id	sid	tid	token	lemma	pos
nc580k24g4v	1	1	multi	multi	NOUN
nc580k24g4v	1	2	-	-	NOUN
nc580k24g4v	1	3	specificity	specificity	NOUN
nc580k24g4v	1	4	is	be	AUX
nc580k24g4v	1	5	a	a	DET
nc580k24g4v	1	6	hallmark	hallmark	NOUN
nc580k24g4v	1	7	of	of	ADP
nc580k24g4v	1	8	t	t	NOUN
nc580k24g4v	1	9	cell	cell	NOUN
nc580k24g4v	1	10	receptor	receptor	NOUN
nc580k24g4v	1	11	(	(	PUNCT
nc580k24g4v	1	12	tcr	tcr	PROPN
nc580k24g4v	1	13	)	)	PUNCT
nc580k24g4v	1	14	recognition	recognition	NOUN
nc580k24g4v	1	15	,	,	PUNCT
nc580k24g4v	1	16	as	as	SCONJ
nc580k24g4v	1	17	a	a	DET
nc580k24g4v	1	18	high	high	ADJ
nc580k24g4v	1	19	volume	volume	NOUN
nc580k24g4v	1	20	of	of	ADP
nc580k24g4v	1	21	antigen	antigen	NOUN
nc580k24g4v	1	22	must	must	AUX
nc580k24g4v	1	23	be	be	AUX
nc580k24g4v	1	24	identified	identify	VERB
nc580k24g4v	1	25	by	by	ADP
nc580k24g4v	1	26	the	the	DET
nc580k24g4v	1	27	t	t	PROPN
nc580k24g4v	1	28	cell	cell	NOUN
nc580k24g4v	1	29	arm	arm	NOUN
nc580k24g4v	1	30	of	of	ADP
nc580k24g4v	1	31	the	the	DET
nc580k24g4v	1	32	immune	immune	ADJ
nc580k24g4v	1	33	system	system	NOUN
nc580k24g4v	1	34	.	.	PUNCT
nc580k24g4v	2	1	the	the	DET
nc580k24g4v	2	2	mechanism	mechanism	NOUN
nc580k24g4v	2	3	by	by	ADP
nc580k24g4v	2	4	which	which	PRON
nc580k24g4v	2	5	a	a	DET
nc580k24g4v	2	6	tcr	tcr	NOUN
nc580k24g4v	2	7	engages	engage	VERB
nc580k24g4v	2	8	a	a	DET
nc580k24g4v	2	9	potential	potential	ADJ
nc580k24g4v	2	10	ligand	ligand	NOUN
nc580k24g4v	2	11	and	and	CCONJ
nc580k24g4v	2	12	distinguishes	distinguish	VERB
nc580k24g4v	2	13	its	its	PRON
nc580k24g4v	2	14	composition	composition	NOUN
nc580k24g4v	2	15	as	as	ADP
nc580k24g4v	2	16	either	either	CCONJ
nc580k24g4v	2	17	foreign	foreign	ADJ
nc580k24g4v	2	18	or	or	CCONJ
nc580k24g4v	2	19	self	self	NOUN
nc580k24g4v	2	20	&	&	CCONJ
nc580k24g4v	2	21	ndash	ndash	NOUN
nc580k24g4v	2	22	;	;	PUNCT
nc580k24g4v	2	23	and	and	CCONJ
nc580k24g4v	2	24	doing	do	VERB
nc580k24g4v	2	25	this	this	PRON
nc580k24g4v	2	26	many	many	ADJ
nc580k24g4v	2	27	times	time	NOUN
nc580k24g4v	2	28	over	over	ADV
nc580k24g4v	2	29	with	with	ADP
nc580k24g4v	2	30	a	a	DET
nc580k24g4v	2	31	diverse	diverse	ADJ
nc580k24g4v	2	32	array	array	NOUN
nc580k24g4v	2	33	of	of	ADP
nc580k24g4v	2	34	ligands	ligand	NOUN
nc580k24g4v	2	35	&	&	CCONJ
nc580k24g4v	2	36	ndash	ndash	PROPN
nc580k24g4v	2	37	;	;	PUNCT
nc580k24g4v	2	38	is	be	AUX
nc580k24g4v	2	39	a	a	DET
nc580k24g4v	2	40	remarkable	remarkable	ADJ
nc580k24g4v	2	41	operation	operation	NOUN
nc580k24g4v	2	42	that	that	PRON
nc580k24g4v	2	43	remains	remain	VERB
nc580k24g4v	2	44	mechanistically	mechanistically	ADV
