id sid tid token lemma pos mw22v408s7s 1 1 ibd ibd VERB mw22v408s7s 1 2 is be AUX mw22v408s7s 1 3 comprised comprise VERB mw22v408s7s 1 4 of of ADP mw22v408s7s 1 5 ulcerative ulcerative ADJ mw22v408s7s 1 6 colitis colitis NOUN mw22v408s7s 1 7 ( ( PUNCT mw22v408s7s 1 8 uc uc PROPN mw22v408s7s 1 9 ) ) PUNCT mw22v408s7s 1 10 and and CCONJ mw22v408s7s 1 11 crohn crohn PROPN mw22v408s7s 1 12 's 's PART mw22v408s7s 1 13 disease disease NOUN mw22v408s7s 1 14 ( ( PUNCT mw22v408s7s 1 15 cd cd PROPN mw22v408s7s 1 16 ) ) PUNCT mw22v408s7s 1 17 and and CCONJ mw22v408s7s 1 18 is be AUX mw22v408s7s 1 19 characterized characterize VERB mw22v408s7s 1 20 by by ADP mw22v408s7s 1 21 excessive excessive ADJ mw22v408s7s 1 22 chronic chronic ADJ mw22v408s7s 1 23 inflammation inflammation NOUN mw22v408s7s 1 24 in in ADP mw22v408s7s 1 25 the the DET mw22v408s7s 1 26 intestinal intestinal ADJ mw22v408s7s 1 27 lining lining NOUN mw22v408s7s 1 28 . . PUNCT mw22v408s7s 2 1 although although SCONJ mw22v408s7s 2 2 the the DET mw22v408s7s 2 3 exact exact ADJ mw22v408s7s 2 4 mechanisms mechanism NOUN mw22v408s7s 2 5 underlying underlie VERB mw22v408s7s 2 6 ibd ibd NOUN mw22v408s7s 2 7 are be AUX mw22v408s7s 2 8 not not PART mw22v408s7s 2 9 fully fully ADV mw22v408s7s 2 10 known know VERB mw22v408s7s 2 11 , , PUNCT mw22v408s7s 2 12 the the DET mw22v408s7s 2 13 consensus consensus NOUN mw22v408s7s 2 14 stipulates stipulate VERB mw22v408s7s 2 15 it it PRON mw22v408s7s 2 16 is be AUX mw22v408s7s 2 17 driven drive VERB mw22v408s7s 2 18 by by ADP mw22v408s7s 2 19 the the DET mw22v408s7s 2 20 interplay interplay NOUN mw22v408s7s 2 21 of of ADP mw22v408s7s 2 22 genetic genetic ADJ mw22v408s7s 2 23 mutations mutation NOUN mw22v408s7s 2 24 , , PUNCT mw22v408s7s 2 25 the the DET mw22v408s7s 2 26 immune immune ADJ mw22v408s7s 2 27 system system NOUN mw22v408s7s 2 28 , , PUNCT mw22v408s7s 2 29 and and CCONJ mw22v408s7s 2 30 the the DET mw22v408s7s 2 31 microbial microbial ADJ mw22v408s7s 2 32 community community NOUN mw22v408s7s 2 33 within within ADP mw22v408s7s 2 34 an an DET mw22v408s7s 2 35 organism organism NOUN mw22v408s7s 2 36 . . PUNCT mw22v408s7s 3 1 tnfaip3 tnfaip3 NOUN mw22v408s7s 3 2 is be AUX mw22v408s7s 3 3 an an DET mw22v408s7s 3 4 essential essential ADJ mw22v408s7s 3 5 modulator modulator NOUN mw22v408s7s 3 6 of of ADP mw22v408s7s 3 7 pro pro ADJ mw22v408s7s 3 8 - - ADJ mw22v408s7s 3 9 inflammatory inflammatory ADJ mw22v408s7s 3 10 signaling signaling NOUN mw22v408s7s 3 11 and and CCONJ mw22v408s7s 3 12 is be AUX mw22v408s7s 3 13 implicated implicate VERB mw22v408s7s 3 14 in in ADP mw22v408s7s 3 15 many many ADJ mw22v408s7s 3 16 autoimmune