id	sid	tid	token	lemma	pos
k0698625s02	1	1	living	living	NOUN
k0698625s02	1	2	organisms	organism	NOUN
k0698625s02	1	3	are	be	AUX
k0698625s02	1	4	driven	drive	VERB
k0698625s02	1	5	by	by	ADP
k0698625s02	1	6	molecular	molecular	ADJ
k0698625s02	1	7	machines	machine	NOUN
k0698625s02	1	8	called	call	VERB
k0698625s02	1	9	proteins	protein	NOUN
k0698625s02	1	10	.	.	PUNCT
k0698625s02	2	1	to	to	PART
k0698625s02	2	2	understand	understand	VERB
k0698625s02	2	3	the	the	DET
k0698625s02	2	4	molecular	molecular	ADJ
k0698625s02	2	5	mechanisms	mechanism	NOUN
k0698625s02	2	6	of	of	ADP
k0698625s02	2	7	the	the	DET
k0698625s02	2	8	cell	cell	NOUN
k0698625s02	2	9	,	,	PUNCT
k0698625s02	2	10	it	it	PRON
k0698625s02	2	11	is	be	AUX
k0698625s02	2	12	not	not	PART
k0698625s02	2	13	enough	enough	ADJ
k0698625s02	2	14	to	to	PART
k0698625s02	2	15	understand	understand	VERB
k0698625s02	2	16	individual	individual	ADJ
k0698625s02	2	17	properties	property	NOUN
k0698625s02	2	18	and	and	CCONJ
k0698625s02	2	19	functions	function	NOUN
k0698625s02	2	20	of	of	ADP
k0698625s02	2	21	proteins	protein	NOUN
k0698625s02	2	22	but	but	CCONJ
k0698625s02	2	23	rather	rather	ADV
k0698625s02	2	24	uncover	uncover	VERB
k0698625s02	2	25	the	the	DET
k0698625s02	2	26	interactions	interaction	NOUN
k0698625s02	2	27	between	between	ADP
k0698625s02	2	28	these	these	DET
k0698625s02	2	29	molecules	molecule	NOUN
k0698625s02	2	30	.	.	PUNCT
k0698625s02	3	1	this	this	DET
k0698625s02	3	2	work	work	NOUN
k0698625s02	3	3	presents	present	VERB
k0698625s02	3	4	a	a	DET
k0698625s02	3	5	multiscale	multiscale	ADJ
k0698625s02	3	6	approach	approach	NOUN
k0698625s02	3	7	to	to	PART
k0698625s02	3	8	study	study	VERB
k0698625s02	3	9	protein	protein	NOUN
k0698625s02	3	10	networks	network	NOUN
k0698625s02	3	11	.	.	PUNCT
k0698625s02	4	1	the	the	DET
k0698625s02	4	2	top	top	ADJ
k0698625s02	4	3	scale	scale	NOUN
k0698625s02	4	4	introduces	introduce	VERB
k0698625s02	4	5	an	an	DET
k0698625s02	4	6	algorithm	algorithm	NOUN
k0698625s02	4	7	for	for	ADP
k0698625s02	4	8	protein	protein	NOUN
k0698625s02	4	9	and	and	CCONJ
k0698625s02	4	10	domain	domain	NOUN
k0698625s02	4	11	physical	physical	ADJ
k0698625s02	4	12	interaction	interaction	NOUN
k0698625s02	4	13	estimation	estimation	NOUN
k0698625s02	4	14	.	.	PUNCT
k0698625s02	5	1	this	this	DET
k0698625s02	5	2	algorithm	algorithm	PROPN
k0698625s02	5	3	is	be	AUX
k0698625s02	5	4	validated	validate	VERB
k0698625s02	5	5	in	in	ADP
k0698625s02	5	6	the	the	DET
k0698625s02	5	7	model	model	NOUN
k0698625s02	5	8	organism	organism	NOUN
k0698625s02	5	9	s.	s.	NOUN
k0698625s02	5	10	cerevisiae	cerevisiae	NOUN
k0698625s02	5	11	and	and	CCONJ
k0698625s02	5	12	applied	apply	VERB
k0698625s02	5	13	to	to	ADP
k0698625s02	5	14	the	the	DET
