id	sid	tid	token	lemma	pos
pr76f190d5t	1	1	t	t	PROPN
pr76f190d5t	1	2	-	-	PUNCT
pr76f190d5t	1	3	cell	cell	NOUN
pr76f190d5t	1	4	receptors	receptor	NOUN
pr76f190d5t	1	5	(	(	PUNCT
pr76f190d5t	1	6	tcrs	tcrs	PROPN
pr76f190d5t	1	7	)	)	PUNCT
pr76f190d5t	1	8	are	be	AUX
pr76f190d5t	1	9	clonotypic	clonotypic	ADJ
pr76f190d5t	1	10	,	,	PUNCT
pr76f190d5t	1	11	heterodimeric	heterodimeric	ADJ
pr76f190d5t	1	12	receptors	receptor	NOUN
pr76f190d5t	1	13	on	on	ADP
pr76f190d5t	1	14	the	the	DET
pr76f190d5t	1	15	surface	surface	NOUN
pr76f190d5t	1	16	of	of	ADP
pr76f190d5t	1	17	t	t	NOUN
pr76f190d5t	1	18	-	-	PUNCT
pr76f190d5t	1	19	cells	cell	NOUN
pr76f190d5t	1	20	which	which	PRON
pr76f190d5t	1	21	possess	possess	VERB
pr76f190d5t	1	22	complementarity	complementarity	NOUN
pr76f190d5t	1	23	determining	determining	NOUN
pr76f190d5t	1	24	region	region	NOUN
pr76f190d5t	1	25	(	(	PUNCT
pr76f190d5t	1	26	cdr	cdr	NOUN
pr76f190d5t	1	27	)	)	PUNCT
pr76f190d5t	1	28	loops	loop	NOUN
pr76f190d5t	1	29	similar	similar	ADJ
pr76f190d5t	1	30	to	to	ADP
pr76f190d5t	1	31	immunoglobulins	immunoglobulin	NOUN
pr76f190d5t	1	32	.	.	PUNCT
pr76f190d5t	2	1	their	their	PRON
pr76f190d5t	2	2	function	function	NOUN
pr76f190d5t	2	3	is	be	AUX
pr76f190d5t	2	4	to	to	PART
pr76f190d5t	2	5	interact	interact	VERB
pr76f190d5t	2	6	with	with	ADP
pr76f190d5t	2	7	peptides	peptide	NOUN
pr76f190d5t	2	8	presented	present	VERB
pr76f190d5t	2	9	on	on	ADP
pr76f190d5t	2	10	major	major	ADJ
pr76f190d5t	2	11	-	-	PUNCT
pr76f190d5t	2	12	histocompatiblity	histocompatiblity	NOUN
pr76f190d5t	2	13	complexes	complex	NOUN
pr76f190d5t	2	14	(	(	PUNCT
pr76f190d5t	2	15	mhcs	mhcs	PROPN
pr76f190d5t	2	16	)	)	PUNCT
pr76f190d5t	2	17	on	on	ADP
pr76f190d5t	2	18	the	the	DET
pr76f190d5t	2	19	surface	surface	NOUN
pr76f190d5t	2	20	of	of	ADP
pr76f190d5t	2	21	most	most	ADJ
pr76f190d5t	2	22	nucleated	nucleated	ADJ
pr76f190d5t	2	23	cells	cell	NOUN
pr76f190d5t	2	24	.	.	PUNCT
pr76f190d5t	3	1	the	the	DET
pr76f190d5t	3	2	tcr	tcr	NOUN
pr76f190d5t	3	3	of	of	ADP
pr76f190d5t	3	4	a	a	DET
pr76f190d5t	3	5	circulated	circulate	VERB
pr76f190d5t	3	6	t	t	PROPN
pr76f190d5t	3	7	-	-	PUNCT
pr76f190d5t	3	8	cell	cell	NOUN
pr76f190d5t	3	9	(	(	PUNCT
pr76f190d5t	3	10	one	one	NUM
pr76f190d5t	3	11	which	which	PRON
pr76f190d5t	3	12	has	have	AUX
pr76f190d5t	3	13	undergone	undergo	VERB
pr76f190d5t	3	14	selection	selection	NOUN
pr76f190d5t	3	15	in	in	ADP
pr76f190d5t	3	16	the	the	DET
pr76f190d5t	3	17	thymus	thymus	NOUN
pr76f190d5t	3	18	)	)	PUNCT
pr76f190d5t	3	19	binds	bind	VERB
pr76f190d5t	3	20	to	to	ADP
pr76f190d5t	3	21	an	an	DET
pr76f190d5t	3	22	mhc	mhc	NOUN
pr76f190d5t	3	23	presenting	present	VERB
