id sid tid token lemma pos m326m042z2v 1 1 the the DET m326m042z2v 1 2 development development NOUN m326m042z2v 1 3 of of ADP m326m042z2v 1 4 the the DET m326m042z2v 1 5 high high ADJ m326m042z2v 1 6 - - PUNCT m326m042z2v 1 7 throughput throughput NOUN m326m042z2v 1 8 rna rna NOUN m326m042z2v 1 9 - - PUNCT m326m042z2v 1 10 sequencing sequence VERB m326m042z2v 1 11 ( ( PUNCT m326m042z2v 1 12 rna rna PROPN m326m042z2v 1 13 - - PUNCT m326m042z2v 1 14 seq seq PROPN m326m042z2v 1 15 ) ) PUNCT m326m042z2v 1 16 technique technique NOUN m326m042z2v 1 17 at at ADP m326m042z2v 1 18 the the DET m326m042z2v 1 19 single single ADJ m326m042z2v 1 20 - - PUNCT m326m042z2v 1 21 cell cell NOUN m326m042z2v 1 22 level level NOUN m326m042z2v 1 23 enables enable VERB m326m042z2v 1 24 the the DET m326m042z2v 1 25 measurement measurement NOUN m326m042z2v 1 26 of of ADP m326m042z2v 1 27 gene gene NOUN m326m042z2v 1 28 expression expression NOUN m326m042z2v 1 29 in in ADP m326m042z2v 1 30 a a DET m326m042z2v 1 31 large large ADJ m326m042z2v 1 32 number number NOUN m326m042z2v 1 33 of of ADP m326m042z2v 1 34 individual individual ADJ m326m042z2v 1 35 cells cell NOUN m326m042z2v 1 36 simultaneously simultaneously ADV m326m042z2v 1 37 . . PUNCT m326m042z2v 2 1 computational computational ADJ m326m042z2v 2 2 methods method NOUN m326m042z2v 2 3 previously previously ADV m326m042z2v 2 4 developed develop VERB m326m042z2v 2 5 for for ADP m326m042z2v 2 6 the the DET m326m042z2v 2 7 regular regular ADJ m326m042z2v 2 8 ( ( PUNCT m326m042z2v 2 9 bulk bulk NOUN m326m042z2v 2 10 - - PUNCT m326m042z2v 2 11 based base VERB m326m042z2v 2 12 ) ) PUNCT m326m042z2v 2 13 rna rna PROPN m326m042z2v 2 14 - - PUNCT m326m042z2v 2 15 seq seq PROPN m326m042z2v 2 16 data datum NOUN m326m042z2v 2 17 analysis analysis NOUN m326m042z2v 2 18 often often ADV m326m042z2v 2 19 have have VERB m326m042z2v 2 20 insufficient insufficient ADJ m326m042z2v 2 21 power power NOUN m326m042z2v 2 22 on on ADP m326m042z2v 2 23 single single ADJ m326m042z2v 2 24 - - PUNCT m326m042z2v 2 25 cell cell NOUN m326m042z2v 2 26 data datum NOUN m326m042z2v 2 27 , , PUNCT m326m042z2v 2 28 due due ADP m326m042z2v 2 29 to to ADP m326m042z2v 2 30 the the DET m326m042z2v 2 31 high high ADJ m326m042z2v 2 32 sparsity sparsity NOUN m326m042z2v 2 33 nature nature NOUN m326m042z2v 2 34 and and CCONJ m326m042z2v 2 35 the the DET m326m042z2v 2 36 large large ADJ m326m042z2v 2 37 variance variance NOUN m326m042z2v 2 38 of of ADP m326m042z2v 2 39 single single ADJ m326m042z2v 2 40 - - PUNCT m326m042z2v 2 41 cell cell NOUN m326m042z2v 2 42 data datum NOUN m326m042z2v 2 43 . . PUNCT m326m042z2v 3 1 in in ADP m326m042z2v 3 2 this this DET m326m042z2v 3 3 dissertation dissertation