id	sid	tid	token	lemma	pos
kw52j675b0b	1	1	bacterial	bacterial	ADJ
kw52j675b0b	1	2	antibiotic	antibiotic	ADJ
kw52j675b0b	1	3	resistance	resistance	NOUN
kw52j675b0b	1	4	mechanisms	mechanism	NOUN
kw52j675b0b	1	5	are	be	AUX
kw52j675b0b	1	6	an	an	DET
kw52j675b0b	1	7	emerging	emerge	VERB
kw52j675b0b	1	8	problem	problem	NOUN
kw52j675b0b	1	9	in	in	ADP
kw52j675b0b	1	10	the	the	DET
kw52j675b0b	1	11	treatment	treatment	NOUN
kw52j675b0b	1	12	of	of	ADP
kw52j675b0b	1	13	infectious	infectious	ADJ
kw52j675b0b	1	14	disease	disease	NOUN
kw52j675b0b	1	15	.	.	PUNCT
kw52j675b0b	2	1	the	the	DET
kw52j675b0b	2	2	overuse	overuse	NOUN
kw52j675b0b	2	3	of	of	ADP
kw52j675b0b	2	4	the	the	DET
kw52j675b0b	2	5	ì¢-lactam	ì¢-lactam	ADJ
kw52j675b0b	2	6	class	class	NOUN
kw52j675b0b	2	7	of	of	ADP
kw52j675b0b	2	8	antibiotics	antibiotic	NOUN
kw52j675b0b	2	9	within	within	ADP
kw52j675b0b	2	10	the	the	DET
kw52j675b0b	2	11	last	last	ADJ
kw52j675b0b	2	12	seventy	seventy	NUM
kw52j675b0b	2	13	years	year	NOUN
kw52j675b0b	2	14	has	have	AUX
kw52j675b0b	2	15	caused	cause	VERB
kw52j675b0b	2	16	a	a	DET
kw52j675b0b	2	17	rising	rise	VERB
kw52j675b0b	2	18	number	number	NOUN
kw52j675b0b	2	19	of	of	ADP
kw52j675b0b	2	20	cases	case	NOUN
kw52j675b0b	2	21	where	where	SCONJ
kw52j675b0b	2	22	the	the	DET
kw52j675b0b	2	23	most	most	ADV
kw52j675b0b	2	24	pathogenic	pathogenic	ADJ
kw52j675b0b	2	25	strain	strain	NOUN
kw52j675b0b	2	26	,	,	PUNCT
kw52j675b0b	2	27	methicillin	methicillin	PROPN
kw52j675b0b	2	28	resistant	resistant	ADJ
kw52j675b0b	2	29	staphylococcus	staphylococcus	PROPN
kw52j675b0b	2	30	aureus	aureus	PROPN
kw52j675b0b	2	31	(	(	PUNCT
kw52j675b0b	2	32	mrsa	mrsa	PROPN
kw52j675b0b	2	33	)	)	PUNCT
kw52j675b0b	2	34	,	,	PUNCT
kw52j675b0b	2	35	is	be	AUX
kw52j675b0b	2	36	in	in	ADP
kw52j675b0b	2	37	the	the	DET
kw52j675b0b	2	38	homes	home	NOUN
kw52j675b0b	2	39	and	and	CCONJ
kw52j675b0b	2	40	schools	school	NOUN
kw52j675b0b	2	41	of	of	ADP
kw52j675b0b	2	42	the	the	DET
kw52j675b0b	2	43	general	general	ADJ
kw52j675b0b	2	44	population	population	NOUN
kw52j675b0b	2	45	.	.	PUNCT
kw52j675b0b	3	1	to	to	PART
kw52j675b0b	3	2	defend	defend	VERB
kw52j675b0b	3	3	against	against	ADP
kw52j675b0b	3	4	the	the	DET
kw52j675b0b	3	5	potential	potential	ADJ
kw52j675b0b	3	6	disastrous	disastrous	ADJ
kw52j675b0b	3	7	consequences	consequence	NOUN
kw52j675b0b	3	8	efforts	effort	NOUN
kw52j675b0b	3	9	are	be	AUX
kw52j675b0b	3	10	needed	need	VERB
kw52j675b0b	3	11	to	to	PART
kw52j675b0b	3	12	understand	understand	VERB
kw52j675b0b	3	13	the	the	DET
kw52j675b0b	3	14	exact	exact	ADJ
kw52j675b0b	3	15	mechanism	mechanism	NOUN
kw52j675b0b	3	16	of	of	ADP
kw52j675b0b	3	17	drug	drug	NOUN
kw52j675b0b	3	18	resistance	resistance	NOUN
kw52j675b0b	3	19	in	in	ADP
kw52j675b0b	3	20	strains	strain	NOUN
kw52j675b0b	3	21	like	like	ADP
kw52j675b0b	3	22	mrsa	mrsa	PROPN
kw52j675b0b	3	23	and	and	CCONJ
kw52j675b0b	3	24	develop	develop	VERB
kw52j675b0b	3	25	novel	novel	ADJ
kw52j675b0b	3	26	treatment	treatment	NOUN
kw52j675b0b	3	27	strategies	strategy	NOUN
kw52j675b0b	3	28	.	.	PUNCT
kw52j675b0b	4	1	the	the	DET
kw52j675b0b	4	2	drug	drug	NOUN
