id	sid	tid	token	lemma	pos
pk02c824d00	1	1	proteins	protein	NOUN
pk02c824d00	1	2	regulate	regulate	VERB
pk02c824d00	1	3	many	many	ADJ
pk02c824d00	1	4	cellular	cellular	ADJ
pk02c824d00	1	5	functions	function	NOUN
pk02c824d00	1	6	,	,	PUNCT
pk02c824d00	1	7	and	and	CCONJ
pk02c824d00	1	8	analyzing	analyze	VERB
pk02c824d00	1	9	the	the	DET
pk02c824d00	1	10	presence	presence	NOUN
pk02c824d00	1	11	and	and	CCONJ
pk02c824d00	1	12	abundance	abundance	NOUN
pk02c824d00	1	13	of	of	ADP
pk02c824d00	1	14	proteins	protein	NOUN
pk02c824d00	1	15	in	in	ADP
pk02c824d00	1	16	biological	biological	ADJ
pk02c824d00	1	17	samples	sample	NOUN
pk02c824d00	1	18	are	be	AUX
pk02c824d00	1	19	central	central	ADJ
pk02c824d00	1	20	focuses	focus	NOUN
pk02c824d00	1	21	in	in	ADP
pk02c824d00	1	22	proteomics	proteomic	NOUN
pk02c824d00	1	23	.	.	PUNCT
pk02c824d00	2	1	the	the	DET
pk02c824d00	2	2	discovery	discovery	NOUN
pk02c824d00	2	3	and	and	CCONJ
pk02c824d00	2	4	validation	validation	NOUN
pk02c824d00	2	5	of	of	ADP
pk02c824d00	2	6	proteins	protein	NOUN
pk02c824d00	2	7	as	as	ADP
pk02c824d00	2	8	biomarkers	biomarker	NOUN
pk02c824d00	2	9	,	,	PUNCT
pk02c824d00	2	10	pathways	pathway	NOUN
pk02c824d00	2	11	,	,	PUNCT
pk02c824d00	2	12	and	and	CCONJ
pk02c824d00	2	13	drug	drug	NOUN
pk02c824d00	2	14	targets	target	NOUN
pk02c824d00	2	15	for	for	ADP
pk02c824d00	2	16	various	various	ADJ
pk02c824d00	2	17	diseases	disease	NOUN
pk02c824d00	2	18	can	can	AUX
pk02c824d00	2	19	be	be	AUX
pk02c824d00	2	20	accomplished	accomplish	VERB
pk02c824d00	2	21	using	use	VERB
pk02c824d00	2	22	mass	mass	ADJ
pk02c824d00	2	23	spectrometry	spectrometry	NOUN
pk02c824d00	2	24	-	-	PUNCT
pk02c824d00	2	25	based	base	VERB
pk02c824d00	2	26	proteomics	proteomic	NOUN
pk02c824d00	2	27	.	.	PUNCT
pk02c824d00	3	1	the	the	DET
pk02c824d00	3	2	mass	mass	NOUN
pk02c824d00	3	3	spectrometer	spectrometer	NOUN
pk02c824d00	3	4	is	be	AUX
pk02c824d00	3	5	a	a	DET
pk02c824d00	3	6	primary	primary	ADJ
pk02c824d00	3	7	player	player	NOUN
pk02c824d00	3	8	in	in	ADP
pk02c824d00	3	9	many	many	ADJ
pk02c824d00	3	10	proteomic	proteomic	ADJ
pk02c824d00	3	11	experiments	experiment	NOUN
pk02c824d00	3	12	;	;	PUNCT
pk02c824d00	3	13	however	however	ADV
pk02c824d00	3	14	,	,	PUNCT
pk02c824d00	3	15	the	the	DET
pk02c824d00	3	16	results	result	NOUN
pk02c824d00	3	17	obtained	obtain	VERB
pk02c824d00	3	18	from	from	ADP
pk02c824d00	3	19	the	the	DET
pk02c824d00	3	20	mass	mass	NOUN
pk02c824d00	3	21	spectrometer	spectrometer	NOUN
pk02c824d00	3	22	in	in	ADP
pk02c824d00	3	23	proteomic	proteomic	ADJ
pk02c824d00	3	24	experiments	experiment	NOUN
pk02c824d00	3	25	are	be	AUX
pk02c824d00	3	26	limited	limit	VERB
pk02c824d00	3	27	by	by	ADP
pk02c824d00	3	28	the	the	DET
pk02c824d00	3	29	quality	quality	NOUN
pk02c824d00	3	30	and	and	CCONJ
pk02c824d00	3	31	quantity	quantity	NOUN
pk02c824d00	3	32	of	of	ADP
pk02c824d00	3	33	the	the	DET