autoimmune ADJ mw22v408s7s 3 17 diseases disease NOUN mw22v408s7s 3 18 ( ( PUNCT mw22v408s7s 3 19 ad ad NOUN mw22v408s7s 3 20 ) ) PUNCT mw22v408s7s 3 21 , , PUNCT mw22v408s7s 3 22 including include VERB mw22v408s7s 3 23 inflammatory inflammatory ADJ mw22v408s7s 3 24 bowel bowel NOUN mw22v408s7s 3 25 disease disease NOUN mw22v408s7s 3 26 ( ( PUNCT mw22v408s7s 3 27 ibd ibd NOUN mw22v408s7s 3 28 ) ) PUNCT mw22v408s7s 3 29 . . PUNCT mw22v408s7s 4 1 the the DET mw22v408s7s 4 2 overall overall ADJ mw22v408s7s 4 3 objective objective NOUN mw22v408s7s 4 4 of of ADP mw22v408s7s 4 5 this this DET mw22v408s7s 4 6 research research NOUN mw22v408s7s 4 7 proposal proposal NOUN mw22v408s7s 4 8 is be AUX mw22v408s7s 4 9 to to PART mw22v408s7s 4 10 define define VERB mw22v408s7s 4 11 the the DET mw22v408s7s 4 12 role role NOUN mw22v408s7s 4 13 of of ADP mw22v408s7s 4 14 tnfaip3 tnfaip3 ADJ mw22v408s7s 4 15 expression expression NOUN mw22v408s7s 4 16 in in ADP mw22v408s7s 4 17 iec iec ADJ mw22v408s7s 4 18 and and CCONJ mw22v408s7s 4 19 innate innate VERB mw22v408s7s 4 20 immunity immunity NOUN mw22v408s7s 4 21 in in ADP mw22v408s7s 4 22 ibd.tnfaip3 ibd.tnfaip3 PROPN mw22v408s7s 4 23 is be AUX mw22v408s7s 4 24 an an DET mw22v408s7s 4 25 anti anti ADJ mw22v408s7s 4 26 - - ADJ mw22v408s7s 4 27 inflammatory inflammatory ADJ mw22v408s7s 4 28 enzyme enzyme NOUN mw22v408s7s 4 29 inhibiting inhibit VERB mw22v408s7s 4 30 nf nf NOUN mw22v408s7s 4 31 - - PUNCT mw22v408s7s 4 32 κb κb NOUN mw22v408s7s 4 33 through through ADP mw22v408s7s 4 34 a a DET mw22v408s7s 4 35 negative negative ADJ mw22v408s7s 4 36 feedback feedback NOUN mw22v408s7s 4 37 loop loop NOUN mw22v408s7s 4 38 . . PUNCT mw22v408s7s 5 1 in in ADP mw22v408s7s 5 2 intestinal intestinal ADJ mw22v408s7s 5 3 epithelium epithelium NOUN mw22v408s7s 5 4 cells cell NOUN mw22v408s7s 5 5 ( ( PUNCT mw22v408s7s 5 6 iec iec ADV mw22v408s7s 5 7 ) ) PUNCT mw22v408s7s 5 8 it it PRON mw22v408s7s 5 9 prevents prevent VERB mw22v408s7s 5 10 iec iec ADJ mw22v408s7s 5 11 apoptosis apoptosis NOUN mw22v408s7s 5 12 and and CCONJ mw22v408s7s 5 13 increases increase VERB mw22v408s7s 5 14 barrier barrier NOUN mw22v408s7s 5 15 function function NOUN mw22v408s7s 5 16 , , PUNCT mw22v408s7s 5 17 thus thus ADV mw22v408s7s 5 18 tnfaip3 tnfaip3 NOUN mw22v408s7s 5 19 in in ADP mw22v408s7s 5 20 iec iec NOUN mw22v408s7s 5 21 is be AUX mw22v408s7s 5 22 implicated implicate VERB mw22v408s7s 5 23 as as ADP mw22v408s7s 5 24 a a DET mw22v408s7s 5 25 key key ADJ mw22v408s7s 5 26 player player NOUN mw22v408s7s 5 27 in in ADP mw22v408s7s 5 28 colitis colitis PROPN mw22v408s7s 5 29 . . PUNCT mw22v408s7s 6 1 to to PART mw22v408s7s 