id sid tid token lemma pos pz50gt5705c 1 1 understanding understand VERB pz50gt5705c 1 2 how how SCONJ pz50gt5705c 1 3 a a DET pz50gt5705c 1 4 polypeptide polypeptide NOUN pz50gt5705c 1 5 chain chain NOUN pz50gt5705c 1 6 achieves achieve VERB pz50gt5705c 1 7 its its PRON pz50gt5705c 1 8 native native ADJ pz50gt5705c 1 9 fold fold NOUN pz50gt5705c 1 10 and and CCONJ pz50gt5705c 1 11 the the DET pz50gt5705c 1 12 complex complex ADJ pz50gt5705c 1 13 interplay interplay NOUN pz50gt5705c 1 14 between between ADP pz50gt5705c 1 15 folding folding NOUN pz50gt5705c 1 16 and and CCONJ pz50gt5705c 1 17 aggregation aggregation NOUN pz50gt5705c 1 18 remains remain VERB pz50gt5705c 1 19 , , PUNCT pz50gt5705c 1 20 even even ADV pz50gt5705c 1 21 after after ADP pz50gt5705c 1 22 over over ADP pz50gt5705c 1 23 40 40 NUM pz50gt5705c 1 24 years year NOUN pz50gt5705c 1 25 , , PUNCT pz50gt5705c 1 26 an an DET pz50gt5705c 1 27 area area NOUN pz50gt5705c 1 28 of of ADP pz50gt5705c 1 29 active active ADJ pz50gt5705c 1 30 research research NOUN pz50gt5705c 1 31 . . PUNCT pz50gt5705c 2 1 particularly particularly ADV pz50gt5705c 2 2 , , PUNCT pz50gt5705c 2 3 understanding understand VERB pz50gt5705c 2 4 how how SCONJ pz50gt5705c 2 5 large large ADJ pz50gt5705c 2 6 , , PUNCT pz50gt5705c 2 7 topologically topologically ADV pz50gt5705c 2 8 complex complex ADJ pz50gt5705c 2 9 proteins protein NOUN pz50gt5705c 2 10 fold fold VERB pz50gt5705c 2 11 and and CCONJ pz50gt5705c 2 12 avoid avoid VERB pz50gt5705c 2 13 aggregation aggregation NOUN pz50gt5705c 2 14 is be AUX pz50gt5705c 2 15 crucial crucial ADJ pz50gt5705c 2 16 for for ADP pz50gt5705c 2 17 the the DET pz50gt5705c 2 18 advancement advancement NOUN pz50gt5705c 2 19 of of ADP pz50gt5705c 2 20 the the DET pz50gt5705c 2 21 field field NOUN pz50gt5705c 2 22 . . PUNCT pz50gt5705c 3 1 this this DET pz50gt5705c 3 2 thesis thesis NOUN pz50gt5705c 3 3 specifically specifically ADV pz50gt5705c 3 4 investigates investigate VERB pz50gt5705c 3 5 the the DET pz50gt5705c 3 6 relationship relationship NOUN pz50gt5705c 3 7 between between ADP pz50gt5705c 3 8 folding folding NOUN pz50gt5705c 3 9 and and CCONJ pz50gt5705c 3 10 aggregation aggregation NOUN pz50gt5705c 3 11 of of ADP pz50gt5705c 3 12 large large ADJ pz50gt5705c 3 13 , , PUNCT pz50gt5705c 3 14 & & CCONJ pz50gt5705c 3 15 # # SYM pz50gt5705c 3 16 946;-sheet 946;-sheet NUM pz50gt5705c 3 17 rich rich ADJ pz50gt5705c 3 18 proteins protein NOUN pz50gt5705c 3 19 with with ADP pz50gt5705c 3 20 complex complex ADJ pz50gt5705c 3 21 folding fold VERB pz50gt5705c 3 22 mechanisms mechanism NOUN pz50gt5705c 3 23 with with ADP pz50gt5705c 3 24 an an DET pz50gt5705c 3 25 emphasis emphasis NOUN pz50gt5705c 3 26 on on ADP pz50gt5705c 3 27 & & CCONJ pz50gt5705c 3 28 # # SYM pz50gt5705c 3 29 946;-helical 946;-helical ADJ pz50gt5705c 3 30 proteins protein NOUN pz50gt5705c 3 31 such such