id	sid	tid	token	lemma	pos
j098z89305s	1	1	novel	novel	ADJ
j098z89305s	1	2	and	and	CCONJ
j098z89305s	1	3	potentially	potentially	ADV
j098z89305s	1	4	'	'	PUNCT
j098z89305s	1	5	universal	universal	ADJ
j098z89305s	1	6	'	'	PUNCT
j098z89305s	1	7	cephalosporins	cephalosporin	NOUN
j098z89305s	1	8	were	be	AUX
j098z89305s	1	9	designed	design	VERB
j098z89305s	1	10	as	as	ADP
j098z89305s	1	11	multifunctional	multifunctional	ADJ
j098z89305s	1	12	&	&	CCONJ
j098z89305s	1	13	#	#	SYM
j098z89305s	1	14	946;-lactam	946;-lactam	NUM
j098z89305s	1	15	antibiotics	antibiotic	NOUN
j098z89305s	1	16	which	which	PRON
j098z89305s	1	17	would	would	AUX
j098z89305s	1	18	be	be	AUX
j098z89305s	1	19	useful	useful	ADJ
j098z89305s	1	20	against	against	ADP
j098z89305s	1	21	both	both	CCONJ
j098z89305s	1	22	sensitive	sensitive	ADJ
j098z89305s	1	23	and	and	CCONJ
j098z89305s	1	24	resistant	resistant	ADJ
j098z89305s	1	25	microorganisms	microorganism	NOUN
j098z89305s	1	26	.	.	PUNCT
j098z89305s	2	1	the	the	DET
j098z89305s	2	2	three	three	NUM
j098z89305s	2	3	key	key	ADJ
j098z89305s	2	4	structural	structural	ADJ
j098z89305s	2	5	variables	variable	NOUN
j098z89305s	2	6	that	that	PRON
j098z89305s	2	7	comprised	comprise	VERB
j098z89305s	2	8	this	this	DET
j098z89305s	2	9	studies	study	NOUN
j098z89305s	2	10	were	be	AUX
j098z89305s	2	11	the	the	DET
j098z89305s	2	12	r	r	NOUN
j098z89305s	2	13	group	group	NOUN
j098z89305s	2	14	,	,	PUNCT
j098z89305s	2	15	the	the	DET
j098z89305s	2	16	leaving	leave	VERB
j098z89305s	2	17	group	group	NOUN
j098z89305s	2	18	(	(	PUNCT
j098z89305s	2	19	lg	lg	PROPN
j098z89305s	2	20	)	)	PUNCT
j098z89305s	2	21	,	,	PUNCT
j098z89305s	2	22	and	and	CCONJ
j098z89305s	2	23	r§	r§	PROPN
j098z89305s	2	24	group	group	NOUN
j098z89305s	2	25	.	.	PUNCT
j098z89305s	3	1	different	different	ADJ
j098z89305s	3	2	r§	r§	PROPN
j098z89305s	3	3	and	and	CCONJ
j098z89305s	3	4	leaving	leave	VERB
j098z89305s	3	5	groups	group	NOUN
j098z89305s	3	6	were	be	AUX
j098z89305s	3	7	introduced	introduce	VERB
j098z89305s	3	8	based	base	VERB
j098z89305s	3	9	on	on	ADP
j098z89305s	3	10	their	their	PRON
j098z89305s	3	11	relative	relative	ADJ
j098z89305s	3	12	migratory	migratory	ADJ
j098z89305s	3	13	aptitude	aptitude	NOUN
j098z89305s	3	14	or	or	CCONJ
j098z89305s	3	15	on	on	ADP
j098z89305s	3	16	their	their	PRON
j098z89305s	3	17	different	different	ADJ
j098z89305s	3	18	leaving	leave	VERB
j098z89305s	3	19	abilities	ability	NOUN
j098z89305s	3	20	,	,	PUNCT
j098z89305s	3	21	respectively	respectively	ADV
j098z89305s	3	22	.	.	PUNCT
j098z89305s	4	1	it	it	PRON
j098z89305s	4	2	was	be	AUX
j098z89305s	4	3	initially	initially	ADV
j098z89305s	4	4	believed	believe	VERB
j098z89305s	4	5	that	that	SCONJ
j098z89305s	4	6	some	some	DET
j098z89305s	4	7	new	new	ADJ
