id	sid	tid	token	lemma	pos
m326m042z67	1	1	niemann	niemann	PROPN
m326m042z67	1	2	pick	pick	PROPN
m326m042z67	1	3	type	type	PROPN
m326m042z67	1	4	c	c	PROPN
m326m042z67	1	5	(	(	PUNCT
m326m042z67	1	6	npc	npc	PROPN
m326m042z67	1	7	)	)	PUNCT
m326m042z67	1	8	disease	disease	NOUN
m326m042z67	1	9	is	be	AUX
m326m042z67	1	10	a	a	DET
m326m042z67	1	11	rare	rare	ADJ
m326m042z67	1	12	pediatric	pediatric	ADJ
m326m042z67	1	13	neurodegenerative	neurodegenerative	ADJ
m326m042z67	1	14	disorder	disorder	NOUN
m326m042z67	1	15	that	that	PRON
m326m042z67	1	16	primarily	primarily	ADV
m326m042z67	1	17	impacts	impact	VERB
m326m042z67	1	18	purkinje	purkinje	NOUN
m326m042z67	1	19	cells	cell	NOUN
m326m042z67	1	20	in	in	ADP
m326m042z67	1	21	the	the	DET
m326m042z67	1	22	cerebellum	cerebellum	NOUN
m326m042z67	1	23	.	.	PUNCT
m326m042z67	2	1	the	the	DET
m326m042z67	2	2	disease	disease	NOUN
m326m042z67	2	3	is	be	AUX
m326m042z67	2	4	an	an	DET
m326m042z67	2	5	autosomal	autosomal	NOUN
m326m042z67	2	6	recessive	recessive	ADJ
m326m042z67	2	7	disorder	disorder	NOUN
m326m042z67	2	8	caused	cause	VERB
m326m042z67	2	9	by	by	ADP
m326m042z67	2	10	point	point	NOUN
m326m042z67	2	11	mutations	mutation	NOUN
m326m042z67	2	12	on	on	ADP
m326m042z67	2	13	two	two	NUM
m326m042z67	2	14	cholesterol	cholesterol	NOUN
m326m042z67	2	15	-	-	PUNCT
m326m042z67	2	16	binding	bind	VERB
m326m042z67	2	17	proteins	protein	NOUN
m326m042z67	2	18	in	in	ADP
m326m042z67	2	19	the	the	DET
m326m042z67	2	20	lysosome	lysosome	NOUN
m326m042z67	2	21	:	:	PUNCT
m326m042z67	2	22	npc1	npc1	ADV
m326m042z67	2	23	and	and	CCONJ
m326m042z67	2	24	npc2	npc2	VERB
m326m042z67	2	25	.	.	PUNCT
m326m042z67	3	1	live	live	ADJ
m326m042z67	3	2	cell	cell	NOUN
m326m042z67	3	3	imaging	imaging	NOUN
m326m042z67	3	4	of	of	ADP
m326m042z67	3	5	npc1	npc1	PROPN
m326m042z67	3	6	mutations	mutation	NOUN
m326m042z67	3	7	revealed	reveal	VERB
m326m042z67	3	8	a	a	DET
m326m042z67	3	9	significant	significant	ADJ
m326m042z67	3	10	decrease	decrease	NOUN
m326m042z67	3	11	in	in	ADP
m326m042z67	3	12	lysosomal	lysosomal	NOUN
m326m042z67	3	13	tubulation	tubulation	NOUN
m326m042z67	3	14	,	,	PUNCT
m326m042z67	3	15	which	which	PRON
m326m042z67	3	16	is	be	AUX
m326m042z67	3	17	essential	essential	ADJ
m326m042z67	3	18	to	to	ADP
m326m042z67	3	19	cholesterol	cholesterol	NOUN
m326m042z67	3	20	transport	transport	NOUN
m326m042z67	3	21	.	.	PUNCT
m326m042z67	4	1	stard9	stard9	PROPN
m326m042z67	4	2	was	be	AUX
m326m042z67	4	3	recently	recently	ADV
m326m042z67	4	4	identified	identify	VERB
m326m042z67	4	5	as	as	ADP
m326m042z67	4	6	the	the	DET
m326m042z67	4	7	kinesin	kinesin	NOUN
m326m042z67	4	8	that	that	PRON
m326m042z67	4	9	drives	drive	VERB
m326m042z67	4	10	lysosomal	lysosomal	NOUN
m326m042z67	4	11	tubulation	tubulation	NOUN
m326m042z67	4	12	.	.	PUNCT
m326m042z67	5	1	similar	similar	ADJ
m326m042z67	5	2	to	to	ADP
m326m042z67	5	3	npc	npc	NOUN
