id sid tid token lemma pos jd472v26592 1 1 the the DET jd472v26592 1 2 aortic aortic NOUN jd472v26592 1 3 valve valve NOUN jd472v26592 1 4 is be AUX jd472v26592 1 5 located locate VERB jd472v26592 1 6 between between ADP jd472v26592 1 7 the the DET jd472v26592 1 8 left left ADJ jd472v26592 1 9 ventricle ventricle NOUN jd472v26592 1 10 and and CCONJ jd472v26592 1 11 the the DET jd472v26592 1 12 aorta aorta NOUN jd472v26592 1 13 and and CCONJ jd472v26592 1 14 ensures ensure VERB jd472v26592 1 15 unidirectional unidirectional ADJ jd472v26592 1 16 blood blood NOUN jd472v26592 1 17 flow flow NOUN jd472v26592 1 18 between between ADP jd472v26592 1 19 the the DET jd472v26592 1 20 left left ADJ jd472v26592 1 21 ventricle ventricle NOUN jd472v26592 1 22 and and CCONJ jd472v26592 1 23 the the DET jd472v26592 1 24 aorta aorta NOUN jd472v26592 1 25 by by ADP jd472v26592 1 26 opening open VERB jd472v26592 1 27 during during ADP jd472v26592 1 28 systole systole NOUN jd472v26592 1 29 ( ( PUNCT jd472v26592 1 30 ventricle ventricle NOUN jd472v26592 1 31 contraction contraction NOUN jd472v26592 1 32 ) ) PUNCT jd472v26592 1 33 and and CCONJ jd472v26592 1 34 closing close VERB jd472v26592 1 35 during during ADP jd472v26592 1 36 diastole diastole NOUN jd472v26592 1 37 ( ( PUNCT jd472v26592 1 38 ventricle ventricle NOUN jd472v26592 1 39 relaxation relaxation NOUN jd472v26592 1 40 ) ) PUNCT jd472v26592 1 41 . . PUNCT jd472v26592 2 1 the the DET jd472v26592 2 2 normal normal ADJ jd472v26592 2 3 valve valve NOUN jd472v26592 2 4 , , PUNCT jd472v26592 2 5 known know VERB jd472v26592 2 6 as as ADP jd472v26592 2 7 the the DET jd472v26592 2 8 tricuspid tricuspid NOUN jd472v26592 2 9 aortic aortic NOUN jd472v26592 2 10 valve valve NOUN jd472v26592 2 11 ( ( PUNCT jd472v26592 2 12 tav tav PROPN jd472v26592 2 13 ) ) PUNCT jd472v26592 2 14 consists consist VERB jd472v26592 2 15 of of ADP jd472v26592 2 16 three three NUM jd472v26592 2 17 leaflets leaflet NOUN jd472v26592 2 18 . . PUNCT jd472v26592 3 1 the the DET jd472v26592 3 2 bicuspid bicuspid NOUN jd472v26592 3 3 aortic aortic NOUN jd472v26592 3 4 valve valve NOUN jd472v26592 3 5 ( ( PUNCT jd472v26592 3 6 bav bav NOUN jd472v26592 3 7 ) ) PUNCT jd472v26592 3 8 is be AUX jd472v26592 3 9 the the DET jd472v26592 3 10 most most ADV jd472v26592 3 11 common common ADJ jd472v26592 3 12 congenital congenital ADJ jd472v26592 3 13 valvular valvular ADJ jd472v26592 3 14 defect defect NOUN jd472v26592 3 15 , , PUNCT jd472v26592 3 16 in in ADP jd472v26592 3 17 which which PRON jd472v26592 3 18 two two NUM jd472v26592 3 19 of of ADP jd472v26592 3 20 the the DET jd472v26592 3 21 three three NUM jd472v26592 3 22 leaflets leaflet NOUN jd472v26592 3 23 fuse fuse VERB jd472v26592 3 24 during during ADP jd472v26592 3 25 the the DET jd472v26592 3 26 development development NOUN jd472v26592 3 27 . . PUNCT jd472v26592 4 1 the the DET jd472v26592 4 2 most most ADV jd472v26592 4 3 prevalent prevalent ADJ jd472v26592 4 4 type type NOUN jd472v26592 4 5 - - PUNCT jd472v26592 4 6 i i PRON jd472v26592 4 7 morphology morphology NOUN jd472v26592 4 8 features feature VERB jd472v26592 4 9 two two NUM jd472v26592 4 10 cusps cusps NOUN jd472v26592 4 11 of of ADP jd472v26592 4 12 unequal unequal ADJ jd472v26592 4 13 size size NOUN jd472v26592 4 14 ( ( PUNCT jd472v26592 4 15 resulting result VERB jd472v26592 4 16 from from ADP jd472v26592 4 17 the the DET jd472v26592 4 18 fusion fusion NOUN jd472v26592 4 19 of of ADP jd472v26592 4 20 two two NUM jd472v26592 4 21 of of ADP jd472v26592 4 22 the the DET jd472v26592 4 23 three three NUM jd472v26592 4 24 leaflets leaflet NOUN jd472v26592 4 25 ) ) PUNCT jd472v26592 4 26 and and CCONJ jd472v26592 4 27 a a DET jd472v26592 4 28 fibrous fibrous ADJ jd472v26592 4 29 raphe raphe NOUN jd472v26592 4 30 at at ADP jd472v26592 4 31 the the DET jd472v26592 4 32 location location NOUN jd472v26592 4 33 of of ADP jd472v26592 4 34 congenital congenital ADJ jd472v26592 4 35 fusion fusion NOUN jd472v26592 4 36 . . PUNCT jd472v26592 5 