pr76f190d5t	3	24	a	a	DET
pr76f190d5t	3	25	'	'	PUNCT
pr76f190d5t	3	26	non	non	ADJ
pr76f190d5t	3	27	-	-	ADJ
pr76f190d5t	3	28	self	self	ADJ
pr76f190d5t	3	29	'	'	PUNCT
pr76f190d5t	3	30	peptide	peptide	NOUN
pr76f190d5t	3	31	with	with	ADP
pr76f190d5t	3	32	a	a	DET
pr76f190d5t	3	33	stronger	strong	ADJ
pr76f190d5t	3	34	affinity	affinity	NOUN
pr76f190d5t	3	35	than	than	SCONJ
pr76f190d5t	3	36	mhcs	mhc	NOUN
pr76f190d5t	3	37	presenting	present	VERB
pr76f190d5t	3	38	'	'	PUNCT
pr76f190d5t	3	39	self	self	NOUN
pr76f190d5t	3	40	'	'	PUNCT
pr76f190d5t	3	41	peptides	peptide	NOUN
pr76f190d5t	3	42	.	.	PUNCT
pr76f190d5t	4	1	the	the	DET
pr76f190d5t	4	2	tcr	tcr	NOUN
pr76f190d5t	4	3	must	must	AUX
pr76f190d5t	4	4	be	be	AUX
pr76f190d5t	4	5	able	able	ADJ
pr76f190d5t	4	6	to	to	PART
pr76f190d5t	4	7	distinguish	distinguish	VERB
pr76f190d5t	4	8	between	between	ADP
pr76f190d5t	4	9	these	these	DET
pr76f190d5t	4	10	two	two	NUM
pr76f190d5t	4	11	cases	case	NOUN
pr76f190d5t	4	12	despite	despite	SCONJ
pr76f190d5t	4	13	the	the	DET
pr76f190d5t	4	14	fact	fact	NOUN
pr76f190d5t	4	15	that	that	SCONJ
pr76f190d5t	4	16	the	the	DET
pr76f190d5t	4	17	majority	majority	NOUN
pr76f190d5t	4	18	of	of	ADP
pr76f190d5t	4	19	the	the	DET
pr76f190d5t	4	20	potential	potential	ADJ
pr76f190d5t	4	21	interface	interface	NOUN
pr76f190d5t	4	22	is	be	AUX
pr76f190d5t	4	23	conserved	conserve	VERB
pr76f190d5t	4	24	between	between	ADP
pr76f190d5t	4	25	the	the	DET
pr76f190d5t	4	26	two	two	NUM
pr76f190d5t	4	27	.	.	PUNCT
pr76f190d5t	5	1	to	to	PART
pr76f190d5t	5	2	assess	assess	VERB
pr76f190d5t	5	3	to	to	ADP
pr76f190d5t	5	4	what	what	DET
pr76f190d5t	5	5	extent	extent	NOUN
pr76f190d5t	5	6	the	the	DET
pr76f190d5t	5	7	different	different	ADJ
pr76f190d5t	5	8	portions	portion	NOUN
pr76f190d5t	5	9	of	of	ADP
pr76f190d5t	5	10	the	the	DET
pr76f190d5t	5	11	tcr	tcr	PROPN
pr76f190d5t	5	12	-	-	PUNCT
pr76f190d5t	5	13	pmhc	pmhc	PROPN
pr76f190d5t	5	14	interface	interface	NOUN
pr76f190d5t	5	15	contribute	contribute	VERB
pr76f190d5t	5	16	to	to	ADP
pr76f190d5t	5	17	binding	binding	PROPN
pr76f190d5t	5	18	,	,	PUNCT
pr76f190d5t	5	19	we	we	PRON
pr76f190d5t	5	20	quantify	quantify	VERB
pr76f190d5t	5	21	the	the	DET
pr76f190d5t	5	22	contributions	contribution	NOUN
pr76f190d5t	5	23	to	to	ADP
pr76f190d5t	5	24	binding	bind	VERB
pr76f190d5t	5	25	of	of	ADP
pr76f190d5t	5	26	the	the	DET
pr76f190d5t	5	27	side	side	NOUN
pr76f190d5t	5	28	-	-	PUNCT
pr76f190d5t	5	29	chain	chain	NOUN
pr76f190d5t	5	30	contacts	contact	NOUN
pr76f190d5t	5	31	between	between	ADP
pr76f190d5t	5	32	the	the	DET
pr76f190d5t	5	33	residues	residue	NOUN
pr76f190d5t	5	34	at	at	ADP
