id sid tid token lemma pos q237hq4081v 1 1 atherosclerosis atherosclerosis NOUN q237hq4081v 1 2 is be AUX q237hq4081v 1 3 one one NUM q237hq4081v 1 4 of of ADP q237hq4081v 1 5 the the DET q237hq4081v 1 6 leading lead VERB q237hq4081v 1 7 causes cause NOUN q237hq4081v 1 8 of of ADP q237hq4081v 1 9 mortality mortality NOUN q237hq4081v 1 10 and and CCONJ q237hq4081v 1 11 morbidity morbidity NOUN q237hq4081v 1 12 in in ADP q237hq4081v 1 13 western western ADJ q237hq4081v 1 14 countries country NOUN q237hq4081v 1 15 and and CCONJ q237hq4081v 1 16 high high ADJ q237hq4081v 1 17 total total ADJ q237hq4081v 1 18 cholesterol cholesterol NOUN q237hq4081v 1 19 and and CCONJ q237hq4081v 1 20 high high ADJ q237hq4081v 1 21 low low ADJ q237hq4081v 1 22 - - PUNCT q237hq4081v 1 23 density density NOUN q237hq4081v 1 24 lipoprotein lipoprotein NOUN q237hq4081v 1 25 ( ( PUNCT q237hq4081v 1 26 ldl ldl NOUN q237hq4081v 1 27 ) ) PUNCT q237hq4081v 1 28 cholesterol cholesterol NOUN q237hq4081v 1 29 levels level NOUN q237hq4081v 1 30 are be AUX q237hq4081v 1 31 associated associate VERB q237hq4081v 1 32 with with ADP q237hq4081v 1 33 the the DET q237hq4081v 1 34 development development NOUN q237hq4081v 1 35 of of ADP q237hq4081v 1 36 atherosclerosis atherosclerosis NOUN q237hq4081v 1 37 . . PUNCT q237hq4081v 2 1 soy soy NOUN q237hq4081v 2 2 intake intake NOUN q237hq4081v 2 3 has have AUX q237hq4081v 2 4 been be AUX q237hq4081v 2 5 documented document VERB q237hq4081v 2 6 to to PART q237hq4081v 2 7 reduce reduce VERB q237hq4081v 2 8 the the DET q237hq4081v 2 9 risk risk NOUN q237hq4081v 2 10 of of ADP q237hq4081v 2 11 heart heart NOUN q237hq4081v 2 12 disease disease NOUN q237hq4081v 2 13 by by ADP q237hq4081v 2 14 lowering lower VERB q237hq4081v 2 15 blood blood NOUN q237hq4081v 2 16 cholesterol cholesterol NOUN q237hq4081v 2 17 levels level NOUN q237hq4081v 2 18 . . PUNCT q237hq4081v 3 1 isoflavone isoflavone NOUN q237hq4081v 3 2 - - PUNCT q237hq4081v 3 3 containing contain VERB q237hq4081v 3 4 soyfood soyfood NOUN q237hq4081v 3 5 products product NOUN q237hq4081v 3 6 and and CCONJ q237hq4081v 3 7 supplements supplement NOUN q237hq4081v 3 8 are be AUX q237hq4081v 3 9 commercially commercially ADV q237hq4081v 3 10 available available ADJ q237hq4081v 3 11 and and CCONJ q237hq4081v 3 12 promoted promote VERB q237hq4081v 3 13 to to PART q237hq4081v 3 14 treat treat VERB q237hq4081v 3 15 several several ADJ q237hq4081v 3 16 different different ADJ q237hq4081v 3 17 health health NOUN q237hq4081v 3 18 conditions condition NOUN q237hq4081v 3 19 including include VERB q237hq4081v 3 20 improving improve VERB q237hq4081v 3 21 blood blood NOUN q237hq4081v 3 22 lipid lipid NOUN q237hq4081v 3 23 profiles