kw52j675b0b	4	3	resistance	resistance	NOUN
kw52j675b0b	4	4	in	in	ADP
kw52j675b0b	4	5	mrsa	mrsa	PROPN
kw52j675b0b	4	6	strains	strain	NOUN
kw52j675b0b	4	7	is	be	AUX
kw52j675b0b	4	8	largely	largely	ADV
kw52j675b0b	4	9	due	due	ADJ
kw52j675b0b	4	10	to	to	ADP
kw52j675b0b	4	11	the	the	DET
kw52j675b0b	4	12	blar1	blar1	NOUN
kw52j675b0b	4	13	protein	protein	NOUN
kw52j675b0b	4	14	.	.	PUNCT
kw52j675b0b	5	1	blar1	blar1	NOUN
kw52j675b0b	5	2	is	be	AUX
kw52j675b0b	5	3	a	a	DET
kw52j675b0b	5	4	transmembrane	transmembrane	ADJ
kw52j675b0b	5	5	signaling	signal	VERB
kw52j675b0b	5	6	protein	protein	NOUN
kw52j675b0b	5	7	that	that	PRON
kw52j675b0b	5	8	initiates	initiate	VERB
kw52j675b0b	5	9	a	a	DET
kw52j675b0b	5	10	signal	signal	NOUN
kw52j675b0b	5	11	stimulus	stimulus	NOUN
kw52j675b0b	5	12	upon	upon	SCONJ
kw52j675b0b	5	13	binding	bind	VERB
kw52j675b0b	5	14	and	and	CCONJ
kw52j675b0b	5	15	recognition	recognition	NOUN
kw52j675b0b	5	16	of	of	ADP
kw52j675b0b	5	17	the	the	DET
kw52j675b0b	5	18	ì¢-lactam	ì¢-lactam	PROPN
kw52j675b0b	5	19	antibiotic	antibiotic	NOUN
kw52j675b0b	5	20	by	by	ADP
kw52j675b0b	5	21	the	the	DET
kw52j675b0b	5	22	extracellular	extracellular	ADJ
kw52j675b0b	5	23	sensor	sensor	NOUN
kw52j675b0b	5	24	domain	domain	NOUN
kw52j675b0b	5	25	.	.	PUNCT
kw52j675b0b	6	1	this	this	DET
kw52j675b0b	6	2	transmitted	transmit	VERB
kw52j675b0b	6	3	signal	signal	NOUN
kw52j675b0b	6	4	moves	move	NOUN
kw52j675b0b	6	5	across	across	ADP
kw52j675b0b	6	6	the	the	DET
kw52j675b0b	6	7	cell	cell	NOUN
kw52j675b0b	6	8	membrane	membrane	NOUN
kw52j675b0b	6	9	to	to	ADP
kw52j675b0b	6	10	the	the	DET
kw52j675b0b	6	11	intracellular	intracellular	ADJ
kw52j675b0b	6	12	domains	domain	NOUN
kw52j675b0b	6	13	.	.	PUNCT
kw52j675b0b	7	1	the	the	DET
kw52j675b0b	7	2	resulting	result	VERB
kw52j675b0b	7	3	response	response	NOUN
kw52j675b0b	7	4	is	be	AUX
kw52j675b0b	7	5	the	the	DET
kw52j675b0b	7	6	promotion	promotion	NOUN
kw52j675b0b	7	7	of	of	ADP
kw52j675b0b	7	8	blaz	blaz	ADJ
kw52j675b0b	7	9	expression	expression	NOUN
kw52j675b0b	7	10	,	,	PUNCT
kw52j675b0b	7	11	which	which	PRON
kw52j675b0b	7	12	is	be	AUX
kw52j675b0b	7	13	a	a	DET
kw52j675b0b	7	14	ì¢-lactamase	ì¢-lactamase	NOUN
kw52j675b0b	7	15	capable	capable	ADJ
kw52j675b0b	7	16	of	of	ADP
kw52j675b0b	7	17	neutralizing	neutralize	VERB
kw52j675b0b	7	18	the	the	DET
kw52j675b0b	7	19	available	available	ADJ
kw52j675b0b	7	20	ì¢-lactam	ì¢-lactam	ADJ
kw52j675b0b	7	21	antibiotic	antibiotic	NOUN
kw52j675b0b	7	22	.	.	PUNCT
kw52j675b0b	8	1	the	the	DET
kw52j675b0b	8	2	exact	exact	ADJ
kw52j675b0b	8	3	mechanism	mechanism	NOUN
kw52j675b0b	8	4	of	of	ADP
kw52j675b0b	8	5	signal	signal	ADJ
kw52j675b0b	8	6	initiation	initiation	NOUN
kw52j675b0b	8	7	and	and	CCONJ
kw52j675b0b	8	8	signal	signal	NOUN
kw52j675b0b	8	9	relay	relay	NOUN
kw52j675b0b	8	10	from	from	ADP
kw52j675b0b	8	11	the	the	DET
kw52j675b0b	8	12	extracellular	extracellular	NOUN
kw52j675b0b	8	13	to	to	ADP
kw52j675b0b	8	14	intracellular	intracellular	ADJ
kw52j675b0b	8	15	domains	domain	NOUN
kw52j675b0b	8	16	is	be	AUX
kw52j675b0b	8	17	currently	currently	ADV
kw52j675b0b	8	18	unknown	unknown	ADJ