nc580k24g4v	2	45	ambiguous	ambiguous	ADJ
nc580k24g4v	2	46	.	.	PUNCT
nc580k24g4v	3	1	protein	protein	NOUN
nc580k24g4v	3	2	-	-	PUNCT
nc580k24g4v	3	3	protein	protein	NOUN
nc580k24g4v	3	4	interactions	interaction	NOUN
nc580k24g4v	3	5	have	have	AUX
nc580k24g4v	3	6	been	be	AUX
nc580k24g4v	3	7	characterized	characterize	VERB
nc580k24g4v	3	8	by	by	ADP
nc580k24g4v	3	9	a	a	DET
nc580k24g4v	3	10	wide	wide	ADJ
nc580k24g4v	3	11	variety	variety	NOUN
nc580k24g4v	3	12	of	of	ADP
nc580k24g4v	3	13	biophysical	biophysical	ADJ
nc580k24g4v	3	14	and	and	CCONJ
nc580k24g4v	3	15	structural	structural	ADJ
nc580k24g4v	3	16	methods	method	NOUN
nc580k24g4v	3	17	,	,	PUNCT
nc580k24g4v	3	18	which	which	PRON
nc580k24g4v	3	19	have	have	AUX
nc580k24g4v	3	20	resolved	resolve	VERB
nc580k24g4v	3	21	many	many	ADJ
nc580k24g4v	3	22	key	key	ADJ
nc580k24g4v	3	23	attributes	attribute	NOUN
nc580k24g4v	3	24	of	of	ADP
nc580k24g4v	3	25	the	the	DET
nc580k24g4v	3	26	interaction	interaction	NOUN
nc580k24g4v	3	27	process	process	NOUN
nc580k24g4v	3	28	.	.	PUNCT
nc580k24g4v	4	1	this	this	PRON
nc580k24g4v	4	2	is	be	AUX
nc580k24g4v	4	3	certainly	certainly	ADV
nc580k24g4v	4	4	the	the	DET
nc580k24g4v	4	5	case	case	NOUN
nc580k24g4v	4	6	of	of	ADP
nc580k24g4v	4	7	the	the	DET
nc580k24g4v	4	8	tcrs	tcr	NOUN
nc580k24g4v	4	9	and	and	CCONJ
nc580k24g4v	4	10	their	their	PRON
nc580k24g4v	4	11	antigen	antigen	NOUN
nc580k24g4v	4	12	,	,	PUNCT
nc580k24g4v	4	13	peptides	peptide	NOUN
nc580k24g4v	4	14	bound	bind	VERB
nc580k24g4v	4	15	to	to	ADP
nc580k24g4v	4	16	cell	cell	NOUN
nc580k24g4v	4	17	-	-	PUNCT
nc580k24g4v	4	18	associated	associate	VERB
nc580k24g4v	4	19	major	major	ADJ
nc580k24g4v	4	20	histocompatibility	histocompatibility	NOUN
nc580k24g4v	4	21	complex	complex	NOUN
nc580k24g4v	4	22	(	(	PUNCT
nc580k24g4v	4	23	pmhc	pmhc	NOUN
nc580k24g4v	4	24	)	)	PUNCT
nc580k24g4v	4	25	.	.	PUNCT
nc580k24g4v	5	1	however	however	ADV
nc580k24g4v	5	2	,	,	PUNCT
nc580k24g4v	5	3	holes	hole	NOUN
nc580k24g4v	5	4	in	in	ADP
nc580k24g4v	5	5	the	the	DET
nc580k24g4v	5	6	arguments	argument	NOUN
nc580k24g4v	5	7	for	for	ADP
nc580k24g4v	5	8	how	how	SCONJ
nc580k24g4v	5	9	the	the	DET
nc580k24g4v	5	10	recognition	recognition	NOUN
nc580k24g4v	5	11	process	process	NOUN
nc580k24g4v	5	12	is	be	AUX
nc580k24g4v	5	13	carried	carry	VERB
nc580k24g4v	5	14	out	out	ADP
nc580k24g4v	5	15	are	be	AUX
nc580k24g4v	5	16	extremely	extremely	ADV
nc580k24g4v	5	17	confounding	confounding	ADJ
nc580k24g4v	5	18	,	,	PUNCT
nc580k24g4v	5	19	calling	call	VERB
nc580k24g4v	5	20	for	for	ADP
nc580k24g4v	5	21	new	new	ADJ
nc580k24g4v	5	22	approaches	approach	NOUN
