON
qb98mc9038p	11	5	various	various	ADJ
qb98mc9038p	11	6	forms	form	NOUN
qb98mc9038p	11	7	was	be	AUX
qb98mc9038p	11	8	synthesized	synthesize	VERB
qb98mc9038p	11	9	from	from	ADP
qb98mc9038p	11	10	commercially	commercially	ADV
qb98mc9038p	11	11	available	available	ADJ
qb98mc9038p	11	12	(	(	PUNCT
qb98mc9038p	11	13	l)-malic	l)-malic	ADJ
qb98mc9038p	11	14	acid	acid	NOUN
qb98mc9038p	11	15	utilizing	utilize	VERB
qb98mc9038p	11	16	the	the	DET
qb98mc9038p	11	17	purchased	purchase	VERB
qb98mc9038p	11	18	stereochemistry	stereochemistry	NOUN
qb98mc9038p	11	19	to	to	PART
qb98mc9038p	11	20	influence	influence	VERB
qb98mc9038p	11	21	the	the	DET
qb98mc9038p	11	22	addition	addition	NOUN
qb98mc9038p	11	23	of	of	ADP
qb98mc9038p	11	24	several	several	ADJ
qb98mc9038p	11	25	new	new	ADJ
qb98mc9038p	11	26	stereocenters	stereocenter	NOUN
qb98mc9038p	11	27	.	.	PUNCT
qb98mc9038p	12	1	fragment	fragment	ADJ
qb98mc9038p	12	2	c	c	PROPN
qb98mc9038p	12	3	consisting	consist	VERB
qb98mc9038p	12	4	of	of	ADP
qb98mc9038p	12	5	several	several	ADJ
qb98mc9038p	12	6	propionate	propionate	NOUN
qb98mc9038p	12	7	units	unit	NOUN
qb98mc9038p	12	8	was	be	AUX
qb98mc9038p	12	9	constructed	construct	VERB
qb98mc9038p	12	10	via	via	ADP
qb98mc9038p	12	11	repetitive	repetitive	ADJ
qb98mc9038p	12	12	oxazolidinonethione	oxazolidinonethione	NOUN
qb98mc9038p	12	13	based	base	VERB
qb98mc9038p	12	14	aldol	aldol	PROPN
qb98mc9038p	12	15	condensations	condensation	NOUN
qb98mc9038p	12	16	achieving	achieve	VERB
qb98mc9038p	12	17	the	the	DET
qb98mc9038p	12	18	fragment	fragment	NOUN
qb98mc9038p	12	19	in	in	ADP
qb98mc9038p	12	20	an	an	DET
qb98mc9038p	12	21	efficient	efficient	ADJ
qb98mc9038p	12	22	and	and	CCONJ
qb98mc9038p	12	23	timely	timely	ADJ
qb98mc9038p	12	24	manner	manner	NOUN
qb98mc9038p	12	25	.	.	PUNCT
qb98mc9038p	13	1	once	once	ADV
qb98mc9038p	13	2	constructed	construct	VERB
qb98mc9038p	13	3	the	the	DET
qb98mc9038p	13	4	three	three	NUM
qb98mc9038p	13	5	fragments	fragment	NOUN
qb98mc9038p	13	6	are	be	AUX
qb98mc9038p	13	7	coupled	couple	VERB
qb98mc9038p	13	8	together	together	ADV
qb98mc9038p	13	9	through	through	ADP
qb98mc9038p	13	10	a	a	DET
qb98mc9038p	13	11	mukaiyama	mukaiyama	PROPN
qb98mc9038p	13	12	aldol	aldol	NOUN
qb98mc9038p	13	13	,	,	PUNCT
qb98mc9038p	13	14	stille	stille	NOUN
qb98mc9038p	13	15	coupling	coupling	NOUN
