id	sid	tid	token	lemma	pos
ht24wh26f8f	1	1	the	the	DET
ht24wh26f8f	1	2	epothilones	epothilone	NOUN
ht24wh26f8f	1	3	are	be	AUX
ht24wh26f8f	1	4	a	a	DET
ht24wh26f8f	1	5	family	family	NOUN
ht24wh26f8f	1	6	of	of	ADP
ht24wh26f8f	1	7	natural	natural	ADJ
ht24wh26f8f	1	8	products	product	NOUN
ht24wh26f8f	1	9	isolated	isolate	VERB
ht24wh26f8f	1	10	as	as	ADP
ht24wh26f8f	1	11	secondary	secondary	ADJ
ht24wh26f8f	1	12	metabolites	metabolite	NOUN
ht24wh26f8f	1	13	from	from	ADP
ht24wh26f8f	1	14	the	the	DET
ht24wh26f8f	1	15	soil	soil	NOUN
ht24wh26f8f	1	16	bacteria	bacteria	NOUN
ht24wh26f8f	1	17	,	,	PUNCT
ht24wh26f8f	1	18	sorangium	sorangium	NOUN
ht24wh26f8f	1	19	cellulosum	cellulosum	NOUN
ht24wh26f8f	1	20	.	.	PUNCT
ht24wh26f8f	2	1	it	it	PRON
ht24wh26f8f	2	2	was	be	AUX
ht24wh26f8f	2	3	discovered	discover	VERB
ht24wh26f8f	2	4	that	that	SCONJ
ht24wh26f8f	2	5	they	they	PRON
ht24wh26f8f	2	6	inhibit	inhibit	VERB
ht24wh26f8f	2	7	tumor	tumor	NOUN
ht24wh26f8f	2	8	cell	cell	NOUN
ht24wh26f8f	2	9	proliferation	proliferation	NOUN
ht24wh26f8f	2	10	via	via	ADP
ht24wh26f8f	2	11	microtubule	microtubule	NOUN
ht24wh26f8f	2	12	stabilization	stabilization	NOUN
ht24wh26f8f	2	13	,	,	PUNCT
ht24wh26f8f	2	14	exhibiting	exhibit	VERB
ht24wh26f8f	2	15	the	the	DET
ht24wh26f8f	2	16	same	same	ADJ
ht24wh26f8f	2	17	mode	mode	NOUN
ht24wh26f8f	2	18	of	of	ADP
ht24wh26f8f	2	19	action	action	NOUN
ht24wh26f8f	2	20	as	as	ADP
ht24wh26f8f	2	21	the	the	DET
ht24wh26f8f	2	22	famous	famous	ADJ
ht24wh26f8f	2	23	therapeutic	therapeutic	ADJ
ht24wh26f8f	2	24	paclitaxel	paclitaxel	NOUN
ht24wh26f8f	2	25	,	,	PUNCT
ht24wh26f8f	2	26	or	or	CCONJ
ht24wh26f8f	2	27	taxol	taxol	NOUN
ht24wh26f8f	2	28	,	,	PUNCT
ht24wh26f8f	2	29	but	but	CCONJ
ht24wh26f8f	2	30	with	with	ADP
ht24wh26f8f	2	31	improved	improved	ADJ
ht24wh26f8f	2	32	properties	property	NOUN
ht24wh26f8f	2	33	.	.	PUNCT
ht24wh26f8f	3	1	this	this	DET
ht24wh26f8f	3	2	dissertation	dissertation	NOUN
ht24wh26f8f	3	3	describes	describe	VERB
ht24wh26f8f	3	4	a	a	DET
ht24wh26f8f	3	5	precursor	precursor	NOUN
ht24wh26f8f	3	6	directed	direct	VERB
ht24wh26f8f	3	7	biosynthesis	biosynthesis	NOUN
ht24wh26f8f	3	8	approach	approach	NOUN
ht24wh26f8f	3	9	to	to	ADP
ht24wh26f8f	3	10	epothilones	epothilone	NOUN
ht24wh26f8f	3	11	using	use	VERB
ht24wh26f8f	3	12	the	the	DET
ht24wh26f8f	3	13	enzyme	enzyme	NOUN
ht24wh26f8f	3	14	machinery	machinery	NOUN