NOUN m326m042z2v 3 4 , , PUNCT m326m042z2v 3 5 we we PRON m326m042z2v 3 6 present present VERB m326m042z2v 3 7 three three NUM m326m042z2v 3 8 methods method NOUN m326m042z2v 3 9 focusing focus VERB m326m042z2v 3 10 on on ADP m326m042z2v 3 11 two two NUM m326m042z2v 3 12 central central ADJ m326m042z2v 3 13 problems problem NOUN m326m042z2v 3 14 of of ADP m326m042z2v 3 15 single single ADJ m326m042z2v 3 16 - - PUNCT m326m042z2v 3 17 cell cell NOUN m326m042z2v 3 18 rna rna PROPN m326m042z2v 3 19 - - PUNCT m326m042z2v 3 20 seq seq PROPN m326m042z2v 3 21 ( ( PUNCT m326m042z2v 3 22 scrna scrna PROPN m326m042z2v 3 23 - - PUNCT m326m042z2v 3 24 seq seq PROPN m326m042z2v 3 25 ) ) PUNCT m326m042z2v 3 26 data datum NOUN m326m042z2v 3 27 analysis analysis NOUN m326m042z2v 3 28 : : PUNCT m326m042z2v 3 29 classification classification NOUN m326m042z2v 3 30 of of ADP m326m042z2v 3 31 samples sample NOUN m326m042z2v 3 32 and and CCONJ m326m042z2v 3 33 differential differential ADJ m326m042z2v 3 34 expression expression NOUN m326m042z2v 3 35 ( ( PUNCT m326m042z2v 3 36 de de X m326m042z2v 3 37 ) ) PUNCT m326m042z2v 3 38 analysis analysis NOUN m326m042z2v 3 39 of of ADP m326m042z2v 3 40 genes.the genes.the DET m326m042z2v 3 41 first first ADJ m326m042z2v 3 42 method method NOUN m326m042z2v 3 43 is be AUX m326m042z2v 3 44 a a DET m326m042z2v 3 45 ` ` PUNCT m326m042z2v 3 46 ` ` PUNCT m326m042z2v 3 47 scale scale NOUN m326m042z2v 3 48 - - PUNCT m326m042z2v 3 49 invariant invariant ADJ m326m042z2v 3 50 '' '' PUNCT m326m042z2v 3 51 classifier classifier NOUN m326m042z2v 3 52 used use VERB m326m042z2v 3 53 to to PART m326m042z2v 3 54 classify classify VERB m326m042z2v 3 55 cells cell NOUN m326m042z2v 3 56 / / SYM m326m042z2v 3 57 samples sample NOUN m326m042z2v 3 58 into into ADP m326m042z2v 3 59 different different ADJ m326m042z2v 3 60 groups group NOUN m326m042z2v 3 61 based base VERB m326m042z2v 3 62 on on ADP m326m042z2v 3 63 their their PRON m326m042z2v 3 64 gene gene NOUN m326m042z2v 3 65 expression expression NOUN m326m042z2v 3 66 . . PUNCT m326m042z2v 4 1 scaling scale VERB m326m042z2v 4 2 by by ADP m326m042z2v 4 3 sequencing sequence VERB m326m042z2v 4 4 depth depth NOUN m326m042z2v 4 5 is be AUX m326m042z2v 4 6 usually usually ADV m326m042z2v 4 7 the the DET m326m042z2v 4 8 first first ADJ m326m042z2v 4 9 step step NOUN m326m042z2v 4 10 for for ADP m326m042z2v 4 11 any any DET m326m042z2v 4 12 analysis analysis NOUN m326m042z2v 4 13 of of ADP m326m042z2v 4 14 rna rna PROPN m326m042z2v 4 15 - - PUNCT m326m042z2v 4 16 seq seq PROPN m326m042z2v 4 17 data datum NOUN m326m042z2v 4 18 , , PUNCT m326m042z2v 4 19 but but CCONJ m326m042z2v 4 20 estimating estimate VERB m326m042z2v 4 21 sequencing