id sid tid token lemma pos p8418k74025 1 1 malaria malaria NOUN p8418k74025 1 2 is be AUX p8418k74025 1 3 a a DET p8418k74025 1 4 disease disease NOUN p8418k74025 1 5 that that PRON p8418k74025 1 6 affects affect VERB p8418k74025 1 7 the the DET p8418k74025 1 8 tropical tropical ADJ p8418k74025 1 9 areas area NOUN p8418k74025 1 10 of of ADP p8418k74025 1 11 the the DET p8418k74025 1 12 world world NOUN p8418k74025 1 13 , , PUNCT p8418k74025 1 14 killing kill VERB p8418k74025 1 15 1 1 NUM p8418k74025 1 16 - - SYM p8418k74025 1 17 2 2 NUM p8418k74025 1 18 million million NUM p8418k74025 1 19 people people NOUN p8418k74025 1 20 every every DET p8418k74025 1 21 year year NOUN p8418k74025 1 22 , , PUNCT p8418k74025 1 23 particularly particularly ADV p8418k74025 1 24 in in ADP p8418k74025 1 25 africa africa PROPN p8418k74025 1 26 . . PUNCT p8418k74025 2 1 in in ADP p8418k74025 2 2 order order NOUN p8418k74025 2 3 to to PART p8418k74025 2 4 complete complete VERB p8418k74025 2 5 its its PRON p8418k74025 2 6 life life NOUN p8418k74025 2 7 cycle cycle NOUN p8418k74025 2 8 , , PUNCT p8418k74025 2 9 plasmodium plasmodium NOUN p8418k74025 2 10 has have VERB p8418k74025 2 11 to to PART p8418k74025 2 12 reproduce reproduce VERB p8418k74025 2 13 asexually asexually ADV p8418k74025 2 14 in in ADP p8418k74025 2 15 the the DET p8418k74025 2 16 vertebrate vertebrate ADJ p8418k74025 2 17 erythrocytes erythrocyte NOUN p8418k74025 2 18 and and CCONJ p8418k74025 2 19 sexually sexually ADV p8418k74025 2 20 in in ADP p8418k74025 2 21 an an DET p8418k74025 2 22 anopheles anophele NOUN p8418k74025 2 23 vector vector NOUN p8418k74025 2 24 . . PUNCT p8418k74025 3 1 the the DET p8418k74025 3 2 invasion invasion NOUN p8418k74025 3 3 of of ADP p8418k74025 3 4 host host NOUN p8418k74025 3 5 cells cell NOUN p8418k74025 3 6 is be AUX p8418k74025 3 7 an an DET p8418k74025 3 8 essential essential ADJ p8418k74025 3 9 process process NOUN p8418k74025 3 10 in in ADP p8418k74025 3 11 the the DET p8418k74025 3 12 life life NOUN p8418k74025 3 13 cycle cycle NOUN p8418k74025 3 14 and and CCONJ p8418k74025 3 15 it it PRON p8418k74025 3 16 requires require VERB p8418k74025 3 17 parasite parasite NOUN p8418k74025 3 18 ligands ligand NOUN p8418k74025 3 19 and and CCONJ p8418k74025 3 20 host host NOUN p8418k74025 3 21 cell cell NOUN p8418k74025 3 22 receptors receptor NOUN p8418k74025 3 23 . . PUNCT p8418k74025 4 1 two two NUM p8418k74025 4 2 invasive invasive ADJ p8418k74025 4 3 stages stage NOUN p8418k74025 4 4 essential essential ADJ p8418k74025 4 5 for for ADP p8418k74025 4 6 the the DET p8418k74025 4 7 completion completion NOUN p8418k74025 4 8 of of ADP p8418k74025 4 9 the the DET p8418k74025 4 10 life life NOUN p8418k74025 4 11 cycle cycle NOUN p8418k74025 4 12 are be AUX p8418k74025 4 13 the the DET p8418k74025 4 14 merozoites merozoite NOUN