profile NOUN q237hq4081v 3 24 . . PUNCT q237hq4081v 4 1 the the DET q237hq4081v 4 2 transport transport NOUN q237hq4081v 4 3 and and CCONJ q237hq4081v 4 4 metabolism metabolism NOUN q237hq4081v 4 5 of of ADP q237hq4081v 4 6 most most ADJ q237hq4081v 4 7 xenobiotics xenobiotic NOUN q237hq4081v 4 8 are be AUX q237hq4081v 4 9 affected affect VERB q237hq4081v 4 10 by by ADP q237hq4081v 4 11 the the DET q237hq4081v 4 12 drug drug NOUN q237hq4081v 4 13 transporters transporter NOUN q237hq4081v 4 14 and and CCONJ q237hq4081v 4 15 metabolizing metabolize VERB q237hq4081v 4 16 enzymes enzyme NOUN q237hq4081v 4 17 in in ADP q237hq4081v 4 18 the the DET q237hq4081v 4 19 liver liver NOUN q237hq4081v 4 20 and and CCONJ q237hq4081v 4 21 small small ADJ q237hq4081v 4 22 intestine intestine NOUN q237hq4081v 4 23 and and CCONJ q237hq4081v 4 24 the the DET q237hq4081v 4 25 expression expression NOUN q237hq4081v 4 26 of of ADP q237hq4081v 4 27 these these DET q237hq4081v 4 28 genes gene NOUN q237hq4081v 4 29 affect affect VERB q237hq4081v 4 30 the the DET q237hq4081v 4 31 potency potency NOUN q237hq4081v 4 32 of of ADP q237hq4081v 4 33 drugs drug NOUN q237hq4081v 4 34 or or CCONJ q237hq4081v 4 35 xenobiotics xenobiotic NOUN q237hq4081v 4 36 . . PUNCT q237hq4081v 5 1 cytochrome cytochrome PROPN q237hq4081v 5 2 p450s p450s PROPN q237hq4081v 5 3 ( ( PUNCT q237hq4081v 5 4 cyps cyps PROPN q237hq4081v 5 5 ) ) PUNCT q237hq4081v 5 6 are be AUX q237hq4081v 5 7 important important ADJ q237hq4081v 5 8 phase phase NOUN q237hq4081v 5 9 i i PRON q237hq4081v 5 10 drug drug NOUN q237hq4081v 5 11 - - PUNCT q237hq4081v 5 12 metabolizing metabolize VERB q237hq4081v 5 13 enzymes enzyme NOUN q237hq4081v 5 14 in in ADP q237hq4081v 5 15 the the DET q237hq4081v 5 16 liver liver NOUN q237hq4081v 5 17 and and CCONJ q237hq4081v 5 18 the the DET q237hq4081v 5 19 expression expression NOUN q237hq4081v 5 20 levels level NOUN q237hq4081v 5 21 of of ADP q237hq4081v 5 22 cyp1 cyp1 PROPN q237hq4081v 5 23 , , PUNCT q237hq4081v 5 24 2 2 NUM q237hq4081v 5 25 , , PUNCT q237hq4081v 5 26 and and CCONJ q237hq4081v 5 27 3 3 NUM q237hq4081v 5 28 subfamilies subfamily NOUN q237hq4081v 5 29 are be AUX q237hq4081v 5 30 the the DET q237hq4081v 5 31 rate rate NOUN q237hq4081v 5 32 - - PUNCT q237hq4081v 5 33 limiting limit VERB q237hq4081v 5 34 factor factor NOUN q237hq4081v 5 35 for for ADP q237hq4081v 5 36 the the DET q237hq4081v 5 37 turnover turnover NOUN q237hq4081v 5 38 of of ADP q237hq4081v 5 39 many many ADJ q237hq4081v 5 40 drugs drug NOUN q237hq4081v 5 41 . . PUNCT q237hq4081v 6 1 the the DET q237hq4081v 6 2 cholesterol cholesterol NOUN q237hq4081v 6 3 - - PUNCT q237hq4081v 6 4 lowering lower VERB q237hq4081v 6 5 statins