k0698625s02	5	15	soil	soil	NOUN
k0698625s02	5	16	bacterium	bacterium	NOUN
k0698625s02	5	17	m.	m.	NOUN
k0698625s02	5	18	xanthus	xanthus	PROPN
k0698625s02	5	19	.	.	PUNCT
k0698625s02	6	1	interactions	interaction	NOUN
k0698625s02	6	2	are	be	AUX
k0698625s02	6	3	predicted	predict	VERB
k0698625s02	6	4	in	in	ADP
k0698625s02	6	5	the	the	DET
k0698625s02	6	6	reversal	reversal	NOUN
k0698625s02	6	7	mechanism	mechanism	NOUN
k0698625s02	6	8	of	of	ADP
k0698625s02	6	9	this	this	DET
k0698625s02	6	10	bacterium	bacterium	NOUN
k0698625s02	6	11	,	,	PUNCT
k0698625s02	6	12	proposing	propose	VERB
k0698625s02	6	13	an	an	DET
k0698625s02	6	14	extended	extended	ADJ
k0698625s02	6	15	model	model	NOUN
k0698625s02	6	16	for	for	ADP
k0698625s02	6	17	reversal	reversal	NOUN
k0698625s02	6	18	control	control	NOUN
k0698625s02	6	19	and	and	CCONJ
k0698625s02	6	20	motility	motility	NOUN
k0698625s02	6	21	engine	engine	NOUN
k0698625s02	6	22	activation	activation	NOUN
k0698625s02	6	23	/	/	SYM
k0698625s02	6	24	deactivation	deactivation	NOUN
k0698625s02	6	25	.	.	PUNCT
k0698625s02	7	1	at	at	ADP
k0698625s02	7	2	a	a	DET
k0698625s02	7	3	second	second	ADJ
k0698625s02	7	4	scale	scale	NOUN
k0698625s02	7	5	,	,	PUNCT
k0698625s02	7	6	this	this	DET
k0698625s02	7	7	work	work	NOUN
k0698625s02	7	8	investigates	investigate	VERB
k0698625s02	7	9	the	the	DET
k0698625s02	7	10	problem	problem	NOUN
k0698625s02	7	11	of	of	ADP
k0698625s02	7	12	specificity	specificity	NOUN
k0698625s02	7	13	residue	residue	ADJ
k0698625s02	7	14	identification	identification	NOUN
k0698625s02	7	15	in	in	ADP
k0698625s02	7	16	a	a	DET
k0698625s02	7	17	bacterial	bacterial	ADJ
k0698625s02	7	18	signaling	signal	VERB
k0698625s02	7	19	pathway	pathway	NOUN
k0698625s02	7	20	called	call	VERB
k0698625s02	7	21	two	two	NUM
k0698625s02	7	22	component	component	NOUN
k0698625s02	7	23	system	system	NOUN
k0698625s02	7	24	.	.	PUNCT
k0698625s02	8	1	using	use	VERB
k0698625s02	8	2	a	a	DET
k0698625s02	8	3	method	method	NOUN
k0698625s02	8	4	of	of	ADP
k0698625s02	8	5	subgraph	subgraph	NOUN
k0698625s02	8	6	identification	identification	NOUN
k0698625s02	8	7	and	and	CCONJ
k0698625s02	8	8	learning	learning	NOUN
k0698625s02	8	9	,	,	PUNCT
k0698625s02	8	10	specificity	specificity	NOUN
k0698625s02	8	11	residues	residue	NOUN
k0698625s02	8	12	or	or	CCONJ
k0698625s02	8	13	'	'	PUNCT
k0698625s02	8	14	graphlets	graphlet	NOUN
k0698625s02	8	15	'	'	PUNCT
k0698625s02	8	16	are	be	AUX
k0698625s02	8	17	proposed	propose	VERB
k0698625s02	8	18	to	to	PART
k0698625s02	8	19	estimate	estimate	VERB
k0698625s02	8	20	factors	factor	NOUN
k0698625s02	8	21	contributing	contribute	VERB
k0698625s02	8	22	to	to	ADP
k0698625s02	8	23	domain	domain	NOUN
k0698625s02	8	24	-	-	PUNCT
k0698625s02	8	25	domain	domain	NOUN
