id	sid	tid	token	lemma	pos
j6731260m8g	1	1	tuberculosis	tuberculosis	NOUN
j6731260m8g	1	2	(	(	PUNCT
j6731260m8g	1	3	tb	tb	PROPN
j6731260m8g	1	4	)	)	PUNCT
j6731260m8g	1	5	remains	remain	VERB
j6731260m8g	1	6	a	a	DET
j6731260m8g	1	7	formidable	formidable	ADJ
j6731260m8g	1	8	global	global	ADJ
j6731260m8g	1	9	health	health	NOUN
j6731260m8g	1	10	threat	threat	NOUN
j6731260m8g	1	11	,	,	PUNCT
j6731260m8g	1	12	with	with	ADP
j6731260m8g	1	13	10	10	NUM
j6731260m8g	1	14	million	million	NUM
j6731260m8g	1	15	new	new	ADJ
j6731260m8g	1	16	cases	case	NOUN
j6731260m8g	1	17	and	and	CCONJ
j6731260m8g	1	18	1.5	1.5	NUM
j6731260m8g	1	19	million	million	NUM
j6731260m8g	1	20	deaths	death	NOUN
j6731260m8g	1	21	reported	report	VERB
j6731260m8g	1	22	in	in	ADP
j6731260m8g	1	23	2018	2018	NUM
j6731260m8g	1	24	alone	alone	ADV
j6731260m8g	1	25	.	.	PUNCT
j6731260m8g	2	1	tb	tb	PROPN
j6731260m8g	2	2	disease	disease	PROPN
j6731260m8g	2	3	is	be	AUX
j6731260m8g	2	4	caused	cause	VERB
j6731260m8g	2	5	by	by	ADP
j6731260m8g	2	6	the	the	DET
j6731260m8g	2	7	bacteria	bacteria	NOUN
j6731260m8g	2	8	mycobacterium	mycobacterium	NOUN
j6731260m8g	2	9	tuberculosis	tuberculosis	NOUN
j6731260m8g	2	10	(	(	PUNCT
j6731260m8g	2	11	m.	m.	NOUN
j6731260m8g	2	12	tuberculosis	tuberculosis	NOUN
j6731260m8g	2	13	)	)	PUNCT
j6731260m8g	2	14	.	.	PUNCT
j6731260m8g	3	1	additionally	additionally	ADV
j6731260m8g	3	2	,	,	PUNCT
j6731260m8g	3	3	infections	infection	NOUN
j6731260m8g	3	4	with	with	ADP
j6731260m8g	3	5	non	non	ADJ
j6731260m8g	3	6	-	-	ADJ
j6731260m8g	3	7	tuberculous	tuberculous	ADJ
j6731260m8g	3	8	mycobacteria	mycobacteria	NOUN
j6731260m8g	3	9	(	(	PUNCT
j6731260m8g	3	10	ntm	ntm	X
j6731260m8g	3	11	)	)	PUNCT
j6731260m8g	3	12	are	be	AUX
j6731260m8g	3	13	rapidly	rapidly	ADV
j6731260m8g	3	14	becoming	become	VERB
j6731260m8g	3	15	a	a	DET
j6731260m8g	3	16	public	public	ADJ
j6731260m8g	3	17	health	health	NOUN
j6731260m8g	3	18	threat	threat	NOUN
j6731260m8g	3	19	,	,	PUNCT
j6731260m8g	3	20	especially	especially	ADV
j6731260m8g	3	21	to	to	ADP
j6731260m8g	3	22	those	those	PRON
j6731260m8g	3	23	who	who	PRON
j6731260m8g	3	24	are	be	AUX
j6731260m8g	3	25	immunocompromised	immunocompromise	VERB
j6731260m8g	3	26	.	.	PUNCT
j6731260m8g	4	1	during	during	ADP
j6731260m8g	4	2	infection	infection	NOUN
j6731260m8g	4	3	,	,	PUNCT
j6731260m8g	4	4	pathogenic	pathogenic	ADJ
j6731260m8g	4	5	mycobacteria	mycobacterium	NOUN
j6731260m8g	4	6	are	be	AUX
j6731260m8g	4	7	taken	take	VERB
j6731260m8g	4	8	into	into	ADP
j6731260m8g	4	9	the	the	DET
j6731260m8g	4	10	phagosome	phagosome	ADJ
j6731260m8g	4	11	by	by	ADP
