id sid tid token lemma pos jw827942h2c 1 1 the the DET jw827942h2c 1 2 zebrafish zebrafish NOUN jw827942h2c 1 3 is be AUX jw827942h2c 1 4 an an DET jw827942h2c 1 5 excellent excellent ADJ jw827942h2c 1 6 model model NOUN jw827942h2c 1 7 organism organism NOUN jw827942h2c 1 8 to to PART jw827942h2c 1 9 use use VERB jw827942h2c 1 10 in in ADP jw827942h2c 1 11 the the DET jw827942h2c 1 12 study study NOUN jw827942h2c 1 13 of of ADP jw827942h2c 1 14 molecular molecular ADJ jw827942h2c 1 15 pathways pathway NOUN jw827942h2c 1 16 important important ADJ jw827942h2c 1 17 in in ADP jw827942h2c 1 18 both both CCONJ jw827942h2c 1 19 retinal retinal ADJ jw827942h2c 1 20 development development NOUN jw827942h2c 1 21 and and CCONJ jw827942h2c 1 22 neuronal neuronal ADJ jw827942h2c 1 23 regeneration regeneration NOUN jw827942h2c 1 24 . . PUNCT jw827942h2c 2 1 the the DET jw827942h2c 2 2 zebrafish zebrafish NOUN jw827942h2c 2 3 shares share NOUN jw827942h2c 2 4 similarities similarity NOUN jw827942h2c 2 5 in in ADP jw827942h2c 2 6 eye eye NOUN jw827942h2c 2 7 development development NOUN jw827942h2c 2 8 and and CCONJ jw827942h2c 2 9 morphology morphology NOUN jw827942h2c 2 10 with with ADP jw827942h2c 2 11 all all DET jw827942h2c 2 12 vertebrate vertebrate ADJ jw827942h2c 2 13 eyes eye NOUN jw827942h2c 2 14 . . PUNCT jw827942h2c 3 1 however however ADV jw827942h2c 3 2 , , PUNCT jw827942h2c 3 3 unlike unlike ADP jw827942h2c 3 4 the the DET jw827942h2c 3 5 mammalian mammalian PROPN jw827942h2c 3 6 retina retina NOUN jw827942h2c 3 7 , , PUNCT jw827942h2c 3 8 the the DET jw827942h2c 3 9 zebrafish zebrafish NOUN jw827942h2c 3 10 completely completely ADV jw827942h2c 3 11 regenerates regenerate VERB jw827942h2c 3 12 retinal retinal ADJ jw827942h2c 3 13 neurons neuron NOUN jw827942h2c 3 14 following follow VERB jw827942h2c 3 15 injury injury NOUN jw827942h2c 3 16 . . PUNCT jw827942h2c 4 1 the the DET jw827942h2c 4 2 source source NOUN jw827942h2c 4 3 of of ADP jw827942h2c 4 4 regeneration regeneration NOUN jw827942h2c 4 5 are be AUX jw827942h2c 4 6 m?ller m?ller SPACE jw827942h2c 4 7 glial glial ADJ jw827942h2c 4 8 cells cell NOUN jw827942h2c 4 9 that that PRON jw827942h2c 4 10 dedifferentiate dedifferentiate NOUN jw827942h2c 4 11 into into ADP jw827942h2c 4 12 a a DET jw827942h2c 4 13 more more ADV jw827942h2c 4 14 primordial primordial ADJ jw827942h2c 4 15 stem stem NOUN jw827942h2c 4 16 cell cell NOUN jw827942h2c 4 17 - - PUNCT jw827942h2c 4 18 like like ADJ jw827942h2c 4 19 state state NOUN jw827942h2c 4 20 , , PUNCT jw827942h2c 4 21 divide divide NOUN jw827942h2c 4 22 , , PUNCT jw827942h2c 4 23 and and CCONJ jw827942h2c 4 24 yield yield VERB jw827942h2c 4 25 transiently transiently ADV jw827942h2c 4 26 amplifying amplify VERB jw827942h2c 4 27 progenitor progenitor NOUN jw827942h2c 4 28 cells cell NOUN jw827942h2c 4 29 that that PRON jw827942h2c 4 30 migrate migrate VERB jw827942h2c 4 31 to to ADP jw827942h2c 4 32 the the DET jw827942h2c 4 33 site site NOUN jw827942h2c 4 34 of of ADP jw827942h2c 4 35 damage damage NOUN jw827942h2c 4 36 and and CCONJ jw827942h2c 4 37 replenish replenish VERB jw827942h2c 4 38 the the DET jw827942h2c 4 39 lost lose VERB jw827942h2c 4 40 neuronal neuronal ADJ jw827942h2c 4 41 cell cell NOUN jw827942h2c 4 42 