1 while while SCONJ jd472v26592 5 2 71 71 NUM jd472v26592 5 3 % % NOUN jd472v26592 5 4 of of ADP jd472v26592 5 5 type type NOUN jd472v26592 5 6 - - PUNCT jd472v26592 5 7 i i PRON jd472v26592 5 8 bavs bavs VERB jd472v26592 5 9 result result NOUN jd472v26592 5 10 from from ADP jd472v26592 5 11 the the DET jd472v26592 5 12 fusion fusion NOUN jd472v26592 5 13 between between ADP jd472v26592 5 14 the the DET jd472v26592 5 15 rightand rightand ADJ jd472v26592 5 16 left left ADJ jd472v26592 5 17 - - PUNCT jd472v26592 5 18 coronary coronary ADJ jd472v26592 5 19 leaflets leaflet NOUN jd472v26592 5 20 ( ( PUNCT jd472v26592 5 21 lr lr PROPN jd472v26592 5 22 subtype subtype NOUN jd472v26592 5 23 ) ) PUNCT jd472v26592 5 24 , , PUNCT jd472v26592 5 25 15 15 NUM jd472v26592 5 26 % % NOUN jd472v26592 5 27 feature feature NOUN jd472v26592 5 28 rightand rightand ADJ jd472v26592 5 29 non non ADJ jd472v26592 5 30 - - ADJ jd472v26592 5 31 coronary coronary ADJ jd472v26592 5 32 cusp cusp PROPN jd472v26592 5 33 fusion fusion NOUN jd472v26592 5 34 ( ( PUNCT jd472v26592 5 35 rn rn PROPN jd472v26592 5 36 subtype subtype NOUN jd472v26592 5 37 ) ) PUNCT jd472v26592 5 38 and and CCONJ jd472v26592 5 39 3 3 NUM jd472v26592 5 40 % % NOUN jd472v26592 5 41 present present ADJ jd472v26592 5 42 with with ADP jd472v26592 5 43 nonand nonand PROPN jd472v26592 5 44 left left ADJ jd472v26592 5 45 - - PUNCT jd472v26592 5 46 coronary coronary ADJ jd472v26592 5 47 cusp cusp PROPN jd472v26592 5 48 fusion fusion NOUN jd472v26592 5 49 ( ( PUNCT jd472v26592 5 50 nl nl PROPN jd472v26592 5 51 subtype subtype NOUN jd472v26592 5 52 ) ) PUNCT jd472v26592 5 53 . . PUNCT jd472v26592 6 1 while while SCONJ jd472v26592 6 2 the the DET jd472v26592 6 3 bav bav NOUN jd472v26592 6 4 morphology morphology NOUN jd472v26592 6 5 may may AUX jd472v26592 6 6 not not PART jd472v26592 6 7 intrinsically intrinsically ADV jd472v26592 6 8 hamper hamper VERB jd472v26592 6 9 valvular valvular ADJ jd472v26592 6 10 function function NOUN jd472v26592 6 11 , , PUNCT jd472v26592 6 12 it it PRON jd472v26592 6 13 is be AUX jd472v26592 6 14 associated associate VERB jd472v26592 6 15 with with ADP jd472v26592 6 16 a a DET jd472v26592 6 17 spectrum spectrum NOUN jd472v26592 6 18 of of ADP jd472v26592 6 19 secondary secondary ADJ jd472v26592 6 20 valvulopathy valvulopathy ADJ jd472v26592 6 21 and and CCONJ jd472v26592 6 22 aortopathy aortopathy PROPN jd472v26592 6 23 such such ADJ jd472v26592 6 24 as as ADP jd472v26592 6 25 calcific calcific PROPN jd472v26592 6 26 aortic aortic NOUN jd472v26592 6 27 valve valve NOUN jd472v26592 6 28 disease disease NOUN jd472v26592 6 29 ( ( PUNCT jd472v26592 6 30 cavd cavd NOUN jd472v26592 6 31 ) ) PUNCT jd472v26592 6 32 and and CCONJ jd472v26592 6 33 aortic aortic NOUN jd472v26592 6 34 dilation dilation NOUN jd472v26592 6 35 . . PUNCT jd472v26592 7 1 in in ADP jd472v26592 7 2 addition addition NOUN jd472v26592 7 3 , , PUNCT jd472v26592 7 4 the the DET jd472v26592 7 5 particular particular ADJ jd472v26592 7 6 leaflet leaflet NOUN jd472v26592 7 7 fusion fusion NOUN jd472v26592 7 8 type type NOUN jd472v26592 7 9 affects affect VERB jd472v26592 7 10 the the DET jd472v26592 7 11 expression expression NOUN jd472v26592 7 12 of of ADP jd472v26592 7 13 dilation dilation NOUN jd472v26592 7 14 and and CCONJ jd472v26592 7 15 thinning thinning NOUN jd472v26592 7 16 of of ADP jd472v26592 7 17 the the DET jd472v26592 7 18 ascending ascend VERB jd472v26592 7 19 aorta aorta PROPN jd472v26592 7 20 ( ( PUNCT jd472v26592 7 21 aa aa PROPN jd472v26592 7 22 ) ) PUNCT jd472v26592 7 23 downstream downstream NOUN jd472v26592 7 24 of of ADP jd472v26592 7 25 a a DET jd472v26592 7 26 bav bav NOUN jd472v26592 7 27 . . PUNCT jd472v26592 8 1 while while SCONJ jd472v26592 8 2 the the DET jd472v26592 8 3 lr lr PROPN jd472v26592 8 4 cusp cusp PROPN jd472v26592 8 5 fusion fusion NOUN jd472v26592 8 6 is be AUX jd472v26592 8 7 primarily primarily ADV jd472v26592 8 8 associated associate VERB jd472v26592 8 9 with with ADP jd472v26592 