id	sid	tid	token	lemma	pos
mc87pn91r8k	1	1	octopamine	octopamine	NOUN
mc87pn91r8k	1	2	receptors	receptor	NOUN
mc87pn91r8k	1	3	(	(	PUNCT
mc87pn91r8k	1	4	oars	oar	NOUN
mc87pn91r8k	1	5	)	)	PUNCT
mc87pn91r8k	1	6	perform	perform	VERB
mc87pn91r8k	1	7	key	key	ADJ
mc87pn91r8k	1	8	operations	operation	NOUN
mc87pn91r8k	1	9	in	in	ADP
mc87pn91r8k	1	10	the	the	DET
mc87pn91r8k	1	11	biological	biological	ADJ
mc87pn91r8k	1	12	pathways	pathway	NOUN
mc87pn91r8k	1	13	of	of	ADP
mc87pn91r8k	1	14	invertebrates	invertebrate	NOUN
mc87pn91r8k	1	15	only	only	ADV
mc87pn91r8k	1	16	,	,	PUNCT
mc87pn91r8k	1	17	making	make	VERB
mc87pn91r8k	1	18	this	this	DET
mc87pn91r8k	1	19	class	class	NOUN
mc87pn91r8k	1	20	of	of	ADP
mc87pn91r8k	1	21	g	g	NOUN
mc87pn91r8k	1	22	-	-	PUNCT
mc87pn91r8k	1	23	protein	protein	NOUN
mc87pn91r8k	1	24	coupled	couple	VERB
mc87pn91r8k	1	25	receptors	receptor	NOUN
mc87pn91r8k	1	26	(	(	PUNCT
mc87pn91r8k	1	27	gpcrs	gpcrs	PROPN
mc87pn91r8k	1	28	)	)	PUNCT
mc87pn91r8k	1	29	a	a	DET
mc87pn91r8k	1	30	potentially	potentially	ADV
mc87pn91r8k	1	31	good	good	ADJ
mc87pn91r8k	1	32	target	target	NOUN
mc87pn91r8k	1	33	for	for	ADP
mc87pn91r8k	1	34	insecticides	insecticide	NOUN
mc87pn91r8k	1	35	.	.	PUNCT
mc87pn91r8k	2	1	however	however	ADV
mc87pn91r8k	2	2	,	,	PUNCT
mc87pn91r8k	2	3	the	the	DET
mc87pn91r8k	2	4	lack	lack	NOUN
mc87pn91r8k	2	5	of	of	ADP
mc87pn91r8k	2	6	structural	structural	ADJ
mc87pn91r8k	2	7	and	and	CCONJ
mc87pn91r8k	2	8	experimental	experimental	ADJ
mc87pn91r8k	2	9	data	datum	NOUN
mc87pn91r8k	2	10	for	for	ADP
mc87pn91r8k	2	11	this	this	DET
mc87pn91r8k	2	12	insect	insect	NOUN
mc87pn91r8k	2	13	-	-	PUNCT
mc87pn91r8k	2	14	essential	essential	ADJ
mc87pn91r8k	2	15	gpcr	gpcr	ADJ
mc87pn91r8k	2	16	class	class	NOUN
mc87pn91r8k	2	17	has	have	AUX
mc87pn91r8k	2	18	promoted	promote	VERB
mc87pn91r8k	2	19	the	the	DET
mc87pn91r8k	2	20	development	development	NOUN
mc87pn91r8k	2	21	of	of	ADP
mc87pn91r8k	2	22	homology	homology	NOUN
mc87pn91r8k	2	23	models	model	NOUN
mc87pn91r8k	2	24	that	that	PRON
mc87pn91r8k	2	25	are	be	AUX
mc87pn91r8k	2	26	good	good	ADJ
mc87pn91r8k	2	27	representations	representation	NOUN
mc87pn91r8k	2	28	of	of	ADP
mc87pn91r8k	2	29	their	their	PRON
mc87pn91r8k	2	30	biological	biological	ADJ
