id sid tid token lemma pos j3860576808 1 1 leishmania leishmania PROPN j3860576808 1 2 is be AUX j3860576808 1 3 a a DET j3860576808 1 4 genus genus NOUN j3860576808 1 5 of of ADP j3860576808 1 6 intracellular intracellular ADJ j3860576808 1 7 parasites parasite NOUN j3860576808 1 8 that that PRON j3860576808 1 9 are be AUX j3860576808 1 10 responsible responsible ADJ j3860576808 1 11 for for ADP j3860576808 1 12 causing cause VERB j3860576808 1 13 the the DET j3860576808 1 14 disease disease NOUN j3860576808 1 15 leishmaniasis leishmaniasis NOUN j3860576808 1 16 . . PUNCT j3860576808 2 1 leishmaniasis leishmaniasis NOUN j3860576808 2 2 is be AUX j3860576808 2 3 a a DET j3860576808 2 4 complex complex NOUN j3860576808 2 5 of of ADP j3860576808 2 6 diseases disease NOUN j3860576808 2 7 ranging range VERB j3860576808 2 8 from from ADP j3860576808 2 9 self self NOUN j3860576808 2 10 - - PUNCT j3860576808 2 11 healing heal VERB j3860576808 2 12 cutaneous cutaneous ADJ j3860576808 2 13 lesions lesion NOUN j3860576808 2 14 to to ADP j3860576808 2 15 fatal fatal ADJ j3860576808 2 16 visceral visceral NOUN j3860576808 2 17 disease disease NOUN j3860576808 2 18 . . PUNCT j3860576808 3 1 leishmania leishmania PROPN j3860576808 3 2 major major PROPN j3860576808 3 3 is be AUX j3860576808 3 4 one one NUM j3860576808 3 5 of of ADP j3860576808 3 6 several several ADJ j3860576808 3 7 species specie NOUN j3860576808 3 8 which which PRON j3860576808 3 9 causes cause VERB j3860576808 3 10 cutaneous cutaneous ADJ j3860576808 3 11 leishmaniasis leishmaniasis NOUN j3860576808 3 12 and and CCONJ j3860576808 3 13 is be AUX j3860576808 3 14 frequently frequently ADV j3860576808 3 15 used use VERB j3860576808 3 16 in in ADP j3860576808 3 17 immunological immunological ADJ j3860576808 3 18 research research NOUN j3860576808 3 19 due due ADP j3860576808 3 20 to to ADP j3860576808 3 21 the the DET j3860576808 3 22 requirement requirement NOUN j3860576808 3 23 for for ADP j3860576808 3 24 a a DET j3860576808 3 25 t t NOUN j3860576808 3 26 helper helper NOUN j3860576808 3 27 1 1 NUM j3860576808 3 28 ( ( PUNCT j3860576808 3 29 th-1 th-1 SPACE j3860576808 3 30 ) ) PUNCT j3860576808 3 31 mediated mediate VERB j3860576808 3 32 response response NOUN j3860576808 3 33 in in ADP j3860576808 3 34 order order NOUN j3860576808 3 35 for for ADP j3860576808 3 36 healing healing NOUN j3860576808 3 37 and and CCONJ j3860576808 3 38 immunity immunity NOUN j3860576808 3 39 to to PART j3860576808 3 40 occur occur VERB j3860576808 3 41 . . PUNCT j3860576808 4 1 vitamin vitamin NOUN j3860576808 4 2 d d NOUN j3860576808 4 3 has have AUX j3860576808 4 4 been be AUX j3860576808 4 5 shown show VERB j3860576808 4 6 to to PART j3860576808 4 7 reduce reduce VERB j3860576808 4 8 or or CCONJ j3860576808 4 9 eliminate eliminate VERB j3860576808 4 10 many many ADJ j3860576808 4 11 symptoms symptom NOUN j3860576808 4 12 of of ADP j3860576808 4 13 t t PROPN j3860576808 4 14 