8 10 dilation dilation NOUN jd472v26592 8 11 of of ADP jd472v26592 8 12 the the DET jd472v26592 8 13 aortic aortic NOUN jd472v26592 8 14 root root NOUN jd472v26592 8 15 and and CCONJ jd472v26592 8 16 the the DET jd472v26592 8 17 aa aa PROPN jd472v26592 8 18 convexity convexity PROPN jd472v26592 8 19 , , PUNCT jd472v26592 8 20 dilation dilation NOUN jd472v26592 8 21 patterns pattern VERB jd472v26592 8 22 downstream downstream ADV jd472v26592 8 23 of of ADP jd472v26592 8 24 rn rn NOUN jd472v26592 8 25 - - NOUN jd472v26592 8 26 bavs bavs NOUN jd472v26592 8 27 localize localize NOUN jd472v26592 8 28 to to ADP jd472v26592 8 29 the the DET jd472v26592 8 30 tubular tubular ADJ jd472v26592 8 31 aa aa NOUN jd472v26592 8 32 and and CCONJ jd472v26592 8 33 sometimes sometimes ADV jd472v26592 8 34 extend extend VERB jd472v26592 8 35 to to ADP jd472v26592 8 36 the the DET jd472v26592 8 37 transverse transverse NOUN jd472v26592 8 38 aortic aortic NOUN jd472v26592 8 39 arch arch NOUN jd472v26592 8 40 . . PUNCT jd472v26592 9 1 while while SCONJ jd472v26592 9 2 these these DET jd472v26592 9 3 bav bav NOUN jd472v26592 9 4 complications complication NOUN jd472v26592 9 5 have have AUX jd472v26592 9 6 been be AUX jd472v26592 9 7 historically historically ADV jd472v26592 9 8 linked link VERB jd472v26592 9 9 to to ADP jd472v26592 9 10 the the DET jd472v26592 9 11 same same ADJ jd472v26592 9 12 genetic genetic ADJ jd472v26592 9 13 defect defect NOUN jd472v26592 9 14 responsible responsible ADJ jd472v26592 9 15 for for ADP jd472v26592 9 16 the the DET jd472v26592 9 17 bav bav NOUN jd472v26592 9 18 morphogenesis morphogenesis NOUN jd472v26592 9 19 , , PUNCT jd472v26592 9 20 recent recent ADJ jd472v26592 9 21 in in ADP jd472v26592 9 22 vivo vivo PROPN jd472v26592 9 23 , , PUNCT jd472v26592 9 24 in in ADP jd472v26592 9 25 vitro vitro X jd472v26592 9 26 and and CCONJ jd472v26592 9 27 computational computational ADJ jd472v26592 9 28 studies study NOUN jd472v26592 9 29 have have AUX jd472v26592 9 30 revealed reveal VERB jd472v26592 9 31 the the DET jd472v26592 9 32 existence existence NOUN jd472v26592 9 33 of of ADP jd472v26592 9 34 abnormal abnormal ADJ jd472v26592 9 35 hemodynamics hemodynamic NOUN jd472v26592 9 36 in in ADP jd472v26592 9 37 the the DET jd472v26592 9 38 bav bav NOUN jd472v26592 9 39 , , PUNCT jd472v26592 9 40 which which PRON jd472v26592 9 41 may may AUX jd472v26592 9 42 contribute contribute VERB jd472v26592 9 43 to to ADP jd472v26592 9 44 the the DET jd472v26592 9 45 early early ADJ jd472v26592 9 46 and and CCONJ jd472v26592 9 47 rapid rapid ADJ jd472v26592 9 48 development development NOUN jd472v26592 9 49 of of ADP jd472v26592 9 50 cavd cavd NOUN jd472v26592 9 51 and and CCONJ jd472v26592 9 52 aortic aortic NOUN jd472v26592 9 53 dilation dilation NOUN jd472v26592 9 54 in in ADP jd472v26592 9 55 bav bav NOUN jd472v26592 9 56 patients patient NOUN jd472v26592 9 57 . . PUNCT jd472v26592 10 1 however however ADV jd472v26592 10 2 , , PUNCT jd472v26592 10 3 the the DET jd472v26592 10 4 native native ADJ jd472v26592 10 5 fluid fluid ADJ jd472v26592 10 6 wall wall NOUN jd472v26592 10 7 shear shear ADJ jd472v26592 10 8 stress stress NOUN jd472v26592 10 9 ( ( PUNCT jd472v26592 10 10 wss wss ADJ jd472v26592 10 11 ) ) PUNCT jd472v26592 10 12 environment environment NOUN jd472v26592 10 13 in in ADP jd472v26592 10 14 the the DET jd472v26592 10 15 bav bav NOUN jd472v26592 10 16 and and CCONJ jd472v26592 10 17 bav bav NOUN jd472v26592 10 18 aa aa PROPN jd472v26592 10 19 remain remain VERB jd472v26592 10 20 largely largely ADV jd472v26592 10 21 unknown unknown ADJ jd472v26592 10 22 , , PUNCT jd472v26592 10 23 which which PRON jd472v26592 10 24 hinders hinder VERB jd472v26592 10 25 the the DET jd472v26592 10 26 assessment assessment NOUN jd472v26592 10 27 of of ADP jd472v26592 10 28 this this DET jd472v26592 10 29 hemodynamic hemodynamic ADJ jd472v26592 10 30 theory theory NOUN jd472v26592 10 31 . . PUNCT jd472v26592 11 1 therefore therefore ADV jd472v26592 11 