j098z89305s	4	8	ìøåàå_8ìøåàå_5	ìøåàå_8ìøåàå_5	ADJ
j098z89305s	4	9	-	-	PUNCT
j098z89305s	4	10	lactamase	lactamase	NOUN
j098z89305s	4	11	inhibitors	inhibitor	NOUN
j098z89305s	4	12	could	could	AUX
j098z89305s	4	13	arise	arise	VERB
j098z89305s	4	14	from	from	ADP
j098z89305s	4	15	this	this	DET
j098z89305s	4	16	series	series	NOUN
j098z89305s	4	17	of	of	ADP
j098z89305s	4	18	cephalosporins	cephalosporin	NOUN
j098z89305s	4	19	.	.	PUNCT
j098z89305s	5	1	enzymatic	enzymatic	ADJ
j098z89305s	5	2	processing	processing	NOUN
j098z89305s	5	3	of	of	ADP
j098z89305s	5	4	the	the	DET
j098z89305s	5	5	ìøåàå_8ìøåàå_5	ìøåàå_8ìøåàå_5	ADJ
j098z89305s	5	6	-	-	PUNCT
j098z89305s	5	7	lactam	lactam	PROPN
j098z89305s	5	8	may	may	AUX
j098z89305s	5	9	release	release	VERB
j098z89305s	5	10	a	a	DET
j098z89305s	5	11	potent	potent	ADJ
j098z89305s	5	12	acylating	acylate	VERB
j098z89305s	5	13	agent	agent	NOUN
j098z89305s	5	14	called	call	VERB
j098z89305s	5	15	an	an	DET
j098z89305s	5	16	isocyanate	isocyanate	NOUN
j098z89305s	5	17	which	which	PRON
j098z89305s	5	18	can	can	AUX
j098z89305s	5	19	deactivate	deactivate	VERB
j098z89305s	5	20	ìøåàå_8ìøåàå_5	ìøåàå_8ìøåàå_5	ADJ
j098z89305s	5	21	-	-	PUNCT
j098z89305s	5	22	lactamases	lactamase	NOUN
j098z89305s	5	23	irreversibly	irreversibly	ADV
j098z89305s	5	24	.	.	PUNCT
j098z89305s	6	1	generation	generation	NOUN
j098z89305s	6	2	of	of	ADP
j098z89305s	6	3	this	this	DET
j098z89305s	6	4	isocyanate	isocyanate	NOUN
j098z89305s	6	5	can	can	AUX
j098z89305s	6	6	arise	arise	VERB
j098z89305s	6	7	from	from	ADP
j098z89305s	6	8	appropriately	appropriately	ADV
j098z89305s	6	9	substituted	substitute	VERB
j098z89305s	6	10	hydroxamates	hydroxamate	NOUN
j098z89305s	6	11	located	locate	VERB
j098z89305s	6	12	at	at	ADP
j098z89305s	6	13	the	the	DET
j098z89305s	6	14	c-3§	c-3§	ADJ
j098z89305s	6	15	position	position	NOUN
j098z89305s	6	16	of	of	ADP
j098z89305s	6	17	the	the	DET
j098z89305s	6	18	cephalosporin	cephalosporin	NOUN
j098z89305s	6	19	through	through	ADP
j098z89305s	6	20	an	an	DET
j098z89305s	6	21	intramolecular	intramolecular	ADJ
j098z89305s	6	22	lossen	lossen	NOUN
j098z89305s	6	23	rearrangement	rearrangement	NOUN
j098z89305s	6	24	after	after	ADP
j098z89305s	6	25	hydrolysis	hydrolysis	NOUN
j098z89305s	6	26	of	of	ADP
j098z89305s	6	27	the	the	DET
j098z89305s	6	28	ìøåàå_8ìøåàå_5	ìøåàå_8ìøåàå_5	ADJ
j098z89305s	6	29	-	-	PUNCT
j098z89305s	6	30	lactam	lactam	NOUN
j098z89305s	6	31	ring	ring	NOUN
j098z89305s	6	32	.	.	PUNCT
j098z89305s	7	1	,p	,p	PUNCT
j098z89305s	7	2	>	>	PUNCT
j098z89305s	7	3	several	several	ADJ
j098z89305s	7	4	new	new	ADJ
j098z89305s	7	5	c-3§-hydroxamate	c-3§-hydroxamate	ADJ
j098z89305s	7	6	substituted	substituted	ADJ
j098z89305s	7	7	cephalosporins	cephalosporin	NOUN
