id sid tid token lemma pos mp48sb41j8h 1 1 soy soy NOUN mp48sb41j8h 1 2 consumption consumption NOUN mp48sb41j8h 1 3 is be AUX mp48sb41j8h 1 4 known know VERB mp48sb41j8h 1 5 to to PART mp48sb41j8h 1 6 reduce reduce VERB mp48sb41j8h 1 7 serum serum NOUN mp48sb41j8h 1 8 cholesterol cholesterol NOUN mp48sb41j8h 1 9 levels level NOUN mp48sb41j8h 1 10 , , PUNCT mp48sb41j8h 1 11 thereby thereby ADV mp48sb41j8h 1 12 decreasing decrease VERB mp48sb41j8h 1 13 the the DET mp48sb41j8h 1 14 risk risk NOUN mp48sb41j8h 1 15 of of ADP mp48sb41j8h 1 16 cardiovascular cardiovascular ADJ mp48sb41j8h 1 17 disease disease NOUN mp48sb41j8h 1 18 . . PUNCT mp48sb41j8h 2 1 however however ADV mp48sb41j8h 2 2 , , PUNCT mp48sb41j8h 2 3 the the DET mp48sb41j8h 2 4 physiological physiological ADJ mp48sb41j8h 2 5 mechanisms mechanism NOUN mp48sb41j8h 2 6 and and CCONJ mp48sb41j8h 2 7 the the DET mp48sb41j8h 2 8 components component NOUN mp48sb41j8h 2 9 of of ADP mp48sb41j8h 2 10 soy soy NOUN mp48sb41j8h 2 11 that that PRON mp48sb41j8h 2 12 are be AUX mp48sb41j8h 2 13 responsible responsible ADJ mp48sb41j8h 2 14 for for ADP mp48sb41j8h 2 15 this this DET mp48sb41j8h 2 16 effect effect NOUN mp48sb41j8h 2 17 are be AUX mp48sb41j8h 2 18 not not PART mp48sb41j8h 2 19 known know VERB mp48sb41j8h 2 20 . . PUNCT mp48sb41j8h 3 1 it it PRON mp48sb41j8h 3 2 is be AUX mp48sb41j8h 3 3 our our PRON mp48sb41j8h 3 4 hypothesis hypothesis NOUN mp48sb41j8h 3 5 that that SCONJ mp48sb41j8h 3 6 the the DET mp48sb41j8h 3 7 hypocholesterolemic hypocholesterolemic ADJ mp48sb41j8h 3 8 effects effect NOUN mp48sb41j8h 3 9 of of ADP mp48sb41j8h 3 10 soy soy NOUN mp48sb41j8h 3 11 are be AUX mp48sb41j8h 3 12 mediated mediate VERB mp48sb41j8h 3 13 at at ADP mp48sb41j8h 3 14 least least ADJ mp48sb41j8h 3 15 in in ADP mp48sb41j8h 3 16 part part NOUN mp48sb41j8h 3 17 by by ADP mp48sb41j8h 3 18 isoflavone isoflavone NOUN mp48sb41j8h 3 19 - - PUNCT mp48sb41j8h 3 20 mediated mediate VERB mp48sb41j8h 3 21 regulation regulation NOUN mp48sb41j8h 3 22 of of ADP mp48sb41j8h 3 23 the the DET mp48sb41j8h 3 24 sterol sterol NOUN mp48sb41j8h 3 25 regulatory regulatory ADJ mp48sb41j8h 3 26 element element NOUN mp48sb41j8h 3 27 binding bind VERB mp48sb41j8h 3 28 proteins protein NOUN mp48sb41j8h 3 29 ( ( PUNCT mp48sb41j8h 3 30 srebps srebps NOUN mp48sb41j8h 3 31 ) ) PUNCT mp48sb41j8h 3 32 and and CCONJ mp48sb41j8h 3 33 the the DET mp48sb41j8h 3 34 sterol sterol PROPN mp48sb41j8h 3 35 regulatory regulatory PROPN mp48sb41j8h 3 36 element(sre element(sre NOUN mp48sb41j8h 3 37 ) ) PUNCT mp48sb41j8h 3 38 regulated regulate VERB mp48sb41j8h 3 39 genes gene NOUN