j6731260m8g	4	12	host	host	NOUN
j6731260m8g	4	13	macrophages	macrophage	NOUN
j6731260m8g	4	14	.	.	PUNCT
j6731260m8g	5	1	they	they	PRON
j6731260m8g	5	2	use	use	VERB
j6731260m8g	5	3	the	the	DET
j6731260m8g	5	4	esx-1	esx-1	X
j6731260m8g	5	5	secretion	secretion	NOUN
j6731260m8g	5	6	system	system	NOUN
j6731260m8g	5	7	to	to	PART
j6731260m8g	5	8	permeabilize	permeabilize	VERB
j6731260m8g	5	9	the	the	DET
j6731260m8g	5	10	phagosomal	phagosomal	ADJ
j6731260m8g	5	11	membrane	membrane	NOUN
j6731260m8g	5	12	,	,	PUNCT
j6731260m8g	5	13	and	and	CCONJ
j6731260m8g	5	14	evade	evade	VERB
j6731260m8g	5	15	death	death	NOUN
j6731260m8g	5	16	by	by	ADP
j6731260m8g	5	17	fusion	fusion	NOUN
j6731260m8g	5	18	with	with	ADP
j6731260m8g	5	19	the	the	DET
j6731260m8g	5	20	lysosome	lysosome	NOUN
j6731260m8g	5	21	.	.	PUNCT
j6731260m8g	6	1	this	this	DET
j6731260m8g	6	2	critical	critical	ADJ
j6731260m8g	6	3	step	step	NOUN
j6731260m8g	6	4	in	in	ADP
j6731260m8g	6	5	virulence	virulence	NOUN
j6731260m8g	6	6	is	be	AUX
j6731260m8g	6	7	highly	highly	ADV
j6731260m8g	6	8	conserved	conserve	VERB
j6731260m8g	6	9	between	between	ADP
j6731260m8g	6	10	m.	m.	NOUN
j6731260m8g	6	11	tuberculosis	tuberculosis	NOUN
j6731260m8g	6	12	and	and	CCONJ
j6731260m8g	6	13	the	the	DET
j6731260m8g	6	14	ntm	ntm	PROPN
j6731260m8g	6	15	pathogen	pathogen	PROPN
j6731260m8g	6	16	m.	m.	PROPN
j6731260m8g	6	17	marinum	marinum	PROPN
j6731260m8g	6	18	,	,	PUNCT
j6731260m8g	6	19	which	which	PRON
j6731260m8g	6	20	has	have	AUX
j6731260m8g	6	21	been	be	AUX
j6731260m8g	6	22	used	use	VERB
j6731260m8g	6	23	for	for	ADP
j6731260m8g	6	24	decades	decade	NOUN
j6731260m8g	6	25	as	as	ADP
j6731260m8g	6	26	a	a	DET
j6731260m8g	6	27	model	model	NOUN
j6731260m8g	6	28	system	system	NOUN
j6731260m8g	6	29	to	to	PART
j6731260m8g	6	30	study	study	VERB
j6731260m8g	6	31	esx-1	esx-1	ADP
j6731260m8g	6	32	secretion	secretion	NOUN
j6731260m8g	6	33	and	and	CCONJ
j6731260m8g	6	34	virulence	virulence	NOUN
j6731260m8g	6	35	.	.	PUNCT
j6731260m8g	7	1	the	the	DET
j6731260m8g	7	2	esx-1	esx-1	ADP
j6731260m8g	7	3	secretion	secretion	NOUN
j6731260m8g	7	4	system	system	NOUN
j6731260m8g	7	5	consists	consist	VERB
j6731260m8g	7	6	of	of	ADP
j6731260m8g	7	7	a	a	DET
j6731260m8g	7	8	core	core	ADJ
j6731260m8g	7	9	membrane	membrane	NOUN
j6731260m8g	7	10	complex	complex	NOUN
j6731260m8g	7	11	,	,	PUNCT
j6731260m8g	7	12	which	which	PRON
j6731260m8g	7	13	resides	reside	VERB
j6731260m8g	7	14	in	in	ADP
j6731260m8g	7	15	the	the	DET
j6731260m8g	7	16	cytoplasmic	cytoplasmic	ADJ
j6731260m8g	7	17	membrane	membrane	NOUN
j6731260m8g	7	18	of	of	ADP
j6731260m8g	7	19	the	the	DET