types type NOUN jw827942h2c 4 43 . . PUNCT jw827942h2c 5 1 dedifferentiating dedifferentiate VERB jw827942h2c 5 2 m?ller m?ller PUNCT jw827942h2c 5 3 glia glia NOUN jw827942h2c 5 4 in in ADP jw827942h2c 5 5 the the DET jw827942h2c 5 6 adult adult NOUN jw827942h2c 5 7 zebrafish zebrafish NOUN jw827942h2c 5 8 retina retina NOUN jw827942h2c 5 9 experience experience NOUN jw827942h2c 5 10 reprogramming reprogramming NOUN jw827942h2c 5 11 in in ADP jw827942h2c 5 12 dna dna NOUN jw827942h2c 5 13 methylation methylation NOUN jw827942h2c 5 14 and and CCONJ jw827942h2c 5 15 expression expression NOUN jw827942h2c 5 16 of of ADP jw827942h2c 5 17 transcription transcription NOUN jw827942h2c 5 18 factors factor NOUN jw827942h2c 5 19 that that PRON jw827942h2c 5 20 are be AUX jw827942h2c 5 21 involved involve VERB jw827942h2c 5 22 during during ADP jw827942h2c 5 23 normal normal ADJ jw827942h2c 5 24 retinal retinal ADJ jw827942h2c 5 25 development development NOUN jw827942h2c 5 26 ( ( PUNCT jw827942h2c 5 27 pollak pollak PROPN jw827942h2c 5 28 et et PROPN jw827942h2c 5 29 al al PROPN jw827942h2c 5 30 . . PROPN jw827942h2c 5 31 , , PUNCT jw827942h2c 5 32 2013 2013 NUM jw827942h2c 5 33 ; ; PUNCT jw827942h2c 5 34 powell powell PROPN jw827942h2c 5 35 et et PROPN jw827942h2c 5 36 al al PROPN jw827942h2c 5 37 . . PROPN jw827942h2c 5 38 , , PUNCT jw827942h2c 5 39 2013 2013 NUM jw827942h2c 5 40 ) ) PUNCT jw827942h2c 5 41 . . PUNCT jw827942h2c 6 1 therefore therefore ADV jw827942h2c 6 2 , , PUNCT jw827942h2c 6 3 studying study VERB jw827942h2c 6 4 the the DET jw827942h2c 6 5 cellular cellular ADJ jw827942h2c 6 6 and and CCONJ jw827942h2c 6 7 molecular molecular ADJ jw827942h2c 6 8 pathways pathway NOUN jw827942h2c 6 9 important important ADJ jw827942h2c 6 10 during during ADP jw827942h2c 6 11 retinal retinal ADJ jw827942h2c 6 12 development development NOUN jw827942h2c 6 13 may may AUX jw827942h2c 6 14 provide provide VERB jw827942h2c 6 15 insight insight NOUN jw827942h2c 6 16 into into ADP jw827942h2c 6 17 the the DET jw827942h2c 6 18 roles role NOUN jw827942h2c 6 19 these these DET jw827942h2c 6 20 genes gene NOUN jw827942h2c 6 21 play play VERB jw827942h2c 6 22 during during ADP jw827942h2c 6 23 regeneration regeneration NOUN jw827942h2c 6 24 in in ADP jw827942h2c 6 25 the the DET jw827942h2c 6 26 adult adult NOUN jw827942h2c 6 27 retina retina NOUN jw827942h2c 6 28 . . PUNCT jw827942h2c 7 1 in in ADP jw827942h2c 7 2 an an DET jw827942h2c 7 3 effort effort NOUN jw827942h2c 7 4 to to PART jw827942h2c 7 5 identify identify VERB jw827942h2c 7 6 pathways pathway NOUN jw827942h2c 7 7 involved involve VERB jw827942h2c 7 8 in in ADP jw827942h2c 7 9 early early ADJ jw827942h2c 7 10 retinal retinal ADJ jw827942h2c 7 11 development development NOUN jw827942h2c 7 12 in in ADP jw827942h2c 7 13 zebrafish zebrafish NOUN jw827942h2c 7 14 , , PUNCT jw827942h2c 7 15 a a DET jw827942h2c 7 16 gene gene NOUN jw827942h2c 7 17 microarray microarray NOUN jw827942h2c 7 18 analysis analysis NOUN jw827942h2c 7 19 was be AUX jw827942h2c 7 20 performed perform VERB jw827942h2c 7 21 , , PUNCT jw827942h2c 7 22 which which PRON jw827942h2c 7 23 demonstrated demonstrate VERB jw827942h2c 7 24 a a DET jw827942h2c 7 25 significant significant ADJ jw827942h2c 7 26 up up ADP