k0698625s02	8	26	specificity	specificity	NOUN
k0698625s02	8	27	in	in	ADP
k0698625s02	8	28	histidine	histidine	NOUN
k0698625s02	8	29	kinases	kinase	NOUN
k0698625s02	8	30	and	and	CCONJ
k0698625s02	8	31	response	response	NOUN
k0698625s02	8	32	regulators	regulator	NOUN
k0698625s02	8	33	.	.	PUNCT
k0698625s02	9	1	this	this	DET
k0698625s02	9	2	network	network	NOUN
k0698625s02	9	3	based	base	VERB
k0698625s02	9	4	approach	approach	NOUN
k0698625s02	9	5	reproduced	reproduce	VERB
k0698625s02	9	6	experimental	experimental	ADJ
k0698625s02	9	7	studies	study	NOUN
k0698625s02	9	8	in	in	ADP
k0698625s02	9	9	e.	e.	PROPN
k0698625s02	9	10	coli	coli	PROPN
k0698625s02	9	11	and	and	CCONJ
k0698625s02	9	12	produced	produce	VERB
k0698625s02	9	13	a	a	DET
k0698625s02	9	14	series	series	NOUN
k0698625s02	9	15	of	of	ADP
k0698625s02	9	16	hypotheses	hypothesis	NOUN
k0698625s02	9	17	of	of	ADP
k0698625s02	9	18	domain	domain	NOUN
k0698625s02	9	19	specificity	specificity	NOUN
k0698625s02	9	20	that	that	PRON
k0698625s02	9	21	could	could	AUX
k0698625s02	9	22	extend	extend	VERB
k0698625s02	9	23	our	our	PRON
k0698625s02	9	24	knowledge	knowledge	NOUN
k0698625s02	9	25	of	of	ADP
k0698625s02	9	26	interaction	interaction	NOUN
k0698625s02	9	27	interfaces	interface	NOUN
k0698625s02	9	28	in	in	ADP
k0698625s02	9	29	two	two	NUM
k0698625s02	9	30	-	-	PUNCT
k0698625s02	9	31	component	component	NOUN
k0698625s02	9	32	systems	system	NOUN
k0698625s02	9	33	.	.	PUNCT
k0698625s02	10	1	at	at	ADP
k0698625s02	10	2	a	a	DET
k0698625s02	10	3	finer	fine	ADJ
k0698625s02	10	4	scale	scale	NOUN
k0698625s02	10	5	of	of	ADP
k0698625s02	10	6	individual	individual	ADJ
k0698625s02	10	7	atomic	atomic	ADJ
k0698625s02	10	8	protein	protein	NOUN
k0698625s02	10	9	structures	structure	NOUN
k0698625s02	10	10	,	,	PUNCT
k0698625s02	10	11	this	this	DET
k0698625s02	10	12	work	work	NOUN
k0698625s02	10	13	introduces	introduce	VERB
k0698625s02	10	14	a	a	DET
k0698625s02	10	15	methodology	methodology	NOUN
k0698625s02	10	16	to	to	PART
k0698625s02	10	17	identify	identify	VERB
k0698625s02	10	18	metastable	metastable	ADJ
k0698625s02	10	19	clusters	cluster	NOUN
k0698625s02	10	20	of	of	ADP
k0698625s02	10	21	atomic	atomic	ADJ
k0698625s02	10	22	conformations	conformation	NOUN
k0698625s02	10	23	obtained	obtain	VERB
k0698625s02	10	24	by	by	ADP
k0698625s02	10	25	combining	combine	VERB
k0698625s02	10	26	and	and	CCONJ
k0698625s02	10	27	correlating	correlate	VERB
k0698625s02	10	28	nuclear	nuclear	ADJ
k0698625s02	10	29	magnetic	magnetic	ADJ
k0698625s02	10	30	resonance	resonance	NOUN
k0698625s02	10	31	(	(	PUNCT
k0698625s02	10	32	nmr	nmr	NOUN
k0698625s02	10	33	)	)	PUNCT
k0698625s02	10	34	experimental	experimental	ADJ
k0698625s02	10	35	data	datum	NOUN
