id sid tid token lemma pos p8418k7419w 1 1 allopregnanolone allopregnanolone NOUN p8418k7419w 1 2 is be AUX p8418k7419w 1 3 a a DET p8418k7419w 1 4 neurosteroid neurosteroid ADJ p8418k7419w 1 5 and and CCONJ p8418k7419w 1 6 reduced reduce VERB p8418k7419w 1 7 progesterone progesterone NOUN p8418k7419w 1 8 metabolite metabolite NOUN p8418k7419w 1 9 synthesized synthesize VERB p8418k7419w 1 10 in in ADP p8418k7419w 1 11 the the DET p8418k7419w 1 12 nervous nervous ADJ p8418k7419w 1 13 system system NOUN p8418k7419w 1 14 of of ADP p8418k7419w 1 15 vertebrates vertebrate NOUN p8418k7419w 1 16 . . PUNCT p8418k7419w 2 1 allopregnanolone allopregnanolone NOUN p8418k7419w 2 2 is be AUX p8418k7419w 2 3 an an DET p8418k7419w 2 4 antiepileptic antiepileptic ADJ p8418k7419w 2 5 , , PUNCT p8418k7419w 2 6 anxiolytic anxiolytic ADJ p8418k7419w 2 7 , , PUNCT p8418k7419w 2 8 mood mood NOUN p8418k7419w 2 9 elevating elevate VERB p8418k7419w 2 10 drug drug NOUN p8418k7419w 2 11 and and CCONJ p8418k7419w 2 12 emerging emerge VERB p8418k7419w 2 13 as as ADP p8418k7419w 2 14 a a DET p8418k7419w 2 15 therapeutic therapeutic ADJ p8418k7419w 2 16 choice choice NOUN p8418k7419w 2 17 for for ADP p8418k7419w 2 18 neuropsychiatric neuropsychiatric ADJ p8418k7419w 2 19 and and CCONJ p8418k7419w 2 20 neurodegenerative neurodegenerative ADJ p8418k7419w 2 21 disorders disorder NOUN p8418k7419w 2 22 . . PUNCT p8418k7419w 3 1 allopregnanolone allopregnanolone NOUN p8418k7419w 3 2 modulates modulate VERB p8418k7419w 3 3 neuronal neuronal ADJ p8418k7419w 3 4 functions function NOUN p8418k7419w 3 5 via via ADP p8418k7419w 3 6 both both CCONJ p8418k7419w 3 7 nongenomic nongenomic ADJ p8418k7419w 3 8 and and CCONJ p8418k7419w 3 9 genomic genomic ADJ p8418k7419w 3 10 mechanisms mechanism NOUN p8418k7419w 3 11 . . PUNCT p8418k7419w 4 1 however however ADV p8418k7419w 4 2 , , PUNCT p8418k7419w 4 3 the the DET p8418k7419w 4 4 genomic genomic ADJ p8418k7419w 4 5 effects effect NOUN p8418k7419w 4 6 of of ADP p8418k7419w 4 7 allopregnanolone allopregnanolone NOUN p8418k7419w 4 8 are be AUX p8418k7419w 4 9 poorly poorly ADV p8418k7419w 4 10 understood understand VERB p8418k7419w 4 11 . . PUNCT p8418k7419w 5 1 allopregnanolone allopregnanolone NOUN p8418k7419w 5 2 also also ADV p8418k7419w 5 3 alters alter VERB p8418k7419w 5 4 various various ADJ p8418k7419w 5 5 behavior behavior NOUN p8418k7419w 5 6 patterns pattern NOUN p8418k7419w 5 7 including include VERB p8418k7419w 5 8 learning learning NOUN p8418k7419w 5 9 and and CCONJ p8418k7419w 5 10 memory memory NOUN p8418k7419w 5 11 but but CCONJ p8418k7419w 5 12 the the DET p8418k7419w 5 13 mechanisms mechanism NOUN p8418k7419w 5 14 involved involve VERB