jw827942h2c 7 27 regulation regulation NOUN jw827942h2c 7 28 in in ADP jw827942h2c 7 29 components component NOUN jw827942h2c 7 30 of of ADP jw827942h2c 7 31 the the DET jw827942h2c 7 32 jak jak X jw827942h2c 7 33 / / SYM jw827942h2c 7 34 stat3 stat3 NOUN jw827942h2c 7 35 pathway pathway NOUN jw827942h2c 7 36 , , PUNCT jw827942h2c 7 37 including include VERB jw827942h2c 7 38 socs3a socs3a PROPN jw827942h2c 7 39 and and CCONJ jw827942h2c 7 40 socs1 socs1 PROPN jw827942h2c 7 41 . . PUNCT jw827942h2c 8 1 immunoblots immunoblot NOUN jw827942h2c 8 2 , , PUNCT jw827942h2c 8 3 immunohistochemistry immunohistochemistry NOUN jw827942h2c 8 4 , , PUNCT jw827942h2c 8 5 and and CCONJ jw827942h2c 8 6 in in ADP jw827942h2c 8 7 situ situ ADJ jw827942h2c 8 8 hybridization hybridization NOUN jw827942h2c 8 9 data datum NOUN jw827942h2c 8 10 confirmed confirm VERB jw827942h2c 8 11 that that SCONJ jw827942h2c 8 12 stat3 stat3 NOUN jw827942h2c 8 13 , , PUNCT jw827942h2c 8 14 socs3a socs3a PROPN jw827942h2c 8 15 , , PUNCT jw827942h2c 8 16 and and CCONJ jw827942h2c 8 17 socs1 socs1 NOUN jw827942h2c 8 18 were be AUX jw827942h2c 8 19 up up ADV jw827942h2c 8 20 regulated regulate VERB jw827942h2c 8 21 in in ADP jw827942h2c 8 22 the the DET jw827942h2c 8 23 zebrafish zebrafish ADJ jw827942h2c 8 24 eye eye NOUN jw827942h2c 8 25 between between ADP jw827942h2c 8 26 3 3 NUM jw827942h2c 8 27 - - SYM jw827942h2c 8 28 5 5 NUM jw827942h2c 8 29 days day NOUN jw827942h2c 8 30 post post NOUN jw827942h2c 8 31 - - NOUN jw827942h2c 8 32 fertilization fertilization NOUN jw827942h2c 8 33 , , PUNCT jw827942h2c 8 34 time time NOUN jw827942h2c 8 35 points point NOUN jw827942h2c 8 36 associated associate VERB jw827942h2c 8 37 with with ADP jw827942h2c 8 38 significant significant ADJ jw827942h2c 8 39 maturation maturation NOUN jw827942h2c 8 40 of of ADP jw827942h2c 8 41 vision vision NOUN jw827942h2c 8 42 . . PUNCT jw827942h2c 9 1 stat3 stat3 NOUN jw827942h2c 9 2 , , PUNCT jw827942h2c 9 3 socs3a socs3a PROPN jw827942h2c 9 4 , , PUNCT jw827942h2c 9 5 and and CCONJ jw827942h2c 9 6 socs1 socs1 NOUN jw827942h2c 9 7 are be AUX jw827942h2c 9 8 initially initially ADV jw827942h2c 9 9 expressed express VERB jw827942h2c 9 10 ubiquitously ubiquitously ADV jw827942h2c 9 11 throughout throughout ADP jw827942h2c 9 12 the the DET jw827942h2c 9 13 developing develop VERB jw827942h2c 9 14 retina retina NOUN jw827942h2c 9 15 before before ADP jw827942h2c 9 16 showing show VERB jw827942h2c 9 17 a a DET jw827942h2c 9 18 distinct distinct ADJ jw827942h2c 9 19 localization localization NOUN jw827942h2c 9 20 within within ADP jw827942h2c 9 21 m?ller m?ller SPACE jw827942h2c 9 22 glial glial ADJ jw827942h2c 9 23 cells cell NOUN jw827942h2c 9 24 . . PUNCT jw827942h2c 10 1 morpholino morpholino ADJ jw827942h2c 10 2 - - PUNCT jw827942h2c 10 3 mediated mediate VERB jw827942h2c 10 4 knockdown knockdown NOUN jw827942h2c 10 5 of of ADP jw827942h2c 10 6 stat3 stat3 PROPN jw827942h2c 10 7 , , PUNCT jw827942h2c 10 8 socs3a socs3a PROPN jw827942h2c 10 9 , , PUNCT jw827942h2c 10 10 or or CCONJ jw827942h2c 10 11 socs1 socs1 PROPN jw827942h2c 10 12 demonstrated demonstrate VERB jw827942h2c 10 13 that that SCONJ jw827942h2c 10 14 a a DET jw827942h2c 10 15 loss loss NOUN jw827942h2c 10 16 of of ADP jw827942h2c 