p8418k74025 4 15 that that PRON p8418k74025 4 16 invade invade VERB p8418k74025 4 17 the the DET p8418k74025 4 18 red red ADJ p8418k74025 4 19 blood blood NOUN p8418k74025 4 20 cells cell NOUN p8418k74025 4 21 and and CCONJ p8418k74025 4 22 the the DET p8418k74025 4 23 sporozoites sporozoite NOUN p8418k74025 4 24 that that PRON p8418k74025 4 25 invade invade VERB p8418k74025 4 26 the the DET p8418k74025 4 27 mosquito mosquito NOUN p8418k74025 4 28 salivary salivary NOUN p8418k74025 4 29 glands gland NOUN p8418k74025 4 30 and and CCONJ p8418k74025 4 31 the the DET p8418k74025 4 32 vertebrate vertebrate ADJ p8418k74025 4 33 liver liver NOUN p8418k74025 4 34 cells cell NOUN p8418k74025 4 35 . . PUNCT p8418k74025 5 1 maebl maebl PROPN p8418k74025 5 2 is be AUX p8418k74025 5 3 a a DET p8418k74025 5 4 homologue homologue NOUN p8418k74025 5 5 of of ADP p8418k74025 5 6 the the DET p8418k74025 5 7 transmembrane transmembrane ADJ p8418k74025 5 8 erythrocyte erythrocyte NOUN p8418k74025 5 9 binding bind VERB p8418k74025 5 10 proteins protein NOUN p8418k74025 5 11 ( ( PUNCT p8418k74025 5 12 ebp ebp PROPN p8418k74025 5 13 ) ) PUNCT p8418k74025 5 14 ligands ligand NOUN p8418k74025 5 15 , , PUNCT p8418k74025 5 16 first first ADV p8418k74025 5 17 described describe VERB p8418k74025 5 18 in in ADP p8418k74025 5 19 erythrocytic erythrocytic ADJ p8418k74025 5 20 stages stage NOUN p8418k74025 5 21 . . PUNCT p8418k74025 6 1 it it PRON p8418k74025 6 2 is be AUX p8418k74025 6 3 abundantly abundantly ADV p8418k74025 6 4 expressed express VERB p8418k74025 6 5 in in ADP p8418k74025 6 6 midgut midgut NOUN p8418k74025 6 7 sporozoites sporozoite NOUN p8418k74025 6 8 and and CCONJ p8418k74025 6 9 was be AUX p8418k74025 6 10 found find VERB p8418k74025 6 11 to to PART p8418k74025 6 12 be be AUX p8418k74025 6 13 essential essential ADJ p8418k74025 6 14 for for ADP p8418k74025 6 15 the the DET p8418k74025 6 16 invasion invasion NOUN p8418k74025 6 17 of of ADP p8418k74025 6 18 anopheles anophele NOUN p8418k74025 6 19 salivary salivary NOUN p8418k74025 6 20 glands gland NOUN p8418k74025 6 21 in in ADP p8418k74025 6 22 plasmodium plasmodium NOUN p8418k74025 6 23 berghei berghei NOUN p8418k74025 6 24 . . PUNCT p8418k74025 7 1 alternative alternative ADJ p8418k74025 7 2 splicing splicing NOUN p8418k74025 7 3 generates generate VERB p8418k74025 7 4 different different ADJ p8418k74025 7 5 maebl maebl NOUN p8418k74025 7 6 isoforms isoform NOUN p8418k74025 7 7 and and CCONJ p8418k74025 7 8 so so ADV p8418k74025 7 9 it it PRON p8418k74025 7 10 is be AUX p8418k74025 7 11 unclear unclear ADJ p8418k74025 7 12 what what DET p8418k74025 7 13 form form NOUN p8418k74025 7 14 is be AUX p8418k74025 7 15 functionally functionally ADV p8418k74025 7 16 essential essential ADJ p8418k74025 7 17 . . PUNCT p8418k74025 8 1 we we PRON p8418k74025 8 2 examined