p8418k7419w 5 15 beyond beyond ADP p8418k7419w 5 16 this this PRON p8418k7419w 5 17 largely largely ADV p8418k7419w 5 18 remain remain VERB p8418k7419w 5 19 unknown unknown ADJ p8418k7419w 5 20 . . PUNCT p8418k7419w 6 1 in in ADP p8418k7419w 6 2 amphibian amphibian ADJ p8418k7419w 6 3 brains brain NOUN p8418k7419w 6 4 , , PUNCT p8418k7419w 6 5 synthesis synthesis NOUN p8418k7419w 6 6 of of ADP p8418k7419w 6 7 various various ADJ p8418k7419w 6 8 neurosteorids neurosteorid NOUN p8418k7419w 6 9 is be AUX p8418k7419w 6 10 well well ADV p8418k7419w 6 11 established establish VERB p8418k7419w 6 12 , , PUNCT p8418k7419w 6 13 however however ADV p8418k7419w 6 14 the the DET p8418k7419w 6 15 endogenous endogenous ADJ p8418k7419w 6 16 synthesis synthesis NOUN p8418k7419w 6 17 of of ADP p8418k7419w 6 18 5 5 NUM p8418k7419w 6 19 alpha alpha NOUN p8418k7419w 6 20 and and CCONJ p8418k7419w 6 21 5 5 NUM p8418k7419w 6 22 alpha-3 alpha-3 NOUN p8418k7419w 6 23 alpha alpha NOUN p8418k7419w 6 24 reduced reduce VERB p8418k7419w 6 25 neurosteroids neurosteroid NOUN p8418k7419w 6 26 such such ADJ p8418k7419w 6 27 as as ADP p8418k7419w 6 28 allopregnanolone allopregnanolone NOUN p8418k7419w 6 29 , , PUNCT p8418k7419w 6 30 thdoc thdoc PROPN p8418k7419w 6 31 and and CCONJ p8418k7419w 6 32 androstanediol androstanediol PROPN p8418k7419w 6 33 , , PUNCT p8418k7419w 6 34 in in ADP p8418k7419w 6 35 amphibian amphibian ADJ p8418k7419w 6 36 brain brain NOUN p8418k7419w 6 37 is be AUX p8418k7419w 6 38 not not PART p8418k7419w 6 39 demonstrated demonstrate VERB p8418k7419w 6 40 yet yet ADV p8418k7419w 6 41 . . PUNCT p8418k7419w 7 1 the the DET p8418k7419w 7 2 studies study NOUN p8418k7419w 7 3 in in ADP p8418k7419w 7 4 this this DET p8418k7419w 7 5 project project NOUN p8418k7419w 7 6 include include VERB p8418k7419w 7 7 three three NUM p8418k7419w 7 8 main main ADJ p8418k7419w 7 9 objectives objective NOUN p8418k7419w 7 10 . . PUNCT p8418k7419w 8 1 first first ADV p8418k7419w 8 2 , , PUNCT p8418k7419w 8 3 we we PRON p8418k7419w 8 4 examined examine VERB p8418k7419w 8 5 the the DET p8418k7419w 8 6 global global ADJ p8418k7419w 8 7 genomic genomic ADJ p8418k7419w 8 8 effects effect NOUN p8418k7419w 8 9 of of ADP p8418k7419w 8 10 allopregnanolone allopregnanolone NOUN p8418k7419w 8 11 on on ADP p8418k7419w 8 12 neuroendocrine neuroendocrine NOUN p8418k7419w 8 13 circuits circuit NOUN p8418k7419w 8 14 using use VERB p8418k7419w 8 15 amphibian amphibian PROPN p8418k7419w 8 16 ( ( PUNCT p8418k7419w 8 17 xenoups xenoups X p8418k7419w 8 18 laevis laevis PROPN p8418k7419w 8 19 ) ) PUNCT p8418k7419w 8 20 brain brain NOUN p8418k7419w 8 21 . . PUNCT p8418k7419w 9 1 second second ADJ p8418k7419w 9 2 , , PUNCT p8418k7419w 9 3 we we PRON p8418k7419w 9 4 studied study VERB p8418k7419w 9 5 the the DET p8418k7419w 9 6 role role NOUN p8418k7419w 9 7 of of ADP p8418k7419w 9 8 allopregnanolone allopregnanolone NOUN p8418k7419w 9 9 on on ADP p8418k7419w 9 10 intracellular intracellular ADJ p8418k7419w 9 11 signaling signal VERB p8418k7419w 9 12 mechanisms mechanism NOUN p8418k7419w 9 13 of of ADP p8418k7419w 9 14 synaptic synaptic ADJ p8418k7419w 9 15 plasticity plasticity NOUN p8418k7419w 9 16 -- -- PUNCT p8418k7419w 9 17 a a DET p8418k7419w 9 18 basic basic ADJ p8418k7419w 9 19 conserved conserved ADJ p8418k7419w 9 20 cellular cellular ADJ p8418k7419w 9 21 mechanism mechanism NOUN p8418k7419w 9 22 underlying underlie VERB p8418k7419w 9 23 learning learning NOUN p8418k7419w 9 24 and and CCONJ p8418k7419w 9 25 memory memory NOUN p8418k7419w 9 26 formation formation NOUN p8418k7419w 9 27 . . PUNCT p8418k7419w 10 1 third third ADJ p8418k7419w 10 2 , , PUNCT p8418k7419w 10 3 we we PRON p8418k7419w 10 4 studied study VERB p8418k7419w 10 5 the the DET p8418k7419w 10 6 expression expression NOUN p8418k7419w 10 7 and and CCONJ p8418k7419w 10 8 localization localization NOUN p8418k7419w 10 9 patterns pattern NOUN p8418k7419w 10 10 of of ADP p8418k7419w 10 11 mrna mrna PROPN p8418k7419w 10 12 encoding encode VERB p8418k7419w 10 13 steroidogenic steroidogenic ADJ p8418k7419w 10 14 enzymes enzyme NOUN p8418k7419w 10 15 that that PRON p8418k7419w 10 16 are be AUX p8418k7419w 10 17 involved involve VERB p8418k7419w 10 18 in in ADP p8418k7419w 10 19 5 5 NUM p8418k7419w 10 20 alpha alpha NOUN p8418k7419w 10 21 and and CCONJ p8418k7419w 10 22 5 5 NUM p8418k7419w 10 23 alpha-3alpha alpha-3alpha NOUN p8418k7419w 10 24 reduced reduce VERB p8418k7419w 10 25 neurosteroid neurosteroid ADJ p8418k7419w 10 26 synthesis synthesis NOUN p8418k7419w 10 27 in in ADP p8418k7419w 10 28 amphibian amphibian ADJ p8418k7419w 10 29 brain brain NOUN p8418k7419w 10 30 . . PUNCT p8418k7419w 11 1 to to PART p8418k7419w 11 2 study study VERB p8418k7419w 11 3 the the DET p8418k7419w 11 4 global global ADJ p8418k7419w 11 5 genomic genomic ADJ p8418k7419w 11 6 effects effect NOUN p8418k7419w 11 7 of of ADP p8418k7419w 11 8 allopregnanolone allopregnanolone NOUN p8418k7419w 11 9 , , PUNCT p8418k7419w 11 10 isolated isolate VERB p8418k7419w 11 11 in in ADP p8418k7419w 11 12 vitro vitro X p8418k7419w 11 13 brains brain NOUN p8418k7419w 11 14 were be AUX p8418k7419w 11 15 treated treat VERB p8418k7419w 11 16 with with ADP p8418k7419w 11 17 micromolar micromolar ADJ p8418k7419w 11 18 doses dose NOUN p8418k7419w 11 19 of of ADP p8418k7419w 11 20 allopregnanolone allopregnanolone NOUN p8418k7419w 11 21 . . PUNCT