statin NOUN q237hq4081v 6 6 may may AUX q237hq4081v 6 7 be be AUX q237hq4081v 6 8 metabolized metabolize VERB q237hq4081v 6 9 by by ADP q237hq4081v 6 10 different different ADJ q237hq4081v 6 11 cyps cyps PROPN q237hq4081v 6 12 . . PUNCT q237hq4081v 7 1 among among ADP q237hq4081v 7 2 the the DET q237hq4081v 7 3 isoforms isoform NOUN q237hq4081v 7 4 , , PUNCT q237hq4081v 7 5 cyp3a4 cyp3a4 PROPN q237hq4081v 7 6 is be AUX q237hq4081v 7 7 responsible responsible ADJ q237hq4081v 7 8 for for ADP q237hq4081v 7 9 nearly nearly ADV q237hq4081v 7 10 54 54 NUM q237hq4081v 7 11 % % NOUN q237hq4081v 7 12 of of ADP q237hq4081v 7 13 all all DET q237hq4081v 7 14 drug drug NOUN q237hq4081v 7 15 - - PUNCT q237hq4081v 7 16 turnover turnover NOUN q237hq4081v 7 17 and and CCONJ q237hq4081v 7 18 is be AUX q237hq4081v 7 19 considered consider VERB q237hq4081v 7 20 most most ADV q237hq4081v 7 21 important important ADJ q237hq4081v 7 22 . . PUNCT q237hq4081v 8 1 there there PRON q237hq4081v 8 2 is be VERB q237hq4081v 8 3 evidence evidence NOUN q237hq4081v 8 4 showing show VERB q237hq4081v 8 5 that that SCONJ q237hq4081v 8 6 soy soy NOUN q237hq4081v 8 7 isoflavones isoflavone NOUN q237hq4081v 8 8 may may AUX q237hq4081v 8 9 affect affect VERB q237hq4081v 8 10 the the DET q237hq4081v 8 11 expression expression NOUN q237hq4081v 8 12 of of ADP q237hq4081v 8 13 some some PRON q237hq4081v 8 14 of of ADP q237hq4081v 8 15 the the DET q237hq4081v 8 16 genes gene NOUN q237hq4081v 8 17 in in ADP q237hq4081v 8 18 drug drug NOUN q237hq4081v 8 19 metabolism metabolism NOUN q237hq4081v 8 20 pathways pathway NOUN q237hq4081v 8 21 . . PUNCT q237hq4081v 9 1 my my PRON q237hq4081v 9 2 project project NOUN q237hq4081v 9 3 is be AUX q237hq4081v 9 4 focused focus VERB q237hq4081v 9 5 on on ADP q237hq4081v 9 6 the the DET q237hq4081v 9 7 effect effect NOUN q237hq4081v 9 8 of of ADP q237hq4081v 9 9 isoflavones isoflavone NOUN q237hq4081v 9 10 on on ADP q237hq4081v 9 11 cyp1a2 cyp1a2 PROPN q237hq4081v 9 12 , , PUNCT q237hq4081v 9 13 2c9 2c9 NUM q237hq4081v 9 14 , , PUNCT q237hq4081v 9 15 3a4 3a4 NUM q237hq4081v 9 16 , , PUNCT q237hq4081v 9 17 as as ADP q237hq4081v 9 18 model model NOUN q237hq4081v 9 19 isoforms isoform NOUN q237hq4081v 9 20 of of ADP q237hq4081v 9 21 cyps cyps PROPN q237hq4081v 9 22 , , PUNCT q237hq4081v 9 23 and and CCONJ q237hq4081v 9 24 the the DET q237hq4081v 9 25 identification identification NOUN q237hq4081v 9 26 of of ADP q237hq4081v 9 27 other other ADJ q237hq4081v 9 28 genes gene NOUN q237hq4081v 9 29 pertaining pertain VERB q237hq4081v 9 30 to to ADP q237hq4081v 9 31 drug drug NOUN q237hq4081v 9 32 transport transport NOUN q237hq4081v 9 33 and and CCONJ q237hq4081v 9 34 biotransformation