qb98mc9038p	13	16	and	and	CCONJ
qb98mc9038p	13	17	yamaguchi	yamaguchi	PROPN
qb98mc9038p	13	18	macrolactonization	macrolactonization	NOUN
qb98mc9038p	13	19	yielding	yield	VERB
qb98mc9038p	13	20	the	the	DET
qb98mc9038p	13	21	desired	desire	VERB
qb98mc9038p	13	22	20	20	NUM
qb98mc9038p	13	23	-	-	PUNCT
qb98mc9038p	13	24	deoxyapoptolidinone	deoxyapoptolidinone	NOUN
qb98mc9038p	13	25	.	.	PUNCT
qb98mc9038p	14	1	upon	upon	SCONJ
qb98mc9038p	14	2	completion	completion	NOUN
qb98mc9038p	14	3	,	,	PUNCT
qb98mc9038p	14	4	the	the	DET
qb98mc9038p	14	5	synthesis	synthesis	NOUN
qb98mc9038p	14	6	of	of	ADP
qb98mc9038p	14	7	20	20	NUM
qb98mc9038p	14	8	-	-	PUNCT
qb98mc9038p	14	9	deoxyapoptolidinone	deoxyapoptolidinone	PROPN
qb98mc9038p	14	10	will	will	AUX
qb98mc9038p	14	11	provide	provide	VERB
qb98mc9038p	14	12	the	the	DET
qb98mc9038p	14	13	framework	framework	NOUN
qb98mc9038p	14	14	for	for	ADP
qb98mc9038p	14	15	future	future	ADJ
qb98mc9038p	14	16	'	'	PUNCT
qb98mc9038p	14	17	chimeric	chimeric	ADJ
qb98mc9038p	14	18	'	'	PUNCT
qb98mc9038p	14	19	analogues	analogue	NOUN
qb98mc9038p	14	20	.	.	PUNCT
qb98mc9038p	15	1	these	these	DET
qb98mc9038p	15	2	'	'	PUNCT
qb98mc9038p	15	3	chimeric	chimeric	ADJ
qb98mc9038p	15	4	'	'	PUNCT
qb98mc9038p	15	5	analogues	analogue	NOUN
qb98mc9038p	15	6	will	will	AUX
qb98mc9038p	15	7	consist	consist	VERB
qb98mc9038p	15	8	of	of	ADP
qb98mc9038p	15	9	20	20	NUM
qb98mc9038p	15	10	-	-	PUNCT
qb98mc9038p	15	11	deoxyapoptolidin	deoxyapoptolidin	NOUN
qb98mc9038p	15	12	's	's	PART
qb98mc9038p	15	13	macrolide	macrolide	NOUN
qb98mc9038p	15	14	with	with	ADP
qb98mc9038p	15	15	the	the	DET
qb98mc9038p	15	16	pyran	pyran	PROPN
qb98mc9038p	15	17	portions	portion	NOUN
qb98mc9038p	15	18	of	of	ADP
qb98mc9038p	15	19	concanamycin	concanamycin	PROPN
qb98mc9038p	15	20	and	and	CCONJ
qb98mc9038p	15	21	bafilomycin	bafilomycin	PROPN
qb98mc9038p	15	22	in	in	ADP
qb98mc9038p	15	23	an	an	DET
qb98mc9038p	15	24	effort	effort	NOUN
qb98mc9038p	15	25	to	to	PART
qb98mc9038p	15	26	achieve	achieve	VERB
qb98mc9038p	15	27	cross	cross	NOUN
qb98mc9038p	15	28	affinity	affinity	NOUN
qb98mc9038p	15	29	for	for	ADP
qb98mc9038p	15	30	f0f1and	f0f1and	NUM
qb98mc9038p	15	31	v	v	NOUN
qb98mc9038p	15	32	-	-	PUNCT
qb98mc9038p	15	33	type	type	NOUN
qb98mc9038p	15	34	atpase	atpase	NOUN
qb98mc9038p	15	35	.	.	PUNCT