pk02c824d00	3	34	sample.regardless	sample.regardless	NOUN
pk02c824d00	3	35	of	of	ADP
pk02c824d00	3	36	the	the	DET
pk02c824d00	3	37	analysis	analysis	NOUN
pk02c824d00	3	38	approach	approach	NOUN
pk02c824d00	3	39	used	use	VERB
pk02c824d00	3	40	,	,	PUNCT
pk02c824d00	3	41	a	a	DET
pk02c824d00	3	42	high	high	ADJ
pk02c824d00	3	43	-	-	PUNCT
pk02c824d00	3	44	quality	quality	NOUN
pk02c824d00	3	45	sample	sample	NOUN
pk02c824d00	3	46	is	be	AUX
pk02c824d00	3	47	critical	critical	ADJ
pk02c824d00	3	48	for	for	ADP
pk02c824d00	3	49	a	a	DET
pk02c824d00	3	50	successful	successful	ADJ
pk02c824d00	3	51	experiment	experiment	NOUN
pk02c824d00	3	52	.	.	PUNCT
pk02c824d00	4	1	proteomic	proteomic	ADJ
pk02c824d00	4	2	analyses	analysis	NOUN
pk02c824d00	4	3	depend	depend	VERB
pk02c824d00	4	4	on	on	ADP
pk02c824d00	4	5	the	the	DET
pk02c824d00	4	6	sample	sample	NOUN
pk02c824d00	4	7	containing	contain	VERB
pk02c824d00	4	8	proteins	protein	NOUN
pk02c824d00	4	9	to	to	PART
pk02c824d00	4	10	analyze	analyze	VERB
pk02c824d00	4	11	.	.	PUNCT
pk02c824d00	5	1	there	there	PRON
pk02c824d00	5	2	are	be	VERB
pk02c824d00	5	3	several	several	ADJ
pk02c824d00	5	4	challenges	challenge	NOUN
pk02c824d00	5	5	in	in	ADP
pk02c824d00	5	6	proteomic	proteomic	ADJ
pk02c824d00	5	7	sample	sample	NOUN
pk02c824d00	5	8	preparation	preparation	NOUN
pk02c824d00	5	9	and	and	CCONJ
pk02c824d00	5	10	mass	mass	ADJ
pk02c824d00	5	11	spectrometry	spectrometry	NOUN
pk02c824d00	5	12	analysis	analysis	NOUN
pk02c824d00	5	13	.	.	PUNCT
pk02c824d00	6	1	protein	protein	NOUN
pk02c824d00	6	2	must	must	AUX
pk02c824d00	6	3	be	be	AUX
pk02c824d00	6	4	made	make	VERB
pk02c824d00	6	5	readily	readily	ADV
pk02c824d00	6	6	accessible	accessible	ADJ
pk02c824d00	6	7	via	via	ADP
pk02c824d00	6	8	lysis	lysis	NOUN
pk02c824d00	6	9	and	and	CCONJ
pk02c824d00	6	10	extraction	extraction	NOUN
pk02c824d00	6	11	from	from	ADP
pk02c824d00	6	12	the	the	DET
pk02c824d00	6	13	tissue	tissue	NOUN
pk02c824d00	6	14	or	or	CCONJ
pk02c824d00	6	15	cells	cell	NOUN
pk02c824d00	6	16	.	.	PUNCT
pk02c824d00	7	1	removal	removal	NOUN
pk02c824d00	7	2	of	of	ADP
pk02c824d00	7	3	natural	natural	ADJ
pk02c824d00	7	4	contaminants	contaminant	NOUN
pk02c824d00	7	5	and	and	CCONJ
pk02c824d00	7	6	introduced	introduce	VERB
pk02c824d00	7	7	detergents	detergent	NOUN
pk02c824d00	7	8	is	be	AUX
pk02c824d00	7	9	necessary	necessary	ADJ
pk02c824d00	7	10	.	.	PUNCT
pk02c824d00	8	1	contaminants	contaminant	NOUN
pk02c824d00	8	2	such	such	ADJ
pk02c824d00	8	3	as	as	ADP
pk02c824d00	8	4	lipids	lipid	NOUN
pk02c824d00	8	5	,	,	PUNCT
pk02c824d00	8	6	sds	sds	NOUN
pk02c824d00	8	7	or	or	CCONJ
pk02c824d00	8	8	other	other	ADJ
pk02c824d00	8	9	detergents	detergent	NOUN
pk02c824d00	8	10	,	,	PUNCT
pk02c824d00	8	11	and	and	CCONJ
pk02c824d00	8	12	salts	salt	NOUN
pk02c824d00	8	13	will	will	AUX
pk02c824d00	8	14	interfere	interfere	VERB
pk02c824d00	8	15	with	with	ADP
pk02c824d00	8	16	enzymatic	enzymatic	ADJ
