id	sid	tid	token	lemma	pos
pg15bc41d9h	1	1	identifying	identify	VERB
pg15bc41d9h	1	2	targetable	targetable	NOUN
pg15bc41d9h	1	3	and	and	CCONJ
pg15bc41d9h	1	4	cancer	cancer	NOUN
pg15bc41d9h	1	5	-	-	PUNCT
pg15bc41d9h	1	6	specific	specific	ADJ
pg15bc41d9h	1	7	vulnerability	vulnerability	NOUN
pg15bc41d9h	1	8	is	be	AUX
pg15bc41d9h	1	9	a	a	DET
pg15bc41d9h	1	10	prerequisite	prerequisite	NOUN
pg15bc41d9h	1	11	to	to	ADP
pg15bc41d9h	1	12	the	the	DET
pg15bc41d9h	1	13	development	development	NOUN
pg15bc41d9h	1	14	of	of	ADP
pg15bc41d9h	1	15	novel	novel	ADJ
pg15bc41d9h	1	16	personalized	personalize	VERB
pg15bc41d9h	1	17	cancer	cancer	NOUN
pg15bc41d9h	1	18	therapies	therapy	NOUN
pg15bc41d9h	1	19	.	.	PUNCT
pg15bc41d9h	2	1	lacking	lack	VERB
pg15bc41d9h	2	2	mechanistically	mechanistically	ADV
pg15bc41d9h	2	3	-	-	PUNCT
pg15bc41d9h	2	4	defined	define	VERB
pg15bc41d9h	2	5	and	and	CCONJ
pg15bc41d9h	2	6	targetable	targetable	ADJ
pg15bc41d9h	2	7	molecular	molecular	ADJ
pg15bc41d9h	2	8	drivers	driver	NOUN
pg15bc41d9h	2	9	,	,	PUNCT
pg15bc41d9h	2	10	triple	triple	ADJ
pg15bc41d9h	2	11	-	-	PUNCT
pg15bc41d9h	2	12	negative	negative	ADJ
pg15bc41d9h	2	13	breast	breast	NOUN
pg15bc41d9h	2	14	cancer	cancer	NOUN
pg15bc41d9h	2	15	(	(	PUNCT
pg15bc41d9h	2	16	tnbc	tnbc	PROPN
pg15bc41d9h	2	17	)	)	PUNCT
pg15bc41d9h	2	18	is	be	AUX
pg15bc41d9h	2	19	the	the	DET
pg15bc41d9h	2	20	most	most	ADV
pg15bc41d9h	2	21	clinically	clinically	ADV
pg15bc41d9h	2	22	-	-	PUNCT
pg15bc41d9h	2	23	challenging	challenge	VERB
pg15bc41d9h	2	24	breast	breast	NOUN
pg15bc41d9h	2	25	cancer	cancer	NOUN
pg15bc41d9h	2	26	subtypes	subtype	NOUN
pg15bc41d9h	2	27	.	.	PUNCT
pg15bc41d9h	3	1	in	in	ADP
pg15bc41d9h	3	2	this	this	DET
pg15bc41d9h	3	3	study	study	NOUN
pg15bc41d9h	3	4	,	,	PUNCT
pg15bc41d9h	3	5	through	through	ADP
pg15bc41d9h	3	6	a	a	DET
pg15bc41d9h	3	7	genome	genome	NOUN
pg15bc41d9h	3	8	-	-	PUNCT
pg15bc41d9h	3	9	wide	wide	ADJ
pg15bc41d9h	3	10	synthetic	synthetic	ADJ
pg15bc41d9h	3	11	lethal	lethal	ADJ
pg15bc41d9h	3	12	rnai	rnai	NOUN
pg15bc41d9h	3	13	screen	screen	NOUN
pg15bc41d9h	3	14	,	,	PUNCT
pg15bc41d9h	3	15	we	we	PRON
pg15bc41d9h	3	16	revealed	reveal	VERB
pg15bc41d9h	3	17	death	death	NOUN
pg15bc41d9h	3	18	effector	effector	NOUN
pg15bc41d9h	3	19	domain	domain	NOUN
pg15bc41d9h	3	20	-	-	PUNCT
pg15bc41d9h	3	21	containing	contain	VERB
pg15bc41d9h	3	22	dna	dna	NOUN
pg15bc41d9h	3	23	-	-	PUNCT
pg15bc41d9h	3	24	binding	bind	VERB
pg15bc41d9h	3	25	protein	protein	NOUN
pg15bc41d9h	3	26	(	(	PUNCT