examine VERB p8418k74025 8 3 the the DET p8418k74025 8 4 function function NOUN p8418k74025 8 5 of of ADP p8418k74025 8 6 plasmodium plasmodium NOUN p8418k74025 8 7 falciparum falciparum PROPN p8418k74025 8 8 maebl maebl PROPN p8418k74025 8 9 in in ADP p8418k74025 8 10 the the DET p8418k74025 8 11 erythrocytic erythrocytic ADJ p8418k74025 8 12 stages stage NOUN p8418k74025 8 13 by by ADP p8418k74025 8 14 creating create VERB p8418k74025 8 15 knockouts knockout NOUN p8418k74025 8 16 in in ADP p8418k74025 8 17 w2mef w2mef PROPN p8418k74025 8 18 and and CCONJ p8418k74025 8 19 nf54 nf54 PROPN p8418k74025 8 20 parasites parasite NOUN p8418k74025 8 21 . . PUNCT p8418k74025 9 1 we we PRON p8418k74025 9 2 found find VERB p8418k74025 9 3 that that SCONJ p8418k74025 9 4 maebl maebl PROPN p8418k74025 9 5 is be AUX p8418k74025 9 6 not not PART p8418k74025 9 7 essential essential ADJ p8418k74025 9 8 in in ADP p8418k74025 9 9 erythrocytic erythrocytic ADJ p8418k74025 9 10 stages stage NOUN p8418k74025 9 11 but but CCONJ p8418k74025 9 12 it it PRON p8418k74025 9 13 may may AUX p8418k74025 9 14 have have VERB p8418k74025 9 15 a a DET p8418k74025 9 16 conditional conditional ADJ p8418k74025 9 17 role role NOUN p8418k74025 9 18 in in ADP p8418k74025 9 19 p. p. PROPN p8418k74025 10 1 falciparum falciparum PROPN p8418k74025 10 2 blood blood NOUN p8418k74025 10 3 - - PUNCT p8418k74025 10 4 stage stage NOUN p8418k74025 10 5 growth growth NOUN p8418k74025 10 6 . . PUNCT p8418k74025 11 1 therefore therefore ADV p8418k74025 11 2 , , PUNCT p8418k74025 11 3 we we PRON p8418k74025 11 4 investigated investigate VERB p8418k74025 11 5 the the DET p8418k74025 11 6 function function NOUN p8418k74025 11 7 of of ADP p8418k74025 11 8 p. p. PROPN p8418k74025 11 9 falciparum falciparum PROPN p8418k74025 11 10 maebl maebl PROPN p8418k74025 11 11 in in ADP p8418k74025 11 12 the the DET p8418k74025 11 13 invasion invasion NOUN p8418k74025 11 14 of of ADP p8418k74025 11 15 salivary salivary ADJ p8418k74025 11 16 glands gland NOUN p8418k74025 11 17 . . PUNCT p8418k74025 12 1 using use VERB p8418k74025 12 2 p. p. NOUN p8418k74025 12 3 falciparum falciparum NOUN p8418k74025 12 4 nf54 nf54 PROPN p8418k74025 12 5 maebl maebl NOUN p8418k74025 12 6 knock knock VERB p8418k74025 12 7 outs out NOUN p8418k74025 12 8 , , PUNCT p8418k74025 12 9 we we PRON p8418k74025 12 10 confirmed confirm VERB p8418k74025 12 11 that that SCONJ p8418k74025 12 12 maebl maebl PROPN p8418k74025 12 13 is be AUX p8418k74025 12 14 essential essential ADJ p8418k74025 12 15 for for ADP p8418k74025 12 16 the the DET p8418k74025 12 17 invasion invasion NOUN p8418k74025 12 18 of of ADP p8418k74025 12 19 salivary salivary ADJ p8418k74025 12 20 glands gland NOUN p8418k74025 12 21 . . PUNCT p8418k74025 13 1 to to PART p8418k74025 13 2 identify identify VERB p8418k74025 13 3 the the