pk02c824d00	8	17	digestion	digestion	NOUN
pk02c824d00	8	18	,	,	PUNCT
pk02c824d00	8	19	separations	separation	NOUN
pk02c824d00	8	20	and	and	CCONJ
pk02c824d00	8	21	mass	mass	ADJ
pk02c824d00	8	22	spectrometry	spectrometry	NOUN
pk02c824d00	8	23	,	,	PUNCT
pk02c824d00	8	24	sometimes	sometimes	ADV
pk02c824d00	8	25	damaging	damage	VERB
pk02c824d00	8	26	instruments	instrument	NOUN
pk02c824d00	8	27	and	and	CCONJ
pk02c824d00	8	28	irreversibly	irreversibly	ADV
pk02c824d00	8	29	ruining	ruin	VERB
pk02c824d00	8	30	columns	column	NOUN
pk02c824d00	8	31	.	.	PUNCT
pk02c824d00	9	1	sample	sample	NOUN
pk02c824d00	9	2	preparation	preparation	NOUN
pk02c824d00	9	3	approaches	approach	NOUN
pk02c824d00	9	4	that	that	PRON
pk02c824d00	9	5	are	be	AUX
pk02c824d00	9	6	excessively	excessively	ADV
pk02c824d00	9	7	time	time	NOUN
pk02c824d00	9	8	-	-	PUNCT
pk02c824d00	9	9	consuming	consume	VERB
pk02c824d00	9	10	,	,	PUNCT
pk02c824d00	9	11	incur	incur	VERB
pk02c824d00	9	12	massive	massive	ADJ
pk02c824d00	9	13	sample	sample	NOUN
pk02c824d00	9	14	losses	loss	NOUN
pk02c824d00	9	15	,	,	PUNCT
pk02c824d00	9	16	or	or	CCONJ
pk02c824d00	9	17	fail	fail	VERB
pk02c824d00	9	18	to	to	PART
pk02c824d00	9	19	prevent	prevent	VERB
pk02c824d00	9	20	irreversible	irreversible	ADJ
pk02c824d00	9	21	damage	damage	NOUN
pk02c824d00	9	22	require	require	NOUN
pk02c824d00	9	23	modification	modification	NOUN
pk02c824d00	9	24	or	or	CCONJ
pk02c824d00	9	25	replacement.this	replacement.this	NOUN
pk02c824d00	9	26	document	document	NOUN
pk02c824d00	9	27	demonstrates	demonstrate	VERB
pk02c824d00	9	28	my	my	PRON
pk02c824d00	9	29	focus	focus	NOUN
pk02c824d00	9	30	on	on	ADP
pk02c824d00	9	31	sample	sample	NOUN
pk02c824d00	9	32	preparation	preparation	NOUN
pk02c824d00	9	33	strategies	strategy	NOUN
pk02c824d00	9	34	for	for	ADP
pk02c824d00	9	35	bottom	bottom	ADJ
pk02c824d00	9	36	-	-	PUNCT
pk02c824d00	9	37	up	up	ADP
pk02c824d00	9	38	mass	mass	ADJ
pk02c824d00	9	39	spectrometry	spectrometry	NOUN
pk02c824d00	9	40	-	-	PUNCT
pk02c824d00	9	41	based	base	VERB
pk02c824d00	9	42	proteomics	proteomic	NOUN
pk02c824d00	9	43	.	.	PUNCT
pk02c824d00	10	1	the	the	DET
pk02c824d00	10	2	samples	sample	NOUN
pk02c824d00	10	3	presented	present	VERB
pk02c824d00	10	4	here	here	ADV
pk02c824d00	10	5	provide	provide	VERB
pk02c824d00	10	6	unique	unique	ADJ
pk02c824d00	10	7	analysis	analysis	NOUN
pk02c824d00	10	8	challenges	challenge	NOUN
pk02c824d00	10	9	.	.	PUNCT
pk02c824d00	11	1	much	much	ADJ
pk02c824d00	11	2	of	of	ADP
pk02c824d00	11	3	the	the	DET
pk02c824d00	11	4	work	work	NOUN
pk02c824d00	11	5	described	describe	VERB
pk02c824d00	11	6	here	here	ADV
pk02c824d00	11	7	focuses	focus	VERB
pk02c824d00	11	8	on	on	ADP
pk02c824d00	11	9	samples	sample	NOUN
pk02c824d00	11	10	that	that	PRON
pk02c824d00	11	11	are	be	AUX
pk02c824d00	11	12	easily	easily	ADV
pk02c824d00	11	13	lost	lose	VERB
pk02c824d00	11	14	,	,	PUNCT