mc87pn91r8k	2	31	equivalents	equivalent	NOUN
mc87pn91r8k	2	32	and	and	CCONJ
mc87pn91r8k	2	33	will	will	AUX
mc87pn91r8k	2	34	thus	thus	ADV
mc87pn91r8k	2	35	be	be	AUX
mc87pn91r8k	2	36	useful	useful	ADJ
mc87pn91r8k	2	37	in	in	ADP
mc87pn91r8k	2	38	the	the	DET
mc87pn91r8k	2	39	development	development	NOUN
mc87pn91r8k	2	40	of	of	ADP
mc87pn91r8k	2	41	an	an	DET
mc87pn91r8k	2	42	insecticide	insecticide	NOUN
mc87pn91r8k	2	43	.	.	PUNCT
mc87pn91r8k	3	1	i	i	PRON
mc87pn91r8k	3	2	report	report	VERB
mc87pn91r8k	3	3	here	here	ADV
mc87pn91r8k	3	4	the	the	DET
mc87pn91r8k	3	5	functional	functional	ADJ
mc87pn91r8k	3	6	characterization	characterization	NOUN
mc87pn91r8k	3	7	of	of	ADP
mc87pn91r8k	3	8	two	two	NUM
mc87pn91r8k	3	9	anopheles	anophele	NOUN
mc87pn91r8k	3	10	gambiae	gambiae	NOUN
mc87pn91r8k	3	11	oars	oar	NOUN
mc87pn91r8k	3	12	and	and	CCONJ
mc87pn91r8k	3	13	the	the	DET
mc87pn91r8k	3	14	discovery	discovery	NOUN
mc87pn91r8k	3	15	of	of	ADP
mc87pn91r8k	3	16	new	new	ADJ
mc87pn91r8k	3	17	oar	oar	NOUN
mc87pn91r8k	3	18	agonists	agonist	NOUN
mc87pn91r8k	3	19	and	and	CCONJ
mc87pn91r8k	3	20	antagonists	antagonist	NOUN
mc87pn91r8k	3	21	based	base	VERB
mc87pn91r8k	3	22	on	on	ADP
mc87pn91r8k	3	23	virtual	virtual	ADJ
mc87pn91r8k	3	24	screening	screening	NOUN
mc87pn91r8k	3	25	and	and	CCONJ
mc87pn91r8k	3	26	molecular	molecular	ADJ
mc87pn91r8k	3	27	dynamics	dynamic	NOUN
mc87pn91r8k	3	28	(	(	PUNCT
mc87pn91r8k	3	29	md	md	PROPN
mc87pn91r8k	3	30	)	)	PUNCT
mc87pn91r8k	3	31	simulations	simulation	NOUN
mc87pn91r8k	3	32	.	.	PUNCT
mc87pn91r8k	4	1	experimental	experimental	ADJ
mc87pn91r8k	4	2	validation	validation	NOUN
mc87pn91r8k	4	3	of	of	ADP
mc87pn91r8k	4	4	the	the	DET
mc87pn91r8k	4	5	results	result	NOUN
mc87pn91r8k	4	6	shows	show	VERB
mc87pn91r8k	4	7	the	the	DET
mc87pn91r8k	4	8	accuracy	accuracy	NOUN
mc87pn91r8k	4	9	of	of	ADP
mc87pn91r8k	4	10	the	the	DET
mc87pn91r8k	4	11	model	model	NOUN
mc87pn91r8k	4	12	.	.	PUNCT
mc87pn91r8k	5	1	supporting	support	VERB
mc87pn91r8k	5	2	prior	prior	ADJ
mc87pn91r8k	5	3	gpcr	gpcr	ADJ
mc87pn91r8k	5	4	studies	study	NOUN
mc87pn91r8k	5	5	,	,	PUNCT
mc87pn91r8k	5	6	asp100	asp100	PROPN
mc87pn91r8k	5	7	in	in	ADP
mc87pn91r8k	5	8	the	the	DET
mc87pn91r8k	5	9	tm3	tm3	NOUN