m326m042z67	5	4	disease	disease	NOUN
m326m042z67	5	5	cells	cell	NOUN
m326m042z67	5	6	,	,	PUNCT
m326m042z67	5	7	stard9	stard9	ADJ
m326m042z67	5	8	depleted	depleted	ADJ
m326m042z67	5	9	cells	cell	NOUN
m326m042z67	5	10	lack	lack	VERB
m326m042z67	5	11	lysosomal	lysosomal	NOUN
m326m042z67	5	12	tubulation	tubulation	NOUN
m326m042z67	5	13	and	and	CCONJ
m326m042z67	5	14	accumulate	accumulate	VERB
m326m042z67	5	15	cholesterol	cholesterol	NOUN
m326m042z67	5	16	.	.	PUNCT
m326m042z67	6	1	in	in	ADP
m326m042z67	6	2	addition	addition	NOUN
m326m042z67	6	3	,	,	PUNCT
m326m042z67	6	4	stard9	stard9	DET
m326m042z67	6	5	knockout	knockout	NOUN
m326m042z67	6	6	mice	mouse	NOUN
m326m042z67	6	7	develop	develop	VERB
m326m042z67	6	8	npc	npc	NOUN
m326m042z67	6	9	disease	disease	NOUN
m326m042z67	6	10	symptoms.interestingly	symptoms.interestingly	ADV
m326m042z67	6	11	,	,	PUNCT
m326m042z67	6	12	stard9	stard9	NOUN
m326m042z67	6	13	appears	appear	VERB
m326m042z67	6	14	to	to	PART
m326m042z67	6	15	be	be	AUX
m326m042z67	6	16	regulated	regulate	VERB
m326m042z67	6	17	by	by	ADP
m326m042z67	6	18	a	a	DET
m326m042z67	6	19	proposed	propose	VERB
m326m042z67	6	20	cholesterol	cholesterol	NOUN
m326m042z67	6	21	-	-	PUNCT
m326m042z67	6	22	binding	bind	VERB
m326m042z67	6	23	start	start	NOUN
m326m042z67	6	24	domain	domain	NOUN
m326m042z67	6	25	at	at	ADP
m326m042z67	6	26	the	the	DET
m326m042z67	6	27	c	c	NOUN
m326m042z67	6	28	-	-	PUNCT
m326m042z67	6	29	terminus	terminus	NOUN
m326m042z67	6	30	.	.	PUNCT
m326m042z67	7	1	removal	removal	NOUN
m326m042z67	7	2	of	of	ADP
m326m042z67	7	3	this	this	DET
m326m042z67	7	4	domain	domain	NOUN
m326m042z67	7	5	results	result	VERB
m326m042z67	7	6	in	in	ADP
m326m042z67	7	7	the	the	DET
m326m042z67	7	8	loss	loss	NOUN
m326m042z67	7	9	of	of	ADP
m326m042z67	7	10	lysosomal	lysosomal	NOUN
m326m042z67	7	11	tubulation	tubulation	NOUN
m326m042z67	7	12	,	,	PUNCT
m326m042z67	7	13	thereby	thereby	ADV
m326m042z67	7	14	causing	cause	VERB
m326m042z67	7	15	a	a	DET
m326m042z67	7	16	pathological	pathological	ADJ
m326m042z67	7	17	accumulation	accumulation	NOUN
m326m042z67	7	18	of	of	ADP
m326m042z67	7	19	cholesterol	cholesterol	NOUN
m326m042z67	7	20	within	within	ADP
m326m042z67	7	21	the	the	DET
m326m042z67	7	22	lysosome	lysosome	NOUN
m326m042z67	7	23	.	.	PUNCT
m326m042z67	8	1	a	a	DET
m326m042z67	8	2	novel	novel	ADJ
m326m042z67	8	3	lysosomal	lysosomal	NOUN
m326m042z67	8	4	tubulation	tubulation	PROPN
m326m042z67	8	5	assay	assay	PROPN
m326m042z67	8	6	was	be	AUX
m326m042z67	8	7	generated	generate	VERB
m326m042z67	8	8	to	to	PART
m326m042z67	8	9	test	test	VERB
m326m042z67	8	10	stard9	stard9	ADJ
m326m042z67	8	11	sterol	sterol	NOUN
m326m042z67	8	12	-	-	PUNCT
m326m042z67	8	13	sensing	sensing	NOUN
m326m042z67	8	14	in	in	ADP
m326m042z67	8	15	relation	relation	NOUN
m326m042z67	8	16	to	to	ADP
m326m042z67	8	17	lysosomal	lysosomal	NOUN
m326m042z67	8	18	tubulation	tubulation	NOUN