ht24wh26f8f	3	15	that	that	PRON
ht24wh26f8f	3	16	produces	produce	VERB
ht24wh26f8f	3	17	these	these	DET
ht24wh26f8f	3	18	molecules	molecule	NOUN
ht24wh26f8f	3	19	in	in	ADP
ht24wh26f8f	3	20	nature	nature	NOUN
ht24wh26f8f	3	21	.	.	PUNCT
ht24wh26f8f	4	1	three	three	NUM
ht24wh26f8f	4	2	precursors	precursor	NOUN
ht24wh26f8f	4	3	to	to	ADP
ht24wh26f8f	4	4	epothilones	epothilone	NOUN
ht24wh26f8f	4	5	were	be	AUX
ht24wh26f8f	4	6	synthesized	synthesize	VERB
ht24wh26f8f	4	7	and	and	CCONJ
ht24wh26f8f	4	8	participated	participate	VERB
ht24wh26f8f	4	9	in	in	ADP
ht24wh26f8f	4	10	precursor	precursor	NOUN
ht24wh26f8f	4	11	directed	direct	VERB
ht24wh26f8f	4	12	biosynthesis	biosynthesis	NOUN
ht24wh26f8f	4	13	using	use	VERB
ht24wh26f8f	4	14	individually	individually	ADV
ht24wh26f8f	4	15	expressed	express	VERB
ht24wh26f8f	4	16	modules	module	NOUN
ht24wh26f8f	4	17	of	of	ADP
ht24wh26f8f	4	18	the	the	DET
ht24wh26f8f	4	19	epothilone	epothilone	NOUN
ht24wh26f8f	4	20	-	-	PUNCT
ht24wh26f8f	4	21	producing	produce	VERB
ht24wh26f8f	4	22	enzyme	enzyme	NOUN
ht24wh26f8f	4	23	system	system	NOUN
ht24wh26f8f	4	24	.	.	PUNCT
ht24wh26f8f	5	1	the	the	DET
ht24wh26f8f	5	2	completion	completion	NOUN
ht24wh26f8f	5	3	of	of	ADP
ht24wh26f8f	5	4	the	the	DET
ht24wh26f8f	5	5	synthesis	synthesis	NOUN
ht24wh26f8f	5	6	of	of	ADP
ht24wh26f8f	5	7	the	the	DET
ht24wh26f8f	5	8	naturally	naturally	ADV
ht24wh26f8f	5	9	occurring	occur	VERB
ht24wh26f8f	5	10	epothilone	epothilone	NOUN
ht24wh26f8f	5	11	d	d	PROPN
ht24wh26f8f	5	12	was	be	AUX
ht24wh26f8f	5	13	accomplished	accomplish	VERB
ht24wh26f8f	5	14	by	by	ADP
ht24wh26f8f	5	15	the	the	DET
ht24wh26f8f	5	16	appropriate	appropriate	ADJ
ht24wh26f8f	5	17	enzymes	enzyme	NOUN
ht24wh26f8f	5	18	expressed	express	VERB
ht24wh26f8f	5	19	in	in	ADP
ht24wh26f8f	5	20	host	host	NOUN
ht24wh26f8f	5	21	bacteria	bacteria	NOUN
ht24wh26f8f	5	22	.	.	PUNCT
ht24wh26f8f	6	1	two	two	NUM
ht24wh26f8f	6	2	analogues	analogue	NOUN
ht24wh26f8f	6	3	containing	contain	VERB
ht24wh26f8f	6	4	a	a	DET
ht24wh26f8f	6	5	c14	c14	NOUN
ht24wh26f8f	6	6	-	-	PUNCT
ht24wh26f8f	6	7	me	i	PRON
ht24wh26f8f	6	8	group	group	NOUN
ht24wh26f8f	6	9	were	be	AUX
ht24wh26f8f	6	10	also	also	ADV
ht24wh26f8f	6	11	introduced	introduce	VERB
ht24wh26f8f	6	12	to	to	ADP
ht24wh26f8f	6	13	the	the	DET
ht24wh26f8f	6	14	recombinant	recombinant	ADJ
ht24wh26f8f	6	15	enzyme	enzyme	NOUN
ht24wh26f8f	6	16	system	system	NOUN
