id	sid	tid	token	lemma	pos
m039k359906	1	1	for	for	ADP
m039k359906	1	2	a	a	DET
m039k359906	1	3	patient	patient	NOUN
m039k359906	1	4	with	with	ADP
m039k359906	1	5	metastatic	metastatic	ADJ
m039k359906	1	6	colorectal	colorectal	ADJ
m039k359906	1	7	cancer	cancer	NOUN
m039k359906	1	8	,	,	PUNCT
m039k359906	1	9	there	there	PRON
m039k359906	1	10	are	be	VERB
m039k359906	1	11	limited	limited	ADJ
m039k359906	1	12	clinical	clinical	ADJ
m039k359906	1	13	options	option	NOUN
m039k359906	1	14	aside	aside	ADV
m039k359906	1	15	from	from	ADP
m039k359906	1	16	chemotherapy	chemotherapy	NOUN
m039k359906	1	17	.	.	PUNCT
m039k359906	2	1	unfortunately	unfortunately	ADV
m039k359906	2	2	,	,	PUNCT
m039k359906	2	3	the	the	DET
m039k359906	2	4	development	development	NOUN
m039k359906	2	5	of	of	ADP
m039k359906	2	6	new	new	ADJ
m039k359906	2	7	chemotherapies	chemotherapy	NOUN
m039k359906	2	8	is	be	AUX
m039k359906	2	9	a	a	DET
m039k359906	2	10	long	long	ADJ
m039k359906	2	11	and	and	CCONJ
m039k359906	2	12	costly	costly	ADJ
m039k359906	2	13	process	process	NOUN
m039k359906	2	14	.	.	PUNCT
m039k359906	3	1	aside	aside	ADV
m039k359906	3	2	from	from	ADP
m039k359906	3	3	ethical	ethical	ADJ
m039k359906	3	4	concerns	concern	NOUN
m039k359906	3	5	,	,	PUNCT
m039k359906	3	6	typical	typical	ADJ
m039k359906	3	7	in	in	ADP
m039k359906	3	8	vivo	vivo	ADJ
m039k359906	3	9	research	research	NOUN
m039k359906	3	10	on	on	ADP
m039k359906	3	11	these	these	DET
m039k359906	3	12	toxic	toxic	ADJ
m039k359906	3	13	chemotherapeutic	chemotherapeutic	ADJ
m039k359906	3	14	drugs	drug	NOUN
m039k359906	3	15	is	be	AUX
m039k359906	3	16	low	low	ADJ
m039k359906	3	17	throughput	throughput	NOUN
m039k359906	3	18	,	,	PUNCT
m039k359906	3	19	time	time	NOUN
m039k359906	3	20	consuming	consume	VERB
m039k359906	3	21	and	and	CCONJ
m039k359906	3	22	costly	costly	ADJ
m039k359906	3	23	.	.	PUNCT
m039k359906	4	1	in	in	ADP
m039k359906	4	2	this	this	DET
m039k359906	4	3	project	project	NOUN
m039k359906	4	4	,	,	PUNCT
m039k359906	4	5	two	two	NUM
m039k359906	4	6	novel	novel	NOUN
m039k359906	4	7	in	in	ADP
m039k359906	4	8	vitro	vitro	X
m039k359906	4	9	platforms	platform	NOUN
m039k359906	4	10	are	be	AUX
m039k359906	4	11	employed	employ	VERB
m039k359906	4	12	to	to	PART
m039k359906	4	13	better	well	ADV
m039k359906	4	14	understand	understand	VERB
m039k359906	4	15	the	the	DET
m039k359906	4	16	effects	effect	NOUN
m039k359906	4	17	of	of	ADP
m039k359906	4	18	chemotherapeutic	chemotherapeutic	ADJ
m039k359906	4	19	treatments	treatment	NOUN
m039k359906	4	20	on	on	ADP
m039k359906	4	21	colon	colon	NOUN
m039k359906	4	22	cancer	cancer	NOUN
m039k359906	4	23	cells	cell	NOUN
m039k359906	4	24	:	:	PUNCT
m039k359906	4	25	tumor	tumor	NOUN
m039k359906	4	26	spheroids	spheroid	NOUN
m039k359906	4	27	and	and	CCONJ
m039k359906	4	28	paper	paper	NOUN
m039k359906	4	29	-	-	PUNCT
