id sid tid token lemma pos nk322b9123x 1 1 this this DET nk322b9123x 1 2 dissertation dissertation NOUN nk322b9123x 1 3 describes describe VERB nk322b9123x 1 4 three three NUM nk322b9123x 1 5 classes class NOUN nk322b9123x 1 6 of of ADP nk322b9123x 1 7 synthetic synthetic ADJ nk322b9123x 1 8 anion anion NOUN nk322b9123x 1 9 transporters transporter NOUN nk322b9123x 1 10 which which PRON nk322b9123x 1 11 facilitate facilitate VERB nk322b9123x 1 12 chloride chloride NOUN nk322b9123x 1 13 transport transport NOUN nk322b9123x 1 14 across across ADP nk322b9123x 1 15 vesicle vesicle NOUN nk322b9123x 1 16 and and CCONJ nk322b9123x 1 17 cell cell NOUN nk322b9123x 1 18 membranes membrane NOUN nk322b9123x 1 19 . . PUNCT nk322b9123x 2 1 fluorescent fluorescent NOUN nk322b9123x 2 2 and and CCONJ nk322b9123x 2 3 potentiometric potentiometric ADJ nk322b9123x 2 4 transport transport NOUN nk322b9123x 2 5 assays assay NOUN nk322b9123x 2 6 uncovered uncover VERB nk322b9123x 2 7 the the DET nk322b9123x 2 8 important important ADJ nk322b9123x 2 9 structural structural ADJ nk322b9123x 2 10 features feature NOUN nk322b9123x 2 11 that that PRON nk322b9123x 2 12 produce produce VERB nk322b9123x 2 13 high high ADJ nk322b9123x 2 14 transport transport NOUN nk322b9123x 2 15 rates rate NOUN nk322b9123x 2 16 , , PUNCT nk322b9123x 2 17 and and CCONJ nk322b9123x 2 18 the the DET nk322b9123x 2 19 effect effect NOUN nk322b9123x 2 20 of of ADP nk322b9123x 2 21 the the DET nk322b9123x 2 22 transporters transporter NOUN nk322b9123x 2 23 on on ADP nk322b9123x 2 24 cell cell NOUN nk322b9123x 2 25 functions function NOUN nk322b9123x 2 26 was be AUX nk322b9123x 2 27 also also ADV nk322b9123x 2 28 evaluated evaluate VERB nk322b9123x 2 29 . . PUNCT nk322b9123x 3 1 the the DET nk322b9123x 3 2 first first ADJ nk322b9123x 3 3 class class NOUN nk322b9123x 3 4 of of ADP nk322b9123x 3 5 transporters transporter NOUN nk322b9123x 3 6 is be AUX nk322b9123x 3 7 the the DET nk322b9123x 3 8 cholates cholate NOUN nk322b9123x 3 9 , , PUNCT nk322b9123x 3 10 which which PRON nk322b9123x 3 11 use use VERB nk322b9123x 3 12 a a DET nk322b9123x 3 13 mobile mobile ADJ nk322b9123x 3 14 carrier carrier NOUN nk322b9123x 3 15 mechanism mechanism NOUN nk322b9123x 3 16 to to PART nk322b9123x 3 17 transport transport VERB nk322b9123x 3 18 chloride chloride NOUN nk322b9123x 3 19 across across ADP nk322b9123x 3 20 membranes membrane NOUN nk322b9123x 3 21 via via ADP nk322b9123x 3 22 an an DET nk322b9123x 3 23 anion anion NOUN nk322b9123x 3 24 exchange exchange NOUN nk322b9123x 3 25 process process NOUN nk322b9123x 3 26 . . PUNCT nk322b9123x 4 1 as as ADP nk322b9123x 4 2 a a DET nk322b9123x 4 3 general general ADJ nk322b9123x 4 4 trend trend NOUN nk322b9123x 4 5 , , PUNCT nk322b9123x 4 6 the the DET nk322b9123x 4 7 better well ADJ nk322b9123x 