ht24wh26f8f	6	17	.	.	PUNCT
ht24wh26f8f	7	1	it	it	PRON
ht24wh26f8f	7	2	is	be	AUX
ht24wh26f8f	7	3	known	know	VERB
ht24wh26f8f	7	4	that	that	SCONJ
ht24wh26f8f	7	5	a	a	DET
ht24wh26f8f	7	6	c14	c14	NOUN
ht24wh26f8f	7	7	-	-	PUNCT
ht24wh26f8f	7	8	me	i	PRON
ht24wh26f8f	7	9	group	group	NOUN
ht24wh26f8f	7	10	can	can	AUX
ht24wh26f8f	7	11	bias	bias	VERB
ht24wh26f8f	7	12	the	the	DET
ht24wh26f8f	7	13	conformation	conformation	NOUN
ht24wh26f8f	7	14	of	of	ADP
ht24wh26f8f	7	15	the	the	DET
ht24wh26f8f	7	16	otherwise	otherwise	ADV
ht24wh26f8f	7	17	flexible	flexible	ADJ
ht24wh26f8f	7	18	polyketide	polyketide	NOUN
ht24wh26f8f	7	19	in	in	ADP
ht24wh26f8f	7	20	an	an	DET
ht24wh26f8f	7	21	active	active	ADJ
ht24wh26f8f	7	22	or	or	CCONJ
ht24wh26f8f	7	23	inactive	inactive	ADJ
ht24wh26f8f	7	24	form	form	NOUN
ht24wh26f8f	7	25	based	base	VERB
ht24wh26f8f	7	26	on	on	ADP
ht24wh26f8f	7	27	the	the	DET
ht24wh26f8f	7	28	stereochemistry	stereochemistry	NOUN
ht24wh26f8f	7	29	at	at	ADP
ht24wh26f8f	7	30	this	this	DET
ht24wh26f8f	7	31	center	center	NOUN
ht24wh26f8f	7	32	.	.	PUNCT
ht24wh26f8f	8	1	however	however	ADV
ht24wh26f8f	8	2	,	,	PUNCT
ht24wh26f8f	8	3	when	when	SCONJ
ht24wh26f8f	8	4	intermediates	intermediate	NOUN
ht24wh26f8f	8	5	including	include	VERB
ht24wh26f8f	8	6	the	the	DET
ht24wh26f8f	8	7	c14	c14	NOUN
ht24wh26f8f	8	8	-	-	PUNCT
ht24wh26f8f	8	9	me	i	PRON
ht24wh26f8f	8	10	group	group	NOUN
ht24wh26f8f	8	11	were	be	AUX
ht24wh26f8f	8	12	subjected	subject	VERB
ht24wh26f8f	8	13	to	to	ADP
ht24wh26f8f	8	14	epothilone	epothilone	NOUN
ht24wh26f8f	8	15	producing	produce	VERB
ht24wh26f8f	8	16	enzymes	enzyme	NOUN
ht24wh26f8f	8	17	,	,	PUNCT
ht24wh26f8f	8	18	the	the	DET
ht24wh26f8f	8	19	desired	desire	VERB
ht24wh26f8f	8	20	products	product	NOUN
ht24wh26f8f	8	21	were	be	AUX
ht24wh26f8f	8	22	not	not	PART
ht24wh26f8f	8	23	formed	form	VERB
ht24wh26f8f	8	24	in	in	ADP
ht24wh26f8f	8	25	quantities	quantity	NOUN
ht24wh26f8f	8	26	comparable	comparable	ADJ
ht24wh26f8f	8	27	to	to	ADP
ht24wh26f8f	8	28	the	the	DET
ht24wh26f8f	8	29	natural	natural	ADJ
ht24wh26f8f	8	30	substrate	substrate	NOUN
ht24wh26f8f	8	31	.	.	PUNCT
ht24wh26f8f	9	1	studies	study	NOUN
ht24wh26f8f	9	2	with	with	ADP
ht24wh26f8f	9	3	the	the	DET
ht24wh26f8f	9	4	isolated	isolated	ADJ
ht24wh26f8f	9	5	thioesterase	thioesterase	NOUN
ht24wh26f8f	9	6	domain	domain	NOUN
ht24wh26f8f	9	7	on	on	ADP