m039k359906	4	30	based	base	VERB
m039k359906	4	31	cultures	culture	NOUN
m039k359906	4	32	.	.	PUNCT
m039k359906	5	1	the	the	DET
m039k359906	5	2	first	first	ADJ
m039k359906	5	3	part	part	NOUN
m039k359906	5	4	of	of	ADP
m039k359906	5	5	this	this	DET
m039k359906	5	6	thesis	thesis	NOUN
m039k359906	5	7	utilizes	utilize	VERB
m039k359906	5	8	3	3	NUM
m039k359906	5	9	-	-	PUNCT
m039k359906	5	10	dimensional	dimensional	ADJ
m039k359906	5	11	cell	cell	NOUN
m039k359906	5	12	culture	culture	NOUN
m039k359906	5	13	tumor	tumor	NOUN
m039k359906	5	14	spheroids	spheroid	NOUN
m039k359906	5	15	.	.	PUNCT
m039k359906	6	1	these	these	DET
m039k359906	6	2	multi	multi	ADJ
m039k359906	6	3	-	-	ADJ
m039k359906	6	4	cellular	cellular	ADJ
m039k359906	6	5	aggregates	aggregate	NOUN
m039k359906	6	6	,	,	PUNCT
m039k359906	6	7	or	or	CCONJ
m039k359906	6	8	spheroids	spheroid	NOUN
m039k359906	6	9	,	,	PUNCT
m039k359906	6	10	of	of	ADP
m039k359906	6	11	colorectal	colorectal	ADJ
m039k359906	6	12	cancer	cancer	NOUN
m039k359906	6	13	cells	cell	NOUN
m039k359906	6	14	have	have	AUX
m039k359906	6	15	been	be	AUX
m039k359906	6	16	shown	show	VERB
m039k359906	6	17	to	to	PART
m039k359906	6	18	exhibit	exhibit	VERB
m039k359906	6	19	many	many	ADJ
m039k359906	6	20	of	of	ADP
m039k359906	6	21	the	the	DET
m039k359906	6	22	physiological	physiological	ADJ
m039k359906	6	23	and	and	CCONJ
m039k359906	6	24	chemical	chemical	NOUN
m039k359906	6	25	gradients	gradient	NOUN
m039k359906	6	26	of	of	ADP
m039k359906	6	27	a	a	DET
m039k359906	6	28	typical	typical	ADJ
m039k359906	6	29	clinical	clinical	ADJ
m039k359906	6	30	tumor	tumor	NOUN
m039k359906	6	31	,	,	PUNCT
m039k359906	6	32	while	while	SCONJ
m039k359906	6	33	still	still	ADV
m039k359906	6	34	maintaining	maintain	VERB
m039k359906	6	35	the	the	DET
m039k359906	6	36	flexibility	flexibility	NOUN
m039k359906	6	37	of	of	ADP
m039k359906	6	38	a	a	DET
m039k359906	6	39	cell	cell	NOUN
m039k359906	6	40	culture	culture	NOUN
m039k359906	6	41	system	system	NOUN
m039k359906	6	42	.	.	PUNCT
m039k359906	7	1	this	this	DET
m039k359906	7	2	project	project	NOUN
m039k359906	7	3	utilizes	utilize	VERB
m039k359906	7	4	a	a	DET
m039k359906	7	5	3d	3d	NOUN
m039k359906	7	6	printed	print	VERB
m039k359906	7	7	fluidic	fluidic	ADJ
m039k359906	7	8	device	device	NOUN
m039k359906	7	9	that	that	PRON
m039k359906	7	10	facilitates	facilitate	VERB
m039k359906	7	11	high	high	ADJ
m039k359906	7	12	-	-	PUNCT
m039k359906	7	13	throughput	throughput	NOUN
m039k359906	7	14	treatment	treatment	NOUN
m039k359906	7	15	of	of	ADP
m039k359906	7	16	these	these	DET
m039k359906	7	17	tumor	tumor	NOUN
m039k359906	7	18	spheroids	spheroid	NOUN
m039k359906	7	19	across	across	ADP
m039k359906	7	20	a	a	DET
m039k359906	7	21	semipermeable	semipermeable	NOUN
m039k359906	7	22	membrane	membrane	NOUN
m039k359906	7	23	.	.	PUNCT