p8418k7419w 12 1 using use VERB p8418k7419w 12 2 microarray microarray PROPN p8418k7419w 12 3 technology technology NOUN p8418k7419w 12 4 and and CCONJ p8418k7419w 12 5 bioinformatic bioinformatic ADJ p8418k7419w 12 6 tools tool NOUN p8418k7419w 12 7 , , PUNCT p8418k7419w 12 8 we we PRON p8418k7419w 12 9 identified identify VERB p8418k7419w 12 10 novel novel ADJ p8418k7419w 12 11 regulatory regulatory ADJ p8418k7419w 12 12 roles role NOUN p8418k7419w 12 13 for for ADP p8418k7419w 12 14 allopregnanolone allopregnanolone NOUN p8418k7419w 12 15 on on ADP p8418k7419w 12 16 various various ADJ p8418k7419w 12 17 neuroendocrine neuroendocrine NOUN p8418k7419w 12 18 and and CCONJ p8418k7419w 12 19 neurotransmitter neurotransmitter NOUN p8418k7419w 12 20 circuits circuit NOUN p8418k7419w 12 21 at at ADP p8418k7419w 12 22 the the DET p8418k7419w 12 23 transcript transcript NOUN p8418k7419w 12 24 level level NOUN p8418k7419w 12 25 . . PUNCT p8418k7419w 13 1 allopregnanolone allopregnanolone NOUN p8418k7419w 13 2 regulated regulate VERB p8418k7419w 13 3 several several ADJ p8418k7419w 13 4 critical critical ADJ p8418k7419w 13 5 transcription transcription NOUN p8418k7419w 13 6 factors factor NOUN p8418k7419w 13 7 and and CCONJ p8418k7419w 13 8 genes gene NOUN p8418k7419w 13 9 involved involve VERB p8418k7419w 13 10 in in ADP p8418k7419w 13 11 the the DET p8418k7419w 13 12 neuronal neuronal ADJ p8418k7419w 13 13 cell cell NOUN p8418k7419w 13 14 cycle cycle NOUN p8418k7419w 13 15 , , PUNCT p8418k7419w 13 16 differentiation differentiation NOUN p8418k7419w 13 17 , , PUNCT p8418k7419w 13 18 development development NOUN p8418k7419w 13 19 , , PUNCT p8418k7419w 13 20 neurite neurite ADJ p8418k7419w 13 21 growth growth NOUN p8418k7419w 13 22 , , PUNCT p8418k7419w 13 23 axon axon NOUN p8418k7419w 13 24 guidance guidance NOUN p8418k7419w 13 25 , , PUNCT p8418k7419w 13 26 cytoskeletal cytoskeletal ADJ p8418k7419w 13 27 remodeling remodeling NOUN p8418k7419w 13 28 , , PUNCT p8418k7419w 13 29 neurodegeneration neurodegeneration NOUN p8418k7419w 13 30 and and CCONJ p8418k7419w 13 31 inflammatory inflammatory ADJ p8418k7419w 13 32 processes process NOUN p8418k7419w 13 33 . . PUNCT p8418k7419w 14 1 to to PART p8418k7419w 14 2 identify identify VERB p8418k7419w 14 3 the the DET p8418k7419w 14 4 potential potential ADJ p8418k7419w 14 5 role role NOUN p8418k7419w 14 6 of of ADP p8418k7419w 14 7 allopregnanolone allopregnanolone NOUN p8418k7419w 14 8 on on ADP p8418k7419w 14 9 intracellular intracellular ADJ p8418k7419w 14 10 signaling signal VERB p8418k7419w 14 11 mechanisms mechanism NOUN p8418k7419w 14 12 of of ADP p8418k7419w 14 13 synaptic synaptic NOUN p8418k7419w 14 14 