kw52j675b0b	8	19	.	.	PUNCT
kw52j675b0b	9	1	the	the	DET
kw52j675b0b	9	2	work	work	NOUN
kw52j675b0b	9	3	of	of	ADP
kw52j675b0b	9	4	this	this	DET
kw52j675b0b	9	5	thesis	thesis	NOUN
kw52j675b0b	9	6	aims	aim	VERB
kw52j675b0b	9	7	to	to	PART
kw52j675b0b	9	8	understand	understand	VERB
kw52j675b0b	9	9	the	the	DET
kw52j675b0b	9	10	effects	effect	NOUN
kw52j675b0b	9	11	of	of	ADP
kw52j675b0b	9	12	antibiotic	antibiotic	ADJ
kw52j675b0b	9	13	addition	addition	NOUN
kw52j675b0b	9	14	on	on	ADP
kw52j675b0b	9	15	the	the	DET
kw52j675b0b	9	16	sensor	sensor	NOUN
kw52j675b0b	9	17	domain	domain	NOUN
kw52j675b0b	9	18	of	of	ADP
kw52j675b0b	9	19	blar1	blar1	X
kw52j675b0b	9	20	(	(	PUNCT
kw52j675b0b	9	21	blars	blar	NOUN
kw52j675b0b	9	22	)	)	PUNCT
kw52j675b0b	9	23	and	and	CCONJ
kw52j675b0b	9	24	the	the	DET
kw52j675b0b	9	25	modulated	modulate	VERB
kw52j675b0b	9	26	interaction	interaction	NOUN
kw52j675b0b	9	27	with	with	ADP
kw52j675b0b	9	28	the	the	DET
kw52j675b0b	9	29	other	other	ADJ
kw52j675b0b	9	30	extracellular	extracellular	ADJ
kw52j675b0b	9	31	domain	domain	NOUN
kw52j675b0b	9	32	(	(	PUNCT
kw52j675b0b	9	33	loop-2	loop-2	PROPN
kw52j675b0b	9	34	)	)	PUNCT
kw52j675b0b	9	35	.	.	PUNCT
kw52j675b0b	10	1	the	the	DET
kw52j675b0b	10	2	blars	blar	NOUN
kw52j675b0b	10	3	sensor	sensor	NOUN
kw52j675b0b	10	4	domain	domain	NOUN
kw52j675b0b	10	5	has	have	VERB
kw52j675b0b	10	6	high	high	ADJ
kw52j675b0b	10	7	structural	structural	ADJ
kw52j675b0b	10	8	conservation	conservation	NOUN
kw52j675b0b	10	9	with	with	ADP
kw52j675b0b	10	10	other	other	ADJ
kw52j675b0b	10	11	penicillin	penicillin	NOUN
kw52j675b0b	10	12	binding	bind	VERB
kw52j675b0b	10	13	proteins	protein	NOUN
kw52j675b0b	10	14	(	(	PUNCT
kw52j675b0b	10	15	pbps	pbps	X
kw52j675b0b	10	16	)	)	PUNCT
kw52j675b0b	10	17	and	and	CCONJ
kw52j675b0b	10	18	the	the	DET
kw52j675b0b	10	19	class	class	NOUN
kw52j675b0b	10	20	a	a	DET
kw52j675b0b	10	21	and	and	CCONJ
kw52j675b0b	10	22	d	d	NOUN
kw52j675b0b	10	23	ì¢-lactamases	ì¢-lactamase	NOUN
kw52j675b0b	10	24	,	,	PUNCT
kw52j675b0b	10	25	although	although	SCONJ
kw52j675b0b	10	26	the	the	DET
kw52j675b0b	10	27	proteins	protein	NOUN
kw52j675b0b	10	28	have	have	VERB
kw52j675b0b	10	29	low	low	ADJ
kw52j675b0b	10	30	sequence	sequence	NOUN
kw52j675b0b	10	31	homology	homology	NOUN
kw52j675b0b	10	32	.	.	PUNCT
kw52j675b0b	11	1	previous	previous	ADJ
kw52j675b0b	11	2	work	work	NOUN
kw52j675b0b	11	3	has	have	AUX
kw52j675b0b	11	4	initially	initially	ADV
kw52j675b0b	11	5	suggested	suggest	VERB
kw52j675b0b	11	6	that	that	SCONJ
kw52j675b0b	11	7	blars	blar	NOUN
kw52j675b0b	11	8	utilizes	utilize	VERB
kw52j675b0b	11	9	an	an	DET
kw52j675b0b	11	10	active	active	ADJ
kw52j675b0b	11	11	site	site	NOUN
kw52j675b0b	11	12	nì_-carboxylated	nì_-carboxylate	VERB
kw52j675b0b	11	13	lysine	lysine	NOUN
kw52j675b0b	11	14	(	(	PUNCT
kw52j675b0b	11	15	k392	k392	PROPN
kw52j675b0b	11	16	)	)	PUNCT
kw52j675b0b	11	17	and	and	CCONJ
kw52j675b0b	11	18	an	an	DET
kw52j675b0b	11	19	interaction	interaction	NOUN
kw52j675b0b	11	20	with	with	ADP
kw52j675b0b	11	21	the	the	DET
kw52j675b0b	11	22	extracellular	extracellular	ADJ
kw52j675b0b	11	23	loop-2	loop-2	PROPN
