id	sid	tid	token	lemma	pos
k3569310801	1	1	this	this	DET
k3569310801	1	2	dissertation	dissertation	NOUN
k3569310801	1	3	demonstrates	demonstrate	VERB
k3569310801	1	4	the	the	DET
k3569310801	1	5	application	application	NOUN
k3569310801	1	6	of	of	ADP
k3569310801	1	7	optimized	optimize	VERB
k3569310801	1	8	functional	functional	ADJ
k3569310801	1	9	nanomedicine	nanomedicine	NOUN
k3569310801	1	10	in	in	ADP
k3569310801	1	11	treating	treat	VERB
k3569310801	1	12	a	a	DET
k3569310801	1	13	variety	variety	NOUN
k3569310801	1	14	of	of	ADP
k3569310801	1	15	cancer	cancer	NOUN
k3569310801	1	16	at	at	ADP
k3569310801	1	17	preclinical	preclinical	ADJ
k3569310801	1	18	stage	stage	NOUN
k3569310801	1	19	.	.	PUNCT
k3569310801	2	1	our	our	PRON
k3569310801	2	2	studies	study	NOUN
k3569310801	2	3	focus	focus	VERB
k3569310801	2	4	on	on	ADP
k3569310801	2	5	peptide	peptide	NOUN
k3569310801	2	6	-	-	PUNCT
k3569310801	2	7	targeted	target	VERB
k3569310801	2	8	formulations	formulation	NOUN
k3569310801	2	9	by	by	ADP
k3569310801	2	10	going	go	VERB
k3569310801	2	11	after	after	ADP
k3569310801	2	12	extracellular	extracellular	ADJ
k3569310801	2	13	biomarkers	biomarker	NOUN
k3569310801	2	14	,	,	PUNCT
k3569310801	2	15	designing	design	VERB
k3569310801	2	16	and	and	CCONJ
k3569310801	2	17	optimizing	optimize	VERB
k3569310801	2	18	ligands	ligand	NOUN
k3569310801	2	19	accordingly	accordingly	ADV
k3569310801	2	20	by	by	ADP
k3569310801	2	21	tuning	tune	VERB
k3569310801	2	22	multivalency	multivalency	NOUN
k3569310801	2	23	and	and	CCONJ
k3569310801	2	24	avidity	avidity	NOUN
k3569310801	2	25	,	,	PUNCT
k3569310801	2	26	as	as	ADV
k3569310801	2	27	well	well	ADV
k3569310801	2	28	as	as	ADP
k3569310801	2	29	adjusting	adjust	VERB
k3569310801	2	30	selectivity	selectivity	ADJ
k3569310801	2	31	towards	towards	ADP
k3569310801	2	32	target	target	NOUN
k3569310801	2	33	cells	cell	NOUN
k3569310801	2	34	by	by	ADP
k3569310801	2	35	biophysical	biophysical	ADJ
k3569310801	2	36	and	and	CCONJ
k3569310801	2	37	chemical	chemical	NOUN
k3569310801	2	38	modifications	modification	NOUN
k3569310801	2	39	of	of	ADP
k3569310801	2	40	nanoparticles	nanoparticle	NOUN
k3569310801	2	41	.	.	PUNCT
k3569310801	3	1	chapter	chapter	NOUN
k3569310801	3	2	2	2	NUM
k3569310801	3	3	and	and	CCONJ
k3569310801	3	4	3	3	NUM
k3569310801	3	5	describes	describe	VERB
k3569310801	3	6	the	the	DET
k3569310801	3	7	significance	significance	NOUN
k3569310801	3	8	of	of	ADP
k3569310801	3	9	designing	design	VERB
k3569310801	3	10	rational	rational	ADJ
k3569310801	3	11	prodrugs	prodrug	NOUN
k3569310801	3	12	to	to	PART
k3569310801	3	13	achieve	achieve	VERB
k3569310801	3	14	controlled	control	VERB
k3569310801	3	15	and	and	CCONJ