plasticity plasticity NOUN p8418k7419w 14 15 , , PUNCT p8418k7419w 14 16 isolated isolate VERB p8418k7419w 14 17 in in ADP p8418k7419w 14 18 vitro vitro X p8418k7419w 14 19 brains brain NOUN p8418k7419w 14 20 were be AUX p8418k7419w 14 21 treated treat VERB p8418k7419w 14 22 with with ADP p8418k7419w 14 23 a a DET p8418k7419w 14 24 wide wide ADJ p8418k7419w 14 25 range range NOUN p8418k7419w 14 26 of of ADP p8418k7419w 14 27 allopregnanolone allopregnanolone NOUN p8418k7419w 14 28 doses dose NOUN p8418k7419w 14 29 with with ADP p8418k7419w 14 30 or or CCONJ p8418k7419w 14 31 without without ADP p8418k7419w 14 32 an an DET p8418k7419w 14 33 nmda nmda ADJ p8418k7419w 14 34 receptor receptor NOUN p8418k7419w 14 35 blocker blocker NOUN p8418k7419w 14 36 . . PUNCT p8418k7419w 15 1 allopregnanolone allopregnanolone NOUN p8418k7419w 15 2 regulated regulate VERB p8418k7419w 15 3 the the DET p8418k7419w 15 4 molecular molecular ADJ p8418k7419w 15 5 signaling signal VERB p8418k7419w 15 6 components component NOUN p8418k7419w 15 7 implicated implicate VERB p8418k7419w 15 8 in in ADP p8418k7419w 15 9 cerebellar cerebellar ADJ p8418k7419w 15 10 longterm longterm NOUN p8418k7419w 15 11 depression depression NOUN p8418k7419w 15 12 , , PUNCT p8418k7419w 15 13 fear fear VERB p8418k7419w 15 14 conditioned condition VERB p8418k7419w 15 15 plasticity plasticity NOUN p8418k7419w 15 16 and and CCONJ p8418k7419w 15 17 bidirectional bidirectional ADJ p8418k7419w 15 18 synaptic synaptic NOUN p8418k7419w 15 19 plasticity plasticity NOUN p8418k7419w 15 20 . . PUNCT p8418k7419w 16 1 as as ADP p8418k7419w 16 2 a a DET p8418k7419w 16 3 third third ADJ p8418k7419w 16 4 project project NOUN p8418k7419w 16 5 , , PUNCT p8418k7419w 16 6 in in ADP p8418k7419w 16 7 situ situ NOUN p8418k7419w 16 8 hybridization hybridization NOUN p8418k7419w 16 9 and and CCONJ p8418k7419w 16 10 reverse reverse ADJ p8418k7419w 16 11 transcription transcription NOUN p8418k7419w 16 12 pcr pcr NOUN p8418k7419w 16 13 studies study NOUN p8418k7419w 16 14 demonstrated demonstrate VERB p8418k7419w 16 15 that that SCONJ p8418k7419w 16 16 expression expression NOUN p8418k7419w 16 17 of of ADP p8418k7419w 16 18 mrna mrna PROPN p8418k7419w 16 19 encoding encode VERB p8418k7419w 16 20 the the DET p8418k7419w 16 21 steroidogenic steroidogenic ADJ p8418k7419w 16 22 enzymes enzyme NOUN p8418k7419w 16 23 srd5a1 srd5a1 NOUN p8418k7419w 16 24 , , PUNCT p8418k7419w 16 25 srd5a3 srd5a3 PROPN p8418k7419w 16 26 and and CCONJ p8418k7419w 16 27 akr1c2 akr1c2 NOUN p8418k7419w 16 28 is be AUX p8418k7419w 16 29 wide wide ADV p8418k7419w 16 30 spread spread VERB p8418k7419w 16 31 across across ADP p8418k7419w 16 32 the the DET p8418k7419w 16 