pg15bc41d9h	3	27	dedd	dedd	X
pg15bc41d9h	3	28	)	)	PUNCT
pg15bc41d9h	3	29	drives	drive	VERB
pg15bc41d9h	3	30	a	a	DET
pg15bc41d9h	3	31	mitogen	mitogen	NOUN
pg15bc41d9h	3	32	-	-	PUNCT
pg15bc41d9h	3	33	independent	independent	ADJ
pg15bc41d9h	3	34	g1	g1	PROPN
pg15bc41d9h	3	35	/	/	SYM
pg15bc41d9h	3	36	s	s	PART
pg15bc41d9h	3	37	cell	cell	NOUN
pg15bc41d9h	3	38	cycle	cycle	NOUN
pg15bc41d9h	3	39	transition	transition	NOUN
pg15bc41d9h	3	40	in	in	ADP
pg15bc41d9h	3	41	tnbcs	tnbc	NOUN
pg15bc41d9h	3	42	,	,	PUNCT
pg15bc41d9h	3	43	independent	independent	ADJ
pg15bc41d9h	3	44	to	to	ADP
pg15bc41d9h	3	45	dedd	dedd	PROPN
pg15bc41d9h	3	46	's	's	PART
pg15bc41d9h	3	47	pro	pro	ADJ
pg15bc41d9h	3	48	-	-	ADJ
pg15bc41d9h	3	49	apoptotic	apoptotic	ADJ
pg15bc41d9h	3	50	functions	function	NOUN
pg15bc41d9h	3	51	in	in	ADP
pg15bc41d9h	3	52	the	the	DET
pg15bc41d9h	3	53	nucleus	nucleus	PROPN
pg15bc41d9h	3	54	.	.	PUNCT
pg15bc41d9h	4	1	overexpressed	overexpresse	VERB
pg15bc41d9h	4	2	in	in	ADP
pg15bc41d9h	4	3	&	&	CCONJ
pg15bc41d9h	4	4	gt;60	gt;60	SPACE
pg15bc41d9h	4	5	%	%	NOUN
pg15bc41d9h	4	6	tnbc	tnbc	PROPN
pg15bc41d9h	4	7	tumors	tumor	NOUN
pg15bc41d9h	4	8	,	,	PUNCT
pg15bc41d9h	4	9	cytosolic	cytosolic	NOUN
pg15bc41d9h	4	10	dedd	dedd	PROPN
pg15bc41d9h	4	11	facilitates	facilitate	VERB
pg15bc41d9h	4	12	an	an	DET
pg15bc41d9h	4	13	accelerated	accelerated	ADJ
pg15bc41d9h	4	14	cell	cell	NOUN
pg15bc41d9h	4	15	cycle	cycle	NOUN
pg15bc41d9h	4	16	progression	progression	NOUN
pg15bc41d9h	4	17	and	and	CCONJ
pg15bc41d9h	4	18	renders	render	VERB
pg15bc41d9h	4	19	tnbc	tnbc	PROPN
pg15bc41d9h	4	20	cells	cell	NOUN
pg15bc41d9h	4	21	vulnerable	vulnerable	ADJ
pg15bc41d9h	4	22	to	to	ADP
pg15bc41d9h	4	23	cell	cell	NOUN
pg15bc41d9h	4	24	cycle	cycle	NOUN
pg15bc41d9h	4	25	inhibition	inhibition	NOUN
pg15bc41d9h	4	26	.	.	PUNCT
pg15bc41d9h	5	1	mechanically	mechanically	ADV
pg15bc41d9h	5	2	,	,	PUNCT
pg15bc41d9h	5	3	the	the	DET
pg15bc41d9h	5	4	gain	gain	NOUN
pg15bc41d9h	5	5	of	of	ADP
pg15bc41d9h	5	6	cytosolic	cytosolic	NOUN
pg15bc41d9h	5	7	dedd	dedd	NOUN
pg15bc41d9h	5	8	enhances	enhance	VERB
pg15bc41d9h	5	9	cyclin	cyclin	NOUN
pg15bc41d9h	5	10	d1	d1	PROPN
pg15bc41d9h	5	11	expression	expression	NOUN
pg15bc41d9h	5	12	by	by	ADP
pg15bc41d9h	5	13	interacting	interact	VERB
pg15bc41d9h	5	14	with	with	ADP
pg15bc41d9h	5	15	heat	heat	NOUN
pg15bc41d9h	5	16	shock	shock	NOUN
pg15bc41d9h	5	17	protein	protein	NOUN
pg15bc41d9h	5	18	hsc70	hsc70	PROPN
pg15bc41d9h	5	19	.	.	PUNCT
pg15bc41d9h	6	1	concurrently	concurrently	ADV