mc87pn91r8k	5	10	region	region	NOUN
mc87pn91r8k	5	11	,	,	PUNCT
mc87pn91r8k	5	12	and	and	CCONJ
mc87pn91r8k	5	13	ser206	ser206	PROPN
mc87pn91r8k	5	14	and	and	CCONJ
mc87pn91r8k	5	15	ser210	ser210	PROPN
mc87pn91r8k	5	16	in	in	ADP
mc87pn91r8k	5	17	the	the	DET
mc87pn91r8k	5	18	tm5	tm5	NOUN
mc87pn91r8k	5	19	region	region	NOUN
mc87pn91r8k	5	20	were	be	AUX
mc87pn91r8k	5	21	found	find	VERB
mc87pn91r8k	5	22	to	to	PART
mc87pn91r8k	5	23	be	be	AUX
mc87pn91r8k	5	24	important	important	ADJ
mc87pn91r8k	5	25	to	to	ADP
mc87pn91r8k	5	26	the	the	DET
mc87pn91r8k	5	27	activation	activation	NOUN
mc87pn91r8k	5	28	of	of	ADP
mc87pn91r8k	5	29	the	the	DET
mc87pn91r8k	5	30	protein	protein	NOUN
mc87pn91r8k	5	31	.	.	PUNCT
mc87pn91r8k	6	1	the	the	DET
mc87pn91r8k	6	2	current	current	ADJ
mc87pn91r8k	6	3	combined	combined	ADJ
mc87pn91r8k	6	4	computational	computational	ADJ
mc87pn91r8k	6	5	and	and	CCONJ
mc87pn91r8k	6	6	experimental	experimental	ADJ
mc87pn91r8k	6	7	approach	approach	NOUN
mc87pn91r8k	6	8	seems	seem	VERB
mc87pn91r8k	6	9	appropriate	appropriate	ADJ
mc87pn91r8k	6	10	for	for	ADP
mc87pn91r8k	6	11	creating	create	VERB
mc87pn91r8k	6	12	and	and	CCONJ
mc87pn91r8k	6	13	refining	refining	NOUN
mc87pn91r8k	6	14	homology	homology	NOUN
mc87pn91r8k	6	15	models	model	NOUN
mc87pn91r8k	6	16	of	of	ADP
mc87pn91r8k	6	17	the	the	DET
mc87pn91r8k	6	18	octopamine	octopamine	ADJ
mc87pn91r8k	6	19	receptor	receptor	NOUN
mc87pn91r8k	6	20	and	and	CCONJ
mc87pn91r8k	6	21	in	in	ADP
mc87pn91r8k	6	22	turn	turn	NOUN
mc87pn91r8k	6	23	aid	aid	NOUN
mc87pn91r8k	6	24	in	in	ADP
mc87pn91r8k	6	25	the	the	DET
mc87pn91r8k	6	26	discovery	discovery	NOUN
mc87pn91r8k	6	27	of	of	ADP
mc87pn91r8k	6	28	new	new	ADJ
mc87pn91r8k	6	29	and	and	CCONJ
mc87pn91r8k	6	30	effective	effective	ADJ
mc87pn91r8k	6	31	insecticides.improvements	insecticides.improvement	NOUN
mc87pn91r8k	6	32	can	can	AUX
mc87pn91r8k	6	33	be	be	AUX
mc87pn91r8k	6	34	made	make	VERB
mc87pn91r8k	6	35	to	to	ADP
mc87pn91r8k	6	36	the	the	DET
mc87pn91r8k	6	37	virtual	virtual	ADJ
mc87pn91r8k	6	38	screening	screening	NOUN
mc87pn91r8k	6	39	procedure	procedure	NOUN
mc87pn91r8k	6	40	by	by	ADP
mc87pn91r8k	6	41	allowing	allow	VERB
mc87pn91r8k	6	42	the	the	DET
mc87pn91r8k	6	43	protein	protein	NOUN