kw52j675b0b	11	24	domain	domain	NOUN
kw52j675b0b	11	25	within	within	ADP
kw52j675b0b	11	26	the	the	DET
kw52j675b0b	11	27	mechanism	mechanism	NOUN
kw52j675b0b	11	28	of	of	ADP
kw52j675b0b	11	29	signal	signal	ADJ
kw52j675b0b	11	30	transduction	transduction	NOUN
kw52j675b0b	11	31	.	.	PUNCT
kw52j675b0b	12	1	the	the	DET
kw52j675b0b	12	2	work	work	NOUN
kw52j675b0b	12	3	within	within	ADP
kw52j675b0b	12	4	this	this	DET
kw52j675b0b	12	5	thesis	thesis	NOUN
kw52j675b0b	12	6	uses	use	VERB
kw52j675b0b	12	7	nuclear	nuclear	ADJ
kw52j675b0b	12	8	magnetic	magnetic	ADJ
kw52j675b0b	12	9	resonance	resonance	NOUN
kw52j675b0b	12	10	(	(	PUNCT
kw52j675b0b	12	11	nmr	nmr	NOUN
kw52j675b0b	12	12	)	)	PUNCT
kw52j675b0b	12	13	as	as	ADP
kw52j675b0b	12	14	a	a	DET
kw52j675b0b	12	15	non	non	ADJ
kw52j675b0b	12	16	-	-	ADJ
kw52j675b0b	12	17	invasive	invasive	ADJ
kw52j675b0b	12	18	technique	technique	NOUN
kw52j675b0b	12	19	to	to	PART
kw52j675b0b	12	20	probe	probe	VERB
kw52j675b0b	12	21	the	the	DET
kw52j675b0b	12	22	formation	formation	NOUN
kw52j675b0b	12	23	of	of	ADP
kw52j675b0b	12	24	the	the	DET
kw52j675b0b	12	25	covalent	covalent	ADJ
kw52j675b0b	12	26	antibiotic	antibiotic	ADJ
kw52j675b0b	12	27	attachment	attachment	NOUN
kw52j675b0b	12	28	within	within	ADP
kw52j675b0b	12	29	blars	blar	NOUN
kw52j675b0b	12	30	and	and	CCONJ
kw52j675b0b	12	31	the	the	DET
kw52j675b0b	12	32	resulting	result	VERB
kw52j675b0b	12	33	effect	effect	NOUN
kw52j675b0b	12	34	to	to	ADP
kw52j675b0b	12	35	the	the	DET
kw52j675b0b	12	36	nì_-carboxylated	nì_-carboxylate	VERB
kw52j675b0b	12	37	k392	k392	PROPN
kw52j675b0b	12	38	side	side	NOUN
kw52j675b0b	12	39	chain	chain	NOUN
kw52j675b0b	12	40	and	and	CCONJ
kw52j675b0b	12	41	interaction	interaction	NOUN
kw52j675b0b	12	42	with	with	ADP
kw52j675b0b	12	43	the	the	DET
kw52j675b0b	12	44	loop-2	loop-2	PROPN
kw52j675b0b	12	45	domain	domain	NOUN
kw52j675b0b	12	46	peptide	peptide	NOUN
kw52j675b0b	12	47	mimic	mimic	VERB
kw52j675b0b	12	48	(	(	PUNCT
kw52j675b0b	12	49	l2short	l2short	NOUN
kw52j675b0b	12	50	)	)	PUNCT
kw52j675b0b	12	51	.	.	PUNCT
kw52j675b0b	13	1	this	this	DET
kw52j675b0b	13	2	work	work	NOUN
kw52j675b0b	13	3	acts	act	VERB
kw52j675b0b	13	4	to	to	PART
kw52j675b0b	13	5	fill	fill	VERB
kw52j675b0b	13	6	in	in	ADP
kw52j675b0b	13	7	gaps	gap	NOUN
kw52j675b0b	13	8	of	of	ADP
kw52j675b0b	13	9	the	the	DET
kw52j675b0b	13	10	previous	previous	ADJ
kw52j675b0b	13	11	research	research	NOUN
kw52j675b0b	13	12	and	and	CCONJ
kw52j675b0b	13	13	to	to	PART
kw52j675b0b	13	14	add	add	VERB
kw52j675b0b	13	15	a	a	DET
kw52j675b0b	13	16	new	new	ADJ
kw52j675b0b	13	17	understanding	understanding	NOUN
kw52j675b0b	13	18	of	of	ADP
kw52j675b0b	13	19	the	the	DET
kw52j675b0b	13	20	effects	effect	NOUN
kw52j675b0b	13	21	of	of	ADP
kw52j675b0b	13	22	antibiotic	antibiotic	ADJ
kw52j675b0b	13	23	binding	binding	NOUN
kw52j675b0b	13	24	using	use	VERB
kw52j675b0b	13	25	the	the	DET
kw52j675b0b	13	26	atomic	atomic	ADJ
kw52j675b0b	13	27	resolution	resolution	NOUN
kw52j675b0b	13	28	of	of	ADP
kw52j675b0b	13	29	nmr	nmr	PROPN
kw52j675b0b	13	30	.	.	PUNCT
kw52j675b0b	14	1	the	the	DET