k3569310801	3	16	selective	selective	ADJ
k3569310801	3	17	treatment	treatment	NOUN
k3569310801	3	18	in	in	ADP
k3569310801	3	19	multiple	multiple	ADJ
k3569310801	3	20	myeloma	myeloma	NOUN
k3569310801	3	21	and	and	CCONJ
k3569310801	3	22	lung	lung	NOUN
k3569310801	3	23	carcinoma	carcinoma	NOUN
k3569310801	3	24	,	,	PUNCT
k3569310801	3	25	respectively	respectively	ADV
k3569310801	3	26	.	.	PUNCT
k3569310801	4	1	importantly	importantly	ADV
k3569310801	4	2	,	,	PUNCT
k3569310801	4	3	the	the	DET
k3569310801	4	4	combined	combined	ADJ
k3569310801	4	5	strategy	strategy	NOUN
k3569310801	4	6	of	of	ADP
k3569310801	4	7	optimized	optimize	VERB
k3569310801	4	8	targeting	targeting	NOUN
k3569310801	4	9	ligand	ligand	NOUN
k3569310801	4	10	and	and	CCONJ
k3569310801	4	11	prodrugs	prodrug	NOUN
k3569310801	4	12	containing	contain	VERB
k3569310801	4	13	chemical	chemical	NOUN
k3569310801	4	14	linkers	linker	NOUN
k3569310801	4	15	susceptible	susceptible	ADJ
k3569310801	4	16	to	to	ADP
k3569310801	4	17	hydrolytic	hydrolytic	ADJ
k3569310801	4	18	enzymes	enzyme	NOUN
k3569310801	4	19	at	at	ADP
k3569310801	4	20	endosome	endosome	NOUN
k3569310801	4	21	of	of	ADP
k3569310801	4	22	cancer	cancer	NOUN
k3569310801	4	23	cells	cell	NOUN
k3569310801	4	24	,	,	PUNCT
k3569310801	4	25	has	have	AUX
k3569310801	4	26	proven	prove	VERB
k3569310801	4	27	to	to	PART
k3569310801	4	28	be	be	AUX
k3569310801	4	29	most	most	ADV
k3569310801	4	30	efficacious	efficacious	ADJ
k3569310801	4	31	for	for	ADP
k3569310801	4	32	inhibiting	inhibit	VERB
k3569310801	4	33	tumor	tumor	NOUN
k3569310801	4	34	progression	progression	NOUN
k3569310801	4	35	and	and	CCONJ
k3569310801	4	36	limiting	limit	VERB
k3569310801	4	37	toxicity	toxicity	NOUN
k3569310801	4	38	in	in	ADP
k3569310801	4	39	the	the	DET
k3569310801	4	40	studies	study	NOUN
k3569310801	4	41	described	describe	VERB
k3569310801	4	42	within	within	ADP
k3569310801	4	43	these	these	DET
k3569310801	4	44	chapters	chapter	NOUN
k3569310801	4	45	.	.	PUNCT
k3569310801	5	1	in	in	ADP
k3569310801	5	2	chapters	chapter	NOUN
k3569310801	5	3	4	4	NUM
k3569310801	5	4	through	through	ADP
k3569310801	5	5	6	6	NUM
k3569310801	5	6	,	,	PUNCT
k3569310801	5	7	a	a	DET
k3569310801	5	8	systematic	systematic	ADJ
k3569310801	5	9	approach	approach	NOUN
k3569310801	5	10	to	to	PART
k3569310801	5	11	achieve	achieve	VERB
k3569310801	5	12	endosomal	endosomal	ADJ
k3569310801	5	13	escape	escape	NOUN
k3569310801	5	14	and	and	CCONJ
k3569310801	5	15	target	target	NOUN
k3569310801	5	16	immune	immune	ADJ
k3569310801	5	17	cell	cell	NOUN
k3569310801	5	18	are	be	AUX
k3569310801	5	19	explored	explore	VERB
k3569310801	5	20	.	.	PUNCT
k3569310801	6	1	endosomal	endosomal	ADJ
k3569310801	6	2	escape	escape	NOUN