6 2 assess assess VERB mw22v408s7s 6 3 the the DET mw22v408s7s 6 4 role role NOUN mw22v408s7s 6 5 of of ADP mw22v408s7s 6 6 tnfaip3 tnfaip3 NOUN mw22v408s7s 6 7 on on ADP mw22v408s7s 6 8 innate innate ADJ mw22v408s7s 6 9 immune immune ADJ mw22v408s7s 6 10 system system NOUN mw22v408s7s 6 11 driven drive VERB mw22v408s7s 6 12 colitis colitis NOUN mw22v408s7s 6 13 , , PUNCT mw22v408s7s 6 14 we we PRON mw22v408s7s 6 15 crossed cross VERB mw22v408s7s 6 16 rag-1-/mice rag-1-/mice NOUN mw22v408s7s 6 17 , , PUNCT mw22v408s7s 6 18 immunocompromised immunocompromise VERB mw22v408s7s 6 19 mice mouse NOUN mw22v408s7s 6 20 lacking lack VERB mw22v408s7s 6 21 t t NOUN mw22v408s7s 6 22 and and CCONJ mw22v408s7s 6 23 b b NOUN mw22v408s7s 6 24 cells cell NOUN mw22v408s7s 6 25 , , PUNCT mw22v408s7s 6 26 and and CCONJ mw22v408s7s 6 27 villin villin NOUN mw22v408s7s 6 28 - - PUNCT mw22v408s7s 6 29 tnfaip3 tnfaip3 NOUN mw22v408s7s 6 30 transgenic transgenic NOUN mw22v408s7s 6 31 mice mouse NOUN mw22v408s7s 6 32 , , PUNCT mw22v408s7s 6 33 which which PRON mw22v408s7s 6 34 overexpress overexpress VERB mw22v408s7s 6 35 tnfaip3 tnfaip3 NOUN mw22v408s7s 6 36 in in ADP mw22v408s7s 6 37 iec iec ADV mw22v408s7s 6 38 , , PUNCT mw22v408s7s 6 39 these these DET mw22v408s7s 6 40 mice mouse NOUN mw22v408s7s 6 41 hereafter hereafter ADV mw22v408s7s 6 42 are be AUX mw22v408s7s 6 43 referred refer VERB mw22v408s7s 6 44 to to ADP mw22v408s7s 6 45 as as ADP mw22v408s7s 6 46 trag trag ADJ mw22v408s7s 6 47 mice mouse NOUN mw22v408s7s 6 48 . . PUNCT mw22v408s7s 7 1 neither neither CCONJ mw22v408s7s 7 2 rag-1-/nor rag-1-/nor VERB mw22v408s7s 7 3 v v ADJ mw22v408s7s 7 4 - - PUNCT mw22v408s7s 7 5 tnfaip3 tnfaip3 NOUN mw22v408s7s 7 6 mice mouse NOUN mw22v408s7s 7 7 spontaneously spontaneously ADV mw22v408s7s 7 8 develop develop VERB mw22v408s7s 7 9 colitis colitis NOUN mw22v408s7s 7 10 , , PUNCT mw22v408s7s 7 11 but but CCONJ mw22v408s7s 7 12 all all DET mw22v408s7s 7 13 v v NOUN mw22v408s7s 7 14 - - PUNCT mw22v408s7s 7 15 tnfaip3 tnfaip3 NOUN mw22v408s7s 7 16 x x PUNCT mw22v408s7s 7 17 rag-1-/mice rag-1-/mice NOUN mw22v408s7s 7 18 exhibited exhibit VERB mw22v408s7s 7 19 early early ADJ mw22v408s7s 7 20 onset onset NOUN mw22v408s7s 7 21 spontaneous spontaneous ADJ mw22v408s7s 7 22 colitis colitis NOUN mw22v408s7s 7 23 around around ADP mw22v408s7s 7 24 6 6 NUM mw22v408s7s 7 25 - - SYM mw22v408s7s 7 26 8 8 NUM mw22v408s7s 7 27 weeks week NOUN mw22v408s7s 7 28 of of ADP mw22v408s7s 7 29 age age NOUN mw22v408s7s 7 30 . . PUNCT mw22v408s7s 8 1 trag trag ADJ mw22v408s7s 8 2 mice mouse NOUN mw22v408s7s 8 3 display display NOUN mw22v408s7s 8 4 upregulation upregulation