4 8 anion anion NOUN nk322b9123x 4 9 binder binder NOUN nk322b9123x 4 10 is be AUX nk322b9123x 4 11 the the DET nk322b9123x 4 12 better well ADJ nk322b9123x 4 13 transporter transporter NOUN nk322b9123x 4 14 and and CCONJ nk322b9123x 4 15 that that SCONJ nk322b9123x 4 16 the the DET nk322b9123x 4 17 combination combination NOUN nk322b9123x 4 18 of of ADP nk322b9123x 4 19 a a DET nk322b9123x 4 20 lipophilic lipophilic ADJ nk322b9123x 4 21 backbone backbone NOUN nk322b9123x 4 22 with with ADP nk322b9123x 4 23 a a DET nk322b9123x 4 24 preorganized preorganize VERB nk322b9123x 4 25 binding bind VERB nk322b9123x 4 26 pocket pocket NOUN nk322b9123x 4 27 produces produce VERB nk322b9123x 4 28 excellent excellent ADJ nk322b9123x 4 29 chloride chloride NOUN nk322b9123x 4 30 transporters transporter NOUN nk322b9123x 4 31 with with ADP nk322b9123x 4 32 high high ADJ nk322b9123x 4 33 anion anion NOUN nk322b9123x 4 34 binding bind VERB nk322b9123x 4 35 affinity affinity NOUN nk322b9123x 4 36 and and CCONJ nk322b9123x 4 37 high high ADJ nk322b9123x 4 38 transport transport NOUN nk322b9123x 4 39 at at ADP nk322b9123x 4 40 low low ADJ nk322b9123x 4 41 cholate cholate NOUN nk322b9123x 4 42 concentration concentration NOUN nk322b9123x 4 43 . . PUNCT nk322b9123x 5 1 the the DET nk322b9123x 5 2 second second ADJ nk322b9123x 5 3 class class NOUN nk322b9123x 5 4 of of ADP nk322b9123x 5 5 transporters transporter NOUN nk322b9123x 5 6 is be AUX nk322b9123x 5 7 the the DET nk322b9123x 5 8 prodigiosin prodigiosin NOUN nk322b9123x 5 9 mimics mimic NOUN nk322b9123x 5 10 , , PUNCT nk322b9123x 5 11 consisting consist VERB nk322b9123x 5 12 of of ADP nk322b9123x 5 13 synthetic synthetic ADJ nk322b9123x 5 14 pyrrole pyrrole NOUN nk322b9123x 5 15 and and CCONJ nk322b9123x 5 16 pyridine pyridine NOUN nk322b9123x 5 17 transporters transporter NOUN nk322b9123x 5 18 . . PUNCT nk322b9123x 6 1 both both DET nk322b9123x 6 2 sets set NOUN nk322b9123x 6 3 of of ADP nk322b9123x 6 4 transporters transporter NOUN nk322b9123x 6 5 use use VERB nk322b9123x 6 6 a a DET nk322b9123x 6 7 mobile mobile ADJ nk322b9123x 6 8 carrier carrier NOUN nk322b9123x 6 9 mechanism mechanism NOUN nk322b9123x 6 10 to to PART nk322b9123x 6 11 promote promote VERB nk322b9123x 6 12 two two NUM nk322b9123x 6 13 transport transport NOUN nk322b9123x 6 14 processes process NOUN nk322b9123x 6 15 , , PUNCT nk322b9123x 6 16 anion anion NOUN nk322b9123x 6 17 exchange exchange NOUN nk322b9123x 6 18 and and CCONJ nk322b9123x 6 19 hcl hcl PROPN nk322b9123x 6 20 co co NOUN nk322b9123x 6 21 - - NOUN nk322b9123x 6 22 transport transport NOUN nk322b9123x 6 23 , , PUNCT nk322b9123x 6 24 attributed attribute VERB nk322b9123x 6 25 to to ADP nk322b9123x 6 26 the the DET nk322b9123x 6 27 ph ph PROPN nk322b9123x 6 28 sensitive sensitive ADJ nk322b9123x 6 29 