33 amphibian amphibian ADJ p8418k7419w 16 34 brain brain NOUN p8418k7419w 16 35 . . PUNCT p8418k7419w 17 1 the the DET p8418k7419w 17 2 localization localization NOUN p8418k7419w 17 3 patterns pattern NOUN p8418k7419w 17 4 of of ADP p8418k7419w 17 5 mrna mrna PROPN p8418k7419w 17 6 suggests suggest VERB p8418k7419w 17 7 a a DET p8418k7419w 17 8 possible possible ADJ p8418k7419w 17 9 functional functional ADJ p8418k7419w 17 10 role role NOUN p8418k7419w 17 11 of of ADP p8418k7419w 17 12 5 5 NUM p8418k7419w 17 13 alpha alpha NOUN p8418k7419w 17 14 and and CCONJ p8418k7419w 17 15 ( ( PUNCT p8418k7419w 17 16 or or CCONJ p8418k7419w 17 17 ) ) PUNCT p8418k7419w 17 18 5 5 NUM p8418k7419w 17 19 alpha-3 alpha-3 NOUN p8418k7419w 17 20 alpha alpha NOUN p8418k7419w 17 21 reduced reduce VERB p8418k7419w 17 22 neurosteroids neurosteroid NOUN p8418k7419w 17 23 in in ADP p8418k7419w 17 24 olfaction olfaction NOUN p8418k7419w 17 25 , , PUNCT p8418k7419w 17 26 multimodal multimodal ADJ p8418k7419w 17 27 sensory sensory ADJ p8418k7419w 17 28 integration integration NOUN p8418k7419w 17 29 , , PUNCT p8418k7419w 17 30 auditory auditory ADJ p8418k7419w 17 31 communication communication NOUN p8418k7419w 17 32 and and CCONJ p8418k7419w 17 33 neuroendocrine neuroendocrine NOUN p8418k7419w 17 34 systems system NOUN p8418k7419w 17 35 of of ADP p8418k7419w 17 36 amphibians amphibian NOUN p8418k7419w 17 37 . . PUNCT p8418k7419w 18 1 the the DET p8418k7419w 18 2 expression expression NOUN p8418k7419w 18 3 of of ADP p8418k7419w 18 4 mrna mrna PROPN p8418k7419w 18 5 encoding encoding PROPN p8418k7419w 18 6 srd5a3 srd5a3 PROPN p8418k7419w 18 7 enzyme enzyme PROPN p8418k7419w 18 8 , , PUNCT p8418k7419w 18 9 a a DET p8418k7419w 18 10 novel novel ADJ p8418k7419w 18 11 isoform isoform NOUN p8418k7419w 18 12 of of ADP p8418k7419w 18 13 5 5 NUM p8418k7419w 18 14 alpha alpha NOUN p8418k7419w 18 15 reductase reductase NOUN p8418k7419w 18 16 , , PUNCT p8418k7419w 18 17 suggests suggest VERB p8418k7419w 18 18 that that SCONJ p8418k7419w 18 19 it it PRON p8418k7419w 18 20 may may AUX p8418k7419w 18 21 be be AUX p8418k7419w 18 22 involved involve VERB p8418k7419w 18 23 in in ADP p8418k7419w 18 24 the the DET p8418k7419w 18 25 synthesis synthesis NOUN p8418k7419w 18 26 of of ADP p8418k7419w 18 27 5α 5α NUM p8418k7419w 18 28 ; ; PUNCT p8418k7419w 18 29 dht dht VERB p8418k7419w 18 30 in in ADP p8418k7419w 18 31 the the DET p8418k7419w 18 32 brain brain NOUN p8418k7419w 18 33 , , PUNCT p8418k7419w 18 34 apart apart ADV p8418k7419w 18 35 from from ADP p8418k7419w 18 36 peripheral peripheral ADJ p8418k7419w 18 37 androgenic androgenic NOUN p8418k7419w 18 38 targets target NOUN p8418k7419w 18 39 . . PUNCT