nc580k24g4v	5	23	to	to	PART
nc580k24g4v	5	24	more	more	ADV
nc580k24g4v	5	25	fully	fully	ADV
nc580k24g4v	5	26	characterize	characterize	VERB
nc580k24g4v	5	27	the	the	DET
nc580k24g4v	5	28	mechanism	mechanism	NOUN
nc580k24g4v	5	29	of	of	ADP
nc580k24g4v	5	30	tcr	tcr	PROPN
nc580k24g4v	5	31	-	-	PUNCT
nc580k24g4v	5	32	pmhc	pmhc	PROPN
nc580k24g4v	5	33	recognition	recognition	NOUN
nc580k24g4v	5	34	.	.	PUNCT
nc580k24g4v	6	1	it	it	PRON
nc580k24g4v	6	2	has	have	AUX
nc580k24g4v	6	3	been	be	AUX
nc580k24g4v	6	4	well	well	ADV
nc580k24g4v	6	5	-	-	PUNCT
nc580k24g4v	6	6	established	establish	VERB
nc580k24g4v	6	7	that	that	SCONJ
nc580k24g4v	6	8	protein	protein	NOUN
nc580k24g4v	6	9	function	function	NOUN
nc580k24g4v	6	10	is	be	AUX
nc580k24g4v	6	11	heavily	heavily	ADV
nc580k24g4v	6	12	influenced	influence	VERB
nc580k24g4v	6	13	by	by	ADP
nc580k24g4v	6	14	the	the	DET
nc580k24g4v	6	15	dynamic	dynamic	ADJ
nc580k24g4v	6	16	properties	property	NOUN
nc580k24g4v	6	17	of	of	ADP
nc580k24g4v	6	18	a	a	DET
nc580k24g4v	6	19	protein	protein	NOUN
nc580k24g4v	6	20	.	.	PUNCT
nc580k24g4v	7	1	conformational	conformational	ADJ
nc580k24g4v	7	2	diversity	diversity	NOUN
nc580k24g4v	7	3	of	of	ADP
nc580k24g4v	7	4	tcrs	tcr	NOUN
nc580k24g4v	7	5	has	have	AUX
nc580k24g4v	7	6	been	be	AUX
nc580k24g4v	7	7	revealed	reveal	VERB
nc580k24g4v	7	8	through	through	ADP
nc580k24g4v	7	9	crystallographic	crystallographic	ADJ
nc580k24g4v	7	10	and	and	CCONJ
nc580k24g4v	7	11	thermodynamic	thermodynamic	ADJ
nc580k24g4v	7	12	data	datum	NOUN
nc580k24g4v	7	13	,	,	PUNCT
nc580k24g4v	7	14	yet	yet	CCONJ
nc580k24g4v	7	15	the	the	DET
nc580k24g4v	7	16	pre	pre	ADJ
nc580k24g4v	7	17	-	-	ADJ
nc580k24g4v	7	18	existing	exist	VERB
nc580k24g4v	7	19	flexibility	flexibility	NOUN
nc580k24g4v	7	20	of	of	ADP
nc580k24g4v	7	21	the	the	DET
nc580k24g4v	7	22	receptor	receptor	NOUN
nc580k24g4v	7	23	at	at	ADP
nc580k24g4v	7	24	its	its	PRON
nc580k24g4v	7	25	binding	bind	VERB
nc580k24g4v	7	26	surface	surface	NOUN
nc580k24g4v	7	27	has	have	AUX
nc580k24g4v	7	28	gone	go	VERB
nc580k24g4v	7	29	relatively	relatively	ADV
nc580k24g4v	7	30	unidentified	unidentified	ADJ
nc580k24g4v	7	31	.	.	PUNCT
nc580k24g4v	8	1	here	here	ADV
nc580k24g4v	8	2	we	we	PRON
nc580k24g4v	8	3	address	address	VERB
nc580k24g4v	8	4	the	the	DET
nc580k24g4v	8	5	fundamental	fundamental	ADJ
nc580k24g4v	8	6	dynamics	dynamic	NOUN
nc580k24g4v	8	7	of	of	ADP
nc580k24g4v	8	8	the	the	DET
nc580k24g4v	8	9	a6	a6	PROPN
nc580k24g4v	8	10	tcr	tcr	PROPN
nc580k24g4v	8	11	protein	protein	NOUN
nc580k24g4v	8	12	,	,	PUNCT
nc580k24g4v	8	13	and	and	CCONJ