k3569310801	6	3	of	of	ADP
k3569310801	6	4	gene	gene	NOUN
k3569310801	6	5	-	-	PUNCT
k3569310801	6	6	modulating	modulate	VERB
k3569310801	6	7	proteins	protein	NOUN
k3569310801	6	8	has	have	AUX
k3569310801	6	9	been	be	AUX
k3569310801	6	10	a	a	DET
k3569310801	6	11	bottleneck	bottleneck	NOUN
k3569310801	6	12	in	in	ADP
k3569310801	6	13	the	the	DET
k3569310801	6	14	last	last	ADJ
k3569310801	6	15	three	three	NUM
k3569310801	6	16	decades	decade	NOUN
k3569310801	6	17	that	that	PRON
k3569310801	6	18	presents	present	VERB
k3569310801	6	19	substantial	substantial	ADJ
k3569310801	6	20	challenges	challenge	NOUN
k3569310801	6	21	in	in	ADP
k3569310801	6	22	achieving	achieve	VERB
k3569310801	6	23	therapeutic	therapeutic	ADJ
k3569310801	6	24	outcomes	outcome	NOUN
k3569310801	6	25	for	for	ADP
k3569310801	6	26	treating	treat	VERB
k3569310801	6	27	genetic	genetic	ADJ
k3569310801	6	28	disorders	disorder	NOUN
k3569310801	6	29	and	and	CCONJ
k3569310801	6	30	abnormalities	abnormality	NOUN
k3569310801	6	31	.	.	PUNCT
k3569310801	7	1	here	here	ADV
k3569310801	7	2	,	,	PUNCT
k3569310801	7	3	histidine	histidine	NOUN
k3569310801	7	4	-	-	PUNCT
k3569310801	7	5	rich	rich	ADJ
k3569310801	7	6	ionizable	ionizable	ADJ
k3569310801	7	7	lipids	lipid	NOUN
k3569310801	7	8	were	be	AUX
k3569310801	7	9	designed	design	VERB
k3569310801	7	10	for	for	ADP
k3569310801	7	11	peptide	peptide	NOUN
k3569310801	7	12	-	-	PUNCT
k3569310801	7	13	targeted	target	VERB
k3569310801	7	14	lipid	lipid	NOUN
k3569310801	7	15	-	-	PUNCT
k3569310801	7	16	based	base	VERB
k3569310801	7	17	nanoparticle	nanoparticle	NOUN
k3569310801	7	18	formulations	formulation	NOUN
k3569310801	7	19	and	and	CCONJ
k3569310801	7	20	were	be	AUX
k3569310801	7	21	evaluated	evaluate	VERB
k3569310801	7	22	in	in	ADP
k3569310801	7	23	multiple	multiple	ADJ
k3569310801	7	24	myeloma	myeloma	NOUN
k3569310801	7	25	and	and	CCONJ
k3569310801	7	26	breast	breast	NOUN
k3569310801	7	27	cancer	cancer	NOUN
k3569310801	7	28	using	use	VERB
k3569310801	7	29	biochemical	biochemical	ADJ
k3569310801	7	30	and	and	CCONJ
k3569310801	7	31	cell	cell	NOUN
k3569310801	7	32	-	-	PUNCT
k3569310801	7	33	based	base	VERB
k3569310801	7	34	assays	assay	NOUN
k3569310801	7	35	to	to	PART
k3569310801	7	36	achieve	achieve	VERB
k3569310801	7	37	endosomal	endosomal	ADJ
k3569310801	7	38	escape	escape	NOUN
k3569310801	7	39	in	in	ADP
k3569310801	7	40	vitro	vitro	X
k3569310801	7	41	.	.	PUNCT
k3569310801	8	1	in	in	ADP
k3569310801	8	2	chapter	chapter	NOUN
k3569310801	8	3	5	5	NUM
k3569310801	8	4	,	,	PUNCT
k3569310801	8	5	the	the	DET
k3569310801	8	6	importance	importance	NOUN
k3569310801	8	7	of	of	ADP
k3569310801	8	8	targeting	target	VERB
k3569310801	8	9	tumor	tumor	NOUN