mc87pn91r8k	6	44	to	to	PART
mc87pn91r8k	6	45	fully	fully	ADV
mc87pn91r8k	6	46	assume	assume	VERB
mc87pn91r8k	6	47	its	its	PRON
mc87pn91r8k	6	48	active	active	ADJ
mc87pn91r8k	6	49	and	and	CCONJ
mc87pn91r8k	6	50	inactive	inactive	ADJ
mc87pn91r8k	6	51	states	state	NOUN
mc87pn91r8k	6	52	.	.	PUNCT
mc87pn91r8k	7	1	however	however	ADV
mc87pn91r8k	7	2	,	,	PUNCT
mc87pn91r8k	7	3	gpcrs	gpcrs	PROPN
mc87pn91r8k	7	4	are	be	AUX
mc87pn91r8k	7	5	large	large	ADJ
mc87pn91r8k	7	6	proteins	protein	NOUN
mc87pn91r8k	7	7	,	,	PUNCT
mc87pn91r8k	7	8	are	be	AUX
mc87pn91r8k	7	9	suspended	suspend	VERB
mc87pn91r8k	7	10	in	in	ADP
mc87pn91r8k	7	11	a	a	DET
mc87pn91r8k	7	12	lipid	lipid	NOUN
mc87pn91r8k	7	13	bilayer	bilayer	NOUN
mc87pn91r8k	7	14	,	,	PUNCT
mc87pn91r8k	7	15	and	and	CCONJ
mc87pn91r8k	7	16	are	be	AUX
mc87pn91r8k	7	17	activated	activate	VERB
mc87pn91r8k	7	18	on	on	ADP
mc87pn91r8k	7	19	the	the	DET
mc87pn91r8k	7	20	millisecond	millisecond	NOUN
mc87pn91r8k	7	21	timescale	timescale	NOUN
mc87pn91r8k	7	22	,	,	PUNCT
mc87pn91r8k	7	23	all	all	PRON
mc87pn91r8k	7	24	of	of	ADP
mc87pn91r8k	7	25	which	which	PRON
mc87pn91r8k	7	26	make	make	VERB
mc87pn91r8k	7	27	conventional	conventional	ADJ
mc87pn91r8k	7	28	molecular	molecular	ADJ
mc87pn91r8k	7	29	dynamics	dynamic	NOUN
mc87pn91r8k	7	30	(	(	PUNCT
mc87pn91r8k	7	31	md	md	PROPN
mc87pn91r8k	7	32	)	)	PUNCT
mc87pn91r8k	7	33	simulations	simulation	NOUN
mc87pn91r8k	7	34	infeasible	infeasible	ADJ
mc87pn91r8k	7	35	,	,	PUNCT
mc87pn91r8k	7	36	even	even	ADV
mc87pn91r8k	7	37	if	if	SCONJ
mc87pn91r8k	7	38	run	run	VERB
mc87pn91r8k	7	39	on	on	ADP
mc87pn91r8k	7	40	large	large	ADJ
mc87pn91r8k	7	41	supercomputers	supercomputer	NOUN
mc87pn91r8k	7	42	.	.	PUNCT
mc87pn91r8k	8	1	however	however	ADV
mc87pn91r8k	8	2	,	,	PUNCT
mc87pn91r8k	8	3	accelerated	accelerate	VERB
mc87pn91r8k	8	4	molecular	molecular	ADJ
mc87pn91r8k	8	5	dynamics	dynamic	NOUN
mc87pn91r8k	8	6	(	(	PUNCT
mc87pn91r8k	8	7	amd	amd	PROPN
mc87pn91r8k	8	8	)	)	PUNCT
mc87pn91r8k	8	9	simulations	simulation	NOUN
mc87pn91r8k	8	10	can	can	AUX
mc87pn91r8k	8	11	reduce	reduce	VERB
mc87pn91r8k	8	12	this	this	DET
mc87pn91r8k	8	13	timescale	timescale	NOUN
mc87pn91r8k	8	14	to	to	ADP
mc87pn91r8k	8	15	even	even	ADV
