id	sid	tid	token	lemma	pos
mp48sb41k33	1	1	mass	mass	PROPN
mp48sb41k33	1	2	drug	drug	PROPN
mp48sb41k33	1	3	administration	administration	NOUN
mp48sb41k33	1	4	,	,	PUNCT
mp48sb41k33	1	5	a	a	DET
mp48sb41k33	1	6	key	key	ADJ
mp48sb41k33	1	7	malaria	malaria	NOUN
mp48sb41k33	1	8	control	control	NOUN
mp48sb41k33	1	9	strategy	strategy	NOUN
mp48sb41k33	1	10	,	,	PUNCT
mp48sb41k33	1	11	has	have	AUX
mp48sb41k33	1	12	been	be	AUX
mp48sb41k33	1	13	thwarted	thwart	VERB
mp48sb41k33	1	14	by	by	ADP
mp48sb41k33	1	15	the	the	DET
mp48sb41k33	1	16	development	development	NOUN
mp48sb41k33	1	17	of	of	ADP
mp48sb41k33	1	18	drug	drug	NOUN
mp48sb41k33	1	19	resistance	resistance	NOUN
mp48sb41k33	1	20	to	to	ADP
mp48sb41k33	1	21	nearly	nearly	ADV
mp48sb41k33	1	22	all	all	DET
mp48sb41k33	1	23	classes	class	NOUN
mp48sb41k33	1	24	of	of	ADP
mp48sb41k33	1	25	antimalarials	antimalarial	NOUN
mp48sb41k33	1	26	in	in	ADP
mp48sb41k33	1	27	use	use	NOUN
mp48sb41k33	1	28	.	.	PUNCT
mp48sb41k33	2	1	antifolate	antifolate	ADJ
mp48sb41k33	2	2	drugs	drug	NOUN
mp48sb41k33	2	3	are	be	AUX
mp48sb41k33	2	4	antimalarial	antimalarial	ADJ
mp48sb41k33	2	5	compounds	compound	NOUN
mp48sb41k33	2	6	that	that	PRON
mp48sb41k33	2	7	target	target	VERB
mp48sb41k33	2	8	and	and	CCONJ
mp48sb41k33	2	9	inhibit	inhibit	VERB
mp48sb41k33	2	10	the	the	DET
mp48sb41k33	2	11	folate	folate	NOUN
mp48sb41k33	2	12	pathway	pathway	NOUN
mp48sb41k33	2	13	necessary	necessary	ADJ
mp48sb41k33	2	14	for	for	ADP
mp48sb41k33	2	15	pyrimidine	pyrimidine	NOUN
mp48sb41k33	2	16	synthesis	synthesis	NOUN
mp48sb41k33	2	17	in	in	ADP
mp48sb41k33	2	18	the	the	DET
mp48sb41k33	2	19	blood	blood	NOUN
mp48sb41k33	2	20	stage	stage	NOUN
mp48sb41k33	2	21	parasite	parasite	NOUN
mp48sb41k33	2	22	.	.	PUNCT
mp48sb41k33	3	1	discovering	discover	VERB
mp48sb41k33	3	2	and	and	CCONJ
mp48sb41k33	3	3	understanding	understand	VERB
mp48sb41k33	3	4	the	the	DET
mp48sb41k33	3	5	evolution	evolution	NOUN
mp48sb41k33	3	6	of	of	ADP
mp48sb41k33	3	7	resistance	resistance	NOUN
mp48sb41k33	3	8	is	be	AUX
mp48sb41k33	3	9	essential	essential	ADJ
mp48sb41k33	3	10	to	to	ADP
mp48sb41k33	3	11	developing	develop	VERB
mp48sb41k33	3	12	novel	novel	ADJ
mp48sb41k33	3	13	treatment	treatment	NOUN
mp48sb41k33	3	14	regimes	regime	NOUN
mp48sb41k33	3	15	and	and	CCONJ
mp48sb41k33	3	16	avoiding	avoid	VERB