NOUN mw22v408s7s 8 5 of of ADP mw22v408s7s 8 6 proinflammatory proinflammatory ADJ mw22v408s7s 8 7 cytokines cytokine NOUN mw22v408s7s 8 8 , , PUNCT mw22v408s7s 8 9 inflammatory inflammatory ADJ mw22v408s7s 8 10 monocytes monocyte NOUN mw22v408s7s 8 11 , , PUNCT mw22v408s7s 8 12 neutrophils neutrophil NOUN mw22v408s7s 8 13 , , PUNCT mw22v408s7s 8 14 and and CCONJ mw22v408s7s 8 15 innate innate VERB mw22v408s7s 8 16 lymphoid lymphoid NOUN mw22v408s7s 8 17 cells cell NOUN mw22v408s7s 8 18 ( ( PUNCT mw22v408s7s 8 19 ilcs ilcs NOUN mw22v408s7s 8 20 ) ) PUNCT mw22v408s7s 8 21 . . PUNCT mw22v408s7s 9 1 we we PRON mw22v408s7s 9 2 found find VERB mw22v408s7s 9 3 the the DET mw22v408s7s 9 4 inhibition inhibition NOUN mw22v408s7s 9 5 of of ADP mw22v408s7s 9 6 ilcs ilcs NOUN mw22v408s7s 9 7 ameliorated ameliorate VERB mw22v408s7s 9 8 colitis colitis NOUN mw22v408s7s 9 9 , , PUNCT mw22v408s7s 9 10 both both PRON mw22v408s7s 9 11 prophylactically prophylactically ADV mw22v408s7s 9 12 and and CCONJ mw22v408s7s 9 13 therapeutically therapeutically ADV mw22v408s7s 9 14 . . PUNCT mw22v408s7s 10 1 furthermore furthermore ADV mw22v408s7s 10 2 , , PUNCT mw22v408s7s 10 3 targeting target VERB mw22v408s7s 10 4 jak jak PROPN mw22v408s7s 10 5 pathways pathway NOUN mw22v408s7s 10 6 essential essential ADJ mw22v408s7s 10 7 for for ADP mw22v408s7s 10 8 inducing induce VERB mw22v408s7s 10 9 and and CCONJ mw22v408s7s 10 10 secreting secrete VERB mw22v408s7s 10 11 ilcs ilcs NOUN mw22v408s7s 10 12 cytokines cytokine NOUN mw22v408s7s 10 13 also also ADV mw22v408s7s 10 14 showed show VERB mw22v408s7s 10 15 ameliorating ameliorate VERB mw22v408s7s 10 16 effects effect NOUN mw22v408s7s 10 17 on on ADP mw22v408s7s 10 18 colitis colitis NOUN mw22v408s7s 10 19 , , PUNCT mw22v408s7s 10 20 however however ADV mw22v408s7s 10 21 , , PUNCT mw22v408s7s 10 22 targeting target VERB mw22v408s7s 10 23 inflammatory inflammatory ADJ mw22v408s7s 10 24 cytokines cytokine NOUN mw22v408s7s 10 25 has have VERB mw22v408s7s 10 26 no no DET mw22v408s7s 10 27 effect effect NOUN mw22v408s7s 10 28 . . PUNCT mw22v408s7s 11 1 thus thus ADV mw22v408s7s 11 2 , , PUNCT mw22v408s7s 11 3 ilcs ilcs NOUN mw22v408s7s 11 4 are be AUX mw22v408s7s 11 5 the the DET mw22v408s7s 11 6 main main ADJ mw22v408s7s 11 7 drivers driver NOUN mw22v408s7s 11 8 of of ADP mw22v408s7s 11 9 inflammation inflammation NOUN mw22v408s7s 11 10 in in ADP mw22v408s7s 11 11 our our PRON mw22v408s7s 11 12 model model NOUN mw22v408s7s 11 13 . . PUNCT mw22v408s7s 12 1 these these DET mw22v408s7s 12 2 mice mouse NOUN mw22v408s7s 12 3 also also ADV mw22v408s7s 12 4 presented present VERB mw22v408s7s 12 5 altered