j6731260m8g	7	20	mycobacteria	mycobacteria	NOUN
j6731260m8g	7	21	.	.	PUNCT
j6731260m8g	8	1	it	it	PRON
j6731260m8g	8	2	is	be	AUX
j6731260m8g	8	3	responsible	responsible	ADJ
j6731260m8g	8	4	for	for	ADP
j6731260m8g	8	5	transporting	transport	VERB
j6731260m8g	8	6	small	small	ADJ
j6731260m8g	8	7	esx-1	esx-1	NOUN
j6731260m8g	8	8	protein	protein	NOUN
j6731260m8g	8	9	substrates	substrate	NOUN
j6731260m8g	8	10	from	from	ADP
j6731260m8g	8	11	the	the	DET
j6731260m8g	8	12	inside	inside	NOUN
j6731260m8g	8	13	of	of	ADP
j6731260m8g	8	14	the	the	DET
j6731260m8g	8	15	mycobacterial	mycobacterial	ADJ
j6731260m8g	8	16	cell	cell	NOUN
j6731260m8g	8	17	,	,	PUNCT
j6731260m8g	8	18	across	across	ADP
j6731260m8g	8	19	the	the	DET
j6731260m8g	8	20	cytoplasmic	cytoplasmic	ADJ
j6731260m8g	8	21	membrane	membrane	NOUN
j6731260m8g	8	22	,	,	PUNCT
j6731260m8g	8	23	to	to	ADP
j6731260m8g	8	24	the	the	DET
j6731260m8g	8	25	exterior	exterior	NOUN
j6731260m8g	8	26	of	of	ADP
j6731260m8g	8	27	the	the	DET
j6731260m8g	8	28	cell	cell	NOUN
j6731260m8g	8	29	.	.	PUNCT
j6731260m8g	9	1	this	this	DET
j6731260m8g	9	2	process	process	NOUN
j6731260m8g	9	3	is	be	AUX
j6731260m8g	9	4	both	both	PRON
j6731260m8g	9	5	exceedingly	exceedingly	ADV
j6731260m8g	9	6	important	important	ADJ
j6731260m8g	9	7	and	and	CCONJ
j6731260m8g	9	8	tightly	tightly	ADV
j6731260m8g	9	9	regulated	regulate	VERB
j6731260m8g	9	10	.	.	PUNCT
j6731260m8g	10	1	the	the	DET
j6731260m8g	10	2	survival	survival	NOUN
j6731260m8g	10	3	of	of	ADP
j6731260m8g	10	4	the	the	DET
j6731260m8g	10	5	pathogenic	pathogenic	ADJ
j6731260m8g	10	6	mycobacteria	mycobacteria	NOUN
j6731260m8g	10	7	relies	rely	VERB
j6731260m8g	10	8	upon	upon	SCONJ
j6731260m8g	10	9	secretion	secretion	NOUN
j6731260m8g	10	10	of	of	ADP
j6731260m8g	10	11	the	the	DET
j6731260m8g	10	12	correct	correct	ADJ
j6731260m8g	10	13	substrates	substrate	NOUN
j6731260m8g	10	14	,	,	PUNCT
j6731260m8g	10	15	in	in	ADP
j6731260m8g	10	16	the	the	DET
j6731260m8g	10	17	appropriate	appropriate	ADJ
j6731260m8g	10	18	amounts	amount	NOUN
j6731260m8g	10	19	at	at	ADP
j6731260m8g	10	20	exactly	exactly	ADV
j6731260m8g	10	21	the	the	DET
j6731260m8g	10	22	right	right	ADJ
j6731260m8g	10	23	time	time	NOUN
j6731260m8g	10	24	.	.	PUNCT
j6731260m8g	11	1	to	to	PART
j6731260m8g	11	2	do	do	VERB
j6731260m8g	11	3	this	this	PRON
j6731260m8g	11	4	,	,	PUNCT
j6731260m8g	11	5	the	the	DET
j6731260m8g	11	6	bacteria	bacteria	NOUN
j6731260m8g	11	7	must	must	AUX
j6731260m8g	11	8	connect	connect	VERB
j6731260m8g	11	9	membrane	membrane	NOUN
j6731260m8g	11	10	complex	complex	ADJ
j6731260m8g	11	11	assembly	assembly	NOUN