k3569310801	8	10	associated	associate	VERB
k3569310801	8	11	macrophages	macrophage	NOUN
k3569310801	8	12	has	have	AUX
k3569310801	8	13	been	be	AUX
k3569310801	8	14	described	describe	VERB
k3569310801	8	15	and	and	CCONJ
k3569310801	8	16	peptide	peptide	NOUN
k3569310801	8	17	-	-	PUNCT
k3569310801	8	18	targeted	target	VERB
k3569310801	8	19	liposomal	liposomal	ADJ
k3569310801	8	20	nanoparticle	nanoparticle	NOUN
k3569310801	8	21	formulations	formulation	NOUN
k3569310801	8	22	were	be	AUX
k3569310801	8	23	developed	develop	VERB
k3569310801	8	24	to	to	PART
k3569310801	8	25	specifically	specifically	ADV
k3569310801	8	26	reprogram	reprogram	VERB
k3569310801	8	27	pro	pro	ADJ
k3569310801	8	28	-	-	ADJ
k3569310801	8	29	tumorigenic	tumorigenic	ADJ
k3569310801	8	30	macrophages	macrophage	NOUN
k3569310801	8	31	.	.	PUNCT
k3569310801	9	1	moreover	moreover	ADV
k3569310801	9	2	,	,	PUNCT
k3569310801	9	3	sirna	sirna	PROPN
k3569310801	9	4	loaded	load	VERB
k3569310801	9	5	targeted	target	VERB
k3569310801	9	6	nanoparticle	nanoparticle	NOUN
k3569310801	9	7	formulations	formulation	NOUN
k3569310801	9	8	demonstrated	demonstrate	VERB
k3569310801	9	9	significantly	significantly	ADV
k3569310801	9	10	reduced	reduce	VERB
k3569310801	9	11	tumor	tumor	NOUN
k3569310801	9	12	burden	burden	NOUN
k3569310801	9	13	in	in	ADP
k3569310801	9	14	an	an	DET
k3569310801	9	15	aggressive	aggressive	ADJ
k3569310801	9	16	lung	lung	NOUN
k3569310801	9	17	tumor	tumor	NOUN
k3569310801	9	18	model	model	NOUN
k3569310801	9	19	.	.	PUNCT
k3569310801	10	1	my	my	PRON
k3569310801	10	2	research	research	NOUN
k3569310801	10	3	has	have	VERB
k3569310801	10	4	the	the	DET
k3569310801	10	5	potential	potential	NOUN
k3569310801	10	6	to	to	PART
k3569310801	10	7	significantly	significantly	ADV
k3569310801	10	8	enhance	enhance	VERB
k3569310801	10	9	clinical	clinical	ADJ
k3569310801	10	10	prognosis	prognosis	NOUN
k3569310801	10	11	by	by	ADP
k3569310801	10	12	delivering	deliver	VERB
k3569310801	10	13	therapeutics	therapeutic	NOUN
k3569310801	10	14	selectively	selectively	ADV
k3569310801	10	15	and	and	CCONJ
k3569310801	10	16	safely	safely	ADV
k3569310801	10	17	and	and	CCONJ
k3569310801	10	18	improving	improve	VERB
k3569310801	10	19	the	the	DET
k3569310801	10	20	quality	quality	NOUN
k3569310801	10	21	of	of	ADP
k3569310801	10	22	patients	patient	NOUN
k3569310801	10	23	'	'	PART
k3569310801	10	24	lives	life	NOUN
k3569310801	10	25	.	.	PUNCT
k3569310801	11	1	furthermore	furthermore	ADV
k3569310801	11	2	,	,	PUNCT
k3569310801	11	3	the	the	DET
k3569310801	11	4	approaches	approach	NOUN
k3569310801	11	5	described	describe	VERB
k3569310801	11	6	in	in	ADP
k3569310801	11	7	this	this	DET
k3569310801	11	8	thesis	thesis	NOUN