kw52j675b0b	14	2	work	work	NOUN
kw52j675b0b	14	3	presented	present	VERB
kw52j675b0b	14	4	within	within	ADP
kw52j675b0b	14	5	this	this	DET
kw52j675b0b	14	6	thesis	thesis	NOUN
kw52j675b0b	14	7	observes	observe	VERB
kw52j675b0b	14	8	the	the	DET
kw52j675b0b	14	9	blars	blar	NOUN
kw52j675b0b	14	10	protein	protein	NOUN
kw52j675b0b	14	11	in	in	ADP
kw52j675b0b	14	12	its	its	PRON
kw52j675b0b	14	13	apo	apo	NOUN
kw52j675b0b	14	14	form	form	NOUN
kw52j675b0b	14	15	,	,	PUNCT
kw52j675b0b	14	16	complexed	complexe	VERB
kw52j675b0b	14	17	with	with	ADP
kw52j675b0b	14	18	l2short	l2short	NOUN
kw52j675b0b	14	19	,	,	PUNCT
kw52j675b0b	14	20	or	or	CCONJ
kw52j675b0b	14	21	acylated	acylate	VERB
kw52j675b0b	14	22	states	state	NOUN
kw52j675b0b	14	23	to	to	PART
kw52j675b0b	14	24	determine	determine	VERB
kw52j675b0b	14	25	the	the	DET
kw52j675b0b	14	26	mechanism	mechanism	NOUN
kw52j675b0b	14	27	of	of	ADP
kw52j675b0b	14	28	signal	signal	NOUN
kw52j675b0b	14	29	transduction	transduction	NOUN
kw52j675b0b	14	30	within	within	ADP
kw52j675b0b	14	31	the	the	DET
kw52j675b0b	14	32	protein	protein	NOUN
kw52j675b0b	14	33	.	.	PUNCT
kw52j675b0b	15	1	we	we	PRON
kw52j675b0b	15	2	observe	observe	VERB
kw52j675b0b	15	3	that	that	SCONJ
kw52j675b0b	15	4	the	the	DET
kw52j675b0b	15	5	nì_-carboxylated	nì_-carboxylate	VERB
kw52j675b0b	15	6	k392	k392	PROPN
kw52j675b0b	15	7	side	side	NOUN
kw52j675b0b	15	8	chain	chain	NOUN
kw52j675b0b	15	9	undergoes	undergo	VERB
kw52j675b0b	15	10	fast	fast	ADJ
kw52j675b0b	15	11	motions	motion	NOUN
kw52j675b0b	15	12	within	within	ADP
kw52j675b0b	15	13	the	the	DET
kw52j675b0b	15	14	active	active	ADJ
kw52j675b0b	15	15	site	site	NOUN
kw52j675b0b	15	16	,	,	PUNCT
kw52j675b0b	15	17	and	and	CCONJ
kw52j675b0b	15	18	simultaneously	simultaneously	ADV
kw52j675b0b	15	19	the	the	DET
kw52j675b0b	15	20	protein	protein	NOUN
kw52j675b0b	15	21	is	be	AUX
kw52j675b0b	15	22	found	find	VERB
kw52j675b0b	15	23	to	to	PART
kw52j675b0b	15	24	have	have	VERB
kw52j675b0b	15	25	slow	slow	ADJ
kw52j675b0b	15	26	timescale	timescale	NOUN
kw52j675b0b	15	27	(	(	PUNCT
kw52j675b0b	15	28	ìâs	ìâs	PROPN
kw52j675b0b	15	29	-	-	PUNCT
kw52j675b0b	15	30	ms	ms	PROPN
kw52j675b0b	15	31	)	)	PUNCT
kw52j675b0b	15	32	motions	motion	NOUN
kw52j675b0b	15	33	.	.	PUNCT
kw52j675b0b	16	1	upon	upon	SCONJ
kw52j675b0b	16	2	acylation	acylation	NOUN
kw52j675b0b	16	3	the	the	DET
kw52j675b0b	16	4	lysine	lysine	NOUN
kw52j675b0b	16	5	undergoes	undergo	VERB
kw52j675b0b	16	6	nì_-decarboxylation	nì_-decarboxylation	NOUN
kw52j675b0b	16	7	,	,	PUNCT
kw52j675b0b	16	8	allowing	allow	VERB
kw52j675b0b	16	9	the	the	DET
kw52j675b0b	16	10	ì¢-lactam	ì¢-lactam	NUM
kw52j675b0b	16	11	antibiotic	antibiotic	ADJ
kw52j675b0b	16	12	to	to	PART
kw52j675b0b	16	13	remain	remain	VERB
kw52j675b0b	16	14	bound	bound	ADJ
kw52j675b0b	16	15	.	.	PUNCT
kw52j675b0b	17	1	throughout	throughout	ADP
kw52j675b0b	17	2	the	the	DET
kw52j675b0b	17	3	transition	transition	NOUN
kw52j675b0b	17	4	from	from	ADP
kw52j675b0b	17	5	apo	apo	PROPN
kw52j675b0b	17	6	to	to	AUX
kw52j675b0b	17	7	acylated	acylate	VERB
kw52j675b0b	17	8	,	,	PUNCT
kw52j675b0b	17	9	blars	blar	VERB