k0698625s02	10	36	with	with	ADP
k0698625s02	10	37	molecular	molecular	ADJ
k0698625s02	10	38	dynamics	dynamic	NOUN
k0698625s02	10	39	simulation	simulation	NOUN
k0698625s02	10	40	.	.	PUNCT
k0698625s02	11	1	this	this	DET
k0698625s02	11	2	methodology	methodology	NOUN
k0698625s02	11	3	provides	provide	VERB
k0698625s02	11	4	a	a	DET
k0698625s02	11	5	way	way	NOUN
k0698625s02	11	6	to	to	PART
k0698625s02	11	7	find	find	VERB
k0698625s02	11	8	a	a	DET
k0698625s02	11	9	network	network	NOUN
k0698625s02	11	10	of	of	ADP
k0698625s02	11	11	metastable	metastable	ADJ
k0698625s02	11	12	states	state	NOUN
k0698625s02	11	13	(	(	PUNCT
k0698625s02	11	14	nodes	nodes	PROPN
k0698625s02	11	15	)	)	PUNCT
k0698625s02	11	16	and	and	CCONJ
k0698625s02	11	17	their	their	PRON
k0698625s02	11	18	most	most	ADV
k0698625s02	11	19	visited	visit	VERB
k0698625s02	11	20	transitions	transition	NOUN
k0698625s02	11	21	(	(	PUNCT
k0698625s02	11	22	links	link	NOUN
k0698625s02	11	23	)	)	PUNCT
k0698625s02	11	24	.	.	PUNCT
k0698625s02	12	1	this	this	PRON
k0698625s02	12	2	represents	represent	VERB
k0698625s02	12	3	a	a	DET
k0698625s02	12	4	mechanistic	mechanistic	ADJ
k0698625s02	12	5	view	view	NOUN
k0698625s02	12	6	of	of	ADP
k0698625s02	12	7	conformation	conformation	NOUN
k0698625s02	12	8	change	change	NOUN
k0698625s02	12	9	in	in	ADP
k0698625s02	12	10	a	a	DET
k0698625s02	12	11	given	give	VERB
k0698625s02	12	12	protein	protein	NOUN
k0698625s02	12	13	.	.	PUNCT
k0698625s02	13	1	this	this	DET
k0698625s02	13	2	analysis	analysis	NOUN
k0698625s02	13	3	is	be	AUX
k0698625s02	13	4	applied	apply	VERB
k0698625s02	13	5	to	to	ADP
k0698625s02	13	6	the	the	DET
k0698625s02	13	7	ww	ww	PROPN
k0698625s02	13	8	domain	domain	NOUN
k0698625s02	13	9	of	of	ADP
k0698625s02	13	10	human	human	ADJ
k0698625s02	13	11	protein	protein	NOUN
k0698625s02	13	12	pin1	pin1	NOUN
k0698625s02	13	13	.	.	PUNCT
k0698625s02	14	1	in	in	ADP
k0698625s02	14	2	addition	addition	NOUN
k0698625s02	14	3	to	to	ADP
k0698625s02	14	4	high	high	ADJ
k0698625s02	14	5	correlation	correlation	NOUN
k0698625s02	14	6	with	with	ADP
k0698625s02	14	7	nmr	nmr	PROPN
k0698625s02	14	8	exchange	exchange	NOUN
k0698625s02	14	9	rates	rate	NOUN
k0698625s02	14	10	,	,	PUNCT
k0698625s02	14	11	the	the	DET
k0698625s02	14	12	network	network	NOUN
k0698625s02	14	13	of	of	ADP
k0698625s02	14	14	kinetic	kinetic	ADJ
k0698625s02	14	15	macrostates	macrostate	NOUN
k0698625s02	14	16	identified	identify	VERB
k0698625s02	14	17	here	here	ADV
k0698625s02	14	18	proposes	propose	VERB
k0698625s02	14	19	that	that	SCONJ
k0698625s02	14	20	pin1	pin1	NOUN
k0698625s02	14	21	-	-	PUNCT
k0698625s02	14	22	ww	ww	NOUN
k0698625s02	14	23	domain	domain	NOUN
k0698625s02	14	24	in	in	ADP
k0698625s02	14	25	unbound	unbound	ADJ