k3569310801	11	9	have	have	VERB
k3569310801	11	10	the	the	DET
k3569310801	11	11	possibility	possibility	NOUN
k3569310801	11	12	to	to	PART
k3569310801	11	13	overcome	overcome	VERB
k3569310801	11	14	existing	exist	VERB
k3569310801	11	15	challenges	challenge	NOUN
k3569310801	11	16	of	of	ADP
k3569310801	11	17	poor	poor	ADJ
k3569310801	11	18	clinical	clinical	ADJ
k3569310801	11	19	outcomes	outcome	NOUN
k3569310801	11	20	in	in	ADP
k3569310801	11	21	cancer	cancer	NOUN
k3569310801	11	22	treatments	treatment	NOUN
k3569310801	11	23	,	,	PUNCT
k3569310801	11	24	such	such	ADJ
k3569310801	11	25	as	as	ADP
k3569310801	11	26	less	less	ADV
k3569310801	11	27	effective	effective	ADJ
k3569310801	11	28	treatment	treatment	NOUN
k3569310801	11	29	,	,	PUNCT
k3569310801	11	30	shorter	short	ADJ
k3569310801	11	31	life	life	NOUN
k3569310801	11	32	expectancy	expectancy	NOUN
k3569310801	11	33	,	,	PUNCT
k3569310801	11	34	poorer	poor	ADJ
k3569310801	11	35	prognosis	prognosis	NOUN
k3569310801	11	36	,	,	PUNCT
k3569310801	11	37	and	and	CCONJ
k3569310801	11	38	greater	great	ADJ
k3569310801	11	39	risk	risk	NOUN
k3569310801	11	40	of	of	ADP
k3569310801	11	41	cancer	cancer	NOUN
k3569310801	11	42	relapse	relapse	NOUN
k3569310801	11	43	in	in	ADP
k3569310801	11	44	already	already	ADV
k3569310801	11	45	suffering	suffer	VERB
k3569310801	11	46	patients	patient	NOUN
k3569310801	11	47	.	.	PUNCT
k3569310801	12	1	the	the	DET
k3569310801	12	2	majority	majority	NOUN
k3569310801	12	3	of	of	ADP
k3569310801	12	4	nanomedicine	nanomedicine	NOUN
k3569310801	12	5	used	use	VERB
k3569310801	12	6	in	in	ADP
k3569310801	12	7	cancer	cancer	NOUN
k3569310801	12	8	treatment	treatment	NOUN
k3569310801	12	9	,	,	PUNCT
k3569310801	12	10	vaccination	vaccination	NOUN
k3569310801	12	11	,	,	PUNCT
k3569310801	12	12	diagnostics	diagnostic	NOUN
k3569310801	12	13	,	,	PUNCT
k3569310801	12	14	fungal	fungal	ADJ
k3569310801	12	15	treatment	treatment	NOUN
k3569310801	12	16	,	,	PUNCT
k3569310801	12	17	or	or	CCONJ
k3569310801	12	18	analgesics	analgesic	NOUN
k3569310801	12	19	,	,	PUNCT
k3569310801	12	20	are	be	AUX
k3569310801	12	21	fda	fda	PROPN
k3569310801	12	22	-	-	PUNCT
k3569310801	12	23	approved	approve	VERB
k3569310801	12	24	lipid	lipid	NOUN
k3569310801	12	25	-	-	PUNCT
k3569310801	12	26	based	base	VERB
k3569310801	12	27	nanoparticles	nanoparticle	NOUN
k3569310801	12	28	,	,	PUNCT
k3569310801	12	29	that	that	PRON
k3569310801	12	30	have	have	AUX
k3569310801	12	31	not	not	PART
k3569310801	12	32	been	be	AUX
k3569310801	12	33	targeted	target	VERB
k3569310801	12	34	yet	yet	ADV
k3569310801	12	35	.	.	PUNCT
k3569310801	13	1	since	since	SCONJ
k3569310801	13	2	the	the	DET
k3569310801	13	3	first	first	ADJ