mp48sb41j8h 3 40 . . PUNCT mp48sb41j8h 4 1 in in ADP mp48sb41j8h 4 2 hepg2 hepg2 ADJ mp48sb41j8h 4 3 cells cell NOUN mp48sb41j8h 4 4 exposed expose VERB mp48sb41j8h 4 5 to to ADP mp48sb41j8h 4 6 isoflavones isoflavone NOUN mp48sb41j8h 4 7 , , PUNCT mp48sb41j8h 4 8 an an DET mp48sb41j8h 4 9 increase increase NOUN mp48sb41j8h 4 10 in in ADP mp48sb41j8h 4 11 the the DET mp48sb41j8h 4 12 mature mature ADJ mp48sb41j8h 4 13 form form NOUN mp48sb41j8h 4 14 of of ADP mp48sb41j8h 4 15 srebp-2 srebp-2 PROPN mp48sb41j8h 4 16 and and CCONJ mp48sb41j8h 4 17 a a DET mp48sb41j8h 4 18 corresponding corresponding ADJ mp48sb41j8h 4 19 increase increase NOUN mp48sb41j8h 4 20 in in ADP mp48sb41j8h 4 21 the the DET mp48sb41j8h 4 22 expression expression NOUN mp48sb41j8h 4 23 of of ADP mp48sb41j8h 4 24 the the DET mp48sb41j8h 4 25 sre sre NOUN mp48sb41j8h 4 26 - - PUNCT mp48sb41j8h 4 27 regulated regulate VERB mp48sb41j8h 4 28 genes gene NOUN mp48sb41j8h 4 29 hmgcr hmgcr NOUN mp48sb41j8h 4 30 , , PUNCT mp48sb41j8h 4 31 hmg hmg PROPN mp48sb41j8h 4 32 coa coa NOUN mp48sb41j8h 4 33 synthase synthase NOUN mp48sb41j8h 4 34 and and CCONJ mp48sb41j8h 4 35 the the DET mp48sb41j8h 4 36 ldl ldl NOUN mp48sb41j8h 4 37 receptor receptor NOUN mp48sb41j8h 4 38 was be AUX mp48sb41j8h 4 39 observed observe VERB mp48sb41j8h 4 40 . . PUNCT mp48sb41j8h 5 1 the the DET mp48sb41j8h 5 2 observed observed ADJ mp48sb41j8h 5 3 isoflavone isoflavone NOUN mp48sb41j8h 5 4 - - PUNCT mp48sb41j8h 5 5 mediated mediate VERB mp48sb41j8h 5 6 increase increase NOUN mp48sb41j8h 5 7 was be AUX mp48sb41j8h 5 8 found find VERB mp48sb41j8h 5 9 to to PART mp48sb41j8h 5 10 be be AUX mp48sb41j8h 5 11 blunted blunt VERB mp48sb41j8h 5 12 by by ADP mp48sb41j8h 5 13 the the DET mp48sb41j8h 5 14 presence presence NOUN mp48sb41j8h 5 15 of of ADP mp48sb41j8h 5 16 cholesterol cholesterol NOUN mp48sb41j8h 5 17 . . PUNCT mp48sb41j8h 6 1 to to PART mp48sb41j8h 6 2 see see VERB mp48sb41j8h 6 3 if if SCONJ mp48sb41j8h 6 4 similar similar ADJ mp48sb41j8h 6 5 results result NOUN mp48sb41j8h 6 6 could could AUX mp48sb41j8h 6 7 be be AUX mp48sb41j8h 6 8 observed observe VERB mp48sb41j8h 6 9 in in ADP mp48sb41j8h 6 10 vivo vivo PROPN mp48sb41j8h 6 11 , , PUNCT mp48sb41j8h 6 12 we we PRON mp48sb41j8h 6 13 carried carry VERB mp48sb41j8h 6 14 out out ADP mp48sb41j8h 6 15 a a DET mp48sb41j8h 6 16 10 10 NUM mp48sb41j8h 6 17 day day NOUN mp48sb41j8h 6 18 soy soy NOUN mp48sb41j8h 6 19 feeding feeding NOUN mp48sb41j8h 6 20 study study NOUN mp48sb41j8h 6 21 in in ADP mp48sb41j8h 6 22 c57bl/6j c57bl/6j PROPN mp48sb41j8h 6 23 mice mouse NOUN mp48sb41j8h 6 24 . . PUNCT