biotransformation NOUN q237hq4081v 9 35 whose whose DET q237hq4081v 9 36 expression expression NOUN q237hq4081v 9 37 is be AUX q237hq4081v 9 38 affected affect VERB q237hq4081v 9 39 by by ADP q237hq4081v 9 40 isoflavones isoflavone NOUN q237hq4081v 9 41 . . PUNCT q237hq4081v 10 1 we we PRON q237hq4081v 10 2 have have AUX q237hq4081v 10 3 found find VERB q237hq4081v 10 4 that that SCONJ q237hq4081v 10 5 isoflavones isoflavone NOUN q237hq4081v 10 6 upregulate upregulate VERB q237hq4081v 10 7 cyp3a4 cyp3a4 NOUN q237hq4081v 10 8 expression expression NOUN q237hq4081v 10 9 ; ; PUNCT q237hq4081v 10 10 and and CCONJ q237hq4081v 10 11 equol equol PROPN q237hq4081v 10 12 , , PUNCT q237hq4081v 10 13 a a DET q237hq4081v 10 14 metabolite metabolite NOUN q237hq4081v 10 15 of of ADP q237hq4081v 10 16 daidzein daidzein NOUN q237hq4081v 10 17 , , PUNCT q237hq4081v 10 18 appears appear VERB q237hq4081v 10 19 to to PART q237hq4081v 10 20 be be AUX q237hq4081v 10 21 a a DET q237hq4081v 10 22 most most ADV q237hq4081v 10 23 potent potent ADJ q237hq4081v 10 24 inducer inducer NOUN q237hq4081v 10 25 of of ADP q237hq4081v 10 26 cyp3a4 cyp3a4 PROPN q237hq4081v 10 27 . . PUNCT q237hq4081v 11 1 similarly similarly ADV q237hq4081v 11 2 , , PUNCT q237hq4081v 11 3 isoflavones isoflavone NOUN q237hq4081v 11 4 also also ADV q237hq4081v 11 5 induce induce VERB q237hq4081v 11 6 the the DET q237hq4081v 11 7 expression expression NOUN q237hq4081v 11 8 of of ADP q237hq4081v 11 9 cyp1a2 cyp1a2 PROPN q237hq4081v 11 10 , , PUNCT q237hq4081v 11 11 but but CCONJ q237hq4081v 11 12 not not PART q237hq4081v 11 13 cyp2c9 cyp2c9 PROPN q237hq4081v 11 14 . . PUNCT q237hq4081v 12 1 using use VERB q237hq4081v 12 2 gene gene NOUN q237hq4081v 12 3 screening screening NOUN q237hq4081v 12 4 methods method NOUN q237hq4081v 12 5 , , PUNCT q237hq4081v 12 6 two two NUM q237hq4081v 12 7 drug drug NOUN q237hq4081v 12 8 transporters transporter NOUN q237hq4081v 12 9 , , PUNCT q237hq4081v 12 10 three three NUM q237hq4081v 12 11 phase phase NOUN q237hq4081v 12 12 i i PRON q237hq4081v 12 13 enzymes enzyme NOUN q237hq4081v 12 14 , , PUNCT q237hq4081v 12 15 and and CCONJ q237hq4081v 12 16 two two NUM q237hq4081v 12 17 phase phase NOUN q237hq4081v 12 18 ii ii NOUN q237hq4081v 12 19 enzymes enzyme NOUN q237hq4081v 12 20 were be AUX q237hq4081v 12 21 identified identify VERB q237hq4081v 12 22 to to PART q237hq4081v 12 23 be be AUX q237hq4081v 12 24 induced induce VERB q237hq4081v 12 25 by by ADP q237hq4081v 12 26 isoflavones isoflavone NOUN q237hq4081v 12 27 in in ADP q237hq4081v 12 28 human human ADJ q237hq4081v 12 29 hepatocytes hepatocyte NOUN q237hq4081v 12 30 exposed expose VERB q237hq4081v 12 31 to to ADP q237hq4081v 12 32 isoflavones