k3569310801	13	4	approval	approval	NOUN
k3569310801	13	5	of	of	ADP
k3569310801	13	6	doxil	doxil	NOUN
k3569310801	13	7	in	in	ADP
k3569310801	13	8	1995	1995	NUM
k3569310801	13	9	,	,	PUNCT
k3569310801	13	10	nanomedicine	nanomedicine	NOUN
k3569310801	13	11	has	have	AUX
k3569310801	13	12	garnered	garner	VERB
k3569310801	13	13	attention	attention	NOUN
k3569310801	13	14	and	and	CCONJ
k3569310801	13	15	more	more	ADJ
k3569310801	13	16	startups	startup	NOUN
k3569310801	13	17	and	and	CCONJ
k3569310801	13	18	top	top	ADJ
k3569310801	13	19	-	-	PUNCT
k3569310801	13	20	notch	notch	NOUN
k3569310801	13	21	biotech	biotech	NOUN
k3569310801	13	22	-	-	PUNCT
k3569310801	13	23	based	base	VERB
k3569310801	13	24	companies	company	NOUN
k3569310801	13	25	are	be	AUX
k3569310801	13	26	fiercely	fiercely	ADV
k3569310801	13	27	pursuing	pursue	VERB
k3569310801	13	28	lipid	lipid	NOUN
k3569310801	13	29	-	-	PUNCT
k3569310801	13	30	based	base	VERB
k3569310801	13	31	therapeutics	therapeutic	NOUN
k3569310801	13	32	in	in	ADP
k3569310801	13	33	clinical	clinical	ADJ
k3569310801	13	34	investigations	investigation	NOUN
k3569310801	13	35	.	.	PUNCT
k3569310801	14	1	since	since	SCONJ
k3569310801	14	2	now	now	ADV
k3569310801	14	3	we	we	PRON
k3569310801	14	4	have	have	VERB
k3569310801	14	5	information	information	NOUN
k3569310801	14	6	about	about	ADP
k3569310801	14	7	the	the	DET
k3569310801	14	8	human	human	ADJ
k3569310801	14	9	genome	genome	NOUN
k3569310801	14	10	and	and	CCONJ
k3569310801	14	11	advanced	advanced	ADJ
k3569310801	14	12	tools	tool	NOUN
k3569310801	14	13	to	to	PART
k3569310801	14	14	adjust	adjust	VERB
k3569310801	14	15	therapeutics	therapeutic	NOUN
k3569310801	14	16	according	accord	VERB
k3569310801	14	17	to	to	ADP
k3569310801	14	18	tumor	tumor	NOUN
k3569310801	14	19	heterogeneity	heterogeneity	NOUN
k3569310801	14	20	and	and	CCONJ
k3569310801	14	21	molecularly	molecularly	ADV
k3569310801	14	22	defined	define	VERB
k3569310801	14	23	populations	population	NOUN
k3569310801	14	24	,	,	PUNCT
k3569310801	14	25	there	there	PRON
k3569310801	14	26	are	be	VERB
k3569310801	14	27	exciting	exciting	ADJ
k3569310801	14	28	opportunities	opportunity	NOUN
k3569310801	14	29	and	and	CCONJ
k3569310801	14	30	potentials	potential	NOUN
k3569310801	14	31	to	to	PART
k3569310801	14	32	bring	bring	VERB
k3569310801	14	33	more	more	ADJ
k3569310801	14	34	innovative	innovative	ADJ
k3569310801	14	35	nanomedicine	nanomedicine	NOUN
k3569310801	14	36	therapies	therapy	NOUN
k3569310801	14	37	for	for	ADP
k3569310801	14	38	effective	effective	ADJ
k3569310801	14	39	treatment	treatment	NOUN
k3569310801	14	40	in	in	ADP
k3569310801	14	41	the	the	DET
k3569310801	14	42	future	future	NOUN
k3569310801	14	43	.	.	PUNCT