alter VERB mw22v408s7s 12 6 anti anti ADJ mw22v408s7s 12 7 - - ADJ mw22v408s7s 12 8 microbial microbial ADJ mw22v408s7s 12 9 factor factor NOUN mw22v408s7s 12 10 expression expression NOUN mw22v408s7s 12 11 and and CCONJ mw22v408s7s 12 12 displayed display VERB mw22v408s7s 12 13 an an DET mw22v408s7s 12 14 inner inner ADJ mw22v408s7s 12 15 mucus mucus NOUN mw22v408s7s 12 16 ( ( PUNCT mw22v408s7s 12 17 i i PRON mw22v408s7s 12 18 m m VERB mw22v408s7s 12 19 ) ) PUNCT mw22v408s7s 12 20 layer layer NOUN mw22v408s7s 12 21 infiltrated infiltrate VERB mw22v408s7s 12 22 with with ADP mw22v408s7s 12 23 microbes microbe NOUN mw22v408s7s 12 24 . . PUNCT mw22v408s7s 13 1 16s 16 NOUN mw22v408s7s 13 2 sequencing sequence VERB mw22v408s7s 13 3 analysis analysis NOUN mw22v408s7s 13 4 reveled revel VERB mw22v408s7s 13 5 the the DET mw22v408s7s 13 6 trag trag ADJ mw22v408s7s 13 7 mice mouse NOUN mw22v408s7s 13 8 have have VERB mw22v408s7s 13 9 an an DET mw22v408s7s 13 10 upregulation upregulation NOUN mw22v408s7s 13 11 of of ADP mw22v408s7s 13 12 pathogenic pathogenic ADJ mw22v408s7s 13 13 bacteria bacteria NOUN mw22v408s7s 13 14 and and CCONJ mw22v408s7s 13 15 a a DET mw22v408s7s 13 16 downregulation downregulation NOUN mw22v408s7s 13 17 of of ADP mw22v408s7s 13 18 commensal commensal ADJ mw22v408s7s 13 19 bacteria bacteria NOUN mw22v408s7s 13 20 in in ADP mw22v408s7s 13 21 the the DET mw22v408s7s 13 22 inner inner ADJ mw22v408s7s 13 23 mucus mucus NOUN mw22v408s7s 13 24 layer layer NOUN mw22v408s7s 13 25 compared compare VERB mw22v408s7s 13 26 to to ADP mw22v408s7s 13 27 the the DET mw22v408s7s 13 28 rag rag NOUN mw22v408s7s 13 29 mice mouse NOUN mw22v408s7s 13 30 . . PUNCT mw22v408s7s 14 1 thus thus ADV mw22v408s7s 14 2 , , PUNCT mw22v408s7s 14 3 we we PRON mw22v408s7s 14 4 believe believe VERB mw22v408s7s 14 5 that that SCONJ mw22v408s7s 14 6 early early ADJ mw22v408s7s 14 7 onset onset NOUN mw22v408s7s 14 8 spontaneous spontaneous ADJ mw22v408s7s 14 9 colitis colitis NOUN mw22v408s7s 14 10 in in ADP mw22v408s7s 14 11 this this DET mw22v408s7s 14 12 model model NOUN mw22v408s7s 14 13 is be AUX mw22v408s7s 14 14 attributed attribute VERB mw22v408s7s 14 15 to to ADP mw22v408s7s 14 16 both both CCONJ mw22v408s7s 14 17 the the DET mw22v408s7s 14 18 immunocompromised immunocompromise VERB mw22v408s7s 14 19 state state NOUN mw22v408s7s 14 20 and and CCONJ mw22v408s7s 14 21 microbes microbe NOUN mw22v408s7s 14 22 invading invade VERB mw22v408s7s 14 23 the the DET mw22v408s7s 14 24 i i NOUN mw22v408s7s 14 25 m. m. VERB mw22v408s7s 14 26 the the DET mw22v408s7s 14 27 microbial microbial ADJ mw22v408s7s 14 28 invasion invasion NOUN mw22v408s7s 