pk02c824d00	11	15	require	require	VERB
pk02c824d00	11	16	specialized	specialized	ADJ
pk02c824d00	11	17	techniques	technique	NOUN
pk02c824d00	11	18	,	,	PUNCT
pk02c824d00	11	19	or	or	CCONJ
pk02c824d00	11	20	contain	contain	VERB
pk02c824d00	11	21	high	high	ADJ
pk02c824d00	11	22	levels	level	NOUN
pk02c824d00	11	23	of	of	ADP
pk02c824d00	11	24	natural	natural	ADJ
pk02c824d00	11	25	contaminants	contaminant	NOUN
pk02c824d00	11	26	that	that	PRON
pk02c824d00	11	27	interfere	interfere	VERB
pk02c824d00	11	28	with	with	ADP
pk02c824d00	11	29	the	the	DET
pk02c824d00	11	30	proteomic	proteomic	ADJ
pk02c824d00	11	31	workflow	workflow	NOUN
pk02c824d00	11	32	.	.	PUNCT
pk02c824d00	12	1	developing	develop	VERB
pk02c824d00	12	2	and	and	CCONJ
pk02c824d00	12	3	applying	apply	VERB
pk02c824d00	12	4	methods	method	NOUN
pk02c824d00	12	5	for	for	ADP
pk02c824d00	12	6	the	the	DET
pk02c824d00	12	7	use	use	NOUN
pk02c824d00	12	8	of	of	ADP
pk02c824d00	12	9	such	such	ADJ
pk02c824d00	12	10	intractable	intractable	ADJ
pk02c824d00	12	11	samples	sample	NOUN
pk02c824d00	12	12	provides	provide	VERB
pk02c824d00	12	13	opportunities	opportunity	NOUN
pk02c824d00	12	14	for	for	ADP
pk02c824d00	12	15	advancement	advancement	NOUN
pk02c824d00	12	16	of	of	ADP
pk02c824d00	12	17	scientific	scientific	ADJ
pk02c824d00	12	18	discoveries	discovery	NOUN
pk02c824d00	12	19	in	in	ADP
pk02c824d00	12	20	proteomics	proteomic	NOUN
pk02c824d00	12	21	.	.	PUNCT
pk02c824d00	13	1	the	the	DET
pk02c824d00	13	2	results	result	NOUN
pk02c824d00	13	3	of	of	ADP
pk02c824d00	13	4	my	my	PRON
pk02c824d00	13	5	method	method	NOUN
pk02c824d00	13	6	development	development	NOUN
pk02c824d00	13	7	efforts	effort	NOUN
pk02c824d00	13	8	include	include	VERB
pk02c824d00	13	9	the	the	DET
pk02c824d00	13	10	first	first	ADJ
pk02c824d00	13	11	proteomic	proteomic	ADJ
pk02c824d00	13	12	analysis	analysis	NOUN
pk02c824d00	13	13	of	of	ADP
pk02c824d00	13	14	individual	individual	ADJ
pk02c824d00	13	15	tumor	tumor	NOUN
pk02c824d00	13	16	mimics	mimic	NOUN
pk02c824d00	13	17	,	,	PUNCT
pk02c824d00	13	18	a	a	DET
pk02c824d00	13	19	novel	novel	ADJ
pk02c824d00	13	20	drug	drug	NOUN
pk02c824d00	13	21	evaluation	evaluation	NOUN
pk02c824d00	13	22	technique	technique	NOUN
pk02c824d00	13	23	,	,	PUNCT
pk02c824d00	13	24	and	and	CCONJ
pk02c824d00	13	25	a	a	DET
pk02c824d00	13	26	low	low	ADJ
pk02c824d00	13	27	-	-	PUNCT
pk02c824d00	13	28	cost	cost	NOUN
pk02c824d00	13	29	,	,	PUNCT
pk02c824d00	13	30	widely	widely	ADV
pk02c824d00	13	31	available	available	ADJ
pk02c824d00	13	32	method	method	NOUN
pk02c824d00	13	33	for	for	ADP
pk02c824d00	13	34	the	the	DET
pk02c824d00	13	35	analysis	analysis	NOUN
pk02c824d00	13	36	of	of	ADP
pk02c824d00	13	37	protein	protein	NOUN
pk02c824d00	13	38	from	from	ADP
pk02c824d00	13	39	adipose	adipose	ADJ
pk02c824d00	13	40	tissue	tissue	NOUN
pk02c824d00	13	41	depots	depot	NOUN
pk02c824d00	13	42	.	.	PUNCT