10 17 jak jak PROPN jw827942h2c 10 18 / / SYM jw827942h2c 10 19 stat3 stat3 NOUN jw827942h2c 10 20 function function NOUN jw827942h2c 10 21 caused cause VERB jw827942h2c 10 22 abnormal abnormal ADJ jw827942h2c 10 23 retinal retinal ADJ jw827942h2c 10 24 cell cell NOUN jw827942h2c 10 25 death death NOUN jw827942h2c 10 26 during during ADP jw827942h2c 10 27 development development NOUN jw827942h2c 10 28 . . PUNCT jw827942h2c 11 1 a a DET jw827942h2c 11 2 loss loss NOUN jw827942h2c 11 3 of of ADP jw827942h2c 11 4 either either CCONJ jw827942h2c 11 5 socs1 socs1 NOUN jw827942h2c 11 6 or or CCONJ jw827942h2c 11 7 socs3a socs3a PROPN jw827942h2c 11 8 resulted result VERB jw827942h2c 11 9 in in ADP jw827942h2c 11 10 decreased decrease VERB jw827942h2c 11 11 rhodopsin rhodopsin NOUN jw827942h2c 11 12 expression expression NOUN jw827942h2c 11 13 near near ADP jw827942h2c 11 14 the the DET jw827942h2c 11 15 retinal retinal ADJ jw827942h2c 11 16 margins margin NOUN jw827942h2c 11 17 of of ADP jw827942h2c 11 18 the the DET jw827942h2c 11 19 developing develop VERB jw827942h2c 11 20 zebrafish zebrafish NOUN jw827942h2c 11 21 , , PUNCT jw827942h2c 11 22 while while SCONJ jw827942h2c 11 23 and and CCONJ jw827942h2c 11 24 a a DET jw827942h2c 11 25 loss loss NOUN jw827942h2c 11 26 of of ADP jw827942h2c 11 27 stat3 stat3 NOUN jw827942h2c 11 28 affected affect VERB jw827942h2c 11 29 cone cone NOUN jw827942h2c 11 30 photoreceptor photoreceptor NOUN jw827942h2c 11 31 cell cell NOUN jw827942h2c 11 32 and and CCONJ jw827942h2c 11 33 m?ller m?ller VERB jw827942h2c 11 34 glial glial ADJ jw827942h2c 11 35 cell cell NOUN jw827942h2c 11 36 maintenance maintenance NOUN jw827942h2c 11 37 . . PUNCT jw827942h2c 12 1 these these DET jw827942h2c 12 2 results result NOUN jw827942h2c 12 3 indicated indicate VERB jw827942h2c 12 4 that that SCONJ jw827942h2c 12 5 jak jak ADV jw827942h2c 12 6 / / SYM jw827942h2c 12 7 stat3 stat3 NOUN jw827942h2c 12 8 signaling signaling NOUN jw827942h2c 12 9 is be AUX jw827942h2c 12 10 important important ADJ jw827942h2c 12 11 to to ADP jw827942h2c 12 12 the the DET jw827942h2c 12 13 development development NOUN jw827942h2c 12 14 of of ADP jw827942h2c 12 15 photoreceptor photoreceptor NOUN jw827942h2c 12 16 and and CCONJ jw827942h2c 12 17 m?ller m?ller X jw827942h2c 12 18 glial glial ADJ jw827942h2c 12 19 cells cell NOUN jw827942h2c 12 20 as as ADV jw827942h2c 12 21 well well ADV jw827942h2c 12 22 as as ADP jw827942h2c 12 23 the the DET jw827942h2c 12 24 maintenance maintenance NOUN jw827942h2c 12 25 of of ADP jw827942h2c 12 26 a a DET jw827942h2c 12 27 healthy healthy ADJ jw827942h2c 12 28 retina retina NOUN jw827942h2c 12 29 . . PUNCT jw827942h2c 13 1 the the DET jw827942h2c 13 2 adult adult NOUN jw827942h2c 13 3 zebrafish zebrafish NOUN jw827942h2c 13 4 retina retina NOUN jw827942h2c 13 5 regenerates regenerate VERB jw827942h2c 13 6 following follow VERB jw827942h2c 13 7 light light ADJ jw827942h2c 13 8 - - PUNCT jw827942h2c 13 9 induced induce VERB jw827942h2c 13 10 photoreceptor photoreceptor NOUN jw827942h2c 13 11 cell cell NOUN jw827942h2c 13 12 death death NOUN jw827942h2c 13 13 . . PUNCT jw827942h2c 14 1 m?ller m?ller X jw827942h2c 14 2 glial glial ADJ jw827942h2c 14 3 cells cell NOUN jw827942h2c 14 4 in in ADP