mp48sb41k33	3	17	future	future	ADJ
mp48sb41k33	3	18	treatment	treatment	NOUN
mp48sb41k33	3	19	failure	failure	NOUN
mp48sb41k33	3	20	.	.	PUNCT
mp48sb41k33	4	1	previous	previous	ADJ
mp48sb41k33	4	2	studies	study	NOUN
mp48sb41k33	4	3	of	of	ADP
mp48sb41k33	4	4	p.	p.	PROPN
mp48sb41k33	4	5	falciparum	falciparum	PROPN
mp48sb41k33	4	6	malaria	malaria	NOUN
mp48sb41k33	4	7	parasites	parasite	NOUN
mp48sb41k33	4	8	derived	derive	VERB
mp48sb41k33	4	9	from	from	ADP
mp48sb41k33	4	10	the	the	DET
mp48sb41k33	4	11	field	field	NOUN
mp48sb41k33	4	12	isolates	isolate	NOUN
mp48sb41k33	4	13	suggest	suggest	VERB
mp48sb41k33	4	14	an	an	DET
mp48sb41k33	4	15	association	association	NOUN
mp48sb41k33	4	16	between	between	ADP
mp48sb41k33	4	17	gch1	gch1	PROPN
mp48sb41k33	4	18	copy	copy	NOUN
mp48sb41k33	4	19	number	number	NOUN
mp48sb41k33	4	20	variations	variation	NOUN
mp48sb41k33	4	21	(	(	PUNCT
mp48sb41k33	4	22	cnvs	cnvs	PROPN
mp48sb41k33	4	23	)	)	PUNCT
mp48sb41k33	4	24	and	and	CCONJ
mp48sb41k33	4	25	resistance	resistance	NOUN
mp48sb41k33	4	26	to	to	ADP
mp48sb41k33	4	27	the	the	DET
mp48sb41k33	4	28	antimalarial	antimalarial	ADJ
mp48sb41k33	4	29	drug	drug	NOUN
mp48sb41k33	4	30	pyrimethamine	pyrimethamine	NOUN
mp48sb41k33	4	31	(	(	PUNCT
mp48sb41k33	4	32	pyr	pyr	NOUN
mp48sb41k33	4	33	)	)	PUNCT
mp48sb41k33	4	34	.	.	PUNCT
mp48sb41k33	5	1	however	however	ADV
mp48sb41k33	5	2	,	,	PUNCT
mp48sb41k33	5	3	the	the	DET
mp48sb41k33	5	4	actual	actual	ADJ
mp48sb41k33	5	5	functional	functional	ADJ
mp48sb41k33	5	6	role	role	NOUN
mp48sb41k33	5	7	of	of	ADP
mp48sb41k33	5	8	this	this	DET
mp48sb41k33	5	9	cnv	cnv	NOUN
mp48sb41k33	5	10	on	on	ADP
mp48sb41k33	5	11	drug	drug	NOUN
mp48sb41k33	5	12	sensitivity	sensitivity	NOUN
mp48sb41k33	5	13	and	and	CCONJ
mp48sb41k33	5	14	parasite	parasite	NOUN
mp48sb41k33	5	15	fitness	fitness	NOUN
mp48sb41k33	5	16	has	have	AUX
mp48sb41k33	5	17	not	not	PART
mp48sb41k33	5	18	been	be	AUX
mp48sb41k33	5	19	determined	determine	VERB
mp48sb41k33	5	20	.	.	PUNCT
mp48sb41k33	6	1	using	use	VERB
mp48sb41k33	6	2	the	the	DET
mp48sb41k33	6	3	parents	parent	NOUN
mp48sb41k33	6	4	and	and	CCONJ
mp48sb41k33	6	5	progeny	progeny	NOUN
mp48sb41k33	6	6	of	of	ADP
mp48sb41k33	6	7	the	the	DET
mp48sb41k33	6	8	genetic	genetic	PROPN
mp48sb41k33	6	9	cross	cross	PROPN
mp48sb41k33	6	10	between	between	ADP