cell cell NOUN j3860576808 4 15 mediated mediate VERB j3860576808 4 16 autoimmune autoimmune ADJ j3860576808 4 17 diseases disease NOUN j3860576808 4 18 in in ADP j3860576808 4 19 experimental experimental ADJ j3860576808 4 20 mouse mouse NOUN j3860576808 4 21 models model NOUN j3860576808 4 22 of of ADP j3860576808 4 23 diseases disease NOUN j3860576808 4 24 such such ADJ j3860576808 4 25 as as ADP j3860576808 4 26 multiple multiple ADJ j3860576808 4 27 sclerosis sclerosis NOUN j3860576808 4 28 , , PUNCT j3860576808 4 29 inflammatory inflammatory ADJ j3860576808 4 30 bowel bowel NOUN j3860576808 4 31 disorder disorder NOUN j3860576808 4 32 , , PUNCT j3860576808 4 33 and and CCONJ j3860576808 4 34 rheumatoid rheumatoid ADJ j3860576808 4 35 arthritis arthritis NOUN j3860576808 4 36 . . PUNCT j3860576808 5 1 these these DET j3860576808 5 2 diseases disease NOUN j3860576808 5 3 arise arise VERB j3860576808 5 4 due due ADP j3860576808 5 5 to to ADP j3860576808 5 6 an an DET j3860576808 5 7 inappropriate inappropriate ADJ j3860576808 5 8 th-1 th-1 DET j3860576808 5 9 response response NOUN j3860576808 5 10 to to ADP j3860576808 5 11 self self NOUN j3860576808 5 12 antigens antigen NOUN j3860576808 5 13 . . PUNCT j3860576808 6 1 the the DET j3860576808 6 2 active active ADJ j3860576808 6 3 metabolite metabolite NOUN j3860576808 6 4 of of ADP j3860576808 6 5 1,25d3 1,25d3 NUM j3860576808 6 6 exerts exert NOUN j3860576808 6 7 these these DET j3860576808 6 8 actions action NOUN j3860576808 6 9 via via ADP j3860576808 6 10 interaction interaction NOUN j3860576808 6 11 with with ADP j3860576808 6 12 the the DET j3860576808 6 13 vitamin vitamin NOUN j3860576808 6 14 d d NOUN j3860576808 6 15 receptor receptor NOUN j3860576808 6 16 ( ( PUNCT j3860576808 6 17 vdr vdr NOUN j3860576808 6 18 ) ) PUNCT j3860576808 6 19 . . PUNCT j3860576808 7 1 these these DET j3860576808 7 2 studies study NOUN j3860576808 7 3 aimed aim VERB j3860576808 7 4 to to PART j3860576808 7 5 investigate investigate VERB j3860576808 7 6 if if SCONJ j3860576808 7 7 ablation ablation NOUN j3860576808 7 8 of of ADP j3860576808 7 9 the the DET j3860576808 7 10 vitamin vitamin NOUN j3860576808 7 11 d d NOUN j3860576808 7 12 receptor receptor NOUN j3860576808 7 13 or or CCONJ j3860576808 7 14 vitamin vitamin NOUN j3860576808 7 15 d d NOUN j3860576808 7 16 deficiency deficiency NOUN j3860576808 7 17 plays play VERB j3860576808 7 18 a a DET j3860576808 7 19 role role NOUN j3860576808 7 20 in in ADP j3860576808 7 21 influencing influence VERB j3860576808 7 22 th-1 th-1 PUNCT j3860576808 7 23 and and CCONJ j3860576808 7 24 th-2 th-2 NOUN j3860576808 7 25 cytokine cytokine NOUN j3860576808 7 26 balance balance NOUN j3860576808 7 27 . . PUNCT j3860576808 8 1 we we PRON j3860576808 8 2 observed observe VERB j3860576808 8 3 that that SCONJ j3860576808 8 4 vdr vdr NOUN j3860576808 8 5 knockout knockout NOUN j3860576808 8 6 ( ( PUNCT j3860576808 8 7 ko ko PROPN j3860576808 8 