mc87pn91r8k	8	16	hundreds	hundred	NOUN
mc87pn91r8k	8	17	of	of	ADP
mc87pn91r8k	8	18	nanoseconds	nanosecond	NOUN
mc87pn91r8k	8	19	,	,	PUNCT
mc87pn91r8k	8	20	while	while	SCONJ
mc87pn91r8k	8	21	running	run	VERB
mc87pn91r8k	8	22	the	the	DET
mc87pn91r8k	8	23	simulations	simulation	NOUN
mc87pn91r8k	8	24	on	on	ADP
mc87pn91r8k	8	25	graphics	graphic	NOUN
mc87pn91r8k	8	26	processing	processing	NOUN
mc87pn91r8k	8	27	units	unit	NOUN
mc87pn91r8k	8	28	(	(	PUNCT
mc87pn91r8k	8	29	gpus	gpus	X
mc87pn91r8k	8	30	)	)	PUNCT
mc87pn91r8k	8	31	would	would	AUX
mc87pn91r8k	8	32	enable	enable	VERB
mc87pn91r8k	8	33	even	even	ADV
mc87pn91r8k	8	34	small	small	ADJ
mc87pn91r8k	8	35	clusters	cluster	NOUN
mc87pn91r8k	8	36	of	of	ADP
mc87pn91r8k	8	37	gpus	gpus	PROPN
mc87pn91r8k	8	38	to	to	PART
mc87pn91r8k	8	39	have	have	VERB
mc87pn91r8k	8	40	processing	processing	NOUN
mc87pn91r8k	8	41	power	power	NOUN
mc87pn91r8k	8	42	equivalent	equivalent	ADJ
mc87pn91r8k	8	43	to	to	ADP
mc87pn91r8k	8	44	hundreds	hundred	NOUN
mc87pn91r8k	8	45	of	of	ADP
mc87pn91r8k	8	46	cpus	cpu	NOUN
mc87pn91r8k	8	47	.	.	PUNCT
mc87pn91r8k	9	1	my	my	PRON
mc87pn91r8k	9	2	results	result	NOUN
mc87pn91r8k	9	3	show	show	VERB
mc87pn91r8k	9	4	that	that	SCONJ
mc87pn91r8k	9	5	amd	amd	NOUN
mc87pn91r8k	9	6	simulations	simulation	NOUN
mc87pn91r8k	9	7	run	run	VERB
mc87pn91r8k	9	8	on	on	ADP
mc87pn91r8k	9	9	gpus	gpu	NOUN
mc87pn91r8k	9	10	can	can	AUX
mc87pn91r8k	9	11	successfully	successfully	ADV
mc87pn91r8k	9	12	obtain	obtain	VERB
mc87pn91r8k	9	13	the	the	DET
mc87pn91r8k	9	14	active	active	ADJ
mc87pn91r8k	9	15	and	and	CCONJ
mc87pn91r8k	9	16	inactive	inactive	ADJ
mc87pn91r8k	9	17	state	state	NOUN
mc87pn91r8k	9	18	conformations	conformation	NOUN
mc87pn91r8k	9	19	of	of	ADP
mc87pn91r8k	9	20	a	a	DET
mc87pn91r8k	9	21	gpcr	gpcr	NOUN
mc87pn91r8k	9	22	on	on	ADP
mc87pn91r8k	9	23	this	this	DET
mc87pn91r8k	9	24	reduced	reduce	VERB
mc87pn91r8k	9	25	timescale	timescale	NOUN
mc87pn91r8k	9	26	.	.	PUNCT
mc87pn91r8k	10	1	furthermore	furthermore	ADV
mc87pn91r8k	10	2	,	,	PUNCT
mc87pn91r8k	10	3	i	i	PRON
mc87pn91r8k	10	4	discovered	discover	VERB
mc87pn91r8k	10	5	a	a	DET
mc87pn91r8k	10	6	potential	potential	ADJ
mc87pn91r8k	10	7	alternate	alternate	ADJ
mc87pn91r8k	10	8	active	active	ADJ