pg15bc41d9h	6	2	,	,	PUNCT
pg15bc41d9h	6	3	dedd	dedd	PROPN
pg15bc41d9h	6	4	interacts	interact	VERB
pg15bc41d9h	6	5	with	with	ADP
pg15bc41d9h	6	6	tumor	tumor	NOUN
pg15bc41d9h	6	7	suppressor	suppressor	NOUN
pg15bc41d9h	6	8	rb	rb	PROPN
pg15bc41d9h	6	9	family	family	NOUN
pg15bc41d9h	6	10	proteins	protein	NOUN
pg15bc41d9h	6	11	and	and	CCONJ
pg15bc41d9h	6	12	promotes	promote	VERB
pg15bc41d9h	6	13	their	their	PRON
pg15bc41d9h	6	14	proteasome	proteasome	NOUN
pg15bc41d9h	6	15	-	-	PUNCT
pg15bc41d9h	6	16	mediated	mediate	VERB
pg15bc41d9h	6	17	degradation	degradation	NOUN
pg15bc41d9h	6	18	,	,	PUNCT
pg15bc41d9h	6	19	further	far	ADV
pg15bc41d9h	6	20	contributing	contribute	VERB
pg15bc41d9h	6	21	to	to	ADP
pg15bc41d9h	6	22	the	the	DET
pg15bc41d9h	6	23	accelerated	accelerated	ADJ
pg15bc41d9h	6	24	g1	g1	PROPN
pg15bc41d9h	6	25	/	/	SYM
pg15bc41d9h	6	26	s	s	NOUN
pg15bc41d9h	6	27	cell	cell	NOUN
pg15bc41d9h	6	28	cycle	cycle	NOUN
pg15bc41d9h	6	29	progression	progression	NOUN
pg15bc41d9h	6	30	.	.	PUNCT
pg15bc41d9h	7	1	clinically	clinically	ADV
pg15bc41d9h	7	2	,	,	PUNCT
pg15bc41d9h	7	3	despite	despite	SCONJ
pg15bc41d9h	7	4	the	the	DET
pg15bc41d9h	7	5	successes	success	NOUN
pg15bc41d9h	7	6	of	of	ADP
pg15bc41d9h	7	7	cyclin	cyclin	NOUN
pg15bc41d9h	7	8	d	d	PROPN
pg15bc41d9h	7	9	kinase	kinase	PROPN
pg15bc41d9h	7	10	cdk	cdk	VERB
pg15bc41d9h	7	11	4/6	4/6	NUM
pg15bc41d9h	7	12	inhibitors	inhibitor	NOUN
pg15bc41d9h	7	13	in	in	ADP
pg15bc41d9h	7	14	breast	breast	NOUN
pg15bc41d9h	7	15	cancer	cancer	NOUN
pg15bc41d9h	7	16	,	,	PUNCT
pg15bc41d9h	7	17	tnbc	tnbc	PROPN
pg15bc41d9h	7	18	patients	patient	NOUN
pg15bc41d9h	7	19	have	have	AUX
pg15bc41d9h	7	20	been	be	AUX
pg15bc41d9h	7	21	excluded	exclude	VERB
pg15bc41d9h	7	22	from	from	ADP
pg15bc41d9h	7	23	cdk	cdk	ADJ
pg15bc41d9h	7	24	4/6	4/6	NUM
pg15bc41d9h	7	25	inhibitors	inhibitor	NOUN
pg15bc41d9h	7	26	clinical	clinical	ADJ
pg15bc41d9h	7	27	trials	trial	NOUN
pg15bc41d9h	7	28	due	due	ADP
pg15bc41d9h	7	29	to	to	ADP
pg15bc41d9h	7	30	the	the	DET
pg15bc41d9h	7	31	perceived	perceive	VERB
pg15bc41d9h	7	32	high	high	ADJ
pg15bc41d9h	7	33	frequency	frequency	NOUN
pg15bc41d9h	7	34	of	of	ADP
pg15bc41d9h	7	35	rb	rb	PROPN
pg15bc41d9h	7	36	loss	loss	PROPN
pg15bc41d9h	7	37	.	.	PUNCT
pg15bc41d9h	8	1	contrary	contrary	ADJ
pg15bc41d9h	8	2	to	to	ADP
pg15bc41d9h	8	3	this	this	DET
pg15bc41d9h	8	4	prevailing	prevail	VERB
pg15bc41d9h	8	5	notion	notion	NOUN
pg15bc41d9h	8	6	,	,	PUNCT
pg15bc41d9h	8	7	my	my	PRON
pg15bc41d9h	8	8	study	study	NOUN