j098z89305s	7	8	were	be	AUX
j098z89305s	7	9	synthesized	synthesize	VERB
j098z89305s	7	10	including	include	VERB
j098z89305s	7	11	cyclic	cyclic	ADJ
j098z89305s	7	12	forms	form	NOUN
j098z89305s	7	13	32	32	NUM
j098z89305s	7	14	-	-	SYM
j098z89305s	7	15	36	36	NUM
j098z89305s	7	16	,	,	PUNCT
j098z89305s	7	17	and	and	CCONJ
j098z89305s	7	18	38	38	NUM
j098z89305s	7	19	with	with	ADP
j098z89305s	7	20	improved	improve	VERB
j098z89305s	7	21	lipophility	lipophility	NOUN
j098z89305s	7	22	and	and	CCONJ
j098z89305s	7	23	evaluated	evaluate	VERB
j098z89305s	7	24	for	for	ADP
j098z89305s	7	25	antibacterial	antibacterial	ADJ
j098z89305s	7	26	/	/	SYM
j098z89305s	7	27	anti	anti	ADJ
j098z89305s	7	28	-	-	ADJ
j098z89305s	7	29	tb	tb	ADJ
j098z89305s	7	30	activity	activity	NOUN
j098z89305s	7	31	.	.	PUNCT
j098z89305s	8	1	the	the	DET
j098z89305s	8	2	test	test	NOUN
j098z89305s	8	3	results	result	NOUN
j098z89305s	8	4	showed	show	VERB
j098z89305s	8	5	that	that	SCONJ
j098z89305s	8	6	the	the	DET
j098z89305s	8	7	ring	ring	NOUN
j098z89305s	8	8	opened	open	VERB
j098z89305s	8	9	free	free	ADJ
j098z89305s	8	10	carboxylic	carboxylic	NOUN
j098z89305s	8	11	acid	acid	NOUN
j098z89305s	8	12	hydroxamates	hydroxamate	NOUN
j098z89305s	8	13	27	27	NUM
j098z89305s	8	14	-	-	SYM
j098z89305s	8	15	31	31	NUM
j098z89305s	8	16	,	,	PUNCT
j098z89305s	8	17	and	and	CCONJ
j098z89305s	8	18	37	37	NUM
j098z89305s	8	19	are	be	AUX
j098z89305s	8	20	superior	superior	ADJ
j098z89305s	8	21	in	in	ADP
j098z89305s	8	22	activity	activity	NOUN
j098z89305s	8	23	compared	compare	VERB
j098z89305s	8	24	to	to	ADP
j098z89305s	8	25	the	the	DET
j098z89305s	8	26	corresponding	corresponding	ADJ
j098z89305s	8	27	cyclic	cyclic	ADJ
j098z89305s	8	28	hydroxamate	hydroxamate	NOUN
j098z89305s	8	29	esters	ester	NOUN
j098z89305s	8	30	32	32	NUM
j098z89305s	8	31	-	-	SYM
j098z89305s	8	32	36	36	NUM
j098z89305s	8	33	,	,	PUNCT
j098z89305s	8	34	and	and	CCONJ
j098z89305s	8	35	38	38	NUM
j098z89305s	8	36	against	against	ADP
j098z89305s	8	37	some	some	DET
j098z89305s	8	38	specific	specific	ADJ
j098z89305s	8	39	strains	strain	NOUN
j098z89305s	8	40	such	such	ADJ
j098z89305s	8	41	as	as	ADP
j098z89305s	8	42	micrococcus	micrococcus	PROPN
j098z89305s	8	43	luteus	luteus	PROPN
j098z89305s	8	44	atcc	atcc	PROPN
j098z89305s	8	45	10240	10240	NUM
j098z89305s	8	46	,	,	PUNCT
j098z89305s	8	47	bacillus	bacillus	NOUN
j098z89305s	8	48	subtilis	subtili	NOUN
j098z89305s	8	49	6633	6633	NUM
j098z89305s	8	50	and	and	CCONJ
j098z89305s	8	51	s.	s.	PROPN
j098z89305s	8	52	aureus	aureus	PROPN
j098z89305s	8	53	sg	sg	PROPN
j098z89305s	8	54	511	511	NUM
j098z89305s	8	55	.	.	PUNCT
j098z89305s	9	1	the	the	DET
j098z89305s	9	2	preliminary	preliminary	ADJ
j098z89305s	9	3	results	result	NOUN