DET p8418k74025 13 4 maebl maebl PROPN p8418k74025 13 5 isoform isoform PROPN p8418k74025 13 6 required require VERB p8418k74025 13 7 for for ADP p8418k74025 13 8 p. p. PROPN p8418k74025 13 9 falciparum falciparum NOUN p8418k74025 13 10 ( ( PUNCT p8418k74025 13 11 nf54 nf54 PROPN p8418k74025 13 12 ) ) PUNCT p8418k74025 13 13 sporozoite sporozoite NOUN p8418k74025 13 14 invasion invasion NOUN p8418k74025 13 15 of of ADP p8418k74025 13 16 salivary salivary ADJ p8418k74025 13 17 glands gland NOUN p8418k74025 13 18 , , PUNCT p8418k74025 13 19 we we PRON p8418k74025 13 20 created create VERB p8418k74025 13 21 knockout knockout NOUN p8418k74025 13 22 and and CCONJ p8418k74025 13 23 allelic allelic NOUN p8418k74025 13 24 replacements replacement NOUN p8418k74025 13 25 each each PRON p8418k74025 13 26 carrying carry VERB p8418k74025 13 27 cds cd NOUN p8418k74025 13 28 of of ADP p8418k74025 13 29 one one NUM p8418k74025 13 30 of of ADP p8418k74025 13 31 the the DET p8418k74025 13 32 major major ADJ p8418k74025 13 33 maebl maebl NOUN p8418k74025 13 34 isoforms isoform NOUN p8418k74025 13 35 . . PUNCT p8418k74025 14 1 only only ADV p8418k74025 14 2 the the DET p8418k74025 14 3 transmembrane transmembrane ADJ p8418k74025 14 4 form form NOUN p8418k74025 14 5 of of ADP p8418k74025 14 6 maebl maebl PROPN p8418k74025 14 7 is be AUX p8418k74025 14 8 essential essential ADJ p8418k74025 14 9 and and CCONJ p8418k74025 14 10 is be AUX p8418k74025 14 11 the the DET p8418k74025 14 12 first first ADJ p8418k74025 14 13 p. p. NOUN p8418k74025 14 14 falciparum falciparum PROPN p8418k74025 14 15 ligand ligand NOUN p8418k74025 14 16 validated validate VERB p8418k74025 14 17 as as ADP p8418k74025 14 18 essential essential ADJ p8418k74025 14 19 for for ADP p8418k74025 14 20 invasion invasion NOUN p8418k74025 14 21 of of ADP p8418k74025 14 22 anopheles anophele NOUN p8418k74025 14 23 salivary salivary NOUN p8418k74025 14 24 glands gland NOUN p8418k74025 14 25 . . PUNCT p8418k74025 15 1 understanding understand VERB p8418k74025 15 2 what what PRON p8418k74025 15 3 p. p. NOUN p8418k74025 15 4 falciparum falciparum NOUN p8418k74025 15 5 sporozoite sporozoite NOUN p8418k74025 15 6 ligands ligand NOUN p8418k74025 15 7 are be AUX p8418k74025 15 8 critical critical ADJ p8418k74025 15 9 for for ADP p8418k74025 15 10 mosquito mosquito PROPN p8418k74025 15 11 transmission transmission NOUN p8418k74025 15 12 will will AUX p8418k74025 15 13 help help VERB p8418k74025 15 14 validate validate VERB p8418k74025 15 15 targets target NOUN p8418k74025 15 16 for for ADP p8418k74025 15 17 vector vector NOUN p8418k74025 15 18 - - PUNCT p8418k74025 15 19 based base VERB p8418k74025 15 20 transmission transmission NOUN p8418k74025 15 21 - - PUNCT p8418k74025 15 22 blocking block VERB p8418k74025 15 23 strategies strategy NOUN p8418k74025 15 24 . . PUNCT