m039k359906	8	1	the	the	DET
m039k359906	8	2	device	device	NOUN
m039k359906	8	3	also	also	ADV
m039k359906	8	4	allows	allow	VERB
m039k359906	8	5	for	for	ADP
m039k359906	8	6	a	a	DET
m039k359906	8	7	dynamic	dynamic	ADJ
m039k359906	8	8	drug	drug	NOUN
m039k359906	8	9	-	-	PUNCT
m039k359906	8	10	dosing	dosing	NOUN
m039k359906	8	11	gradient	gradient	NOUN
m039k359906	8	12	similar	similar	ADJ
m039k359906	8	13	to	to	ADP
m039k359906	8	14	a	a	DET
m039k359906	8	15	typical	typical	ADJ
m039k359906	8	16	in	in	ADP
m039k359906	8	17	vivo	vivo	ADJ
m039k359906	8	18	pharmacokinetic	pharmacokinetic	ADJ
m039k359906	8	19	profile	profile	NOUN
m039k359906	8	20	.	.	PUNCT
m039k359906	9	1	the	the	DET
m039k359906	9	2	treated	treat	VERB
m039k359906	9	3	tumor	tumor	NOUN
m039k359906	9	4	spheroids	spheroid	NOUN
m039k359906	9	5	are	be	AUX
m039k359906	9	6	evaluated	evaluate	VERB
m039k359906	9	7	with	with	ADP
m039k359906	9	8	maldi	maldi	PROPN
m039k359906	9	9	-	-	PUNCT
m039k359906	9	10	imaging	image	VERB
m039k359906	9	11	mass	mass	NOUN
m039k359906	9	12	spectrometry	spectrometry	NOUN
m039k359906	9	13	to	to	PART
m039k359906	9	14	elucidate	elucidate	VERB
m039k359906	9	15	the	the	DET
m039k359906	9	16	spatial	spatial	ADJ
m039k359906	9	17	distribution	distribution	NOUN
m039k359906	9	18	of	of	ADP
m039k359906	9	19	the	the	DET
m039k359906	9	20	drug	drug	NOUN
m039k359906	9	21	molecules	molecule	NOUN
m039k359906	9	22	and	and	CCONJ
m039k359906	9	23	corresponding	correspond	VERB
m039k359906	9	24	metabolites	metabolite	NOUN
m039k359906	9	25	.	.	PUNCT
m039k359906	10	1	spheroids	spheroid	NOUN
m039k359906	10	2	are	be	AUX
m039k359906	10	3	also	also	ADV
m039k359906	10	4	analyzed	analyze	VERB
m039k359906	10	5	for	for	ADP
m039k359906	10	6	the	the	DET
m039k359906	10	7	quantitative	quantitative	ADJ
m039k359906	10	8	proteomic	proteomic	ADJ
m039k359906	10	9	changes	change	NOUN
m039k359906	10	10	induced	induce	VERB
m039k359906	10	11	by	by	ADP
m039k359906	10	12	treatment	treatment	NOUN
m039k359906	10	13	.	.	PUNCT
m039k359906	11	1	this	this	DET
m039k359906	11	2	innovative	innovative	ADJ
m039k359906	11	3	system	system	NOUN
m039k359906	11	4	enables	enable	VERB
m039k359906	11	5	both	both	CCONJ
m039k359906	11	6	pharmacokinetic	pharmacokinetic	ADJ
m039k359906	11	7	and	and	CCONJ
m039k359906	11	8	pharmacodynamic	pharmacodynamic	ADJ
m039k359906	11	9	evaluations	evaluation	NOUN
m039k359906	11	10	for	for	ADP
m039k359906	11	11	a	a	DET
m039k359906	11	12	wide	wide	ADJ
m039k359906	11	13	range	range	NOUN
m039k359906	11	14	of	of	ADP
m039k359906	11	15	compounds	compound	NOUN
m039k359906	11	16	,	,	PUNCT
m039k359906	11	17	and	and	CCONJ
m039k359906	11	18	can	can	AUX
m039k359906	11	19	have	have	VERB
m039k359906	11	20	a	a	DET
m039k359906	11	21	transformative	transformative	ADJ
m039k359906	11	22	impact	impact	NOUN
m039k359906	11	23	on	on	ADP