mp48sb41k33	6	11	clonal	clonal	ADJ
mp48sb41k33	6	12	parent	parent	NOUN
mp48sb41k33	6	13	lines	line	NOUN
mp48sb41k33	6	14	,	,	PUNCT
mp48sb41k33	6	15	hb3	hb3	NOUN
mp48sb41k33	6	16	and	and	CCONJ
mp48sb41k33	6	17	dd2	dd2	PROPN
mp48sb41k33	6	18	,	,	PUNCT
mp48sb41k33	6	19	we	we	PRON
mp48sb41k33	6	20	identified	identify	VERB
mp48sb41k33	6	21	a	a	DET
mp48sb41k33	6	22	positive	positive	ADJ
mp48sb41k33	6	23	correlation	correlation	NOUN
mp48sb41k33	6	24	between	between	ADP
mp48sb41k33	6	25	gch1	gch1	PROPN
mp48sb41k33	6	26	copy	copy	NOUN
mp48sb41k33	6	27	number	number	NOUN
mp48sb41k33	6	28	(	(	PUNCT
mp48sb41k33	6	29	cn	cn	PROPN
mp48sb41k33	6	30	)	)	PUNCT
mp48sb41k33	6	31	and	and	CCONJ
mp48sb41k33	6	32	pyr	pyr	NOUN
mp48sb41k33	6	33	ic50	ic50	PROPN
mp48sb41k33	6	34	values	value	NOUN
mp48sb41k33	6	35	and	and	CCONJ
mp48sb41k33	6	36	confirmed	confirm	VERB
mp48sb41k33	6	37	the	the	DET
mp48sb41k33	6	38	phenotypic	phenotypic	ADJ
mp48sb41k33	6	39	effect	effect	NOUN
mp48sb41k33	6	40	of	of	ADP
mp48sb41k33	6	41	the	the	DET
mp48sb41k33	6	42	gch1	gch1	PROPN
mp48sb41k33	6	43	cnv	cnv	PROPN
mp48sb41k33	6	44	by	by	ADP
mp48sb41k33	6	45	amplifying	amplify	VERB
mp48sb41k33	6	46	the	the	DET
mp48sb41k33	6	47	cn	cn	PROPN
mp48sb41k33	6	48	in	in	ADP
mp48sb41k33	6	49	hb3	hb3	NUM
mp48sb41k33	6	50	parasites	parasite	NOUN
mp48sb41k33	6	51	(	(	PUNCT
mp48sb41k33	6	52	a	a	DET
mp48sb41k33	6	53	two	two	NUM
mp48sb41k33	6	54	-	-	ADJ
mp48sb41k33	6	55	fold	fold	ADJ
mp48sb41k33	6	56	increase	increase	NOUN
mp48sb41k33	6	57	)	)	PUNCT
mp48sb41k33	6	58	using	use	VERB
mp48sb41k33	6	59	the	the	DET
mp48sb41k33	6	60	piggybac	piggybac	NOUN
mp48sb41k33	6	61	transfection	transfection	NOUN
mp48sb41k33	6	62	system	system	NOUN
mp48sb41k33	6	63	.	.	PUNCT
mp48sb41k33	7	1	our	our	PRON
mp48sb41k33	7	2	data	datum	NOUN
mp48sb41k33	7	3	raise	raise	VERB
mp48sb41k33	7	4	the	the	DET
mp48sb41k33	7	5	interesting	interesting	ADJ
mp48sb41k33	7	6	possibility	possibility	NOUN
mp48sb41k33	7	7	that	that	SCONJ
mp48sb41k33	7	8	the	the	DET
mp48sb41k33	7	9	genetic	genetic	ADJ
mp48sb41k33	7	10	background	background	NOUN
mp48sb41k33	7	11	of	of	ADP
mp48sb41k33	7	12	resistant	resistant	ADJ
mp48sb41k33	7	13	parasites	parasite	NOUN
mp48sb41k33	7	14	,	,	PUNCT
mp48sb41k33	7	15	specifically	specifically	ADV
mp48sb41k33	7	16	dihydrofolate	dihydrofolate	NOUN