isoflavone NOUN q237hq4081v 12 33 . . PUNCT q237hq4081v 13 1 cyp8b1 cyp8b1 PROPN q237hq4081v 13 2 , , PUNCT q237hq4081v 13 3 a a DET q237hq4081v 13 4 gene gene NOUN q237hq4081v 13 5 encoding encode VERB q237hq4081v 13 6 an an DET q237hq4081v 13 7 enzyme enzyme NOUN q237hq4081v 13 8 at at ADP q237hq4081v 13 9 a a DET q237hq4081v 13 10 branch branch NOUN q237hq4081v 13 11 point point NOUN q237hq4081v 13 12 in in ADP q237hq4081v 13 13 the the DET q237hq4081v 13 14 bile bile NOUN q237hq4081v 13 15 acid acid NOUN q237hq4081v 13 16 synthesis synthesis NOUN q237hq4081v 13 17 pathway pathway NOUN q237hq4081v 13 18 appears appear VERB q237hq4081v 13 19 to to PART q237hq4081v 13 20 be be AUX q237hq4081v 13 21 an an DET q237hq4081v 13 22 important important ADJ q237hq4081v 13 23 target target NOUN q237hq4081v 13 24 gene gene NOUN q237hq4081v 13 25 activated activate VERB q237hq4081v 13 26 by by ADP q237hq4081v 13 27 isoflavones isoflavone NOUN q237hq4081v 13 28 . . PUNCT q237hq4081v 14 1 furthermore furthermore ADV q237hq4081v 14 2 , , PUNCT q237hq4081v 14 3 an an DET q237hq4081v 14 4 interaction interaction NOUN q237hq4081v 14 5 between between ADP q237hq4081v 14 6 isoflavones isoflavone NOUN q237hq4081v 14 7 and and CCONJ q237hq4081v 14 8 statins statin NOUN q237hq4081v 14 9 appears appear VERB q237hq4081v 14 10 to to PART q237hq4081v 14 11 affect affect VERB q237hq4081v 14 12 cyp3a4 cyp3a4 NOUN q237hq4081v 14 13 gene gene NOUN q237hq4081v 14 14 transcription transcription NOUN q237hq4081v 14 15 and and CCONJ q237hq4081v 14 16 cellular cellular ADJ q237hq4081v 14 17 lipid lipid NOUN q237hq4081v 14 18 metabolism metabolism NOUN q237hq4081v 14 19 . . PUNCT q237hq4081v 15 1 taken take VERB q237hq4081v 15 2 together together ADV q237hq4081v 15 3 , , PUNCT q237hq4081v 15 4 the the DET q237hq4081v 15 5 isoflavones isoflavone NOUN q237hq4081v 15 6 are be AUX q237hq4081v 15 7 able able ADJ q237hq4081v 15 8 to to PART q237hq4081v 15 9 affect affect VERB q237hq4081v 15 10 the the DET q237hq4081v 15 11 complex complex ADJ q237hq4081v 15 12 drug drug NOUN q237hq4081v 15 13 metabolism metabolism NOUN q237hq4081v 15 14 pathways pathway NOUN q237hq4081v 15 15 and and CCONJ q237hq4081v 15 16 these these DET q237hq4081v 15 17 in in ADV q237hq4081v 15 18 - - PUNCT q237hq4081v 15 19 vitro vitro X q237hq4081v 15 20 interactions interaction NOUN q237hq4081v 15 21 of of ADP q237hq4081v 15 22 isoflavones isoflavone NOUN q237hq4081v 15 23 with with ADP q237hq4081v 15 24 statins statin NOUN q237hq4081v 15 25 suggest suggest VERB q237hq4081v 15 26 clinical clinical ADJ q237hq4081v 15 27 studies study NOUN q237hq4081v 15 28 are be AUX q237hq4081v 15 29 warranted warrant VERB q237hq4081v 15 30 . . PUNCT