2 , , PUNCT jd472v26592 11 3 the the DET jd472v26592 11 4 objective objective NOUN jd472v26592 11 5 of of ADP jd472v26592 11 6 this this DET jd472v26592 11 7 dissertation dissertation NOUN jd472v26592 11 8 was be AUX jd472v26592 11 9 to to PART jd472v26592 11 10 computationally computationally ADV jd472v26592 11 11 quantify quantify VERB jd472v26592 11 12 the the DET jd472v26592 11 13 native native ADJ jd472v26592 11 14 mechanical mechanical ADJ jd472v26592 11 15 environment environment NOUN jd472v26592 11 16 on on ADP jd472v26592 11 17 bav bav NOUN jd472v26592 11 18 leaflets leaflet NOUN jd472v26592 11 19 and and CCONJ jd472v26592 11 20 bav bav NOUN jd472v26592 11 21 aortas aorta NOUN jd472v26592 11 22 using use VERB jd472v26592 11 23 fluid fluid NOUN jd472v26592 11 24 - - PUNCT jd472v26592 11 25 structure structure NOUN jd472v26592 11 26 interaction interaction NOUN jd472v26592 11 27 ( ( PUNCT jd472v26592 11 28 fsi fsi ADV jd472v26592 11 29 ) ) PUNCT jd472v26592 11 30 modeling.in modeling.in NUM jd472v26592 11 31 specific specific ADJ jd472v26592 11 32 aim aim NOUN jd472v26592 11 33 1 1 NUM jd472v26592 11 34 , , PUNCT jd472v26592 11 35 arbitrary arbitrary ADJ jd472v26592 11 36 lagrangian lagrangian ADJ jd472v26592 11 37 eulerian eulerian NOUN jd472v26592 11 38 ( ( PUNCT jd472v26592 11 39 ale ale NOUN jd472v26592 11 40 ) ) PUNCT jd472v26592 12 1 fsi fsi NOUN jd472v26592 12 2 models model NOUN jd472v26592 12 3 were be AUX jd472v26592 12 4 designed design VERB jd472v26592 12 5 to to PART jd472v26592 12 6 simulate simulate VERB jd472v26592 12 7 the the DET jd472v26592 12 8 flow flow NOUN jd472v26592 12 9 and and CCONJ jd472v26592 12 10 leaflet leaflet NOUN jd472v26592 12 11 dynamics dynamic NOUN jd472v26592 12 12 in in ADP jd472v26592 12 13 idealized idealized PROPN jd472v26592 12 14 tav tav PROPN jd472v26592 12 15 , , PUNCT jd472v26592 12 16 type-0 type-0 PROPN jd472v26592 12 17 and and CCONJ jd472v26592 12 18 type type NOUN jd472v26592 12 19 - - PUNCT jd472v26592 12 20 i i NOUN jd472v26592 12 21 bav bav NOUN jd472v26592 12 22 geometries geometry NOUN jd472v26592 12 23 subjected subject VERB jd472v26592 12 24 to to ADP jd472v26592 12 25 physiologic physiologic ADJ jd472v26592 12 26 transvalvular transvalvular ADJ jd472v26592 12 27 pressure pressure NOUN jd472v26592 12 28 . . PUNCT jd472v26592 13 1 the the DET jd472v26592 13 2 regional regional ADJ jd472v26592 13 3 leaflet leaflet NOUN jd472v26592 13 4 mechanics mechanic NOUN jd472v26592 13 5 was be AUX jd472v26592 13 6 quantified quantify VERB jd472v26592 13 7 in in ADP jd472v26592 13 8 terms term NOUN jd472v26592 13 9 of of ADP jd472v26592 13 10 temporal temporal ADJ jd472v26592 13 11 shear shear ADJ jd472v26592 13 12 magnitude magnitude NOUN jd472v26592 13 13 ( ( PUNCT jd472v26592 13 14 tsm tsm PROPN jd472v26592 13 15 ) ) PUNCT jd472v26592 13 16 , , PUNCT jd472v26592 13 17 oscillatory oscillatory ADJ jd472v26592 13 18 shear shear ADJ jd472v26592 13 19 index index NOUN jd472v26592 13 20 ( ( PUNCT jd472v26592 13 21 osi osi PROPN jd472v26592 13 22 ) ) PUNCT jd472v26592 13 23 , , PUNCT jd472v26592 13 24 temporal temporal ADJ jd472v26592 13 25 shear shear ADJ jd472v26592 13 26 gradient gradient NOUN jd472v26592 13 27 ( ( PUNCT jd472v26592 13 28 tsg tsg NOUN jd472v26592 13 29 ) ) PUNCT jd472v26592 13 30 and and CCONJ jd472v26592 13 31 stretch stretch NOUN jd472v26592 13 32 . . PUNCT jd472v26592 14 1 the the DET jd472v26592 14 2 simulations simulation NOUN jd472v26592 14 3 identified identify VERB jd472v26592 14 4 regions region NOUN jd472v26592 14 5 of of ADP jd472v26592 14 6 wss wss ADJ jd472v26592 14 7 overloads overload NOUN jd472v26592 14 8 and and CCONJ jd472v26592 14 9 increased increase VERB jd472v26592 14 10 wss wss ADJ jd472v26592 14 11 oscillations oscillation NOUN jd472v26592 14 12 in in ADP jd472v26592 14 13 bav bav NOUN jd472v26592 14 14 leaflets leaflet NOUN jd472v26592 14 15 relative relative ADJ jd472v26592 14 16 to to ADP jd472v26592 14 17 tav tav NOUN jd472v26592 14 18 leaflets