14 29 caused cause VERB mw22v408s7s 14 30 the the DET mw22v408s7s 14 31 alteration alteration NOUN mw22v408s7s 14 32 of of ADP mw22v408s7s 14 33 antimicrobial antimicrobial ADJ mw22v408s7s 14 34 factors factor NOUN mw22v408s7s 14 35 by by ADP mw22v408s7s 14 36 the the DET mw22v408s7s 14 37 over over ADJ mw22v408s7s 14 38 expression expression NOUN mw22v408s7s 14 39 of of ADP mw22v408s7s 14 40 tnfaip3 tnfaip3 NOUN mw22v408s7s 14 41 allows allow VERB mw22v408s7s 14 42 opportunistic opportunistic ADJ mw22v408s7s 14 43 bacteria bacteria NOUN mw22v408s7s 14 44 to to PART mw22v408s7s 14 45 infiltrate infiltrate VERB mw22v408s7s 14 46 the the DET mw22v408s7s 14 47 i i NOUN mw22v408s7s 14 48 m m VERB mw22v408s7s 14 49 layer layer NOUN mw22v408s7s 14 50 and and CCONJ mw22v408s7s 14 51 come come VERB mw22v408s7s 14 52 into into ADP mw22v408s7s 14 53 contact contact NOUN mw22v408s7s 14 54 with with ADP mw22v408s7s 14 55 the the DET mw22v408s7s 14 56 intestinal intestinal ADJ mw22v408s7s 14 57 epithelium epithelium NOUN mw22v408s7s 14 58 . . PUNCT mw22v408s7s 15 1 this this PRON mw22v408s7s 15 2 triggers trigger VERB mw22v408s7s 15 3 inflammatory inflammatory ADJ mw22v408s7s 15 4 cytokine cytokine NOUN mw22v408s7s 15 5 production production NOUN mw22v408s7s 15 6 by by ADP mw22v408s7s 15 7 antigen antigen NOUN mw22v408s7s 15 8 presenting present VERB mw22v408s7s 15 9 cells cell NOUN mw22v408s7s 15 10 , , PUNCT mw22v408s7s 15 11 and and CCONJ mw22v408s7s 15 12 the the DET mw22v408s7s 15 13 upregulation upregulation NOUN mw22v408s7s 15 14 of of ADP mw22v408s7s 15 15 ilcs ilcs NOUN mw22v408s7s 15 16 . . PUNCT mw22v408s7s 16 1 the the DET mw22v408s7s 16 2 ilcs ilcs NOUN mw22v408s7s 16 3 further far ADV mw22v408s7s 16 4 propagate propagate VERB mw22v408s7s 16 5 the the DET mw22v408s7s 16 6 inflammation inflammation NOUN mw22v408s7s 16 7 with with ADP mw22v408s7s 16 8 secreting secrete VERB mw22v408s7s 16 9 on on ADP mw22v408s7s 16 10 inflammatory inflammatory ADJ mw22v408s7s 16 11 cytokines cytokine NOUN mw22v408s7s 16 12 and and CCONJ mw22v408s7s 16 13 increasing increase VERB mw22v408s7s 16 14 inflammatory inflammatory ADJ mw22v408s7s 16 15 cells cell NOUN mw22v408s7s 16 16 , , PUNCT mw22v408s7s 16 17 thus thus ADV mw22v408s7s 16 18 , , PUNCT mw22v408s7s 16 19 leading lead VERB mw22v408s7s 16 20 to to ADP mw22v408s7s 16 21 the the DET mw22v408s7s 16 22 spontaneous spontaneous ADJ mw22v408s7s 16 23 chronic chronic ADJ mw22v408s7s 16 24 inflammation inflammation NOUN mw22v408s7s 16 25 displayed display VERB mw22v408s7s 16 26 by by ADP mw22v408s7s 16 27 our our PRON mw22v408s7s 16 28 model model NOUN mw22v408s7s 16 29 . . PUNCT