id	sid	tid	token	lemma	pos
nk322b91t43	1	1	epithelial	epithelial	ADJ
nk322b91t43	1	2	cancer	cancer	NOUN
nk322b91t43	1	3	progression	progression	NOUN
nk322b91t43	1	4	is	be	AUX
nk322b91t43	1	5	a	a	DET
nk322b91t43	1	6	consequence	consequence	NOUN
nk322b91t43	1	7	of	of	ADP
nk322b91t43	1	8	deregulation	deregulation	NOUN
nk322b91t43	1	9	of	of	ADP
nk322b91t43	1	10	a	a	DET
nk322b91t43	1	11	number	number	NOUN
nk322b91t43	1	12	of	of	ADP
nk322b91t43	1	13	cellular	cellular	ADJ
nk322b91t43	1	14	processes	process	NOUN
nk322b91t43	1	15	,	,	PUNCT
nk322b91t43	1	16	and	and	CCONJ
nk322b91t43	1	17	is	be	AUX
nk322b91t43	1	18	accompanied	accompany	VERB
nk322b91t43	1	19	by	by	ADP
nk322b91t43	1	20	the	the	DET
nk322b91t43	1	21	perturbation	perturbation	NOUN
nk322b91t43	1	22	of	of	ADP
nk322b91t43	1	23	epithelial	epithelial	ADJ
nk322b91t43	1	24	glandular	glandular	ADJ
nk322b91t43	1	25	architecture	architecture	NOUN
nk322b91t43	1	26	.	.	PUNCT
nk322b91t43	2	1	the	the	DET
nk322b91t43	2	2	breakdown	breakdown	NOUN
nk322b91t43	2	3	of	of	ADP
nk322b91t43	2	4	adhesive	adhesive	ADJ
nk322b91t43	2	5	contacts	contact	NOUN
nk322b91t43	2	6	,	,	PUNCT
nk322b91t43	2	7	internalization	internalization	NOUN
nk322b91t43	2	8	of	of	ADP
nk322b91t43	2	9	cell	cell	NOUN
nk322b91t43	2	10	-	-	PUNCT
nk322b91t43	2	11	surface	surface	NOUN
nk322b91t43	2	12	proteins	protein	NOUN
nk322b91t43	2	13	,	,	PUNCT
nk322b91t43	2	14	recycling	recycle	VERB
nk322b91t43	2	15	of	of	ADP
nk322b91t43	2	16	cargo	cargo	NOUN
nk322b91t43	2	17	back	back	ADV
nk322b91t43	2	18	to	to	ADP
nk322b91t43	2	19	the	the	DET
nk322b91t43	2	20	plasma	plasma	NOUN
nk322b91t43	2	21	membrane	membrane	NOUN
nk322b91t43	2	22	,	,	PUNCT
nk322b91t43	2	23	and	and	CCONJ
nk322b91t43	2	24	intracellular	intracellular	ADJ
nk322b91t43	2	25	signaling	signaling	NOUN
nk322b91t43	2	26	are	be	AUX
nk322b91t43	2	27	all	all	ADV
nk322b91t43	2	28	events	event	NOUN
nk322b91t43	2	29	that	that	PRON
nk322b91t43	2	30	are	be	AUX
nk322b91t43	2	31	derailed	derail	VERB
nk322b91t43	2	32	during	during	ADP
nk322b91t43	2	33	epithelial	epithelial	ADJ
nk322b91t43	2	34	glandular	glandular	ADJ
nk322b91t43	2	35	disruption	disruption	NOUN
nk322b91t43	2	36	.	.	PUNCT
nk322b91t43	3	1	multiple	multiple	ADJ
nk322b91t43	3	2	platforms	platform	NOUN
nk322b91t43	3	3	have	have	AUX
nk322b91t43	3	4	emerged	emerge	VERB
nk322b91t43	3	5	that	that	PRON
nk322b91t43	3	6	enable	enable	VERB
nk322b91t43	3	7	the	the	DET