leaflet NOUN jd472v26592 14 19 . . PUNCT jd472v26592 15 1 bav bav NOUN jd472v26592 15 2 leaflets leaflet NOUN jd472v26592 15 3 also also ADV jd472v26592 15 4 experienced experience VERB jd472v26592 15 5 larger large ADJ jd472v26592 15 6 radial radial ADJ jd472v26592 15 7 deformations deformation NOUN jd472v26592 15 8 than than ADP jd472v26592 15 9 tav tav PROPN jd472v26592 15 10 leaflets leaflet NOUN jd472v26592 15 11 . . PUNCT jd472v26592 16 1 type type NOUN jd472v26592 16 2 - - PUNCT jd472v26592 16 3 i i NOUN jd472v26592 16 4 bav bav NOUN jd472v26592 16 5 leaflets leaflet NOUN jd472v26592 16 6 exhibited exhibit VERB jd472v26592 16 7 contrasted contrast VERB jd472v26592 16 8 wss wss ADJ jd472v26592 16 9 environments environment NOUN jd472v26592 16 10 marked mark VERB jd472v26592 16 11 by by ADP jd472v26592 16 12 wss wss ADJ jd472v26592 16 13 overloads overload NOUN jd472v26592 16 14 on on ADP jd472v26592 16 15 the the DET jd472v26592 16 16 non non ADJ jd472v26592 16 17 - - ADJ jd472v26592 16 18 coronary coronary ADJ jd472v26592 16 19 leaflet leaflet NOUN jd472v26592 16 20 and and CCONJ jd472v26592 16 21 sub sub ADJ jd472v26592 16 22 - - ADJ jd472v26592 16 23 physiologic physiologic ADJ jd472v26592 16 24 wss wss ADJ jd472v26592 16 25 levels level NOUN jd472v26592 16 26 on on ADP jd472v26592 16 27 the the DET jd472v26592 16 28 fused fused ADJ jd472v26592 16 29 leaflet leaflet NOUN jd472v26592 16 30 . . PUNCT jd472v26592 17 1 this this DET jd472v26592 17 2 study study NOUN jd472v26592 17 3 demonstrated demonstrate VERB jd472v26592 17 4 the the DET jd472v26592 17 5 existence existence NOUN jd472v26592 17 6 of of ADP jd472v26592 17 7 abnormal abnormal ADJ jd472v26592 17 8 wss wss NOUN jd472v26592 17 9 on on ADP jd472v26592 17 10 bav bav NOUN jd472v26592 17 11 leaflets leaflet NOUN jd472v26592 17 12 , , PUNCT jd472v26592 17 13 which which PRON jd472v26592 17 14 may may AUX jd472v26592 17 15 further further VERB jd472v26592 17 16 our our PRON jd472v26592 17 17 understanding understanding NOUN jd472v26592 17 18 of of ADP jd472v26592 17 19 the the DET jd472v26592 17 20 role role NOUN jd472v26592 17 21 played play VERB jd472v26592 17 22 by by ADP jd472v26592 17 23 hemodynamic hemodynamic ADJ jd472v26592 17 24 forces force NOUN jd472v26592 17 25 in in ADP jd472v26592 17 26 bav bav NOUN jd472v26592 17 27 disease disease NOUN jd472v26592 17 28 . . PUNCT jd472v26592 18 1 in in ADP jd472v26592 18 2 specific specific ADJ jd472v26592 18 3 aim aim NOUN jd472v26592 18 4 2 2 NUM jd472v26592 18 5 , , PUNCT jd472v26592 18 6 an an DET jd472v26592 18 7 fsi fsi ADJ jd472v26592 18 8 model model NOUN jd472v26592 18 9 of of ADP jd472v26592 18 10 the the DET jd472v26592 18 11 tav tav PROPN jd472v26592 18 12 with with ADP jd472v26592 18 13 coronary coronary ADJ jd472v26592 18 14 arteries artery NOUN jd472v26592 18 15 was be AUX jd472v26592 18 16 developed develop VERB jd472v26592 18 17 to to PART jd472v26592 18 18 quantify quantify VERB jd472v26592 18 19 the the DET jd472v26592 18 20 effect effect NOUN jd472v26592 18 21 of of ADP jd472v26592 18 22 coronary coronary ADJ jd472v26592 18 23 flow flow NOUN jd472v26592 18 24 on on ADP jd472v26592 18 25 leaflet leaflet PROPN jd472v26592 18 26 wss wss ADJ jd472v26592 18 27 and and CCONJ jd472v26592 18 28 assess assess VERB jd472v26592 18 29 the the DET jd472v26592 18 30 assumption assumption NOUN jd472v26592 18 31 of of ADP jd472v26592 18 32 neglecting neglect VERB jd472v26592 18 33 coronary coronary ADJ jd472v26592 18 34 arteries artery NOUN jd472v26592 18 35 in in ADP jd472v26592 18 36 specific specific ADJ jd472v26592 18 37 aim aim NOUN jd472v26592 18 38 1 1 NUM jd472v26592 18 39 . . PUNCT jd472v26592 19 1 the the DET jd472v26592 19 2 study study NOUN jd472v26592 19 3 demonstrated demonstrate VERB jd472v26592 19 4 that that SCONJ jd472v26592 19 5 coronary coronary ADJ jd472v26592 19 6 flow flow NOUN jd472v26592 19 7 increased increase VERB jd472v26592 19 8 wss wss ADJ jd472v26592 19 9 magnitude magnitude NOUN jd472v26592 19 