imidazole imidazole PROPN nk322b9123x 6 30 substituent substituent NOUN nk322b9123x 6 31 . . PUNCT nk322b9123x 7 1 subtle subtle ADJ nk322b9123x 7 2 structural structural ADJ nk322b9123x 7 3 changes change NOUN nk322b9123x 7 4 greatly greatly ADV nk322b9123x 7 5 impact impact VERB nk322b9123x 7 6 the the DET nk322b9123x 7 7 transporter transporter NOUN nk322b9123x 7 8 conformation conformation NOUN nk322b9123x 7 9 and and CCONJ nk322b9123x 7 10 lipophilicity lipophilicity NOUN nk322b9123x 7 11 , , PUNCT nk322b9123x 7 12 which which PRON nk322b9123x 7 13 directly directly ADV nk322b9123x 7 14 alters alter VERB nk322b9123x 7 15 transport transport NOUN nk322b9123x 7 16 rates rate NOUN nk322b9123x 7 17 . . PUNCT nk322b9123x 8 1 the the DET nk322b9123x 8 2 third third ADJ nk322b9123x 8 3 class class NOUN nk322b9123x 8 4 of of ADP nk322b9123x 8 5 transporters transporter NOUN nk322b9123x 8 6 employs employ VERB nk322b9123x 8 7 a a DET nk322b9123x 8 8 synthetic synthetic ADJ nk322b9123x 8 9 phospholipid phospholipid NOUN nk322b9123x 8 10 that that PRON nk322b9123x 8 11 is be AUX nk322b9123x 8 12 functionalized functionalize VERB nk322b9123x 8 13 with with ADP nk322b9123x 8 14 an an DET nk322b9123x 8 15 anion anion NOUN nk322b9123x 8 16 binding bind VERB nk322b9123x 8 17 affinity affinity NOUN nk322b9123x 8 18 group group NOUN nk322b9123x 8 19 . . PUNCT nk322b9123x 9 1 mechanistic mechanistic ADJ nk322b9123x 9 2 studies study NOUN nk322b9123x 9 3 indicate indicate VERB nk322b9123x 9 4 that that SCONJ nk322b9123x 9 5 transport transport NOUN nk322b9123x 9 6 occurs occur VERB nk322b9123x 9 7 via via ADP nk322b9123x 9 8 a a DET nk322b9123x 9 9 novel novel ADJ nk322b9123x 9 10 anion anion NOUN nk322b9123x 9 11 relay relay NOUN nk322b9123x 9 12 mechanism mechanism NOUN nk322b9123x 9 13 , , PUNCT nk322b9123x 9 14 combining combine VERB nk322b9123x 9 15 the the DET nk322b9123x 9 16 anion anion NOUN nk322b9123x 9 17 selectivity selectivity NOUN nk322b9123x 9 18 of of ADP nk322b9123x 9 19 a a DET nk322b9123x 9 20 mobile mobile ADJ nk322b9123x 9 21 carrier carrier NOUN nk322b9123x 9 22 with with ADP nk322b9123x 9 23 the the DET nk322b9123x 9 24 membrane membrane NOUN nk322b9123x 9 25 spanning span VERB nk322b9123x 9 26 ability ability NOUN nk322b9123x 9 27 of of ADP nk322b9123x 9 28 channels channel NOUN nk322b9123x 9 29 . . PUNCT nk322b9123x 10 1 the the DET nk322b9123x 10 2 kinetically kinetically ADV nk322b9123x 10 3 active active ADJ nk322b9123x 10 4 aggregate aggregate ADJ nk322b9123x 10 5 complex complex NOUN nk322b9123x 10 6 is be AUX nk322b9123x 10 7 composed compose VERB nk322b9123x 10 8 of of ADP nk322b9123x 10 9 two two NUM nk322b9123x 10 10 or or CCONJ nk322b9123x 10 11 four four NUM nk322b9123x 10 12 monomer monomer NOUN nk322b9123x 10 13 units unit NOUN nk322b9123x 10 14 , , PUNCT nk322b9123x 10 15 depending depend VERB nk322b9123x 10 16 on on ADP nk322b9123x 10 17 bilayer bilayer NOUN nk322b9123x 10 18 thickness thickness NOUN nk322b9123x 10 19 , , PUNCT nk322b9123x 10 20 and and CCONJ nk322b9123x 10 21 transport transport NOUN nk322b9123x 10 22 stops stop NOUN nk322b9123x 10 23 upon upon SCONJ nk322b9123x 10 24 reaching reach VERB nk322b9123x 10 25 a a DET nk322b9123x 10 26 threshold threshold ADJ nk322b9123x 10 27 bilayer bilayer NOUN nk322b9123x 10 28 thickness thickness NOUN nk322b9123x 10 29 . . PUNCT nk322b9123x 11 1 finally finally ADV nk322b9123x 11 2 , , PUNCT nk322b9123x 11 3 investigations investigation NOUN nk322b9123x 11 4 of of ADP nk322b9123x 11 5 transporter transporter NOUN nk322b9123x 11 6 function function NOUN nk322b9123x 11 7 in in ADP nk322b9123x 11 8 cells cell NOUN nk322b9123x 11 9 reveals reveal VERB nk322b9123x 11 10 that that SCONJ nk322b9123x 11 11 the the DET nk322b9123x 11 12 transporters transporter NOUN nk322b9123x 11 13 act act VERB nk322b9123x 11 14 on on ADP nk322b9123x 11 15 mitochondria mitochondria NOUN nk322b9123x 11 16 and and CCONJ nk322b9123x 11 17 late late ADJ nk322b9123x 11 18 endosomes endosome NOUN nk322b9123x 11 19 / / SYM nk322b9123x 11 20 lysosomes lysosome NOUN nk322b9123x 11 21 , , PUNCT nk322b9123x 11 22 depending depend VERB nk322b9123x 11 23 on on ADP nk322b9123x 11 24 their their PRON nk322b9123x 11 25 chloride chloride NOUN nk322b9123x 11 26 and and CCONJ nk322b9123x 11 27 hcl hcl PROPN nk322b9123x 11 28 transport transport NOUN nk322b9123x 11 29 ability ability NOUN nk322b9123x 11 30 , , PUNCT nk322b9123x 11 31 respectively respectively ADV nk322b9123x 11 32 . . PUNCT nk322b9123x 12 1 this this DET nk322b9123x 12 2 research research NOUN nk322b9123x 12 3 has have AUX nk322b9123x 12 4 improved improve VERB nk322b9123x 12 5 the the DET nk322b9123x 12 6 mechanistic mechanistic ADJ nk322b9123x 12 7 understanding understanding NOUN nk322b9123x 12 8 of of ADP nk322b9123x 12 9 three three NUM nk322b9123x 12 10 different different ADJ nk322b9123x 12 11 transporter transporter NOUN nk322b9123x 12 12 designs design NOUN nk322b9123x 12 13 and and CCONJ nk322b9123x 12 14 identified identify VERB nk322b9123x 12 15 their their PRON nk322b9123x 12 16 effects effect NOUN nk322b9123x 12 17 on on ADP nk322b9123x 12 18 cellular cellular ADJ nk322b9123x 12 19 function function NOUN nk322b9123x 12 20 , , PUNCT nk322b9123x 12 21 suggesting suggest VERB nk322b9123x 12 22 that that SCONJ nk322b9123x 12 23 they they PRON nk322b9123x 12 24 have have VERB nk322b9123x 12 25 potential potential ADJ nk322b9123x 12 26 applications application NOUN nk322b9123x 12 27 in in ADP nk322b9123x 12 28 cell cell NOUN nk322b9123x 12 29 biology biology NOUN nk322b9123x 12 30 research research NOUN nk322b9123x 12 31 . . PUNCT