kw52j675b0b	17	10	the	the	DET
kw52j675b0b	17	11	protein	protein	NOUN
kw52j675b0b	17	12	appears	appear	VERB
kw52j675b0b	17	13	to	to	PART
kw52j675b0b	17	14	rearrange	rearrange	VERB
kw52j675b0b	17	15	the	the	DET
kw52j675b0b	17	16	physical	physical	ADJ
kw52j675b0b	17	17	location	location	NOUN
kw52j675b0b	17	18	of	of	ADP
kw52j675b0b	17	19	slow	slow	ADJ
kw52j675b0b	17	20	motion	motion	NOUN
kw52j675b0b	17	21	dynamics	dynamic	NOUN
kw52j675b0b	17	22	.	.	PUNCT
kw52j675b0b	18	1	the	the	DET
kw52j675b0b	18	2	formation	formation	NOUN
kw52j675b0b	18	3	of	of	ADP
kw52j675b0b	18	4	a	a	DET
kw52j675b0b	18	5	hydrogen	hydrogen	NOUN
kw52j675b0b	18	6	bond	bond	NOUN
kw52j675b0b	18	7	network	network	NOUN
kw52j675b0b	18	8	to	to	ADP
kw52j675b0b	18	9	the	the	DET
kw52j675b0b	18	10	antibiotic	antibiotic	ADJ
kw52j675b0b	18	11	or	or	CCONJ
kw52j675b0b	18	12	the	the	DET
kw52j675b0b	18	13	lack	lack	NOUN
kw52j675b0b	18	14	of	of	ADP
kw52j675b0b	18	15	fast	fast	ADJ
kw52j675b0b	18	16	motions	motion	NOUN
kw52j675b0b	18	17	in	in	ADP
kw52j675b0b	18	18	the	the	DET
kw52j675b0b	18	19	decarboxylated	decarboxylated	ADJ
kw52j675b0b	18	20	lysine	lysine	NOUN
kw52j675b0b	18	21	side	side	NOUN
kw52j675b0b	18	22	chain	chain	NOUN
kw52j675b0b	18	23	may	may	AUX
kw52j675b0b	18	24	be	be	AUX
kw52j675b0b	18	25	the	the	DET
kw52j675b0b	18	26	cause	cause	NOUN
kw52j675b0b	18	27	of	of	ADP
kw52j675b0b	18	28	these	these	DET
kw52j675b0b	18	29	changes	change	NOUN
kw52j675b0b	18	30	.	.	PUNCT
kw52j675b0b	19	1	the	the	DET
kw52j675b0b	19	2	slow	slow	ADJ
kw52j675b0b	19	3	motions	motion	NOUN
kw52j675b0b	19	4	move	move	VERB
kw52j675b0b	19	5	within	within	ADP
kw52j675b0b	19	6	the	the	DET
kw52j675b0b	19	7	active	active	ADJ
kw52j675b0b	19	8	site	site	NOUN
kw52j675b0b	19	9	to	to	ADP
kw52j675b0b	19	10	a	a	DET
kw52j675b0b	19	11	region	region	NOUN
kw52j675b0b	19	12	of	of	ADP
kw52j675b0b	19	13	the	the	DET
kw52j675b0b	19	14	protein	protein	NOUN
kw52j675b0b	19	15	outside	outside	ADP
kw52j675b0b	19	16	of	of	ADP
kw52j675b0b	19	17	the	the	DET
kw52j675b0b	19	18	active	active	ADJ
kw52j675b0b	19	19	site	site	NOUN
kw52j675b0b	19	20	.	.	PUNCT
kw52j675b0b	20	1	this	this	DET
kw52j675b0b	20	2	dynamic	dynamic	ADJ
kw52j675b0b	20	3	rearrangement	rearrangement	NOUN
kw52j675b0b	20	4	is	be	AUX
kw52j675b0b	20	5	likely	likely	ADJ
kw52j675b0b	20	6	the	the	DET
kw52j675b0b	20	7	method	method	NOUN
kw52j675b0b	20	8	of	of	ADP
kw52j675b0b	20	9	signal	signal	ADJ
kw52j675b0b	20	10	initiation	initiation	NOUN
kw52j675b0b	20	11	in	in	ADP
kw52j675b0b	20	12	the	the	DET
kw52j675b0b	20	13	protein	protein	NOUN
kw52j675b0b	20	14	.	.	PUNCT
kw52j675b0b	21	1	the	the	DET
kw52j675b0b	21	2	synthesized	synthesized	ADJ
kw52j675b0b	21	3	peptide	peptide	NOUN
kw52j675b0b	21	4	representing	represent	VERB
kw52j675b0b	21	5	the	the	DET
kw52j675b0b	21	6	c	c	NOUN
kw52j675b0b	21	7	-	-	PUNCT
kw52j675b0b	21	8	terminus	terminus	NOUN
kw52j675b0b	21	9	of	of	ADP
kw52j675b0b	21	10	the	the	DET
kw52j675b0b	21	11	loop-2	loop-2	PROPN
kw52j675b0b	21	12	domain	domain	NOUN
kw52j675b0b	21	13	(	(	PUNCT
kw52j675b0b	21	14	l2short	l2short	NOUN
kw52j675b0b	21	15	)	)	PUNCT