pr76f190d5t	5	35	the	the	DET
pr76f190d5t	5	36	interface	interface	NOUN
pr76f190d5t	5	37	through	through	ADP
pr76f190d5t	5	38	double	double	ADJ
pr76f190d5t	5	39	-	-	PUNCT
pr76f190d5t	5	40	mutant	mutant	ADJ
pr76f190d5t	5	41	cycles	cycle	NOUN
pr76f190d5t	5	42	.	.	PUNCT
pr76f190d5t	6	1	in	in	ADP
pr76f190d5t	6	2	a	a	DET
pr76f190d5t	6	3	double	double	ADJ
pr76f190d5t	6	4	mutant	mutant	ADJ
pr76f190d5t	6	5	cycle	cycle	NOUN
pr76f190d5t	6	6	between	between	ADP
pr76f190d5t	6	7	two	two	NUM
pr76f190d5t	6	8	residues	residue	NOUN
pr76f190d5t	6	9	,	,	PUNCT
pr76f190d5t	6	10	binding	bind	VERB
pr76f190d5t	6	11	experiments	experiment	NOUN
pr76f190d5t	6	12	are	be	AUX
pr76f190d5t	6	13	performed	perform	VERB
pr76f190d5t	6	14	between	between	ADP
pr76f190d5t	6	15	i	i	PROPN
pr76f190d5t	6	16	)	)	PUNCT
pr76f190d5t	6	17	the	the	DET
pr76f190d5t	6	18	native	native	ADJ
pr76f190d5t	6	19	partners	partner	NOUN
pr76f190d5t	6	20	,	,	PUNCT
pr76f190d5t	6	21	ii	ii	PROPN
pr76f190d5t	6	22	)	)	PUNCT
pr76f190d5t	6	23	the	the	DET
pr76f190d5t	6	24	two	two	NUM
pr76f190d5t	6	25	partners	partner	NOUN
pr76f190d5t	6	26	with	with	ADP
pr76f190d5t	6	27	one	one	NUM
pr76f190d5t	6	28	residue	residue	NOUN
pr76f190d5t	6	29	mutated	mutate	VERB
pr76f190d5t	6	30	to	to	ADP
pr76f190d5t	6	31	alanine	alanine	NOUN
pr76f190d5t	6	32	,	,	PUNCT
pr76f190d5t	6	33	iii	iii	PROPN
pr76f190d5t	6	34	)	)	PUNCT
pr76f190d5t	6	35	the	the	DET
pr76f190d5t	6	36	two	two	NUM
pr76f190d5t	6	37	partners	partner	NOUN
pr76f190d5t	6	38	with	with	ADP
pr76f190d5t	6	39	the	the	DET
pr76f190d5t	6	40	other	other	ADJ
pr76f190d5t	6	41	residue	residue	NOUN
pr76f190d5t	6	42	mutated	mutate	VERB
pr76f190d5t	6	43	to	to	ADP
pr76f190d5t	6	44	alanine	alanine	NOUN
pr76f190d5t	6	45	and	and	CCONJ
pr76f190d5t	6	46	iv	iv	X
pr76f190d5t	6	47	)	)	PUNCT
pr76f190d5t	6	48	the	the	DET
pr76f190d5t	6	49	two	two	NUM
pr76f190d5t	6	50	partners	partner	NOUN
pr76f190d5t	6	51	with	with	ADP
pr76f190d5t	6	52	both	both	DET
pr76f190d5t	6	53	residues	residue	NOUN
pr76f190d5t	6	54	mutated	mutate	VERB
pr76f190d5t	6	55	to	to	ADP
pr76f190d5t	6	56	alanine	alanine	NOUN
pr76f190d5t	6	57	.	.	PUNCT
pr76f190d5t	7	1	the	the	DET
pr76f190d5t	7	2	interaction	interaction	NOUN
pr76f190d5t	7	3	energy	energy	NOUN
pr76f190d5t	7	4	between	between	ADP
pr76f190d5t	7	5	those	those	DET
pr76f190d5t	7	6	two	two	NUM
pr76f190d5t	7	7	residues	residue	NOUN
pr76f190d5t	7	8	is	be	AUX
pr76f190d5t	7	9	defined	define	VERB
pr76f190d5t	7	10	as	as	ADP
pr76f190d5t	7	11	native	native	ADJ
pr76f190d5t	7	12	free	free	ADJ
pr76f190d5t	7	13	energy	energy	NOUN
pr76f190d5t	7	14	change	change	NOUN