j098z89305s	9	4	showed	show	VERB
j098z89305s	9	5	electron	electron	NOUN
j098z89305s	9	6	donating	donate	VERB
j098z89305s	9	7	groups	group	NOUN
j098z89305s	9	8	gave	give	VERB
j098z89305s	9	9	better	well	ADJ
j098z89305s	9	10	anti	anti	ADJ
j098z89305s	9	11	-	-	ADJ
j098z89305s	9	12	tb	tb	ADJ
j098z89305s	9	13	activity	activity	NOUN
j098z89305s	9	14	(	(	PUNCT
j098z89305s	9	15	33	33	NUM
j098z89305s	9	16	with	with	ADP
j098z89305s	9	17	an	an	DET
j098z89305s	9	18	mic	mic	NOUN
j098z89305s	9	19	of	of	ADP
j098z89305s	9	20	2.81	2.81	NUM
j098z89305s	9	21	ìøåàå_0ìøåàå_8	ìøåàå_0ìøåàå_8	NOUN
j098z89305s	9	22	m	m	NOUN
j098z89305s	9	23	against	against	ADP
j098z89305s	9	24	gast	gast	PROPN
j098z89305s	9	25	nrp	nrp	PROPN
j098z89305s	9	26	-	-	PUNCT
j098z89305s	9	27	tb	tb	PROPN
j098z89305s	9	28	)	)	PUNCT
j098z89305s	9	29	.	.	PUNCT
j098z89305s	10	1	this	this	DET
j098z89305s	10	2	preliminary	preliminary	ADJ
j098z89305s	10	3	study	study	NOUN
j098z89305s	10	4	provides	provide	VERB
j098z89305s	10	5	exciting	exciting	ADJ
j098z89305s	10	6	leads	lead	NOUN
j098z89305s	10	7	to	to	ADP
j098z89305s	10	8	the	the	DET
j098z89305s	10	9	possible	possible	ADJ
j098z89305s	10	10	generation	generation	NOUN
j098z89305s	10	11	of	of	ADP
j098z89305s	10	12	compounds	compound	NOUN
j098z89305s	10	13	that	that	PRON
j098z89305s	10	14	are	be	AUX
j098z89305s	10	15	selective	selective	ADJ
j098z89305s	10	16	antimicrobial	antimicrobial	ADJ
j098z89305s	10	17	agents	agent	NOUN
j098z89305s	10	18	based	base	VERB
j098z89305s	10	19	on	on	ADP
j098z89305s	10	20	variation	variation	NOUN
j098z89305s	10	21	of	of	ADP
j098z89305s	10	22	peripheral	peripheral	ADJ
j098z89305s	10	23	substituents	substituent	NOUN
j098z89305s	10	24	.	.	PUNCT
j098z89305s	11	1	to	to	PART
j098z89305s	11	2	further	far	ADV
j098z89305s	11	3	test	test	VERB
j098z89305s	11	4	this	this	DET
j098z89305s	11	5	concept	concept	NOUN
j098z89305s	11	6	,	,	PUNCT
j098z89305s	11	7	the	the	DET
j098z89305s	11	8	synthesis	synthesis	NOUN
j098z89305s	11	9	of	of	ADP
j098z89305s	11	10	an	an	DET
j098z89305s	11	11	extended	extended	ADJ
j098z89305s	11	12	library	library	NOUN
j098z89305s	11	13	will	will	AUX
j098z89305s	11	14	be	be	AUX
j098z89305s	11	15	needed.in	needed.in	NUM
j098z89305s	11	16	addition	addition	NOUN
j098z89305s	11	17	,	,	PUNCT
j098z89305s	11	18	the	the	DET
j098z89305s	11	19	direct	direct	ADJ
j098z89305s	11	20	amine	amine	NOUN
j098z89305s	11	21	-	-	PUNCT
j098z89305s	11	22	linked	link	VERB
j098z89305s	11	23	quinolone	quinolone	PROPN
j098z89305s	11	24	-	-	PUNCT
j098z89305s	11	25	cephem	cephem	PROPN
j098z89305s	11	26	74	74	NUM
j098z89305s	11	27	and	and	CCONJ
j098z89305s	11	28	carbamate	carbamate	NOUN
j098z89305s	11	29	-	-	PUNCT
j098z89305s	11	30	linked	link	VERB