m326m042z67	8	19	.	.	PUNCT
m326m042z67	9	1	cells	cell	NOUN
m326m042z67	9	2	were	be	AUX
m326m042z67	9	3	starved	starve	VERB
m326m042z67	9	4	of	of	ADP
m326m042z67	9	5	cholesterol	cholesterol	NOUN
m326m042z67	9	6	and	and	CCONJ
m326m042z67	9	7	subjected	subject	VERB
m326m042z67	9	8	to	to	AUX
m326m042z67	9	9	live	live	VERB
m326m042z67	9	10	cell	cell	NOUN
m326m042z67	9	11	imaging	imaging	NOUN
m326m042z67	9	12	.	.	PUNCT
m326m042z67	10	1	tubulation	tubulation	NOUN
m326m042z67	10	2	is	be	AUX
m326m042z67	10	3	significantly	significantly	ADV
m326m042z67	10	4	impaired	impair	VERB
m326m042z67	10	5	in	in	ADP
m326m042z67	10	6	cholesterol	cholesterol	NOUN
m326m042z67	10	7	-	-	PUNCT
m326m042z67	10	8	free	free	ADJ
m326m042z67	10	9	conditions	condition	NOUN
m326m042z67	10	10	and	and	CCONJ
m326m042z67	10	11	is	be	AUX
m326m042z67	10	12	rescued	rescue	VERB
m326m042z67	10	13	by	by	ADP
m326m042z67	10	14	ldl	ldl	NOUN
m326m042z67	10	15	treatment	treatment	NOUN
m326m042z67	10	16	.	.	PUNCT
m326m042z67	11	1	this	this	PRON
m326m042z67	11	2	does	do	AUX
m326m042z67	11	3	not	not	PART
m326m042z67	11	4	occur	occur	VERB
m326m042z67	11	5	without	without	ADP
m326m042z67	11	6	stard9	stard9	ADJ
m326m042z67	11	7	sterol	sterol	NOUN
m326m042z67	11	8	-	-	PUNCT
m326m042z67	11	9	binding	bind	VERB
m326m042z67	11	10	.	.	PUNCT
m326m042z67	12	1	together	together	ADV
m326m042z67	12	2	,	,	PUNCT
m326m042z67	12	3	these	these	DET
m326m042z67	12	4	results	result	NOUN
m326m042z67	12	5	suggest	suggest	VERB
m326m042z67	12	6	that	that	SCONJ
m326m042z67	12	7	cholesterol	cholesterol	NOUN
m326m042z67	12	8	acts	act	VERB
m326m042z67	12	9	a	a	DET
m326m042z67	12	10	novel	novel	NOUN
m326m042z67	12	11	signaling	signal	VERB
m326m042z67	12	12	molecule	molecule	NOUN
m326m042z67	12	13	by	by	ADP
m326m042z67	12	14	binding	bind	VERB
m326m042z67	12	15	to	to	ADP
m326m042z67	12	16	the	the	DET
m326m042z67	12	17	start	start	NOUN
m326m042z67	12	18	domain	domain	NOUN
m326m042z67	12	19	of	of	ADP
m326m042z67	12	20	stard9	stard9	NOUN
m326m042z67	12	21	to	to	PART
m326m042z67	12	22	stimulate	stimulate	VERB
m326m042z67	12	23	lysosomal	lysosomal	NOUN
m326m042z67	12	24	tubulation.oxysterols	tubulation.oxysterol	NOUN
m326m042z67	12	25	are	be	AUX
m326m042z67	12	26	natural	natural	ADJ
m326m042z67	12	27	cholesterol	cholesterol	NOUN
m326m042z67	12	28	analogues	analogue	NOUN
m326m042z67	12	29	that	that	PRON
m326m042z67	12	30	are	be	AUX
m326m042z67	12	31	known	know	VERB
m326m042z67	12	32	to	to	PART
m326m042z67	12	33	modulate	modulate	VERB
m326m042z67	12	34	cholesterol	cholesterol	NOUN
m326m042z67	12	35	metabolism	metabolism	NOUN
m326m042z67	12	36	.	.	PUNCT
m326m042z67	13	1	interestingly	interestingly	ADV
m326m042z67	13	2	,	,	PUNCT
m326m042z67	13	3	treatment	treatment	NOUN
m326m042z67	13	4	with	with	ADP
m326m042z67	13	5	purified	purify	VERB
m326m042z67	13	6	oxysterols	oxysterol	NOUN
m326m042z67	13	7	also	also	ADV