mp48sb41j8h 7 1 male male ADJ mp48sb41j8h 7 2 mice mouse NOUN mp48sb41j8h 7 3 fed feed VERB mp48sb41j8h 7 4 isoflavone isoflavone NOUN mp48sb41j8h 7 5 - - PUNCT mp48sb41j8h 7 6 containing contain VERB mp48sb41j8h 7 7 soy soy NOUN mp48sb41j8h 7 8 exhibited exhibit VERB mp48sb41j8h 7 9 enhanced enhance VERB mp48sb41j8h 7 10 decreases decrease NOUN mp48sb41j8h 7 11 in in ADP mp48sb41j8h 7 12 serum serum NOUN mp48sb41j8h 7 13 lipid lipid NOUN mp48sb41j8h 7 14 levels level NOUN mp48sb41j8h 7 15 compared compare VERB mp48sb41j8h 7 16 to to ADP mp48sb41j8h 7 17 female female ADJ mp48sb41j8h 7 18 mice mouse NOUN mp48sb41j8h 7 19 . . PUNCT mp48sb41j8h 8 1 while while SCONJ mp48sb41j8h 8 2 there there PRON mp48sb41j8h 8 3 was be VERB mp48sb41j8h 8 4 a a DET mp48sb41j8h 8 5 slight slight ADJ mp48sb41j8h 8 6 increase increase NOUN mp48sb41j8h 8 7 in in ADP mp48sb41j8h 8 8 hepatic hepatic PROPN mp48sb41j8h 8 9 srebp-2 srebp-2 PROPN mp48sb41j8h 8 10 protein protein NOUN mp48sb41j8h 8 11 levels level NOUN mp48sb41j8h 8 12 in in ADP mp48sb41j8h 8 13 isoflavone isoflavone PROPN mp48sb41j8h 8 14 fed fed PROPN mp48sb41j8h 8 15 mice mouse NOUN mp48sb41j8h 8 16 , , PUNCT mp48sb41j8h 8 17 there there PRON mp48sb41j8h 8 18 was be VERB mp48sb41j8h 8 19 no no DET mp48sb41j8h 8 20 effect effect NOUN mp48sb41j8h 8 21 on on ADP mp48sb41j8h 8 22 sre sre NOUN mp48sb41j8h 8 23 - - PUNCT mp48sb41j8h 8 24 regulated regulate VERB mp48sb41j8h 8 25 gene gene NOUN mp48sb41j8h 8 26 expression expression NOUN mp48sb41j8h 8 27 . . PUNCT mp48sb41j8h 9 1 we we PRON mp48sb41j8h 9 2 then then ADV mp48sb41j8h 9 3 investigated investigate VERB mp48sb41j8h 9 4 the the DET mp48sb41j8h 9 5 mechanism mechanism NOUN mp48sb41j8h 9 6 by by ADP mp48sb41j8h 9 7 which which PRON mp48sb41j8h 9 8 the the DET mp48sb41j8h 9 9 isoflavones isoflavone NOUN mp48sb41j8h 9 10 upregulated upregulate VERB mp48sb41j8h 9 11 srebp srebp PROPN mp48sb41j8h 9 12 and and CCONJ mp48sb41j8h 9 13 sre sre NOUN mp48sb41j8h 9 14 - - PUNCT mp48sb41j8h 9 15 regulated regulate VERB mp48sb41j8h 9 16 genes gene NOUN mp48sb41j8h 9 17 in in ADP mp48sb41j8h 9 18 vitro vitro X mp48sb41j8h 9 19 . . PUNCT mp48sb41j8h 10 1 in in ADP mp48sb41j8h 10 2 vitro vitro X mp48sb41j8h 10 3 , , PUNCT mp48sb41j8h 10 4 genistein genistein PROPN mp48sb41j8h 10 5 acted act VERB mp48sb41j8h 10 6 as as ADP mp48sb41j8h 10 7 a a DET mp48sb41j8h 10 8 proteasome proteasome NOUN mp48sb41j8h 10 9 inhibitor inhibitor NOUN mp48sb41j8h 10 10 but but CCONJ mp48sb41j8h 10 11 daidzein daidzein PROPN mp48sb41j8h 10 12 did do VERB mp48sb41j8h 10 13 not not PART mp48sb41j8h 10 14 . . PUNCT mp48sb41j8h 11 