nk322b91t43	3	8	study	study	NOUN
nk322b91t43	3	9	of	of	ADP
nk322b91t43	3	10	cellular	cellular	ADJ
nk322b91t43	3	11	events	event	NOUN
nk322b91t43	3	12	preceding	precede	VERB
nk322b91t43	3	13	and	and	CCONJ
nk322b91t43	3	14	contributing	contribute	VERB
nk322b91t43	3	15	to	to	ADP
nk322b91t43	3	16	glandular	glandular	ADJ
nk322b91t43	3	17	disruption	disruption	NOUN
nk322b91t43	3	18	,	,	PUNCT
nk322b91t43	3	19	as	as	SCONJ
nk322b91t43	3	20	it	it	PRON
nk322b91t43	3	21	pertains	pertain	VERB
nk322b91t43	3	22	to	to	ADP
nk322b91t43	3	23	early	early	ADJ
nk322b91t43	3	24	epithelial	epithelial	ADJ
nk322b91t43	3	25	tumor	tumor	NOUN
nk322b91t43	3	26	progression	progression	NOUN
nk322b91t43	3	27	.	.	PUNCT
nk322b91t43	4	1	while	while	SCONJ
nk322b91t43	4	2	investigations	investigation	NOUN
nk322b91t43	4	3	of	of	ADP
nk322b91t43	4	4	monolayers	monolayer	NOUN
nk322b91t43	4	5	provide	provide	VERB
nk322b91t43	4	6	insight	insight	NOUN
nk322b91t43	4	7	into	into	ADP
nk322b91t43	4	8	interactions	interaction	NOUN
nk322b91t43	4	9	between	between	ADP
nk322b91t43	4	10	cells	cell	NOUN
nk322b91t43	4	11	,	,	PUNCT
nk322b91t43	4	12	the	the	DET
nk322b91t43	4	13	3d	3d	NOUN
nk322b91t43	4	14	morphogenesis	morphogenesis	NOUN
nk322b91t43	4	15	culture	culture	NOUN
nk322b91t43	4	16	system	system	NOUN
nk322b91t43	4	17	allows	allow	VERB
nk322b91t43	4	18	for	for	ADP
nk322b91t43	4	19	further	further	ADJ
nk322b91t43	4	20	analysis	analysis	NOUN
nk322b91t43	4	21	of	of	ADP
nk322b91t43	4	22	hyperactivated	hyperactivate	VERB
nk322b91t43	4	23	cellular	cellular	ADJ
nk322b91t43	4	24	signaling	signaling	NOUN
nk322b91t43	4	25	and	and	CCONJ
nk322b91t43	4	26	its	its	PRON
nk322b91t43	4	27	effects	effect	NOUN
nk322b91t43	4	28	on	on	ADP
nk322b91t43	4	29	acinar	acinar	PROPN
nk322b91t43	4	30	structure	structure	NOUN
nk322b91t43	4	31	development	development	NOUN
nk322b91t43	4	32	,	,	PUNCT
nk322b91t43	4	33	reminiscent	reminiscent	ADJ
nk322b91t43	4	34	of	of	ADP
nk322b91t43	4	35	glandular	glandular	ADJ
nk322b91t43	4	36	remodeling	remodeling	NOUN
nk322b91t43	4	37	during	during	ADP
nk322b91t43	4	38	epithelial	epithelial	ADJ
nk322b91t43	4	39	cancer	cancer	NOUN
nk322b91t43	4	40	progression	progression	NOUN
nk322b91t43	4	41	.	.	PUNCT
nk322b91t43	5	1	ultimately	ultimately	ADV
nk322b91t43	5	2	,	,	PUNCT
nk322b91t43	5	3	the	the	DET
nk322b91t43	5	4	studies	study	NOUN
nk322b91t43	5	5	made	make	VERB
nk322b91t43	5	6	in	in	ADP