mc87pn91r8k	10	9	-	-	PUNCT
mc87pn91r8k	10	10	state	state	NOUN
mc87pn91r8k	10	11	agonist	agonist	NOUN
mc87pn91r8k	10	12	-	-	PUNCT
mc87pn91r8k	10	13	binding	bind	VERB
mc87pn91r8k	10	14	position	position	NOUN
mc87pn91r8k	10	15	in	in	ADP
mc87pn91r8k	10	16	the	the	DET
mc87pn91r8k	10	17	octopamine	octopamine	ADJ
mc87pn91r8k	10	18	receptor	receptor	NOUN
mc87pn91r8k	10	19	which	which	PRON
mc87pn91r8k	10	20	has	have	VERB
mc87pn91r8k	10	21	yet	yet	ADV
mc87pn91r8k	10	22	to	to	PART
mc87pn91r8k	10	23	be	be	AUX
mc87pn91r8k	10	24	observed	observe	VERB
mc87pn91r8k	10	25	and	and	CCONJ
mc87pn91r8k	10	26	may	may	AUX
mc87pn91r8k	10	27	be	be	AUX
mc87pn91r8k	10	28	a	a	DET
mc87pn91r8k	10	29	novel	novel	ADJ
mc87pn91r8k	10	30	gpcr	gpcr	ADJ
mc87pn91r8k	10	31	agonist	agonist	NOUN
mc87pn91r8k	10	32	-	-	PUNCT
mc87pn91r8k	10	33	binding	bind	VERB
mc87pn91r8k	10	34	position	position	NOUN
mc87pn91r8k	10	35	.	.	PUNCT
mc87pn91r8k	11	1	these	these	DET
mc87pn91r8k	11	2	results	result	NOUN
mc87pn91r8k	11	3	demonstrate	demonstrate	VERB
mc87pn91r8k	11	4	that	that	SCONJ
mc87pn91r8k	11	5	a	a	DET
mc87pn91r8k	11	6	complex	complex	ADJ
mc87pn91r8k	11	7	biological	biological	ADJ
mc87pn91r8k	11	8	system	system	NOUN
mc87pn91r8k	11	9	with	with	ADP
mc87pn91r8k	11	10	an	an	DET
mc87pn91r8k	11	11	activation	activation	NOUN
mc87pn91r8k	11	12	process	process	NOUN
mc87pn91r8k	11	13	on	on	ADP
mc87pn91r8k	11	14	the	the	DET
mc87pn91r8k	11	15	millisecond	millisecond	NOUN
mc87pn91r8k	11	16	timescale	timescale	NOUN
mc87pn91r8k	11	17	can	can	AUX
mc87pn91r8k	11	18	be	be	AUX
mc87pn91r8k	11	19	successfully	successfully	ADV
mc87pn91r8k	11	20	simulated	simulate	VERB
mc87pn91r8k	11	21	on	on	ADP
mc87pn91r8k	11	22	the	the	DET
mc87pn91r8k	11	23	nanosecond	nanosecond	ADJ
mc87pn91r8k	11	24	timescale	timescale	NOUN
mc87pn91r8k	11	25	using	use	VERB
mc87pn91r8k	11	26	a	a	DET
mc87pn91r8k	11	27	simple	simple	ADJ
mc87pn91r8k	11	28	computing	computing	NOUN
mc87pn91r8k	11	29	system	system	NOUN
mc87pn91r8k	11	30	consisting	consist	VERB
mc87pn91r8k	11	31	of	of	ADP
mc87pn91r8k	11	32	a	a	DET
mc87pn91r8k	11	33	small	small	ADJ
mc87pn91r8k	11	34	number	number	NOUN
mc87pn91r8k	11	35	of	of	ADP
mc87pn91r8k	11	36	gpus	gpu	NOUN
mc87pn91r8k	11	37	.	.	PUNCT