sequence VERB m326m042z2v 4 22 depth depth NOUN m326m042z2v 4 23 accurately accurately ADV m326m042z2v 4 24 can can AUX m326m042z2v 4 25 be be AUX m326m042z2v 4 26 difficult difficult ADJ m326m042z2v 4 27 , , PUNCT m326m042z2v 4 28 especially especially ADV m326m042z2v 4 29 for for ADP m326m042z2v 4 30 single single ADJ m326m042z2v 4 31 - - PUNCT m326m042z2v 4 32 cell cell NOUN m326m042z2v 4 33 data datum NOUN m326m042z2v 4 34 , , PUNCT m326m042z2v 4 35 which which PRON m326m042z2v 4 36 may may AUX m326m042z2v 4 37 influence influence VERB m326m042z2v 4 38 the the DET m326m042z2v 4 39 validity validity NOUN m326m042z2v 4 40 of of ADP m326m042z2v 4 41 downstream downstream ADJ m326m042z2v 4 42 analysis analysis NOUN m326m042z2v 4 43 . . PUNCT m326m042z2v 5 1 we we PRON m326m042z2v 5 2 eliminate eliminate VERB m326m042z2v 5 3 the the DET m326m042z2v 5 4 need need NOUN m326m042z2v 5 5 of of ADP m326m042z2v 5 6 scaling scale VERB m326m042z2v 5 7 completely completely ADV m326m042z2v 5 8 and and CCONJ m326m042z2v 5 9 enable enable ADJ m326m042z2v 5 10 analyzing analyze VERB m326m042z2v 5 11 using use VERB m326m042z2v 5 12 the the DET m326m042z2v 5 13 original original ADJ m326m042z2v 5 14 count count NOUN m326m042z2v 5 15 data datum NOUN m326m042z2v 5 16 directly directly ADV m326m042z2v 5 17 by by ADP m326m042z2v 5 18 developing develop VERB m326m042z2v 5 19 a a DET m326m042z2v 5 20 scale scale ADJ m326m042z2v 5 21 - - PUNCT m326m042z2v 5 22 invariant invariant ADJ m326m042z2v 5 23 classifier classifier NOUN m326m042z2v 5 24 , , PUNCT m326m042z2v 5 25 which which PRON m326m042z2v 5 26 gives give VERB m326m042z2v 5 27 the the DET m326m042z2v 5 28 same same ADJ m326m042z2v 5 29 result result NOUN m326m042z2v 5 30 under under ADP m326m042z2v 5 31 different different ADJ m326m042z2v 5 32 ( ( PUNCT m326m042z2v 5 33 arbitrary arbitrary ADJ m326m042z2v 5 34 ) ) PUNCT m326m042z2v 5 35 estimates estimate NOUN m326m042z2v 5 36 of of ADP m326m042z2v 5 37 sequencing sequence VERB m326m042z2v 5 38 depth depth NOUN m326m042z2v 5 39 . . PUNCT m326m042z2v 6 1 meanwhile meanwhile ADV m326m042z2v 6 2 , , PUNCT m326m042z2v 6 3 this this DET m326m042z2v 6 4 deep deep ADJ m326m042z2v 6 5 - - PUNCT m326m042z2v 6 6 neural neural ADJ m326m042z2v 6 7 - - PUNCT m326m042z2v 6 8 network network NOUN m326m042z2v 6 9 - - PUNCT m326m042z2v 6 10 based base VERB m326m042z2v 6 11 classifier classifier NOUN m326m042z2v 6 12 is be AUX m326m042z2v 6 13 able able ADJ m326m042z2v 6 14 to to PART m326m042z2v 6 15 achieve achieve VERB m326m042z2v 6 16 higher high ADJ m326m042z2v 6 17 classification classification NOUN m326m042z2v 6 18 accuracy accuracy NOUN m326m042z2v 6 19 compared compare VERB m326m042z2v 6 20 to to