10 and and CCONJ jd472v26592 19 11 decreased decrease VERB jd472v26592 19 12 wss wss ADJ jd472v26592 19 13 oscillations oscillation NOUN jd472v26592 19 14 on on ADP jd472v26592 19 15 the the DET jd472v26592 19 16 tip tip NOUN jd472v26592 19 17 and and CCONJ jd472v26592 19 18 belly belly NOUN jd472v26592 19 19 regions region NOUN jd472v26592 19 20 of of ADP jd472v26592 19 21 the the DET jd472v26592 19 22 leaflet leaflet NOUN jd472v26592 19 23 while while SCONJ jd472v26592 19 24 the the DET jd472v26592 19 25 presence presence NOUN jd472v26592 19 26 of of ADP jd472v26592 19 27 coronary coronary ADJ jd472v26592 19 28 arteries artery NOUN jd472v26592 19 29 had have AUX jd472v26592 19 30 limited limit VERB jd472v26592 19 31 effect effect NOUN jd472v26592 19 32 on on ADP jd472v26592 19 33 the the DET jd472v26592 19 34 base base NOUN jd472v26592 19 35 of of ADP jd472v26592 19 36 the the DET jd472v26592 19 37 leaflet leaflet PROPN jd472v26592 19 38 fibrosa fibrosa NOUN jd472v26592 19 39 ( ( PUNCT jd472v26592 19 40 i.e. i.e. X jd472v26592 19 41 region region NOUN jd472v26592 19 42 most most ADV jd472v26592 19 43 prone prone ADJ jd472v26592 19 44 to to ADP jd472v26592 19 45 calcification calcification NOUN jd472v26592 19 46 ) ) PUNCT jd472v26592 19 47 . . PUNCT jd472v26592 20 1 this this DET jd472v26592 20 2 study study NOUN jd472v26592 20 3 provided provide VERB jd472v26592 20 4 important important ADJ jd472v26592 20 5 insight insight NOUN jd472v26592 20 6 into into ADP jd472v26592 20 7 the the DET jd472v26592 20 8 effect effect NOUN jd472v26592 20 9 of of ADP jd472v26592 20 10 coronary coronary ADJ jd472v26592 20 11 flow flow NOUN jd472v26592 20 12 on on ADP jd472v26592 20 13 leaflet leaflet PROPN jd472v26592 20 14 wss wss ADJ jd472v26592 20 15 and and CCONJ jd472v26592 20 16 justified justify VERB jd472v26592 20 17 the the DET jd472v26592 20 18 assumption assumption NOUN jd472v26592 20 19 of of ADP jd472v26592 20 20 neglecting neglect VERB jd472v26592 20 21 coronary coronary ADJ jd472v26592 20 22 arteries artery NOUN jd472v26592 20 23 in in ADP jd472v26592 20 24 specific specific ADJ jd472v26592 20 25 aim1 aim1 NOUN jd472v26592 20 26 to to PART jd472v26592 20 27 predict predict VERB jd472v26592 20 28 wss wss ADJ jd472v26592 20 29 on on ADP jd472v26592 20 30 leaflet leaflet ADJ jd472v26592 20 31 regions region NOUN jd472v26592 20 32 most most ADV jd472v26592 20 33 prone prone ADJ jd472v26592 20 34 to to PART jd472v26592 20 35 calcification.in calcification.in SYM jd472v26592 20 36 specific specific ADJ jd472v26592 20 37 aim aim NOUN jd472v26592 20 38 3 3 NUM jd472v26592 20 39 , , PUNCT jd472v26592 20 40 3d 3d NUM jd472v26592 20 41 fsi fsi ADJ jd472v26592 20 42 models model NOUN jd472v26592 20 43 of of ADP jd472v26592 20 44 unified unify VERB jd472v26592 20 45 valve valve NOUN jd472v26592 20 46 - - PUNCT jd472v26592 20 47 aorta aorta NOUN jd472v26592 20 48 geometries geometry NOUN jd472v26592 20 49 were be AUX jd472v26592 20 50 designed design VERB jd472v26592 20 51 to to PART jd472v26592 20 52 quantify quantify VERB jd472v26592 20 53 hemodynamics hemodynamic NOUN jd472v26592 20 54 and and CCONJ jd472v26592 20 55 regional regional ADJ jd472v26592 20 56 wss wss NOUN jd472v26592 20 57 in in ADP jd472v26592 20 58 a a DET jd472v26592 20 59 non non ADJ jd472v26592 20 60 - - ADJ jd472v26592 20 61 dilated dilated ADJ jd472v26592 20 62 aa aa NOUN jd472v26592 20 63 subjected subject VERB jd472v26592 20 64 to to ADP jd472v26592 20 65 tav tav PROPN jd472v26592 20 66 and and CCONJ jd472v26592 20 67 three three NUM jd472v26592 20 68 type type NOUN jd472v26592 20 69 - - PUNCT jd472v26592 20 70 i i NOUN jd472v26592 20 71 bav bav NOUN jd472v26592 20 72 morphotypes morphotype NOUN jd472v26592 20 73 ( ( PUNCT jd472v26592 20 74 lr lr PROPN jd472v26592 20 75 , , PUNCT jd472v26592 20 76 rn rn PROPN jd472v26592 20 77 and and CCONJ jd472v26592 20 78 nl nl PROPN jd472v26592 20 79 ) ) PUNCT jd472v26592 20 80 flows flow VERB jd472v26592 20 81 . . PUNCT jd472v26592 21 1 this