j098z89305s	11	31	quinolone	quinolone	PROPN
j098z89305s	11	32	-	-	PUNCT
j098z89305s	11	33	cephem	cephem	PROPN
j098z89305s	11	34	77	77	NUM
j098z89305s	11	35	,	,	PUNCT
j098z89305s	11	36	and	and	CCONJ
j098z89305s	11	37	their	their	PRON
j098z89305s	11	38	corresponding	correspond	VERB
j098z89305s	11	39	esters	ester	NOUN
j098z89305s	11	40	73	73	NUM
j098z89305s	11	41	and	and	CCONJ
j098z89305s	11	42	76	76	NUM
j098z89305s	11	43	were	be	AUX
j098z89305s	11	44	synthesized	synthesize	VERB
j098z89305s	11	45	and	and	CCONJ
j098z89305s	11	46	evaluated	evaluate	VERB
j098z89305s	11	47	for	for	ADP
j098z89305s	11	48	anti	anti	ADJ
j098z89305s	11	49	-	-	ADJ
j098z89305s	11	50	bacterial	bacterial	ADJ
j098z89305s	11	51	activity	activity	NOUN
j098z89305s	11	52	.	.	PUNCT
j098z89305s	12	1	all	all	DET
j098z89305s	12	2	conjugates	conjugate	NOUN
j098z89305s	12	3	and	and	CCONJ
j098z89305s	12	4	their	their	PRON
j098z89305s	12	5	esters	ester	NOUN
j098z89305s	12	6	showed	show	VERB
j098z89305s	12	7	good	good	ADJ
j098z89305s	12	8	activity	activity	NOUN
j098z89305s	12	9	against	against	ADP
j098z89305s	12	10	various	various	ADJ
j098z89305s	12	11	strains	strain	NOUN
j098z89305s	12	12	of	of	ADP
j098z89305s	12	13	bacteria	bacteria	NOUN
j098z89305s	12	14	.	.	PUNCT
j098z89305s	13	1	conjugate	conjugate	NOUN
j098z89305s	13	2	74	74	NUM
j098z89305s	13	3	,	,	PUNCT
j098z89305s	13	4	the	the	DET
j098z89305s	13	5	amine	amine	NOUN
j098z89305s	13	6	-	-	PUNCT
j098z89305s	13	7	linked	link	VERB
j098z89305s	13	8	quinolone	quinolone	PROPN
j098z89305s	13	9	-	-	PUNCT
j098z89305s	13	10	cephalosporin	cephalosporin	NOUN
j098z89305s	13	11	,	,	PUNCT
j098z89305s	13	12	was	be	AUX
j098z89305s	13	13	more	more	ADV
j098z89305s	13	14	active	active	ADJ
j098z89305s	13	15	against	against	ADP
j098z89305s	13	16	some	some	DET
j098z89305s	13	17	gram	gram	ADJ
j098z89305s	13	18	-	-	PUNCT
j098z89305s	13	19	negative	negative	ADJ
j098z89305s	13	20	bacteria	bacteria	NOUN
j098z89305s	13	21	,	,	PUNCT
j098z89305s	13	22	while	while	SCONJ
j098z89305s	13	23	the	the	DET
j098z89305s	13	24	carbamate	carbamate	NOUN
j098z89305s	13	25	-	-	PUNCT
j098z89305s	13	26	linked	link	VERB
j098z89305s	13	27	conjugate	conjugate	NOUN
j098z89305s	13	28	77	77	NUM
j098z89305s	13	29	had	have	VERB
j098z89305s	13	30	superior	superior	ADJ
j098z89305s	13	31	antimycobacterial	antimycobacterial	ADJ
j098z89305s	13	32	/	/	SYM
j098z89305s	13	33	anti	anti	ADJ
j098z89305s	13	34	-	-	ADJ
j098z89305s	13	35	tb	tb	ADJ
j098z89305s	13	36	activity	activity	NOUN
j098z89305s	13	37	with	with	ADP
j098z89305s	13	38	an	an	DET
j098z89305s	13	39	mic	mic	NOUN
j098z89305s	13	40	of	of	ADP
j098z89305s	13	41	0.94	0.94	NUM
j098z89305s	13	42	ìøåàå_0ìøåàå_8	ìøåàå_0ìøåàå_8	NOUN
j098z89305s	13	43	m.	m.	NOUN