ADP m326m042z2v 6 21 previous previous ADJ m326m042z2v 6 22 classifiers classifier NOUN m326m042z2v 6 23 that that PRON m326m042z2v 6 24 require require VERB m326m042z2v 6 25 scaling.the scaling.the DET m326m042z2v 6 26 second second ADJ m326m042z2v 6 27 method method NOUN m326m042z2v 6 28 is be AUX m326m042z2v 6 29 proposed propose VERB m326m042z2v 6 30 for for ADP m326m042z2v 6 31 de de X m326m042z2v 6 32 analysis analysis NOUN m326m042z2v 6 33 of of ADP m326m042z2v 6 34 scrna scrna PROPN m326m042z2v 6 35 - - PUNCT m326m042z2v 6 36 seq seq PROPN m326m042z2v 6 37 data datum NOUN m326m042z2v 6 38 . . PUNCT m326m042z2v 7 1 de de X m326m042z2v 7 2 analysis analysis NOUN m326m042z2v 7 3 identifies identify VERB m326m042z2v 7 4 genes gene NOUN m326m042z2v 7 5 of of ADP m326m042z2v 7 6 which which PRON m326m042z2v 7 7 the the DET m326m042z2v 7 8 expression expression NOUN m326m042z2v 7 9 level level NOUN m326m042z2v 7 10 is be AUX m326m042z2v 7 11 different different ADJ m326m042z2v 7 12 from from ADP m326m042z2v 7 13 biological biological ADJ m326m042z2v 7 14 groups group NOUN m326m042z2v 7 15 to to ADP m326m042z2v 7 16 biological biological ADJ m326m042z2v 7 17 groups group NOUN m326m042z2v 7 18 . . PUNCT m326m042z2v 8 1 most most ADJ m326m042z2v 8 2 of of ADP m326m042z2v 8 3 existing exist VERB m326m042z2v 8 4 approaches approach NOUN m326m042z2v 8 5 detect detect VERB m326m042z2v 8 6 the the DET m326m042z2v 8 7 mean mean ADJ m326m042z2v 8 8 difference difference NOUN m326m042z2v 8 9 in in ADP m326m042z2v 8 10 expression expression NOUN m326m042z2v 8 11 levels level NOUN m326m042z2v 8 12 in in ADP m326m042z2v 8 13 different different ADJ m326m042z2v 8 14 groups group NOUN m326m042z2v 8 15 , , PUNCT m326m042z2v 8 16 our our PRON m326m042z2v 8 17 approach approach NOUN m326m042z2v 8 18 , , PUNCT m326m042z2v 8 19 named name VERB m326m042z2v 8 20 fastde fastde PROPN m326m042z2v 8 21 , , PUNCT m326m042z2v 8 22 instead instead ADV m326m042z2v 8 23 detects detect VERB m326m042z2v 8 24 changes change NOUN m326m042z2v 8 25 in in ADP m326m042z2v 8 26 distributions distribution NOUN m326m042z2v 8 27 . . PUNCT m326m042z2v 9 1 further far ADV m326m042z2v 9 2 , , PUNCT m326m042z2v 9 3 fastde fastde PROPN m326m042z2v 9 4 is be AUX m326m042z2v 9 5 capable capable ADJ m326m042z2v 9 6 of of ADP m326m042z2v 9 7 handling handle VERB m326m042z2v 9 8 data datum NOUN m326m042z2v 9 9 from from ADP m326m042z2v 9 10 multiple multiple ADJ m326m042z2v 9 11 nominal nominal ADJ m326m042z2v 9 12 or or CCONJ m326m042z2v 9 13 ordinal ordinal ADJ m326m042z2v 9 14 biological biological ADJ m326m042z2v 9 15 conditions condition NOUN m326m042z2v 9 16 , , PUNCT m326m042z2v 9 17 and and CCONJ m326m042z2v 9 18 it it PRON