ht24wh26f8f	9	8	synthetic	synthetic	ADJ
ht24wh26f8f	9	9	standards	standard	NOUN
ht24wh26f8f	9	10	suggest	suggest	VERB
ht24wh26f8f	9	11	this	this	DET
ht24wh26f8f	9	12	final	final	ADJ
ht24wh26f8f	9	13	domain	domain	NOUN
ht24wh26f8f	9	14	's	's	PART
ht24wh26f8f	9	15	activity	activity	NOUN
ht24wh26f8f	9	16	is	be	AUX
ht24wh26f8f	9	17	diminished	diminish	VERB
ht24wh26f8f	9	18	when	when	SCONJ
ht24wh26f8f	9	19	a	a	DET
ht24wh26f8f	9	20	methyl	methyl	NOUN
ht24wh26f8f	9	21	substituent	substituent	NOUN
ht24wh26f8f	9	22	is	be	AUX
ht24wh26f8f	9	23	present	present	ADJ
ht24wh26f8f	9	24	at	at	ADP
ht24wh26f8f	9	25	c14	c14	NOUN
ht24wh26f8f	9	26	,	,	PUNCT
ht24wh26f8f	9	27	a	a	DET
ht24wh26f8f	9	28	plausible	plausible	ADJ
ht24wh26f8f	9	29	reason	reason	NOUN
ht24wh26f8f	9	30	for	for	ADP
ht24wh26f8f	9	31	lack	lack	NOUN
ht24wh26f8f	9	32	of	of	ADP
ht24wh26f8f	9	33	formation	formation	NOUN
ht24wh26f8f	9	34	of	of	ADP
ht24wh26f8f	9	35	these	these	DET
ht24wh26f8f	9	36	analogues	analogue	NOUN
ht24wh26f8f	9	37	.	.	PUNCT
ht24wh26f8f	10	1	precursor	precursor	PROPN
ht24wh26f8f	10	2	directed	direct	VERB
ht24wh26f8f	10	3	biosynthesis	biosynthesis	NOUN
ht24wh26f8f	10	4	is	be	AUX
ht24wh26f8f	10	5	aided	aid	VERB
ht24wh26f8f	10	6	by	by	ADP
ht24wh26f8f	10	7	the	the	DET
ht24wh26f8f	10	8	availability	availability	NOUN
ht24wh26f8f	10	9	of	of	ADP
ht24wh26f8f	10	10	such	such	ADJ
ht24wh26f8f	10	11	synthetic	synthetic	ADJ
ht24wh26f8f	10	12	standards	standard	NOUN
ht24wh26f8f	10	13	.	.	PUNCT
ht24wh26f8f	11	1	this	this	DET
ht24wh26f8f	11	2	thesis	thesis	NOUN
ht24wh26f8f	11	3	includes	include	VERB
ht24wh26f8f	11	4	the	the	DET
ht24wh26f8f	11	5	total	total	ADJ
ht24wh26f8f	11	6	synthesis	synthesis	NOUN
ht24wh26f8f	11	7	of	of	ADP
ht24wh26f8f	11	8	one	one	NUM
ht24wh26f8f	11	9	analogue	analogue	NOUN
ht24wh26f8f	11	10	,	,	PUNCT
ht24wh26f8f	11	11	c14	c14	NOUN
ht24wh26f8f	11	12	-	-	PUNCT
ht24wh26f8f	11	13	methyl	methyl	NOUN
ht24wh26f8f	11	14	,	,	PUNCT
ht24wh26f8f	11	15	c16	c16	NOUN
ht24wh26f8f	11	16	-	-	PUNCT
ht24wh26f8f	11	17	desmethyl	desmethyl	PROPN
ht24wh26f8f	11	18	-	-	PUNCT
ht24wh26f8f	11	19	epothilone	epothilone	PROPN
ht24wh26f8f	11	20	d	d	PROPN
ht24wh26f8f	11	21	,	,	PUNCT
ht24wh26f8f	11	22	whose	whose	DET
ht24wh26f8f	11	23	semi	semi	NOUN
ht24wh26f8f	11	24	biosynthesis	biosynthesis	NOUN
ht24wh26f8f	11	25	was	be	AUX
ht24wh26f8f	11	26	attempted	attempt	VERB
ht24wh26f8f	11	27	.	.	PUNCT