nk322b91t43	5	7	vitro	vitro	X
nk322b91t43	5	8	are	be	AUX
nk322b91t43	5	9	validated	validate	VERB
nk322b91t43	5	10	with	with	ADP
nk322b91t43	5	11	the	the	DET
nk322b91t43	5	12	use	use	NOUN
nk322b91t43	5	13	of	of	ADP
nk322b91t43	5	14	mouse	mouse	NOUN
nk322b91t43	5	15	models	model	NOUN
nk322b91t43	5	16	to	to	PART
nk322b91t43	5	17	demonstrate	demonstrate	VERB
nk322b91t43	5	18	the	the	DET
nk322b91t43	5	19	role	role	NOUN
nk322b91t43	5	20	of	of	ADP
nk322b91t43	5	21	key	key	ADJ
nk322b91t43	5	22	signaling	signal	VERB
nk322b91t43	5	23	cascades	cascade	NOUN
nk322b91t43	5	24	in	in	ADP
nk322b91t43	5	25	tumor	tumor	NOUN
nk322b91t43	5	26	development.this	development.this	NOUN
nk322b91t43	5	27	dissertation	dissertation	NOUN
nk322b91t43	5	28	contributes	contribute	VERB
nk322b91t43	5	29	to	to	ADP
nk322b91t43	5	30	the	the	DET
nk322b91t43	5	31	understanding	understanding	NOUN
nk322b91t43	5	32	of	of	ADP
nk322b91t43	5	33	epithelial	epithelial	ADJ
nk322b91t43	5	34	glandular	glandular	ADJ
nk322b91t43	5	35	morphogenesis	morphogenesis	NOUN
nk322b91t43	5	36	by	by	ADP
nk322b91t43	5	37	utilizing	utilize	VERB
nk322b91t43	5	38	monolayers	monolayer	NOUN
nk322b91t43	5	39	,	,	PUNCT
nk322b91t43	5	40	3d	3d	DET
nk322b91t43	5	41	culture	culture	NOUN
nk322b91t43	5	42	systems	system	NOUN
nk322b91t43	5	43	,	,	PUNCT
nk322b91t43	5	44	and	and	CCONJ
nk322b91t43	5	45	a	a	DET
nk322b91t43	5	46	mouse	mouse	NOUN
nk322b91t43	5	47	model	model	NOUN
nk322b91t43	5	48	of	of	ADP
nk322b91t43	5	49	mammary	mammary	ADJ
nk322b91t43	5	50	ductal	ductal	NOUN
nk322b91t43	5	51	carcinoma	carcinoma	NOUN
nk322b91t43	5	52	in	in	ADP
nk322b91t43	5	53	situ	situ	PROPN
nk322b91t43	5	54	.	.	PUNCT
nk322b91t43	6	1	in	in	ADP
nk322b91t43	6	2	response	response	NOUN
nk322b91t43	6	3	to	to	ADP
nk322b91t43	6	4	chronic	chronic	ADJ
nk322b91t43	6	5	wnt	wnt	PROPN
nk322b91t43	6	6	stimulation	stimulation	NOUN
nk322b91t43	6	7	,	,	PUNCT
nk322b91t43	6	8	an	an	DET
nk322b91t43	6	9	observed	observed	ADJ
nk322b91t43	6	10	characteristic	characteristic	NOUN
nk322b91t43	6	11	of	of	ADP
nk322b91t43	6	12	some	some	DET
nk322b91t43	6	13	tumor	tumor	NOUN
nk322b91t43	6	14	microenvironments	microenvironment	NOUN
nk322b91t43	6	15	,	,	PUNCT
nk322b91t43	6	16	the	the	DET
nk322b91t43	6	17	small	small	ADJ
nk322b91t43	6	18	gtp	gtp	NOUN
nk322b91t43	6	19	-	-	PUNCT
nk322b91t43	6	20	binding	bind	VERB
nk322b91t43	6	21	protein	protein	NOUN
nk322b91t43	6	22	arf6	arf6	PROPN