8 ) ) PUNCT j3860576808 8 9 mice mouse NOUN j3860576808 8 10 develop develop VERB j3860576808 8 11 smaller small ADJ j3860576808 8 12 lesions lesion NOUN j3860576808 8 13 in in ADP j3860576808 8 14 response response NOUN j3860576808 8 15 to to ADP j3860576808 8 16 l. l. PROPN j3860576808 8 17 major major ADJ j3860576808 8 18 infection infection NOUN j3860576808 8 19 than than ADP j3860576808 8 20 their their PRON j3860576808 8 21 wild wild ADJ j3860576808 8 22 type type NOUN j3860576808 8 23 ( ( PUNCT j3860576808 8 24 wt wt PROPN j3860576808 8 25 ) ) PUNCT j3860576808 8 26 counterparts counterpart NOUN j3860576808 8 27 . . PUNCT j3860576808 9 1 additionally additionally ADV j3860576808 9 2 , , PUNCT j3860576808 9 3 vdr vdr NOUN j3860576808 9 4 ko ko PROPN j3860576808 9 5 mice mouse NOUN j3860576808 9 6 exhibit exhibit VERB j3860576808 9 7 a a DET j3860576808 9 8 decreased decreased ADJ j3860576808 9 9 parasite parasite NOUN j3860576808 9 10 burden burden NOUN j3860576808 9 11 at at ADP j3860576808 9 12 the the DET j3860576808 9 13 height height NOUN j3860576808 9 14 of of ADP j3860576808 9 15 infection infection NOUN j3860576808 9 16 . . PUNCT j3860576808 10 1 we we PRON j3860576808 10 2 detected detect VERB j3860576808 10 3 increased increase VERB j3860576808 10 4 levels level NOUN j3860576808 10 5 of of ADP j3860576808 10 6 neutrophils neutrophil NOUN j3860576808 10 7 at at ADP j3860576808 10 8 the the DET j3860576808 10 9 site site NOUN j3860576808 10 10 of of ADP j3860576808 10 11 infection infection NOUN j3860576808 10 12 early early ADV j3860576808 10 13 during during ADP j3860576808 10 14 infection infection NOUN j3860576808 10 15 and and CCONJ j3860576808 10 16 elevated elevated ADJ j3860576808 10 17 numbers number NOUN j3860576808 10 18 of of ADP j3860576808 10 19 macrophages macrophage NOUN j3860576808 10 20 at at ADP j3860576808 10 21 the the DET j3860576808 10 22 height height NOUN j3860576808 10 23 of of ADP j3860576808 10 24 infection infection NOUN j3860576808 10 25 . . PUNCT j3860576808 11 1 in in ADP j3860576808 11 2 response response NOUN j3860576808 11 3 to to ADP j3860576808 11 4 vitamin vitamin NOUN j3860576808 11 5 d d NOUN j3860576808 11 6 deficiency deficiency NOUN j3860576808 11 7 induced induce VERB j3860576808 11 8 by by ADP j3860576808 11 9 deletion deletion NOUN j3860576808 11 10 of of ADP j3860576808 11 11 1 1 NUM j3860576808 11 12 - - PUNCT j3860576808 11 13 ì_å± ì_å± ADJ j3860576808 11 14 hydroxylase hydroxylase NOUN j3860576808 11 15 , , PUNCT j3860576808 11 16 mice mouse NOUN j3860576808 11 17 exhibited exhibit VERB j3860576808 11 18 smaller small ADJ j3860576808 11 19 lesions lesion NOUN j3860576808 11 20 similar similar ADJ j3860576808 11 21 to to ADP j3860576808 11 22 those those PRON j3860576808 11 23 observed observe VERB j3860576808 11 24 in in ADP j3860576808 11 25 vdr vdr NOUN j3860576808 11 26 ko ko PROPN j3860576808 11 27 mice mouse NOUN j3860576808 11 28 . . PUNCT