nc580k24g4v	8	14	consider	consider	VERB
nc580k24g4v	8	15	the	the	DET
nc580k24g4v	8	16	potential	potential	ADJ
nc580k24g4v	8	17	effects	effect	NOUN
nc580k24g4v	8	18	its	its	PRON
nc580k24g4v	8	19	conformational	conformational	ADJ
nc580k24g4v	8	20	variability	variability	NOUN
nc580k24g4v	8	21	may	may	AUX
nc580k24g4v	8	22	impose	impose	VERB
nc580k24g4v	8	23	on	on	ADP
nc580k24g4v	8	24	its	its	PRON
nc580k24g4v	8	25	recognition	recognition	NOUN
nc580k24g4v	8	26	strategy	strategy	NOUN
nc580k24g4v	8	27	.	.	PUNCT
nc580k24g4v	9	1	by	by	ADP
nc580k24g4v	9	2	the	the	DET
nc580k24g4v	9	3	means	mean	NOUN
nc580k24g4v	9	4	of	of	ADP
nc580k24g4v	9	5	time	time	NOUN
nc580k24g4v	9	6	-	-	PUNCT
nc580k24g4v	9	7	resolved	resolve	VERB
nc580k24g4v	9	8	fluorescence	fluorescence	ADJ
nc580k24g4v	9	9	anisotropy	anisotropy	NOUN
nc580k24g4v	9	10	and	and	CCONJ
nc580k24g4v	9	11	molecular	molecular	ADJ
nc580k24g4v	9	12	dynamics	dynamic	NOUN
nc580k24g4v	9	13	simulations	simulation	NOUN
nc580k24g4v	9	14	,	,	PUNCT
nc580k24g4v	9	15	distinct	distinct	ADJ
nc580k24g4v	9	16	and	and	CCONJ
nc580k24g4v	9	17	measureable	measureable	ADJ
nc580k24g4v	9	18	flexibilities	flexibility	NOUN
nc580k24g4v	9	19	of	of	ADP
nc580k24g4v	9	20	the	the	DET
nc580k24g4v	9	21	antigen	antigen	NOUN
nc580k24g4v	9	22	-	-	PUNCT
nc580k24g4v	9	23	binding	bind	VERB
nc580k24g4v	9	24	loops	loop	NOUN
nc580k24g4v	9	25	of	of	ADP
nc580k24g4v	9	26	a6	a6	PROPN
nc580k24g4v	9	27	have	have	AUX
nc580k24g4v	9	28	been	be	AUX
nc580k24g4v	9	29	determined	determine	VERB
nc580k24g4v	9	30	.	.	PUNCT
nc580k24g4v	10	1	towards	towards	ADP
nc580k24g4v	10	2	the	the	DET
nc580k24g4v	10	3	ultimate	ultimate	ADJ
nc580k24g4v	10	4	goal	goal	NOUN
nc580k24g4v	10	5	of	of	ADP
nc580k24g4v	10	6	elucidating	elucidate	VERB
nc580k24g4v	10	7	the	the	DET
nc580k24g4v	10	8	receptor	receptor	NOUN
nc580k24g4v	10	9	's	's	PART
nc580k24g4v	10	10	recognition	recognition	NOUN
nc580k24g4v	10	11	mechanism	mechanism	NOUN
nc580k24g4v	10	12	,	,	PUNCT
nc580k24g4v	10	13	a	a	DET
nc580k24g4v	10	14	comprehensive	comprehensive	ADJ
nc580k24g4v	10	15	analysis	analysis	NOUN
nc580k24g4v	10	16	of	of	ADP
nc580k24g4v	10	17	the	the	DET
nc580k24g4v	10	18	data	datum	NOUN
nc580k24g4v	10	19	from	from	ADP
nc580k24g4v	10	20	both	both	CCONJ
nc580k24g4v	10	21	structural	structural	ADJ
nc580k24g4v	10	22	and	and	CCONJ
nc580k24g4v	10	23	energetic	energetic	ADJ
nc580k24g4v	10	24	perspectives	perspective	NOUN
nc580k24g4v	10	25	have	have	AUX
nc580k24g4v	10	26	been	be	AUX
nc580k24g4v	10	27	critically	critically	ADV
nc580k24g4v	10	28	performed	perform	VERB
nc580k24g4v	10	29	.	.	PUNCT