1 genistein genistein PROPN mp48sb41j8h 11 2 also also ADV mp48sb41j8h 11 3 increased increase VERB mp48sb41j8h 11 4 phosphorylation phosphorylation NOUN mp48sb41j8h 11 5 of of ADP mp48sb41j8h 11 6 hmgcr hmgcr NOUN mp48sb41j8h 11 7 , , PUNCT mp48sb41j8h 11 8 a a DET mp48sb41j8h 11 9 modification modification NOUN mp48sb41j8h 11 10 associated associate VERB mp48sb41j8h 11 11 with with ADP mp48sb41j8h 11 12 reduced reduce VERB mp48sb41j8h 11 13 enzymatic enzymatic ADJ mp48sb41j8h 11 14 action action NOUN mp48sb41j8h 11 15 . . PUNCT mp48sb41j8h 12 1 daidzein daidzein PROPN mp48sb41j8h 12 2 did do AUX mp48sb41j8h 12 3 not not PART mp48sb41j8h 12 4 increase increase VERB mp48sb41j8h 12 5 phosphorylation phosphorylation NOUN mp48sb41j8h 12 6 of of ADP mp48sb41j8h 12 7 hmgcr hmgcr NOUN mp48sb41j8h 12 8 in in ADP mp48sb41j8h 12 9 preliminary preliminary ADJ mp48sb41j8h 12 10 studies study NOUN mp48sb41j8h 12 11 . . PUNCT mp48sb41j8h 13 1 in in ADP mp48sb41j8h 13 2 conclustion conclustion NOUN mp48sb41j8h 13 3 , , PUNCT mp48sb41j8h 13 4 isoflavones isoflavone NOUN mp48sb41j8h 13 5 may may AUX mp48sb41j8h 13 6 be be AUX mp48sb41j8h 13 7 increasing increase VERB mp48sb41j8h 13 8 srebp srebp PROPN mp48sb41j8h 13 9 and and CCONJ mp48sb41j8h 13 10 sre sre NOUN mp48sb41j8h 13 11 - - PUNCT mp48sb41j8h 13 12 regulated regulate VERB mp48sb41j8h 13 13 genes gene NOUN mp48sb41j8h 13 14 in in ADP mp48sb41j8h 13 15 vitro vitro X mp48sb41j8h 13 16 but but CCONJ mp48sb41j8h 13 17 they they PRON mp48sb41j8h 13 18 do do AUX mp48sb41j8h 13 19 not not PART mp48sb41j8h 13 20 appear appear VERB mp48sb41j8h 13 21 to to PART mp48sb41j8h 13 22 have have VERB mp48sb41j8h 13 23 the the DET mp48sb41j8h 13 24 same same ADJ mp48sb41j8h 13 25 effect effect NOUN mp48sb41j8h 13 26 in in ADP mp48sb41j8h 13 27 vivo vivo PROPN mp48sb41j8h 13 28 . . PUNCT mp48sb41j8h 14 1 most most ADV mp48sb41j8h 14 2 likely likely ADJ mp48sb41j8h 14 3 , , PUNCT mp48sb41j8h 14 4 there there PRON mp48sb41j8h 14 5 are be VERB mp48sb41j8h 14 6 multiple multiple ADJ mp48sb41j8h 14 7 mechanisms mechanism NOUN mp48sb41j8h 14 8 by by ADP mp48sb41j8h 14 9 which which PRON mp48sb41j8h 14 10 the the DET mp48sb41j8h 14 11 increase increase NOUN mp48sb41j8h 14 12 is be AUX mp48sb41j8h 14 13 caused cause VERB mp48sb41j8h 14 14 ; ; PUNCT mp48sb41j8h 14 15 genistein genistein PROPN mp48sb41j8h 14 16 and and CCONJ mp48sb41j8h 14 17 daidzein daidzein PROPN mp48sb41j8h 14 18 may may AUX mp48sb41j8h 14 19 act act VERB mp48sb41j8h 14 20 by by ADP mp48sb41j8h 14 21 different different ADJ mp48sb41j8h 14 22 mechanisms mechanism NOUN mp48sb41j8h 14 23 . . PUNCT