pr76f190d5t	7	15	minus	minus	CCONJ
pr76f190d5t	7	16	the	the	DET
pr76f190d5t	7	17	free	free	ADJ
pr76f190d5t	7	18	energy	energy	NOUN
pr76f190d5t	7	19	changes	change	NOUN
pr76f190d5t	7	20	of	of	ADP
pr76f190d5t	7	21	the	the	DET
pr76f190d5t	7	22	two	two	NUM
pr76f190d5t	7	23	single	single	ADJ
pr76f190d5t	7	24	mutants	mutant	NOUN
pr76f190d5t	7	25	,	,	PUNCT
pr76f190d5t	7	26	plus	plus	CCONJ
pr76f190d5t	7	27	the	the	DET
pr76f190d5t	7	28	free	free	ADJ
pr76f190d5t	7	29	energy	energy	NOUN
pr76f190d5t	7	30	change	change	NOUN
pr76f190d5t	7	31	of	of	ADP
pr76f190d5t	7	32	the	the	DET
pr76f190d5t	7	33	double	double	ADJ
pr76f190d5t	7	34	-	-	PUNCT
pr76f190d5t	7	35	mutant	mutant	NOUN
pr76f190d5t	7	36	;	;	PUNCT
pr76f190d5t	7	37	ddgint	ddgint	NOUN
pr76f190d5t	7	38	=	=	SYM
pr76f190d5t	7	39	dg(xwt	dg(xwt	NOUN
pr76f190d5t	7	40	-	-	PUNCT
pr76f190d5t	7	41	ywt	ywt	NOUN
pr76f190d5t	7	42	)	)	PUNCT
pr76f190d5t	7	43	dg(xz->a	dg(xz->a	PROPN
pr76f190d5t	7	44	,	,	PUNCT
pr76f190d5t	7	45	ywt	ywt	NOUN
pr76f190d5t	7	46	)	)	PUNCT
pr76f190d5t	7	47	dg(xwt	dg(xwt	X
pr76f190d5t	7	48	,	,	PUNCT
pr76f190d5t	7	49	yz->a	yz->a	NOUN
pr76f190d5t	7	50	)	)	PUNCT
pr76f190d5t	7	51	+	+	CCONJ
pr76f190d5t	7	52	dg(xz->a	dg(xz->a	ADV
pr76f190d5t	7	53	,	,	PUNCT
pr76f190d5t	7	54	yz->a	yz->a	NOUN
pr76f190d5t	7	55	)	)	PUNCT
pr76f190d5t	7	56	.	.	PUNCT
pr76f190d5t	8	1	by	by	ADP
pr76f190d5t	8	2	comparing	compare	VERB
pr76f190d5t	8	3	the	the	DET
pr76f190d5t	8	4	interaction	interaction	NOUN
pr76f190d5t	8	5	energies	energy	NOUN
pr76f190d5t	8	6	of	of	ADP
pr76f190d5t	8	7	the	the	DET
pr76f190d5t	8	8	tcr	tcr	PROPN
pr76f190d5t	8	9	/	/	SYM
pr76f190d5t	8	10	peptide	peptide	NOUN
pr76f190d5t	8	11	residue	residue	NOUN
pr76f190d5t	8	12	pairs	pair	NOUN
pr76f190d5t	8	13	and	and	CCONJ
pr76f190d5t	8	14	the	the	DET
pr76f190d5t	8	15	tcr	tcr	PROPN
pr76f190d5t	8	16	/	/	SYM
pr76f190d5t	8	17	mhc	mhc	PROPN
pr76f190d5t	8	18	residue	residue	NOUN
pr76f190d5t	8	19	pairs	pair	NOUN
pr76f190d5t	8	20	,	,	PUNCT
pr76f190d5t	8	21	we	we	PRON
pr76f190d5t	8	22	can	can	AUX
pr76f190d5t	8	23	approximate	approximate	VERB
pr76f190d5t	8	24	the	the	DET
pr76f190d5t	8	25	relative	relative	ADJ
pr76f190d5t	8	26	contributions	contribution	NOUN
pr76f190d5t	8	27	of	of	ADP
pr76f190d5t	8	28	the	the	DET
pr76f190d5t	8	29	peptide	peptide	NOUN
pr76f190d5t	8	30	and	and	CCONJ
pr76f190d5t	8	31	the	the	DET
pr76f190d5t	8	32	mhc	mhc	NOUN
pr76f190d5t	8	33	to	to	ADP
pr76f190d5t	8	34	tcr	tcr	PROPN
pr76f190d5t	8	35	/	/	SYM
pr76f190d5t	8	36	pmhc	pmhc	NOUN
pr76f190d5t	8	37	binding	bind	VERB
pr76f190d5t	8	38	.	.	PUNCT
pr76f190d5t	9	1	double	double	ADJ
pr76f190d5t	9	2	-	-	PUNCT