j3860576808 12 1 analysis analysis NOUN j3860576808 12 2 of of ADP j3860576808 12 3 bone bone NOUN j3860576808 12 4 marrow marrow NOUN j3860576808 12 5 derived derive VERB j3860576808 12 6 macrophages macrophage NOUN j3860576808 12 7 ( ( PUNCT j3860576808 12 8 bmdms bmdms PROPN j3860576808 12 9 ) ) PUNCT j3860576808 12 10 and and CCONJ j3860576808 12 11 bone bone NOUN j3860576808 12 12 marrow marrow NOUN j3860576808 12 13 derived derive VERB j3860576808 12 14 dendritic dendritic ADJ j3860576808 12 15 cells cell NOUN j3860576808 12 16 ( ( PUNCT j3860576808 12 17 bmdcs bmdcs PROPN j3860576808 12 18 ) ) PUNCT j3860576808 12 19 harvested harvest VERB j3860576808 12 20 from from ADP j3860576808 12 21 vdr vdr NOUN j3860576808 12 22 ko ko PROPN j3860576808 12 23 mice mouse NOUN j3860576808 12 24 indicates indicate VERB j3860576808 12 25 these these DET j3860576808 12 26 cells cell NOUN j3860576808 12 27 phagocytose phagocytose VERB j3860576808 12 28 l. l. PROPN j3860576808 12 29 major major ADJ j3860576808 12 30 parasites parasite NOUN j3860576808 12 31 at at ADP j3860576808 12 32 equal equal ADJ j3860576808 12 33 levels level NOUN j3860576808 12 34 as as ADP j3860576808 12 35 wt wt PROPN j3860576808 12 36 bmdms bmdms NOUN j3860576808 12 37 and and CCONJ j3860576808 12 38 bmdcs bmdcs PROPN j3860576808 12 39 . . PUNCT j3860576808 13 1 examination examination NOUN j3860576808 13 2 of of ADP j3860576808 13 3 parasite parasite NOUN j3860576808 13 4 clearance clearance NOUN j3860576808 13 5 mechanisms mechanism NOUN j3860576808 13 6 of of ADP j3860576808 13 7 bmdms bmdms NOUN j3860576808 13 8 and and CCONJ j3860576808 13 9 bmdcs bmdcs PROPN j3860576808 13 10 suggests suggest VERB j3860576808 13 11 that that SCONJ j3860576808 13 12 vdr vdr NOUN j3860576808 13 13 plays play VERB j3860576808 13 14 a a DET j3860576808 13 15 role role NOUN j3860576808 13 16 in in ADP j3860576808 13 17 stat1 stat1 NOUN j3860576808 13 18 inhibition inhibition NOUN j3860576808 13 19 of of ADP j3860576808 13 20 inos ino NOUN j3860576808 13 21 and and CCONJ j3860576808 13 22 il-12p40 il-12p40 PROPN j3860576808 13 23 up up NOUN j3860576808 13 24 - - PUNCT j3860576808 13 25 regulation regulation NOUN j3860576808 13 26 . . PUNCT j3860576808 14 1 overall overall ADV j3860576808 14 2 , , PUNCT j3860576808 14 3 these these DET j3860576808 14 4 studies study NOUN j3860576808 14 5 illustrate illustrate VERB j3860576808 14 6 the the DET j3860576808 14 7 importance importance NOUN j3860576808 14 8 of of ADP j3860576808 14 9 vitamin vitamin NOUN j3860576808 14 10 d d NOUN j3860576808 14 11 and and CCONJ j3860576808 14 12 vdr vdr NOUN j3860576808 14 13 in in ADP j3860576808 14 14 modulation modulation NOUN j3860576808 14 15 of of ADP j3860576808 14 16 immune immune ADJ j3860576808 14 17 responses response NOUN j3860576808 14 18 to to ADP j3860576808 14 19 l. l. PROPN j3860576808 14 20 major major ADJ j3860576808 14 21 infection infection NOUN j3860576808 14 22 . . PUNCT