mp48sb41k33	7	17	reductase	reductase	NOUN
mp48sb41k33	7	18	(	(	PUNCT
mp48sb41k33	7	19	dhfr	dhfr	NOUN
mp48sb41k33	7	20	)	)	PUNCT
mp48sb41k33	7	21	mutation	mutation	NOUN
mp48sb41k33	7	22	background	background	NOUN
mp48sb41k33	7	23	,	,	PUNCT
mp48sb41k33	7	24	influences	influence	VERB
mp48sb41k33	7	25	the	the	DET
mp48sb41k33	7	26	magnitude	magnitude	NOUN
mp48sb41k33	7	27	of	of	ADP
mp48sb41k33	7	28	effect	effect	NOUN
mp48sb41k33	7	29	of	of	ADP
mp48sb41k33	7	30	gch1	gch1	PROPN
mp48sb41k33	7	31	cnv	cnv	PROPN
mp48sb41k33	7	32	on	on	ADP
mp48sb41k33	7	33	parasite	parasite	ADJ
mp48sb41k33	7	34	drug	drug	NOUN
mp48sb41k33	7	35	response	response	NOUN
mp48sb41k33	7	36	.	.	PUNCT
mp48sb41k33	8	1	previously	previously	ADV
mp48sb41k33	8	2	,	,	PUNCT
mp48sb41k33	8	3	cnvs	cnvs	PROPN
mp48sb41k33	8	4	have	have	AUX
mp48sb41k33	8	5	been	be	AUX
mp48sb41k33	8	6	associated	associate	VERB
mp48sb41k33	8	7	with	with	ADP
mp48sb41k33	8	8	resistance	resistance	NOUN
mp48sb41k33	8	9	levels	level	NOUN
mp48sb41k33	8	10	in	in	ADP
mp48sb41k33	8	11	natural	natural	ADJ
mp48sb41k33	8	12	parasite	parasite	NOUN
mp48sb41k33	8	13	populations	population	NOUN
mp48sb41k33	8	14	,	,	PUNCT
mp48sb41k33	8	15	however	however	ADV
mp48sb41k33	8	16	evidence	evidence	NOUN
mp48sb41k33	8	17	for	for	ADP
mp48sb41k33	8	18	their	their	PRON
mp48sb41k33	8	19	direct	direct	ADJ
mp48sb41k33	8	20	impact	impact	NOUN
mp48sb41k33	8	21	on	on	ADP
mp48sb41k33	8	22	drug	drug	NOUN
mp48sb41k33	8	23	-	-	PUNCT
mp48sb41k33	8	24	related	relate	VERB
mp48sb41k33	8	25	traits	trait	NOUN
mp48sb41k33	8	26	was	be	AUX
mp48sb41k33	8	27	lacking	lack	VERB
mp48sb41k33	8	28	.	.	PUNCT
mp48sb41k33	9	1	a	a	DET
mp48sb41k33	9	2	key	key	ADJ
mp48sb41k33	9	3	outcome	outcome	NOUN
mp48sb41k33	9	4	of	of	ADP
mp48sb41k33	9	5	this	this	DET
mp48sb41k33	9	6	project	project	NOUN
mp48sb41k33	9	7	was	be	AUX
mp48sb41k33	9	8	the	the	DET
mp48sb41k33	9	9	development	development	NOUN
mp48sb41k33	9	10	of	of	ADP
mp48sb41k33	9	11	approaches	approach	NOUN
mp48sb41k33	9	12	for	for	ADP
mp48sb41k33	9	13	the	the	DET
mp48sb41k33	9	14	continued	continue	VERB
mp48sb41k33	9	15	study	study	NOUN
mp48sb41k33	9	16	of	of	ADP
mp48sb41k33	9	17	the	the	DET
mp48sb41k33	9	18	gch1	gch1	PROPN
mp48sb41k33	9	19	cn	cn	PROPN
mp48sb41k33	9	20	phenotype	phenotype	PROPN
mp48sb41k33	9	21	.	.	PUNCT