j6731260m8g	11	12	with	with	ADP
j6731260m8g	11	13	gene	gene	NOUN
j6731260m8g	11	14	transcription	transcription	NOUN
j6731260m8g	11	15	,	,	PUNCT
j6731260m8g	11	16	and	and	CCONJ
j6731260m8g	11	17	substrate	substrate	NOUN
j6731260m8g	11	18	secretion	secretion	NOUN
j6731260m8g	11	19	.	.	PUNCT
j6731260m8g	12	1	whib6	whib6	PROPN
j6731260m8g	12	2	is	be	AUX
j6731260m8g	12	3	a	a	DET
j6731260m8g	12	4	transcription	transcription	NOUN
j6731260m8g	12	5	factor	factor	NOUN
j6731260m8g	12	6	which	which	PRON
j6731260m8g	12	7	activates	activate	VERB
j6731260m8g	12	8	expression	expression	NOUN
j6731260m8g	12	9	of	of	ADP
j6731260m8g	12	10	esx-1	esx-1	PUNCT
j6731260m8g	12	11	substrate	substrate	NOUN
j6731260m8g	12	12	genes	gene	NOUN
j6731260m8g	12	13	.	.	PUNCT
j6731260m8g	13	1	we	we	PRON
j6731260m8g	13	2	found	find	VERB
j6731260m8g	13	3	that	that	SCONJ
j6731260m8g	13	4	the	the	DET
j6731260m8g	13	5	whib6	whib6	PROPN
j6731260m8g	13	6	transcription	transcription	NOUN
j6731260m8g	13	7	factor	factor	NOUN
j6731260m8g	13	8	responds	respond	VERB
j6731260m8g	13	9	to	to	ADP
j6731260m8g	13	10	the	the	DET
j6731260m8g	13	11	assembly	assembly	NOUN
j6731260m8g	13	12	of	of	ADP
j6731260m8g	13	13	the	the	DET
j6731260m8g	13	14	core	core	NOUN
j6731260m8g	13	15	esx-1	esx-1	X
j6731260m8g	13	16	complex	complex	NOUN
j6731260m8g	13	17	at	at	ADP
j6731260m8g	13	18	the	the	DET
j6731260m8g	13	19	cytoplasmic	cytoplasmic	ADJ
j6731260m8g	13	20	membrane	membrane	NOUN
j6731260m8g	13	21	,	,	PUNCT
j6731260m8g	13	22	a	a	DET
j6731260m8g	13	23	critical	critical	ADJ
j6731260m8g	13	24	checkpoint	checkpoint	NOUN
j6731260m8g	13	25	.	.	PUNCT
j6731260m8g	14	1	additionally	additionally	ADV
j6731260m8g	14	2	,	,	PUNCT
j6731260m8g	14	3	a	a	DET
j6731260m8g	14	4	transcription	transcription	NOUN
j6731260m8g	14	5	factor	factor	NOUN
j6731260m8g	14	6	,	,	PUNCT
j6731260m8g	14	7	espm	espm	PROPN
j6731260m8g	14	8	,	,	PUNCT
j6731260m8g	14	9	binds	bind	VERB
j6731260m8g	14	10	the	the	DET
j6731260m8g	14	11	promoter	promoter	NOUN
j6731260m8g	14	12	of	of	ADP
j6731260m8g	14	13	the	the	DET
j6731260m8g	14	14	whib6	whib6	PROPN
j6731260m8g	14	15	gene	gene	NOUN
j6731260m8g	14	16	,	,	PUNCT
j6731260m8g	14	17	and	and	CCONJ
j6731260m8g	14	18	is	be	AUX
j6731260m8g	14	19	required	require	VERB
j6731260m8g	14	20	for	for	ADP
j6731260m8g	14	21	repression	repression	NOUN
j6731260m8g	14	22	of	of	ADP
j6731260m8g	14	23	whib6	whib6	PROPN
j6731260m8g	14	24	gene	gene	NOUN
j6731260m8g	14	25	transcription	transcription	NOUN
j6731260m8g	14	26	in	in	ADP
j6731260m8g	14	27	the	the	DET
j6731260m8g	14	28	absence	absence	NOUN