ADJ pz50gt5705c 3 32 as as ADP pz50gt5705c 3 33 pertactin pertactin NOUN pz50gt5705c 3 34 . . PUNCT pz50gt5705c 4 1 while while SCONJ pz50gt5705c 4 2 & & CCONJ pz50gt5705c 4 3 # # SYM pz50gt5705c 4 4 946;-sheet 946;-sheet NUM pz50gt5705c 4 5 rich rich ADJ pz50gt5705c 4 6 proteins protein NOUN pz50gt5705c 4 7 tend tend VERB pz50gt5705c 4 8 to to PART pz50gt5705c 4 9 have have VERB pz50gt5705c 4 10 slower slow ADJ pz50gt5705c 4 11 folding fold VERB pz50gt5705c 4 12 kinetics kinetic NOUN pz50gt5705c 4 13 and and CCONJ pz50gt5705c 4 14 increased increase VERB pz50gt5705c 4 15 population population NOUN pz50gt5705c 4 16 of of ADP pz50gt5705c 4 17 aggregation aggregation NOUN pz50gt5705c 4 18 prone prone ADJ pz50gt5705c 4 19 intermediates intermediate NOUN pz50gt5705c 4 20 ( ( PUNCT pz50gt5705c 4 21 1 1 NUM pz50gt5705c 4 22 , , PUNCT pz50gt5705c 4 23 2 2 NUM pz50gt5705c 4 24 ) ) PUNCT pz50gt5705c 4 25 , , PUNCT pz50gt5705c 4 26 & & CCONJ pz50gt5705c 4 27 # # SYM pz50gt5705c 4 28 946;-sheet 946;-sheet NUM pz50gt5705c 4 29 rich rich ADJ pz50gt5705c 4 30 proteins protein NOUN pz50gt5705c 4 31 can can AUX pz50gt5705c 4 32 avoid avoid VERB pz50gt5705c 4 33 aggregation aggregation NOUN pz50gt5705c 4 34 and and CCONJ pz50gt5705c 4 35 robustly robustly ADV pz50gt5705c 4 36 fold fold ADJ pz50gt5705c 4 37 ( ( PUNCT pz50gt5705c 4 38 3 3 NUM pz50gt5705c 4 39 ) ) PUNCT pz50gt5705c 4 40 . . PUNCT pz50gt5705c 5 1 specifically specifically ADV pz50gt5705c 5 2 , , PUNCT pz50gt5705c 5 3 & & CCONJ pz50gt5705c 5 4 # # SYM pz50gt5705c 5 5 946;-helical 946;-helical ADJ pz50gt5705c 5 6 proteins protein NOUN pz50gt5705c 5 7 possess possess VERB pz50gt5705c 5 8 structural structural ADJ pz50gt5705c 5 9 caps cap NOUN pz50gt5705c 5 10 that that PRON pz50gt5705c 5 11 prevent prevent VERB pz50gt5705c 5 12 aggregation aggregation NOUN pz50gt5705c 5 13 that that PRON pz50gt5705c 5 14 can can AUX pz50gt5705c 5 15 be be AUX pz50gt5705c 5 16 identified identify VERB pz50gt5705c 5 17 by by ADP pz50gt5705c 5 18 our our PRON pz50gt5705c 5 19 structure structure NOUN pz50gt5705c 5 20 - - PUNCT pz50gt5705c 5 21 based base VERB pz50gt5705c 5 22 prediction prediction NOUN pz50gt5705c 5 23 program program NOUN pz50gt5705c 5 24 , , PUNCT pz50gt5705c 5 25 helixcap helixcap ADV pz50gt5705c 5 26 ( ( PUNCT pz50gt5705c 5 27 4 4 NUM pz50gt5705c 5 28 ) ) PUNCT pz50gt5705c 5 29 . . PUNCT pz50gt5705c 6 1 additionally additionally ADV pz50gt5705c 6 2 , , PUNCT pz50gt5705c 6 3 aggregation aggregation NOUN pz50gt5705c 6 4 is be AUX pz50gt5705c 6 5 often often ADV pz50gt5705c 6 6 viewed view VERB pz50gt5705c 6 7 as as ADP pz50gt5705c 6 8 an an DET pz50gt5705c 6 9 irreversible irreversible ADJ pz50gt5705c 6 10 fate fate NOUN pz50gt5705c 6 11 for for ADP pz50gt5705c 6 12 folding fold VERB pz50gt5705c 6 13 polypeptides polypeptide NOUN pz50gt5705c 6 14 , , PUNCT pz50gt5705c 6 15 yet yet ADV pz50gt5705c 