nk322b91t43	6	23	,	,	PUNCT
nk322b91t43	6	24	promotes	promote	VERB
nk322b91t43	6	25	the	the	DET
nk322b91t43	6	26	internalization	internalization	NOUN
nk322b91t43	6	27	of	of	ADP
nk322b91t43	6	28	cell	cell	NOUN
nk322b91t43	6	29	surface	surface	NOUN
nk322b91t43	6	30	proteins	protein	NOUN
nk322b91t43	6	31	by	by	ADP
nk322b91t43	6	32	employing	employ	VERB
nk322b91t43	6	33	distinct	distinct	ADJ
nk322b91t43	6	34	endocytic	endocytic	ADJ
nk322b91t43	6	35	mechanisms	mechanism	NOUN
nk322b91t43	6	36	in	in	ADP
nk322b91t43	6	37	polarized	polarize	VERB
nk322b91t43	6	38	epithelial	epithelial	ADJ
nk322b91t43	6	39	cells	cell	NOUN
nk322b91t43	6	40	.	.	PUNCT
nk322b91t43	7	1	mcf10dcis.com	mcf10dcis.com	X
nk322b91t43	7	2	cells	cell	NOUN
nk322b91t43	7	3	were	be	AUX
nk322b91t43	7	4	used	use	VERB
nk322b91t43	7	5	to	to	PART
nk322b91t43	7	6	study	study	VERB
nk322b91t43	7	7	the	the	DET
nk322b91t43	7	8	role	role	NOUN
nk322b91t43	7	9	of	of	ADP
nk322b91t43	7	10	these	these	DET
nk322b91t43	7	11	pathways	pathway	NOUN
nk322b91t43	7	12	in	in	ADP
nk322b91t43	7	13	a	a	DET
nk322b91t43	7	14	model	model	NOUN
nk322b91t43	7	15	of	of	ADP
nk322b91t43	7	16	ductal	ductal	ADJ
nk322b91t43	7	17	carcinoma	carcinoma	NOUN
nk322b91t43	7	18	in	in	ADP
nk322b91t43	7	19	situ	situ	PROPN
nk322b91t43	7	20	(	(	PUNCT
nk322b91t43	7	21	dcis	dcis	PROPN
nk322b91t43	7	22	)	)	PUNCT
nk322b91t43	7	23	.	.	PUNCT
nk322b91t43	8	1	arf6	arf6	PROPN
nk322b91t43	8	2	knockdown	knockdown	NOUN
nk322b91t43	8	3	or	or	CCONJ
nk322b91t43	8	4	dominant	dominant	ADJ
nk322b91t43	8	5	inhibition	inhibition	NOUN
nk322b91t43	8	6	of	of	ADP
nk322b91t43	8	7	the	the	DET
nk322b91t43	8	8	protein	protein	NOUN
nk322b91t43	8	9	results	result	NOUN
nk322b91t43	8	10	in	in	ADP
nk322b91t43	8	11	striking	strike	VERB
nk322b91t43	8	12	alterations	alteration	NOUN
nk322b91t43	8	13	of	of	ADP
nk322b91t43	8	14	the	the	DET
nk322b91t43	8	15	dcis	dcis	PROPN
nk322b91t43	8	16	acinar	acinar	PROPN
nk322b91t43	8	17	phenotype	phenotype	PROPN
nk322b91t43	8	18	and	and	CCONJ
nk322b91t43	8	19	decreased	decrease	VERB
nk322b91t43	8	20	cell	cell	NOUN
nk322b91t43	8	21	proliferation	proliferation	NOUN
nk322b91t43	8	22	in	in	ADP
nk322b91t43	8	23	vitro	vitro	X
nk322b91t43	8	24	.	.	PUNCT
nk322b91t43	9	1	these	these	DET
nk322b91t43	9	2	defects	defect	NOUN
nk322b91t43	9	3	are	be	AUX
nk322b91t43	9	4	coupled	couple	VERB
nk322b91t43	9	5	with	with	ADP
nk322b91t43	9	6	a	a	DET