jw827942h2c 14 5 light light ADV jw827942h2c 14 6 - - PUNCT jw827942h2c 14 7 damaged damage VERB jw827942h2c 14 8 retinas retina NOUN jw827942h2c 14 9 divide divide VERB jw827942h2c 14 10 yielding yield VERB jw827942h2c 14 11 undifferentiated undifferentiated ADJ jw827942h2c 14 12 progenitors progenitor NOUN jw827942h2c 14 13 that that PRON jw827942h2c 14 14 migrate migrate VERB jw827942h2c 14 15 and and CCONJ jw827942h2c 14 16 differentiate differentiate VERB jw827942h2c 14 17 to to PART jw827942h2c 14 18 replace replace VERB jw827942h2c 14 19 the the DET jw827942h2c 14 20 lost lose VERB jw827942h2c 14 21 rod rod NOUN jw827942h2c 14 22 and and CCONJ jw827942h2c 14 23 cone cone NOUN jw827942h2c 14 24 photoreceptors photoreceptor NOUN jw827942h2c 14 25 . . PUNCT jw827942h2c 15 1 we we PRON jw827942h2c 15 2 demonstrated demonstrate VERB jw827942h2c 15 3 previously previously ADV jw827942h2c 15 4 that that SCONJ jw827942h2c 15 5 , , PUNCT jw827942h2c 15 6 following follow VERB jw827942h2c 15 7 light light ADJ jw827942h2c 15 8 - - PUNCT jw827942h2c 15 9 induced induce VERB jw827942h2c 15 10 photoreceptor photoreceptor NOUN jw827942h2c 15 11 cell cell NOUN jw827942h2c 15 12 death death NOUN jw827942h2c 15 13 , , PUNCT jw827942h2c 15 14 a a DET jw827942h2c 15 15 loss loss NOUN jw827942h2c 15 16 of of ADP jw827942h2c 15 17 either either PRON jw827942h2c 15 18 tnfα tnfα ADJ jw827942h2c 15 19 ; ; PUNCT jw827942h2c 15 20 or or CCONJ jw827942h2c 15 21 stat3 stat3 NOUN jw827942h2c 15 22 reduced reduce VERB jw827942h2c 15 23 m?ller m?ller PUNCT jw827942h2c 15 24 glial glial ADJ jw827942h2c 15 25 cell cell NOUN jw827942h2c 15 26 proliferation proliferation NOUN jw827942h2c 15 27 significantly significantly ADV jw827942h2c 15 28 , , PUNCT jw827942h2c 15 29 suggesting suggest VERB jw827942h2c 15 30 that that SCONJ jw827942h2c 15 31 the the DET jw827942h2c 15 32 number number NOUN jw827942h2c 15 33 of of ADP jw827942h2c 15 34 m?ller m?ller SPACE jw827942h2c 15 35 glia glia NOUN jw827942h2c 15 36 that that PRON jw827942h2c 15 37 reenter reenter VERB jw827942h2c 15 38 the the DET jw827942h2c 15 39 cell cell NOUN jw827942h2c 15 40 cycle cycle NOUN jw827942h2c 15 41 following follow VERB jw827942h2c 15 42 retinal retinal ADJ jw827942h2c 15 43 damage damage NOUN jw827942h2c 15 44 was be AUX jw827942h2c 15 45 dependent dependent ADJ jw827942h2c 15 46 upon upon SCONJ jw827942h2c 15 47 coordinated coordinated ADJ jw827942h2c 15 48 expression expression NOUN jw827942h2c 15 49 of of ADP jw827942h2c 15 50 tnfα tnfα PROPN jw827942h2c 15 51 ; ; PUNCT jw827942h2c 15 52 and and CCONJ jw827942h2c 15 53 stat3 stat3 NOUN jw827942h2c 15 54 ( ( PUNCT jw827942h2c 15 55 nelson nelson PROPN jw827942h2c 15 56 et et PROPN jw827942h2c 15 57 al al PROPN jw827942h2c 15 58 . . PROPN jw827942h2c 15 59 , , PUNCT jw827942h2c 15 60 2013 2013 NUM jw827942h2c 15 61 ) ) PUNCT jw827942h2c 15 62 . . PUNCT jw827942h2c 16 1 although although SCONJ jw827942h2c 16 2 it it PRON jw827942h2c 16 3 seems seem VERB jw827942h2c 16 4 likely likely ADJ jw827942h2c 16 5 that that SCONJ jw827942h2c 16 6 tnfα tnfα ADP jw827942h2c 16 7 ; ; PUNCT jw827942h2c 16 8 initiates initiate VERB jw827942h2c 16 9 stat3 stat3 NOUN jw827942h2c 16 10 signaling signal VERB jw827942h2c 16 11 through through ADP