pr76f190d5t	9	3	mutant	mutant	ADJ
pr76f190d5t	9	4	cycles	cycle	NOUN
pr76f190d5t	9	5	allow	allow	VERB
pr76f190d5t	9	6	us	we	PRON
pr76f190d5t	9	7	to	to	PART
pr76f190d5t	9	8	compare	compare	VERB
pr76f190d5t	9	9	the	the	DET
pr76f190d5t	9	10	contributions	contribution	NOUN
pr76f190d5t	9	11	to	to	ADP
pr76f190d5t	9	12	affinity	affinity	NOUN
pr76f190d5t	9	13	from	from	ADP
pr76f190d5t	9	14	contacts	contact	NOUN
pr76f190d5t	9	15	made	make	VERB
pr76f190d5t	9	16	by	by	ADP
pr76f190d5t	9	17	the	the	DET
pr76f190d5t	9	18	germline	germline	NOUN
pr76f190d5t	9	19	cdr	cdr	PROPN
pr76f190d5t	9	20	1&2	1&2	ADP
pr76f190d5t	9	21	loops	loop	NOUN
pr76f190d5t	9	22	and	and	CCONJ
pr76f190d5t	9	23	the	the	DET
pr76f190d5t	9	24	variable	variable	ADJ
pr76f190d5t	9	25	cdr3	cdr3	ADJ
pr76f190d5t	9	26	loops	loop	NOUN
pr76f190d5t	9	27	between	between	ADP
pr76f190d5t	9	28	the	the	DET
pr76f190d5t	9	29	a6	a6	ADJ
pr76f190d5t	9	30	tcr	tcr	NOUN
pr76f190d5t	9	31	and	and	CCONJ
pr76f190d5t	9	32	the	the	DET
pr76f190d5t	9	33	hla	hla	PROPN
pr76f190d5t	9	34	-	-	PUNCT
pr76f190d5t	9	35	a2	a2	NOUN
pr76f190d5t	9	36	/	/	SYM
pr76f190d5t	9	37	tax9	tax9	NOUN
pr76f190d5t	9	38	pmhc	pmhc	PROPN
pr76f190d5t	9	39	.	.	PUNCT
pr76f190d5t	10	1	our	our	PRON
pr76f190d5t	10	2	results	result	NOUN
pr76f190d5t	10	3	show	show	VERB
pr76f190d5t	10	4	a	a	DET
pr76f190d5t	10	5	strong	strong	ADJ
pr76f190d5t	10	6	favorable	favorable	ADJ
pr76f190d5t	10	7	interaction	interaction	NOUN
pr76f190d5t	10	8	energy	energy	NOUN
pr76f190d5t	10	9	between	between	ADP
pr76f190d5t	10	10	cdr3	cdr3	ADJ
pr76f190d5t	10	11	alpha	alpha	NOUN
pr76f190d5t	10	12	and	and	CCONJ
pr76f190d5t	10	13	the	the	DET
pr76f190d5t	10	14	mhc	mhc	NOUN
pr76f190d5t	10	15	.	.	PUNCT
pr76f190d5t	11	1	these	these	DET
pr76f190d5t	11	2	data	datum	NOUN
pr76f190d5t	11	3	suggest	suggest	VERB
pr76f190d5t	11	4	that	that	SCONJ
pr76f190d5t	11	5	despite	despite	SCONJ
pr76f190d5t	11	6	the	the	DET
pr76f190d5t	11	7	strong	strong	ADJ
pr76f190d5t	11	8	immunological	immunological	ADJ
pr76f190d5t	11	9	pressures	pressure	NOUN
pr76f190d5t	11	10	,	,	PUNCT
pr76f190d5t	11	11	the	the	DET
pr76f190d5t	11	12	energetic	energetic	ADJ
pr76f190d5t	11	13	profile	profile	NOUN
pr76f190d5t	11	14	of	of	ADP
pr76f190d5t	11	15	tcr	tcr	PROPN
pr76f190d5t	11	16	recognition	recognition	NOUN
pr76f190d5t	11	17	may	may	AUX
pr76f190d5t	11	18	be	be	AUX
pr76f190d5t	11	19	more	more	ADV
pr76f190d5t	11	20	malleable	malleable	ADJ
pr76f190d5t	11	21	or	or	CCONJ
pr76f190d5t	11	22	variable	variable	ADJ
pr76f190d5t	11	23	than	than	SCONJ
pr76f190d5t	11	24	previously	previously	ADV
pr76f190d5t	11	25	thought	think	VERB
pr76f190d5t	11	26	.	.	PUNCT