this DET jd472v26592 21 2 study study NOUN jd472v26592 21 3 revealed reveal VERB jd472v26592 21 4 that that SCONJ jd472v26592 21 5 bavs bavs PROPN jd472v26592 21 6 generated generate VERB jd472v26592 21 7 eccentric eccentric ADJ jd472v26592 21 8 and and CCONJ jd472v26592 21 9 helical helical ADJ jd472v26592 21 10 flow flow NOUN jd472v26592 21 11 in in ADP jd472v26592 21 12 the the DET jd472v26592 21 13 aa aa NOUN jd472v26592 21 14 while while SCONJ jd472v26592 21 15 flow flow NOUN jd472v26592 21 16 was be AUX jd472v26592 21 17 essentially essentially ADV jd472v26592 21 18 axisymmetric axisymmetric ADJ jd472v26592 21 19 in in ADP jd472v26592 21 20 the the DET jd472v26592 21 21 tav tav PROPN jd472v26592 21 22 aa aa PROPN jd472v26592 21 23 . . PUNCT jd472v26592 21 24 bavs bavs PROPN jd472v26592 21 25 also also ADV jd472v26592 21 26 generated generate VERB jd472v26592 21 27 morphotype morphotype ADJ jd472v26592 21 28 - - PUNCT jd472v26592 21 29 dependent dependent ADJ jd472v26592 21 30 wss wss ADJ jd472v26592 21 31 abnormalities abnormality NOUN jd472v26592 21 32 in in ADP jd472v26592 21 33 terms term NOUN jd472v26592 21 34 of of ADP jd472v26592 21 35 magnitude magnitude NOUN jd472v26592 21 36 and and CCONJ jd472v26592 21 37 directionality directionality NOUN jd472v26592 21 38 on on ADP jd472v26592 21 39 the the DET jd472v26592 21 40 ascending ascend VERB jd472v26592 21 41 aortic aortic PROPN jd472v26592 21 42 wall wall NOUN jd472v26592 21 43 . . PUNCT jd472v26592 22 1 the the DET jd472v26592 22 2 lr lr PROPN jd472v26592 22 3 - - PUNCT jd472v26592 22 4 bav bav NOUN jd472v26592 22 5 and and CCONJ jd472v26592 22 6 nl nl NOUN jd472v26592 22 7 - - NOUN jd472v26592 22 8 bav bav NOUN jd472v26592 22 9 generated generate VERB jd472v26592 22 10 wss wss ADJ jd472v26592 22 11 overloads overload NOUN jd472v26592 22 12 on on ADP jd472v26592 22 13 the the DET jd472v26592 22 14 proximal proximal ADJ jd472v26592 22 15 aa aa NOUN jd472v26592 22 16 while while SCONJ jd472v26592 22 17 the the DET jd472v26592 22 18 proximal proximal ADJ jd472v26592 22 19 segment segment NOUN jd472v26592 22 20 of of ADP jd472v26592 22 21 the the DET jd472v26592 22 22 rn rn NOUN jd472v26592 22 23 - - NOUN jd472v26592 22 24 bav bav NOUN jd472v26592 22 25 aa aa NOUN jd472v26592 22 26 was be AUX jd472v26592 22 27 subjected subject VERB jd472v26592 22 28 to to ADP jd472v26592 22 29 similar similar ADJ jd472v26592 22 30 wss wss NOUN jd472v26592 22 31 to to ADP jd472v26592 22 32 the the DET jd472v26592 22 33 tav tav PROPN jd472v26592 22 34 aa aa PROPN jd472v26592 22 35 . . PUNCT jd472v26592 23 1 in in ADP jd472v26592 23 2 addition addition NOUN jd472v26592 23 3 , , PUNCT jd472v26592 23 4 all all DET jd472v26592 23 5 bav bav NOUN jd472v26592 23 6 models model NOUN jd472v26592 23 7 generated generate VERB jd472v26592 23 8 abnormal abnormal ADJ jd472v26592 23 9 unidirectional unidirectional NOUN jd472v26592 23 10 wss wss ADJ jd472v26592 23 11 on on ADP jd472v26592 23 12 the the DET jd472v26592 23 13 proximal proximal ADJ jd472v26592 23 14 segments segment NOUN jd472v26592 23 15 as as SCONJ jd472v26592 23 16 compared compare VERB jd472v26592 23 17 to to ADP jd472v26592 23 18 the the DET jd472v26592 23 19 tav tav PROPN jd472v26592 23 20 . . PUNCT jd472v26592 24 1 while while SCONJ jd472v26592 24 2 the the DET jd472v26592 24 3 middle middle PROPN jd472v26592 24 4 aas aas PROPN jd472v26592 24 5 of of ADP jd472v26592 24 6 the the DET jd472v26592 24 7 tav tav PROPN jd472v26592 24 8 and and CCONJ jd472v26592 24 9 the the DET jd472v26592 24 10 lr lr NOUN jd472v26592 24 11 - - PUNCT jd472v26592 24 12 bav bav PROPN jd472v26592 24 13 were be AUX jd472v26592 24 14 subjected subject VERB jd472v26592 24 15 to to ADP jd472v26592 24 16 bidirectional bidirectional ADJ jd472v26592 24 17 wss wss NOUN jd472v26592 24 18 , , PUNCT jd472v26592 24 19 wss wss ADJ jd472v26592 24 20 on on ADP jd472v26592 24 21 the the DET jd472v26592 24 22 rn rn NOUN jd472v26592 24 23 - - NOUN jd472v26592 24 24 bav bav NOUN jd472v26592 