6 16 as as SCONJ pz50gt5705c 6 17 demonstrated demonstrate VERB pz50gt5705c 6 18 by by ADP pz50gt5705c 6 19 this this DET pz50gt5705c 6 20 work work NOUN pz50gt5705c 6 21 , , PUNCT pz50gt5705c 6 22 it it PRON pz50gt5705c 6 23 can can AUX pz50gt5705c 6 24 be be AUX pz50gt5705c 6 25 a a DET pz50gt5705c 6 26 dynamic dynamic ADJ pz50gt5705c 6 27 process process NOUN pz50gt5705c 6 28 . . PUNCT pz50gt5705c 7 1 during during ADP pz50gt5705c 7 2 refolding refolding NOUN pz50gt5705c 7 3 , , PUNCT pz50gt5705c 7 4 pertactin pertactin ADJ pz50gt5705c 7 5 forms form NOUN pz50gt5705c 7 6 loose loose ADJ pz50gt5705c 7 7 , , PUNCT pz50gt5705c 7 8 unstructured unstructured ADJ pz50gt5705c 7 9 transient transient ADJ pz50gt5705c 7 10 insoluble insoluble ADJ pz50gt5705c 7 11 aggregates aggregate NOUN pz50gt5705c 7 12 ( ( PUNCT pz50gt5705c 7 13 tia tia PROPN pz50gt5705c 7 14 ) ) PUNCT pz50gt5705c 7 15 that that PRON pz50gt5705c 7 16 disassemble disassemble VERB pz50gt5705c 7 17 without without ADP pz50gt5705c 7 18 the the DET pz50gt5705c 7 19 aid aid NOUN pz50gt5705c 7 20 of of ADP pz50gt5705c 7 21 molecular molecular ADJ pz50gt5705c 7 22 chaperones chaperone NOUN pz50gt5705c 7 23 to to PART pz50gt5705c 7 24 productively productively ADV pz50gt5705c 7 25 fold fold VERB pz50gt5705c 7 26 to to ADP pz50gt5705c 7 27 the the DET pz50gt5705c 7 28 native native ADJ pz50gt5705c 7 29 state state NOUN pz50gt5705c 7 30 . . PUNCT pz50gt5705c 8 1 understanding understand VERB pz50gt5705c 8 2 how how SCONJ pz50gt5705c 8 3 proteins protein NOUN pz50gt5705c 8 4 assemble assemble VERB pz50gt5705c 8 5 into into ADP pz50gt5705c 8 6 aggregate aggregate ADJ pz50gt5705c 8 7 structures structure NOUN pz50gt5705c 8 8 , , PUNCT pz50gt5705c 8 9 such such ADJ pz50gt5705c 8 10 as as ADP pz50gt5705c 8 11 the the DET pz50gt5705c 8 12 unstructured unstructured ADJ pz50gt5705c 8 13 tia tia PROPN pz50gt5705c 8 14 or or CCONJ pz50gt5705c 8 15 the the DET pz50gt5705c 8 16 large large ADJ pz50gt5705c 8 17 rope rope NOUN pz50gt5705c 8 18 - - PUNCT pz50gt5705c 8 19 like like ADJ pz50gt5705c 8 20 fibril fibril ADJ pz50gt5705c 8 21 aggregates aggregate NOUN pz50gt5705c 8 22 ( ( PUNCT pz50gt5705c 8 23 5 5 NUM pz50gt5705c 8 24 ) ) PUNCT pz50gt5705c 8 25 described describe VERB pz50gt5705c 8 26 in in ADP pz50gt5705c 8 27 this this DET pz50gt5705c 8 28 thesis thesis NOUN pz50gt5705c 8 29 , , PUNCT pz50gt5705c 8 30 can can AUX pz50gt5705c 8 31 lead lead VERB pz50gt5705c 8 32 to to ADP pz50gt5705c 8 33 controlled control VERB pz50gt5705c 8 34 assembly assembly NOUN pz50gt5705c 8 35 for for ADP pz50gt5705c 8 36 biomaterials biomaterial NOUN pz50gt5705c 8 37 applications application NOUN pz50gt5705c 8 38 and/or and/or CCONJ pz50gt5705c 8 39 prevention prevention NOUN pz50gt5705c 8 40 of of ADP pz50gt5705c 8 41 unwanted unwanted ADJ pz50gt5705c 8 42 aggregation aggregation NOUN pz50gt5705c 8 43 . . PUNCT