m326m042z2v 9 19 provides provide VERB m326m042z2v 9 20 an an DET m326m042z2v 9 21 intuitive intuitive ADJ m326m042z2v 9 22 visualization visualization NOUN m326m042z2v 9 23 to to PART m326m042z2v 9 24 facilitate facilitate VERB m326m042z2v 9 25 the the DET m326m042z2v 9 26 interpretation interpretation NOUN m326m042z2v 9 27 of of ADP m326m042z2v 9 28 de de X m326m042z2v 9 29 results.the results.the DET m326m042z2v 9 30 third third ADJ m326m042z2v 9 31 method method NOUN m326m042z2v 9 32 we we PRON m326m042z2v 9 33 present present VERB m326m042z2v 9 34 is be AUX m326m042z2v 9 35 for for ADP m326m042z2v 9 36 post post ADJ m326m042z2v 9 37 - - ADJ m326m042z2v 9 38 clustering clustering ADJ m326m042z2v 9 39 de de X m326m042z2v 9 40 analysis analysis NOUN m326m042z2v 9 41 of of ADP m326m042z2v 9 42 scrna scrna PROPN m326m042z2v 9 43 - - PUNCT m326m042z2v 9 44 seq seq PROPN m326m042z2v 9 45 data datum NOUN m326m042z2v 9 46 . . PUNCT m326m042z2v 10 1 different different ADJ m326m042z2v 10 2 from from ADP m326m042z2v 10 3 de de X m326m042z2v 10 4 analysis analysis NOUN m326m042z2v 10 5 of of ADP m326m042z2v 10 6 the the DET m326m042z2v 10 7 bulk bulk ADV m326m042z2v 10 8 - - PUNCT m326m042z2v 10 9 based base VERB m326m042z2v 10 10 rna rna PROPN m326m042z2v 10 11 - - PUNCT m326m042z2v 10 12 seq seq PROPN m326m042z2v 10 13 data datum NOUN m326m042z2v 10 14 , , PUNCT m326m042z2v 10 15 where where SCONJ m326m042z2v 10 16 the the DET m326m042z2v 10 17 grouping grouping NOUN m326m042z2v 10 18 of of ADP m326m042z2v 10 19 samples sample NOUN m326m042z2v 10 20 is be AUX m326m042z2v 10 21 known know VERB m326m042z2v 10 22 beforehand beforehand ADV m326m042z2v 10 23 , , PUNCT m326m042z2v 10 24 the the DET m326m042z2v 10 25 grouping grouping NOUN m326m042z2v 10 26 of of ADP m326m042z2v 10 27 samples sample NOUN m326m042z2v 10 28 ( ( PUNCT m326m042z2v 10 29 i.e. i.e. X m326m042z2v 10 30 , , PUNCT m326m042z2v 10 31 cells cell NOUN m326m042z2v 10 32 ) ) PUNCT m326m042z2v 10 33 is be AUX m326m042z2v 10 34 computationally computationally ADV m326m042z2v 10 35 inferred infer VERB m326m042z2v 10 36 using use VERB m326m042z2v 10 37 a a DET m326m042z2v 10 38 clustering clustering NOUN m326m042z2v 10 39 algorithm algorithm NOUN m326m042z2v 10 40 on on ADP m326m042z2v 10 41 the the DET m326m042z2v 10 42 same same ADJ m326m042z2v 10 43 data datum NOUN m326m042z2v 10 44 . . PUNCT m326m042z2v 11 1 this this DET m326m042z2v 11 2 " " PUNCT m326m042z2v 11 3 double double ADJ m326m042z2v 11 4 - - PUNCT m326m042z2v 11 5 use use NOUN m326m042z2v 11 6 " " PUNCT m326m042z2v 11 7 of of ADP m326m042z2v 11 8 data datum NOUN m326m042z2v 11 9 brings bring VERB m326m042z2v 11 10 a a DET m326m042z2v 11 11 data datum NOUN