kw52j675b0b	21	16	circumvented	circumvent	VERB
kw52j675b0b	21	17	solubility	solubility	NOUN
kw52j675b0b	21	18	issues	issue	NOUN
kw52j675b0b	21	19	found	find	VERB
kw52j675b0b	21	20	in	in	ADP
kw52j675b0b	21	21	the	the	DET
kw52j675b0b	21	22	full	full	ADJ
kw52j675b0b	21	23	-	-	PUNCT
kw52j675b0b	21	24	length	length	NOUN
kw52j675b0b	21	25	peptide	peptide	NOUN
kw52j675b0b	21	26	.	.	PUNCT
kw52j675b0b	22	1	the	the	DET
kw52j675b0b	22	2	l2short	l2short	NOUN
kw52j675b0b	22	3	peptide	peptide	NOUN
kw52j675b0b	22	4	contains	contain	VERB
kw52j675b0b	22	5	a	a	DET
kw52j675b0b	22	6	single	single	ADJ
kw52j675b0b	22	7	&	&	CCONJ
kw52j675b0b	22	8	gamma;-helix	gamma;-helix	ADJ
kw52j675b0b	22	9	,	,	PUNCT
kw52j675b0b	22	10	flanked	flank	VERB
kw52j675b0b	22	11	by	by	ADP
kw52j675b0b	22	12	two	two	NUM
kw52j675b0b	22	13	unstructured	unstructured	ADJ
kw52j675b0b	22	14	termini	termini	NOUN
kw52j675b0b	22	15	.	.	PUNCT
kw52j675b0b	23	1	the	the	DET
kw52j675b0b	23	2	comparison	comparison	NOUN
kw52j675b0b	23	3	of	of	ADP
kw52j675b0b	23	4	the	the	DET
kw52j675b0b	23	5	15n	15n	NOUN
kw52j675b0b	23	6	backbone	backbone	NOUN
kw52j675b0b	23	7	dynamics	dynamic	NOUN
kw52j675b0b	23	8	of	of	ADP
kw52j675b0b	23	9	the	the	DET
kw52j675b0b	23	10	l2short	l2short	NOUN
kw52j675b0b	23	11	peptide	peptide	NOUN
kw52j675b0b	23	12	,	,	PUNCT
kw52j675b0b	23	13	in	in	ADP
kw52j675b0b	23	14	the	the	DET
kw52j675b0b	23	15	presence	presence	NOUN
kw52j675b0b	23	16	and	and	CCONJ
kw52j675b0b	23	17	absence	absence	NOUN
kw52j675b0b	23	18	of	of	ADP
kw52j675b0b	23	19	the	the	DET
kw52j675b0b	23	20	blars	blar	NOUN
kw52j675b0b	23	21	,	,	PUNCT
kw52j675b0b	23	22	revealed	reveal	VERB
kw52j675b0b	23	23	the	the	DET
kw52j675b0b	23	24	blars	blar	NOUN
kw52j675b0b	23	25	binding	bind	VERB
kw52j675b0b	23	26	epitope	epitope	NOUN
kw52j675b0b	23	27	through	through	ADP
kw52j675b0b	23	28	the	the	DET
kw52j675b0b	23	29	increased	increase	VERB
kw52j675b0b	23	30	slow	slow	ADJ
kw52j675b0b	23	31	timescale	timescale	NOUN
kw52j675b0b	23	32	dynamics	dynamic	NOUN
kw52j675b0b	23	33	on	on	ADP
kw52j675b0b	23	34	the	the	DET
kw52j675b0b	23	35	peptide	peptide	NOUN
kw52j675b0b	23	36	.	.	PUNCT
kw52j675b0b	24	1	similarly	similarly	ADV
kw52j675b0b	24	2	,	,	PUNCT
kw52j675b0b	24	3	the	the	DET
kw52j675b0b	24	4	binding	bind	VERB
kw52j675b0b	24	5	epitope	epitope	NOUN
kw52j675b0b	24	6	on	on	ADP
kw52j675b0b	24	7	blars	blar	NOUN
kw52j675b0b	24	8	was	be	AUX
kw52j675b0b	24	9	identified	identify	VERB
kw52j675b0b	24	10	using	use	VERB
kw52j675b0b	24	11	chemical	chemical	NOUN
kw52j675b0b	24	12	shift	shift	NOUN
kw52j675b0b	24	13	perturbations	perturbation	NOUN
kw52j675b0b	24	14	(	(	PUNCT
kw52j675b0b	24	15	csps	csp	NOUN
kw52j675b0b	24	16	)	)	PUNCT
kw52j675b0b	24	17	along	along	ADP
kw52j675b0b	24	18	with	with	ADP
kw52j675b0b	24	19	the	the	DET
kw52j675b0b	24	20	saturation	saturation	NOUN
kw52j675b0b	24	21	transfer	transfer	NOUN
kw52j675b0b	24	22	difference	difference	NOUN
kw52j675b0b	24	23	(	(	PUNCT
kw52j675b0b	24	24	std	std	NOUN
kw52j675b0b	24	25	)	)	PUNCT
kw52j675b0b	24	26	experiment	experiment	NOUN
kw52j675b0b	24	27	.	.	PUNCT
kw52j675b0b	25	1	together	together	ADV