pg15bc41d9h	8	9	demonstrated	demonstrate	VERB
pg15bc41d9h	8	10	that	that	SCONJ
pg15bc41d9h	8	11	,	,	PUNCT
pg15bc41d9h	8	12	regardless	regardless	ADV
pg15bc41d9h	8	13	of	of	ADP
pg15bc41d9h	8	14	rb	rb	PROPN
pg15bc41d9h	8	15	status	status	NOUN
pg15bc41d9h	8	16	,	,	PUNCT
pg15bc41d9h	8	17	tnbcs	tnbc	NOUN
pg15bc41d9h	8	18	with	with	ADP
pg15bc41d9h	8	19	dedd	dedd	PROPN
pg15bc41d9h	8	20	overexpression	overexpression	NOUN
pg15bc41d9h	8	21	exhibit	exhibit	VERB
pg15bc41d9h	8	22	a	a	DET
pg15bc41d9h	8	23	dedd	dedd	NOUN
pg15bc41d9h	8	24	-	-	PUNCT
pg15bc41d9h	8	25	dependent	dependent	ADJ
pg15bc41d9h	8	26	vulnerability	vulnerability	NOUN
pg15bc41d9h	8	27	to	to	ADP
pg15bc41d9h	8	28	the	the	DET
pg15bc41d9h	8	29	combinatorial	combinatorial	ADJ
pg15bc41d9h	8	30	treatment	treatment	NOUN
pg15bc41d9h	8	31	of	of	ADP
pg15bc41d9h	8	32	cdk4/6	cdk4/6	NUM
pg15bc41d9h	8	33	inhibitor	inhibitor	NOUN
pg15bc41d9h	8	34	and	and	CCONJ
pg15bc41d9h	8	35	egfr	egfr	PROPN
pg15bc41d9h	8	36	inhibitor	inhibitor	NOUN
pg15bc41d9h	8	37	in	in	ADP
pg15bc41d9h	8	38	vitro	vitro	X
pg15bc41d9h	8	39	and	and	CCONJ
pg15bc41d9h	8	40	in	in	ADP
pg15bc41d9h	8	41	vivo	vivo	PROPN
pg15bc41d9h	8	42	.	.	PROPN
pg15bc41d9h	9	1	taken	take	VERB
pg15bc41d9h	9	2	together	together	ADV
pg15bc41d9h	9	3	,	,	PUNCT
pg15bc41d9h	9	4	my	my	PRON
pg15bc41d9h	9	5	study	study	NOUN
pg15bc41d9h	9	6	revealed	reveal	VERB
pg15bc41d9h	9	7	a	a	DET
pg15bc41d9h	9	8	tnbc	tnbc	ADV
pg15bc41d9h	9	9	-	-	PUNCT
pg15bc41d9h	9	10	specific	specific	ADJ
pg15bc41d9h	9	11	vulnerability	vulnerability	NOUN
pg15bc41d9h	9	12	conferred	confer	VERB
pg15bc41d9h	9	13	by	by	ADP
pg15bc41d9h	9	14	dedd	dedd	PROPN
pg15bc41d9h	9	15	-	-	PUNCT
pg15bc41d9h	9	16	driven	drive	VERB
pg15bc41d9h	9	17	dysregulated	dysregulate	VERB
pg15bc41d9h	9	18	cell	cell	NOUN
pg15bc41d9h	9	19	cycle	cycle	NOUN
pg15bc41d9h	9	20	progression	progression	NOUN
pg15bc41d9h	9	21	and	and	CCONJ
pg15bc41d9h	9	22	provided	provide	VERB
pg15bc41d9h	9	23	a	a	DET
pg15bc41d9h	9	24	rationale	rationale	NOUN
pg15bc41d9h	9	25	for	for	ADP
pg15bc41d9h	9	26	the	the	DET
pg15bc41d9h	9	27	clinical	clinical	ADJ
pg15bc41d9h	9	28	application	application	NOUN
pg15bc41d9h	9	29	of	of	ADP
pg15bc41d9h	9	30	cdk4/6	cdk4/6	DET
pg15bc41d9h	9	31	inhibitor	inhibitor	NOUN
pg15bc41d9h	9	32	containing	contain	VERB
pg15bc41d9h	9	33	combinatorial	combinatorial	ADJ
pg15bc41d9h	9	34	regimens	regimen	NOUN
pg15bc41d9h	9	35	for	for	ADP
pg15bc41d9h	9	36	tnbc	tnbc	ADJ
pg15bc41d9h	9	37	patients	patient	NOUN
pg15bc41d9h	9	38	.	.	PUNCT