24 25 and and CCONJ jd472v26592 24 26 the the DET jd472v26592 24 27 nl nl PROPN jd472v26592 24 28 - - NOUN jd472v26592 24 29 bav bav PROPN jd472v26592 24 30 aas aas NOUN jd472v26592 24 31 remained remain VERB jd472v26592 24 32 unidirectional unidirectional ADJ jd472v26592 24 33 on on ADP jd472v26592 24 34 the the DET jd472v26592 24 35 middle middle ADJ jd472v26592 24 36 segments segment NOUN jd472v26592 24 37 . . PUNCT jd472v26592 25 1 the the DET jd472v26592 25 2 results result NOUN jd472v26592 25 3 reported report VERB jd472v26592 25 4 in in ADP jd472v26592 25 5 this this DET jd472v26592 25 6 study study NOUN jd472v26592 25 7 indicated indicate VERB jd472v26592 25 8 the the DET jd472v26592 25 9 existence existence NOUN jd472v26592 25 10 of of ADP jd472v26592 25 11 strong strong ADJ jd472v26592 25 12 hemodynamic hemodynamic ADJ jd472v26592 25 13 abnormalities abnormality NOUN jd472v26592 25 14 in in ADP jd472v26592 25 15 type type NOUN jd472v26592 25 16 - - PUNCT jd472v26592 25 17 i i PRON jd472v26592 25 18 bav bav PROPN jd472v26592 25 19 aas aas PROPN jd472v26592 25 20 , , PUNCT jd472v26592 25 21 their their PRON jd472v26592 25 22 dependence dependence NOUN jd472v26592 25 23 on on ADP jd472v26592 25 24 bav bav NOUN jd472v26592 25 25 morphotype morphotype NOUN jd472v26592 25 26 and and CCONJ jd472v26592 25 27 their their PRON jd472v26592 25 28 colocalization colocalization NOUN jd472v26592 25 29 with with ADP jd472v26592 25 30 sites site NOUN jd472v26592 25 31 vulnerable vulnerable ADJ jd472v26592 25 32 to to ADP jd472v26592 25 33 dilation.in dilation.in NUM jd472v26592 25 34 conclusion conclusion NOUN jd472v26592 25 35 , , PUNCT jd472v26592 25 36 this this DET jd472v26592 25 37 dissertation dissertation NOUN jd472v26592 25 38 aimed aim VERB jd472v26592 25 39 at at ADP jd472v26592 25 40 characterizing characterize VERB jd472v26592 25 41 the the DET jd472v26592 25 42 key key ADJ jd472v26592 25 43 mechanical mechanical ADJ jd472v26592 25 44 differences difference NOUN jd472v26592 25 45 between between ADP jd472v26592 25 46 tav tav PROPN jd472v26592 25 47 and and CCONJ jd472v26592 25 48 bav bav NOUN jd472v26592 25 49 leaflets leaflet NOUN jd472v26592 25 50 and and CCONJ jd472v26592 25 51 aortas aorta NOUN jd472v26592 25 52 . . PUNCT jd472v26592 26 1 the the DET jd472v26592 26 2 models model NOUN jd472v26592 26 3 demonstrated demonstrate VERB jd472v26592 26 4 the the DET jd472v26592 26 5 existence existence NOUN jd472v26592 26 6 of of ADP jd472v26592 26 7 abnormal abnormal ADJ jd472v26592 26 8 mechanical mechanical ADJ jd472v26592 26 9 environment environment NOUN jd472v26592 26 10 in in ADP jd472v26592 26 11 bavs bavs PROPN jd472v26592 26 12 and and CCONJ jd472v26592 26 13 downstream downstream ADJ jd472v26592 26 14 aas aas NOUN jd472v26592 26 15 relative relative ADJ jd472v26592 26 16 to to ADP jd472v26592 26 17 the the DET jd472v26592 26 18 tav tav PROPN jd472v26592 26 19 . . PUNCT jd472v26592 27 1 the the DET jd472v26592 27 2 results result NOUN jd472v26592 27 3 provided provide VERB jd472v26592 27 4 important important ADJ jd472v26592 27 5 insights insight NOUN jd472v26592 27 6 into into ADP jd472v26592 27 7 the the DET jd472v26592 27 8 mechanical mechanical ADJ jd472v26592 27 9 characteristics characteristic NOUN jd472v26592 27 10 of of ADP jd472v26592 27 11 bav bav NOUN jd472v26592 27 12 leaflets leaflet NOUN jd472v26592 27 13 and and CCONJ jd472v26592 27 14 aas aas NOUN jd472v26592 27 15 , , PUNCT jd472v26592 27 16 which which PRON jd472v26592 27 17 may may AUX jd472v26592 27 18 further further VERB jd472v26592 27 19 our our PRON jd472v26592 27 20 understanding understanding NOUN jd472v26592 27 21 of of ADP jd472v26592 27 22 the the DET jd472v26592 27 23 role role NOUN jd472v26592 27 24 played play VERB jd472v26592 27 25 by by ADP jd472v26592 27 26 hemodynamic hemodynamic ADJ jd472v26592 27 27 forces force NOUN jd472v26592 27 28 in in ADP jd472v26592 27 29 bav bav NOUN jd472v26592 27 30 disease disease NOUN jd472v26592 27 31 . . PUNCT