kw52j675b0b	25	2	this	this	DET
kw52j675b0b	25	3	information	information	NOUN
kw52j675b0b	25	4	served	serve	VERB
kw52j675b0b	25	5	as	as	ADP
kw52j675b0b	25	6	input	input	NOUN
kw52j675b0b	25	7	for	for	ADP
kw52j675b0b	25	8	the	the	DET
kw52j675b0b	25	9	haddock	haddock	NOUN
kw52j675b0b	25	10	software	software	NOUN
kw52j675b0b	25	11	in	in	ADP
kw52j675b0b	25	12	order	order	NOUN
kw52j675b0b	25	13	to	to	PART
kw52j675b0b	25	14	determine	determine	VERB
kw52j675b0b	25	15	the	the	DET
kw52j675b0b	25	16	likely	likely	ADJ
kw52j675b0b	25	17	site	site	NOUN
kw52j675b0b	25	18	of	of	ADP
kw52j675b0b	25	19	interaction	interaction	NOUN
kw52j675b0b	25	20	and	and	CCONJ
kw52j675b0b	25	21	orientation	orientation	NOUN
kw52j675b0b	25	22	of	of	ADP
kw52j675b0b	25	23	the	the	DET
kw52j675b0b	25	24	peptide	peptide	NOUN
kw52j675b0b	25	25	within	within	ADP
kw52j675b0b	25	26	the	the	DET
kw52j675b0b	25	27	binding	bind	VERB
kw52j675b0b	25	28	epitope	epitope	NOUN
kw52j675b0b	25	29	.	.	PUNCT
kw52j675b0b	26	1	finally	finally	ADV
kw52j675b0b	26	2	,	,	PUNCT
kw52j675b0b	26	3	the	the	DET
kw52j675b0b	26	4	addition	addition	NOUN
kw52j675b0b	26	5	of	of	ADP
kw52j675b0b	26	6	antibiotic	antibiotic	ADJ
kw52j675b0b	26	7	to	to	ADP
kw52j675b0b	26	8	the	the	DET
kw52j675b0b	26	9	blars	blar	NOUN
kw52j675b0b	26	10	/	/	SYM
kw52j675b0b	26	11	l2short	l2short	NOUN
kw52j675b0b	26	12	complex	complex	NOUN
kw52j675b0b	26	13	revealed	reveal	VERB
kw52j675b0b	26	14	,	,	PUNCT
kw52j675b0b	26	15	contrary	contrary	ADJ
kw52j675b0b	26	16	to	to	PART
kw52j675b0b	26	17	previously	previously	ADV
kw52j675b0b	26	18	published	publish	VERB
kw52j675b0b	26	19	work	work	NOUN
kw52j675b0b	26	20	,	,	PUNCT
kw52j675b0b	26	21	that	that	SCONJ
kw52j675b0b	26	22	the	the	DET
kw52j675b0b	26	23	interaction	interaction	NOUN
kw52j675b0b	26	24	with	with	ADP
kw52j675b0b	26	25	the	the	DET
kw52j675b0b	26	26	c	c	NOUN
kw52j675b0b	26	27	-	-	PUNCT
kw52j675b0b	26	28	terminus	terminus	NOUN
kw52j675b0b	26	29	of	of	ADP
kw52j675b0b	26	30	the	the	DET
kw52j675b0b	26	31	loop-2	loop-2	PROPN
kw52j675b0b	26	32	domain	domain	NOUN
kw52j675b0b	26	33	is	be	AUX
kw52j675b0b	26	34	unbroken	unbroken	VERB
kw52j675b0b	26	35	by	by	ADP
kw52j675b0b	26	36	acylation	acylation	NOUN
kw52j675b0b	26	37	of	of	ADP
kw52j675b0b	26	38	the	the	DET
kw52j675b0b	26	39	sensor	sensor	NOUN
kw52j675b0b	26	40	domain	domain	NOUN
kw52j675b0b	26	41	.	.	PUNCT
kw52j675b0b	27	1	this	this	PRON
kw52j675b0b	27	2	suggests	suggest	VERB
kw52j675b0b	27	3	a	a	DET
kw52j675b0b	27	4	deeper	deep	ADJ
kw52j675b0b	27	5	complexity	complexity	NOUN
kw52j675b0b	27	6	to	to	ADP
kw52j675b0b	27	7	the	the	DET
kw52j675b0b	27	8	role	role	NOUN
kw52j675b0b	27	9	of	of	ADP
kw52j675b0b	27	10	the	the	DET
kw52j675b0b	27	11	loop-2	loop-2	PROPN
kw52j675b0b	27	12	domain	domain	NOUN
kw52j675b0b	27	13	to	to	PART
kw52j675b0b	27	14	signal	signal	VERB
kw52j675b0b	27	15	transduction	transduction	NOUN
kw52j675b0b	27	16	within	within	ADP
kw52j675b0b	27	17	blar1	blar1	NOUN
kw52j675b0b	27	18	than	than	SCONJ
kw52j675b0b	27	19	previously	previously	ADV
kw52j675b0b	27	20	understood	understand	VERB
kw52j675b0b	27	21	.	.	PUNCT