mp48sb41k33	10	1	new	new	ADJ
mp48sb41k33	10	2	transfected	transfecte	VERB
mp48sb41k33	10	3	parasites	parasite	NOUN
mp48sb41k33	10	4	are	be	AUX
mp48sb41k33	10	5	already	already	ADV
mp48sb41k33	10	6	being	be	AUX
mp48sb41k33	10	7	produced	produce	VERB
mp48sb41k33	10	8	to	to	PART
mp48sb41k33	10	9	further	far	ADV
mp48sb41k33	10	10	explore	explore	VERB
mp48sb41k33	10	11	the	the	DET
mp48sb41k33	10	12	role	role	NOUN
mp48sb41k33	10	13	of	of	ADP
mp48sb41k33	10	14	dhfr	dhfr	NOUN
mp48sb41k33	10	15	background	background	NOUN
mp48sb41k33	10	16	mutations	mutation	NOUN
mp48sb41k33	10	17	.	.	PUNCT
mp48sb41k33	11	1	we	we	PRON
mp48sb41k33	11	2	have	have	AUX
mp48sb41k33	11	3	also	also	ADV
mp48sb41k33	11	4	developed	develop	VERB
mp48sb41k33	11	5	a	a	DET
mp48sb41k33	11	6	multiple	multiple	ADJ
mp48sb41k33	11	7	-	-	PUNCT
mp48sb41k33	11	8	reaction	reaction	NOUN
mp48sb41k33	11	9	monitoring	monitoring	NOUN
mp48sb41k33	11	10	massspectroscopy	massspectroscopy	VERB
mp48sb41k33	11	11	assay	assay	NOUN
mp48sb41k33	11	12	to	to	PART
mp48sb41k33	11	13	measure	measure	VERB
mp48sb41k33	11	14	changes	change	NOUN
mp48sb41k33	11	15	in	in	ADP
mp48sb41k33	11	16	flux	flux	NOUN
mp48sb41k33	11	17	of	of	ADP
mp48sb41k33	11	18	the	the	DET
mp48sb41k33	11	19	folate	folate	NOUN
mp48sb41k33	11	20	biosynthesis	biosynthesis	NOUN
mp48sb41k33	11	21	pathway	pathway	NOUN
mp48sb41k33	11	22	caused	cause	VERB
mp48sb41k33	11	23	by	by	ADP
mp48sb41k33	11	24	the	the	DET
mp48sb41k33	11	25	gch1	gch1	PROPN
mp48sb41k33	11	26	amplification	amplification	NOUN
mp48sb41k33	11	27	.	.	PUNCT
mp48sb41k33	12	1	this	this	DET
mp48sb41k33	12	2	method	method	NOUN
mp48sb41k33	12	3	will	will	AUX
mp48sb41k33	12	4	enable	enable	VERB
mp48sb41k33	12	5	experiments	experiment	NOUN
mp48sb41k33	12	6	to	to	PART
mp48sb41k33	12	7	determine	determine	VERB
mp48sb41k33	12	8	the	the	DET
mp48sb41k33	12	9	mechanism	mechanism	NOUN
mp48sb41k33	12	10	by	by	ADP
mp48sb41k33	12	11	which	which	PRON
mp48sb41k33	12	12	gch1	gch1	NOUN
mp48sb41k33	12	13	amplification	amplification	NOUN
mp48sb41k33	12	14	we	we	PRON
mp48sb41k33	12	15	leads	lead	VERB
mp48sb41k33	12	16	to	to	ADP
mp48sb41k33	12	17	shifts	shift	NOUN
mp48sb41k33	12	18	in	in	ADP
mp48sb41k33	12	19	drug	drug	NOUN
mp48sb41k33	12	20	susceptibility	susceptibility	NOUN
mp48sb41k33	12	21	.	.	PUNCT