j6731260m8g	14	29	of	of	ADP
j6731260m8g	14	30	the	the	DET
j6731260m8g	14	31	core	core	ADJ
j6731260m8g	14	32	membrane	membrane	NOUN
j6731260m8g	14	33	complex	complex	NOUN
j6731260m8g	14	34	.	.	PUNCT
j6731260m8g	15	1	this	this	PRON
j6731260m8g	15	2	effectively	effectively	ADV
j6731260m8g	15	3	connects	connect	VERB
j6731260m8g	15	4	the	the	DET
j6731260m8g	15	5	assembly	assembly	NOUN
j6731260m8g	15	6	of	of	ADP
j6731260m8g	15	7	the	the	DET
j6731260m8g	15	8	core	core	ADJ
j6731260m8g	15	9	membrane	membrane	NOUN
j6731260m8g	15	10	complex	complex	NOUN
j6731260m8g	15	11	to	to	ADP
j6731260m8g	15	12	gene	gene	NOUN
j6731260m8g	15	13	expression	expression	NOUN
j6731260m8g	15	14	in	in	ADP
j6731260m8g	15	15	m.	m.	PROPN
j6731260m8g	15	16	marinum	marinum	PROPN
j6731260m8g	15	17	.	.	PUNCT
j6731260m8g	16	1	further	far	ADV
j6731260m8g	16	2	,	,	PUNCT
j6731260m8g	16	3	we	we	PRON
j6731260m8g	16	4	discovered	discover	VERB
j6731260m8g	16	5	that	that	SCONJ
j6731260m8g	16	6	espe	espe	VERB
j6731260m8g	16	7	and	and	CCONJ
j6731260m8g	16	8	espf	espf	PROPN
j6731260m8g	16	9	,	,	PUNCT
j6731260m8g	16	10	known	know	VERB
j6731260m8g	16	11	esx-1	esx-1	ADP
j6731260m8g	16	12	secreted	secrete	VERB
j6731260m8g	16	13	substrates	substrate	NOUN
j6731260m8g	16	14	,	,	PUNCT
j6731260m8g	16	15	negatively	negatively	ADV
j6731260m8g	16	16	regulate	regulate	VERB
j6731260m8g	16	17	whib6	whib6	PROPN
j6731260m8g	16	18	gene	gene	NOUN
j6731260m8g	16	19	expression	expression	NOUN
j6731260m8g	16	20	.	.	PUNCT
j6731260m8g	17	1	they	they	PRON
j6731260m8g	17	2	are	be	AUX
j6731260m8g	17	3	also	also	ADV
j6731260m8g	17	4	required	require	VERB
j6731260m8g	17	5	for	for	ADP
j6731260m8g	17	6	virulence	virulence	NOUN
j6731260m8g	17	7	in	in	ADP
j6731260m8g	17	8	m.	m.	NOUN
j6731260m8g	17	9	marinum	marinum	PROPN
j6731260m8g	17	10	and	and	CCONJ
j6731260m8g	17	11	m.	m.	NOUN
j6731260m8g	17	12	tuberculosis	tuberculosis	NOUN
j6731260m8g	17	13	,	,	PUNCT
j6731260m8g	17	14	effectively	effectively	ADV
j6731260m8g	17	15	connecting	connect	VERB
j6731260m8g	17	16	esx-1	esx-1	ADP
j6731260m8g	17	17	secretion	secretion	NOUN
j6731260m8g	17	18	and	and	CCONJ
j6731260m8g	17	19	virulence	virulence	NOUN
j6731260m8g	17	20	with	with	ADP
j6731260m8g	17	21	gene	gene	NOUN
j6731260m8g	17	22	expression	expression	NOUN
j6731260m8g	17	23	and	and	CCONJ
j6731260m8g	17	24	fine	fine	ADV
j6731260m8g	17	25	-	-	PUNCT
j6731260m8g	17	26	tuning	tuning	NOUN
j6731260m8g	17	27	of	of	ADP
j6731260m8g	17	28	esx-1	esx-1	PUNCT
j6731260m8g	17	29	substrate	substrate	NOUN
j6731260m8g	17	30	production	production	NOUN
j6731260m8g	17	31	.	.	PUNCT