nk322b91t43	9	7	marked	marked	ADJ
nk322b91t43	9	8	perturbation	perturbation	NOUN
nk322b91t43	9	9	of	of	ADP
nk322b91t43	9	10	cargo	cargo	NOUN
nk322b91t43	9	11	recycling	recycling	NOUN
nk322b91t43	9	12	along	along	ADP
nk322b91t43	9	13	the	the	DET
nk322b91t43	9	14	endocytic	endocytic	ADJ
nk322b91t43	9	15	pathways	pathway	NOUN
nk322b91t43	9	16	.	.	PUNCT
nk322b91t43	10	1	finally	finally	ADV
nk322b91t43	10	2	,	,	PUNCT
nk322b91t43	10	3	in	in	ADP
nk322b91t43	10	4	a	a	DET
nk322b91t43	10	5	mouse	mouse	NOUN
nk322b91t43	10	6	mammary	mammary	ADJ
nk322b91t43	10	7	model	model	NOUN
nk322b91t43	10	8	of	of	ADP
nk322b91t43	10	9	dcis	dcis	PROPN
nk322b91t43	10	10	,	,	PUNCT
nk322b91t43	10	11	arf6	arf6	PROPN
nk322b91t43	10	12	depletion	depletion	NOUN
nk322b91t43	10	13	or	or	CCONJ
nk322b91t43	10	14	its	its	PRON
nk322b91t43	10	15	inhibition	inhibition	NOUN
nk322b91t43	10	16	results	result	NOUN
nk322b91t43	10	17	is	be	AUX
nk322b91t43	10	18	profound	profound	ADJ
nk322b91t43	10	19	changes	change	NOUN
nk322b91t43	10	20	to	to	ADP
nk322b91t43	10	21	the	the	DET
nk322b91t43	10	22	development	development	NOUN
nk322b91t43	10	23	and	and	CCONJ
nk322b91t43	10	24	progression	progression	NOUN
nk322b91t43	10	25	of	of	ADP
nk322b91t43	10	26	dcis	dcis	PROPN
nk322b91t43	10	27	with	with	ADP
nk322b91t43	10	28	pronounced	pronounced	ADJ
nk322b91t43	10	29	reduction	reduction	NOUN
nk322b91t43	10	30	in	in	ADP
nk322b91t43	10	31	tumor	tumor	NOUN
nk322b91t43	10	32	cell	cell	NOUN
nk322b91t43	10	33	invasion	invasion	NOUN
nk322b91t43	10	34	.	.	PUNCT
nk322b91t43	11	1	taken	take	VERB
nk322b91t43	11	2	together	together	ADV
nk322b91t43	11	3	our	our	PRON
nk322b91t43	11	4	studies	study	NOUN
nk322b91t43	11	5	suggest	suggest	VERB
nk322b91t43	11	6	a	a	DET
nk322b91t43	11	7	vital	vital	ADJ
nk322b91t43	11	8	role	role	NOUN
nk322b91t43	11	9	for	for	ADP
nk322b91t43	11	10	arf6	arf6	PROPN
nk322b91t43	11	11	signaling	signaling	NOUN
nk322b91t43	11	12	and	and	CCONJ
nk322b91t43	11	13	endocytic	endocytic	ADJ
nk322b91t43	11	14	recycling	recycling	NOUN
nk322b91t43	11	15	in	in	ADP
nk322b91t43	11	16	the	the	DET
nk322b91t43	11	17	onset	onset	NOUN
nk322b91t43	11	18	and	and	CCONJ
nk322b91t43	11	19	progression	progression	NOUN
nk322b91t43	11	20	of	of	ADP
nk322b91t43	11	21	mammary	mammary	ADJ
nk322b91t43	11	22	epithelial	epithelial	ADJ
nk322b91t43	11	23	glandular	glandular	ADJ
nk322b91t43	11	24	cancers	cancer	NOUN
nk322b91t43	11	25	.	.	PUNCT