jw827942h2c 16 12 a a DET jw827942h2c 16 13 cytokine cytokine NOUN jw827942h2c 16 14 - - PUNCT jw827942h2c 16 15 receptor receptor NOUN jw827942h2c 16 16 mediated mediate VERB jw827942h2c 16 17 pathway pathway NOUN jw827942h2c 16 18 , , PUNCT jw827942h2c 16 19 a a DET jw827942h2c 16 20 receptor receptor NOUN jw827942h2c 16 21 linking link VERB jw827942h2c 16 22 the the DET jw827942h2c 16 23 two two NUM jw827942h2c 16 24 proteins protein NOUN jw827942h2c 16 25 together together ADV jw827942h2c 16 26 has have VERB jw827942h2c 16 27 yet yet ADV jw827942h2c 16 28 to to PART jw827942h2c 16 29 be be AUX jw827942h2c 16 30 identified identify VERB jw827942h2c 16 31 . . PUNCT jw827942h2c 17 1 also also ADV jw827942h2c 17 2 , , PUNCT jw827942h2c 17 3 previous previous ADJ jw827942h2c 17 4 studies study NOUN jw827942h2c 17 5 demonstrated demonstrate VERB jw827942h2c 17 6 that that SCONJ jw827942h2c 17 7 tyrosine tyrosine NOUN jw827942h2c 17 8 phosphorylation phosphorylation NOUN jw827942h2c 17 9 of of ADP jw827942h2c 17 10 stat3 stat3 NOUN jw827942h2c 17 11 and and CCONJ jw827942h2c 17 12 downstream downstream ADJ jw827942h2c 17 13 activation activation NOUN jw827942h2c 17 14 of of ADP jw827942h2c 17 15 stat3 stat3 NOUN jw827942h2c 17 16 - - PUNCT jw827942h2c 17 17 activated activate VERB jw827942h2c 17 18 genes gene NOUN jw827942h2c 17 19 , , PUNCT jw827942h2c 17 20 including include VERB jw827942h2c 17 21 the the DET jw827942h2c 17 22 two two NUM jw827942h2c 17 23 zebrafish zebrafish NOUN jw827942h2c 17 24 paralogues paralogue NOUN jw827942h2c 17 25 of of ADP jw827942h2c 17 26 socs3 socs3 PROPN jw827942h2c 17 27 ( ( PUNCT jw827942h2c 17 28 socs3a socs3a PROPN jw827942h2c 17 29 and and CCONJ jw827942h2c 17 30 socs3b socs3b NOUN jw827942h2c 17 31 ) ) PUNCT jw827942h2c 17 32 , , PUNCT jw827942h2c 17 33 was be AUX jw827942h2c 17 34 associated associate VERB jw827942h2c 17 35 with with ADP jw827942h2c 17 36 neuronal neuronal ADJ jw827942h2c 17 37 regeneration regeneration NOUN jw827942h2c 17 38 ( ( PUNCT jw827942h2c 17 39 elsaeidi elsaeidi PROPN jw827942h2c 17 40 et et PROPN jw827942h2c 17 41 al al PROPN jw827942h2c 17 42 . . PROPN jw827942h2c 17 43 , , PUNCT jw827942h2c 17 44 2014 2014 NUM jw827942h2c 17 45 ; ; PUNCT jw827942h2c 17 46 liang liang PROPN jw827942h2c 17 47 et et PROPN jw827942h2c 17 48 al al PROPN jw827942h2c 17 49 . . PROPN jw827942h2c 17 50 , , PUNCT jw827942h2c 17 51 2012 2012 NUM jw827942h2c 17 52 ) ) PUNCT jw827942h2c 17 53 . . PUNCT jw827942h2c 18 1 however however ADV jw827942h2c 18 2 , , PUNCT jw827942h2c 18 3 the the DET jw827942h2c 18 4 kinase kinase NOUN jw827942h2c 18 5 responsible responsible ADJ jw827942h2c 18 6 for for ADP jw827942h2c 18 7 tyrosine tyrosine NOUN jw827942h2c 18 8 phosphorylation phosphorylation NOUN jw827942h2c 18 9 of of ADP jw827942h2c 18 10 stat3 stat3 NOUN jw827942h2c 18 11 and and CCONJ jw827942h2c 18 12 the the DET jw827942h2c 18 13 role role NOUN jw827942h2c 18 14 of of ADP jw827942h2c 18 15 socs3a socs3a PROPN jw827942h2c 18 16 and and CCONJ jw827942h2c 18 17 socs3b socs3b PRON jw827942h2c 18 18 in in ADP jw827942h2c 18 19 regulating regulate VERB jw827942h2c 18 20 m?ller m?ller PUNCT jw827942h2c 18 21 glial glial ADJ jw827942h2c 18 22 proliferation proliferation NOUN jw827942h2c 