m039k359906	11	24	the	the	DET
m039k359906	11	25	pre	pre	ADJ
m039k359906	11	26	-	-	ADJ
m039k359906	11	27	clinical	clinical	ADJ
m039k359906	11	28	evaluation	evaluation	NOUN
m039k359906	11	29	of	of	ADP
m039k359906	11	30	drug	drug	NOUN
m039k359906	11	31	candidates	candidate	NOUN
m039k359906	11	32	.	.	PUNCT
m039k359906	12	1	the	the	DET
m039k359906	12	2	second	second	ADJ
m039k359906	12	3	part	part	NOUN
m039k359906	12	4	of	of	ADP
m039k359906	12	5	this	this	DET
m039k359906	12	6	thesis	thesis	NOUN
m039k359906	12	7	focuses	focus	VERB
m039k359906	12	8	on	on	ADP
m039k359906	12	9	another	another	DET
m039k359906	12	10	a	a	DET
m039k359906	12	11	novel	novel	NOUN
m039k359906	12	12	in	in	ADP
m039k359906	12	13	vitro	vitro	X
m039k359906	12	14	platform	platform	NOUN
m039k359906	12	15	,	,	PUNCT
m039k359906	12	16	paperbased	paperbase	VERB
m039k359906	12	17	cultures	culture	NOUN
m039k359906	12	18	(	(	PUNCT
m039k359906	12	19	pbcs	pbcs	PROPN
m039k359906	12	20	)	)	PUNCT
m039k359906	12	21	.	.	PUNCT
m039k359906	13	1	individual	individual	ADJ
m039k359906	13	2	layers	layer	NOUN
m039k359906	13	3	of	of	ADP
m039k359906	13	4	paper	paper	NOUN
m039k359906	13	5	are	be	AUX
m039k359906	13	6	seeded	seed	VERB
m039k359906	13	7	with	with	ADP
m039k359906	13	8	colon	colon	NOUN
m039k359906	13	9	cancer	cancer	NOUN
m039k359906	13	10	cells	cell	NOUN
m039k359906	13	11	,	,	PUNCT
m039k359906	13	12	stacked	stack	VERB
m039k359906	13	13	together	together	ADV
m039k359906	13	14	into	into	ADP
m039k359906	13	15	a	a	DET
m039k359906	13	16	3d	3d	NOUN
m039k359906	13	17	structure	structure	NOUN
m039k359906	13	18	containing	contain	VERB
m039k359906	13	19	a	a	DET
m039k359906	13	20	diffusion	diffusion	NOUN
m039k359906	13	21	-	-	PUNCT
m039k359906	13	22	limited	limit	VERB
m039k359906	13	23	environment	environment	NOUN
m039k359906	13	24	generated	generate	VERB
m039k359906	13	25	with	with	ADP
m039k359906	13	26	the	the	DET
m039k359906	13	27	use	use	NOUN
m039k359906	13	28	of	of	ADP
m039k359906	13	29	diffusion	diffusion	NOUN
m039k359906	13	30	limiting	limit	VERB
m039k359906	13	31	membranes	membrane	NOUN
m039k359906	13	32	and	and	CCONJ
m039k359906	13	33	stainless	stainless	ADJ
m039k359906	13	34	steel	steel	NOUN
m039k359906	13	35	holders	holder	NOUN
m039k359906	13	36	.	.	PUNCT
m039k359906	14	1	these	these	DET
m039k359906	14	2	pbcs	pbcs	NOUN
m039k359906	14	3	display	display	VERB
m039k359906	14	4	monotonic	monotonic	ADJ
m039k359906	14	5	gradients	gradient	NOUN
m039k359906	14	6	similar	similar	ADJ
m039k359906	14	7	to	to	ADP
m039k359906	14	8	the	the	DET
m039k359906	14	9	gradients	gradient	NOUN
m039k359906	14	10	found	find	VERB
m039k359906	14	11	in	in	ADP
m039k359906	14	12	poorly	poorly	ADV
m039k359906	14	13	vascularized	vascularized	ADJ
m039k359906	14	14	tumors	tumor	NOUN
m039k359906	14	15	,	,	PUNCT