m326m042z67	13	8	rescues	rescue	VERB
m326m042z67	13	9	lysosomal	lysosomal	NOUN
m326m042z67	13	10	tubulation	tubulation	NOUN
m326m042z67	13	11	.	.	PUNCT
m326m042z67	14	1	one	one	NUM
m326m042z67	14	2	oxysterol	oxysterol	NOUN
m326m042z67	14	3	,	,	PUNCT
m326m042z67	14	4	oxysterol	oxysterol	NOUN
m326m042z67	14	5	-	-	PUNCT
m326m042z67	14	6	x	x	PROPN
m326m042z67	14	7	,	,	PUNCT
m326m042z67	14	8	was	be	AUX
m326m042z67	14	9	able	able	ADJ
m326m042z67	14	10	to	to	PART
m326m042z67	14	11	rescue	rescue	VERB
m326m042z67	14	12	lysosomal	lysosomal	NOUN
m326m042z67	14	13	tubulation	tubulation	NOUN
m326m042z67	14	14	to	to	ADP
m326m042z67	14	15	control	control	NOUN
m326m042z67	14	16	levels	level	NOUN
m326m042z67	14	17	.	.	PUNCT
m326m042z67	15	1	oxysterol	oxysterol	NOUN
m326m042z67	15	2	-	-	PUNCT
m326m042z67	15	3	x	x	NOUN
m326m042z67	15	4	treatment	treatment	NOUN
m326m042z67	15	5	,	,	PUNCT
m326m042z67	15	6	through	through	ADP
m326m042z67	15	7	activation	activation	NOUN
m326m042z67	15	8	of	of	ADP
m326m042z67	15	9	lysosomal	lysosomal	NOUN
m326m042z67	15	10	tubulation	tubulation	NOUN
m326m042z67	15	11	,	,	PUNCT
m326m042z67	15	12	ameliorated	ameliorate	VERB
m326m042z67	15	13	cholesterol	cholesterol	NOUN
m326m042z67	15	14	accumulation	accumulation	NOUN
m326m042z67	15	15	in	in	ADP
m326m042z67	15	16	both	both	CCONJ
m326m042z67	15	17	in	in	ADP
m326m042z67	15	18	vitro	vitro	X
m326m042z67	15	19	and	and	CCONJ
m326m042z67	15	20	in	in	ADP
m326m042z67	15	21	vivo	vivo	ADJ
m326m042z67	15	22	models	model	NOUN
m326m042z67	15	23	of	of	ADP
m326m042z67	15	24	npc	npc	PROPN
m326m042z67	15	25	disease.taken	disease.taken	PROPN
m326m042z67	15	26	together	together	ADV
m326m042z67	15	27	,	,	PUNCT
m326m042z67	15	28	these	these	DET
m326m042z67	15	29	studies	study	NOUN
m326m042z67	15	30	demonstrate	demonstrate	VERB
m326m042z67	15	31	that	that	SCONJ
m326m042z67	15	32	stard9	stard9	NOUN
m326m042z67	15	33	is	be	AUX
m326m042z67	15	34	a	a	DET
m326m042z67	15	35	multifunctional	multifunctional	ADJ
m326m042z67	15	36	kinesin	kinesin	NOUN
m326m042z67	15	37	that	that	PRON
m326m042z67	15	38	couples	couple	VERB
m326m042z67	15	39	ldl	ldl	NOUN
m326m042z67	15	40	-	-	PUNCT
m326m042z67	15	41	uptake	uptake	NOUN
m326m042z67	15	42	to	to	ADP
m326m042z67	15	43	the	the	DET
m326m042z67	15	44	projection	projection	NOUN
m326m042z67	15	45	of	of	ADP
m326m042z67	15	46	lysosomal	lysosomal	NOUN
m326m042z67	15	47	membrane	membrane	NOUN
m326m042z67	15	48	tubules	tubule	NOUN
m326m042z67	15	49	,	,	PUNCT
m326m042z67	15	50	thereby	thereby	ADV
m326m042z67	15	51	serving	serve	VERB
m326m042z67	15	52	as	as	ADP
m326m042z67	15	53	a	a	DET
m326m042z67	15	54	compelling	compelling	ADJ
m326m042z67	15	55	therapeutic	therapeutic	ADJ
m326m042z67	15	56	target	target	NOUN
m326m042z67	15	57	for	for	ADP
m326m042z67	15	58	treating	treat	VERB
m326m042z67	15	59	npc	npc	NOUN
m326m042z67	15	60	disease	disease	NOUN
m326m042z67	15	61	.	.	PUNCT