18 23 remains remain VERB jw827942h2c 18 24 elusive elusive ADJ jw827942h2c 18 25 . . PUNCT jw827942h2c 19 1 this this DET jw827942h2c 19 2 report report NOUN jw827942h2c 19 3 demonstrates demonstrate VERB jw827942h2c 19 4 that that SCONJ jw827942h2c 19 5 tnfα tnfα ADP jw827942h2c 19 6 ; ; PUNCT jw827942h2c 19 7 , , PUNCT jw827942h2c 19 8 stat3 stat3 NOUN jw827942h2c 19 9 , , PUNCT jw827942h2c 19 10 and and CCONJ jw827942h2c 19 11 socs3a socs3a PROPN jw827942h2c 19 12 associate associate VERB jw827942h2c 19 13 with with ADP jw827942h2c 19 14 tnfrsfa tnfrsfa NOUN jw827942h2c 19 15 ( ( PUNCT jw827942h2c 19 16 tumor tumor NOUN jw827942h2c 19 17 necrosis necrosis NOUN jw827942h2c 19 18 factor factor NOUN jw827942h2c 19 19 receptor receptor NOUN jw827942h2c 19 20 superfamily superfamily NOUN jw827942h2c 19 21 member member NOUN jw827942h2c 19 22 a a PRON jw827942h2c 19 23 ) ) PUNCT jw827942h2c 19 24 in in ADP jw827942h2c 19 25 the the DET jw827942h2c 19 26 regenerating regenerate VERB jw827942h2c 19 27 retina retina NOUN jw827942h2c 19 28 and and CCONJ jw827942h2c 19 29 that that SCONJ jw827942h2c 19 30 a a DET jw827942h2c 19 31 loss loss NOUN jw827942h2c 19 32 of of ADP jw827942h2c 19 33 tnfrsfa tnfrsfa NOUN jw827942h2c 19 34 decreases decrease VERB jw827942h2c 19 35 stat3 stat3 NOUN jw827942h2c 19 36 - - PUNCT jw827942h2c 19 37 mediated mediate VERB jw827942h2c 19 38 expression expression NOUN jw827942h2c 19 39 of of ADP jw827942h2c 19 40 socs3a socs3a PROPN jw827942h2c 19 41 and and CCONJ jw827942h2c 19 42 tnfα tnfα PROPN jw827942h2c 19 43 ; ; PUNCT jw827942h2c 19 44 , , PUNCT jw827942h2c 19 45 which which PRON jw827942h2c 19 46 causes cause VERB jw827942h2c 19 47 a a DET jw827942h2c 19 48 significant significant ADJ jw827942h2c 19 49 reduction reduction NOUN jw827942h2c 19 50 in in ADP jw827942h2c 19 51 m?ller m?ller SPACE jw827942h2c 19 52 glia glia NOUN jw827942h2c 19 53 proliferation proliferation NOUN jw827942h2c 19 54 similar similar ADJ jw827942h2c 19 55 to to ADP jw827942h2c 19 56 what what PRON jw827942h2c 19 57 is be AUX jw827942h2c 19 58 observed observe VERB jw827942h2c 19 59 when when SCONJ jw827942h2c 19 60 decreasing decrease VERB jw827942h2c 19 61 either either CCONJ jw827942h2c 19 62 tnfα tnfα ADJ jw827942h2c 19 63 ; ; PUNCT jw827942h2c 19 64 or or CCONJ jw827942h2c 19 65 stat3 stat3 NOUN jw827942h2c 19 66 expression expression NOUN jw827942h2c 19 67 alone alone ADV jw827942h2c 19 68 . . PUNCT jw827942h2c 20 1 this this DET jw827942h2c 20 2 work work NOUN jw827942h2c 20 3 also also ADV jw827942h2c 20 4 demonstrates demonstrate VERB jw827942h2c 20 5 that that SCONJ jw827942h2c 20 6 jak1 jak1 PROPN jw827942h2c 20 7 mediates mediate VERB jw827942h2c 20 8 m?ller m?ller X jw827942h2c 20 9 glial glial ADJ jw827942h2c 20 10 proliferation proliferation NOUN jw827942h2c 20 11 through through ADP jw827942h2c 20 12 y708 y708 PROPN jw827942h2c 20 13 phosphorylation phosphorylation NOUN jw827942h2c 20 14 of of ADP jw827942h2c 20 15 stat3 stat3 NOUN jw827942h2c 20 16 and and CCONJ jw827942h2c 20 17 that that SCONJ jw827942h2c 20 18 socs3a socs3a PROPN jw827942h2c 20 19 and and CCONJ jw827942h2c 20 20 socs3b socs3b NOUN jw827942h2c 20 21 are be AUX jw827942h2c 20 22 expressed express VERB jw827942h2c 20 23 in in ADP