m326m042z2v 11 12 snooping snooping NOUN m326m042z2v 11 13 problem problem NOUN m326m042z2v 11 14 , , PUNCT m326m042z2v 11 15 bringing bring VERB m326m042z2v 11 16 a a DET m326m042z2v 11 17 high high ADJ m326m042z2v 11 18 risk risk NOUN m326m042z2v 11 19 of of ADP m326m042z2v 11 20 overwhelming overwhelm VERB m326m042z2v 11 21 false false ADJ m326m042z2v 11 22 positives positive NOUN m326m042z2v 11 23 . . PUNCT m326m042z2v 12 1 to to PART m326m042z2v 12 2 lower lower VERB m326m042z2v 12 3 this this DET m326m042z2v 12 4 risk risk NOUN m326m042z2v 12 5 , , PUNCT m326m042z2v 12 6 we we PRON m326m042z2v 12 7 propose propose VERB m326m042z2v 12 8 a a DET m326m042z2v 12 9 post post ADJ m326m042z2v 12 10 - - ADJ m326m042z2v 12 11 clustering clustering ADJ m326m042z2v 12 12 de de X m326m042z2v 12 13 test test NOUN m326m042z2v 12 14 called call VERB m326m042z2v 12 15 " " PUNCT m326m042z2v 12 16 depoc depoc NOUN m326m042z2v 12 17 " " PUNCT m326m042z2v 12 18 , , PUNCT m326m042z2v 12 19 which which PRON m326m042z2v 12 20 takes take VERB m326m042z2v 12 21 into into ADP m326m042z2v 12 22 account account NOUN m326m042z2v 12 23 the the DET m326m042z2v 12 24 uncertainty uncertainty NOUN m326m042z2v 12 25 of of ADP m326m042z2v 12 26 clustering clustering NOUN m326m042z2v 12 27 . . PUNCT m326m042z2v 13 1 depoc depoc NOUN m326m042z2v 13 2 is be AUX m326m042z2v 13 3 implemented implement VERB m326m042z2v 13 4 as as ADP m326m042z2v 13 5 a a DET m326m042z2v 13 6 modification modification NOUN m326m042z2v 13 7 of of ADP m326m042z2v 13 8 the the DET m326m042z2v 13 9 popular popular ADJ m326m042z2v 13 10 edger edger NOUN m326m042z2v 13 11 software software NOUN m326m042z2v 13 12 for for ADP m326m042z2v 13 13 de de X m326m042z2v 13 14 analysis analysis NOUN m326m042z2v 13 15 , , PUNCT m326m042z2v 13 16 which which PRON m326m042z2v 13 17 maximizes maximize VERB m326m042z2v 13 18 its its PRON m326m042z2v 13 19 ease ease NOUN m326m042z2v 13 20 of of ADP m326m042z2v 13 21 use use NOUN m326m042z2v 13 22 . . PUNCT m326m042z2v 14 1 we we PRON m326m042z2v 14 2 study study VERB m326m042z2v 14 3 the the DET m326m042z2v 14 4 theoretical theoretical ADJ m326m042z2v 14 5 properties property NOUN m326m042z2v 14 6 of of ADP m326m042z2v 14 7 depoc depoc NOUN m326m042z2v 14 8 and and CCONJ m326m042z2v 14 9 show show VERB m326m042z2v 14 10 that that SCONJ m326m042z2v 14 11 depoc depoc NOUN m326m042z2v 14 12 typically typically ADV m326m042z2v 14 13 gives give VERB m326m042z2v 14 14 more more ADV m326m042z2v 14 15 conservative conservative ADJ m326m042z2v 14 16 p p NOUN m326m042z2v 14 17 - - PUNCT m326m042z2v 14 18 values value NOUN m326m042z2v 14 19 than than ADP m326m042z2v 14 20 edger edger NOUN m326m042z2v 14 21 . . PUNCT