m039k359906	14	16	making	make	VERB
m039k359906	14	17	paper	paper	NOUN
m039k359906	14	18	-	-	PUNCT
m039k359906	14	19	based	base	VERB
m039k359906	14	20	cultures	culture	NOUN
m039k359906	14	21	a	a	DET
m039k359906	14	22	3d	3d	NOUN
m039k359906	14	23	tumor	tumor	NOUN
m039k359906	14	24	mimic	mimic	PROPN
m039k359906	14	25	.	.	PUNCT
m039k359906	15	1	individual	individual	ADJ
m039k359906	15	2	layers	layer	NOUN
m039k359906	15	3	of	of	ADP
m039k359906	15	4	pbcs	pbc	NOUN
m039k359906	15	5	were	be	AUX
m039k359906	15	6	characterized	characterize	VERB
m039k359906	15	7	for	for	ADP
m039k359906	15	8	cell	cell	NOUN
m039k359906	15	9	viability	viability	NOUN
m039k359906	15	10	,	,	PUNCT
m039k359906	15	11	proliferation	proliferation	NOUN
m039k359906	15	12	and	and	CCONJ
m039k359906	15	13	drug	drug	NOUN
m039k359906	15	14	response	response	NOUN
m039k359906	15	15	.	.	PUNCT
m039k359906	16	1	pbcs	pbc	NOUN
m039k359906	16	2	were	be	AUX
m039k359906	16	3	dosed	dose	VERB
m039k359906	16	4	with	with	ADP
m039k359906	16	5	chemotherapeutics	chemotherapeutic	NOUN
m039k359906	16	6	and	and	CCONJ
m039k359906	16	7	monitored	monitor	VERB
m039k359906	16	8	for	for	ADP
m039k359906	16	9	the	the	DET
m039k359906	16	10	cellular	cellular	ADJ
m039k359906	16	11	response	response	NOUN
m039k359906	16	12	at	at	ADP
m039k359906	16	13	different	different	ADJ
m039k359906	16	14	regions	region	NOUN
m039k359906	16	15	within	within	ADP
m039k359906	16	16	the	the	DET
m039k359906	16	17	pbcs	pbcs	NOUN
m039k359906	16	18	.	.	PUNCT
m039k359906	17	1	we	we	PRON
m039k359906	17	2	also	also	ADV
m039k359906	17	3	developed	develop	VERB
m039k359906	17	4	a	a	DET
m039k359906	17	5	methodology	methodology	NOUN
m039k359906	17	6	to	to	PART
m039k359906	17	7	perform	perform	VERB
m039k359906	17	8	maldi	maldi	PROPN
m039k359906	17	9	-	-	PUNCT
m039k359906	17	10	imaging	image	VERB
m039k359906	17	11	mass	mass	NOUN
m039k359906	17	12	spectrometry	spectrometry	NOUN
m039k359906	17	13	on	on	ADP
m039k359906	17	14	pbcs	pbcs	PROPN
m039k359906	17	15	.	.	PUNCT
m039k359906	18	1	the	the	DET
m039k359906	18	2	described	describe	VERB
m039k359906	18	3	analytical	analytical	ADJ
m039k359906	18	4	platforms	platform	NOUN
m039k359906	18	5	enable	enable	VERB
m039k359906	18	6	preclinical	preclinical	ADJ
m039k359906	18	7	chemotherapeutic	chemotherapeutic	ADJ
m039k359906	18	8	analysis	analysis	NOUN
m039k359906	18	9	and	and	CCONJ
m039k359906	18	10	are	be	AUX
m039k359906	18	11	readily	readily	ADV
m039k359906	18	12	available	available	ADJ
m039k359906	18	13	for	for	ADP
m039k359906	18	14	the	the	DET
m039k359906	18	15	exploration	exploration	NOUN
m039k359906	18	16	of	of	ADP
m039k359906	18	17	new	new	ADJ
m039k359906	18	18	and	and	CCONJ
m039k359906	18	19	creative	creative	ADJ
m039k359906	18	20	cancer	cancer	NOUN
m039k359906	18	21	treatments	treatment	NOUN
m039k359906	18	22	.	.	PUNCT