k0698625s02	14	26	state	state	NOUN
k0698625s02	14	27	visits	visit	VERB
k0698625s02	14	28	its	its	PRON
k0698625s02	14	29	bound	bound	ADJ
k0698625s02	14	30	configuration	configuration	NOUN
k0698625s02	14	31	through	through	ADP
k0698625s02	14	32	a	a	DET
k0698625s02	14	33	state	state	NOUN
k0698625s02	14	34	that	that	PRON
k0698625s02	14	35	corresponds	correspond	VERB
k0698625s02	14	36	to	to	ADP
k0698625s02	14	37	a	a	DET
k0698625s02	14	38	minor	minor	ADJ
k0698625s02	14	39	population	population	NOUN
k0698625s02	14	40	of	of	ADP
k0698625s02	14	41	relaxation	relaxation	NOUN
k0698625s02	14	42	dispersion	dispersion	NOUN
k0698625s02	14	43	experiments	experiment	NOUN
k0698625s02	14	44	.	.	PUNCT
k0698625s02	15	1	this	this	DET
k0698625s02	15	2	computational	computational	ADJ
k0698625s02	15	3	approach	approach	NOUN
k0698625s02	15	4	provides	provide	VERB
k0698625s02	15	5	a	a	DET
k0698625s02	15	6	detailed	detailed	ADJ
k0698625s02	15	7	structural	structural	ADJ
k0698625s02	15	8	view	view	NOUN
k0698625s02	15	9	of	of	ADP
k0698625s02	15	10	conformational	conformational	ADJ
k0698625s02	15	11	change	change	NOUN
k0698625s02	15	12	that	that	PRON
k0698625s02	15	13	nrm	nrm	DET
k0698625s02	15	14	experiments	experiment	NOUN
k0698625s02	15	15	are	be	AUX
k0698625s02	15	16	not	not	PART
k0698625s02	15	17	able	able	ADJ
k0698625s02	15	18	to	to	PART
k0698625s02	15	19	identify	identify	VERB
k0698625s02	15	20	.	.	PUNCT
k0698625s02	16	1	this	this	DET
k0698625s02	16	2	dissertation	dissertation	NOUN
k0698625s02	16	3	introduces	introduce	VERB
k0698625s02	16	4	novel	novel	ADJ
k0698625s02	16	5	methodologies	methodology	NOUN
k0698625s02	16	6	that	that	PRON
k0698625s02	16	7	were	be	AUX
k0698625s02	16	8	validated	validate	VERB
k0698625s02	16	9	using	use	VERB
k0698625s02	16	10	experimental	experimental	ADJ
k0698625s02	16	11	data	datum	NOUN
k0698625s02	16	12	and	and	CCONJ
k0698625s02	16	13	can	can	AUX
k0698625s02	16	14	be	be	AUX
k0698625s02	16	15	generally	generally	ADV
k0698625s02	16	16	applied	apply	VERB
k0698625s02	16	17	to	to	ADP
k0698625s02	16	18	different	different	ADJ
k0698625s02	16	19	organisms	organism	NOUN
k0698625s02	16	20	.	.	PUNCT
k0698625s02	17	1	these	these	DET
k0698625s02	17	2	methodologies	methodology	NOUN
k0698625s02	17	3	propose	propose	VERB
k0698625s02	17	4	testable	testable	ADJ
k0698625s02	17	5	hypotheses	hypothesis	NOUN
k0698625s02	17	6	that	that	PRON
k0698625s02	17	7	could	could	AUX
k0698625s02	17	8	improve	improve	VERB
k0698625s02	17	9	our	our	PRON
k0698625s02	17	10	knowledge	knowledge	NOUN
k0698625s02	17	11	of	of	ADP
k0698625s02	17	12	biological	biological	ADJ
k0698625s02	17	13	problems	problem	NOUN
k0698625s02	17	14	and	and	CCONJ
k0698625s02	17	15	systems	system	NOUN
k0698625s02	17	16	.	.	PUNCT