jw827942h2c 20 24 m?ller m?ller SPACE jw827942h2c 20 25 glia glia NOUN jw827942h2c 20 26 in in ADP jw827942h2c 20 27 the the DET jw827942h2c 20 28 adult adult NOUN jw827942h2c 20 29 light light ADJ jw827942h2c 20 30 - - PUNCT jw827942h2c 20 31 damaged damage VERB jw827942h2c 20 32 retina retina NOUN jw827942h2c 20 33 . . PUNCT jw827942h2c 21 1 a a DET jw827942h2c 21 2 knockdown knockdown NOUN jw827942h2c 21 3 of of ADP jw827942h2c 21 4 either either CCONJ jw827942h2c 21 5 socs3 socs3 ADJ jw827942h2c 21 6 gene gene NOUN jw827942h2c 21 7 alone alone ADV jw827942h2c 21 8 has have VERB jw827942h2c 21 9 no no DET jw827942h2c 21 10 effect effect NOUN jw827942h2c 21 11 on on ADP jw827942h2c 21 12 stat3 stat3 NOUN jw827942h2c 21 13 expression expression NOUN jw827942h2c 21 14 or or CCONJ jw827942h2c 21 15 m?ller m?ller PUNCT jw827942h2c 21 16 glial glial ADJ jw827942h2c 21 17 proliferation proliferation NOUN jw827942h2c 21 18 . . PUNCT jw827942h2c 22 1 however however ADV jw827942h2c 22 2 , , PUNCT jw827942h2c 22 3 a a DET jw827942h2c 22 4 knockdown knockdown NOUN jw827942h2c 22 5 of of ADP jw827942h2c 22 6 socs3a socs3a PROPN jw827942h2c 22 7 and and CCONJ jw827942h2c 22 8 socs3b socs3b DET jw827942h2c 22 9 combined combine VERB jw827942h2c 22 10 results result NOUN jw827942h2c 22 11 in in ADP jw827942h2c 22 12 a a DET jw827942h2c 22 13 significant significant ADJ jw827942h2c 22 14 increase increase NOUN jw827942h2c 22 15 in in ADP jw827942h2c 22 16 stat3 stat3 NOUN jw827942h2c 22 17 expression expression NOUN jw827942h2c 22 18 as as ADV jw827942h2c 22 19 well well ADV jw827942h2c 22 20 as as ADP jw827942h2c 22 21 m?ller m?ller X jw827942h2c 22 22 glial glial ADJ jw827942h2c 22 23 proliferation proliferation NOUN jw827942h2c 22 24 in in ADP jw827942h2c 22 25 response response NOUN jw827942h2c 22 26 to to ADP jw827942h2c 22 27 light light ADJ jw827942h2c 22 28 damage damage NOUN jw827942h2c 22 29 . . PUNCT jw827942h2c 23 1 taken take VERB jw827942h2c 23 2 together together ADV jw827942h2c 23 3 , , PUNCT jw827942h2c 23 4 these these DET jw827942h2c 23 5 studies study NOUN jw827942h2c 23 6 demonstrate demonstrate VERB jw827942h2c 23 7 that that SCONJ jw827942h2c 23 8 tnfα tnfα ADP jw827942h2c 23 9 ; ; PUNCT jw827942h2c 23 10 likely likely ADV jw827942h2c 23 11 induces induce VERB jw827942h2c 23 12 activation activation NOUN jw827942h2c 23 13 of of ADP jw827942h2c 23 14 stat3 stat3 NOUN jw827942h2c 23 15 through through ADP jw827942h2c 23 16 a a DET jw827942h2c 23 17 tnfrsfa tnfrsfa NOUN jw827942h2c 23 18 / / SYM jw827942h2c 23 19 jak1 jak1 PROPN jw827942h2c 23 20 signaling signal VERB jw827942h2c 23 21 cascade cascade NOUN jw827942h2c 23 22 and and CCONJ jw827942h2c 23 23 that that SCONJ jw827942h2c 23 24 socs3a socs3a PROPN jw827942h2c 23 25 and and CCONJ jw827942h2c 23 26 socs3b socs3b DET jw827942h2c 23 27 function function NOUN jw827942h2c 23 28 to to PART jw827942h2c 23 29 dampen dampen VERB jw827942h2c 23 30 the the DET jw827942h2c 23 31 proliferative proliferative ADJ jw827942h2c 23 32 response response NOUN jw827942h2c 23 33 of of ADP jw827942h2c 23 34 m?ller m?ller SPACE jw827942h2c 23 35 glia glia NOUN jw827942h2c 23 36 caused cause VERB jw827942h2c 23 37 by by ADP jw827942h2c 23 38 stat3 stat3 NOUN jw827942h2c 23 39 . . PUNCT